Books

Library construction for mutation identification by whole-genome sequencing / Harold E. Smith -- Fundamentals of comparative genome analysis in caenorhabditis nematodes / Eric S. Haag and Cristel G. Thomas -- Genetic methods for cellular manipulations in C. elegans / Menachem Katz -- Fusion PCR method for expressing genetic tools in C. elegans / Yifat Eliezer and Alon Zaslaver -- Transposon-assisted genetic engineering with Mos1- mediated single-copy insertion (MosSCI) / Christian Frøkjær-Jensen -- Creating genome modifications in C. elegans using the CRISPR/Cas9 system / John A. Calarco and Ari E. Friedland -- Observing and quantifying fluorescent reporters / Michael Hendricks -- Microbial rhodopsin optogenetic tools : application for analyses of synaptic transmission and of neuronal network activity in behavior / Caspar Glock, Jatin Nagpal, and Alexander Gottschalk -- Simultaneous optogenetic stimulation of individual pharyngeal neurons and monitoring of feeding behavior in intact C. elegans / Nicholas F. Trojanowski and Christopher Fang-Yen -- High-pressure freeze and freeze substitution electron microscopy in C. elegans / Laura Manning and Janet Richmond -- Electron tomography methods for C. elegans / David H. Hall and William J. Rice -- Microfluidic devices for behavioral analysis, microscopy, and neuronal imaging in Caenorhabditis elegans / Ross C. Lagoy and Dirk R. Albrecht -- Tracking single C. elegans using a USB microscope on a motorized stage / Eviatar I. Yemini and André E. X. Brown -- Imaging system for C. elegans behavior / Matthew A. Churgin and Christopher Fang-Yen -- Method for obtaining large populations of synchronized Caenorhabditis elegans dauer larvae / Maria C. Ow and Sarah E. Hall -- Sampling and isolation of C. elegans from the natural habitat / Nausicaa Poullet and Christian Braendle -- Primer on prototyping / Dylan Lynch and David Biron -- Primer on quantitative modeling / Iulia Neagu and Erel Levine.

This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors' role in the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) - one of the first steps in responding to foreign and potentially dangerous structures in the human body. The respective chapters chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the latest research, they may also provide novel points of departure for future drug development.

"There are few disciplines as exciting and forward-looking as medicine. Unfortunately, however, many modern practitioners have lost sight of the origins of their discipline. A Cabinet of Ancient Medical Curiosities aspires to cure this lapse by taking readers back to the early days of Western medicine in ancient Greece and Rome. Quoting the actual words of ancient authors, often from texts which have never before been translated into English, J. C. McKeown offers a fascinating glimpse at the origins of surgery, gynecology, pediatrics, pharmacology, diet and nutrition, and many other fields of medicine. This book features hundreds of passages from Greek and Roman authors, with gentle guidance from McKeown, giving a vividly direct picture of the ancient medical world, a world in which, for example, a surgeon had to be strong-minded enough to ignore the screams of his patient, diseases were assumed to be sent by the gods, medicine and magic were often indistinguishable, and no qualifications were required before setting oneself up as a doctor." -- Provided by publisher.

This book outlines the interaction of cadmium with the proteome and signalling molecules of mammalian cells. Chapters from expert contributors cover topics such as cadmium chemical biology, membrane receptors and transporters for cadmium and cadmium complexes, and targets of cadmium toxicity. Students and researchers working in bioinorganic chemistry will find this book an important account.

This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium -New Aspects in Human Disease, Rice Contamination, and Cytotoxicity- is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.

Section 1: Radiation effects and safety. Radiation bioeffects, risks, and radiation protection in medical imaging in children -- Media. Magnetic resonance safety -- Complications of contrast -- Section 2: Head and neck. Part 1: Orbit. Embryology, anatomy, normal findings, and imaging techniques -- Prenatal, congenital, and neonatal abnormalities -- Orbit infection and inflammation -- Orbital neoplasia -- Part 2: Nose and sinuses. Nose and sinonasal cavities -- Part 3: Ear and temporal bone. Embryology, anatomy, normal findings, and imaging techniques -- Congenital and neonatal abnormalities -- Infection and inflammation -- Neoplasia -- Part 4: Neck. Embryology, anatomy, normal findings, and imaging techniques -- Prenatal, congenital, and neonatal abnormalities -- Infection and inflammation -- Neoplasia -- Part 5: Thyroid and parathyroid. Thyroid and parathyroid -- Section 3: Neuroradiology. Part 1: Cranium and face. Embryology, anatomy, normal findings, and imaging techniques -- Prenatal imaging -- Craniosynostosis, selected craniofacial syndromes, and other abnormalities of the skull -- Neoplasms, neoplasm-like lesions, and infections of the skull -- Part 2: Mandible. The mandible -- Part 3: Skull and facial trauma. Traumatic lesions of the skull and face -- Part 4: Brain. Embryology and brain development -- Magnetic resonance spectroscopy and positron emission tomography -- Diffusion-weighted magnetic resonance imaging: principles and implementation in clinical and research settings -- Functional magnetic resonance imaging -- Perfusion imaging and magnetoencephalography -- Prenatal imaging -- Neonatal brain injury -- Congenital brain malformations -- Hydrocephalus -- Inherited metabolic and neurodegenerative disorders -- Infection and inflammation -- Pediatric brain neoplasms -- Cerebrovascular disorders -- Stroke -- Neuroimaging in pediatric epilepsy -- Trauma -- Part 5: Vertebral column and spinal cord. Embryology, anatomy, and normal findings -- Spinal cord imaging techniques -- Prenatal imaging -- Congenital abnormalities of the spine -- Infections of the spine and spinal cord -- Spinal tumor and tumorlike conditions -- Vascular lesions -- Trauma -- Section 4: Respiratory system. Part 1. Overview. Embryology, anatomy and neonatal lung pathophysiology -- Imaging techniques -- Prenatal imaging and intervention -- Part 2: Airway. Upper airway disease -- Lower large airway disease -- Part 3: Lungs. Congenital lung anomalies -- Pulmonary infection -- Neoplasia -- Diffuse lung disease -- Pulmonary manifestations of systemic disease -- Part 4: Mediastinum. The mediastinum -- Part 5: Chest wall, pleura, and diaphragm. The chest wall -- The pleura -- The diaphragm -- Section 5: Heart and great vessels. Part 1: Overview. Introductory embryology -- Cardiovascular anatomy and segmental approach to imaging of congenital heart disease -- Part 2: Imaging techniques. Pediatric echocardiography -- Chest radiography in pediatric cardiovascular disease -- Pediatric cardiothoracic computed tomographic angiography -- Magnetic resonance imaging for congenital heart disease -- Pediatric cardiac catheterization and electrophysiology -- Surgical considerations for congenital heart disease -- Prenatal imaging and therapy of congenital heart disease -- Part 3: Congenital and cardiovascular abnormalities. Abnormal pulmonary and systemic venous connections -- Systemic to pulmonary arterial shunts -- Left heart lesions -- Right heart lesions -- Conotruncal anomalies -- Congenital anomalies of the thoracic great arteries -- Coronary artery disease in children -- Syndromes and chromosomal anomalies -- Part 4: Acquired cardiovascular abnormalities. Myocardial, endocardial and pericardial diseases -- Cardiac and pericardial tumors -- Cardiovascular involvement by systemic diseases -- Acquired diseases of the thoracic great vessels -- Section 6: Gastrointestinal system. Part 1: Overview. Embryology, anatomy, and normal findings -- Imaging techniques -- Prenatal gastrointestinal and hepatobiliary imaging -- The abdominal wall and peritoneal cavity -- Part 2: Hepatobiliary system. Congenital hepatobiliary abnormalities -- Acquired biliary tract disease -- Parenchymal liver disease -- Infectious causes of liver disease -- Neoplasia -- Vascular abnormalities of the liver -- Liver transplantation in children -- Part 3: Spleen. The spleen -- Part 4: Pancreas. The pancreas -- Part 5: Esophagus. Congenital and neonatal abnormalities -- Disorders of swallowing -- Acquired esophageal disorders -- Part 6: Stomach. Congenital and neonatal abnormalities -- Hypertrophic pyloric stenosis -- Acquired disorders -- Part 7: Duodenum and small intestine. Congenital and neonatal abnormalities -- Acquired abnormalities -- Acquired lesions of the small intestines -- Part 8: Colon. Congenital and neonatal abnormalities -- Inflammatory and infectious diseases -- Intussusception -- Tumors and tumorlike conditions -- Abdominal trauma -- Section 7: Genitourinary system. Part 1: Overview -- Embryology, anatomy, and variants of the genitourinary tract -- Imaging techniques -- Prenatal imaging and intervention -- Part 2: Prenatal imaging and intervention. Congenital and neonatal abnormalities -- Acquired abnormalities (Stone disease and infection) -- Renal neoplasms -- Vascular conditions -- Renal failure and transplantation -- Part 3: Lower urinary tract. The ureter -- Vesicoureteral reflux -- Bladder and urethra -- Part 4: Adrenal and retroperitoneum. Congenital and neonatal conditions -- Acquired conditions -- Part 5: Trauma. Genitourinary trauma -- Part 6: Reproductive organs. Disorders of sex differentiation -- Abnormalities of the male genital tract -- Abnormalities of the female genital tract -- Amenorrhea and abnormalities of puberty -- Section 8: Musculoskeletal system. Part 1: Overview. Embryology, anatomy, and normal findings -- Imaging techniques -- Prenatal musculoskeletal imaging -- Part 2: Congenital malformations. Congenital anomalies of bone -- Skeletal dysplasias and selected chromosomal disorders -- Part 3: Disorders in alignment. Alignment disorders -- Scoliosis -- Developmental dysplasia of the hip -- Part 4: Arthritides and other inflammatory disorders. Arthritis and differential inflammatory joint disorders -- Part 5: Infections. Musculoskeletal infections -- Part 6: Tumors and tumor-like conditions. Soft tissue and bone tumors -- Part 7: Metabolic and endocrine disorders. Metabolic bone disease -- Endocrine disorders -- Part 8: Systemic disease. Skeletal manifestations of systemic disease -- Part 9: Trauma. Skeletal trauma -- Child abuse -- Sports medicine.

This collection contains hundreds of beautiful rarely-seen-before figures produced throughout the nineteenth century and the beginning of the twentieth century by famed father-of-modern-neuroscience Santiago Ramón y Cajal (1852-1934) and his contemporaries. Cajal was captivated by the beautiful shapes of the cells of the nervous system. He and his fellow scientists saw neurons as trees and glial cells as bushes. Given their high density and arrangement, neurons and glial resembled a thick forest, a seemingly impenetrable terrain of interacting cells mediating cognition and behavior.

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Voyages of discovery / Allgrove, J. -- Physiology of calcium, phosphate, magnesium and vitamin D / Allgrove, J. -- Physiology of bone / Grabowski, P. -- Radiology of osteogenesis imperfecta, rickets and other bony fragility states / Calder, A.D. -- Bone densitometry : current status and future perspective / Crabtree, N.; Ward K. -- A practical approach to hypocalcaemia in children / Shaw, N.J. -- Approach to the child with hypercalcaemia / Davies, J.H. -- A practical approach to vitamin D deficiency and rickets / Allgrove, J.; Shaw, N.J. -- A practical clinical approach to pediatric phosphate disorders / Imel, E.A. ; Carpenter, T.O. -- Primary osteoporosis / Arundel, P. ; Bishop, N. -- Osteoporosis in children with chronic disease / Hgler, W. ; Ward, L. -- Genetics of osteoporosis in children / van Dijk, F.S. -- A practical approach to children with recurrent fractures / Korula, S.; Titmuss, A.T.; Biggin A.; Munns, C.F. -- Miscellaneous bone disorders / Mughal, M.Z.; Padidela, R. -- Skeletal aspects of non-accidental injury / Johnson, K.; Bradshaw, K. -- Skeletal dysplasias: an overview / Offiah, A.C -- Drugs used in paediatric bone and calcium disorders / Cheung, M.S. -- Classification of disorders of bone and calcium metabolism / Allgrove J. -- Case histories / Katugampola, H. ; Saraff, V.; Kumaran, A. ; Allgrove, J.; Shaw, N.J.

Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes -- Divers models of divalent cation interaction to calcium-binding proteins: Techniques and anthology -- Probing Ca2+-binding capability of viral proteins with the EF-hand motif by grafting approach -- New aspects of calmodulin-calmodulin binding domains recognition -- Purification and characterization of the human cysteine-rich S100A3 protein and its pseudo citrullinated forms expressed in insect cells -- X-ray structural analysis of S100 proteins -- Purification and stable isotope labeling of the calcium- and integrin-binding protein 1 for structural and functional NMR studies -- Analysis of calcium-induced conformational changes in calcium-binding allergens and quantitative determination of their IgE binding properties -- Longistatin, an EF-hand Ca2+-binding protein from vector tick: Identification, purification, and characterization -- Super-resolution microscopy of the neuronal calcium-binding proteins calneuron-1 and caldendrin -- NMR studies of the interaction of calmodulin with iq motif peptides -- Biochemical and immunological detection of physical interactions between penta-ef-hand protein ALG-2 and its binding partners -- Measuring binding of S100 proteins to RAGE by surface plasmon resonance -- Phage display selection of peptides that target calcium-binding proteins -- RAGE-mediated cell signaling -- RAGE splicing variants in mammals -- Screening for novel calcium-binding proteins that regulate cardiac hypertrophy: CIB1 as an example -- In vivo screening of S100B inhibitors for melanoma therapy -- Arrayed primer extension microarray for the analysis of genes associated with congenital stationary night blindness -- Nesfatin-1: Its role in the diagnosis and treatment of obesity and some psychiatric disorders -- Human cell line authentication: The critical first step in any project using human cell lines -- Detection of Ca2+-binding S100 proteins in human saliva by HPLC-ESI-MS -- Clinical use of the calcium-binding S100B protein -- Sensible use of high-sensitivity troponin assays -- S100a1 gene therapy in small and large animals.

Historical overview of store-operated Ca2+ entry -- The STIM1- Orai interaction -- The TRPCs, Orais and STIMs in ER/PM junctions -- The TRP-Na-Ca2+ exchanger coupling -- Role of TRPC channels in store-operated calcium entry -- Phospholipase A2 as a molecular determinant of store-operated calcium entry -- Extracellular calcium has multiple targets to control cell proliferation -- Regulation of platelet function by Orai, STIM and TRP -- On the roles of the Transient Receptor Potential Canonical 3 (TRPC3) channel in endothelium and macrophages: implications in atherosclerosis -- Second messenger-operated calcium entry through TRPC6 -- Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Nonselective Cation Channel -- Calcium entry through thermosensory channels -- Calcium signalling through ligand-gated ion channels such as P2X1 receptors in the platelet and other non-excitable cells -- The calcium entry-calcium refilling coupling -- Microdomains associated to lipid rafts -- Role of scaffolding proteins in the regulation of TRPC-dependent calcium entry -- Modulation of calcium entry by mitochondria -- Modulation of calcium entry by the endo-lysosomal system -- Remodeling of calcium entry pathways in cancer.

Preface Calcium signaling: from basics to bedside Md. Shahidul Islam Measuring Ca2+ in living cells Joseph Bruton, Arthur J Cheng & Håkan Westerblad High-throughput fluorescence assays for Ion Channels and GPCRs Irina Vetter, David Carter, John Bassett, Jennifer R. Deuis, Bryan Tay, Sina Jami, Samuel D. Robinson. Imaging Native Calcium Currents in Brain Slices Karima Ait Ouares, Nadia Jaafari, Nicola Kuczewski and Marco Canepari Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions. Luca Hegedűs, Boglárka Zámbó, Katalin Pászty, Rita Padányi, Karolina Varga, John T. Penniston, Ágnes Enyedi A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders Aikaterini Britzolaki, Joseph Saurine, Benjamin Klocke, Pothitos M. Pitychoutis Cytoplasmic Calcium Buffering: An Integrative Crosstalk Juan A. Gilabert An update on calcium binding proteins Jacobo Elíes, Matilde Yáñez, Thiago M.C. Pereira, José Gil-Longo, David A. MacDougall & Manuel Campos-Toimil Phospholipase C Colin A. Bill and Charlotte M. Vines New insights in the IP3 receptor and its regulation Jan B. PARYS & Tim VERVLIET Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans Fabian Nordenskjöld, Björn Andersson, Md. Shahidul Islam. Evolution of Excitation-Contraction Coupling John J. Mackrill and Holly A. Shiels Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels Naohiro Yamaguchi Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side Agustín Guerrero-Hernández, Víctor Hugo Sánchez-Vázquez, Ericka Martínez-Martínez, Lizeth Sandoval-Vázquez, Norma C. Perez-Rosas, Rodrigo Lopez-Farias, Adan Dagnino-Acosta Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores Antony Galione and Kai-Ting Chuang Calcium Signaling in the Heart Derek A. Terrar Molecular basis and regulation of store-operated calcium entry Jose J Lopez, Isaac Jardin, Letizia Albarrán, Jose Sanchez-Collado, Carlos Cantonero, Gines M Salido, Tarik Smani and Juan A. Rosado Structure and activation mechanisms of CRAC channels Carmen Butorac, Adéla Krizova, Isabella Derler Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells Yong-Xiao Wang, Lan Wang, and Yun-Min Zheng Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis Javier Avila-Medina, Isabel Mayoral-Sanchez, Isabel Galeano-Otero, Pedro C. Redondo, Juan A. Rosado, Tarik Smani Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels. Giorgio Santoni, Maria Beatrice Morelli, Oliviero Marinelli, Massimo Nabissi, Matteo Santoni, Consuelo Amantini. Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression. Giorgio Santoni, Maria Beatrice Morelli, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli and Consuelo Amantini Calcium channels and Calcium-regulated channels in human red blood cells Lars Kaestner, Anna Bogdanova, Stephane Egee Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting Kathryn Anne Skelding and John A. P. Rostas Widespread roles of CaMK-II in Developmental Pathways Sarah C. Rothschild and Robert M. Tombes Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance Koffi L. Lakpa, Peter Halcrow, Xuesong Chen and Jonathan D. Geiger At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor? Benjamin Delprat, Lucie Crouzier, Tsung-Ping Su, and Tangui Maurice ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases. Francesca Vallese, Lucia Barazzuol, Lorenzo Maso, Marisa Brini and Tito Calì The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells Andra M Sterea and Yassine El Hiani Calcium Signaling and Gene Expression Basant K. Puri Simulation Strategies for Calcium Microdomains and Calcium Noise Nicolas Wieder, Rainer H. A. Fink, Frederic von Wegner A statistical view on calcium oscillations Jake Powell, Martin Falcke, Alexander Skupin, Tomas C Bellamy, Theodore Kypraios and Rüdiger Thul Calcium Regulation of Bacterial Virulence M. King, B. Kayastha, M. J. Franklin, M.A. Patrauchan Ca2+ Signaling in Drosophila Photoreceptor Cells Olaf Voolstra and Armin Huber Calcium imaging in Drosophila melanogaster. Nicola Vajente, Rosa Norante, Paola Pizzo and Diana Pendin. Calcium imaging in the zebrafish Petronella Kettunen Stimulation-secretion coupling in the beta cells: from basic to bedside Md. Shahidul Islam Calcium dynamics and synaptic plasticity Pedro Mateos-Aparicio and Antonio Rodríguez-Moreno Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity Ashok Kumar Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease Francesco Moccia Sensing Extracellular Calcium -- An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) Sergei Chavez-Abiega, Iris Mos, Patricia P. Centeno, Taha Elajnaf, Wolfgang Schlattl, Donald T. Ward, Joachim Goedhart, Enikö Kallay Extracellular Ca2+ in bone marrow Ryota Hashimoto Calcium in Cell-Extracellular Matrix Interactions Sandeep Gopal, Hinke A. B. Multhaupt, John R. Couchman Index.

Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells / Lin Mei, Yun-Min Zheng, and Yong-Xiao Wang -- Kv7 (KCNQ) Potassium Channels and L-type Calcium Channels in the Regulation of Airway Diameter / Kenneth L. Byron, Lioubov I. Brueggemann, Priyanka P. Kakad, and Jennifer M. Haick -- Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells / Jun-Hua Xiao, Yong-Xiao Wang, and Yun-Min Zheng -- Large-conductance calcium-activated potassium channels / Hiroaki Kume -- Calcium-activated Chloride Channels / George Gallos and Charles W. Emala Sr. -- Local Calcium Signaling in Airway Smooth Muscle Cells / Quing-Hua Liu, Carlo Savoia, Yong-Xiao Wang -- Regulation of Airway Smooth Muscle Contraction by Ca2+ Signaling: Physiology Revealed by Microscopy Studies of Lung Slices / Michael J. Sanderson -- Temporal Aspects of Ca2+ Signaling in Airway Myocytes / Etienne Roux -- Mechanisms Underlying Ca2+ Store Refilling in Airway Smooth Muscle / Charlotte K. Billington, Ian P. Hall, and Carl P. Nelson -- Novel Mechanisms in Ca2+-homeostasis and Internal Store Refilling of Airway Smooth Muscle / Luke J. Janssen -- The Role of Mitochondria in Calcium Regulation in Airway Smooth Muscle / Philippe Delmotte, Li Jia, and Gary C. Sieck -- Role of Caveolae in the Airway / Christina M. Pabelick, Brij B. Singh, and Y.S. Prakash -- CD38 : Cyclic ADP-ribose-mediated Calcium Signaling in Airway Myocytes /Deepak A. Deshpande, Alonso Guedes, Mythili Dileepan, Timothy F. Walseth, and Mathur S. Kannan -- The Pathways and Signaling Cross-talk with Oxidant in Calcium Influx in Airway Smooth Muscle Cells / Lei Cai and Quinghua Hu -- Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions / Satoru Ito -- Role of Integrins in the Regulation of Calcium Signaling / Thai Tran and Chun Ming Teoh -- Sex Steroid Signaling in the Airway / Y.S. Prakash, Venkatachalem Sathish, and Elizabeth A. Townsend -- Regulation of Contractility in Immature Airway Smooth Muscle / Y.S. Prakash, Christina M. Pabelick, and Richard J. Martin -- Mathematical Modeling of Calcium Dynamics in Airway Smooth Muscle Cells / James Sneyd, Pengxing Cao, Xiahui Tan, and Michael J. Sanderson -- Effects of Inflammatory Cytokines on Ca2+ Homeostasis in Airway Smooth Muscle Cells / Hisako Matsumoto -- Ca2+ Signaling and P2 Receptors in Airway Smooth Muscle / Luis M. Montaño, Edgar Flores-Soto, and Carlos Barajas-López -- Calcium Signaling in Airway Smooth Muscle Remodeling / Tengyao Song, Yun-min Zheng, and Yong-Xiao Wang -- Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle / Deepak A. Deshpande and Stephen B. Liggett -- Modulation of Airway Smooth Muscle Contractile Function by TNFa and IL-13 and Airway Hyper-responsiveness in Asthma / Yassine Amrani -- Airway Smooth Muscle Malfunction in COPD / Yunchao Su.

Fluorescent measurement of [Ca2+]c : basic practical considerations / Alec W.M. Simpson -- Measurement of [Ca2+]i in whole cell suspensions using fura-2 / Anish Patel [and others] -- Confocal microscopy : theory and applications for cellular signaling / Stephen C. Tovey [and others] -- Ratiometric Ca2+ measurements using the FlexStation® scanning fluorometer / Ian C.B. Marshall, Izzy Boyfield, and Shaun McNulty -- Measuring Ca2+ changes in multiwell format using the fluorometric imaging plate reader (FLIPR®) / Ian C.B. Marshall, Davina E. Owen, and Shaun McNulty -- Ratiometric [Ca2+]i measurements in adherent cell-lines using the NOVOstar microplate reader / Benjamin D. Hunt and David G. Lambert -- Whole-cell patch-clamp recording of voltage-sensitive Ca2+ channel currents in single cells : heterologous expression systems and neurones / Jon Brown [and others] -- Combined calcium fluorescence recording with ionic currents in contractile cells / Richard D. Rainbow -- Measurement of phospholipase C by monitoring inositol phosphates using [3H]inositol labeling protocols in permeabilized cell / Alison Skippen, Philip Swigart, and Shamshad Cockcroft -- Single-cell imaging techniques for the real-time detection of IP3 in live cells / Carl P. Nelson -- Measurement of inositol(1,4,5)trisphosphate using a stereospecific radioreceptor mass assay / Darren Smart -- Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry / Hideo Kanaide and Katsuya Hirano -- Calcium measurements from whole heart using rhod-2 / Bum-Rak Choi -- Measurement of changes in endothelial and smooth muscle Ca2+ in pressurized arteries / Kim A. Dora and Michael A. Hill -- Single cell and subcellular measurements of intracellular Ca2+ concentration / John G. McCarron [and others] -- Simultaneous analysis of intracellular pH and Ca2+ from cell populations / Raul Martinez-Zaguilan [and others] -- Measurements of Ca2+ concentration with recombinant targeted luminescent probes / Denis Ottolini, Tito Calì, and Marisa Brini -- Chimeric G proteins in fluorimetric calcium assays : experience with opioid receptors / Valeria Camarda and Girolamo Calo -- Compartmentalizing genetically encoded calcium sensors / David A. Williams, Mastura Monif, and Kate L. Richardson -- Measurement of cytosolic-free Ca2+ in plant tissue / Martin R. McAinsh and Carl K.-Y. Ng -- Measurement of Ca2+-ATPase activity (in PMCA and SERCA1) / Danuta Kosk-Kosicka.

Summary -- Introduction -- Direct evidence - the digital approach -- Fluorescence-based visualisation -- Aequorin-based measurements -- Measurement of calcium transport across membranes -- Molecular biology based approaches -- Manipulation of calcium -- Calcium-induced function -- Calcium signalling in cardiac myocytes -- Calcium signalling in red blood cells -- Perspective -- Calcium Signalling Methodology -- Non-linear and ultra high-speed imaging for explorations of the murine and human heart -- A system for optical high resolution screening of electrical excitable cells -- Concepts for optical high content screens of excitable primary isolated cells -- A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes -- Calcium imaging of individual erythrocytes: Problems and approaches -- Calcium Signalling in Cardiac Myocytes -- Reduced Cardiac L-Type Ca²+ Current in Cav€ ₂ -/- Embryos Impairs Cardiac Development and Contraction With Secondary Defects in Vascular Maturation -- Overexpression of junctin causes adaptive changes in cardiac myocyte Ca²+ signaling -- Remodelling of Ca²+ handling organelles in adult rat ventricular myocytes during longterm culture -- Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement -- Calcium Signalling in Red Blood Cells -- The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterisation -- Ion channels in the human red blood cell membrane: Their further investigation and physiological relevance -- Prostaglandin E₂ activates channelmediated calcium entry in human erythrocytes: An indication for a blood clot formation supporting process -- Functional NMDA receptors in rat erythrocytes -- Stimulation of human red blood cells leads to Ca²+-mediated intercellular adhesion -- Lysophospatidic acid induced red blood cell aggregation in vitro -- Regulation of phosphatidylserine exposure in red blood cells -- Cation Channels in Erythrocytes - Historical and Future Perspective.

Calendar basics -- Part I. Arithmetical calendars -- The Gregorian calendar -- The Julian calendar -- The Coptic and Ethiopic calendars -- The ISO calendar -- The Icelandic calendar -- The Islamic calendar -- The Hebrew calendar -- The Ecclesiastical calendars -- The Old Hindu calendars -- The Mayan calendars -- The Balinese Pawukon calendar -- Generic cyclical calendars -- Part II. Astronomical calendars -- Time and astronomy -- The Persian calendar -- The Bahai calendar -- The French Revolutionary calendar -- Astronomical Lunar calendars -- The Chinese calendar -- The Modern Hindu calendars -- The Tibetan calendar -- Part III. Appendices.

Part 1. Reference and planning information -- Part 2. Facilities inventory.

Mechanical Alignment Total Knee Arthroplasty: A Thoughtful Beginning With Unanticipated Limitations -- Phenotypes of the Knee and Limb: Rationale for Transitioning Toward Personalized Alignment in Total Knee Arthroplasty -- It Is Time to Consider a Philosophical Change From Mechanical to Kinematic Alignment -- Preoperative Evaluation of the Patient for Treatment With a Calipered Kinematically Aligned Total Knee Arthroplasty -- Calipered Kinematic Alignment Total Knee Arthroplasty Performed With Specific Manual Instrumentation, Verification Checks, and a Decision Tree -- Calipered Kinematic Alignment Using Patient-Specific Instrumentation -- Calipered Kinematic Alignment With Navigation Instrumentation -- Kinematic Alignment With Image-Based Robotic Instrumentation -- Strategies for Improving Implant Design Based on Differences in Tibiofemoral Kinematics of a Low-Conforming Total Knee Arthroplasty Implanted With Calipered Kinematic Alignment and the Native Knee -- Strategies for Improving the Prosthetic Trochlea Design Based on Differences in Trochlea Morphology Between Femoral Components Set in Kinematic and Mechanical Alignment and the Native Knee Advantages of Kinematically Aligned Total Knee Arthroplasty: A Biomechanical Perspective -- Calipered Kinematically Aligned Total Knee Arthroplasty Closely Restores the Tibial Compartment Forces of the Native Knee -- Clinical Outcome, Postoperative Alignment, and Implant Survivorship After Kinematically Aligned Total Knee Arthroplasty -- Managing Severe Deformities With Calipered Kinematic Alignment -- Kinematic Alignment Technique for Unicompartmental Knee Arthroplasty -- Postoperative Management -- Reducing the Risk and Methods of Managing Stiffness After Calipered Kinematically Aligned Total Knee Arthroplasty -- Reducing the Risk and Management of Early and Late Tibial Component Failure After Calipered Kinematically Aligned Total Knee Arthroplasty -- Reducing the Risk and Management of Patellofemoral Instability After Calipered Kinematically Aligned Total Knee Arthroplasty -- Retaining the Posterior Cruciate Ligament and Restoring the Prearthritic Tibial Joint Line Reduces the Risk of Early-Onset Tibiofemoral Instability After Calipered Kinematically Aligned Total Knee Arthroplasty -- Revision Total Knee Arthroplasty Using Kinematic Alignment Principles.

