Bookedited by Sinem Esra Sahingur.
Summary: This book equips dental care providers with a thorough understanding of the emerging therapies that promise to revolutionize the clinical management of periodontal diseases. Existing therapies targeted to the oral microbiome alone often fail to provide favorable clinical outcomes. Local inflammation and tissue destruction may persist and periodontal tissue regeneration is not predictably achieved. In recognition of these shortcomings, current research efforts are focused on understanding the biological interactions between the host and the resident microbiome and identifying key molecules and molecular pathways that can be used for more targeted, individualized therapies that will restrain oral inflammation and restore periodontal tissue homeostasis. This book introduces novel concepts and molecules that are currently being tested in preclinical and clinical models. Readers will find detailed information from leading experts on specific therapeutic strategies targeting the host immune and inflammatory system, the oral microbiome, and regeneration.
Contents:
Intro
Contents
Part I: Periodontal Therapies Targeting Host Immune and Inflammatory System
1: Evolving Paradigms in the Pathogenesis and Management of Periodontitis
1.1 Introduction
1.2 The Pathophysiological Stages of Periodontal Lesion
1.3 Evolving Paradigms in the Pathogenesis of Periodontitis
1.4 Evolving Paradigms in Periodontitis Patient Management
References
2: Complement C3 as a Target of Host Modulation in Periodontitis
2.1 Introduction
2.2 Complement and Regulation of the Host Response
2.3 Complement Involvement in Periodontal Disease 2.4 Periodontal Bacteria and Inflammation
2.5 Translational Studies for Safety and Efficacy of C3 Inhibition in Periodontitis
2.6 Concluding Remarks and Outlook
References
3: Resolvins in Periodontal Tissue Homeostasis (Emerging Therapies)
3.1 Introduction
3.2 Inflammatory Pathways
3.3 Natural, Endogenous Resolution of Inflammation (Lipoxins)
3.4 Resolvins
3.5 Resolution of Inflammation as a Therapeutic Modality
3.6 Inflammation, Periodontitis, and Systemic Inflammatory Diseases
3.7 Periodontal Regeneration 3.8 Dietary Supplementation of Omega-3 Polyunsaturated Fatty Acids in Periodontal Disease
3.9 Conclusion
References
4: Salicylic Acid Polymers in Periodontal Tissue Healing
4.1 Formulations: Fibers, Gels, and Microparticles
4.2 Localized SA Release Influences Inflammation with Bone
4.3 Bone Regeneration with SAPAE
4.4 SAPAE for Treatment of Osseous Defects in Diabetic Conditions
4.5 Potential Treatment of Peri-implantitis (Peri-implantitis) with SAPAE
4.6 Diabetes and Peri-implantitis 4.7 Potential Role of SAPAE in Peri-implantitis in Normal or Diabetic Situations
References
5: Targeting MAPK/MKP Signaling as a Therapeutic Axis in Periodontal Disease
5.1 Overview of Osteoimmunology During Periodontal Disease Progression
5.2 General Aspects of the MAPK/MKP Signaling Axis
5.3 MAPK/MKP Signaling in Osteoclastogenesis
5.4 Therapeutic Targeting of p38/MK2 Signaling in Periodontal Disease
5.5 Therapeutic Targeting of MKP-1 Signaling in Periodontal Disease
5.6 Conclusion
References
6: The IL-17/Th17 Axis as a Therapeutic Target in Periodontitis 6.1 Introduction
6.2 Interleukin-17: A Cytokine with Critical Functions in Mucosal Immunity and Inflammation
6.3 Th17 Cell Differentiation
6.4 The Th17/IL-17 Axis in Periodontitis
6.5 How Do IL-17A and Th17 Cells Mediate Periodontitis Immunopathology?
6.6 Therapeutic Targeting of the Th17/IL-17 Axis
6.7 Therapeutic Targeting of the Th17 Axis in Rare-Monogenic Forms of Periodontitis
6.8 Conclusion
References
7: Epigenetic and Gene Modification Precision Medicine Approaches for the "Chronic Destructive Perio-Diseases": Periodontitis and Peri-implantitis
7.1 Introduction