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all 730 "T" titles


  • T cell protocols. 2nd ed. 2009
    Springer Protocols
    Analysis of frequency and phenotype of antigen-specific T cells / Angus Stock and Vincenzo Cerundolo -- B cell helper assays / Sergio Abrignani, ... [et al.] -- Transkingdom RNA interference (tkRNAi) / Thu A. Nguyen and Johannes H. Fruehauf -- Flow cytometry and cell activation / Sonia Gavasso -- Investigating T cells by polychromatic flow cytometry / Enrico Lugli, Leonarda Troiano, and Andrea Cossarizza -- Generation of human T cell clones / Sabrina Mariotti and Roberto Nisini -- Limiting dilution analysis of antigen-specific T cells / Jorge Carneiro, Lurdes Duarte, and Elisabetta Padovan -- T cell epitope-mapping by cytokine gene expression assay / Maurizio Provengano and Giulio C. Spagnoli -- Cytokine multiplex immunoassay / Wilco de Jager, Berent Prakken, and Ger T. Rijkers -- Purification of the T cell antigen receptor and analysis by blue-native PAGE / Mahima Swamy and Wolfgang W.A. Schamel -- Non-replicating recombinant vaccinia virus expressing CD80 to enhance T-cell stimulation / Paul Zajac.
  • Overview of orchestration of CD4+ T cell subsets in immune responses -- Th1/Th2 cell differentiation and molecular signals -- Th1/Th2 cell?s function in immune system -- Regulatory T Cell differentiation and their function in immune regulation -- Th17 differentiation and their pro-inflammation function -- Tfh Cell differentiation and their function in promoting B cell responses -- Differentiation, Regulation and Function of Th9 Cell -- The biology and functions of Th22 cell.
  • This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.
  • T-cell lymphomas 2013
    The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
  • Continuing the tradition of excellence that began in 1972, this latest edition of Tachdjian's Pediatric Orthopaedics offers the detailed visual guidance and unmatched expertise you need to effectively diagnose and treat pediatric musculoskeletal disorders. Extensive updates offer you the latest knowledge on etiology, imaging, differential diagnosis, and non-operative and surgical techniques for a wide range of pediatric orthopaedic conditions. Access expert guidance on difficult diagnostic and clinical management issues for your most challenging cases. Perfect your technique with the visual guidance of nearly 2,500 full-color illustrations and 60 videos of pediatric surgical procedures, including a number that highlight clinical examination and unusual clinical findings.
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  • Temporal characteristics of foot movement in tai chi exercise / Hong, Y., Mao, D.W., Lia, J.X. -- The exercise intensity of tai chi chuan / Lan, C., Chen, S.-Y., Lai, J.-S. -- Tai chi exercise and muscle strength and endurance in older people / Xu, D.Q., Hong, Y., Li, J.X. -- Muscle action pattern and knee extensor strength of older tai chi exercisers / Wu, G. -- The effectiveness of tai chi exercise in improving aerobic capacity : an updated meta-analysis / Taylor-Piliae, R.E. -- Tai chi exercise in improving cardiorespiratory capacity / Thornton, E.W. -- Effects of a traditional taiji/qigong curriculum on older adults' immune response to influenza vaccine / Yang, Y. ... [et al.] -- Tai chi exercise and proprioception behavior in old people / Li; J.X., Xu, D.Q., Hong, Y. -- Neural mechanisms underlying balance control in tai chi / Gatts, S. -- Sensorimotor control of balance : a tai chi solution for balance disorders in older subjects / Tsang, W.W.N., Hui-Chan, C.W.Y -- Tai chi and balance control / Wong, A.M.K., Lan, C. -- Tai chi and falls prevention in older people / Harmer, P.A., Li, F. -- Tai chi exercise and the improvement of mental and physical health among college students / Wang, Y.T. -- Effect of tai chi on depressive symptoms amongst Chinese older patients with major depression : the role of social support / Chou, K.-L. -- Tai chi exercise and the improvement of health and well-being in older adults / Yau, M.K.-s. -- Teaching tai chi with mindfulness-based stress reduction to middle school children in the inner-city : a review of the literature and approaches / Wall, R.B. -- Tai chi chuan in the management of Parkinson's disease and Alzheimer's disease / Klein, P.J. -- Tai chi training for patients with coronary heart disease / Lan, C. ... [et al.] -- Tai chi exercise in patients with chronic heart failure / Yeh, G.Y., Wayne, P.M., Phillips, R.S. -- Tai chi chuan for breast cancer survivors / Mustian, K.M., Palesh, O.G., Flecksteiner, S.A. -- Tai chi improves pain and functional status in adults with rheumatoid arthritis : results of a pilot single-blinded randomized controlled trial / Wang, C. -- Effects of tai chi exercise on patients with type 2 diabetes / Wang, J.H.
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  • A guide to the iPhone discusses the features of the device, including the iPhone media and the QWERTY keyboard, as well as its e-mail, voicemail, and calendar functions; Internet connectivity and applications; third-party software to enhance the iPhone; iTunes, iBooks, and iPhone games; power user applications; and accessories
  • Introduction : Finding a voice for the spirit -- Spirituality and the holistic approach -- Learning about spirituality in the multi-professional team -- Developing opportunities to talk about spirituality -- Understanding spirituality -- Spiritual care -- Outcomes and opportunities -- Conclusion : the journey continues.
  • Print Material
  • Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
  • Print Material
    Tandem repeat polymorphisms : mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility / Anthony J. Hannan -- Evolution of simple sequence repeats as mutable sites / David G. King -- Single amino acid and trinucleotide repeats : function and evolution / Noel Faux -- Promoter microsatellites as modulators of human gene expression / Sterling M. Sawaya ... [et al.] -- Dynamic mutations : where are they now? / Clare L. Van Eyk and Robert I. Richards -- Unstable mutations in the FMR1 gene and the phenotypes / Danuta Loesch and Randi Hagerman -- Molecular pathways to polyglutamine aggregation / Amy L. Robertson and Stephen P. Bottomley -- Polyglutamine aggregation in Huntington and related diseases / Saskia Polling, Andrew F. Hill and Danny M. Hatters -- Selective neurodegeneration, neuropathology and symptom profiles in Huntington's disease / Henry J. Waldvogel ... [et al.] -- Kennedy's disease : clinical significance of tandem repeats in the androgen receptor / Jeffrey D. Zajac and Mark Ng Tang Fui -- Characterising the neuropathology and neurobehavioural phenotype in Friedreich ataxia : a systematic review / Louise A. Corben ... [et al.] -- Polyalanine tract disorders and neurocognitive phenotypes / Cheryl Shoubridge and Jozef Gecz.