Obstetric ultrasound examination -- Genetics and prenatal genetic testing -- Ultrasound evaluation of fetal aneuploidy in the first and second trimesters -- Ultrasound of the early first trimester -- Evaluation of fetal anatomy in the first trimester -- Fetal biometry and growth -- Ultrasound evaluation in multiple gestations -- Ultrasound evaluation of normal fetal anatomy -- Ultrasound evaluation of the fetal central nervous system -- Ultrasound evaluation of the fetal face and neck -- Fetal musculoskeletal system -- Ultrasound evaluation of the fetal thorax -- Sonographic evaluation of the fetal heart -- Ultrasound evaluation of the fetal gastrointestinal tract and abdominal wall -- Fetal genitourinary tract -- Ultrasound features of fetal syndromes -- Evaluation of hydrops fetalis -- Ultrasound evaluation of the gravid cervix -- Ultrasound evaluation of the placenta, membranes, and umbilical cord -- Amniotic fluid volume in fetal health and disease -- Antepartum fetal surveillance and the role of ultrasound -- Role of Doppler sonography in obstetrics -- Role of magnetic resonance imaging in obstetrics -- Role of sonography in fetal procedures -- Obstetric ultrasound imaging and the obese patient -- Normal anatomy of the female pelvis and transvaginal sonography -- Abnormal uterine bleeding : the role of ultrasound -- Ultrasound evaluation of the uterus -- Evaluation of pelvic pain in the reproductive age patient -- Ultrasound evaluation of the ovaries -- Ultrasound evaluation of the fallopian tube -- Sonographic imaging in infertility and assisted reproduction -- Ectopic pregnancy -- Gynecologic sonography in the pediatric and adolescent patient -- Ultrasound and magnetic resonance imaging in urogynecology -- Role of magnetic resonance imaging in the evaluation of gynecologic disorders -- Role of sonography in gynecologic interventions -- Artifacts, pitfalls, and normal variants -- Appendices. Measurements frequently used to estimate gestational age and fetal biometry -- Measurements used in assessing fetal weight, growth, and body proportions -- Measurements for amniotic fluid assessment -- Fetal Doppler assessment (noncardiac) -- Doppler of the middle cerebral artery to assess fetal anemia -- Fetal cardiac measurements and Doppler assessment -- Sonographic detection of chromosomal abnormalities -- Medications and reported associated malformations -- Estimated radiation exposure to the fetus during radiographic examinations -- Magnetic resonance imaging of the female pelvis: representative protocols.

"The world is awash in bullshit, and we're drowning in it. Politicians are unconstrained by facts. Science is conducted by press release. Startup culture elevates bullshit to high art. These days, calling bullshit is a noble act. Based on Carl Bergstrom and Jevin West's popular course at the University of Washington, Calling Bullshit is a modern handbook to the art of skepticism. Bergstrom, a computational biologist, and West, an information scientist, catalogue bullshit in its many forms, explaining and offering readers the tools to see through the obfuscations, deliberate and careless, that dominate every realm of our lives. They instruct readers to ask: Who is saying it? How do they know? What do they have to gain by persuading me? Are the numbers or results too good or too dramatic to be true? Is the claim comparing like with like or apples and oranges? Is it confirming your personal bias? In this lively guide to everything from misleading statistics to "fake news," Bergstrom and West help you recognize bullshit whenever and wherever you encounter it--in data, in conversation, even within yourself--and explain it to your crystal-loving aunt or casually racist uncle. Now more than ever, calling bullshit is crucial to a properly functioning community, whether it be a circle of friends, a network of academics, or the citizenry of a nation"-- Provided by publisher.

Front Cover -- Title Page -- Copyright -- Authors and Contributors -- Dedication -- Contents -- Foreword Andrea Childers, RN, BSN, CPN -- Acknowledgments -- Introduction -- Chapter 1. What Is Colic? -- Chapter 2. Is It Colic or Something Else? -- Chapter 3. Why Do Babies Cry? -- Chapter 4. Reading Cues: What Is Your Baby Saying? -- Chapter 5. Your Baby's Sensory World -- Chapter 6. Your Baby's Arousal Levels -- Chapter 7. Attachment and the Parent-Baby Relationship -- Chapter 8. A Calming Touch: Baby Massage -- Chapter 9. The Secret of Sleep --Chapter 10. Feeding Challenges and the Fussy Baby -- Chapter 11. Infantile Colic: Can Diet Help? -- Chapter 12. Understanding Your Baby's Postural Control -- Chapter 13. The Postpartum Family -- Chapter 14. Beyond Colic: Disorders in Babies Older Than 6 Months -- A CALMing Last Word -- Resources -- Index -- Back Cover.

"The Camberwell Assessment of Need (CAN) is a standardised measure for assessing the needs of people experiencing severe and/or enduring mental health problems. It covers a wide range of health and social needs, and incorporates staff, service user and informal carer perspectives. The CAN was developed for use by three groups: a) mental health workers involved in planning care for people with severe mental health problems b) mental health service users in rating their own needs c) people wanting to evaluate mental health services. The first edition of the CAN was published in 1995 by the Section of Community Psychiatry (PRiSM) at what is now called the Institute of Psychiatry, Psychology and Neuroscience in London, England. The accompanying book was published in 1999 by Gaskell, the imprint of the Royal College of Psychiatrists"-- Provided by publisher.

"The Camberwell Assessment of Need for adults with Developmental and Intellectual Disabilities (CANDID) is a needs assessment scale specifically designed for people with intellectual disabilities (previously known as learning disabilities, mental retardation, mental handicap or mental impairment) and mental health problems. The CANDID was developed at what was then known as the Institute of Psychiatry, London (now the Institute of Psychiatry, Psychology and Neuroscience). It was developed by modification of the Camberwell Assessment of Need (CAN), an established needs assessment scale for people with severe and enduring mental illness (Slade 1999). The validity and reliability of the CAN and CANDID have been investigated by Phelan et al (1995) and Xenitidis et al (2000) respectively, and were found to be acceptable. The 1st edition of the CANDID book was published in 2003 by Gaskell, the imprint of the Royal College of Psychiatrists"-- Provided by publisher.

"Scientific research on the psychology of women reveals the intersectionality of women's experiences relative to those of men. There is a growing knowledge base in understanding the differences and similarities between women and men, as well as the diversities among women and sexualities. Although genetic and biological characteristics define human beings conventionally as women and men, their experiences are contextualized in multiple dimensions in terms of gender, sexuality, class, age, ethnicity and other social dimensions. Beyond the biological and genetic basis of gender differences, gender intersects with culture and other social locations which affect the socialization and development of women across their life span"-- Provided by publisher.

"This work brings together a wealth of data regarding the reference values and factors of variation in biochemical parameters used by camel veterinarians and scientists to determine these animals' nutritional and clinical status. It also explores several technical aspects involved in determining these parameters, sampling procedures, and essential elements in the interpretation of the results. Though many texts are available on small and large ruminants, much less is known about species confined to the marginal zones of tropical and Mediterranean countries, such as camels. This book addresses precisely this research gap, on the one hand by presenting an extensive review of the literature, and on the other by synthesizing the outcomes of the authors' numerous previous works. In veterinary medicine, blood tests to help diagnose diseases in cattle were first proposed nearly a century ago, but were mainly developed in the 1960s, initially at specialized research or veterinary services laboratories, and eventually, with the advent of new equipment and the miniaturization of the analyzers, finding their way into veterinarians' cabinets. Beyond their diagnostic value, veterinary surgeons and zootechnicians also speculated on the potential use of blood tests to evaluate animals' nutritional status. Thus, a whole range of analyses are now proposed to the stakeholders responsible for animal health. Such analyses could help to define a metabolic profile, which would offer a valuable decision-making tool for experts and researchers alike."-- Provided by publisher.

Simultaneous assessment of cAMP signaling events in different cellular compartments using FRET-based reporters / Alex Burdyga and Konstantinos Lefkimmiatis -- Recording intracellular cAMP levels with EPAC-based FRET sensors by fluorescence lifetime imaging / Marcel Raspe, Jeffrey Klarenbeek, and Kees Jalink -- Novel approach combining real-time imaging and the patch-clamp technique to calibrate FRET-based reporters for cAMP in their cellular microenvironment / Andreas Koschinski and Manuela Zaccolo -- Structure-based, in silico approaches for the development of novel cAMP FRET reporters / Matías Machado and Sergio Pantano -- Automated image analysis of FRET signals for subcellular cAMP quantification / Silas J. Leavesley [and others] -- Channel-based reporters for cAMP detection / Thomas C. Rich [and others] -- Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters / Anders Tengholm and Olof Idevall-Hagren -- Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes / Oliver Lomas [and others] -- Generation of transgenic mice expressing FRET biosensors / Daniela Hübscher and Viacheslav O. Nikolaev -- Photoactivatable adenylyl cyclases (PACs) as a tool to study cAMP signaling in vivo : an overview / Marina Efetova and Martin Schwärzel -- Selective disruption of the AKAP signaling complexes / Eileen J. Kennedy and John D. Scott -- Screening for small molecule disruptors of AKAP-PKA interactions / Carolin Schächterle [and others] -- Structure-based bacteriophage screening for AKAP- selective PKA regulatory subunit variants / Ryan Walker-Gray and Matthew G. Gold -- Yeast-based high-throughput screen for modulators of phosphodiesterase activity / Ana Santos de Medeiros and Charles S. Hoffman -- Separation of PKA and PKG signaling nodes by chemical proteomics / Eleonora Corradini, Albert J.R. Heck, and Arjen Scholten -- Development of computational models of cAMP signaling / Susana R. Neves-Zaph and Roy S. Song.

Ideal for orthopaedic surgeons who need a practical resource covering the top procedures in the field, Campbell's Core Orthopaedic Procedures utilizes a succinct format that focuses solely on the surgical techniques critical in helping achieve optimal patient outcomes. Featuring step-by-step procedures used at the Campbell Clinic, this new resource offers practical, concise solutions for every patient scenario.

"Continuing in a great tradition of publishers, editors, and authors, we proudly present to you, our readers, the twelfth edition of the "Bible of Urology"-- Campbell-Walsh-Wein Urology . Started in 1954 as Campbell's Urology and retitled Campbell-Walsh Urology in 2012, the present editors felt it was appropriate to honor Alan J. Wein, MD, PhD (Hon) for his many years of dedication to this text by adding his name to the previous chief editors. During his time as chief editor, Dr. Wein was responsible for keeping the textbook in pace with a rapidly growing field in medicine--for this diligence and dedication we are grateful. As with previous editions, the twelfth edition presents many exciting advances in our use and understanding of technology, physiology, pharmacology, epidemiology, and pathophysiology while maintaining our basic classical urological knowledge"--Preface.

History of surgery for limb bone tumors -- Non-Surgical Treatment Of Pediatric Bone Sarcomas -- Molecular Biology of Pediatric Bone Sarcomas -- Limb Salvage in Skeletally Immature Patients with Extremity Sarcoma -- Location of Sarcomas Within Bone: The Growth Plate -- A Histological Study of the Barrier Effect of the Physis Against Metaphyseal Osteosarcoma -- Growth Plate Involvement in Malignant Bone Tumours: Relationship Between Imaging Methods and Histological Findings -- Consequences of Delayed Diagnosis -- Imaging-Based Indications for Resection with Epiphyseal Preservation -- Conservation of the Epiphysis While Removing Metaphyseal Bone Tumors: Epiphysiolysis Before Excision -- Complications of the technique and solutions -- Clinical Results -- Other Techniques for Epiphyseal Preservation -- Worldwide Experience with the Cañadell Technique -- Questions and Answers.

v. 1. Etiology : chemical and physical carcinogenesis.

This comprehensive, ground-breaking title presents, in simplifying style, the driving and organizing principles of cancer, making this multidimensional, highly complex disease easily understandable for readers. Developed out of the renowned author's many years of teaching a widely popular, several-hundred-student college course, this 12-chapter book begins with an account of the history of cancer as a medical and public health problem, as well as the major milestones and setbacks in the ongoing quest to understand the wide variety of cancers that continue to impact the world. Subsequent chapters then address pathogenesis, incidence and mortality statistics, risk factors, causal factors, screening challenges and victories, treatment strategies, and disease prevention approaches. This wealth of clinical information is further supplemented with socioeconomic discussions on the financial, social, ethical, technological, regulatory, political, and logistical challenges that limit progress in cancer research. A soon to be gold-standard text that thoroughly and expertly describes cancer as a composite, adaptive system, Cancer: The Enemy from Within equips and empowers all undergraduate students and graduate students to better understand this continually perplexing disease. Clinicians across all disciplines may also find this work of great interest.

1. Introduction -- 2. Awareness and paying attention -- 3. The value of paying attention -- 4. Relevant aspects of sexuality -- 5. The various levels of impact -- 6. A comprehensive guideline on sexual care in case of cancer -- 7. Training in oncosexology -- 8. Sexual consequences of the various process phases -- 9. Psychosexual consequences of cancer diagnosis -- 10. Sexual consequences of pelvic radiotherapy -- 11. Sexual consequences of chemotherapy -- 12. The sexual consequences of cancer surgery -- 13. Sexual consequences of cancer medication and cancer-related medication -- 14. Sexual aspects of specific cancers -- 15. Breast cancer and sexuality -- 16. Sexual function after gynaecological cancer -- 17. Prostate cancer -- 18. Sexual problems related to bladder cancer -- 19. Sexual consequences to testicular cancer -- 20. Penile cancer and sexuality -- 21 Colorectal and anal cancer -- 22. Blood and lymph node cancer -- 23. Sexual consequences of head and neck cancer -- 24. "Dealing with" -- 25. Couple sexual rehabilitation -- 26. Male sexual rehabilitation after pelvic cancer -- 27. Sexual rehabilitation after gyneacological cancers -- 28. Sexual tools and toys in oncosexology -- 29. Special groups -- 30. The partner -- 31. The impact of cancer treatment on sexuality and relationships for the teenage and young adult cancer survivors -- 32. Sexuality and cancer in the aged/aging population -- 33. Homosexual men and women, cancer, and the health care system -- 34. Sexuality and intimacy at the end of life.

Chronic mechanistic target of rapamycin inhibition : preventing cancer to delay aging, or vice versa? / Sharp, Z.D.; Curiel, T.J.; Livi, C. -- Senescent cells and their secretory phenotype as targets for cancer therapy / Velarde, M.C.; Demaria, M.; Campisi, J. -- Cancer vaccination at older age / Gravekamp, C. -- Immunology of aging and cancer development / Fulop, T. ... [et al.] -- Metabolic syndrome and cancer : from bedside to bench and back / Extermann, M. -- Frailty : a common pathway in aging and cancer / Balducci, L. -- Targeting age-related changes in the biology of acute myeloid leukemia : is the patient seeing the progress? / Vey, N. -- Comprehensive geriatric assessment in oncology / Mohile, S.G.; Magnuson, A. -- Pharmacology of aging and cancer : how useful are pharmacokinetic tests? / Lichtman, S.M. -- Surgery in older cancer patients : recent results and new techniques : worth the investment? / Van Leeuwen, B.L.; Huisman, M.G.; Audisio, R.A. -- Organizing the geriatrician/oncologist partnership : one size fits all? practical solutions / Holmes, H.M.; Albrand, G. -- Geriatric oncology nursing : beyond standard care / Overcash, J. -- Exercise for older cancer patients : feasible and helpful? / Klepin, H.D.; Mohile, S.G. ; Mihalko, S. -- Aging and cancer : addressing a nation's challenge / Brochot, J.-M.; Le Quellec-Nathan, M.; Buzyn, A.

The atlas provides a clear, concise, yet comprehensive review of common cardiovascular diseases occurring in patients with cancer. Cancer and cardiovascular disease are the two most common conditions worldwide. In clinical practice we frequently encounter patients who have established cardiovascular disease and subsequently develop cancer or are survivors of cancer with subsequent cardiovascular complications related to chemotherapy and or radiation. Most of the chapters are case based, followed by images and a discussion on current (evidence based, wherever available) investigations and treatment outline.

1. What is comorbidity? -- 2. How do we measure comorbidity? -- 3. Cancer, chronic conditions and social disadvantage--the perfect storm -- 4. Impact of comorbidity on cancer screening and diagnosis -- 5. Impact of comorbidity on treatment decision making and outcomes -- 6. The impact of cancer and chronic conditions on caregivers and family members -- 7. Prevention of chronic conditions and cancer -- 8. Chronic condition management models for cancer care and survivorship -- 9. The mamangement of polypharmacy in people with cancer and chronic conditions -- 10. Breaking the silos: integrated care for cancer and chronic conditions -- 11. Advocacy in cancer and chronic conditions--challenges and opportunities -- 12. Research considerations in patients with cancer and comorbidity -- 13. The cost of cure: chronic conditions in survivors of child, adolescent, and young adult cancers -- 14. Chronic conditions and cancer in older adults -- 15. Chronic conditions and cancer at the end of life.

1. Demographics of cancer in the reproductive age male -- 2. Demographics of cancer in the reproductive age female -- 3. Physiology of spermatogenesis: opportunities for disruption -- 4. Fertility assessment in the male -- 5. Fertility assessment in the female -- 6. Fertility conditions associated with cancer development -- 7. Chemotherapy and fertility -- 8. Radiation therapy and fertility -- 9. Sperm banking for cancer patients --10.Fertility preservation strategies in the male cancer patient -- 11. Fertility preservation in the female cancer patient -- 12. Cancer treatment in pregnancy -- 13. Surgical approaches for sperm harvest in the azoospermic cancer patient -- 14. Stem cells and fertility -- 15. The role of assisted reproduction in the cancer patient -- 16. Third party reproduction -- Index.

Infection, inflammation, and cancer: overview / Hiroshi Ohshima, Noriyuki Miyoshi, and Susumu Tomono -- Stem cell theory and inflammation-related cancer / Toshihiko Tanno and William Matsui -- Epithelial-mesenchymal transition: a link between cancer and inflammation / Jonas Fuxe and Mikael C.I. Karlsson -- Role of nitrative DNA damage in inflammation-related carcinogenesis / Yusuke Hiraku and Shosuke Kawanishi -- Lipid peroxidation-derived DNA adducts and the role in inflammation-related carcinogenesis / Helmut Bartsch and Urmila Jagadeesan Nair -- Level of inflammation-related DNA adducts in human tissues / Tomonari Matsuda, Pei-Hsin Chou, and Haruhiko Sugimura -- Toll-like receptors: role in inflammation and cancer / Sarang Tartey and Osamu Takeuchi -- Inflammasomes and inflammation / Kaiwen W. Chen, Ayanthi A. Richards, Alina Zamoshnikova, and Kate Schroder -- Activation-induced cytidine deaminase: an intrinsic genome modulator in inflammation-associated cancer development / Hiroyuki Marusawa and Tsutomu Chiba -- MicroRNA and inflammation-related cancer / Zhaojian Gong, Zhaoyang Zeng, Pranab Behari Mazumder, Jian Ma, Ming Zhou, Xiayu Li, Xiaoling Li, Wei Xiong, Yong Li, and Guiyuan Li -- Inflammation as a niche for tumor progression / Futoshi Okada -- Human papillomavirus and cervical cancer / Kurt J. Sales -- Hepatitis viruses and hepatocellular carcinoma / Wai-Kay Seto, Ching-Lung Lai, and Man-Fung Yuen -- Epstein-Barr virus and nasopharyngeal carcinoma / Xiaoying Zhou, Xue Xiao, Fu Chen, Tingting Huang, and Zhe Zhang -- Barrett's esophagus and esophageal cancer / Albert Roessner and Angela Poehlmann -- Asbestos-induced chronic inflammation and cancer / Andrea Napolitano, Sandro Jube, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, and Haining Yang -- Nanomaterials / Yiqun Mo, Rong Wan, David J. Tollerud, and Qunwei Zhang -- Inflammatory pathways of radiation-induced tissue injury / Danae A. Laskaratouu, Ifigeneia V. Mavragani, and Alexandros G. Georgakilas -- Photocarcinogenesis and inflammation / Chikako Nishigori -- Chemoprevention of colorectal cancer by anti-inflammatory agents / Michihiro Mutoh, Mami Takahasi, and Keiji Wakabayashi -- Nutraceuticals and colon cancer prevention / Deepak Poudyal and Lorne J. Hofseth -- Cancer chemoprevention by targeting cox-2 using dietary phytochemicals / Kyung-Soo Chun and Young-Joon Surh -- Regulation of inflammation-associated intestinal diseases with phytochemicals / Akira Murakami.

While a number of books have looked at the intersection between human health in general and other topics, such as climate change or diet, this book focuses specifically on cancer as it impacts and is impacted by social justice issues. The massive explosion of research knowledge of cancer immunology and genomics is holding out great promise of therapeutic advances, yet other human actions—climate change, pollution, business decisions, advertising – are fostering health inequalities as well as increasing risks. Those involved in cancer care and research are in a unique position to let their experiences and knowledge inform the public, yet very often have not taken strong public roles when it comes to discussing issues surrounding tobacco, climate change and health risks, financial toxicity of treatments, and diet choices. Written by a multidisciplinary team of authors and for medical oncologists, cancer researchers, occupational health workers, and related medical students, residents, and fellows, this book encourages oncologists to address public health care and the societal issues associated with cancer risk. This volume discusses the overarching theme of environmental justice and oncology, focuses on business and cancer (such as clinical trials, drug development and profits, and global disparities), as well as animals and cancer. .

Part 1. Powers of the zebrafish model. Uncharted waters: zebrafish cancer models navigate a course for oncogene discovery / Craig J. Ceol and Yariv Houvras -- The toolbox for conditional zebrafish cancer models / Marie Mayrhofer and Marina Mione -- Approaches to inactivate genes in zebrafish / John M. Parant and Jing-Ruey Joanna Yeh -- Tumor suppressors in zebrafish: from TP53 to PTEN and beyond / Jeroen den Hertog -- Identifying novel cancer therapies using chemical genetics and zebrafish / Michelle Dang, Rachel Fogley, and Leonard I. Zon -- Genomic approaches to zebrafish cancer / Richard M. White -- Transcriptomic analyses in zebrafish cancer models for global gene expression and pathway discovery / Xiaoqian Huang, Ira Agrawal, Zhen Li, Weiling Zheng, Qingsong Lin, and Zhiyuan Gong -- zebrafish discoveries in cancer epigenetics / Yelena Chernyavskaya, Brandon Kent, and Kirsten C. Sadler -- Lymphatics, cancer and zebrafish / Jonathan W. Astin and Philip S. Crosier -- In vivo imaging of cancer in zebrafish / Myron S. Ignatius, Madeline Hayes, and David M. Langenau -- Imaging cancer angiogenesis and metastasis in a zebrafish embryo model / C. Tulotta, S. He, W. van der Ent, L. Chen, A. Groenewoud, H. P. Spaink, and B. E. Snaar-Jagalska -- Allograft cancer cell transplantation in zebrafish / John C. Moore and David M. Langenau -- The zebrafish xenograft platform: evolution of a novel cancer model and preclinical screening tool / Jaime Wertman, Chansey J. Veinotte, Graham Dellaire, and Jason N. Berman -- Automation of technology for cancer research / Wietske van der Ent, Wouter J. Veneman, Arwin Groenewoud, Lanpeng Chen, Claudia Tulotta, Pancras C.W. Hogendoorn, Herman. P. Spaink, and B. Ewa Snaar-Jagalska -- part 2. Cancer models in fish. zebrafish models of human leukemia: technological advances and mechanistic insights / Nicholas R. Harrison, Fabrice J.F. Laroche, Alejandro Gutierrez, and Hui Feng -- Zebrafish Rhabdomyosarcoma / Michael Phelps and Eleanor Chen -- Baiting for cancer: using the zebrafish as a model in liver and pancreatic cancer / Katie L. Hwang and Wolfram Goessling -- Focusing the spotlight on the zebrafish intestine to illuminate mechanisms of colorectal cancer / Viola H. Lobert, Dmitri Mouradov, and Joan K. Heath -- zebrafish Melanoma / Charles K. Kaufman -- Neuroblastoma and its zebrafish model / Shizhen Zhu and A. Thomas Look -- zebrafish germ cell tumors / Angelica Sanchez and James F. Amatruda -- Malignant peripheral nerve sheath tumors / Adam D. Durbin, Dong Hyuk Ki, Shuning He, and A. Thomas Look -- Xiphophorus and medaka cancer models / Manfred Schartl and Ronald B. Walter.

This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Cancer Biology and Advances in Treatment is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Tissue Engineering and Regenerative Medicine and Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.

Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.

The ability to measure and monitor cancer biomarkers in "body fluid biopsy" should greatly impact oncologic practice. "Biomarkers in Proximal Fluids", the third of the "Cancer Biomarkers in Body Fluids" series details cancer signatures in none or minimally circulating body fluids including saliva, sputum, bronchoalveolar lavage fluid, exhaled breath condensate, nipple aspirate fluid, gastric and pancreatic juice, stool, urine, and prostatic, peritoneal and cerebrospinal fluid. These fluids are enriched with biomarkers, especially those emanating from cells of the proximal tissue. Chapter 1 examines the global burden of cancer and the need for regional efforts at primary prevention, early detection and patient care. Chapters 2-12 address tissue-specific biomarkers in associated body fluids. The tumor interstitial fluid as a microenvironment rich in cancer biomarkers is detailed in chapter 13, while chapter 14 looks at the human body fluid microbiome and its evolving role in cancer. Commercially available assays using proximal fluids are examined at the end of the respective chapters. This book complements its predecessors and is equally useful to oncologists, cancer researchers, clinicians, medical students, nurses, diagnostic laboratory and pharmaceutical industry personnel.

Medical Care in Countries in Transition -- How to Prioritize Cancer Care for Countries in Transition -- Cancer Trends and Risk Factors in Morocco -- The Magic of Dreams: Conflicts and Quandaries Within Multicultural Societies in Transition -- Modeling Integrative Oncology for the Arab Population in Northern Israel -- Cancer Care in Palestine -- Influx of Foreign Refugees to Jordan and its Overall Burden on Cancer Care -- Caring For Children With Cancer In A Country Conflicted With Massive Refugee Migration: Jordan as an Example -- Challenges and Future Trends for Cancer Care in Egypt -- Cancer Care in Lebanon, New Trends and Challenges -- Cancer Care in an economically torn country: Cyprus -- Cancer Care in a Country Undergoing Transition: Turkey. Current Challenges and Trends for the Future -- Cancer Care in Sudan: Current Situation and Challenges -- Cancer care in Countries in Transition in Africa; the case of Uganda -- Cancer Care in Pakistan -- Cancer Care in India -- Cancer Care in Afghanistan -- Kazakhstan -- An overview of cancer care in societies in transition- Global perspectives: UAE Experience -- Cancer care in countries in transition: The Islamic Republic of Iran -- Cancer Care in Regions/Societies in Transition in the Gulf States: Sultanate of Oman -- Challenges and prospects in cancer care in Georgia -- Romania: Attempting to Catch up the European standards of care for cancer patients -- Recent challenges and achievements in cancer care in Latin American societies -- Caring for Refugees with Cancer: A Case for Training of US Oncology Professionals -- University of Texas MD Anderson Cancer Center Experience caring for patients from countries undergoing political-social conflict -- Forty Years Fast Forward: Vietnamese Refugees in the United States with Comments on their Cancer Care -- The current state of cancer care in North America -- Application of genetic testing for childhood cancers in emerging countries -- Cancer Care among Immigrants to North America -- Promoting Cancer Nursing Education, Training and Research in Countries in Transition.

This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.

Use of Biguanides to Improve Response to Chemotherapy -- Evaluating Response to Metformin/Cisplatin Combination in Cancer Cells Via Metabolic Measurement and Clonogenic Survival -- Quantifying the Autophagy-Triggering Effects of Drugs in Cell Spheroids with Live Fluorescence Microscopy -- Interdependency Between Genetic and Epigenetic Regulatory Defects in Cancer -- Experimental Strategies to Manipulate the Cellular Levels of the Multifunctional Factor CTCF -- Use of Serum-Circulating miRNA Profiling for the Identification of Breast Cancer Biomarkers -- Prostate Cancer Detection Using a Non-Invasive Method for Quantifying mi RNAs -- DNA Methylation Analysis of Steroid Hormone Receptor Genes -- Control of Oncogenic mi RNA Function by Light-Activated mi RNA Antagomirs -- Methods for the Study of Long Non-Coding RNA in Cancer Cell Signaling -- Microvesicles as Mediators of Intercellular Communication in Cancer -- In Vivo Rat Model to Study Horizontal Tumor Progression -- An In Vivo Model to Study the Effects of Tumoral Soluble Factors on the Vascular Permeability in Mice -- Use of the Tumor Repressor DEDD as a Prognostic Marker of Cancer Metastasis -- Zebrafish-Based Systems Pharmacology of Cancer Metastasis -- A Flow Cytometry-Based Assay for the Evaluation of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in Cancer Cells -- Gene Disruption Using Zinc Finger Nuclease Technology.

Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Throughout the past decade, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer.

Section 1 Malignant hematology and hematopoietic cell transplantation -- Part 1 Acute lymphoblastic leukemia in adults -- Part 2 Acute myeloid leukemia in adults -- Part 3 Myelodysplastic syndromes and related disorders -- Part 4 Myeloproliferative neoplasms -- Part 5 Chronic lymphocytic and other leukemias -- Part 6 Hodgkin Lymphoma -- Part 7 Non-Hodgkin's lymphomas -- Part 8 Plasma cell neoplasms and related disorders -- Part 9 Special issues in hematology -- Part 10 Special issues in hematopoietic cell transplantation -- Section 2 Oncology -- Part 1 Central nervous system tumors -- Part 2 Head and neck cancers and thoracic malignancies -- Part 3 Breast cancer -- Part 4 Gastrointestinal oncology -- Part 5 Genitourinary oncology -- Part 6 Skin malignancies -- Part 7 Gynecological malignancies -- Part 8 Sarcomas -- Part 9 Multidisciplinary approach: consultation with surgical oncology team -- Part 10 Multidisciplinary approach: consultation with radiation oncology team -- Part 11 Hereditary cancer syndromes and genetic testing in oncology -- Part 12 Special issues in hematology and oncology.

