BookGad Frankel, Eliora Z. Ron, editors.
Summary: Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
Contents:
Shigella and enteroinvasive Escherichia coli / Ilia Belotserkovsky and Philippe J. Sansonetti
Enteroaggregative Escherichia coli / Claire Jenkins
TheType III secretion system of pathogenic Escherichia coli / Sabrina L. Slater, Agnes m. Sagfors, Dominic J. Pollard, David Ruano-Gallego and Gad Frankel
Modulation of host cell processes by T3SS effectors / Avinash R. Shenoy, R. Christopher D. Funiss, Philippa J. Goddard and Abigail Clements
The 2011 German Enterohemorrhagic Escherichia coli O104:H4 outbreak - the danger is still out there / Stefanie Kampmeier, Michael Berger, Alexander Mellmann, Helge Karch, and Petya Berger
Extraintestinal pathogenic Escherichia coli / Dvora Biran and Eliora Z. Ron
Pandemic bacteremic Escherichia Coli strains: evoluation and emergence of drug-resistant pathogens / Yael Yair and Uri Gophna
Current trends in antimicrobial resistance of Escherichia coli / Yossi Paitan
Vaccines against Escherichia coli / Barbara Nesta and Mariagrazia Pizza.
Location
Version
Call Number
Items