  • Longitudinal imaging and analysis of neurons expressing polyglutamine-expanded proteins / Andrey S. Tsvetkov, D. Michael Ando, and Steven Finkbeiner -- Atomic force microscopy assays for evaluating polyglutamine aggregation in solution and on surfaces / Kathleen A. Burke and Justin Legleiter -- Morphometric analysis of Huntington's disease neurodegeneration in Drosophila / Wan Song ... [et al.] -- Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge / Saskia Polling, Danny M. Hatters, and Yee-Foong Mok -- Method for the incremental expansion of polyglutamine repeats in recombinant proteins / Amy L. Robertson and Stephen P. Bottomley -- Pulse shape analysis (PulSA) to track protein translocalization in cells by flow cytometry : applications for polyglutamine aggregation / Yasmin M. Ramdzan, Rebecca Wood, and Danny M. Hatters -- Characterizing social behavior in genetically targeted mouse models of brain disorders / Emma L. Burrows and Anthony J. Hannan -- PCR amplification and sequence analysis of GC-rich sequences : aristaless-related homeobox example / May H. Tan, Jozef Gécz, and Cheryl Shoubridge -- Challenges of "Sticky" co-immunoprecipitation : polyalanine tract protein-protein interactions / T.R. Mattiske ... [et al.] -- Molecular pathology of polyalanine expansion disorders : new perspectives from mouse models / James N. Hughes and Paul Q. Thomas -- Yeast as a platform to explore polyglutamine toxicity and aggregation / Martin L. Duennwald -- Immuno-based detection assays to quantify distinct mutant huntingtin conformations in biological samples / Gregor P. Lotz and Andreas Weiss -- Modeling and analysis of repeat RNA toxicity in Drosophila / S.E. Samaraweera ... [et al.] -- Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis / Mats Holmberg and Ellen A.A. Nollen -- Kinetic analysis of aggregation data / Regina M. Murphy -- Bioinformatics method for identifying Q/N-rich prion-like domains in proteins / Eric D. Ross ... [et al.] -- Detecting soluble polyQ oligomers and investigating their impact on living cells using split-GFP / Patrick Lajoie and Erik Lee Snapp -- Cell biological approaches to investigate polyglutamine-expanded AR metabolism / Lori J. Cooper and Diane E. Merry.
  • v. 2 Springer Protocols
    v. 1. Emerging strategies for targets and biomarker discovery -- v. 2. Emerging molecular targets and treatment options.
  • Macrophage pattern recognition receptors in immunity, homeostasis, and self tolerance / Subhankar Mukhopadhyay, Annette Plüddemann, and Siamon Gordon -- Pattern recognition by toll-like receptors / Stefan Bauer, Thomas Müller, and Svetlana Hamm -- Nod-like receptors : pivotal guardians of the immunological integrity of barrier organs / Philip Rosenstiel and Stefan Schreiber -- Toll-like receptors and nod-like receptors : domain architecture and cellular signalling / Tanja Langefeld ... [et al.] -- Humoral pattern recognition molecules : mannan-binding lectin and ficolins / Steffen Thiel and Mihaela Gadjeva -- Lung surfactant proteins A and D as pattern recognition proteins / Patrick Waters ... [et al.] -- Pattern recognition by pentraxins / Alok Agrawal ... [et al.] -- Target pattern recognition by complement proteins of the classical and alternative pathways / Yu-hoi Kang ... [et al.] -- Pattern recognition in phagocytic clearance of altered self / Yoshinobu Nakanishi, Peter M. Henson and Akiko Shiratsuchi -- Structural basis of pattern recognition by innate immune molecules / Eamon P. McGreal -- Lessons from the fly : pattern recognition in Drosophila melanogaster / Subhamoy Pal and Louisa P. Wu -- Immune recognition of plasmodium-infected erythrocytes / Damien V. Cordery and Britta C. Urban -- Innate immune recognition in tuberculosis infection / Anthony G. Tsolaki.
  • The main objective of this book is to provide radiation oncologists with a clear, up-to-date guide to tumor delineation and contouring of organs at risk. With this in mind, a detailed overview of recent advances in imaging for radiation treatment planning is presented. Novel concepts for target volume delineation are explained, taking into account the innovations in imaging technology. Special attention is paid to the role of the newer imaging modalities, such as positron emission tomography and diffusion and perfusion magnetic resonance imaging. All of the most important tumor entities treated with radiation therapy are covered in the book. Each chapter is devoted to a particular tumor type and has been written by a recognized expert in that topic.
  • This handbook is designed to enable radiation oncologists to appropriately and confidently delineate tumor volumes/fields for conformal radiation therapy, including intensity-modulated radiation therapy (IMRT), in patients with commonly encountered cancers.The orientation of this handbook is entirely practical, in that the focus is on the illustration of clinical target volume (CTV) delineation for each major malignancy. Each chapter provides guidelines and concise knowledge on CTV selection for a particular disease, explains how the anatomy of lymphatic drainage shapes the selection of the target volume, and presents detailed illustrations of volumes, slice by slice, on planning CT images. While the emphasis is on target volume delineation for three-dimensional conformal therapy and IMRT, information is also provided on conventional radiation therapy field setup and planning for certain malignancies for which IMRT is not currently suitable.
  • This textbook is designed to help the busy radiation oncologist to accurately and confidently delineate tumor volumes for conformal radiation therapy (including IMRT). The book provides an atlas of clinical target volumes (CTVs) for commonly encountered cancers, with each chapter illustrating CTV delineation on a slice-by-slice basis, on planning CT images. Common anatomic variants for each tumor are represented in individual illustrations, with annotations highlighting differences in coverage. The anatomy of each site and patterns of lymphatic drainage are discussed, and their influence on the design of CTVs is explained in detail. Utilization of other imaging modalities, including MRI, to delineate volumes is highlighted. Key details of simulation and planning are briefly reviewed. Although the emphasis is on target volume delineation for conformal techniques, information is also provided on conventional radiation field setup and design when IMRT is not suitable.
  • Perspectives : bench to bedside and back / Jennifer Wheler and Razelle Kurzrock -- Targeted therapy in acute myelogenous leukemia / Elihu Estey -- Targeted therapy in breast cancer / Barbara S. Craft and Stacy Moulder -- Targeted therapy in chronic lymphocytic leukemia / Apostolia-Maria Tsimberidou and Michael J. Keating -- Targeted therapy in chronic myeloid leukemia / Elias Jabbour, Jorge Cortes, and Hagop Kantarjian -- Targeted therapy in colorectal cancer / Scott Kopetz -- Targeted therapy in non-small cell lung cancer / David J. Stewart -- Targeted therapy in lymphoma / Amanda Wedgwood and Anas Younes -- Targeted therapy in melanoma / Michael Davies, Sunil Patel, and Kevin B. Kim -- Targeted therapy in multiple myeloma / Yuhong Zhou, Raymond Alexanian, and Micael Wang -- Targeted therapy in myelodysplastic syndrome / Alfonso Quintás-Cardama ... [et al.] -- Targeted therapy in epithelial ovarian cancer / Maurie Markman -- Targeted drug therapy in pancreatic cancer / Don L. Gibbons, Robert A. Wolff, and Gauri Varadhachary -- Targeted therapy in prostate cancer / Amado J. Zurita, John F. Ward, and Jeri Kim -- Targeted therapy in renal cell carcinoma / Eric Jonasch and Nizar Tannir -- Targeted therapy of Sarcoma / Joseph Ludwig and Jonathan C. Trent -- Targeted and functional imaging / Vikas Kundra, Dawid Schellingerhout, and Edward F. Jackson -- Combining targeted therapies / David Hong and Lakshmi Chintala -- Drug development in cancer medicine : challenges for targeted approaches / Luis H. Camacho -- Toward personalized therapy for cancer / Sarah J. Welsh and Garth Powis.