This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.

This book offers a wide-ranging description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. The book opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention these fines are playing an important role in changing the landscape for pharmaceutical safety.

Cancer epigenetics : an introduction / Rajnee Kanwal, Karishma Gupta, and Sanjay Gupta -- Community resources and technologies developed through the NIH roadmap epigenomics program / John S. Satterlee ... [et al.] -- Epigenome-wide association studies (EWAS) : past, present, and future / James M. Flanagan -- Epigenetic biomarkers in liver cancer / Krishna K. Banaudha and Mukesh Verma -- Cancer type-specific epigenetic changes : gastric cancer / Danielle Queiroz Calcagno, Marília de Arruda Cardoso Smith, and Rommel Rodriguez Burbano -- Beyond the island : epigenetic biomarkers of colorectal and prostate cancer / Andrea J. Savio and Bharati Bapat -- Prostate cancer epigenome / Swathi Chinaranagari ... [et al.] -- CpG island hypermethylation as a biomarker for the early detection of lung cancer / Yujin Kim and Duk-Hwan Kim -- Analysis of DNA methylation in pancreatic cancer : an update / Christian Pilarsky and Robert Grützmann -- Epigenetics of urothelial carcinoma / Wolfgang A. Schulz ... [et al.] -- Epigenetics of prostate cancer / Tawnya C. McKee and James V. Tricoli -- Methylation profile landscape in mesothelioma : possible implications in early detection, disease progression, and therapeutic options / Xinbo Zhang ... [et al.] -- Techniques to access histone modifications and variants in cancer / Monica Tyagi ... [et al] -- Single base resolution analysis of 5-methylcytosine and 5-hydroxymethylcytosine by RRBS and TAB-RRBS / Maria A. Hahn ... [et al.] -- Quantitative DNA methylation analysis for epigenotyping of colorectal cancer / Atsushi Kaneda and Koichi Yagi -- Histone modifications associated with cancer cell migration and invasion / Miki Hieda, Nariaki Matsuura , and Hiroshi Kimura -- Aberrant epigenetic modifications in radiation-resistant head and neck cancers / Hon-Yi Lin, Tim Hui-Ming Huang, and Michael Wing-Yan Chan -- Cancer-associated infectious agents and epigenetic regulation / Vidya Vedham and Mukesh Verma -- Toxicoepigenomics and cancer : implications for screening / Mukesh Verma -- Human papilloma virus (HPV) modulation of the HNSCC epigenome / Josena K. Stephen and Maria J. Worsham -- Epigenetic regulation of HIV, AIDS, and AIDS-related malignancies / Mukesh Verma -- Epigenetics of colorectal cancer / Wenji Yan and Mingzhou Guo -- Epigenetics in breast and prostate cancer / Yanyuan Wu, Marianna Sarkissyan, and Jaydutt V. Vadgama -- Epigenetic inhibitors / Mukesh Verma and Hirendra Nath Banerjee -- Use of epigenetic modulators as a powerful adjuvant for breast cancer therapies / Aurore Claude-Taupin ... [et al.] -- Epigenetic approaches in glioblastoma multiforme and their implication in screening and diagnosis / Gwyneth Hyman ... [et al.] -- Detection of circulatory microRNAs in prostate cancer/ Anvesha Srivastava ... [et al.] -- Identification and characterization of small-molecule inhibitors of lysine acetyltransferases / Daiqing Liao -- Epigenetic regulation in biopsychosocial pathways / Kristin Litzelman and Mukesh Verma -- Viral epigenetics / Barry I. Milavetz and Lata Balakrishnan -- P53 tumor suppression network in cancer epigenetics / Alok Mishra, Daniel J. Brat, and Mukesh Verma -- Promoter hypermethylation as a biomarker in prostate adenocarcinoma / Jong Y. Park -- Sequencing the cancer methylome / Austin Y. Shull ... [et al.] -- Global DNA methylation profiling technologies and the ovarian cancer methylome / Jessica Tang ... [et al.] -- Recent progress in the discovery of epigenetic inhibitors for the treatment of cancer / Sharad K. Verma -- At the crossroad between obesity and gastric cancer / Jone Garai ... [et al.] -- Detection of epigenetic aberrations in the development of hepatocellular carcinoma / Yujing Zhang -- Specific type epigenetic changes in cervical cancers / Shuping Zhao -- Epigenetics in head and neck cancer / Syeda Marriam Bakhtiar, Amjad Ali, and Debmalya Barh -- Epigenetic therapy for colorectal cancer / Vivek Vaish ... [et al.] -- Epigenetics of gastric cancer / Mingzhou Guo and Wenji Yan.

"A guide and comprehensive reference for the care of patients with hereditary cancer syndromes. This book is intended to provide the essential tools needed to understand clinical cancer genetics"-- Provided by publisher.

The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Genomic Pathology of Lung Cancer / Kenneth J. Craddock, Shirley Tam, Chang-Qi Zhu, Ming-Sound Tsao -- Understanding Melanoma Progression by Gene Expression Signatures / J. Tímár, T. Barbai, B. Győrffy, E. Rásó -- Prognostic Testing in Uveal Melanoma / Michael Zeschnigk, Dietmar R. Lohmann -- Capturing and Deciphering the Molecular Signatures of Head and Neck Cancer / Thomas J. Belbin, Roberto A. Lleras, Richard V. Smith -- Predictive and Prognostic Biomarkers for Colorectal Cancer / Lara Lipton, Michael Christie, Oliver Sieber -- Expression Profiling of Hepatocellular Carcinoma / Rosina Maria Critelli, Elisabetta Cariani, Erica Villa -- Kidney Cancer Genomics: Paving the Road to a New Paradigm of Personalized Medicine / George M. Yousef, Nicole M. A. White, Andrew H. Girgis -- Pancreatic Cancer Genomics / Vincenzo Corbo, Andrea Mafficini, Eliana Amato, Aldo Scarpa -- Breast Cancer Genomics: From Portraits to Landscapes / Ulrich Pfeffer, Valentina Mirisola, Alessia Isabella Esposito -- Genomic Landscape of Ovarian Cancer / Delia Mezzanzanica, Loris De Cecco, Marina Bagnoli, Patrizia Pinciroli -- Genetics of Endometrial Carcinoma / M. Angeles López-García, Begoña Vieites, M. Angeles Castilla -- Usefulness of Molecular Biology in Follicular-Derived Thyroid Tumors: From Translational Research to Clinical Practice / Alexandre Bozec, Marius Ilie, Paul Hofman -- Sarcomas Genetics: From Point Mutation to Complex Karyotype, from Diagnosis to Therapies / Frédéric Chibon, Alain Aurias, Jean-Michel Coindre -- Novel Molecular Acquisitions in Leukemias / Sabina Chiaretti, Robin Foà -- Where Do We Stand in the Genomics of Lymphomas? / Francesco Bertoni, Zhi-Ming Li, Emanuele Zucca -- The Genomics of Multiple Myeloma and Its Relevance in the Molecular Classification and Risk Stratification of the Disease / Antonino Neri, Luca Agnelli -- Genome-Wide Analysis and Gene Expression Profiling of Neuroblastoma: What Contribution Did They Give to the Tumor Treatment? / Gian Paolo Tonini.

Genome-Wide Mapping Of RNA Pol-II Promoter Usage In Mouse Tissues By Chip-Seq -- Using Native Chromatin Immunoprecipitation To Interrogate Histone Variant Protein Deposition In Embryonic Stem Cells -- Reduced Representation Bisulfite Sequencing To Identify Global Alteration In The DNA Methylation -- A High-Throughput Microrna Expression Profiling System -- Using Pooled Mir30-Shrna Library For Cancer Lethal And Synthetic Lethal Screens -- Genome-Wide RNA Interference Screening To Identify Regulators Of Epigenetic Silencing Of A Tumor Suppressor Gene -- A Diphtheria Toxin Negative Selection In RNA Interference Screening -- Cancer Metabolism: Crosstalk Between Signaling And O-Glcnacylation -- Targeted Genome Modification Via Triple Helix Formation -- Synthesis Of Stabilized Alpha-Helical Peptides -- Arginine-Grafted Biodegradable Polymer: A Versatile Transfection Reagent For Both DNA And Sirna -- Using Laco Arrays To Monitor DNA Double-Strand Break Dynamics In Live Schizosaccharomyces Pombe Cells -- Zebrafish As A Platform To Study Tumor Progression -- Clonal Screens To Find Modifiers Of Partially Penetrant Phenotypes In C. Elegans -- Serum Profiling Using Protein Microarrays To Identify Disease Related Antigens -- Interrogation Of In Vivo Protein-Protein Interactions Using Transgenic Mouse Models And Stable Isotope Labeling -- New Biophysical Methods To Study The Membrane Activity Of Bcl-2 Proteins -- Purification Of Recombinant 2XMBP Tagged Human Proteins From Human Cells -- Computational Analysis In Cancer Exome Sequencing -- Matrix Factorization Methods For Integrative Cancer Genomics -- Computational Methods For DNA Copy-Number Analysis Of Tumors.

This is the second edition of a practice-oriented, well-illustrated manual on the microscopic grading of tumors. After an introduction on the history and basic tenets of tumor grading, subsequent chapters focus on specific organ systems. In each case, the most widely used system for grading common tumors is presented and discussed. Throughout, careful attention is paid to the principles of microscopic tumor grading, ancillary methods to improve grading, and the latest techniques used in evaluating tumors and formulating prognosis.

Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.

"This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging"--Publisher's description.

This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. ℗ℓ The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.

This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.

Specific Organ Tumors: General Considerations On Immunotherapy -- Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting -- Immunotherapy For Pediatric Solid Tumors -- Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma -- Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma -- Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies -- Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers -- Immunology And Immunotherapy Of Colorectal Cancer -- Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers -- Immunology And Immunotherapy Of Pancreatic Tumors -- Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma -- Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma -- Immunopathology And Immunotherapy Of Oral Cancers -- Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas -- Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors -- Immunology And Immunotherapy Of Pulmonary Tumors -- Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers -- Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer -- Immunology And Immunotherapy Of Ovarian Cancer -- Revisiting Immunology For Breast Cancer -- Immunology And Immunotherapy Of Graft Versus Host Disease.

This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for skin cancers, ocular malignancies, endocrine malignancies, cardiac cancers, vascular cancers, and HPV-associated cancers. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, CNS tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists. .

This book presents the clinical scope of cancer immunotherapeutic agents for solid tumors and Hematologic malignancies, elaborates on the scientific details of their modes of action, and presents the impact of these agents on oncology, patients and the broader healthcare system. At present, cancer immunotherapies fall broadly into three categories: immune checkpoint inhibitors (ICIs), adoptive T cell therapies, and cancer vaccines which have distinct mechanisms of action. Immune checkpoint inhibitors rely upon disrupting tumor antigen recognition as self by the immune system through inhibition of checkpoint molecules. Adoptive T cell therapies involve the engineering of T cells ex vivo to target and destroy tumor cells. The first part of this book will provide an overview of the discovery and mechanistic details of the technology. The second part will be devoted to elaborating on the clinical outcomes, successes and limitations for specific tumor subtypes, which includes both solid tumors and hematologic malignances for both pediatric and adult populations. As such, the book offers a valuable resource for oncologists, hematologists, and all those seeking an up-to-date overview of cancer immunotherapies.

This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.

This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.

This is the second edition of the only book to be devoted exclusively to the total cancer picture in adolescents and young adults (AYA), now expanded from the age range 15-29 to that of 15-39 years. For each of the diverse spectrum of cancers encountered in the AYA group, the epidemiology, natural progression, diagnostic approaches, and treatment options are described, with special emphasis on strategies for early detection and prevention. Comparison is made with management of both younger and older patients, and model programs are presented that address common diagnostic, staging, treatment, and psychosocial shortcomings in the AYA group. Detailed attention is also paid to principles and practices of care, with consideration of psychosocial and quality of life issues, social support systems, rehabilitation, late effects, insurance, and economic aspects of health care, among other topics. The authors make compelling arguments for integrated strategies that allow young adults to benefit from the combined expertise of pediatric and adult oncologists in systems that identify both the complex disease and the social issues specific to this population. The proposed models of care include relationships with other specialties that do not specifically target this age group, i.e., infectious disease, endocrinology, pulmonary medicine, nephrology, gastroenterology, thoracic and abdominal surgery, urology, otolaryngology, and neurosurgery. New patterns of communication are advocated and endorsed as essential for productive interaction involving these specialties. References are extensive and are oriented toward users in pediatric hematology-oncology medical oncology, radiation oncology, surgical oncology, gynecologic oncology, oncology nursing, psycho-oncology, social work, epidemiology, public health and health services research. The contributing authors are from the United States, the United Kingdom, Canada, Italy, France, Israel, Switzerland and Australia, Germany, Japan and the Netherlands. .

This book discusses the current state of cancer pathway as it is relevant to sub-Saharan Africa and highlights differences in epidemiology and the underlying problems with management. It outlines the current practice and opinions in all forms of cancer, also highlighting future prospects. Starting by providing background information on the epidemiology and genomic variations, the book then goes on to look at Infection-related cancers and continues to prostate GI, breast cancer and ovarian and cervical cancer. The last part of the book focuses on delivery of affordable and accessible care. Palliative services and primary and transnational research, as well as clinical trials are also discussed. Written by a team of authors based in the UK, Nigeria, South Africa and the US. this book offers an overview of the current state and challenges of cancer care in sub-Saharan Africa, and it would be valuable to policy makers, researchers, funding organisations, and can be an adjunct to standard text books for students, residents and established doctors.

This is an Open Access book. This book is a must-have for healthcare providers and researchers, public health specialists and policy makers who are interested and involved in cancer care in the Arab world. The Arab world consists of 22 countries, which are members of the Arab League and spanning over 13,132,327 km2 with over 423,000,000 population. Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine. Special topics of interest and unique to the Arab world are also discussed, such as out of the country's medical tourism for cancer care and cancer care during war and conflict. Other special chapters include: Cancer research in the Arab world, Radiation therapy in Arab World and Pediatric Oncology in the Arab World Cancer in the Arab World is the first comprehensive book that addresses cancer care in depth in all Arab countries and it is endorsed by the prestigious Emirates Oncology Society.

Principles of diagnosis and therapy in traditional Chinese medicine -- Herbs and prescriptions for therapy -- Cancer prevention and treatment using TCM -- Major forms of cancer and case studies -- Diet, exercise, and health cultivation.

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography - mass spectrometry, capillary electrophoresis - mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.

Chapter 1. Exosomes as theranostics for lung cancer -- Chapter 2. Nanotechnology approaches to improving cancer immunotherapy -- Chapter 3. Ultrasound contrast agents and delivery systems in cancer detection and therapy -- Chapter 4. Dendronized systems for the delivery of chemotherapeutics -- Chapter 5. Thermosensitive liposomes for image-guided drug delivery -- Chapter 6. Supramolecular analytical chemistry in cancer research -- Chapter 7. Gold nanoparticles for the delivery of cancer therapeutics -- Chapter 8. Single-cell proteomics for cancer immunotherapy.

Cancer nanotechnology : opportunities for prevention, diagnosis, and therapy / Reema Zeineldin and Joan Syoufjy -- Improved targeting of cancers with nanotherapeutics / Christian Foster, Andre Watson, Joseph Kaplinsky, and Nazila Kamaly -- Multifunctional liposomes / Bhawani Aryasomayajula, Giuseppina Salzano, and Vladimir P. Torchilin -- Multifunctional concentric FRET-quantum dot probes for tracking and imaging of proteolytic activity / Melissa Massey, Jia Jun Li, and W. Russ Algar -- Preparation and characterization of magnetic nano-in-microparticles for pulmonary delivery / Amber A. McBride, Dominique N. Price, and Pavan Muttil -- Multifunctionalization of gold nanoshells / Sandra W. Bishnoi and Yujen Lin -- Fabrication of photothermal stable gold nanosphere/mesoporous silica hybrid nanoparticle responsive to near-infrared light / Bei Cheng and Peisheng Xu -- Engineering well-characterized PEG-coated nanoparticles for elucidating biological barriers to drug delivery / Qi Yang and Samuel K. Lai -- Piloting your nanovehicle to overcome biological barriers / Steven M. Richards and Robert B. Campbell -- Detecting sonolysis of polyethylene glycol upon functionalizing carbon nanotubes / Ruhung Wang, Vasanth S. Murali, and Rockford Draper -- Methods for generation and detection of nonstationary vapor nanobubbles around plasmonic nanoparticles / Ekaterina Y. Lukianova-Hleb and Dmitri O. Lapotko -- Force measurements for cancer cells / Vivek Rajasekharan, Varun K.A. Sreenivasan, and Brenda Farrell -- Fractal analysis of cancer cell surface / Igor Sokolov and Maxim E. Dokukin -- Quantitative evaluation of the enhanced permeability and retention (EPR) effect / Luisa M. Russell, Charlene M. Dawidczyk, and Peter C. Searson -- Nanotechnology-based cancer vaccine / Aws Alshamsan -- Designing multicomponent nanosystems for rapid detection of circulating tumor cells / Shashwat S. Banerjee, Vrushali Khobragade, and Jayant Khandare -- Fluorescence and bioluminescence imaging of orthotopic brain tumors in mice / Emilie McKinnon, Alfred Moore, Suraj Dixit, Yun Zhu, and Ann-Marie Broome -- Ultrasensitive biosensing platform employing acetylcholinesterase and gold nanoparticles / Dingbin Liu and Xiaoyuan Chen -- Gene silencing using multifunctionalized gold nanoparticles for cancer therapy / Alexandra R. Fernandes and Pedro V. Baptista -- Generation of dose-response curves and improved IC50s for PARP inhibitor nanoformulations / Paige Baldwin, Shifalika Tangutoori, and Srinivas Sridhar -- Artificial antigen-presenting cells for immunotherapies / Alyssa L. Siefert, Tarek M. Fahmy, and Dongin Kim -- Exploiting uptake of nanoparticles by phagocytes for cancer treatment / Mee Rie Sheen and Steven Fiering -- Pulmonary delivery of magnetically targeted nano-in-microparticles / Amber A. McBride, Dominique N. Price, and Pavan Muttil -- Neutron-activatable nanoparticles for intraperitoneal radiation therapy / Derek Hargrove and Xiuling Lu -- Nanoparticle-mediated x-ray radiation enhancement for cancer therapy / Autumn D. Paro, Ilanchezhian Shanmugam, and Anne L. van de Ven -- Radiosensitizing silica nanoparticles encapsulating docetaxel for treatment of prostate cancer / Jodi Belz, Noelle Castilla-Ojo, Srinivas Sridhar, and Rajiv Kumar.

"This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted molecular therapies, immunotherapies, hematopoietic stem cell transplantation, and infections involving the nervous system. The final section focuses on the most important neurologic complications in cancers arising from specific organs. In addition to capturing the latest advancements in the rapidly evolving fields of oncology and cancer neurology, the goal of this resource is to lead clinicians toward prompt diagnosis and intervention in order to improve patient quality of life"--Publisher's description.

"Cancer Nursing: Principles and Practice, Eighth Edition continues as the gold standard in oncology nursing. With contributions from the foremost experts in the field, it has remained the definitive reference on the rapidly changing science and practice of oncology nursing for more than 25 years. Completely updated and revised to reflect the latest research and developments in the care of patients with cancer, the Eighth Edition includes new chapters on the biology of cancer, sleep disorders, and palliative care across the cancer continuum.The Eighth Edition also includes significant updates to the basic science chapters to reflect recent increases in scientific knowledge, especially relating to genes and cancer. Also heavily revised are the sections devoted to the dynamics of cancer prevention, detection, and diagnosis, as well as treatment, oncologic emergencies, end of life care, and professional and legal issues for oncology nurses. In addition, it provides extensive and current information on breast cancer, including two separate chapters on early stage breast cancer and metastatic breast cancer, and careful attention to survivorship issues." [Jones & Bartlett Learning].

Preface -- 1. Evidence-Based Medicine -- 2. Oral Cavity -- 3. Oropharynx -- 4. Nasopharynx -- 5. Hypopharynx -- 6. Larynx -- Index.

Part I: Principles of oncology. The cancer genome -- Hallmarks of cancer: an organizing principle for cancer medicine -- Molecular methods in cancer -- Part II: Etiology and epidemiology of cancer. Tobacco -- Oncogenic viruses -- Inflammation -- Chemical factors -- Physical factors -- Dietary factors -- Obesity and physical activity -- Section 2: Epidemiology of cancer. Epidemiologic methods -- Trends in United States cancer mortality -- Part III: Cancer therapeutics. Essentials of radiation therapy -- Cancer immunotherapy -- Pharmacokinetics and pharmacodynamics of anticancer drugs -- Pharmacogenomics -- Alkylating agents -- Platinum analogs -- Antimetabolites -- Topoisomerase interactive agents -- Antimicrotubule agents -- Kinase inhibitors as anticancer drugs -- Histone deacetylase inhibitors and demethylating agents -- Proteasome inhibitors -- Poly (ADP-ribose) polymerase inhibitors -- Miscellaneous chemotherapeutic agents -- Hormonal agents -- Antiangiogenesis agents -- Monoclonal antibodies -- Assessment of clinical response -- Part IV: Cancer prevention and screening. Tobacco use and the cancer patient -- Role of surgery in cancer prevention -- Cancer risk-reducing agents -- Cancer screening -- Genetic counseling -- Part V: Cancer of the skin. Cancer of the skin -- Molecular biology of cutaneous melanoma -- Cutaneous melanoma -- Genetic testing in skin cancer.

This book presents an up-to-date and thorough overview of cancer of unknown primary, encompassing topics ranging from epidemiology, tumor biology, and prognostic factors through to the most recent diagnostic and therapeutic advances. All aspects of management are covered, including radiological, nuclear medicine, and pathological diagnosis, site-specific therapies, platinum-based combination chemotherapy, radiotherapy, and novel targeted treatments. Clear guidance is offered on diagnosis of the tissue of origin by means of gene expression and micro-RNA analyses and its therapeutic implications. Detailed directions are also provided on the identification of subsets of patients with a more favorable prognosis, in whom specific treatment offers the chance of long-term survival or even cure. Readers will find Cancer of Unknown Primary to be an ideal source of practically oriented information that will assist in delivery of the best possible care for patients with this challenging diagnosis. .

Cancer remains a major challenge for medicine and it continues to claim lives and cause great suffering. Pain is a symptom experienced by most cancer patients regardless of disease stage, and less than 50% of cancer pain patients achieve effective pain and symptom control though available therapies. If these therapies are utilized correctly, many more patients can achieve effective control. While opioids are still seen as the mainstay of cancer pain treatment, it is necessary to examine whether this treatment strategy still holds true in the 21st century. Cancer Pain provides a comprehensive, up-to-date, practical guide to the management of pain in cancer patients. The book provides a clear, concise explanation of cancer pain syndromes, a modern understanding of the pathophysiological mechanism and an overview of recent developments in creating pre-clinical cancer pain models. It offers the reader the wide and improved options for management of cancer pain in clinical practice, including the use of opioid and non-opioid drugs, and defines the role of non-pharmacological methods for pain control. Cancer Pain also provides an overview of the latest developments in the management of cancer, which have major implications for the current and future thinking in cancer pain treatment strategy. This text is an invaluable resource for doctors, trainees and clinical nurse specialists in palliative medicine and oncology, and would be of interest to anyone who wishes to gain a better understanding of the complex nature of cancer pain and the tools available to alleviate it.

Microtubule inhibitors -- Alkylating agents -- Enzyme inhibitors : topoisomerase I inhibitors -- Enzyme inhibitors : topoisomerase II inhibitors -- Antimetabolites -- Monoclonal antibodies -- VEGF trap -- Tyrosine kinase inhibitors -- Anti-androgen therapies -- Mammalian target of rapamycin (MTOR) inhibitors -- Histone deacetylase (HDAC) inhibitors -- Hypomethylating agents -- Proteasome inhibitors -- Immunomodulatory agents -- L-asparaginase enzymes -- Promyelocytic leukemia gene retinoic acid receptor-alpha (PMI-RARA)translocation inhibitors -- Sipuleucel-T(Provenge®) -- Omacetaxine (Synribo®) -- Estramustine (Emcyt®).

Cancer Policy: Pharmaceutical Safety provides invaluable information on the interesting and compelling field of cancer drug safety. Identifying and understanding high-priority policy issues and key pharmacovigilance strategies is of paramount importance. In this volume, outstanding and original chapters provide an overview and synthesis of the latest thoughts and findings relating to drug safety in the cancer domain. Topics include natural language processing and pharmacovigilance of alternative cancer pharmaceuticals. The information presented in this volume will improve understanding of emerging strategies to identify adverse drug reactions and drug-drug interactions within the cancer setting and will highlight policies that have been instituted to improve cancer patient safety. In summary, Cancer Policy: Pharmaceutical Safety explores many of the important areas of pharmacovigilance research in oncology.

Combining computational and experimental methods for identifying molecular targets of phytochemicals / Ann M. Bode and Zigang Dong -- Common methods used for the discovery of natural anticancer compounds / Min Tang ... [et al.] -- Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals / Francisco Fuentes ... [et al.] -- Methods to analyze chemopreventive effect of silibinin on prostate cancer biomarkers protein expression / Gagan Deep, Swetha Inturi, and Rajesh Agarwal -- Approach to the evaluation of berries for cancer prevention with emphasis on esophageal cancer / Gary D. Stoner ... [et al.] -- Use of mouse models for lung cancer chemoprevention studies / Yian Wang ... [et al.] -- Azoxymethane plus dextran sulfate sodium-induced mouse colon cancer model for the study of dietary chemoprevention of inflammation-associated carcinogenesis / Ha-Na Lee, Hye-Won Yum, and Young-Joon Surh -- Use of seahorse extracellular flux analyzer in mechanistic studies of naturally occurring cancer chemopreventive agents / Michelle B. Moura ... [et al.] -- Utilizing RNA-seq to define phytochemical-induced alterations in insulin and IGF-regulated transcriptomes / Heather Beckwith and Douglas Yee -- Ex vivo use of keratinocytes from adult mice to define stem cell activities in cancer research / Rebecca J. Morris ... [et al.] -- Quantitation of acetaldehyde-DNA adducts : biomarkers of alcohol consumption / Silvia Balbo and Stephen S. Hecht -- Imaging tools in discovery and development of phytochemical chemopreventive agents / Marna Ericson -- Designing the chemoprevention trials of tomorrow : applying lessons learned from past definitive trials / Karen Colbert Maresso and Ernest Hawk.

Genetic testing and counseling for cancer have made great strides in recent years. The popular demand for advanced screening, advances in testing, and the response of insurance companies and corporations have all served to shape this important area of cancer risk management. This practical, user-friendly guidebook allows you to search by disease site for the hereditary cancer syndromes relevant to your patient's cancer. This handy resource will help you formulate questions when expanding that patient's personal and family history, identify the genes that are most relevant, determine whether to refer that patient for genetic counseling and testing, and guide the patient's long-term management based on the patient's mutation-positive or -negative status. The guidebook will be of equal value to the practicing oncologist, surgeon, urologist, endocrinologist, gynecologist, primary care physician, physician's assistant, advanced practice nurse, and any other clinician counseling a patient who has had cancer. Informative overview summarizes the history and current state of genetic cancer testing. Site-specific chapters help you locate essential facts quickly. Expert contributors share their years of experience in genetic testing and counseling. Timely insights address key medical, ethical, legal, and financial implications of genetic cancer testing.

This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field. Cancer Regional Therapy summarizes the history, current technology, common procedures, and future prospects in this field and includes procedures from many surgical and interventional radiologic disciplines.

Finally, a concise pocket guide designed as a quick reference for busy clinicians who seek to improve the care they provide to cancer patients and cancer survivors. It is a comprehensive text formatted for fast access to a wide range of clinical information. This compact compendium is conveniently organized by cancer type for rapid review. It describes the many issues that cancer patients may face throughout the chronologic spectrum of care, starting from cancer diagnosis, to treatment, and survivorship. Each chapter helpfully highlights common impairments and treatment options using succinct tables, helpful illustrations and clinical peals from experts in the field. In addition, each chapter contains a clinical case and questions on the material to enhance understanding. Evidence for exercise treatment, including pertinent exercise precautions, is included, as are innovative research topics and emerging treatments. This includes dedicated chapters covering cancers of the breast; digestive organs; brain, eye, and central nervous system; urinary tract and genital organs; lip, oral cavity, and pharynx; lymphoid, hematopoietic, and related tissues; bone, articular cartilage, and soft tissues; respiratory and intrathoracic organs; skin. Thankfully, advances in cancer care such as chemotherapy, radiation, and surgery mean that more people than ever before are surviving long after their cancer diagnosis. Unfortunately, a large fraction of them live with at least one serious impairment as a consequence of their treatments that seriously impacts their ability to function and quality of life. This concise and essential guide to cancer rehabilitation will help the clinician navigate the care of this often complex population.

Cancer-related fatigue (CrF) is increasingly recognized as a significant problem for patients with cancer at all stages, including those undergoing therapy and in remission. In fact, studies have shown that CrF causes patients more distress than pain, nausea, or vomiting and yet fatigue is still often undertreated and rarely studied. However, several new treatments such as are being investigated to determine the most effective ways to manage this debilitating symptom and improve patient quality of life. Cancer-Related Fatigue will provide a concise overview of this condition, with an evidence-based discussion of diagnosis, treatment, and long-term management.

1.Introduction: the need to conduct cancer research in developing countries -- 2.Steps of a research study: from research question to publication -- 3.Types of research designs -- 4.Clinical research in developing countries: An overview -- 5.The research protocol -- 6.Ethics of conducting cancer research in developing countries -- 7.Data management and statistics -- 8.Funding For Cancer Research and Clinical Studies in Low and Middle-Income Countries -- 9.International Collaboration in Cancer Research -- 10.Publication and dissemination of research findings.

In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.