  • Therapeutic potential of targeted drug delivery / Ajit S. Narang and Ram I. Mahato -- Antibody therapies for liver malignancy and transplantation / John M. Luk and Kwong-Fai Wong -- Transferrin receptor-mediated transcytosis in intestinal epithelial cells for gastrointestinal absorption of protein drugs / Nurmamet Amet ... [et al.] -- Ionizing radiation for tumor targeted drug delivery / Roberto Diaz, Li Zhou, and Dennis E. Hallahan -- Recent advances in gene expression and delivery systems / Ravikiran Panakanti and Ram I. Mahato -- Cellular barriers for nucleic acid delivery and targeting / Arto Urtti -- Targeted delivery systems of non-viral nucleic acid-based therapeutics / Ga Yong Shim ... [et al.] -- Delivery and targeting of oligonucleotides and siRNA / Ningning Yang and Ram I. Mahato -- Liposomes for non-viral gene delivery / Jiasheng Tu ... [et al.] -- Delivering the bullet to the right intracellular target : a cellular perspective on drug delivery / Maria Teresa Tarragâo-Trani and Brian Storrie -- Mitochondria-targeted drug delivery / Volkmar Weissig and Gerard G. M. D'Souza -- Site-specific prodrug activation strategies for targeted drug action / Mark D. Erion -- Enzyme-activated prodrug strategies for targeted drug action / Jarkko Rautio ... [et al.] -- Targeting colon and kidney : pathophysiological determinants of design strategy / Ajit S. Narang and Ram I. Mahato -- Principles and practice of pulmonary drug delivery / Vivek Gupta, Chandan Thomas, and Fakhrul Ahsan -- Recent advances in ocular drug delivery : role of transporters, receptors, and nanocarriers / Gyan P. Mishra ... [et al.] -- Injectable polymers for regional drug delivery / Rajendra P. Pawar ... [et al.] -- Polymer-drug conjugates / Lucienne Juillerat-Jeanneret and Feride Cengelli -- Polymer micelles for drug delivery / Sungwon Kim and Kinam Park -- Multifunctional stimuli-responsive nanoparticles for targeted delivery of small and macromolecular therapeutics / Srinivas Ganta, Arun Iyer, and Mansoor Amiji -- Physiological stress responsive gene regulation systems for tissue targeting / Hyun Ah Kim and Minhyung Lee.
  • Introduction: the rationale for the development of targeted drugs in cancer therapy -- Identifying critical signaling molecules for the treatment of cancer -- Tyrosine kinase inhibitors and cancer therapy -- Targeting ERBB receptors in cancer -- Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal anitbodies as alternative approaches -- Inhibition of the TGF-B signaling pathway in tumor cells -- The mammalian target of rapamycin kinase and tumor growth inhibtition -- The ras signalling pathway as a target in cancer therapy -- The mitogen-activated protein kinase pathway for molecular-targeted cancer treatment -- Clinical relevance of tareted interference with Src-mediated signal transduction events.
  • Targeted intraoperative radiotherapy is a major advance in the management of cancer patients and has been attracting massive interest worldwide following publication of the results of an important randomized controlled trial in The Lancet. This textbook is designed to introduce this innovative technology in a comprehensive manner to clinicians dealing with cancer patients. Throughout, the emphasis is on practical aspects, and the text is supported by many excellent illustrations. The editors of the book have extensive experience in targeted intraoperative radiotherapy and include co-directors of the TARGIT Academy, which runs international training courses on the technology in the United Kingdom and Germany. They have brought together multidisciplinary contributors from different centers across the world who have wide experience in the field and whose work has been recognized internationally. It is the editors' hope that this book will succeed in ensuring that targeted intraoperative radiotherapy is used effectively worldwide.
  • "Covering the fundamental concepts of molecular imaging, this work addresses basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery. Topics are presented in logical progression, from basic concepts to applications. The text includes examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases. The book is a valuable tool for readers involved with molecular imaging, biomedical imaging, radiology, medical physics, medicinal chemistry, and pharmacology"--Provided by publisher.
  • "This reference covers clinical and bioengineering aspects of muscle reinnervation, a popular new technique at the boundary of biomedical and rehabilitation engineering and neuroscience. With contributions from pioneers in the field, the book provides a review of muscle reinnervation from a biomedical engineering and clinical perspective. It describes neuroscience and other related neuroprosthetic techniques. A companion website offers a wide range of videos and multimedia material to aid in comprehension and application"--Provided by publisher.
  • Targeted therapies for hepatocellular carcinoma / Luigi Bolondi -- Overview of HCC pathophysiology and drug targets / Liliana Montella & Raffaele Addeo -- Antiangiogenic strategies for the treatment of hepatocellular carcinoma / Chiun Hsu, Ying-Chun Shen & Ann-Lii Cheng -- EGF receptor inhibitors for hepatocellular carcinoma / George Papatsimbas, Christina Chatedaki & Dimitris Zacharoulis -- mTOR inhibitors / Gerhard Treiber & Thomas Wex -- Histone deacetylase inhibitors (epigenetic alterations) / Sergio Valente & Antonello Mai -- Hepatocellular carcinoma therapy : combination is the future / Jean-François Dufour -- Other new targeted therapies / Jairo A. Garcia & Lewis R. Roberts.
  • Targeted therapy for non-small-cell lung cancer / Arun Rajan & Giuseppe Giaccone -- Overview of pathophysiology and drug targets for non-small-cell lung cancer / Anish Thomas, Arun Rajan & Giuseppe Giaccone -- EGFR inhibitors and their use in the treatment of metastatic disease / Cesare Gridelli & Antonio Rossi -- VEGF receptor inhibitors / Ariel Lopez-Chavez & Alan Sandler -- CTLA-4 inhibitor : ipilimumab for the treatment of NSCLC / Julie R. Brahmer -- VEGF receptor inhibitors / Kavitha Ramchandran, Millie Das & Heather Wakelee -- HGFR/MET and ALK inhibitors / Eunice L. Kwak -- Vaccines for lung cancer / Ronan J. Kelly -- Index.
  • Targeted therapy for renal cell carcinoma / Ronald M. Bukowski -- Overview of renal cell carcinoma pathways and drug targets / Bernard Escudier -- mTOR in renal cell cancer: modulator of tumor biology and therapeutic target / Piotr J. Wysocki -- VEGF inhibitors / Toni K. Choueiri & Ali R. Golshayan -- VEGFR/PDGFR inhibitors in RCC / Jean S.Z. Lee & Tim Eisen -- Next-generation immunotherapy: CTLA-4 and PD-1 inhibitors / Daniel Y.C. Heng -- EGF receptor inhibitors / Marine Gross-Goupil & Alain Ravaud -- Cytokines / Alexandra Leary, James M.G. Larkin & Lisa M. Pickering -- Vaccination / Robert J Amato -- Evidence-based therapy of non-clear-cell and sarcomatoid renal cell carcinoma / Elan Diamond, Naveed H. Akhtar, Scott T. Tagawa & David M. Nanus -- Bisphosphonates in renal cell carcinoma: palliation versus antitumor effects / Saby George & Roberto Pili -- Combination therapy and future directions in renal cell carcinoma / Bernard Escudier & Camillo Porta.