This book provides a concise, yet comprehensive overview of cancer risks in patients with inflammatory bowel disease (IBD), as well as the screening modalities used to reduce these risks. Each chapter presents a major malignancy that patients with IBD are at risk from, stemming from the disease itself or from the medications used to treat the disease. Malignancies covered include colorectal cancer, skin cancer, lymphoma, and other cancers. Cancer risk and screening with current and emerging drug therapies are also discussed. Written by experts in the field, Cancer Screening in Inflammatory Bowel Disease: A Guide to Risk Management and Techniques is a valuable resource for gastroenterologists, colorectal surgeons, and primary care physicians who treat and manage patients with inflammatory bowel disease.

This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

Oxytocin and vasopressin systems: oxytocin, vasopressin, and their interplay with gonadal steroids: essentials of cancer stem cells and conceptual modeling -- Theoretical and experimental foundations of the "cancer stem cell" model -- The hallmarks of prostate cancer stem cells -- Self-renewal, induced proliferation, and autonomous cell growth represent distinct modes of cell multiplication: relevance to the cancer stem cell theory -- Human embryonic stem cells and cancer: modeling disease in a dish -- Cancer stem cell as a result of a reprogramming-like mechanism: implications in tumor development and treatment -- A cancer stem cell model: an insight into the conversion of induced pluripotent stem cells to cancer stem-like cells -- Altruistic stem cells and cancer stem cells -- The emerging concept of EMT-induced cancer stem cells -- Models to study chronic myeloid leukemia cancer stem cells -- Cancer stem cells in melanoma: biomarkers and mathematical models -- Stem cells in liquid tumors -- Acute myeloid leukemia stem cells: updates and controversies -- Leukemia-initiating cells in acute lymphoblastic leukemia -- Stem cells in solid tumors -- Lung cancer stem cells and resistance to radiotherapy -- Prostate cancer cell heterogeneity and prostate cancer stem cells -- Glioblastoma stem cells drive tumor recurrence and patient relapse: what's the evidence? -- Stem cells and pancreatic cancer -- Melanoma subpopulations with cancer stem cell phenotypes -- Sarcoma stem cells -- Cancer stem cells in tumor metastasis perspective -- Cancer stem cells in metastasis and minimal residual disease -- Role of cancer stem cells in metastasis -- Cancer stem cells and the stromal microenvironment -- A perspective on breast cancer malignant progression: from cancer stem cell intra tumor heterogeneity to metastasis-initiating cells -- Novel and potential targets in cancer stem cells -- Targeting cancer stem cells: modulating embryonic stem cell signaling, epigenetics, and tumor metabolism -- Oct4, Oct1, and cancer stem cells -- The role of Cripto-1 in cancer and cancer stem cells -- Leptin signaling in the regulation of stem and cancer stem cells -- Tumor-initiating stem-like cells: carcinogenesis through toll-like receptors, environmental factors, and virus -- The role of epithelial cell polarity pathways on cancer stem cells -- Cancer-initiating cells, exosomes, and the premetastatic niche -- Microrna therapeutics to target brain tumor stem cells -- The riboproteome orchestrates self-renewal and cell fate in leukemia -- Clinical relevance of cancer stem cells in patients -- Targeting different states of breast cancer stem cells -- Difficulties in targeting the beating heart: therapeutic implications of the cancer stem cell hypothesis in melanoma -- Targeting cancer stem cells for overcoming drug resistance and cancer progression -- The role of cancer stem cells in tumor radioresistance.

Evidence-based symptom management -- Artharalgias and myalgias -- Cancer-related fatigue -- Menopausal symptoms -- Pain -- Sleep disturbances -- Hypersensitivity reactions to antineoplastic drugs -- Infection -- Constipation -- Diarrhea -- Nausea and vomiting -- Malignant ascites -- Bladder disturbances -- Bleeding and thrombotic complications -- Dyspnea -- Effusions -- The cancer cachexia syndrome -- Dysphagia -- Mucositis -- Xerostomia -- Increased intracranial pressure -- Peripheral neuropathy -- Alopecia -- Altered body image and sexual health -- Extravasation -- Lymphedema -- Ocular and otic complications -- Skin and nail bed changes -- Anxiety -- Cognitive dysfunction -- Depression -- Grief -- Spiritual distress -- Symptoms when death is imminent.

A Time Travel Journey Through Cancer Therapies -- Nanotechnology for Cancer Treatment: Possibilities & Limitations -- Vascular Targeting Approaches to Treat Cancer -- Tumor Immunotherapy by Utilizing a Double-Edged Sword Chemokines -- Cancer Biology: Some Causes for a Variety of Different Diseases -- Cancer Stromal Targeting (CAST) Therapy and Tailored Antibody Drug Conjugate Therapy Depending on Nature of Tumor Stroma -- Cancer Cell Respiration: Hypoxia and pH in Solid Tumors -- Tumor Vasculature, EPR Effect, and Anticancer Nanomedicine: Connecting the Dots -- Pressure Gradients in Solid Tumors -- The ADAMs: New Therapeutic Targets for Cancer? -- Role of the Extracellular Matrix Enzyme Activities and Metastasis -- The Role of Non-Cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as Model to Understand the Impact of Tumor Microenvironment on Epithelial Carcinogenesis -- Heterogeneity of Cancers and its Implication for Targeted Drug Delivery -- A Study of Cancer Heterogeneity: From Genetic Instability to Epigenetic Diversity in Colorectal Cancer -- Nanotherapeutics in Multidrug Resistance -- Stem Cells and Cancer -- Mechanisms of Metastasis -- Cancer-Specific Ligand/Receptor Interactions -- Targeting Drugs to Cancer: A Tough Journey to the Tumor Cell -- Long Circulation and Tumor Accumulation -- Convective and Diffusive Transport in Drug Delivery -- Intravital Real-Time Confocal Laser Scanning Microscopy for the in Situ Evaluation of Nanocarriers -- The EPR effect in Cancer Therapy -- In Vitro 3-dimensional Cancer Culture Model -- Complex Transport Around Tumor: Need for Realistic In Vitro Tumor Transport Model -- The Missing Components Today and the New Treatments Tomorrow.

I: In vitro diagnostics. Cancer theranostics: an introduction -- Genomics-based cancer theranostics -- Proteomics-based theranostics -- II: Molecular imaging. Radionuclide imaging of cancer therapy -- Near-infrared fluorescence imaging probes for cancer diagnosis and treatment -- Bioluminescence imaging of cancer therapy -- Magnetic resonance imaging of cancer therapy -- Ultrasound imaging of cancer therapy -- Photoacoustic imaging for cancer diagnosis and therapy guidance -- III: Imaging-guided therapy. Multimodality image-guided lung intervention systems -- Label-free molecular vibrational imaging for cancer diagnosis -- Multimodality image-guided treatment -- Medical robotics for cellular and molecular imaging -- IV: Theranostic platforms. Porphyrins for imaging, photodynamic therapy, and photothermal therapy -- Magnetic resonance imaging and alternating magnetic fields -- Ultrasound for drug/gene delivery -- Radionuclides for imaging and therapy in oncology -- Noble metal nanoparticle platform -- Cancer theranostics with carbon-based nanoplatforms -- Silica nanoparticle platform -- Quantum dots for traceable therapeutic delivery -- Polymer- and protein-based nanotechnologies for cancer theranostics -- V: Other. Clinical translation and regulations of theranostics -- Scale-up production of theranostic nanoparticles -- Market considerations for nanomedicines and theranostic nanomedicines -- Application of theranostics to measure and treat cell heterogeneity in cancer.

Section I. Clinical -- Section II. Laboratory models -- Section III. Strategies to protect the ovary.

New approaches in immunotherapy for the treatment of lung cancer -- Novel approaches for vaccination against HPV-induced cancers -- Tapping the potential of DNA delivery with electroporation for cancer immunotherapy -- Targeted immunotherapy designed to treat MUC1-expressing solid tumour -- Chimeric DNA vaccines: an effective way to overcome immune tolerance -- Linked CD4 T cell help: broadening immune attack against cancer by vaccination -- mRNA cancer vaccines, messages that prevail -- The use of Anti-CD40 mAb in cancer -- Index.

Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules -- Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine -- Pulsing Dendritic Cells with Whole Tumor Cell Lysates -- Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy -- Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens -- Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma -- Dendritic Cells Primed with Protein-Protein Fusion Adjuvant -- Antigen-Specific mRNA Transfection of Autologous Dendritic Cells -- Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material -- Dendritic Cells Transfected with Adenoviral Vectors as Vaccines -- Genetic Modification of Dendritic Cells with RNAi -- Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy -- Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation -- Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines -- Modification of T Lymphocytes to Express Tumor Antigens -- Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor -- Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors -- Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients -- Cytokine Activation of Natural Killer Cells -- Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation -- Autologous Tumor Cells Engineered to Express Bacterial Antigens -- Tumor Cell Transformation Using Antisense Oligonucleotide -- The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy -- Cloning Variable Region Genes of Clonal Lymphoma Immunoglobulin for Generating Patient-Specific Idiotype DNA Vaccine -- Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography -- Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu -- TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens -- Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens -- Preparation of Polypeptides Comprising Multiple TAA Peptides -- Idiotype Vaccine Production Using Hybridoma Technology -- Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously-Expressed Antigens -- Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule -- Bacterial Vectors for the Delivery of Tumor Antigens -- Preparation of Peptide Microspheres Using Tumor Antigen-Derived Peptides -- Production of Antigen-Loaded Biodegradable Nanoparticles and Uptake by Dendritic Cells -- Development of Plasmid-Lipid Complexes for Direct Intratumoral Injection -- The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy -- Advances in Host and Vector Development for the Production of Plasmid DNA Vaccines -- Challenges Facing the Development of Cancer Vaccines -- Future of Cancer Vaccines.

Recounts the author's experience as a cancer patient. He was diagnosed with stage 2A Hodgkin lymphoma at age 30, and was cancer free in 2010, and five years later considered in complete remission.

Molecular biology of cancer and aging -- Caring for geriatric cancer patients : the concept of pawspice and what is needed aside from medical care -- The warning signs of cancer in geriatric pets -- Basic types of cancer and their biological behavior -- Generating the diagnosis and prognosis of cancer in geriatric pets -- Treating cancer in geriatric pets -- Principles and philosophic perspective -- The role of surgery in cancer management -- Chemotherapy in the management of geriatric cancer -- Adverse effects of cancer therapy in geriatric pets -- The role of radiation therapy in cancer management -- Immunotherapy, cancer vaccines, and gene therapy -- Chemoprevention and immunonutrition -- Integrative and alternative medicine -- Electroporation and electrochemotherapy -- Pain control for the geriatric cancer patient -- Decision making with advanced and recurrent cancer in the geriatric patient -- When and how to decide that a geriatric cancer patient is terminal -- Palliative care : end of life 'pawspice' care -- Euthanasia for the geriatric cancer patient -- The veterinary professional/client relationship : supporting your clients supporting yourselves -- Professional support : the wellbeing of the veterinarian and the team.

Basic principles in the diagnosis and management of small animal infection -- Laboratory diagnosis of canine and feline infectious diseases -- Isolation in cell culture -- Immunoassays -- Isolation and identification of aerobic and anaerobic bacteria -- Isolation and identification of fungi -- Nucleic acid detection assays -- Antiinfective therapy -- Principles of antiinfective therapy -- Antiviral and immunomodulatory drugs -- Antibacterial drugs -- Antifungal drugs -- Antiprotozoal drugs -- Basic principles for infection control -- Infection control programs for dogs and cats -- Immunization -- Major infectious diseases and their etiologic agents -- Viral diseases -- Rabies -- Canine parvovirus infections and other viral enteritides -- Canine distemper virus infection -- Canine herpesvirus infection -- Canine viral respiratory infections -- Infectious canine hepatitis -- Feline panleukopenia virus infection and other viral enteritides -- Feline coronavirus infection -- Feline immunodeficiency virus infection -- Feline leukemia virus infection -- Feline respiratory viral infections -- Feline poxvirus infections -- Pseudorabies -- Viral papillomatosis -- Vector-borne and other viral encephalitides -- Bacterial diseases -- Ehrlichiosis -- Anaplasmosis -- Rocky mountain spotted fever -- Salmon poisoning disease -- Coxiellosis and q fever -- Chlamydial infections -- Streptococcal and enterococcal infections -- Staphylococcus infections -- Gram-negative bacterial infections -- Anaerobic bacterial infections -- Bordetellosis -- Cell wall-deficient bacterial infections -- Mycoplasma infections -- Hemoplasma infections -- Actinomycosis -- Nocardiosis -- Mycobacterial infections -- Salmonellosis -- Enteric Escherichia coli infections -- Campylobacteriosis -- Enteric clostridial infections -- Gastric Helicobacter-like infections -- Leptospirosis -- Lyme borreliosis -- Bartonellosis -- Canine brucellosis -- Tetanus and botulism -- Yersinia pestis (plague) and other yersinioses -- Tularemia -- Bite and scratch wound infections -- Fungal and algal diseases -- Dermatophytosis -- Malassezia infections -- Blastomycosis -- Histoplasmosis -- Cryptococcosis -- Coccidioidomycosis -- Sporotrichosis -- Aspergillosis -- Rhinosporidiosis -- Candidiasis -- Miscellaneous fungal diseases -- Pythiosis, lagenidiosis, and zygomycosis -- Protothecosis -- Pneumocystosis -- Protozoal diseases -- Toxoplasmosis -- Neosporosis -- Leishmaniosis -- Babesiosis -- Cytauxzoonosis -- Canine and feline hepatozoonosis -- Trypanosomiasis -- Giardiasis -- Trichomoniasis -- Cryptosporidiosis -- Isosporiasis -- Miscellaneous protozoal diseases -- Infections of selected organ systems -- Pyoderma, otitis externa, and otitis media -- Osteomyelitis, discospondylitis, and infectious arthritis -- Infections of the cardiovascular system -- Bacterial bronchopneumonia and pyothorax -- Intra-abdominal infections -- Bacterial infections of the genitourinary tract -- Bacterial meningitis -- Vaccination schedules for dogs and cats.

This book discusses canine and feline skin cytology and the importance of this diagnostic tool in interpreting skin lesions. With more than 600 clinical and cytological color pictures, it explains the cytological patterns observed in all cutaneous inflammatory and neoplastic lesions in cats and dogs, as well as cutaneous metastasis of non-primary skin neoplasms. The first part of the book describes cell morphology and cytological patterns, providing an overview of the normal structure of the skin. In the second chapter, readers learn how to choose the best techniques for different types of lesions. Further chapters present the cytological findings in the main inflammatory and neoplastic skin diseases. By focusing on the macroscopic aspects of the lesions from which the cells are collected, it helps readers to interpret cytological specimens. The final chapter explores the cytology of cutaneous metastasis from internal organs or accessory glands. This book offers veterinary students and practitioners alike an essential diagnostic tool.

Looking ahead after 50 years of research on cannabinoids / Raphael Mechoulam -- Cannabinoid receptor intracellular signaling : the long journey from binding sites to biological effects / Lawrence C. Blume, Khalil M. Eldeeb, and Allyn C. Howlett -- Endocannabinoid biochemistry : what do we know after 50 years? / Filomena Fezza and Mauro Maccarrone -- Genetic dissection of the endocannabinoid system and how it changed our knowledge of cannabinoid pharmacology and mammalian physiology / Beat Lutz -- Cannabinoids, endocannabinoids, and stress / Cecilia J. Hillard, Qing-song Liu, XiaoQian Liu, Bin Pan, Christopher J. Roberts, and Leyu Shi -- Cannabinoids and the brain : new hopes for new therapies / Javier Fernández-Ruiz, Mariluz Hernández, and Yolanda García-Movellán -- Potential therapeutic applications of cannabinoids in gastrointestinal and liver diseases : focus on tetrahydrocannabinol pharmacology / Paolo Caraceni, Francesca Borrelli, Ferdinando A. Giannone, and Angelo A. Izzo -- Years of cannabinoid research and the need for a new nomenclature / Vincenzo Di Marzo and Luciano De Petrocellis.

This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol (Δ9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

This book presents a well-balanced view of the potential medical use of cannabinoids in pain. It comprehensively covers the current challenges with medical cannabis utilization and provides recommendations for research and future directions. Organized into nine sections, the book begins with an introduction to medical cannabis, including its history, regulations, and the general attitudes of pain physicians on cannabis. Section two explores the biological effects of marijuana via the endocannabinoid system and its complex structure of receptors and enzymes. Sections three, four, and five then delve further into pharmacology and the mechanisms of action applicable to cannabinoids in managing pain. Timely and socially conscious, section six examines the benefits of substituting opioids with cannabinoids for preoperative management. Echoing the book's well-rounded content, sections seven and eight consider the challenges with medical cannabis, including safety and quality control, brain development risks, vaping hazards, and withdrawal. The book then closes with a look at the future of cannabis in medical research. Thoroughly and equitably composed, Cannabinoids and Pain is an invaluable resource for primary care physicians, pain and palliative care physicians, and oncologists.

Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.

Contributors -- Preface -- Mouse Neuroblastoma CB1 Cannabinoid Receptor-Stimulated [35S]GTPgammaS Binding: Total and Antibody-Targeted Galpha Protein-Specific Scintillation Proximity Asays / by Khalil Eldeeb, Sandra Leone-Kabler, Allyn C. Howlett -- Protocols and Good Operating Practices in the Study of Cannabinoid Receptors / by Linda M. Console-Bram, Pingwei Zhao, Mary E. Abood -- Real-Time Measurement of Cannabinoid Receptor-Mediated cAMP Signaling / by Morag R. Hunter, David B. Finlay, Christa E. Macdonald, Erin E. Cawston, Natasha L. Grimsey, Michelle Glass -- Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain / by Luigia Cristino, Roberta Imperatore, Vincenzo Di Marzo -- Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2 / by Cecilia J. Hillard, Huan Huang, Caleb D. Vogt, Beatriz E. Rodrigues, Terrence S. Neumann, Daniel S. Sem, Friedhelm Schroeder, Christopher W. Cunningham -- Lipidomics: A Corrective Lens for Enzyme Myopia / by Heather B. Bradshaw, Emma Leishman -- Functional Analysis of Mitochondrial CB1 Cannabinoid Receptors (mtCB1) in the Brain / by Su Melser, Antonio C. Pagano Zottola, Roman Serrat, Nagore Puente, Pedro Grandes, Giovanni Marsicano, Etienne Hebert-Chatelain -- Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies / by Javier Fernández-Ruiz, María Gómez-Ruiz, Concepción García, Mariluz Hernández, José A. Ramos -- Metabolic Profiling of CB1 Neutral Antagonists / by Herbert H. Seltzman, Rangan Maitra, Katharine Bortoff, Jay Henson, Patricia H. Reggio, Daniel Wesley, Joseph Tam -- Ligand-Assisted Protein Structure (LAPS): An Experimental Paradigm for Characterizing Cannabinoid-Receptor Ligand-Binding Domains / by David R. Janero, Anisha Korde, Alexandros Makriyannis -- New Methods for the Synthesis of Cannabidiol Derivatives / by Ana Lago-Fernandez, Vanessa Redondo, Laura Hernandez-Folgado, Laura Figuerola-Asencio, Nadine Jagerovic -- Approaches to Assess Biased Signaling at the CB1R Receptor / by Robert B. Laprairie, Edward L. Stahl, Laura M. Bohn -- Design and Synthesis of Cannabinoid 1 Receptor (CB1R) Allosteric Modulators: Drug Discovery Applications / by Abhijit R. Kulkarni, Sumanta Garai, David R. Janero, Ganesh A. Thakur -- Assessing Allosteric Modulation of CB1 at the Receptor and Cellular Levels / by Caitlin E. Scott, Debra A. Kendall -- Purification of Functional CB1 and Analysis by Site-Directed Fluorescence Labeling Methods / by Jonathan F. Fay, David L. Farrens -- Mass Spectrometry Analysis of Human CB2 Cannabinoid Receptor and Its Associated Proteins / by Zhao-Hui Song, Alyssa S. Laun, Jian Cai -- Expression and NMR Structural Studies of Isotopically Labeled Cannabinoid Receptor Type II / by Alexei Yeliseev, Klaus Gawrisch -- Methods for the Development of In Silico GPCR Models / by Paula Morales, Dow P. Hurst, Patricia H. Reggio -- Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction / by Diane L. Lynch, Dow P. Hurst, Derek M. Shore, Mike C. Pitman, Patricia H. Reggio -- Author Index -- Subject Index.

Offers a guide addressing nursing skills and responsibilities in cannabis care, including the physiology of the human endocannabinoid system, cannabis care as it relates to specific disease processes, the history of cannabis, advocacy and ethics, and the ins and outs of cannabis dosing, delivery methods, side effects, and more. Essential for all practice areas, this is a foundational resource for both students and practicing nurses who want to provide knowledgeable and effective medical cannabis care. --From publisher description.

The use of cannabinoid-based medicines (CBM), and cannabis in particular, has risen steadily among cancer and palliative care patients over the last few years. This textbook aims to address the multiple challenges facing healthcare providers regarding the use of CBM in this vulnerable patient population. It provides insight into the latest preclinical and clinical data and offers a practical approach on the use of CBM in a rapidly evolving landscape. It answers questions regarding the prescribing process and elucidates controversies regarding cannabis disease-modifying effects. The first chapters will review basic concepts of the endocannabinoid system and pharmacology of CBM, while focusing more specifically on the unique characteristics of two main cannabinoids: THC and CBD. Indicating which benefits can be expected from using either or both of these compounds, the book then addresses issues of drug-drug interactions and other challenges involved in prescribing CBM to frail patients with polypharmacy and multiple comorbidities. Comparing available products, both approved and non-approved by the FDA, the book discusses regional challenges for accessing reliably tested and labelled products in the context of standardization efforts. After carefully determining objectives and addressing patient expectations, further chapters will examine the different clinical settings in which CBM may be useful in cancer care and explore symptom management, including cancer pain, anxiety, nausea, and insomnia among others. The possible benefits of cannabis psychoactivity will also be discussed, including harm reduction strategies for patients who wish to explore these effects. Cannabis and Cannabinoid-Based Medicines in Cancer Care: A Comprehensive Guide to Medical Management serves as a comprehensive text for oncologists, palliative care specialists, general practitioners, and nurse practitioners working with cancer patients or in palliative care settings.

Legalization of marijuana is becoming increasingly prominent in the United States and around the world. While there is some discussion of the relationship between marijuana and overall health, a comprehensive resource that outlines the medical literature for several organ systems, as well as non-medical societal effects, has yet to be seen. While all physicians strive to practice evidence-based medicine, many clinicians aren't aware of the facts surrounding cannabis and are guided by public opinion. This first of its kind book is a comprehensive compilation of multiple facets of cannabis recommendation, use and effects from a variety of different perspectives. Comprised of chapters dedicated to separate fields of medicine, this evidence-based guide outlines the current data, or lack thereof, as well as the need for further study. The book begins with a general overview of the neurobiology and pharmacology of THC and hemp. It then delves into various medical concerns that plague specific disciplines of medicine such as psychiatry, cardiology, gastrointestinal and neurology, among others. The end of the book focuses on non-medical concerns such as public health and safety, driving impairment and legal implications. Comprised of case studies and meta-analyses, Cannabinoids in Medicine: An Evidence-Based Approach provides clinicians with with a concise, evidence-based guide to various health concerns related to the use of marijuana. By addressing non-medical concerns, this book is also a useful resource for professionals working in the public health and legal fields.

This book educates and familiarizes psychiatrists with the impact of cannabis beyond the scope of addiction and ways to effectively discuss the existing literature and knowledge with patients. Cannabis in Psychiatric Practice is organized by clinical setting to help tailor the literature to psychiatrists and other mental health clinicians working in all areas, whether traditional outpatient clinics, emergency departments, inpatient psychiatry or medical units. It helps readers, regardless of their training background, learn about the impact of cannabis on a variety of disorders in a manner adjusted to the unique needs and challenges of their particular treatment settings and patient populations. The book also includes clinical cases and practical tips integrating the current evidence, treatment approaches, and psychoeducation needed to effectively practice in the era of modern-day psychiatry and cannabis legalization. Chapters are written in a clear, easy-to-read style, allowing readers to reference specific portions of the book as needed, increasing its utility for the general psychiatrist and mental health clinician. With the increasing prevalence and availability of cannabis and CBD products, this book is an invaluable reference for psychiatrists who wish to explore the impact of cannabis in their clinical practice.

This book examines the effectiveness of a unique area of patient care, cannabis use in medicine. While many American states have legalized medical marijuana, the FDA still has not approved it as a treatment due to a lack of studies to prove its validity.Countries such as Canada and Uruguay, on the other hand, have legalized cannabis. This book aids in accelerating the medical legitimacy of cannabis through comprehensive coverage of its uses, legality, pharmacology, and potential issues. Organized into three parts, the book begins with topics that function as an introduction to cannabis for medical use, such as patient assessments, the role of genetics, evidence-based therapy reviews, legal aspects, and pharmacology. Subsequent chapters then delve into the practical applications of medical cannabis use, including treatment for gastrointestinal disorders, neurological diseases, rheumatic diseases, and pain management. The book's final section features crucial discussions on the potential complications and adverse events in cannabis use, as well as occupation and pediatric considerations. Nuanced and timely, Cannabis Use in Medicine, is a vital resource for medical practitioners of all specialties looking to add cannabis to their repertoire of therapies.

Recent advances in capillary electrophoresis-based proteomic techniques for biomarker discovery / Chenchen Wang, Xueping Fang, and Cheng S. Lee -- Capillary electrophoresis-mass spectrometry of carbohydrates / Joseph Zaia -- Approaches to enhancing the sensitivity of carbohydrate separations in capillary electrophoresis / M.C. Breadmore -- Determination of monosaccharides derivatized with 2-aminobenzoic acid by capillary electrophoresis / Mitsuru Abo, Li-ping He, Kae Sato and Akira Okubo -- Determination of mono-, di-, and oligosaccharides by capillary electrophoresis with capacitively coupled contactless conductivity detection / Claudimir Lucio do Lago, Thiago Nogueira, Lucas Blanes and Renata Mayumi Saito -- Separation of chitooligosaccharides in acidic solution by capillary electrophoresis / Toshiaki Hattori, Nobuhiro Anraku, and Ryo Kato -- Capillary electrophoresis for the analysis of glycosaminoglycan-derived disaccharides / Yuqing Chang, Bo Yang, Amanda Weyers and Robert J. Linhardt -- High-throughput capillary electrophoresis-mass spectrometry : from analysis of amino acids to analysis of protein complexes / Mehdi Moini -- Separation of amino acids by capillary electrophoresis with light-emitting diode-induced fluorescence in the presence of electroosmotic flow / Ming-Mu Hsieh and Po-Ling Chang -- Quantification of arginine and dimethylated arginines in human plasma by field-amplified sample injection capillary electrophoresis UV detection / Angelo Zinellu, Salvatore Sotgia, Luca Deianna and Ciriaco Carru -- Capillary electrophoresis-mass spectrometry for peptide analysis : target-based approaches and proteomics/peptidomics strategies / Carolina Simó, Alejandro Cifuentes, and Václav Kašička -- High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS / Amaya Albalat, Vasiliki Bitsika, Petra Zurbig, Justyna Siwy and William Mullen -- Contribution of CE to the analysis of protein or peptide biomarkers / Kiarach Mesbah, Romain Verpillot, Franc̦ois de l'Escaille, Jean Bernard Falmagne and Myriam Taverna -- Highly charged polyelectrolyte coatings to prevent adsorption during protein and peptide analysis in capillary electrophoresis / Reine Nehmé and Catherine Perrin -- Capillary electrophoresis with laser-induced fluorescence detection of proteins from two types of complex sample matrices : food and biological fluids / Raul Garrido-Medina, Angel Puerta, Cristina Pelaez-Lorenzo, Zuly Rivera-Monroy, Andras Guttman, Jose Carlos Diez-Masa and Mercedes de Frutos -- Automated capillary electrophoresis in the screening for hemoglobinopathies / Frédéric Cotton, Fleur Wolff, and Béatrice Gulbis -- Protein fingerprinting of Staphylococcus aureus by capillary electrophoresis with on-capillary derivatization and laser-induced fluorescence detection / Cristina Pelaez-Lorenzo, Maria Teresa Veledo, Ramon Gonzales, Mercedes de Frutos and Jose Carlos Diez-Masa -- Capillary electrophoresis of seed storage proteins : the separation and identification of microheterogeneous rice glutelin subunits / Tomoyuki Katsube-Tanaka -- Evaluating amyloid beta (A[beta]) 1-40 degradation by capillary electrophoresis / Benjamin J. Alper and Walter K. Schmidt -- Capillary electrophoresis for protein profiling of the dimorphic, pathogenic fungus, penicillium marneffei / Julie M. Chandler, Heather R. Trenary, Gary R. Walker and Chester R. Cooper -- Capillary electrophoretic enzyme assays / Gerhard K.E. Scriba, Hans Abromeit, Martina Hense and Yi Fan -- A methodology for detection and quantification of esterase activity / Ana L. Simplício, Ana S. Coroadinha, John F. Gilmer and Joana Lamego -- Enzyme inhibitor screening by CE with and on-column immobilized enzyme microreactor created by an ionic binding technique / Chao Liu, Qianqian Zhang, and Jingwu Kang -- Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis / Philip M. Yangyuoru, Latanya Hammonds-Odie and Simon M. Mwongela -- Assessment of DNA damage by micellar electrokinetic chromatography / Paolo Fattorini, Giorgio Marrubini, Pierangela Grignani, Solange Sorc̦aburu-Cigliero and Carlo Previderé.

Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA?s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV. CAPRISA?s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA?s research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials? their creation, conduct and impact.

This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors, and gastrointestinal, dermatologic, and urologic disorders. It discusses the basic functions of the capsaicin receptor (TRPV1), its mechanisms of action, and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material on the subject that will stimulate future research.