  • This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
  • Resistance to Targeted Therapies As a Result of Mutation(s) in the Target / Alexis B. Cortot and Pasi A. Jänne -- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies / Daniel Gioeli -- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry / Jason R. Neil and Forest M. White -- Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications / Julia D. Wulfkuhle, Menawar Khalil, Joseph C. Watson, Lance A. Liotta and Emanuel F. Petricoin -- Using Phosphoflow® to Study Signaling Events of Subpopulations Resistant to Current Therapies / Omar D. Perez -- Mathematical and Computational Models in Cancer / Sudhir Chowbina, Kevin A. Janes, Shayn M. Peirce and Jason A. Papin -- Somatic Evolution of Acquired Drug Resistance in Cancer / John W. Pepper -- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer / Edward Gunther -- microRNA: A Potential Therapy Able to Target Multiple Cancer Pathways / Benjamin Kefas and Benjamin W. Purow -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance / Yun Dai and Steven Grant.
  • This book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. The chapter topics include the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53, and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. In addition, chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells, and leukemia metabolism, provide insight into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies complete the overview of the multi-dimensional therapeutic landscape, where leukemia specialists develop treatment strategies, which are expected to bring forth critical breakthroughs in the field of leukemia.
  • Michael H. Weisman, Michael Weinblatt, James S Louie, and Ronald Van Vollenhoven offer their unique insights into choosing the correct pharmacological and non-pharmacological therapies for your patients. Chapters cover the full breadth of rheumatic diseases, rheumatoid arthritis, lupus, connective tissue diseases, osteoporosis, regional pain disorders, and fibromyalgia. The full-color design presents detailed clinical photographs and treatment algorithms for visual guidance and easy reference. Covers the treatment of pediatric patients as well as adults so that you can properly address the particular needs of any patient you see. Features the guidance and specific recommendations of experts from United States and Europe for a state-of-the-art approach to the variety of treatments currently in use. Displays the clinical manifestations of rheumatic diseases in full color, along with treatment algorithms for easy at-a-glance reference.
  • Conducted electrical weapons: a user's perspective / Greg Meyer -- The scientific history / Robert A. Stratbucker -- Conducted electrical weapons and resolution of use-of-force encounters / Charles Mesloh, Mark Henych, and Ross Wolf -- Nonlethal weapons: the broader context / Peter J. Cuenca and John G. McManus -- Transcutaneous muscle stimulation / James D. Sweeney -- Current flow in the human body / Dorin Panescu and Robert A. Stratbucker -- Animal studies / John G. Webster -- CEW research models: animal and human studies / Theodore C. Chan and Gary M. Vilke -- Cardiac arrhythmias / Derek J. Dosdall and Raymond E. Ideker -- Electrocardiographic effects of the CEW / Jeffrey D. Ho -- Serum and skin effects of CEW application / Jeffrey D. Ho -- Electrocardiographic effects of the CEW / Robert Reardon -- Rhabdomyolysis / Ronald Moscati and Samuel Cloud -- Effects of CEWs on respiration / Donald M. Dawes -- Neuroendocrine effects of CEWs / Donald M. Dawes and Mark W. Kroll -- Electroporation of cardiac and nerve cells / Vadim V. Fedorov, Leonid Livshitz, Geran Kostecki, and Igor R. Efimov -- Eye and head injuries / S. Robert Witherspoon, Andreas K. Lauer, and Jonathan L. Marinaro -- CEW effects with illegal stimulant intoxication / Patrick Tchou -- Alcohol and the CEW / Ronald Moscati and Jeffrey D. Ho -- Conducted electrical weapons and implantible cardiac devices / Subba Reddy Vanga, James L. Vacek. Loren Berenhom and Dhanunjaya R. Lakkireddy -- Risk management and the CEW / Greg Bingham -- The New York City experience / Michael D. White and Justin Ready -- Impact of CEW and other types of force and resistance on officer and suspect injuries / Michael R. Smith, Robert J. Kaminski, Jeffrey Rojek, Geoffrey P. Alpert, and James Mathis -- Field statistics overview / James E. Brewer and Mark W. Kroll -- Sudden in-custody death / Samuel J. Stratton -- Stimulant abuse and sudden cardiac death / Steven B. Karch -- The systemic role of illicit drugs and their toxicology / Joshua Gunn, Michael A. Evans, and M. Scott Kriger -- Excited delirium syndrome / Vincent J. M. Di Maio and Theresa G. Di Maio -- Biochemical brain markers in excited delirium deaths / Deborah C. Mash -- Sudden unexpected death in custody (SUDIC) / Charles V. Wetli -- Legal basics for the CEW -- Science and logic meet the law / Michael A. Brave -- Appendix A: Excited delirium checklist -- Appendix B: Electrocution diagnosis checklist.
  • Central gustatory processing in humans / Small, D.M. -- Modern psychophysics and the assessment of human oral sensation / Snyder, D.J., Prescott, J., Bartoshuk, L.M. -- Postoperative/posttraumatic gustatory dysfunction / Landis, B.N., Lacroix, J.-S. -- Neurological causes of taste disorders / Heckmann, J.G., Lang, C.J.G. -- Toxic effects on gustatory function / Reiter, E.R., DiNardo, L.J., Costanzo, R.M. -- Burning mouth syndrome / Grushka, M., Ching, V., Epstein, J. Nasal anatomy and the sense of smell / Hornung, D.E. -- Transduction and coding / Rawson, N.E., Yee, K.K. -- Smell: central olfactory processing / Gottfried, J.A. -- Structure and function of the vomeronasal organ / Witt, M., Wozniak, W. -- Assessment of olfactory function / Hummel, T., Welge-Lüssen, A. -- Posttraumatic olfactory loss / Costanzo, R.M.C., Miwa, T.M. -- Chronic rhinosinusitis and olfactory dysfunction / Raviv, J.R., Kern, R.C. -- Olfactory disorders following upper respiratory tract infections / Welge-Lüssen, A., Wolfensberger, M. -- Olfaction in neurodegenerative disorder / Hawkes, C. -- Human taste: peripheral anatomy, taste transduction, and coding / Breslin, P.A.S., Huang, L. --
  • Preface -- The tattooed and the social environment. The cultural heritage of tattooing: a brief history -- Epidemiology of tattoos in industrialized countries -- The practise of tattooing. Tattoo machines, needles and utilities -- The technique and craftsmanship of tattooing in the professional tattoo parlour -- Tattoo as art, the drivers behind the fascination and the decision to become tattooed -- Personal records from my tattoo parlour: deep emotions drawn as life-long pictures on the skin's canvas -- Tattooist-customer relationships in a diversified environment of professional tattooists and 'scratchers' -- Tattoos and adverse events. Tattoo complaints and complications: diagnosis and clinical spectrum -- Complications of cosmetic tattoos -- Chronic tattoo reactions cause reduced quality of life equaling cumbersome skin diseases -- Contraindications for tattooing -- Laser tattoo removal, precautions, and unwanted effects -- Nano-scale observations of tattoo pigments in skin by atomic force microscopy -- Manufacturing, materials and properties of marketed tattoo ink stock products. Manufacturing of tattoo ink products today and in future -- The realistic variables underlying true safety in tattoo pigment manufacturing -- Making innovative tattoo ink products with improved safety: possible and impossible ingredients in practical usage -- Tailored surface engineering of pigments by layer-by-layer coating -- Ingredients, chemical analysis and safety of marketed tattoo ink stock products. Chemical purity and toxicology of pigments used in tattoo inks -- Survey on european studies of the chemical characterisation of tattoo ink products and the measurement of potentially harmful ingredients -- Tattoo inks: legislation, pigments, metals and chemical analysis -- The challenges and limitations of chemical analysis of particulate pigments of very low solubility -- Photostability and breakdown products of pigments currently used in tattoo inks -- Carbon black nanoparticles and other problematic constituents of black ink and their potential to harm tattooed humans -- Absorption, distribution, metabolism and excretion of tattoo colorants and ingredients in mouse and man: the known and the unknown -- Towards the limiting of health risks associated with tattooing: whitelists for tattoo pigments and preservatives -- Survey of studies on microbial contamination of marketed tattoo inks -- Regulation of and intervention in the tattoo business. The European landscape of national regulations of tattoo inks and businesses -- Implementation of European Council Resolution ResAP(2008)1 in Italy. National and regional regulation of tattoo practices: diversity and challenges -- EU actions to ensure the safety of tattoos and the protection of consumers -- Surveillance of tattoo-related adverse events by the EU RAPEX System and by national monitoring -- The Amsterdam model for control of tattoo parlours and businesses -- Hygiene standards for tattooists -- Hygiene standards in the tattoo parlour and practices for prevention of infection -- Seamless prevention of adverse events from tattooing: integrated strategy emphasising the customer-tattooist interaction -- Regulation of tattoo ink production and the tattoo business.