This book contains complete information on Capsicum genetic resources, diversity, evolution, history and advances in capsicum improvement from classical breeding to whole genome sequencing, genomics, databases and its impact on next generation pepper breeding. Capsicum is one of the most important Solanaceae crops grown worldwide as vegetables and spices. Due to its high economic value and to meet the demands of enormous population growth amid biotic and abiotic stresses, there has been an ongoing breeding program utilizing available genetic resources with desired traits to increase the sustainable productivity of this crop for several decades. However, the precision breeding of this crop for desired traits only started with the advent of molecular markers. The recent advances in high-throughput genome sequencing technologies helped in the quick decoding of transcriptome, epigenome, nuclear and organeller genomes, thereby enhancing our understanding of the structure and function of the Capsicum genome, and helping in genomics assisted breeding. These advanced technologies coupled with conventional mapping have greatly contributed towards dissection and manipulation of economically important traits more precisely and made less time consuming.

This volume provides a comprehensive introduction and review of small bowel capsule endoscopy (SBCE). The book reviews the data regarding appropriate indications and contraindications for the implementation of small bowel capsule endoscopy, while discussing in detail the evolving role of SBCE in the treatment of obscure gastrointestinal bleeding, and the management of inflammatory bowel disease, small bowel polyposis syndromes, and refractory malabsorption. Topics such as complications of SBCE, methods to perform SBCE on patients with dysphagia or gastric emptying pathology, and understanding the normal anatomy of the gastrointestinal tract when viewed via SBCE are also discussed. In addition, an introduction to colon capsule technology and the next generation of small bowel capsule imaging is reviewed. The text is complemented by several illustrative cases that are demonstrated with both online full length videos as well as an online interactive companion that includes review questions to reinforce concepts learned in the text. Written by experts in the field, Capsule Endoscopy: A Guide to Becoming an Efficient and Effective Reader is an invaluable resource for novice capsule endoscopy readers, fellows in gastroenterology and hepatology, researchers, mid-level providers, residents, and medical students with an interest in learning how to implement and perform SBCE in the investigation of small bowel diseases.

Carbohydrate-based vaccines : an overview / Julia Hütter and Bernd Lepenies -- Glycans as vaccine antigens and adjuvants : immunological considerations / Stephanie Zimmermann and Bernd Lepenies -- Glycan array platform as a tool to identify carbohydrate antigens / Li Xia and Jeffrey C. Gildersleeve -- Antibody-carbohydrate recognition from docked ensembles using the AutoMap procedure / Tamir Dingjan, Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev -- Generation of monoclonal antibodies against defined oligosaccharide antigens / Felix Broecker, Chakkumkal Anish, and Peter H. Seeberger -- Murine whole-blood opsonophagocytosis assay to evaluate protection by antibodies raised against encapsulated extracellular bacteria / Guillaume Goyette-Desjardins, René Roy, and Mariela Segura -- Determination of N-linked glycosylation in viral glycoproteins by negative ion mass spectrometry and ion mobility / David Bitto, David J. Harvey, Steinar Halldorsson, Katie J. Doores, Laura K. Pritchard, Juha T. Huiskonen, Thomas A. Bowden, and Max Crispin -- N-glycosylation fingerprinting of viral glycoproteins by xCGE-LIF / René Hennig, Erdmann Rapp, Robert Kottler, Samanta Cajic, Matthias Borowiak, and Udo Reichl -- Temporary conversion of protein amino groups to azides : a synthetic strategy for glycoconjugate vaccines / Tomasz Lipinski and David R. Bundle -- Gold nanoparticles as carriers for synthetic glycoconjugate vaccines / Fabrizio Chiodo and Marco Marradi -- Identification and characterization of carbohydrate-based adjuvants / Timo Johannssen and Bernd Lepenies -- Characterization of carbohydrate vaccines by NMR spectroscopy / Francesco Berti and Neil Ravenscroft -- Characterization of capsular polysaccharides and their glycoconjugates by hydrodynamic methods / Stephen E. Harding, Ali Saber Abdelhameed, Richard B. Gillis, Gordon A. Morris, and Gary G. Adams -- Glycoconjugate vaccines : the regulatory framework / Christopher Jones.

This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

Carbon Sequestration in Agricultural Ecosystems addresses basic processes of soil C dynamics and explains the underlying controls of technical and economic potential of soil C sequestration. It contains discussions on soil inorganic and organic C, and the factors affecting their stock and fluxes. After an introduction on agricultural land uses and their effects on the global C cycle; processes, factors and causes influencing SIC and SOC dynamics are presented in detail based on up-to-date scientific knowledge. Also discussed are processes affecting dynamics of SIC and SOC sequestration in soils of croplands and grasslands, and how agricultural practices affect them. This is followed by a description of SOC sequestration in wetlands under agricultural use, and those under agroforestry systems. Then, how the increasing biomass production for bioenergy and biofuel affects the SOC stocks of agroecosystems is presented. This is followed by a critical discussion on the importance of biochar to soil C sequestration in agroecosystems. The book concludes with an outlook about the importance of soils of agroecosystems for climate change policy. Focus of the book is on scientific understanding of SIC and SOC sequestration in agroecosystems. It lists a set of questions at the end of each chapter to stimulate thinking and promote academic dialogue. Each chapter lists pertinent references on the current research, and summarizes the present understanding while identifying the knowledge gaps for future research. It is timely because of the growing interests by the policy makers (as documented by the "4 per Thousand" initiative at COP21 in Paris, and the "Adapting African Agriculture" program at COP22 in Marrakech) in making soils and agriculture important to solutions of addressing the global issues. The book is a valuable source of information intended for use by graduate and undergraduate students, scientists, land managers, private sector, policy makers and the general public.

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification.

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.

1. Preface -- Chemical carcinogenesis in mice as a model of human cancer: Pros and cons, Lorenzo Galluzzi -- 2. MPA/DMBA-driven mammary carcinomas, Aitziber Buqué Martinez -- 3. Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis in mice, Isabelle Plante -- 4. Urethane-induced lung carcinogenesis, Silvano Sozzani -- 5. Methylcholanthrene-induced fibrosarcomas, Awen Gallimore -- 6. BBN-driven bladder carcinomas -- Janos Terzic -- 7. Oral squamous cell carcinomas driven by 4NQO, Nancy J. Philp -- 8. Analysing skin tumor development in mice by the DMBA/TPA model, Cord Brakebusch -- 9. DSS/AOM-driven colorectal carcinomas, David C. Montrose -- 10. Diethylnitrosamine-induced liver tumorigenesis in mice, Peter Hasselblatt -- 11. Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice, Alison K. Bauer -- 12. Lung carcinomas induced by NNK and LPS, Peter Di -- 13. Pristane-induced mammary carcinomas, Bae Hoon Lee -- 14. The 4-NQO mouse model: an update on a well-established in vivo model of oral carcinogenesis, Pierre Saintigny.

Carcinomas of the larynx and hypopharynx present unique challenges when it comes to their assessment and management. Management involves the essential dilemma of optimizing cure rates while also ensuring that potential disability due to compromised airway, voice and swallowing is minimized. Treatment decisions involve careful disease assessment, judicious multispecialty decision-making, and subsequent meticulous implementation of the selected treatment modalities.The critical nature of each of these steps has led to dramatic advances in assessment techniques (radiology, endoscopy and photography, stroboscopy, narrow band imaging, contact endoscopy) and also in treatment methods (radiation therapy, combined concurrent chemo-radiation, combined sequential chemo-radiation, trans-oral CO2 laser and robotic surgery, partial laryngectomy, total laryngectomy, extended total laryngectomy). As such, treatment decisions have become increasingly complex with the twin objectives of maximizing cure as well as function preservation and are based on tumor stage, tumor location, systemic co-morbidities, nutritional status, patient priorities, and social and economic factors.    This multidisciplinary book has been written by a team of editors with considerable experience and expertise in these critical areas and a deep understanding of teamwork and the strengths and limitations of individual technologies and treatments. It presents a homogeneous and unbiased view that is applicable to all specialties involved in the care of larynx and hypopharynx cancers.

The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging. The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations. The third section of this volume highlights the roles of sympathetic nervous system with respect to [alpha]-adrenoceptor and [beta]-adrenoceptor mechanisms in the development of cardiac hypertrophy. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.

This concise book meets the market need for an accessible and up-to-date guide on understanding and managing cardiac anesthesia patients. It reflects the continual evolution of the very complex field of cardiac anesthesia. Organized into 10 sections, beginning chapters comprehensively examine the foundational concepts of cardiovascular function. The book then functions as a practical guide for clinical settings, including patient evaluation, operating room and anesthetic management, and postoperative care. Each chapter is authored by experienced cardiac anesthesiologists and many are supplemented by high quality, images, videos and tables. Written for the student, trainee, and junior cardiac anesthesiologist, Cardiac Anesthesia: The Basics of Evaluation and Management covers the core concepts needed to treat the cardiac surgery patient and to the skillset needed to succeed in this field.

This book provides a practical approach to cardiac perioperative care. The step-by-step format guides readers from basic concepts, such as cardiac physiology and pharmacology, to anesthetic management of specific cardiac surgical procedures, including cardiac percutaneous interventions, management of specific cardiac disease, circulatory support, and organ protection strategies. Written by experienced cardiac anesthesiologists in Europe, USA, Canada and Australia, this book provides an international perspective on the topic with each chapter referring the reader to the relevant key reading. Cardiac Anesthesia and Postoperative Care in the 21st Century is aimed at new consultants in cardiac anesthesia and intensive care, residents, and fellows. It may also be of interest to perfusionists and is a refreshing update for the experienced cardiac anesthesiologist.

"An essential resource for anesthesiologists new to the cardiac operating room Cardiac Anesthesia and Transesophageal Echocardiography, Second Edition is a fast and effective way for anesthesia trainees to acquire the skills necessary to successfully navigate the cardiac operating room. Clinically focused, this unique guide imparts the basic principles of both cardiac anesthesia and echocardiography in a way that reflects the realities of real-world practice. Whether you are looking for a concise, easy-to-read introduction to cardiac anesthesiology or a primer on incorporating the basic principles of cardiac anesthesiology and perioperative echocardiography into real-world practice, Cardiac Anesthesia and Transesophageal Echocardiography is the trusted one-stop guide to mastery of these two critical topics. This edition includes online access to nearly 100 narrated, labeled TEE clips that illustrate normal and abnormal echocardiographic views. Each clip is keyed to a specific passage in the text, which provides the reader with a true multimedia learning experience"-- Provided by publisher.

The past 50 years have witnessed the growth and evolution of clinical electrophysiology from a field whose goals were simply to understand of the mechanisms of arrhythmia to one of significant therapeutic impact. The development and refinement of implantable devices and catheter ablation have made non-pharmacological therapy a treatment of choice for most arrhythmias encountered in clinical practice. Cardiac Arrhythmias: From Basic Mechanism To State-of-the-Art Management provides an electrophysiologic approach to arrhythmias predicated on the hypothesis that a better understanding of the mechanisms of arrhythmias will lead to more successful and rationally chosen therapy. It encompasses the anatomy of arrhythmias, diagnostic methods, comorbid diseases, and the treatment of all forms of cardiac arrhythmias. It discusses modern ablation and mapping techniques, while reviews the methodology required to define the mechanism and site of origin of arrhythmias, so that safe and effective therapy can be chosen. It will thus be of interest to all involved in the management of these patients, from clinical cardiac electrophysiologists themselves to clinical cardiologists, interventionalists, cardiac surgeons, emergency medicine physicians and researchers in basic cardiac science.

Like the first edition, this book represents our personal approach to patients with cardiac arrhythmias. Nonetheless, it would be unrealistic to expect 3 electrophysiologists to have entirely uniform approaches to diagnosis and therapy. Hence, the primary author's views in individual chapters prevailed when there were minor differences in approach. Each of us reviewed all the chapters and made recommendations for change. In the end, we did not feel there were any substantial differences in our approach to patient care and were comfortable in signing off on the total content.

This book provides up-to-date, user-friendly and comprehensive guidance on the evaluation, diagnosis, and medical and surgical treatment of cardiac arrhythmias. This ensures that that this title aids every trainee and practicising cardiologist, cardiac electrophysiologist, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients. Cardiovascular Medicine: Cardiac Arrhythmias, Pacing and Sudden Death covers every aspect of cardiac arrhythmias, from cardiac signs and symptoms through imaging and the genetic basis for disease to surgery, interventions, treatment and preventive cardiology. This coverage is presented with consistent chapter organization, clear design, and engaging text that includes user-friendly features such as tables, lists and treatment boxes.

The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives. In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering.

Part I. Ischemic Heart Disease -- 1. Pre-analytical factors and analytical issues affecting interpretation of cardiovascular biomarkers -- 2. Troponin basics for clinicians -- 3. Unique aspects of high sensitivity assays: what are they, why do we need them, and how do we use them? -- 4. Evaluation of patients presenting with chest pain in the emergency department: where do troponins fit in? -- 5. Using cardiac troponins in patients with acute myocardial infarction -- 6. What is a Type 2 myocardial infaction: how is it recognized and what should one do to establish that diagnosis? -- 7. Use of cardiac troponin in patients with heart failure -- 8. Elevated cTn in other acute situations such as atrial fibrillation, sepsis, respiratory failure, and gastrointestinal bleeding -- 9. Use of cTn for detection of more chronic disease states -- 10. Use of high-sensitive cTn assays for the evaluation of patients potentially at risk for cardiovascular disease -- 11. Other biomarkers in acute coronary syndrome -- 12. Newer lipid markers: apolipoprotein B, LDL particle concentration, and triglyceride-rich lipoproteins, when are they needed? -- Part II. Heart Failure -- 12. Natriuretic peptides: physiology for the clinician -- 14. Natriuretic peptides: basic analytic considerations -- 15. Natriuretic peptide use in screening in the community -- 16. Natriuretic peptide use in the emergency department -- 17. Heart failure: natriuretic peptide use in the hospital -- 18. Natriuretic peptide guided therapy in outpatient heart failure management -- 19. Caveats using natriuretic peptide levels -- 20. Gaps in our biomarker armamentarium: what novel biomarkers might be synergistic in patients with acute disease -- 21. Biomarkers in heart failure: ST2 -- 22. Biomarkers in heart failure: procalcitonin -- 23. Novel biomarkers in heart failure: adrenomedullin and proenkephalin -- 24. Biomarkers in specific disease states: cardio-oncology -- 25. Biomarkers of sarcopenia and mitochondrial dysfunction -- 26. Biomarkers in arrhythmias, sudden death, and device therapy -- 27. Biomarkers in cardio-renal dysfunction -- 28. Biomarkers in heart failure with preserved ejection fraction -- Index.

Congenital cardiology continues to advance at a rapid pace, with recent decades witnessing exceptional growth in the number and range of catheter-based interventions. This handbook is an ideal, up-to-date guide to the application of these procedures across the entire patient age range, from fetal life through to adulthood. Clear instruction is offered on techniques of vascular access, valve dilatation, angioplasty, stent implantation, defect closure, defect creation, pulmonary valve implantation, and the hybrid approach, as well as miscellaneous other procedures. Topics are approached using a step-by-step format, ensuring that the reader will immediately be able to access information relevant to daily practice. Many explanatory figures and drawings are included in each chapter in order to clarify further how to plan, perform, and evaluate diagnostic and interventional procedures in the field of congenital heart disease. Attention is drawn to important tips and tricks that will assist in achieving optimal outcomes. Besides the detailed descriptions of procedures, background information is provided on patient preparation, anesthesia, instrumentation, and hemodynamics. At the end of the book, an appendix includes additional general equations and BSA and oxygen consumption charts. This handbook will be an invaluable tool and a comprehensive companion for all who work in the field of congenital heart disease.

The second edition of this handbook is an up-to-date guide to the application of catheter-based interventions across the entire age range of congenital heart disease patients, from fetal life through to adulthood. It considers the changes and improvements that have occurred during the last few years in terms of new procedures, new tools and devices (in particular in the field of valves), new imaging and pre-procedural strategies, such as 3D-printing, 3D- rotational angiography and fusion imaging. It provides readers with clear instructions on techniques for vascular access, valve dilatation, angioplasty, stent implantation, defect closure, defect creation, pulmonary valve implantation and on the hybrid approach, as well as on various other procedures. As in the first edition, topics are approached using a step-by-step format, ensuring that readers can immediately access the information relevant to their daily practice. Numerous explanatory figures and drawings are included in each chapter in order to further clarify how to plan, perform and evaluate diagnostic and interventional procedures in the field of congenital heart disease. It also highlights important tips and tricks that will assist health operators in achieving optimal outcomes, and includes an appendix with additional general equations and BSA, and oxygen consumption charts. This practical guide will be a valuable resource for surgeons and cardiologists in their daily clinical practice.

Cardiac computed tomography (CT) has become a highly accurate diagnostic modality that continues to attract increasing attention. This extensively illustrated book aims to assist the reader in integrating cardiac CT into daily clinical practice, while also reviewing its current technical status and applications. Clear guidance is provided on the performance and interpretation of imaging using the latest technology, which offers greater coverage, better spatial resolution, and faster imaging while also providing functional information about cardiac diseases. The specific features of scanners from all four main vendors, including those that have only recently become available, are presented. Among the wide range of applications and issues discussed are coronary calcium scoring, coronary artery bypass grafts, stents, and anomalies, cardiac valves and function, congenital and acquired heart disease, and radiation exposure. Upcoming clinical uses of cardiac CT, such as hybrid imaging, preparation and follow-up after valve replacement, electrophysiology applications, myocardial perfusion and fractional flow reserve assessment, and plaque imaging, are also explored.

Over the past few decades there have been major advances in computed tomography (CT) to improve the performance of cardiac imaging. Thanks to the improved scanning speed, power boost tubes, and increased-width detectors, the latest CT technology delivers greater coverage, better spatial and temporal resolution, and functional information on cardiac diseases. Focusing on cardiac CT imaging, this book offers case-based information on cardiac diseases, presents the current technical status, and highlights applications, helping readers systematically understand how cardiac CTs are performed and interpreted in clinical practice. Divided into six chapters, it broadly discusses the characteristics of CT imaging and its applications to coronary artery disease (CAD); non-atherosclerotic coronary artery disease; congenital heart disease; cardiac neoplasms; cardiomyopathy and aortic diseases.

This book is a state-of-the art reference that presents computed tomography (CT) and magnetic resonance (MR) cardiac imaging for the diagnosis and treatment planning of adult congenital heart disease (ACHD). It highlights the advantages of CT and MR in the management of ACHD, focusing on the complementary collaboration between these two modalities where possible. CT and MR aids in the evaluation of cardiac anatomy and function, leading to the demonstration of the full spectrum of abnormalities in complex cardiac malformations and the discovery of anomalous pathologies missed by other imaging techniques.

This book collates the current knowledge in cardiovascular CT and presents this in a clinically relevant and practical format appropriate for all who use the modality. The field has experienced continued rapid evolution due to advances in technology, the expanded spectrum of cardiovascular applications and significant growth in published data. As increasing numbers have access to CT scanners, Cardiac CT Imaging: Diagnosis of Cardiovascular Disease, Third Edition provides all the relevant information on the use of this modality. This extensive revision of this well-respected textbook brings the reader up-to-date with the technique, with chapters supplied by an experienced set of contributing authors and representing the full spectrum of cardiac CT. It thus represents an essential purchase for those preparing for board examinations, all training to use this modality, and those already using cardiovascular CT on a day-to-day basis who want to stay current.

This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs are examined. This revised edition is thoroughly updated and addresses the entire spectrum of heart disorders, such as hypertension, angina, myocardial infarction, heart failure, arrhythmias, cardiac arrest, and dyslipidemias. New chapters include endocrine heart diseases, management of cardiomyopathies, and newer agents. In addition, topics such as cardiac drugs in pregnancy and lactation and drug interactions are covered. Cardiac Drug Therapy, Eighth Edition, is an authoritative and clinically relevant resource for cardiologists, cardiology fellows, and internists.

In the western world, the risk of cardiovascular disease in pregnancy has grown due to the increasing age at the first pregnancy and the worldwide obesity epidemic leading to early diabetes and hypertension. As a result more women are requiring drug therapy during pregnancy and some data has shown an altered pharmacodynamic profile in pregnant women when compared to the non-pregnant population. Cardiac Drugs in Pregnancy presents up-to-date research for the treatment of cardiovascular disease during pregnancy, and discusses the most important indications of drug usage in pregnancy and postpartum. The book aims to assess the potential risk of drugs and their possible benefit against each other, making it an essential read for a wide range of health professionals involved in cardiac drug therapy in pregnancy.

This book offers a comprehensive review of clinical cardiac electrophysiology in a question and answer format. Chapters contain over 200 questions divided into 9 chapters, each organized by cardiac electrophysiology topic. Each question is followed by the correct answer with a detailed explanation along with references for further reading. Important concepts are highlighted and supported by over 200 illustrations and high resolution images. The book addresses a broad range of topics that are important when studying for the initial certification or recertification of the clinical cardiac electrophysiology board examination. It is also highly relevant for daily clinical practice in cardiology and cardiac electrophysiology. Topics covered in the book include: Review of basic and clinical cardiac electrophysiology principles associated with cardiac arrhythmias The evaluation and management of patients with cardiac rhythm disorders Review of pharmacologic and nonpharmacologic therapies for the treatment of arrhythmias Clinical indications, fundamental principles and electrical characteristics of implantable cardiac electronic devices such as pacemakers and defibrillators Clinical, electrocardiographic, and electrophysiologic characteristics of specific cardiac arrhythmia syndromes Cardiac Electrophysiology Board Review is a must-have resource for cardiology and cardiac electrophysiology trainees as well as attending physicians preparing for the certification or recertification examination. It may also be a useful guide for cardiologists, cardiac electrophysiologists and all clinicians who wish to further their understanding of heart rhythm disorders. .

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world.Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more!

This book reflects how the concern regarding the effects of radiation exposure in patients and health personnel involved in cardiac electrophysiology (EP) has inspired new developments in cardiac electrophysiology procedures without the use of fluoroscopy. This innovative method has become a subspecialty within electrophysioloy with several EP laboratories around the world adopting an exclusive non-fluoroscopy approach. It features guidance on how to use three dimensional (3D) navigation systems, ablation energy sources and zero-fluorospic implantation of cardiac electronic devices. The potential complications and associated preventative methods with utilising RFCA are also described. Cardiac Electrophysiology Without Fluoroscopy offers a thorough description of the technique correlated to the performance of EP procedure without the use of radiation, and provides a valuable resource for those seeking a practically applicable guide on how to perform cardiac EP without fluoroscopy, including practising and trainee electrophysiologists, cardiac imagers, general cardiologists and emergency medicine physicians.

This book is primarily for pediatric and adult emergency room physicians, primary care providers, hospitalists, and nurses. It will also be useful for critical care specialists, cardiologists and trainees at all levels. Cardiac Emergencies in Children describes the pathophysiology of a diverse group of congenital and acquired heart conditions and presents a therapeutic rationale for treating children presenting with these conditions under life-threatening conditions. The book discusses the effects of surgery on hemodynamics and how to manage these effects. Also described are the daily challenges faced by physicians, including identifying a child with heart disease, interpreting chest radiographs, ECGs, and laboratory findings, and beginning appropriate therapies.

Part I. Control of Energy Metabolism -- A Primer on Carbohydrate Metabolism in the Heart / Heinrich Taegtmeyer -- Lipoproteins: A Source of Cardiac Lipids / Konstantinos Drosatos and Ira J. Goldberg -- Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart / Andrea Wan and Brian Rodrigues -- Control of Myocardial Fatty Acid Uptake / Jan F. C. Glatz and Joost J. F. P. Luiken -- Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes / Gary D. Lopaschuk -- Transcriptional Control of Mitochondrial Biogenesis and Maturation / Rick B. Vega , Teresa C. Leone , and Daniel P. Kelly -- Relationship Between Substrate Metabolism and Cardiac Efficiency / Ellen Aasum -- Acetylation in the Control of Mitochondrial Metabolism and Integrity / Michael N. Sack -- Part II. Alteration in Energy Metabolism -- Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes / Vijay Sharma and John H. McNeill -- The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart / Craig A. Lygate and Stefan Neubauer -- Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure / Stephen C. Kolwicz and Rong Tian -- Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury / Vijayan Elimban , Paramjit S. Tappia , and Naranjan S. Dhalla -- The Role of AMPK in the Control of Cardiac Hypertrophy / Nikole J. Byrne, Miranda M. Sung, and Jason R. B. Dyck -- The Role of Incomplete Fatty Acid β-Oxidation in the Development of Cardiac Insulin Resistance / John R. Ussher -- Part III. Optimization of Energy Metabolism -- Metabolic Therapy for the Ischemic Heart / Giacinta Guarini , Alda Huqi , and Mario Marzilli -- Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients / Rui Yan , Jin Wei , and Dengfeng Gao -- Cardiac Metabolic Protection for the Newborn Heart / J. Carter Ralphe and Thomas D. Scholz -- Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease / Michael A. Portman and Aaron K. Olson.

This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM's role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.

Cardiac fibrosis and heart failure-- cause or effect? -- Fibroblast activation in the infarcted myocardium -- Mechanical and matrix regulation of valvular fibrosis -- Bone marrow-derived progenitor cells, micro-RNA, and fibrosis -- The stressful life of cardiac myofibroblasts -- Pathogenic origins of fibrosis in the hypertensive heart disease that accompnaies aldosternoism -- Embryological origin of valve progenitor cells -- Diverse cellular origin of valve progenitor cells -- Diverse cellular origins of cardiac fibroblasts -- Non-canonical regulation of TGF-β1 signaling: a role for Ski/Sno and YAP/TAZ -- Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart -- Current and future strategies for the diagnosis and treatment of cardiac fibrosis -- Remodelling of the cardiac extracellular matrix: role of collagen degradation and accumulation in pathogenesis of heart failure -- Matrix metalloproteinase 9 (MMP-9) -- Collagen processing and its role in fibrosis -- Mechanisms of cardiac fibrosis and heart failure -- Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes -- Extracellular matrix and cardiac disease: surgical and scientific perspectives -- The role or neurohumoral activation in cardiac fibrosis and heart failure -- Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart -- Cardiac tissue engineering for the treatment of heart failure post-infarction -- Mechanisms in cardiac valve failure and the development of tissue engineered heart valves -- Index.

"The Core Review Series will be the first and only reference specifically designed for the new exam. This title will consist of approximately 300 questions, in a format similar to the exam with image-rich MCQs. Answers to the questions will be discussed in a concise manner along with explanations of each choice followed by relevant references. Cardiac Imaging: A Core Review will cover questions ranging from basic imaging, normal anatomy, all diseases relative to cardiac imaging, all modalities, and postoperative appearances of devices. Key Features Image-rich review text with 300 questions-includes answers and explanations. On average, each question will have 1-2 corresponding images. Bundled with an Inkling version for interactive and mobile review. High-yield tables embedded in the answers. Answers to the questions with explanations on why a particular answer choice is correct and why the other choices are incorrect"-- Provided by publisher.

"The second edition of the Cardiac Imaging: A Core Review builds on the success of the first edition by covering the essential aspects of cardiac imaging in a manner that serves as a guide for residents to assess their knowledge and review the material in a format that is like the ABR core examination"-- Provided by publisher.

Introduction to cardiac imaging / Lawrence M. Boxt and Suhny Abbara -- Echocardiography / Kaitlyn My-Tu Lam and Mary Etta E. King -- Cardiac magnetic resonance imaging / Amgad N. Makaryus and Lawrence M. Boxt -- Cardiac computed tomography / Amgad N. Makaryus and Lawrence M. Boxt -- Coronary heart disease / Nagina Malguria and Suhny Abbara -- Myocardium, pericardium, and cardiac tumor / Nagina Malguria, Stephen W. Miller, and Suhny Abbara -- Valvular heart disease / Suhny Abbara and Nagina Malguria -- Thoracic aortic disease / Steven L. Hsu, Sanjeeva Kalva, John G. Santilli, and Stephen W. Miller -- Congenital heart disease / B. Kelly Han, Stephen W. Miller, and Lawrence M. Boxt.

Echocardiography-Physics basics -- Views -- Chamber quantification -- Valves: AS, AR, MS, MR, TS, TR, PS, PR subchapters -- Artificial valves basics, AS, AR, MS, MR, TS, TR, PS, PR -- Diastology -- Pericardial disease -- Cardiac Masses -- Non-invasive catheterization -- Basic cardiac anomalies -- Ischemic heart disease -- CHF -- Cardiomyopathies -- Systemic diseases -- Aortic disease -- Basics of bubble and contrast studies -- SPECT-Basics of SPECT Radioisotopes -- Ischemia work up -- Viability work up -- CT- Technique -- Indications -- Sample images -- MRI-Basic technique -- Indications -- Function, Viability -- Masses, CMP, scar, amyloid, HCM images -- Pericardium: inflammation, constriction vs. restriction.

"Using a multidisciplinary, team-oriented approach, this unique title expertly covers all the latest approaches to the assessment, diagnosis, and treatment of patients with critical cardiac illness. Led by Dr David L. Brown, a stellar team of authoritative writers guides you through cardiac pathophysiology, disease states presenting in the CICU, and state-of-the-art advanced diagnosis and therapeutic techniques. A visually appealing format, new chapters, and thorough updates ensure that you stay on the cutting edge of this rapidly advancing field"--Publisher's description.

Anatomy of the Cardiac Lymphatic System. A General Outline of the Cardiac Lymphatic System / Marios Loukas, Sameer Shah, Shivayogi Bhusnurmath, Bharti Shivayogi Bhusnurmath -- Development and Patterning of the Cardiac Lymphatic Network / Jörg Wilting, Jörg Männer -- The Cardiac Lymphatics and Heart Disease. The Link Between Lymphatic Obstruction and Congenital Heart Disease / Manish Bansal -- The Role of Lymphatics in Atherogenesis, Myocardial Infarction, Congestive Heart Failure, and Cardiac Transplantation / Shin Lin, Stanley G. Rockson -- The Lymphatics in Normal and Pathological Heart Valves / Ivana Kholová, Galina Dragneva, Seppo Ylä-Herttuala -- Therapeutic Applications Targeting the Cardiac Lymphatics in Heart Disease / Jae-Hyeong Park, Jin-Ok Jeong -- Imaging the Lymphatic System in Heart Transplantation and Its Immunological Implications / Kathryn Brown, Lindsey A. Edwards, Wilson Wong -- Cardiac Lymphatic Signaling. Tie Receptor Signaling in Cardiac Lymphangiogenesis / Xianghu Qu, H. Scott Baldwin -- VEGF Receptor Signaling in the Cardiac Lymphatics / Alexey Dashkevich, Karl B. Lemström, Antti I. Nykänen -- Hypoxia and the Cardiac Lymphatic System / Todd R. Wuest, P. Charles Lin -- The Potential of the Epicardium to Act as a Source of Lymphatic Cells / Linda Klotz, Paul Riley.