  • Taurine 9 2015
    Taurine 9 contains original articles and critical reviews based on the oral and poster presentations of XIX International Taurine Meeting held in Kraków, Poland in May 2014. The purpose of the book is to present current ideas, new avenues and research regarding biological functions and clinical applications of taurine and taurine derivatives. It focuses on all aspects of taurine research including the cardiovascular system, the immune system, diabetes, the central nervous system, endocrine system and the role of taurine supplements in nutrition. It also includes presentations of novel animal experimental models using Cdo1 and CSAD knock-out mice.
  • Taurine. 6 2006
  • Taurine. 7 2009
  • Taurine. 8 v. 1-2, 2013.
    v.2 Springer
    Volume 1. The Nervous system, immune system, diabetes and the cardiovascular system -- Volume 2. Nutrition and metabolism, protective role, and role in reproduction, development, and differientiation.
  • Pt. I. Principles of taxonomy. The magnitude and diversity of infectious diseases -- What is a classification? -- The tree of life -- pt. II. Bacteria. Overview of Class Bacteria -- The Alpha Proteobacteria -- Beta Proteobacteria -- Gamma Proteobacteria -- Epsilon Proteobacteria -- Spirochaetes -- Bacteroidetes and Fusobacteria -- Mollicutes -- Class Bacilli plus Class Clostridia -- Chlamydiae -- Actinobacteria -- pt. III. Eukaryotes. Overview of Class Eukaryota -- Metamonada -- Euglenozoa -- Percolozoa -- Apicomplexa -- Ciliophora (ciliates) -- Heterokontophyta -- Amoebozoa -- Choanozoa -- Archaeplastida -- pt. IV. Animals. Overview of Class Animalia -- Platyhelminthes (flatworms) -- Nematoda (roundworms) -- Acanthocephala -- Chelicerata -- Hexapoda -- Crustacea -- Craniata -- pt. V. Fungi. Overview of Class Fungi -- Zygomycota -- Basidiomycota -- Ascomycota -- Microsporidia -- pt. VI. Nonliving infectious agents : viruses and prions. Overview of viruses -- Group I viruses : double-stranded DNA -- Group II viruses : single-stranded (+)sense DNA -- Group III viruses : double-stranded RNA -- Group IV viruses : single-stranded (+)sense RNA -- Group V viruses : single stranded (-)sense RNA -- Group VI viruses : single-stranded RNA reverse transcriptase viruses with a DNA intermediate in life-cycle -- Group VII viruses : double stranded DNA reverse transcriptase viruses -- Prions -- Appendices : I. Additional notes on taxonomy -- II. Number of occurrences in some common infectious diseases -- III. Organisms causing infectious disease in humans.
  • Taxonomy of Prokaryotes presents experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the microbiologist interested in this specialty, this volume may be of interest to researchers working in microbiology, immunology, virology, mycology and parasitology.
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    "Taylor's Differential Diagnosis manual is a quick-reference pocket book, written for primary care professionals who face diagnostic problems in brief office visits. It offers evidence-based guidelines on which key questions to ask and what data to obtain in order to provide sound diagnoses of common adult problems. More than 140 chapters in eighteen sections cover symptoms and signs in mental health problems, vision, ear nose and throat, cardiovascular, respiratory, urologic, female reproductive, musculoskeletal, dermatology and more. New for this edition are new chapters on abnormal mammogram, anticoagulation, bipolar disorder, corneal abrasion, dyspareunia and loss of vision as well as the latest clinical evidence and changes in clinical practice since the prior edition"--Provided by publisher.
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  • Disorders of the back and neck -- Disorders of the upper extremity -- Disorders of the lower extremity -- Osteoarthritis -- Rheumatoid arthritis and related disorders -- Selected disordeers of the musculoskeletal system -- Musculoskeletal problems of children -- Osteoporosis -- Gout -- Athletic injuries -- Care of acute lacerations -- Selected injuries.