This book presents the main cardiac pathologies, providing a helpful guide featuring clinical cases and electronic supplementary material. There are several systematic books on cardiac magnetic resonance, which approach the different pathologies and related pathophysiology in a general manner, and these are useful for readers at an early stage in their medical careers. However, when it comes to individual patients (during the acquisition of images and reporting activities) there is no book providing operative protocols or systematic descriptions of details to look for. In the eight chapters (Cardiomyopathies, Myocarditis, Ischemic Heart Disease, Valvular Heart Diseases, Cardiac Masses, Pericardial Diseases, Congenital Heart Disease, and Miscellanea), the individual pathology is illustrated with a clinical case. The cases are divided into four sections: An introduction with a short medical history and the purpose of the diagnostic CMR A detailed CMR acquisition protocol CMR images, indicating purpose, method, analysis and meaning of the image, as well as videos. Concluding paragraph with the final diagnosis reached on the basis of the findings obtained in each image This book, collecting one hundred one clinical cases covering a broad spectrum of cardiac diseases, is an invaluable tool for radiologists and cardiologists.

1. Introduction. The specificity of geriatric cardiology -- 2. Epidemiology of heart disease in the elderly -- 3. Molecular mechanisms of cardiovascular aging -- 4. Frailty and heart disease -- 5. Evidence based medicine and evidence biased medicine in geriatric cardiology. From the trial to the real word -- 6. Polypharmacy -- 7. Syncope and Unexplained Falls in the elderly.-- 8. Hypertension in the oldest old, beyond the guidelines.-- 9. New challenges in aortic stenosis in the elderly: from epidemiology to TAVI.-- 10. The aging kidney and cardiovascular disease -- 11. Risk assessment in cardiac and non-cardiac surgery in the older patient -- 12. Atrial fibrillation in the elderly -- 13. Cardiac devices in the elderly -- 14. Management of acute coronary syndromes in the elderly -- 15. Cardiac surgery in the oldest old.

Introduction -- Physiopathology and toxic drugs heart effects -- Radiotherapy heart effects -- Cardiac imaging technology in cardio-oncology -- Evaluation of the oncologic patient before, during and after chemotherapy -- What drug/what possible complication -- What cancer type/what possible drug -- what cancer/what possible complication -- Management (prevention/diagnosis/evaluation/therapy) of hypertension -- Management (prevention/diagnosis/evaluation/therapy) of coronary disease and thrombo-embolic complication -- Management (prevention/diagnosis/evaluation/therapy) of arrhythmic complication -- Management (prevention/diagnosis/evaluation/therapy) of systolic dysfunction.

As our population ages and multiple factors contribute to an increased prevalence of cardiovascular disease, more patients than ever before will be candidates for implantable devices as part of their treatment for heart rhythm abnormalities. Electrophysiologists have a widening array of sophisticated devices from which to choose, and important new data about efficacy, long-term outcomes and possible complications has emerged, impacting how devices are chosen and utilized. Overall, the management of patients with pacemakers and ICDs and other devices remains a complex topic and the need for.

"In many ways, this textbook mirrors the development of the field of cardiac device placement and management. The original version of this text was written by Drs. Seymour Furman, David Hayes, and David Holmes, pioneers and founders of interventional electrophysiology and device management. The goals of the present text remain similar to the original intent, that is, to provide a relatable, practical approach without ignoring the rigors of fundamental principles while retaining the flexibility in the professional's mind to embrace new technology. Updates on resynchronization therapy, subcutaneous defibrillators, leadless devices, and improvements in lead extraction have been included in this text. We continue to stay away from an encyclopedic approach but rather focus on a usable, practical, and intuitive approach for problem solving in the day-to-day practice of a cardiac electrophysiology professional. As with all prior editions, we owe a great debt of gratitude to all the contributors who have tirelessly updated their sections and have done multiple revisions. We also have to thank our patients and nursing staff who provide us with material to allow us to learn to a point where we can try and teach troubleshooting approaches, etc. We received tremendous support from various device manufacturers, their engineers, and their published data material. These include assistance from Biotronik, Boston Scientific, Medtronic, and Abbott Medical"-- Provided by publisher.

With a growing population of young patients with congenital heart disease reaching adulthood, this unique new book offers an in-depth guide to managing the challenges and issues related to device therapy in this patient group. -The only book resource dedicated to pacing, cardiac resynchronization therapy and ICD therapy for the pediatric and congenital heart disease patient -Contains practical advice for pacemaker and ICD implantation, programming, trouble-shooting, managing complications and follow up -Up-to-date with the latest in device technology -Contains multiple graphics, device electrogram tracings, and radiographic images for clarity -Includes video clips and over 150 multiple choice questions with extended answers on companion website, ideal for self test -An invaluable resource for both the specialist pediatric cardiologist and the general cardiologist responsible for children with heart disease and pacing devices.

General Considerations and Anatomy -- Cardiac Electrophysiology -- Cardiac Imaging -- Current Therapeutics for Cardiac Disease -- The Heart at Autopsy -- Embryology of the Heart -- Ischemic Heart Disease -- Myocarditis/Inflammatory Cardiomyopathy -- Valvular Heart Disease -- Transplant Pathology -- Cardiomyopathies -- Cardiac Tumors -- Congenital Heart Disease -- Sudden Cardiac Death.

This thorough review of cardiac and cardiovascular pathology covers ischemic heart disease, myocarditis, valvular disease, transplant pathology, cardiomyopathy, cardiac devices, congenital heart disease and more, illustrated with macro- and microscopic images.

Part I Introduction to Cardiac Rehabilitation -- 1. General Principles of Exercise Testing in Cardiac Rehabilitation -- 2. General Principles of Nutrition Support in Cardiac Rehabilitation -- 3. Psychological Care of Cardiac Patients -- Part II Cardiac Rehabilitation in Specific Cases -- 4. Exercise Training in Cardiac Rehabilitation -- 5. Angina Pectoris -- 6. Diabetes Mellitus Type 2 and Cardiovascular Disease -- 7. Cardiac rehabilitation after acute myocardial infarction; the influence of psychosocial disorders -- 8. Stable coronary artery disease: Exercise based cardiac rehabilitation reduces the risk of recurrent angina after PCI in the case of arterial hypertension -- 9. Rehabilitation of patients after CABG/sternotomy -- 10. Congestive Heart Failure: Stable Chronic Heart Failure Patients -- 11. Cardiac Rehabilitation in Patients with Implantable Cardioverter Defibrillator -- 12. Rehabilitation in Patients with Cardiac Resynchronization Therapy -- 13. Exercise Training in Congenital Heart Diseases -- 14. Pacemaker Implantation -- 15. Patient with Peripheral Artery Disease.

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.

This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.

Intro -- Preface -- Contents -- Part I: Perioperative Care and Cardiopulmonary Bypass -- 1: Cardiac Catheterization -- History of Cardiac Catheterization -- Invasive Diagnostic Coronary Angiography -- Indications -- Pre-procedure Preparation -- Technical Aspects of the Procedure -- Access -- Pharmacology -- Catheter Selection and Manipulation -- Angiographic Views -- Post-procedure Care -- Sheath Removal and Closure Devices -- Coronary Angiogram Analysis -- Complications -- Right Heart Catheterization -- Indications -- Procedure -- Complications -- Interpreting Haemodynamics -- Right Atrium Right Ventricle -- Pulmonary Artery -- Pulmonary Capillary Wedge Pressure -- Conclusion -- References -- 2: Fractional Flow Reserve -- Introduction -- Definitions -- How Was This Cut-Off Decided? -- FFR Compared to Other Non-invasive Diagnostic Techniques -- Limitations of Pressure Wire Measurements -- Intravascular Ultrasound and FFR -- Assessing Left Main Stem Stenosis Using FFR -- FFR Use Pre Coronary Artery Bypass Grafting -- Main Outcome Studies with FFR -- DEFER Trial [24] -- FAME Trial [9] -- FAME 2 Trial [10] -- COMPARE ACUTE Trial [27] -- Instantaneous Wave-Free Pressure Ratio (iFR) Conclusions -- References -- 3: Echocardiography -- Introduction -- Essential Ultrasound Theory for Echocardiography -- Modalities of Echocardiography -- Assessment of Myocardial Function -- Left Ventricular Systolic Function -- Changes in Volumes/Dimensions -- Indices of Global Contractility -- Systolic Strain -- Regional Contractile Function -- Right Ventricular Systolic Function -- Diastolic Function -- Assessment of Valve Pathology -- Aortic Stenosis -- Aortic Regurgitation -- Mitral Stenosis -- Mitral Regurgitation -- Tricuspid Valve Assessment -- Pulmonary Valve Assessment Infective Endocarditis -- Echo Findings in Endocarditis -- Pericardial Disease -- Masses -- Contrast Echocardiography -- Stress Echocardiography -- Stress Echo for Coronary Artery Disease -- Stress Echo for Aortic Stenosis -- Stress Echo for Mitral Regurgitation -- Other Indications for Stress Echocardiography -- Transesophageal Echocardiography (TEE) -- Pre-operative TEE -- Intraoperative TEE -- Conclusions -- References -- 4: Cardiac Computed Tomography and Magnetic Resonance Imaging -- Introduction -- Technology -- Computed Tomography (CT) -- Magnetic Resonance Imaging (MRI) Clinical Applications of CT and MRI -- Coronary Artery Disease -- Myocardial Ischaemia -- Myocardial Viability -- Heart Failure and Cardiomyopathies -- Valvular Heart Disease -- Congenital Heart Disease -- Pericardial Diseases -- Cardiac Tumours -- Aortic Diseases -- Post-surgical Patient -- Conclusion -- References -- 5: Assessment of Myocardial Viability -- Introduction -- Assessment of Myocardial Viability -- Electrocardiogram (ECG) -- Baseline 2D Echocardiography -- Dobutamine Stress Echocardiography -- Single Photon Emission Computerized Tomography (SPECT)

I. Introduction -- II. Technical Prerequisites -- III. Congenital Anomalies of the Heart and Great Vessels -- IV. Acquired Diseases of the Heart and Great Vessels.

Clinical judgment in critical care -- Cardiovascular anatomy and physiology -- Indications for cardiac surgery -- Preoperative cardiac surgery nursing evaluation -- Heart valve surgery -- Cardiopulmonary bypass and off-pump coronary artery bypass -- Minimally invasive cardiac surgery -- Recovery of anesthesia following cardiac surgery -- Hemodynamic monitoring -- Intra-aortic balloon pump -- Mechanical ventilation after open heart surgery -- Pharmacological support following cardiac surgery -- Postoperative complications of cardiac surgery and nursing interventions -- Pain management -- Postoperative dysrhythmias -- Neurologic complications -- Fluid and electrolyte imbalances following cardiac surgery -- Wound care -- Bridge to transplant and cardiac transplantation -- Complications of obesity of the cardiac surgery patient -- Cardiogenetics -- Nutritional issues in the patient undergoing cardiac surgery -- Psychological support for the patient undergoing cardiac surgery and the family -- Rehabilitation and care of the cardiac surgery patient on discharge -- Post-ICU care and other complications.

Section I. Fundamentals -- Section II. Perioperative/intraoperative care -- Section III. Ischemic heart disease -- Section IV. Aortic valve disease -- Section V. Mitral valve disease -- Section VI. Valvular heart disease (other) -- Section VII. Surgery of the great vessels -- Section VIII. Surgery for cardiac arrhythmias -- Section IX. Other cardiac operations -- Section X. Transplant and mechanical circulatory support.

Section I: Fundamentals -- Chapter 1: History Of Cardiac Surgery -- Chapter 2: Surgical Anatomy Of The Heart -- Chapter 3: Cardiac Surgical Physiology -- Chapter 4: Cardiac Surgical Pharmacology -- Chapter 5: Cardiovascular Pathology -- Chapter 6: Computed Tomography Of The Adult Cardiac Surgery Patient: Principles And Applications -- Chapter 7: Risk Assessment And Performance Improvement In Cardiac Surgery -- Chapter 8: Simulation In Cardiac Surgery -- Chapter 9: The Integrated Cardiovascular Center -- Section Ii: Perioperative/intraoperative Care -- Chapter 10: Preoperative Evaluation For Cardiac Surgery -- Chapter 11: Cardiac Anesthesia -- Chapter 12: Echocardiography In Cardiac Surgery -- Chapter 13: Extracorporeal Circulation -- Chapter 14: Transfusion Therapy And Blood Conservation -- Chapter 15: Deep Hypothermic Circulatory Arrest -- Chapter 16: Myocardial Protection -- Chapter 17: Postoperative Care Of Cardiac Surgery Patients -- Chapter 18: Temporary Mechanical Circulatory Support -- Section Iii: Ischemic Heart Disease -- Chapter 19: Myocardial Revascularization With Percutaneous Devices -- Chapter 20: Myocardial Revascularization With Cardiopulmonary Bypass -- Chapter 21: Myocardial Revascularization Without Cardiopulmonary Bypass -- Chapter 22: Myocardial Revascularization After Acute Myocardial Infarction -- Chapter 23: Minimally Invasive Myocardial Revascularization -- Chapter 24: Coronary Artery Reoperations -- Chapter 25: Surgical Treatment Of Complications Of Myocardial Infarction, Ventricular Septal Defect, Myocardial Rupture, And Left Ventricular Aneurysm -- Section Iv: Aortic Valve Disease -- Chapter 26: Pathophysiology Of Aortic Valve Disease -- Chapter 27: Aortic Valve Replacement With A Mechanical Cardiac Valve Prosthesis -- Chapter 28: Stented Bioprosthetic Aortic Valve Replacement -- Chapter 29: Stentless Aortic Valve And Root Replacement -- Chapter 30: Aortic Valve Repair And Aortic Valve-sparing Operations -- Section V: Mitral Valve Disease -- Section Vi: Valvular Heart Disease (Other) -- Section Vii: Surgery Of The Great Vessels -- Section Viii: Surgery For Cardiac Arrhythmias -- Section Ix: Other Cardiac Operations -- Section X: Transplant And Mechanical Circulatory Support.

This book comprehensively reviews a selection of cases resulting from complications that can occur in cardiac surgical procedures. It details the science behind each potential complication along with a range of available strategies to rectify the issues, including those applicable to minimally invasive techniques. Chapters are well illustrated and feature clinical pearls to reinforce key points. Cardiac Surgical Complications: Strategic Analysis and Clinical Review provides a practically applicable guide on how to successfully resolve and mitigate potential complications in cardiac surgery. Consequently, it is a valuable resource for all trainee and practicing cardiac surgeons, anesthesiologists and intensive care physicians.

Second generation codon optimized minicircle (CoMiC) for nonviral reprogramming of human adult fibroblasts / Sebastian Diecke ... [and 3 others] -- Scalable cardiac differentiation of human pluripotent stem cells as microwell-generated, size controlled three-dimensional aggregates / Celine L. Bauwens and Mark D. Ungrin -- Preparation and characterization of circulating angiogenic cells for tissue engineering applications / Aleksandra Ostojic ... [and 4 others] -- Isolation and expansion of C-kit-positive cardiac progenitor cells by magnetic cell sorting / Kristin M. French and Michael E. Davis -- Synthesis of aliphatic polyester hydrogel for cardiac tissue engineering / Sanjiv Dhingra, Richard D. Weisel, and Ren-Ke Li -- Fabrication of PEGylated fibrinogen : a versatile injectable hydrogel biomaterial / Iris Mironi-Harpaz, Alexandra Berdichevski, and Dror Seliktar -- Natural cardiac extracellular matrix hydrogels for cultivation of human stem cell-derived cardiomyocytes / Donald O. Freytes ... [and 4 others] -- Magnetically actuated alginate scaffold : a novel platform for promoting tissue organization and vascularization / Yulia Sapir ... [and 3 others.] -- Shrink-induced biomimetic wrinkled substrates for functional cardiac cell alignment and culture / Nicole Mendoza ... [and 4 others] -- Injectable ECM scaffolds for cardiac repair / Todd D. Johnson, Rebecca L. Braden, and Karen L. Christman -- Generation of strip-format fibrin-based engineered heart tissue (EHT) / Sebastian Schaaf ... [and 5 others.] -- Cell tri-culture for cardiac vascularization / Ayelet Lesman, Lior Gepstein, and Shulamit Levenberg -- Cell sheet technology for cardiac tissue engineering / Yuji Haraguchi ... [and 8 others] -- Design and fabrication of biological wires / Jason W. Miklas ... [and 3 others] -- Collagen-based engineered heart muscle / Malte Tiburcy ... [and 3 others] -- Creation of a bioreactor for the application of variable amplitude mechanical stimulation of fibrin gel-based engineered cardiac tissue / Kathy Y. Morgan and Lauren D. Black III -- Preparation of acellular myocardial scaffolds with well- preserved cardiomyocyte lacunae, and method for applying mechanical and electrical simulation to tissue construct / Bo Wang ... [and 3 others] -- Patch-clamp technique in ESC-derived cardiomyocytes / Jie Liu and Peter H. Backx -- Optogenetic control of cardiomyocytes via viral delivery / Christina M. Ambrosi and Emilia Entcheva -- Methods for assessing the electromechanical integration of human pluripotent stem cell-derived cardiomyocyte grafts / Wei-Zhong Zhu ... [and 3 others] -- Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs / Hung Nguyen ... [and 4 others].

Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.

Experimental studies in the field of cardiac valve biology are now demonstrating that the cardiac valve disease process is an active biology with risk factors analogous to vascular risk factors. Understanding the risk factors is also evolving rapidly, giving physicians and scientists insight into the cellular mechanisms and raising the possibility of treating these valve lesions with other options besides surgical valve repair. Our knowledge of right-sided valve lesions is also rapidly becoming important in the field of valvular medicine. Not only is the pathology different from left-sided valve lesions, but the hemodynamic compromise is more complex and difficult to treat in patients who develop tricuspid or pulmonic valve disease. Early diagnosis and careful management of this patient population is critical for long term outcomes in this patient population. Cardiac Valvular Medicine represents an overview of the most recent science, clinical trials and new discoveries in the field of valvular heart disease. The editor has assembled a team of highly experienced contributors to provide a thorough translational understanding of the current and future treatments for this patient population. Cardiologists, internists, family practice physicians, cardiac surgeons and basic scientists will all find enormous benefit from this textbook.

Cover -- Title -- Copyright -- Contents -- Contributors -- Foreword -- Preface -- Introduction -- Overview -- CVRN Certification -- About the Exam -- Eligibility Criteria -- How to Apply -- How to Contact American Nurses Credentialing Center -- Preparing for the Exam -- About the CV-BC™ Exam -- Chapter 1: Anatomy and Physiology -- Key Points -- Introduction -- Glossary Terms -- Properties of Cardiac Muscle -- Cellular Energy Metabolism: ATP -- Cardiac Cell Reproduction -- Autonomic Nervous System -- Hemodynamics -- Cardiac Output -- Preload, Contractility, and Afterload -- Heart Chambers Heart Valves -- Coronary Arteries and Veins -- Tissue Layers of the Heart -- Vascular Structure and Function -- Normal Function of the Vascular Endothelium -- Vascular Response to Injury -- Lymphatics -- Cerebral Circulation -- Chapter 2: The Cardiovascular Interview and History -- Key Points -- Introduction -- Glossary Terms -- The Patient Interview and History Identifying Data -- Identifying Data -- Current/Chief Concerns -- Review of Systems -- Glossary Terms -- Symptom Analysis -- Chest Discomfort -- Dyspnea -- Paroxysmal Nocturnal Dyspnea -- Abdominal Symptoms -- Palpitations -- Syncope Claudication -- Edema -- Key Signs of Cardiovascular Disease -- Coronary Heart Disease -- Heart Failure -- Valvular Heart Disease -- Cardiac Arrhythmias -- Peripheral Vascular Disease -- Medications -- Medical History Congenital and Childhood Illnesses -- Adult Illnesses -- Cardiovascular Diagnostic Tests and Procedures -- Surgical History -- Medications -- Allergies, Reactions, and Intolerances -- Family History -- Psychosocial and Social History -- Depression -- Cardiotoxic Substance Abuse -- Socioeconomic Status -- Self-Care -- Functional Assessment -- Lifestyle Factors Functional Activities -- Nutrition -- Physical Activity -- Sleep -- Therapeutic Communication/Motivational Interviewing -- Conclusion -- Clinical Pearls -- Chapter 3: Physical Assessment -- Key Points -- Introduction -- Glossary Terms -- Patient Interview -- Comprehensive History -- History of Present Illness -- Past Medical History -- Family History -- Social History -- Review of Systems -- General Survey -- Vital Signs -- Pulse -- Blood Pressure -- Orthostatic Vital Signs -- Pulse Pressure -- Respirations -- Temperature -- Oxygen Saturation -- Body Mass Index Cardiovascular Physical Assessment -- Carotid Arteries -- Inspection -- Palpation -- Auscultation -- Jugular Vein -- Inspection -- Palpation -- Hepatojugular Reflux/Abdominojugular Reflex -- Precordium -- Inspection -- Palpation -- Percussion -- Cardiac Auscultation -- Heart Sounds -- Cardiac Murmurs -- Pericardial Friction Rub -- Cardiovascular-Related Findings in Other Systems Eyes -- Eyes -- Inspection -- Fundoscopic Examination -- Integumentary -- Inspection -- Edema -- Peripheral Pulses -- Pulmonary -- Inspection -- Palpation -- Auscultation -- Percussion -- Abdominal

Extending from the outpatient management of cardiovascular and kidney disease, to hospital-based decision making in patients with cardio-renal disease and complex interfaces such as hemodialysis in patients with ventricular assist device support, this book serves as a single reference point for cardiology and nephrology clinicians and researchers dealing with the significant overlap areas between these two specialties. Chapters cover the physiology, biomarkers, therapeutic agents and full spectrum of these comorbidities and feature separate sections on cardiovascular and CKD evaluations, stratification of kidney transplant patients, lipid management in CKD, interventional strategies and hypertension. Leaders in cardiology, nephrology, hypertension and lipidology bring together the latest evidence with their collective clinical experience into this invaluable resource. This textbook is an essential resource for physicians and allied professionals practicing cardiology, nephrology, students and physician trainees, to deepen their understanding of this crucial field.

Intro -- Foreword -- Preface -- Acknowledgments -- Contents -- Contributors -- 1: Background: Immunology and Cancer -- References -- 2: Available Immunotherapy Drugs in Oncology -- Anti-PD-1 Agents -- Pembrolizumab -- Nivolumab -- Anti-PD-L1 Agents -- Atezolizumab -- Durvalumab -- Avelumab -- Anti-CTLA4 Agents -- Ipilimumab -- References -- 3: Immunotherapy Adverse Events -- Introduction -- Myocarditis -- Noninflammatory Myocardial Dysfunction -- Arrhythmias -- Pericardial Disease -- Vasculitis -- Myocardial Infarction -- References -- 4: Pathophysiology of Cardiac Toxicity -- Pathophysiology of Cardiac Toxicity: An Overview -- Cardiac Dysfunction and Heart Failure -- Vascular Disease -- Arrhythmias -- Pericardial and Valvular Disease -- References -- 5: Cardiac Risk Factors for Immunotherapy -- Why Evaluate the Cardiovascular Risk in Oncological Patients Who Have Undergone Immunotherapy? -- How to Quantify Cardiovascular Risk? -- Experimental Preventive Strategies for Immune Checkpoint Inhibitor (ICI)-Induced Cardiotoxicity: Evidence and Perspectives -- References -- 6: Diagnostic Methods of Cardiac Immunotherapy Damaging -- Introduction -- Clinical and Electrocardiographic Evaluation -- Echocardiography -- Myocardial Deformation Imaging -- Nuclear Imaging and Cardiac Magnetic Resonance -- Role of Biomarkers -- Role of Endomyocardial Biopsy -- Diagnostic Approach -- Conclusion -- References -- 7: Biomarkers of Early Cardiotoxicity -- Introduction -- Cardiac Troponins -- Brain Natriuretic Peptides -- New Emerging Biomarkers -- Conclusion -- References -- 8: Management of Patients with Cardiac Toxicity: The Point of View of the Cardiologist -- Introduction -- Atherosclerosis and Cardiovascular Events -- Myocarditis and Heart Failure -- Clinical Presentation -- Diagnosis -- Management -- ICI-Associated Pericarditis -- Diagnosis -- Management. Takotsubo Syndrome -- Arrhythmias -- Management -- Immunotherapy-Associated Vasculitis -- Immunotherapy-Associated Thromboembolism -- Screening and Surveillance -- Conclusion -- References -- 9: Management of Patients with Cardiac Toxicity: The Point of View of the Oncologist -- Introduction -- Mechanisms of Action of Cardiovascular ICI Adverse Events -- Myocarditis -- Epidemiology -- Physiopathology -- Clinical Presentation -- Laboratory and Imaging Findings -- Diagnosis and Management -- Pericarditis -- Epidemiology -- Pathophysiology -- Clinical Presentation -- Diagnosis -- Management -- Acute Coronary Syndrome (ACS) and Myocardial Infarction (MI) -- Epidemiology -- Physiopathology -- Clinical Presentation -- Diagnosis -- Management -- Takotsubo Cardiomyopathy -- Epidemiology -- Pathophysiology -- Clinical Presentation -- Diagnosis -- Management -- Dysrhythmias -- Epidemiology -- Pathophysiology -- Diagnosis -- Management -- Vasculitis -- Epidemiology -- Pathophysiology -- Clinical Presentation -- Diagnosis -- Management -- Cardiotoxicity Related to New Immunotherapy (CAR T Cell) -- Epidemiology -- Pathophysiology -- Diagnosis -- Management -- Baseline Assessment and General Principle of Management for Cardiovascular IRAE -- Conclusion -- References -- 10: Future Perspectives -- Introduction -- Basic and Translational Research -- Clinical Research -- Education and Training -- Service Organization and Provision -- References -- Index.

This book provides a comprehensive overview of the clinical challenges faced during the treatment of patients with cardiorenal syndrome (CRS). The bidirectional link that associates renal and cardiovascular diseases means that patients with CRS have an increased risk of hospital admission and mortality as a result of their coexistence yet, there are no agreed guidelines for their management. Cardio-Renal Clinical Challenges takes clinical presentations and clinical problems as its base, and then discusses the evidence for best management of common clinical problems and the reasons for the complex interplay between the cardiac and renal systems. In addition, the link between heart failure and chronic kidney disease (CKD) can impose a considerable epidemiological burden thus this text also aims to address the issue of organizing healthcare to maximize both the opportunities for prevention and best healthcare economic returns. This book will be of immediate value and practical interest to all consulting and trainee cardiologists and renal physicians.

Written by "internationally acclaimed" specialists, Cardio-Thoracic, Vascular, Renal and Transplant Surgery provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Cardio-Thoracic, Vascular, Renal and Transplant Surgery provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.

"The aim of this work is to integrate the basic and clinical science topics of the cardiovascular system in a deliberately clinically oriented review book. Approximately half of the medical schools in the United States have already implemented an integrated curriculum in their pre-clinical programs, a trend which is growing both nationally and internationally. This trend is due in part to the proven benefits of the evidence-based practice of medicine as well as the increasing number of integrative clinical vignette questions in the medical and healthcare professional license examinations."--Preface

This compact but comprehensive board review includes everything you need to successfully prepare for the ABIM Cardiology Board Review examination.-Features over 1200 questions with answers and clear explanations -Includes over 400 accompanying images -Covers all key areas of cardiology practice, from history/physicial examination through all major diseases/disorders, along with special topics, e.g. consultative cardiology, covered on the exam -Complements standard textbook reading -Written by an internationally-recognized, well-respected and well-published senior cardiologist, expert in valvular heart disease and cardiovascular imaging.

A point-of-care Q&A guide to clinical cardiology. It answers more than one-hundred of the clinical cardiology questions most frequently asked of the authors during consultation. It simulates the consultation process: consult question; data collection; synthesis of data; and, solution.

This book comprehensively covers the latest advances in cardiovascular medicine. Key diagnostic and treatment points are reviewed across a range of cardiovascular issues, including concurrent cardiac problems, patients with cancer, peri-operative surgical and post-trauma patients, patients in the emergency department, pregnancy in the obstetric units, and the care of critically ill patients in medical and surgical intensive care units. Cardiology Consult Manual provides a detailed and clinically relevant guide for the cardiology practitioner of the potential cardiac issues encountered within the cardiology consult service and also a range of professionals in related disciplines. It therefore provides an important resource for all cardiology trainees, fellows, practitioners and health care providers involved in the management of patients with cardiovascular disease. .

"Cardiology for Veterinary Technicians and Nurses is a comprehensive resource for veterinary technicians and nurses working with cardiovascular patients in veterinary practice. Offers a complete reference to veterinary cardiology targeted at veterinary technicians and nurses, summarizing fundamental knowledge on cardiovascular disease Covers dogs, cats, horses, ruminants, and camelids Provides information ranging from introductory to advanced for a thorough guide to cardiac conditions Presents detailed procedures for common cardiac catheterization techniques, including supplies required Includes photographs and illustrations to depict the concepts described"--Provided by publisher.

This book provides a guide for the management of patients with cardiovascular emergencies in the ER. It covers a broad range of the most important and frequent acute cardiovascular events including coronary syndromes, aortic syndromes, pulmonary embolism, and left heart failure. Pragmatic in nature, chapters discuss frequent clinical presentations in a thorough fashion while emphasizing a practical and concise approach to diagnosis and treatment. In addition, the book explores how new knowledge and technological advances are improving the quality of patient care in the emergency room, highlighting technological advances in the use of pharmacotherapy, biomarkers, and imaging techniques such as X-ray, echocardiography, CT, MRI, and nuclear. Cardiology in the ER: A Practical Guide is an essential resource for physicians and related professionals, residents, and fellows in cardiology, emergency medicine, intensive and critical care, and internal medicine.