  • Section I: General topics affecting gynecologic surgery practice -- Operative gynecology before the era of laparoscopy: a brief history / Gert H. Brieger -- The ethics of pelvic surgery / Ruth M. Farrell, Eli A. Rybak, and Edward Wallach -- Psychological aspects of pelvic surgery / Betty Ruth Speir -- Professional liability and risk management for the gynecologic surgeon / Charles J. Ward -- The changing environment in which we practice gynecologic surgery / Eric J. Bieber and Edie L. Derian -- Training the gynecologic surgeon / Robert M. Rogers, Jr. -- Section II: Principles of anatomy and perioperative considerations -- Surgical anatomy of the female pelvis / John O. L. DeLancey -- Preoperative care / Sanford M. Markham and John A. Rock -- Postanesthesia and postoperative care / Alexander Duncan, Ira R. Horowitz, and Kenneth Kalassian -- Water, electrolyte, and acid-base metabolism / Jack B. Basil -- Postoperative infections: prevention and management / W. David Hager and John W. Larsen -- Shock in the gynecologic patient / Harriet O. Smith and Heather M. Greene -- Wound healing, suture material, and surgical instrumentation / Gary H. Lipscomb -- Section III: Principles of gynecologic surgical techniques and management of endoscopy -- Incisions for gynecologic surgery / James J. Burke II and Donald G. Gallup -- Principles of electrosurgery as applied to gynecology / Richard M. Soderstrom and Andrew I. Brill -- Application of laser gynecology / John L. Marlow -- Diagnostic and operative laparoscopy / Howard T. Sharp, Sean L. Francis, and Ana Alvarez Murphy -- Operative hysteroscopy / Michael S. Baggish -- Control of pelvic hemorrhage / Howard W. Jones III and William A. Rock, Jr. -- Section IV: Surgery for fertility -- The impact of assisted reproductive technology on gynecological surgery / Howard W. Jones, Jr. -- Reconstructive tubal surgery / Victor Gomel and Elizabeth Taylor -- Endometriosis / John S. Hesla and John A. Rock -- Section V: Surgery for benign gynecologic conditions -- Surgical conditions of the vulva / Ira R. Horowitz, Joseph Buscema, and Bhagirath Majmudar -- Surgical conditions of the vagina and urethra / Celia E. Dominguez, John A. Rock, and Ira R. Horowitz -- Surgery for anomalies of the müllerian ducts / John A. Rock and Lesley L. Breech -- Normal and abnormal uterine bleeding / William J. Butler and David E. Carnovale -- Tubal sterilization / Herbert B. Peterson, Amy E. Pollack, and Jeffrey S. Warshaw -- Surgery for benign disease of the ovary / Joseph S. Sanfilippo and John A. Rock -- Persistent or chronic pelvic pain / John F. Steege -- Pelvic inflammatory disease / Mark G. Martens -- Leiomyomata uteri and myomectomy / Lesley L. Breech and John A. Rock -- Abdominal hysterectomy / Howard W. Jones III -- Vaginal hysterectomy / S. Robert Kovac -- Laparoscopic hysterectomy / Fred M. Howard -- Section VI: Surgery for obstetrics -- Management of abortion / Melissa J. Kottke and Mimi Zieman -- Ectopic pregnancy / Mark A. Damario and John A. Rock -- Obstetric problems / Cornelia R. Graves -- Ovarian tumors complicating pregnancy / Cornelia R. Graves and Lynn Parker -- Section VII: Surgery for corrections of defects in pelvic support and pelvic fistulas -- Pelvic organ prolapse----basic principles / Carl W. Zimmerman -- Site-specific repair of cystourethrocele / Carl W. Zimmerman -- Paravaginal defect repair / Bobby Shull -- Posterior compartment defects / Thomas M. Julian -- Vaginal vault prolapse / Steven D. Kleeman and Mickey M. Karram -- The nonsurgical management of pelvic organ prolapse: the use of vaginal pessaries / Rony A. Adam -- Stress urinary incontinence / Alfred E. Bent -- Operative injuries to the ureter / Paul Underwood, Jr. -- Vesicovaginal fistula and urethrovaginal fistula / G. Rodney Meeks and Ted M. Roth -- Anal incontinence and rectovaginal fistulas / Michael P. Aronson and Raymond A. Lee -- Section VIII: Related surgery -- Breast diseases: benign and malignant / Victoria L. Green -- The vermiform appendix in relation to gynecology / Barry K. Jarnagin -- Intestinal tract in gynecologic surgery / Kelly L. Molpus -- Nongynecologic condition encountered by the gynecologic surgeon / James R. Dolan and Michael D. Moen -- Section IX: Gynecologic oncology -- Malignancies of the vulva / Mitchel S. Hoffman -- Cervical cancer precursors and their management / Howard W. Jones III -- Cancer of the cervix / Dennis S. Chi ... [et al.] -- Endometrial cancer / Marta Ann Crispens -- Ovarian cancer: etiology, screening, and surgery / John R. Van Nagell, Jr., and David M. Gershenson -- Pelvic exenteration / Thomas W. Burke -- Surgical reconstruction of the pelvis in gynecologic cancer patients / Luis E. Mendez and Manuel Penalver.
  • Green tea and black tea: manufacturing and consumption / Xiaochun Wan, Daxiang Li, and Zhengzhu Zhang -- Pu-erh tea: its manufacturing and health benefits / Huai-Yuan Chen, Shoei-Yn Lin-Shiau, and Jen-Kun Lin -- White tea: its manufacture, chemistry, and health effects / He-Yuan Jiang -- Biological functions and manufacturing of GABA tea / Andi Shau-mei Ou, Yung-sheng Tsai, and Hsueh-fang Wang -- Production of theaflavins, theasinensins, and related polyphenols during tea fermentation / Takashi Tanaka, Yosuke Matsuo, and Isao Kouno -- Analytical methods for bioactive compounds in teas / Chi-Chun Wong .. [et al.] -- Bioavailability and metabolism of tea catechins in human subjects / Ting Sun, Chi-Tang Ho, and Fereidoon Shahidi -- Antioxidant properties and mechanisms of tea polyphenols / Xiaochun Wan, Daxiang Li, and Zhengzhu Zhang -- Mechanisms of cancer chemoprevention by tea and tea polyphenols / Jen-Kun Lin -- Effect of tea and tea constituents on inflammation / Divya Ramji ... [et al.] -- Inhibition of breast cancer cell proliferation by theaflavins and epigallocatechin 3-gallate through suppressing proteasomal activities / Jen-Kun Lin, Yu-Wen Chen, and Shoei-Yn Lin-Shiau -- Suppression of prostate carcinogenesis by tea polyphenols through inhibiting microsomal aromatase and 5-a-reductase / Jen-Kun Lin -- Green tea-induced thermogenesis controlling body weight / John Shi, Sophia Jun Xue, and Yukio Kakuda -- Fermented tea is more effective than unfermented tea in suppressing lipogenesis and obesity / Jen-Kun Lin and Shoei-Yn Lin-Shiau -- Trapping of methylglyoxal by tea polyphenols / Di Tan ... [et al.] -- Chemistry and biological properties of theanine / Xiaochun Wan, Zhengzhu Zhang, and Daxiang Li -- Flavor stability of tea drinks / Hideki Masuda.
  • Teach yourself visually iPad 2010
    ProQuest Safari
    Exploring the iPad -- Understanding what you can do with your iPad -- Configuring the iPad -- Getting the most from the internet -- Maximizing email on the iPad -- Syncing the iPad -- Getting the most from iTunes and photos -- Getting the most from YouTube and iBooks -- Managing contacts and appointments -- Simplifying your life with the iPad -- Enhance your iPad with the app store -- Maintaining and troubleshooting the iPad.
  • Teaching Anatomy: A Practical Guide is the first book designed to provide highly practical advice to both novice and experienced gross anatomy teachers. The volume provides a theoretical foundation of adult learning and basic anatomy education and includes chapters focusing on specific issues that teachers commonly encounter in the diverse and challenging scenarios in which they teach. The book is designed to allow teachers to adopt a student-centered approach and to be able to give their students an effective and efficient overall learning experience. Teachers of gross anatomy and other basic sciences in undergraduate healthcare programs will find in this unique volume invaluable information presented in a problem-oriented, succinct, and user-friendly format. Developed by renowned, expert authors, the chapters are written concisely and in simple language, and a wealth of text boxes are provided to bring out key points, to stimulate reflection on the reader?s own situation, and to provide additional practical tips. Educational theories are selectively included to explain the theoretical foundation underlying practical suggestions, so that teachers can appropriately modify the strategies described in the book to fit their own educational environments. Comprehensive and a significant contribution to the literature, Teaching Anatomy: A Practical Guide is an indispensable resource for all instructors in gross anatomy.
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  • This book considers the evolution of medical education over the centuries, presents various theories and principles of learning, and discusses different forms of medical curriculum and the strategies employed to develop them, citing examples from medical schools in developed and developing nations. Instructional methodologies and tools for assessment and evaluation are discussed at length and additional elements of modern medical teaching, such as writing skills, communication skills, evidence based medicine, medical ethics, skill labs, and webinars, are fully considered. In discussing these topics, the authors draw upon the personal experience that they have gained in learning, teaching and disseminating knowledge in many parts of the world over the past four decades. .