Part I. Noninvasive Cardiology -- 1. Transthoracic echocardiography -- 2. Transesophageal echocardiography -- 3. Contrast echocardiography -- 4. Exercise stress testing -- 5. Cardiopulmonary exercise testing --6. Pharmacologic stress testing -- 7. Stress echocardiography -- 8. Single photon emission computed tomography -- 9. Positron emission tomography -- 10. Radionuclide angiography -- 11. Cardiac computed tomography (CT) -- 12. Cardiac magnetic resonance -- Part II. Critical Care -- 13. Central venous cannulation -- 14. Right heart catherization -- 15. Pericardiocentesis -- 16. Procedural sedation -- 17. Endotracheal intubation -- Part III. Electrophysiology -- 18. The electrocardiogram -- 19. Ambulatory electrocardiography -- 20. Tilt table testing -- 21. Electrophysiologic testing -- 22. Temporary transvenous pacing -- 23. Cardiac pacemakers -- 24. Biventricular pacing -- 25. Implantable cardioverter defibrillators (ICD) -- 26. Pacemakers interrogation and programming -- 27. Cardioversion and defibrillation -- Part IV. Interventional Cardiology -- 28. Coronary angiography -- 29. Coronary blood flow measurements -- 30. Percutaneous coronary intervention -- 31. Alcohol septal ablation -- 32. Transcatheter closure of atrial septal defects and patent foramen ovale -- 33. Balloon valvuloplasty -- 34. Transcatheter aortic valve replacement -- 35. Endomyocardial biopsy -- 36. Circlatory support devices -- Index.

This extensively revised edition is a single compact reference that describes a wide variety of diagnostic and therapeutic procedures performed by cardiologists. The focus is on the clinical application of these procedures with descriptions of their technical aspects, as well as contraindications and potential complications. The book provides detailed instruction on the interpretation of clinical data generated during these procedures and includes case presentations to illustrate how they are utilized in clinical practice. Cardiology Procedures: A Clinical Primer contains distilled clinical information and data important to those involved in the clinical care of cardiac patients. Comprising practical material designed to help in learning the diagnostic and therapeutic cardiology procedures performed in clinical practice, it will also be useful for trainees and practitioners in related disciplines.

Get quick answers to the most important clinical questions with Cardiology Secrets! Using the popular and trusted Secret Series Q&A format, this easy-to-read cardiology book provides rapid access to the practical, "in-the-trenches" know-how you need to succeed both in practice, and on cardiology board and recertification exams. Get the evidence-based guidance you need to provide optimal care for your patients with cardiac heart diseases.Explore effective solutions to a full range of clinical issues including the general examination, diagnostic procedures, arrhythmias, symptoms and disease states, valvular heart disease, cardiovascular pharmacology, and other medical conditions with associated cardiac involvement.Zero in on key information with bulleted lists, mnemonics, practical tips from the leading cardiologists, and "Key Points" boxes that provide a concise overview of important board-relevant content.Review essential material efficiently with the "Top 100 Secrets in Cardiology" - perfect for last-minute study or self-assessment.

Cardiovascular physical examination -- Heart murmurs and sounds -- Electrocardiography -- Chest x-ray -- Exercise stress testing -- Ambulatory electrocardiogram monitoring -- Echocardiography -- Nuclear cardiology -- Cardiac positron emission tomography -- Cardiac magnetic resonance imaging -- Cardiac computed tomography -- Swan-Ganz catheters and cardiac hemodynamics -- Coronary angiography and intracoronary imaging and physiologic assessment -- Chest pains and angina -- Chronic stable angina -- Non--ST-elevation acute coronary syndrome -- ST-elevation myocardial infarction -- Cardiogenic shock -- Percutaneous coronary intervention -- Coronary artery bypass surgery -- Myocarditis -- Dilated cardiomyopathy -- Heart failure with preserved ejection fraction -- Hypertrophic cardiomyopathy -- Restrictive cardiomyopathy -- Acute decompensated heart failure -- Heart failure : long-term management -- Heart transplantation -- Aortic stenosis -- Aortic regurgitation -- Mitral regurgitation -- Mitral stenosis -- Transcatheter aortic valve replacement -- Endocarditis and endocarditis prophylaxis -- Atrial fibrillation -- Supraventricular tachycardia -- Ventricular arrhythmias -- Cardiac pacing for bradycardia, heart block, and heart failure -- Implantable cardiac defibrillator -- Cardiac arrest and resuscitation -- Hypertension -- Hyperlipidemia -- Diabetes and cardiovascular disease -- Smoking cessation -- Physical activity, exercise, and the heart -- Cardiac manifestations of HIV/AIDS -- Cardiovascular complications of rheumatic diseases -- Cardio-oncology -- Cocaine and the heart -- Heart disease in the elderly -- Heart disease in pregnancy -- Heart disease in women -- Sleep apnea and the heart -- Peripheral arterial disease -- Aortic aneurysm -- Aortic dissection -- Carotid artery disease -- Ischemic stroke -- Hemorrhagic stroke and cerebral venous sinus thrombosis -- Deep vein thrombosis : prophylaxis and treatment -- Pulmonary embolism -- Hypercoagulable states -- Adult congenital heart disease -- Cardiac tumors -- Hypertensive crisis -- Oral anticoagulation therapy -- Pericarditis, pericardial constriction, and pericardial tamponade -- Preoperative cardiac evaluation -- Pulmonary hypertension -- Syncope -- Traumatic heart disease.

Cardiovascular physical examination -- Heart murmurs and sounds -- Electrocardiography -- Chest x-ray -- Exercise stress testing -- Ambulatory ECG monitors -- Echocardiography -- Nuclear cardiology -- Cardiac positron emission tomography -- Cardiac magnetic resonance imaging -- Cardiac computed tomography -- Bedside hemodynamic monitoring -- Cardiac catheterization: coronary angiogram, intracoronary imaging, and physiology -- Chest pains and angina -- Chronic stable angina -- Non-ST-elevation acute coronary syndrome -- ST-elevation myocardial infarction -- Cardiogenic shock -- Percutaneous coronary intervention -- Coronary artery bypass surgery -- Myocarditis -- LV dysfunction and dilated cardiomyopathy: etiologies and evaluation -- Heart failure with preserved ejection fraction -- Hypertrophic cardiomyopathy -- Restrictive cardiomyopathy -- Acute decompensated heart failure -- Heart failure: long-term management -- Heart transplantation -- Aortic stenosis -- Aortic regurgitation -- Mitral regurgitation -- Mitral stenosis -- Transcatheter aortic valve replacement -- Endocarditis and endocarditis prophylaxis -- Atrial fibrillation -- Supraventricular tachycardia -- Ventricular arrhythmias -- Cardiac pacing for bradycardia, conduction abnormalities, and heart failure -- Implantable cardioverter defibrillators -- Cardiac arrest and resuscitation -- Hypertension -- Hyperlipidemia -- Diabetes and cardiovascular disease -- Smoking cessation -- Physical activity, exercise, and the heart -- Cardiac manifestations of HIV -- Cardiac manifestations of rheumatologic disorders -- Cardio-oncology -- Cocaine and the heart -- Cardiovascular sequelae of COVID-19 -- Heart disease in the elderly -- Heart disease in pregnancy -- Heart disease in women -- Sleep apnea and the heart -- Peripheral arterial disease -- Aortic aneurysms -- Aortic dissection -- Carotid artery disease -- Ischemic stroke -- Hemorrhagic stroke and cerebral venous sinus thrombosis -- Deep vein thrombosis -- Pulmonary embolism -- Hypercoagulable states -- Adult congenital heart disease -- Cardiac tumors -- Hypertensive crisis -- Oral anticoagulation therapy -- Pericarditis, pericardial constriction, and pericardial tamponade -- Preoperative cardiac evaluation -- Pulmonary hypertension -- Syncope -- Traumatic heart disease.

This volume has been assembled for scientists interested in basic and applied biomedical research directed toward understanding the development, genetics, and function of cardiomyocytes. The methods and protocols contained within it address cell culture techniques, cardiomyocyte differentiation and redifferentiation, experimental induction of cardiomyopathies, introducing genes into cardiomyocytes, genomic approaches to the understanding cardiomyocytes, cryopreservation of neonatal cardiomyocytes, and modeling of cardiomyocyte function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and current, Cardiomyocytes: Methods and Protocols explores complimentary areas of cardiomyocyte science that, taken together, can inform individuals with a broad range of interests.

This book will provide readers with a detailed understanding of the ischemic damage to the myocardium after myocardial infarction, as well as essential tools for the treatment of damaged heart after myocardial infarction. It discusses various methods such as pharmacological pre- and post-conditioning, cytokine therapy, and cell therapy especially using Muse cells.The coverage of Muse cell therapy, which includes the latest work done by the author and his collaborators, is a unique feature of the book. Muse cells have self-renewability and have ability to differentiate into cells with the characteristics of all three germ layers from a single cell, while they are non-tumorigenic. It is the first book to feature the Muse cell therapy, which may offer the new promising therapeutic strategy for acute myocardial infarction. .

This book offers a comprehensive overview of the basic physiology of the cardiac and pulmonary systems, tools for cardiopulmonary monitoring, and related issues in the management of specific conditions. The volume is divided into three main parts. The first part examines the functional basis of normal and abnormal physiology, organized into cardiac and pulmonary units and followed by a combined interactive component. The next section discusses cardiopulmonary monitoring tools and variables and is also divided into cardiac (e.g, echocardiography, heart rate, cardiac output), pulmonary (e.g, lung volume, pleural pressure, electrical impedance tomography), and combined tools such as radiology/MRI and tissue perfusion tests. The third section concerns the management and application of specific clinical problems such as pulmonary hypertension, cardiac shunts, cardiogenic shock, and ECMO with an emphasis on the physiological basics. Cardiopulmonary Monitoring: Basic Physiology, Tools, and Bedside Management for the Critically Ill is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, critical care, emergency medicine, anesthesiology, and radiology.

This comprehensive manual reviews the management of cardiorenal syndrome in heart failure. Chapters are structured in a practically applicable and easy-to-follow format with realistic case vignettes and key clinical management questions and answers, followed by a brief discussion of underlying pathophysiological mechanisms of a patient with cardiorenal syndrome. Building from this case, key questions are posed that are relevant to the clinical management and then potential evidence-based treatment strategies are proposed. Topics covered include loop diuretic resistance in acute and chronic heart failure, abdominal congestion, low output failure and potential diuretic complications due to hyponatremia. Cardiorenal Syndrome in Heart Failure thoroughly reviews cardiorenal syndrome from the perspective of both the cardiologist and nephrologist. Its case-based approach makes it an ideal resource for both practising and trainee cardiology and nephrology practitioners.

This book examines the links between physical activity (PA), cardiorespiratory fitness (CRF), and cardiovascular and metabolic diseases. It presents an overview of the role of PA and CRF in the prevention and management of risk factors associated with cardiometabolic diseases such as hypertension, peripheral vascular disease, stroke, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, and atherosclerosis. In addition, it explores how these risks vary with different populations such as the elderly and people of various racial backgrounds. The book also highlights risks associated with exercise and presents a prescription for appropriate and efficacious exercise to minimize risk and maximize health benefits for the heart. Cardiorespiratory Fitness in Prevention and Management of Cardiometabolic Disease is an essential resource for physicians, exercise physiologists, medical students, residents, fellows, nurses, and researchers in cardiology, cardiorespiratory fitness, exercise science, health promotion and disease prevention, public health, and epidemiology.

Significant changes have taken place in the realm of cardiac, thoracic, and vascular surgery during the last five to ten years. Many new operative procedures have been developed which remain relatively unknown to cardiothoracic surgeons. This practical manual covers a wide variety of these new processes, several of which are interventions offered to cardiologists practicing in the field of electrophysiology who are unaware that these interventions exist and can help them in situations they cannot solve. It includes general practical techniques; cardiac, thoracic, and vascular surgery procedures; and advances in cardiology and electrophysiology. Throughout the book, illustrations accompany the technical descriptions and show in step-by-step detail how to perform the operations and various procedures using proper equipment. Cardiothoracic Surgical Procedures and Techniques: A Practical Manual is an essential resource for physicians and related professionals, residents, fellows, physician assistants (PA), and graduate students in cardiology, cardiac surgery, thoracic surgery, and vascular surgery.

This book offers readers a comprehensive introduction to the techniques and application of 3D printing in cardiovascular medicine. To do so, it addresses the history, concepts, and methods of 3D printing, choice of printing materials for clinical purposes, personalized planning of cardiac surgery and transcatheter interventions with patient-specific models, enhancement of patient-physician communication, simulation of endovascular procedures, and advances in 3D bio-printing. The book particularly focuses on the application of 3D printing to improve the efficacy and safety of cardiac interventions, and to promote the realization of precision medical care. The book gathers contributions by an international team of experts in the field of cardiovascular medicine, who combine the latest findings with their own practical experience in using 3D printing to support the diagnosis and treatment of a wide range of cardiovascular diseases. They present in-depth discussions in the fields of congenital heart disease, valvular disease, coronary artery disease, cardiomyopathy, left atrial appendage occlusion, cardiac tumors and vascular diseases.

Introduction -- Basic medical science -- Cardiovascular and pulmonary assessment -- Cardiovascular and pulmonary disease comorbidity -- Cardiovascular and pulmonary interventions -- Conclusion.

This book provides a balanced presentation of the fundamental principles of cardiovascular biomechanics research, as well as its valuable clinical applications. Pursuing an integrated approach at the interface of the life sciences, physics and engineering, it also includes extensive images to explain the concepts discussed. Cardiovascular biomechanics encompasses the relationship between the mechanics of the cardiovascular system and biological function in health and disease, and it is increasingly recognised that normal function and diseases involve a complex interplay between biology and mechanical forces. With a focus on explaining the underlying principles, this book examines the physiology and mechanics of circulation, mechanobiology and the biomechanics of different components of the cardiovascular system, in-vivo techniques, in-vitro techniques, and the medical applications of this research. Written for undergraduate and postgraduate students and including sample problems at the end of each chapter, this interdisciplinary text provides an essential introduction to the topic. It is also an ideal reference text for researchers and clinical practitioners, and will benefit a wide range of students and researchers including engineers, physicists, biologists and clinicians who are interested in the area of cardiovascular biomechanics.

The book systematically describes the clinical and scientific aspects of cardiovascular calcification. Chapters detail the mechanisms associated with arterial and valve calcification, relevant risk factors, pathophysiology and the latest therapeutic techniques. Recent diagnostic technological developments including how computed tomography (CT) scanning can be utilized along with Agatston score to quantify coronary arterial calcification when investigating whether a patient for sub-clinical atherosclerosis are covered. The correlation with the presence of arterial calcification and extent of coronary stenosis is also explored. Cardiovasular Calcification details relevant aspects of the basic science and reviews the latest pathological and therapeutic techniques used in treating patients with cardiovascular calcification. It is therefore an essential resource for practicing cardiologists, cardiac surgeons, vascular specialists and radiologists.

The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.

This book provides the most current overview of the evaluation and management of cardiovascular disease in people living with HIV/AIDS. The text assesses the risk factors associated with cardiovascular disease in HIV/AIDS patients and explores the most cutting edge ways to diagnose and treat the specific diseases that are most common for people living with HIV. This text takes a well-rounded, multidisciplinary approach that considers infectious disease and HIV specialists who may have little familiarity with the diagnosis and management of manifest CVD or risk factors as well as those in remote areas where providers may have little or no infrastructure to support optimal care for their patients. The text also serves cardiovascular specialists who may not have the expertise in HIV care to meet the unique needs of these patients. Cardiovascular Care for the Patient Living with HIV is the ultimate resource for not only all infectious disease and HIV specialists, but also for cardiologists, neurologists, vascular surgeons, general practitioners, nurse practitioners, physician?s assistants, and all other medical professionals who care for people living with HIV.

Reporting results of clinical trials for publication / Marcus Flather and Tobias Geisler -- The management of chronic coronary artery disease / Sabu Thomas and William E. Boden -- Acute coronary syndromes (ST elevation and non-ST-elevation) / Tobias Geisler, Deepak L. Bhatt, and Marcus Flather -- Heart failure / Chris O'Connor and Wendy G. Strough -- Atrial fibrillation / Chee W. Khoo and Gregory Y.H. Lip -- Electrophysiology and pacing / Sabine Ernst and Irina Horduna -- Percutaneous coronary intervention / Dharam J. Kumbhani and Deepak L. Bhatt -- Randomized controlled trials in cardiac surgery-is there any alternative? / Thanos Athanasiou, Amir Sepehripour, and John Pepper -- Adult congenital heart disease / Cary C. Ward, J. Kevin Harrison, and Tom Bashore -- Cardiac imaging / Aiden Abidov and Daniel S. Berman -- Prevention of cardiovascular disease / Alice J. Owen and Christopher M. Reid.

This book is the first comprehensive approach on COVID-19 cardiac complications, both during the acute phase as well as in the long-COVID period. It provides an up-to-date and highly illustrated summary of the biology of SARS-CoV-2, the course of COVID-19, risk factors that worsen the disease in COVID-19 patients, clinical features of COVID-19 patients, COVID-19 cardiological complications, treatment, and prevention methods, and long-term cardiological aspects of COVID-19. Chapters provide the reader with a contemporary perspective on the emerging links between COVID-19 and cardiovascular disease. In addition, this volume discusses the clinical implications and therapeutic goals in patients with COVID-19 and cardiac complications, as well as possible therapeutic options. It also offers clear recommendations on how to manage (both non- and pharmacologically) to avoid the increased number of COVID-19 related deaths due to CVD and its risk factors. Cardiovascular Complications of COVID-19 will be the primary resource for physicians, residents, fellows, and nursed and medical students in the fields of cardiology and COVID-19/infectious diseases as well as healthcare providers that initiate preventive activities and dedicated programs.

This book discusses the evidence behind the relationship between COVID-19 and heart disease based on emerging state-of-the-art data. The rapid and unexpected global spread of the COVID-19 has revealed proportional levels of cardiovascular and metabolic complications. A myriad of pathogenetic mechanisms has come to the surface. There is still much research required to define whether cardiovascular disease causes COVID-19 complications or that cardiovascular disease appears as a result of the infection and which mechanisms are responsible. With cardiovascular and metabolic diseases already at pandemic levels and expected to increase further, this book provides readers with an urgent and thorough analysis of this association. Cardiovascular Complications of COVID-19: Risk, Pathogenesis and Outcomes provides answers to the increasing numbers of questions related to heart disease in COVID-19, highlighting the association between these pandemics and including risk factors, mechanisms and how these may impact diverse patients populations. It describes how COVID-19 impacts older patients and those with metabolic illnesses such as obesity and diabetes mellitus, while providing an overview of the observed gender dichotomy among patients. It therefore represents an essential resource not only for all cardiovascular physicians but also for any healthcare professionals managing patients with these diseases or those exploring COVID-19.

The availability and diffusion of high-performance technologies has strengthened the role of CT angiography and MR angiography as simple, reliable techniques for the characterization and treatment planning of the principal diseases of the cardiovascular system, an understanding of which has become essential for all radiologists. The aim of this book is to provide concise but thorough information and guidance on the main methods and examination techniques used when performing high-quality CT angiography and MR angiography studies in a broad range of clinical settings. The lucid text is supported by a large number of case studies and is rich in advice on image interpretation and practical suggestions for the evaluation and reporting of the examinations. Importantly, a central feature is detailed comparison of the advantages and limitations of the two techniques in various diseases and vascular regions; the book will therefore enable both trainee and expert radiologists to understand their indications and to select the most appropriate technique in different contexts.

v. 1. 1960-1973.

The book discusses the impact of genetics, social determinants of health, the environment, and lifestyle in the burden of cardiometabolic conditions in African American and Hispanic/Latinx populations. It includes fully updated and revised chapters on genetics and CVD risk, epidemiology of cardiovascular health, cardiovascular imaging, dyslipidemias and other emerging risk factors, obesity and metabolic syndrome, heart failure, and genetic variations in CVD. Unique aspects within African American and Hispanic/Latinx populations are explored with suggested appropriate therapeutic interventions. New chapters focus on ASCVD risk assessment, emerging precision medicine concepts, the impact of diabetes, resilience and CVD survival, and lifestyle and dieting considerations. Written by a team of experts, the book examines the degree to which biomedical and scientific literature can clarify the impact of genetic variation and environment on cardiovascular disease. The Second Edition of Cardiovascular Disease in Racial and Ethnic Minority Populations is an essential resource for physicians, residents, fellows, and medical students in cardiology, internal medicine, family medicine, clinical lipidology, and epidemiology.

Introduction -- Epidemiology of Cardiovascular Disease and Depression -- The risk relationship between depression and CVD during aging -- Mechanisms linking depression to cardiovascular disease: what do epidemiological studies tell us? -- Anxiety and the effects on cardiovascular disease -- A Clinical Cardiology Perspective of Psychocardiology -- The validity of vascular depression as a diagnostic construct -- Mental stress-induced myocardial infarction -- Neuropsychological Impairment of Patients with Depression -- Neuroimaging of risk factors of depression and cardiovascular disease -- Heart Rate Variability, Affective Disorders and Health -- Arterial Stiffness in the depression and cardiovascular comorbidity -- Depression and markers of arteriosclerosis -- cross-sectional analyses of the baseline examination of the BiDirect Cohort study -- Metabolic-Inflammation Aspects of Depression and Cardiovascular Disease -- Genetic overlap between depression and cardiovascular disease -- Emotional word processing in cardiovascular disease, depression, and depression subtypes -- Nutrition and depression -- current evidence on the association of dietary patterns with depression and its subtypes -- Cardiometabolic Risk and Monitoring in Psychiatric Disorders -- Monitoring for metabolic dysfunction and cardiovascular disease in bipolar disorder: a shared illness process approach -- Assessment and Psychological interventions in depression comorbid with cardiovascular disease -- Moving beyond mood: is it time to recommend cognitive training for depression in older adults? -- The Internet and Mobile technology: a platform for behavior change and intervention in depression and CVDs -- Pharmacological treatment and prevention of cardiovascular diseases and depression comorbidity: understanding epidemiological, clinical trial evidence and the biological underpinnings -- Anti-inflammatory agents for the treatment of depression in the light of comorbid cardiovascular disease -- The use of complementary alternative and integrative medicine (CAIM) for treatment and prevention of late-life depression and cardiovascular disease -- An integrative psychosomatic approach to the treatment of to the treatment of patients with cardiovascular disease -- Prevention of CVD in depression -- Screening for depression in coronary heart disease: detection of early disease states.

v.1, Antiarrhythmic, antihypertensive, and lipid lowering drugs ; v.2, [beta]-adrenoceptor blocking drugs ; v.3, Antithrombotic drugs ; v.4, Antihypertensive drugs today.

This book proposes a novel learning approach that complements and augments the prevailing method of case-based learning. Learning these signs requires the application and integration of the fundamental skills of observation, palpation, percussion, and auscultation, and in more advanced cases, the use of maneuvers performed at the patient's bedside. The book provides a discussion of the utility of the signs and reviews the mechanism and pathophysiology of related cardiovascular diseases. Each chapter discusses eponymic signs for a variety of cardiovascular diseases such as atherosclerosis, heart failure, hypertension, venothromboembolism, ischemic heart disease, pericarditis, and peripheral vascular disease. Finding a particular sign during the physical examination enhances clinical suspicion for a specific cardiovascular disease, directing physicians to obtain more specific studies to confirm a diagnosis. This should lead to the delivery of more efficient care with the potential benefit of lowering health care costs. Cardiovascular Eponymic Signs: Diagnostic Skills Applied During the Physical Examination is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, primary care, and internal medicine.

This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions. Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.

A basic understanding of cardiovascular physiology is essential for optimal patient care. This practical book provides a concise tutorial of all the essential aspects of cardiovascular hemodynamics and the techniques used to assess cardiovascular performance. A high-yield reference, this book is replete with figures, tracings, tables, and clinical pearls that reinforce the basic tenets of hemodynamics. From identifying key findings of the patient history and physical exam to correlating hemodynamic tracings with acute clinical presentations, this book arms the reader with the tools necessary to handle any hemodynamic-related situation.

Intended for anyone involved in the day-to-day management of patients with hemodynamic derangements, this book reinforces the basic tenets of hemodynamics through the use of hemodynamic tracings and clinical correlation.

Basics of hemodynamics. Introduction to basic hemodynamic principles / James E Faber, George A Stouffer -- The nuts and bolts of right heart catheterization and PA catheter placement / Vickie Strang, George A Stouffer -- Normal hemodynamics / Alison Keenon, Eron D Crouch, James E Faber, George A Stouffer -- Arterial pressure / George A Stouffer -- The atrial waveform / David P McLaughlin, George A Stouffer -- Cardiac output / Frederick M Costello, George A Stouffer -- Detection, localization, and quantification of intracardiac shunts / Frederick M Costello, George A Stouffer -- Valvular heart disease. Aortic stenosis / David P McLaughlin, George A Stouffer -- Hemodynamics of transcatheter and surgical aortic valve replacement / John P Vavalle, Michael Yeung, Thomas G Caranasos, Cassandra J Ramm -- Mitral stenosis / Robert V Kelly, Chadwick Huggins, George A Stouffer -- Aortic regurgitation / George A Stouffer -- Mitral regurgitation / Robert V Kelly, Mauricio G Cohen, George A Stouffer -- The tricuspid valve / David A Tate, George A Stouffer -- Hemodynamic findings in pulmonic valve disease / Cynthia Zhou, Anand Shah, George A Stouffer -- Cardiomyopathies. Hypertrophic cardiomyopathy / Jayadeep S Varanasi, George A Stouffer -- Heart failure / Geoffrey T Jao, Steven Filby, Patricia P Chang -- Restrictive cardiomyopathy / David P McLaughlin, George A Stouffer -- Pericardial disease. Constrictive pericarditis / David P McLaughlin, George A Stouffer -- Cardiac tamponade / Siva B Mohan, George A Stouffer -- Effusive-constrictive pericarditis / Eric M Crespo, Sidney C Smith, George A Stouffer -- Hemodynamic support. Hemodynamics of intra-aortic balloon counterpulsation / Richard A Santa-Cruz, George A Stouffer -- Hemodynamics of left ventricular assist device implantation / Brett C Sheridan, Jason N Katz -- Coronary hemodynamics. Coronary hemodynamics / David P McLaughlin, Samuel S Wu, George A Stouffer -- Fractional flow reserve / Paul M Johnson, Shriti Mehta, Prashant Kaul, George A Stouffer -- Miscellaneous. Right ventricular myocardial infarction / Robert V Kelly, Mauricio G Cohen, George A Stouffer -- Pulmonary hypertension / Lisa J Rose-Jones, Daniel Fox, David P McLaughlin, George A Stouffer -- Hemodynamics of arrhythmias and pacemakers / Rodrigo Bolanos, Kimberly A Selzman, Lukas Jantac, George A Stouffer -- Systematic evaluation of hemodynamic tracings / George A Stouffer.

Part 1: Preclinical imaging of mechanisms of atherosclerosis and its complications -- Pathobiology and basic mechanisms of atherosclerosis -- Ultrasound imaging of endothelial cell activation and damage in atherosclerosis -- Molecular imaging of macrophages -- Optical molecular imaging of inflammation and calcification in atherosclerosis -- Imaging of antigen-presenting cells -- Imaging of oxidation-specific epitopes -- Intravascular molecular imaging -- Imaging of complications of atherosclerosis (platelets aggregation and thrombosis) -- Part 2: Imaging insights into mechanisms of calcific aortic valve disease (CAVD) and calcification -- Pathobiology and basic mechanisms of CAVD -- Molecular imaging of aortic valve inflammation and calcification: Preclinical studies -- PET CT imaging of inflammation and calcification in CAVD: Clinical studies -- Ultrasound imaging of CAVD -- Micro-OCT imaging of microcalcification -- Part 3: Clinical imaging of inflammation and calcification -- MR imaging in cardiovascular disease -- Molecular mechanisms of atherosclerosis imaged by MR -- Cardiovascular nuclear imaging -- Preclinical and clinical PET CT imaging of inflammation and calcification -- Clinical feasibility and monitoring of the effects of anti-inflammatory therapy in atherosclerosis.

Testosterone and cardiovascular risk in men / Kelly, D.M., Jones, T.H. -- Hormone therapy and venous thromboembolism among postmenopausal women / Scarabin, P.-Y. -- Cardiovascular and metabolic impact of glucocorticoid replacement therapy / Johannsson, G., Ragnarsson, O. -- Cardiovascular disease and thyroid function / Faber, J., Selmer, C. -- Hormonal alterations in heart failure : anabolic impairment in chronic heart failure -- diagnostic, prognostic and therapeutic issues / Arcopinto, M., Cittadini, A. -- Genetics of primary aldosteronism / Funder, J.W. -- Adipose tissue dysfunction and inflammation in cardiovascular disease / Wronkowitz, N., Romacho, T., Sell, H., Eckel, J. -- Potential peptides in atherosclerosis therapy / Marleau, S., Mellal, K., Huynh, D.N., Ong, H. -- Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging / Higashi, Y., Quevedo, H.C., Tiwari, S., Sukhanov, S., Shai, S.-Y., Anwar, A., Delafontaine, P. -- Ghrelin and the cardiovascular system / Tokudome, T., Kishimoto, I., Miyazato, M., Kangawa, K. -- Natriuretic peptide system and the heart / del Ry, S., Cabiati, M., Clerico, A. -- Beyond glycemic control : cardiovascular effects of incretin-based therapies / Angeli, F.S., Shannon, R.P.