  • An case-based reference covering the full spectrum of common and uncommon problems of the gastrointestinal and genitourinary tract encountered in everyday practice. The book organizes cases into sections based on the anatomic location of the problem. Each chapter provides succinct descriptions of clinical presentation, radiologic findings, diagnosis, and differential diagnosis for the case. The chapter then discusses the background for each diagnosis, clinical findings, common complications, etiology, imaging findings, treatment, and prognosis.
  • This book is a comprehensive, hands-on guide to evaluating chest images. It is ideal for reading cover-to-cover, or as a reference of radiological presentations for common thoracic disorders.The reader will learn to interpret chest images and recognize the imaging findings, generate an appropriate differential diagnosis, and understand the underlying disease process. The atlas begins with a review of normal thoracic radiography, CT, and MR anatomy, and goes on to present cases on a wide range of congenital, traumatic, and acquired thoracic conditions. Each case is supported by a discussion of etiology, pathology, imaging findings, treatment, and prognosis in a concise, bullet format to give you a complete clinical overview of each disorder. Images demonstrate normal and pathologic findings, and complementary scans demonstrate additional imaging manifestations of disease entities.
  • Kadir (radiology, St. Louis U.) presents a guide to using interventional radiology in the treatment of non-vascular diseases of the neck, thorax, abdomen, gastrointestinal system, liver, billary system, pancreas, reproduction organs, urinary system, and adrenal glands as well as abscess drainage and biopsies. In 55 chapters, the international group of practitioners describes the clinical presentation, diagnosis, and radiological studies in addition to treatment, with illustrations in each chapter. It is the second volume to Teaching Atlas of Interventional Radiology: Diagnostic and Therapeutic Angiography.
  • "The thoroughly revised and expanded 4th edition of the bestselling "Teaching Atlas of Mammography" contains a significant number of new cases. Based on 40 years of experience, the superbly illustrated cases often show long-term follow-up of patients over a period of up to 25 years. Rather than starting with the diagnosis and demonstrating typical findings, the approach of this atlas is to teach the reader and allow him to practice through 154 paradigm cases: how to systematically review mammograms for even the most subtle hints of malignancy, and how to carefully analyze and evaluate the mammographic signs to reach the correct diagnosis. Still unique to this book is the correlation of imaging findings with the corresponding large thin-section and subgross, large thick-section (3D) histology to facilitate an understanding of the pathological processes leading to the mammographic appearances. This approach is the basis for a profound understanding of breast imaging because it is a direct and effective method of teaching differential diagnosis of benign and malignant breast diseases"--Provided by publisher.
  • I. Internal Joint Derangement; II. Tumors; III. Infection; IV. Avascular bone; V. Trauma; VI. Arthritis.
  • "Complete with the insights of leading pediatric radiologists, Teaching Atlas of Pediatric Imaging provides 125 cases that address the challenging real-life clinical problems that you are likely to encounter. Each chapter presents a different case with a complete patient work-up that includes clinical presentation, diagnosis, differential diagnoses, radiological and clinical findings, treatment summary, and suggested readings. With a view to providing the opportunity for self-assessment, the authors omit the diagnosis from the first pages of each case to enable self-testing and review."--Publisher's website.
  • This book presents a case-based approach to selecting the multimodality imaging strategies for the most frequently encountered urologic disorders. The book provides comprehensive coverage of the latest imaging techniques with an emphasis on newer modalities such as CT intravenous pyelograms (CT-IVP) and MRI for the genitourinary system. Each case opens with a concise description of the clinical presentation, radiologic findings, diagnosis, and differential diagnosis. It then concludes with a detailed discussion of the background, clinical findings, pathology, imaging findings, treatment, and prognosis for that case, and pertinent references. Features: Nearly 400 high-quality illustrations, including 47 in full color, demonstrate anatomy and pathology Consistent format of each chapter enhances ease of use Bulleted lists of differential diagnoses, this book provides a quick reference for common imaging findings and the most appropriate imaging strategies for specific diseases.
  • Provides 75 cases that cover the full range of vascular and nonvascular interventional procedures frequently performed in clinical practice. Brief sections summarizing the clinical presentation, radiologic studies, diagnosis, and treatment guide the reader through each stage of management. For each case the authors provide the essential background on the etiology of the problem and offer bulleted lists that describe the noninvasive imaging workup, therapeutic options available, and possible complications.
  • "Practical and clinically focused, Brain and Spine Imaging - a title in the Teaching Files Series - provides you with over 300 interesting and well-presented cases to help you better diagnose any disease of the brain and spine. Expert in the field, Dr. Girish Fatterpekar, MD uses a logical organization throughout, making referencing difficult diagnoses easier than ever before. Detailed discussions of today's modalities and technologies keep you up to date, and challenging diagnostic questions probe your knowledge of the material. This unique, case-based resource offers you an ideal way to sharpen your diagnostic skills and study for board exams. And, with Expert Consult functionality, you'll have convenient access to the full text online, all of the book's illustrations, additional cases and images, and links to PubMed at"--Publisher's website.
  • Teaching files. Chest 2010
    "Practical and clinically focused, this Chest title in the new Teaching Files Series provides you with 200 interesting and well-presented cases and nearly 600 high-quality images to help you better diagnose any disease of the chest. Experts in the field, Drs. Muller and Silva, use a logical organization throughout, making referencing difficult diagnoses easier than ever before. Detailed discussions of today's modalities and technologies keep you up to date, and challenging diagnostic questions probe your knowledge of the material. This unique, case-based resource offers you an ideal way to sharpen your diagnostic skills and study for exams. And, with Expert Consult functionality, you'll have convenient access to the full text online, all of the book's illustrations, additional cases and images, and links to Medline at"--BOOK JACKET.
  • "Drs. Sarah Milla and Sarah Bixby's The Teaching Files: Pediatrics provides you with interesting and well-presented clinical findings and images so you can better diagnose any pediatric disease. An easy-to-use, templated organization makes referencing difficult diagnoses easier than ever before. Discussions of today's modalities and technologies keep you up to date, and challenging diagnostic questions probe your knowledge of the material. Plus, with Expert Consult functionality, you can access the full text and illustrations online from any Internet-accessible computer."--Publisher's website.
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    Shakespeare is not a one-shot deal : an open wiki model for the humanities / John Venecek and Katheryn Giglio -- Reusable learning objects : developing online information literacy instruction through collaborative design / Matthew Sylvain, Kari Mofford, Elizabeth Lehr, and Jeannette E. Riley -- Framing multiliteracies : a blended and holistic approach to digital technology education / Andrew Whitworth, Ian Fishwick, and Steve McIndoe -- Finding your fate : the evolution of a librarian faculty collaboration to bring history online / Kristina DuRocher and Lisa Nichols -- Supported open learning : developing an integrated information literacy strategy online / Clarissa Gosling and Ingrid Nix -- Information-literate avatars : resource-based learning in Second Life / Jenna Kammer and Tracey Thompson -- Information literacy by design recalibrating graduate professional asynchronous online programs / David Lavoie, Andrew Rosman, and Shikha Sharma -- Working outside the org chart a faculty librarian partnership to design an online graduate course / Susan M. Frey and Rebecca L Fiedler.