Basic principles of cardiovascular magnetic resonance -- Techniques for T1, T2, and extracellular volume mapping -- Cardiovascular magnetic resonance contrast agents -- Myocardial perfusion imaging theory -- Myocardial perfusion cardiovascular magnetic resonance : advanced techniques -- Blood flow velocity assessment -- Use of navigator echoes in cardiovascular magnetic resonance and factors affecting their implementation -- Cardiovascular magnetic resonance assessment of myocardial oxygenation -- Cardiac magnetic resonance spectroscopy -- Special considerations for cardiovascular magnetic resonance : safety, electrocardiographic setup, monitoring, and contraindications -- Pacemaker and implantable cardioverter-defibrillator safety and safe scanning -- Special considerations : cardiovascular magnetic resonance in infants and children -- Human cardiac magnetic resonance at ultrahigh fields : technical innovations, early clinical applications and opportunities for discoveries -- Clinical cardiovascular magnetic resonance imaging techniques -- Normal cardiac anatomy -- Assessment of cardiac function -- Stress cardiovascular magnetic resonance : wall motion -- Stress cardiovascular magnetic resonance : clinical myocardial perfusion -- Acute myocardial infarction : cardiovascular magnetic resonance detection and characterization -- Acute myocardial infarction : ventricular remodeling -- Myocardial viability -- Cardiovascular magnetic resonance tagging for assessment of left ventricular diastolic function -- Magnetic resonance imaging of coronary arteries : technique -- Coronary artery imaging : clinical results -- Coronary artery and sinus velocity and flow -- Coronary artery bypass graft imaging and assessment of flow -- Atherosclerotic plaque imaging : aorta and carotid -- Atherosclerotic plaque imaging : coronaries -- Assessment of the biophysical mechanical properties of the arterial wall -- Valvular heart disease -- Role of cardiovascular magnetic resonance in dilated cardiomyopathy -- T1 and T2 mapping and extracellular volume in cardiomyopathy -- Cardiac iron loading and myocardial T2 -- Arrhythmogenic right ventricular cardiomyopathy -- Myocarditis -- Hypertrophic cardiomyopathy -- Cardiovascular magnetic resonance imaging in the evaluation of cardiac transplantation -- Cardiac and paracardiac masses -- Cardiovascular magnetic resonance assessment of right ventricular anatomy and function -- Simple and complex congenital heart disease : infants and children -- Simple and complex congenital heart disease : adults -- Pulmonary vein and left atrial imaging -- Thoracic aortic disease -- Cardiovascular magnetic resonance angiography : carotids, aorta, and peripheral vessels -- Pulmonary artery -- The pericardium : anatomy and spectrum of disease -- Interventional cardiovascular magnetic resonance -- Pediatric interventional cardiovascular magnetic resonance -- Cost-effectiveness analysis for cardiovascular magnetic resonance imaging -- Cardiac positron emission tomography/magnetic resonance -- Guidelines for cardiovascular magnetic resonance -- Noncardiac pathology -- CMR screening form: Beth Israel Deaconess Medical Center (BIDMC): CMR Center -- CMR sequence protocols in use (2018) at the Beth Israel Deaconess Medical Center (BIDMC): CMR Center -- Analogous CMR terminology used by various vendors.

The significantly updated second edition of this important work provides an up-to-date and comprehensive overview of cardiovascular magnetic resonance imaging (CMR), a rapidly evolving tool for diagnosis and intervention of cardiovascular disease. New and updated chapters focus on recent applications of CMR such as electrophysiological ablative treatment of arrhythmias, targeted molecular MRI, and T1 mapping methods. The book presents a state-of-the-art compilation of expert contributions to the field, each examining normal and pathologic anatomy of the cardiovascular system as assessed by magnetic resonance imaging. Functional techniques such as myocardial perfusion imaging and assessment of flow velocity are emphasized, along with the exciting areas of artherosclerosis plaque imaging and targeted MRI. This cutting-edge volume represents a multi-disciplinary approach to the field, with contributions from experts in cardiology, radiology, physics, engineering, physiology and biochemistry, and offers new directions in noninvasive imaging. The Second Edition of Cardiovascular Magnetic Resonance Imaging is an essential resource for cardiologists and radiologists striving to lead the way into the future of this important field.

"The field of cardiovascular medicine continues to rapidly evolve in both diagnostic and therapeutic arenas. Over the past decade, substantial advances have been made on many fronts including the development and utilization of techniques and devices for cardiovascular imaging, electrophysiology mapping and ablation techniques, heart failure diagnosis and management, percutaneous hemodynamic support, newer drug-eluting stents, drug coated balloons and structural heart endovascular techniques. Concurrent with advances in percutaneous techniques, cardiovascular surgery has also evolved with minimally invasive and robotic techniques"-- Provided by publisher.

This updated manual is a practical and compact introductory text to CMR. It includes a didactic overview of the physics of magnetic resonance imaging, cross-referencing consistently to the clinical chapters and describing the relationship between an understanding of basic MRI physics and producing better images. Building on the first edition, the authors review the practicalities of CMR from referral to screening, set-up of the study and reporting, including numerous tips and tricks on how the reader can improve the quality of their images. The book outlines the most commonly acquired image components used in CMR and details how CMR is used in clinical practice. It covers the most common referrals for CMR imaging in a structured way with imaging protocols and case examples for each indication. Throughout the book, the authors have used graphs and tables to highlight important learning aspects. The emphasis of each chapter is on providing practical, hands-on information, making this book a key resource for all training and certifying for the use of CMR. Cardiovascular MR Manual, 2e is of use to all clinicians working in cardiology or imaging for developing a general understanding of the diagnostic information that can be obtained from CMR, the indications for referral, and the contraindications and limitations of the technique.

History of OCT -- Physics of OCT -- Histology validation of OCT images -- Characterization of coronary plaques -- Basic interpretation skill -- Early stent evaluation -- Late stent changes -- Bioabsorbable stent -- Stent thrombosis -- Neoatherosclerosis -- Consensus document -- Future development. .

This heavily revised second edition comprehensively reviews the use of optical coherence tomography (OCT) in cardiovascular practice. It provides detailed guidance on how to properly interpret OCT images and successfully utilise it in daily clinical practice Chapters cover the development and physics associated with OCT, relevant interpretation skills, OCT imaging artifacts, plaque erosion, bioabsorbable stent, the detection of vulnerable plaque, and the use of OCT imaging in unison with other modalities such as phase contrast imaging (PCI). Areas of potential future development are also covered Cardiovascular OCT Imaging enables interventional cardiologists and cardiologists to quickly become both familiar and develop a detailed understanding of this technology to improve patient care and treatment outcome. It is a valuable reference for all practising and trainee medical professionals in cardiology, and in particular those who specialize in interventional cardiology.

Section 1: Current Concepts of Cardiovascular Pet Imaging: The New Paradigm Timothy M. Bateman -- Section 1: Current Concepts of Cardiovascular Pet Imaging: The New Paradigm: Introduction -- Section 2: Clinical Overview of Contemporary Myocardial Perfusion Imaging with Cardiac PET -- Chapter 1: Clinical Overview of Contemporary Myocardial Perfusion Imaging with Cardiac Positron Emission Tomography (PET) -- Chapter 2: Coronary Artery Calcium Scanning in Conjunction with Stress/Rest Myocardial Perfusion Imaging: Complementary Uses for Risk Assessment and Clinical Patient Management -- Chapter 3: Interpretation of Cardiac PET Myocardial Perfusion Imaging Studies -- Section 3: Quantitative Myocardial Blood Flow Assessment -- Chapter 4: Assessing Myocardial Blood Flow with Cardiac PET: Acquisition, Processing, and Quality Control -- Chapter 5: Quantitative Myocardial Blood Flow: Practical Clinical Perspective with Case Examples -- Section 4: Technical Developments in Cardiovascular PET -- Chapter 6: Latest Innovations in Cardiovascular PET Instrumentation -- Chapter 7: New Developments in Cardiac PET Radionuclide Production: Tracers, Cyclotrons, Generators, and Delivery Systems for Cardiac PET Imaging -- Chapter 8: Radiation Exposure with Cardiovascular PET: New Data -- Section 5: Myocardial Viability Assessment: The Current Role of Cardiac PET -- Chapter 9: Cardiac PET Myocardial Viability Assessment: Emerging Clinical Data -- Chapter 10: Patient Preparation for FDG PET Viability Imaging -- Chapter 11: Interpretation of Cardiac PET Myocardial Viability Studies -- Section 6: Current Status of Assessment of Cardiovascular Inflammation and Infection Imaging -- Chapter 12: Current Status of Assessment of Cardiac Sarcoid and Cardiac Amyloid with PET/CT Imaging -- Chapter 13: FDG PET/CT for Imaging Cardiovascular Device Infection.

Overview of the cardiovascular system -- Characteristics of cardiac muscle cells -- The heart pump -- Measurements of cardiac function -- Cardiac abnormalities -- The peripheral vascular system -- Vascular control -- Hemodynamic interactions -- Regulation of arterial pressure -- Cardiovascular responses to physiological stresses -- Cardiovascular function in pathological situations -- Answers to study questions.

Overview of the circulation and blood -- Excitation : the cardiac action potentia -- Automaticity : natural excitation of the heart -- The cardiac pump -- Regulation of the heartbeat -- Hemodynamics -- The arterial system -- The microcirculation and lymphatics -- The peripheral circulation and its control -- Control of cardiac output: coupling of heart and blood vessels -- Coronary circulation -- Special circulations -- Interplay of central and peripheral factors that control the circulation.

"This ninth edition includes some recent, new findings as well as a newly added emphasis on cardiovascular energetics. The latter is a result of our recent realization that maximizing energy efficiency to limit the workload on the heart is an important part of the overall plan."--Preface

"Gain a foundational understanding of cardiovascular physiology and how the cardiovascular system functions in health and disease. Cardiovascular Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the book"--Publisher's description.

Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanicastically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations, and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice. -- From publisher's description.

This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

This book is the first comprehensive text dedicated to risk assessment in the primary prevention of atherosclerotic cardiovascular disease. It provides an overview of current evidence regarding approaches to risk assessment, traditional and emerging risk factors, and atherosclerosis imaging for refinement of risk estimation. The volume seeks to provide an essential resource for professionals in the field to assess their patients for risk of cardiovascular disease. The book is divided into five sections, starting off with an overview of current best practices to risk assessment in primary prevention around the world. The second section discusses traditional risk factors, such as hypercholesterolemia, hypertension, diabetes, smoking, and obesity. The third section reviews the newly introduced concept of ‘Risk Enhancers’. The fourth section offers insight on novel risk factors, with in-depth discussion regarding lipoprotein(a), high-sensitivity CRP, apolipoprotein B, social determinants of health, stress and cardiovascular disease. and polygenic risk scores. The final section covers the use of non-invasive atherosclerosis imaging (computed tomography and ultrasound-based techniques) as a tool to refine risk estimates. Throughout the book, readers will find multiple tables, figures, and illustrations that complement the text. Up-to-date, evidence-based, and clinically oriented, Cardiovascular Risk Assessment in Primary Prevention is a must-have resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

The Central Importance of Cardiovascular Safety in Contemporary New Drug Development -- The Biological Basis of Drug Responses -- Cardiovascular Structure, Function, Pathophysiology, & Disease -- The Current Regulatory Landscape -- The "Comprehensive In Vitro Proarrhythmia Assay" Initiative -- The "Early ECG Assessment" Initiative -- The "Submission of Extended Digital ECG Data" Initiative -- Meta-analysis and Meta-methodology -- Current Regulatory Landscapes and their Potential Evolution -- Off-target Blood Pressure Responses to Non-cardiovascular Drugs -- Oncology Drug Development and Therapeutics: Cardiotoxicity Considerations -- Postmarketing Surveillance -- Regulatory Perspectives on General Drug Safety -- Future Directions in Cardiovascular Safety -- References.

v. 1. Circulation.

The Mothers meets An American Marriage in this dazzling debut novel about mothers and daughters, identity and family, and how the relationships that sustain you can also be the ones that consume you. The Butler family has had their share of trials, as sisters Althea, Viola, and Lillian can attest, but nothing prepared them for the literal trial that will upend their lives. Althea, the eldest sister and substitute matriarch, is a force to be reckoned with and her younger sisters have alternately appreciated and chafed at her strong will. They are as stunned as the rest of the small community when she and her husband Proctor are arrested, and in a heartbeat the family goes from one of the most respected in town to utter disgrace. The worst part is, not even her sisters are sure exactly what happened. As Althea awaits her fate, Lillian and Viola must come together in the house they grew up in to care for their sister's teenage daughters. What unfolds is a stunning portrait of the heart and core of an American family in a story that is as page-turning as it is important.

Care Coordination : A Blueprint for Action for RNs, [the sequel to the ANA's Care Coordination: the Game Changer] helps today's nurses reclaim this critical practice domain. It explores key issues in care coordination and offers timely, strategic actions nurses can take right now to identify opportunities and overcome barriers. It also includes critical resources for nurse care coordinators. This book will help you: Understand care coordination - past, present, and future - as well as the professional and practice environments in which it occurs; define the activities associated with effective care coordination; recognize the significant need for care coordination and opportunities for nurses Identify and explore issues pivotal to creating new inroads for nursing to adapt and advance this important work; expand the capacity of nurses to deliver care coordination and develop new and better care coordination models. Learn how you and your fellow nurses can advance your important role in care coordination in the current and emerging health care environment. -- Publisher's website.

As mental health is a critical but often neglected issue, especially among Black men, this book examines that sensitive topic in conjunction with reflections on race, gender, sexuality, and class to offer a hopeful and constructive framework for care and counseling and to point the way forward to integrating mental and spiritual health.

This book addresses the unique healthcare needs of adults with chronic childhood illnesses. It presents a model of primary and secondary prevention for emerging adulthood primary prevention in which all young adults are screened for high-risk behaviors and health needs and secondary prevention in which young adults with chronic childhood conditions are optimized through coordinated care, connections to community resources and social/family support. This book is organized in five parts. Part I provides a detailed overview of the health care transition from pediatrics to adult medicine from both a policy and practice perspective. In Part II, the concept of emerging adulthood as a developmental period is explored and strategies for providing improved comprehensive care for this age group are discussed. Part III reviews specific chronic childhood conditions, such as attention-deficit/hyperactivity disorder, autism, cystic fibrosis, and diabetes mellitus, and offers clinical cases and summary reports that can be used as a quick guides to each condition. In Part IV, additional clinical considerations that are not necessarily condition-specific but are highly relevant to the care of young adults with chronic childhood conditions are examined. Part V describes the socio-legal issues involved in caring for this population. Care of Adults with Chronic Childhood Conditions provides primary care providers with a new framework for the care of young adults and identifies opportunities to influence patient health outcomes over a life trajectory.

An introduction to military service -- Health consequences of military service and combat -- Understanding military families : their characteristics, strengths, and challenges -- Military children and programs that meet their needs -- Military health care system and the U.S. Department of Veterans Affairs : an overview -- Combat stress reactions and psychiatric disorders after deployment -- Substance use disorders -- The care of combat-injured service members -- Traumatic brain injury -- Suicidal thoughts and behaviors in military service members and veterans -- Collaborative care : mitigating stigma and other barriers to care through mental health service delivery in primary care settings -- Deployment-related care for military children and families -- Children and families of ill and injured service members and veterans -- Caring for bereaved military family members -- Building resilience in military families.

Society, madness, and control / Nikolas Rose -- UK health policy in relation to mentally disordered offenders in the community / Jane Senior, Adrian Hayes, and Jenny Shaw -- US outpatient commitment in context / Jeffrey W. Swanson, Marvin S. Swartz, and Daniel D. Moseley -- The law in England and Wales on mental health treatment in the community / Jo Beswick and Michael Gunn -- Achieving positive outcomes for justice-involved people with behavioral health disorders / David A. D'Amora, Mai P. Tran, and Fred C. Osher -- Psychiatric disorder and individual violence / Joan Busfield -- Recovery and recidivism reduction for offenders with mental illness / Merrill Rotter, Virginia Barber-Rioja, and Faith Schombs -- Treatment and management of personality-disordered offenders in the community / Nikki Jeffcote and Jackie Craissati -- Treatment with medication / Derek K. Tracy and Fiona Gaughran -- Outpatient psychotherapeutic approaches with mentally disordered offenders / Cleo Van Velsen and Kingsley Norton -- Sex offender treatment / John M.W. Bradford, Giovana V. de Amorim Levin, Adekunle G. Ahmed, and Sanjiv Gulati -- Violence risk in community settings / Alec Buchanan and Michael A. Norko -- Community psychiatric treatment under legal mandates / Alec Buchanan, Steve Kisely, Daniel D. Moseley, Jorun Rugkåsa, Jeffrey W. Swanson, and Marvin S. Swartz -- Lowering legal barriers to transitioning mentally disordered offenders into general mental health care / John Dawson and Tom Burns -- Multiple agencies with diverse goals / James McGuire and Lisa Wootton -- The community mental health team and the mentally disordered offender / Frank Holloway and Tony Davies -- The interface of general psychiatric and forensic psychiatric services / Lisa Wootton, Tom Fahy, Simon Wilson, and Alec Buchanan.

Follow-up to the Lambda Literary Award-winning anthology: The Remedy : new ways of imagining what LGBTQ+ health care could look like. The Care We Dream Of is not quite an essay collection, and not quite an anthology. It's a hybrid. What if you could trust in getting the health care you need in ways that felt good and helped you thrive? What if the health system honoured and valued queer and trans people's lives, bodies, and expertise? What if LGBTQ+ communities led and organized our own health care as a form of mutual aid? What if every aspect of our health care was rooted in a commitment to our healing, pleasure, and liberation? LGBTQ+ health care doesn't look like this today, but it could. This is the care we dream of. This book weaves together the author's essays on topics like queering health and healing, transforming the health system, kinship, aging, and death, alongside stories, poetry and non-fiction pieces by a diverse group of LGBTQ+ writers including Leah Lakshmi Piepzna-Samarasinha, Kai Cheng Thom, Jillian Christmas, jaye simpson, Carly Boyce, Sand Chang, Blyth Barnow and Joshua Wales. The book also includes interviews with activists, health care workers and researchers whose work offers insights into what liberatory and transformative approaches to LGBTQ+ health can look like in practice. The Care We Dream Of offers possibilities-- grounded in historical examples, present-day experiments, and dreams of the future-- for more liberatory and transformative approaches to LGBTQ+ health and healing. It challenges readers to think differently about LGBTQ+ health and asks what it would look like if our health care were rooted in a commitment to the flourishing and liberation of all LGBTQ+ people. This book is a calling out, a calling in, and a call to action. It is a spell of healing and tranformation, rooted in love.-- Provided by publisher.

SECTION I: CAREER PLANNING -- Career Options in Radiation Oncology -- Foundations for a Successful Career -- Approaching Your Academic Career -- Strategies for Applicants Belonging to Underrepresented Groups -- SECTION II: APPLYING TO FACULTY POSITIONS -- Informational Interviews / Interviewing for a Position -- Preparing your CV and Cover Letter -- Evaluating Your Contract/Medical Legal Considerations -- Changing Jobs -- SECTION III: EARLY CAREER DEVELOPMENT -- Identifying and utilizing mentors -- Conflict Resolution and Interpersonal Strategies -- Aligning Your Goals with Your Colleagues, Department, and Institution -- Working with Staff and Colleagues -- Becoming a Clinician: Organization, Interprofessional Considerations, Documentation, Billing, and Insurance -- Becoming an educator: giving feedback, supervising trainees, formal didactics -- Becoming a researcher: Grants & Budgets; Reviewing and Writing Papers; and the IRB -- Radiation Oncology Career development in an Academic Satellite Network -- When life happens: parental leave, part-time schedules and flexible workplace strategies -- SECTION IV: MID AND SENIOR CAREER -- Professionalism: Instincts Below the Surface and Environmental Influences -- Promotions -- Maintenance and Assessment of Skills and Knowledge Over the Career Continuum -- Networking -- Leadership versus Service: What's the Difference? Is There a Difference? -- Disease Site Leadership -- Role of the Department Chair -- Successful Strategies to Exploit the Intersection Between the Radiation Oncology Department and Cancer Center -- Business Development from Research, Entrepreneurship Within Academic Medicine -- An Approach to the Management of Selected Personnel and Ethical Problems in Academic Radiation Oncology -- Approaching strategic planning -- SECTION V: MISCELLANEOUS CONTEXT ISSUES -- Handling Burnout -- Preparing for retirement and career transitions -- Personal Finance and Work-Life Balance -- Paying it forward: being a good mentor, steward, and colleague.

Intentional sharing of knowledge & wisdom -- Preparation for knowledge & wisdom transfer -- Essential business knowledge -- Essential business relationships -- The art and science of knowledge & wisdom transfer -- Strategies for successful knowledge & wisdom transfer -- Lifelong learning and giving -- Leaving nursing better than you found it.

In providing a comprehensive overview of the career paths currently open to oral health professionals, this book will serve as an essential reference guide for anyone considering a career in oral health. It covers, for example, clinical career paths in general dentistry (in private practices, community centers, and hospitals) and each of the various specialties, academically related career paths in both teaching and research, and non-traditional paths (community, government, administration, policy making, government research, and oral health organizations). The authors are from various countries and both academic and non-academic backgrounds. They have been selected for their distinction in particular career paths and include in their contributions insights gained from personal experience. This book will be ideal for readers seeking an introductory portrait of the different career paths in oral health, such as students. It will also be a useful source for those wishing to re-examine the field, e.g., oral health graduates considering their career choices, or to acquaint themselves with contemporary issues and debates.

The transition from medical school to being a practicing junior doctor is challenging. It requires knowledge and clinical skills but also the ability to efficiently function in the workplace. At the same time postgraduate professional development in gaining clinical experience, passing postgraduate exams, under-taking research or audit, and publishing become essential for career progression. One soon realizes that being a doctor is not just a profession but a way of life. This book presents some well-known ℓ́ℓpearlsℓ́ℓ as how to improve your day to day workplace performance, be efficiently productive, be an inherent part of the team, how to shine and impress. Advice is also given as how to prepare for postgraduate exams, develop essential technical skills, apply for the next post, successfully participate in research and audit, publish, manage, lead, teach, and train. This generic guidance can be of use for those aspiring to become a generalist or subspecialty doctor and can be of value in whichever part of the world you end up practicing in.

This book presents various skills to help surgeons improve their day-to-day performance and development including professionalism, communication, situation awareness, decision making, leadership, and technical dexterity. It also offers advice on how to organise a surgical theatre list, improve theatre efficiency, prepare for surgical interviews and participate in surgical research and audit. Furthermore, it emphasises the need to strive for safety in surgery and to learn from things going wrong. The complex world of emotions that surgeons may encounter is also discussed. The guidance presented here may be of value to any aspiring surgeon, whatever their surgical specialty, and wherever they choose to practise. The skills highlighted in this book reflect the author's initial experiences as a surgical trainee, the teachings of his senior trainers, as well as his subsequent involvement in supervising multiple junior surgeons as a Consultant in Trauma and Orthopaedics. Much of the material presented is supported by an extensive literature review. This book complements the previously published book "Career Skills for Doctors" by the same author.

Pathophysiology of dental caries / G. Conrads, I. About -- Caries epidemiology and its challenges / J.E. Frencken -- Carious lesion diagnosis : methods, problems, thresholds / K.W. Neuhaus, A. Lussi -- Removing or controlling? how caries management impacts on the lifetime of teeth / F. Schwendicke, T. Lamont, N. Innes -- Restoring the carious lesion / G. Göstemeyer, F. Schwendicke, U. Blunck -- Removing carious tissue : why and how? / F. Schwendicke -- Stepwise excavation / L. Bjorndal -- Selective removal of carious tissue / D. Ricketts, N. Innes, F. Schwendicke -- Atraumatic restorative treatment : restorative component / S.C. Leal, C.C. Bonifacio, D.P. Raggio, J.E. Frencken -- Sealing carious tissue using resin and glass-ionomer cements / M. Fontana, N. Innes -- Sealing carious tissue in primary teeth using crowns / R.M. Santamaria, N. Innes -- No removal and inactivation of carious tissue : non-restorative cavity control / A.J.P. van Strijp, C. van Loveren -- Evidence-based deep carious lesion management : from concept to application in everyday clinical practice / S. Doméjean, B. Grosgogeat -- The problem : relevance, quality, and homogeneity of trial designs, outcomes, and reporting / G. Göstemeyer, C. Levey -- An agreed terminology for carious tissue removal / N. Innes, F. Schwendicke, J. Frencken -- Clinical recommendations on carious tissue removal in cavitated lesions / F. Schwendicke, J.E. Frencken, N.P.T. Innes -- Caries excavation : evidence gaps / N. Innes, M. Robertson, F. Schwendicke.

This book introduces readers to the basics of Advanced Practice Nursing (APN), which offers expanded clinical competence that can help improve the quality of health and care services. The book offers a range of perspectives on APN, APN models, APN education, challenges in the implementation of APN in new countries, as well as a description of the APN role, including areas of expertise. These core areas of the Caring APN model (clinical nursing practice; ethical decision-making; coaching and teaching; consultation; collaboration; case management; leadership; research and development) are described, together with the role of APN in acute care and primary healthcare service contexts. The book also explores the connection between epistemology, a three-dimensional view of knowledge (epistêmê, technê and phronesis) and a caritative perspective, as well as central theoretical aspects of nursing, e.g. health, holism and ethics/ethos. All research should be grounded in theoretical perspectives, and here we highlight the value of a caring and person-centered philosophy in advanced practice nursing. Through its specific focus on the central, generic theoretical features of nursing science that deepen the role of APN and the scope of practice and APN research and education, the content presented here will help any researcher, teacher or student understand the importance of epistemological issues for research, education and clinical practice in this field. Moreover, it can be used when designing Master's programs in Advanced Practice Nursing, making the book a valuable resource for the international nursing community.

Care for Children Born Small for Gestational Age is a comprehensive handbook that serves to synthesize the extensive recent literature in the area to provide a practical resource aimed at a wide range of healthcare professionals, including obstetricians, midwives, neonatologists, and primary care physicians. This comprehensive handbook includes an in-depth survey of the prevention, diagnosis, treatment and long-term monitoring of children born small for gestational age, as well as related conditions such as intrauterine growth restriction, metabolic syndrome and type 2 diabetes. Additionally, the short and long-term psychiatric and social consequences of this condition are addressed.

This volume provides a broad and critical presentation of the behavioral and psychosocial treatments of Latinxs with dementia in the United States (U.S.) and across a representative sample of Spanish-speaking countries in the world. The compendium of chapters, written by researchers, practitioners, and policy analysts from multiple disciplines provides a deep exploration of the current state of dementia care for Latinxs in the U.S. and around the globe. The volume is designed to increase and strengthen the collective scientific and sociocultural understanding of the epidemiological and biopsychosocial factors, as well as the overlapping systemic challenges that impact diagnosis and symptom management of Latinxs with dementia. The authors introduce policy options to reduce risk factors for dementia and present culturally-responsive interventions that meet the needs of Latinx patients and their caregivers. Highlighted topics featured in the book include: Contextual, cultural, and socio-political issues of Latinxs with dementia. New meta-analysis of dementia rates in the Americas and Caribbean. Dementia-related behavioral issues and placement considerations. Educational, diagnostic, and supportive psychosocial interventions. Pharmacological, non-pharmacological, and ethnocultural healthcare interventions. Intersectionality as a practice of dementia care for sexual and gender minoritized Latinxs. Prescriptions for policy and programs to empower older Latinxs and their families. Caring for Latinxs with Dementia in a Globalized World: Behavioral and Psychosocial Treatments is a resource thataccentuates and contextualizes the heterogeneity in nationality, immigration, race, sexual orientation, gender, and political realities. It is a key reference for a wide range of fields inclusive of demography, geriatrics, gerontology, medicine, mental health, neurology, neuropsychology, nursing, occupational therapy, pharmacology, psychiatry, psychology, rehabilitation, social work, sociology, and statistics all of which, collectively, bear on the problem and the solutions for better care for Latinxs affected by dementia.

The fourth edition contains guidelines on the development and evaluation of the health and safety of children in early care and education settings. This guide features 10 chapters of more than 650 standards and dozens of appendixes with valuable supplemental information, forms, and tools. -- Provided by publisher.

This book serves to educate and train primary care clinicians to provide high quality care to patients across the cancer care continuum. This guide is divided into six main chapters that follow the trajectory of cancer care: prevention, screening, diagnosis, treatment, survivorship care, and palliative/end-of-life care. Its succinct style, bullet points, tables and figures allow busy clinicians to both develop an overview of the core competencies involved in cancer care and quickly refer to the text in the process of caring for patients. Written by primary care physicians with expertise in cancer care, each chapter covers current recommendations and includes key points for select populations, considerations for the role of team based care, and resources for further learning. This is an ideal resource for primary care clinicians caring for patients along the cancer care continuum.

Provides healthcare workers with a frame of reference for understanding cultural difference and sound alternatives for providing the best possible care to multicultural communities.

Depression is the leading cause of disability in the United States, and the traditional framework for managing depression within a psychiatry practicei.e., a single psychiatrist treating a single patient for up to an hour per weekcomes up painfully short at the level of serving the population even if it can be highly effective for individuals. At the same time, the non-systematic way in which most patients identify the need to see a specialty provider in behavioral health leaves many stranded, regardless of how complex their needs are. Primary care is now often considered the "de facto mental health system" in the United States, and primary care providers have been charged with the impossible task of making up for the dearth of psychiatric specialty providers and somehow correcting the many inequities in access to care that remain. Primary care providers shouldnt have to do this alone. Help can come in many forms, of course, and some primary care practices are lucky enough to have a consulting psychiatrist on-site, available to answer any questions that come up and see patients directly when they need an expert opinion. This is exactly what David S Kroll, MD, an Associate Vice Chair in the Department of Psychiatry at Brigham and Womens Hospital in Boston and an Assistant Professor at Harvard Medical School, does for a primary care practice that serves more than 17,000 patients with a wide range of medical, social, and psychiatric problems. But most primary care practices dont have this resource. This book replicates the expertise of a consulting psychiatrist in a concise volume that primary care providers can pull off their shelves whenever they have a question about managing depression. It ensures that no one has to do this on their own. Managing Depression in Primary Care contains fourteen chapters that anticipate the questions, problems, and practical challenges that are most likely to come up when managing depression in primary care. It covers the basic skills that are needed for treating depression when it occurs in a vacuum, but it also provides practical guidance on treating depression in the real worldwhere it will inevitably be complicated by other factors. It also covers important associated topics including suicide, substance use, and disability.