  • Part I: Clinical and Cultural Context -- Chapter 1. Getting grounded (in our own instability) -- Chapter 2. A history exercise to locate "mindfulness" now -- Chapter 3. Building a "working" definition of mindfulness -- Part II: Authenticity, Authority, and Friendship -- Chapter 4. The Person of the Teacher -- Chapter 5. The skills of the teacher -- Part III: Towards an "Empty" Curriculum -- Chapter 6. Organizing the intentions of teaching -- Chapter 7. Fulfilling the intentions of teaching -- Chapter 8. Practices and resources.
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    v. 1. Schizophrenia, paranoid conditions [and] depressions / by P.G.S. Beckett and T.H. Bleakley -- v. 2. Psychoneurosis, organic brain disease, psychopharmacology / by P.G.S. Beckett, E.F. Domino, and T.H. Bleakley.
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    1. Web searching and the teaching paradox -- Online searching background -- Internet information growth -- Origins of the Web -- Instructional background -- The teaching connection -- Teaching simplicity -- The state of Web searching today -- Changing patterns -- 2. Understanding our audience -- General audience characteristics -- Novices -- Know-it-alls -- Experienced users -- Pairing strategies for hands-on workshops -- Audience assessment -- Navigation versus search confusion -- Remembering what we did not know -- Box confusion -- Address confusion -- Button confusion -- Browser differences and problems -- Operating system and hardware issues -- Adaptability and change -- 3. Choosing an instructional session type -- Hands-on sessions -- Advantages -- Disadvantages -- Facilities -- Planning -- Exercises -- Lecture and demonstration sessions -- Advantages -- Disadvantages -- Facilities -- Planning -- Semi-online tutorials -- Capturing a screen shot within PowerPoint -- Course coverage and distance education -- Other settings and approaches -- 4. Online tutorials : friend or foe? -- Advantages -- Disadvantages -- Issues with online tutorials for Web searching -- Search engine inconsistencies -- Search feature changes -- Databases changes -- Online tutorial examples -- Web search guide tutorial : research, Web searching -- Finding information on the Internet : a tutorial -- Internet tutorials -- LearnAndGo, searching the Web -- Quick tutorial on searching the Internet -- Net.TUTOR : using Web search tools -- Interactive tutorials : Internet search tips and mouse exercise -- Tutorial : site clustering and filtering -- The information cycle -- Information literacy online tutorials -- Finding tutorials -- Tutorials : worth the effort? -- 5. Organization : focus, length, and goals -- Primary session focus -- Pure Web searching -- Basic Internet training -- Advanced Internet training -- Part of multiple sessions -- Course-integrated bibliographic instruction -- Session length -- Variations in length -- Ideal length -- The burnout paradox -- Goal setting -- A collection of goals -- How many main goals? -- Specific objectives -- Bringing it all together -- 6. Terminology -- Importance of terminology -- Definitions -- Search engine -- Directory -- Portal -- Metasearch engine -- Ad bidding engine -- Answer engine -- Metasite -- News search engine -- Opinion engine -- Site search engine -- Invisible Web -- Other terminology distinctions -- Final thoughts on terminology -- 7. Content : Web search features -- Search features -- Phrase searching -- Boolean searching -- Truncation -- Field searching -- Limits -- Stop words and case sensitivity -- Sorting -- The teaching choice -- 8. Content : primary concepts -- Research process -- Question analysis -- Using more than one search tool -- Search engines versus directories -- Evaluation -- Which primary concepts to teach -- Recent changes in teaching topics -- Additional concepts to consider -- Identifying ads -- Understanding Web addresses (or URLs) -- Understanding databases -- Teaching change -- 9. Additional content : image searching, news, Usenet, and more -- News -- Usenet newsgroups and opinions -- Pictures and images -- Multimedia -- Phone numbers -- Bibliographic databases -- Subject-specific sites -- Invisible Web -- The lost obvious -- 10. The search engines -- The starting point -- Ask -- Exalead -- Gigablast -- Google -- MSN search -- Windows Live -- Yahoo! -- Directories -- 11. Creating a framed workshop Web page -- Advantages and disadvantages of frames -- Frames code and explanation -- Top page with frameset -- Left frame table of contents -- Content pages -- Exercise pages frame set -- Exercise one top frame : JavaScript and a form -- Other exercise pages -- Solutions for frame breakers -- 12. Presentation tips, tricks, and shortcuts -- Keyboard shortcuts -- General Windows shortcuts -- Browser shortcut keys -- Shortcuts for filling out forms -- Other shortcuts -- Quick links and the personal toolbar -- Bookmarklets -- Zapping images, animations, and more -- Bookmarklets for Web searching -- The pop-up presence -- The shortcut advantage -- 13. Tales from the trenches : anecdotes, examples, and exercises -- Analogies, sayings, and terminology tales -- Boolean examples -- Exercises -- Unexpected answers -- Limitations of search engines -- Failures -- Facilities failures -- The team teaching danger -- Web site instruction and the Web searching paradox -- Lost interest -- Formulas for success -- Afterword -- Appendix A. The trainers : introduction to the interviewees -- Appendix B. Sample handouts and other training material -- Appendix C. URL list.
  • Part I. Understanding Tech Mining -- Chapter 1. Technological Innovation and the Need for Tech Mining , p. 2-15 -- Chapter 2. How Tech Mining Works, p. 17-32 -- Chapter 3. What Tech Mining Can Do for You, p. 33-40 -- Chapter 4. Example Results. Fuel Cells Tech Mining, p. 41-50 -- Chapter 5. What to Watch for in Tech Mining, p. 51-66 -- Part II. Doing Tech Mining -- Chapter 7. Forming the Right Query, p. 95-111 -- Chapter 8. Getting the Data, p. 113-127 -- Chapter 9. Basic Analyses, p. 129-154 -- Chapter 10. Advanced Analyses, p. 155-186 -- Chapter 11. Trend Analyses, p. 187-214 -- Chapter 12. Patent Analyses, p. 215-248 -- Chapter 13. Generating and Presenting Innovation Indicators, p. 249-288 -- Chapter 14. Managing the Tech Mining Process, p. 289-306 -- Chapter 15. Measuring Tech Mining Results, p. 307-320 -- Chapter 16. Example Process. Tech Mining on Fuel Cells, p. 321-354 -- Appendix A. Selected Publication and Patent Databases, p. 355-359 -- Appendix B. Text Mining Software, p. 361-362 -- Appendix C. What You Can Do without Tech Mining Software, p. 363-364 -- Appendix D. Statistics and Distributions for Analyzing Text Entities, p. 365-368.
  • Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.
  • This well-received book, now in its fifth edition, is unique in providing a detailed description of the technological basis of radiation therapy. Another novel feature is the collaborative writing of the chapters by North American and European authors. This considerably broadens the book{u2019}s perspective and increases its applicability in daily practice throughout the world. The book is divided into two sections. The first covers basic concepts in treatment planning, including essential physics and biological principles related to time-dose-fractionation, and explains the various technological approaches to radiation therapy, such as intensity-modulated radiation therapy, tomotherapy, stereotactic radiotherapy, and high and low dose rate brachytherapy. Issues relating to quality assurance, technology assessment, and cost-benefit analysis are also reviewed. The second part of the book discusses in depth the practical clinical applications of the different radiation therapy techniques in a wide range of cancer sites. All of the chapters have been written by leaders in the field. This book will serve to instruct and acquaint teachers, students, and practitioners in the various fields of oncology with the basic technological factors and approaches in radiation therapy.
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    v. 1. Physical methods of organic chemistry.
  • "Cartilage defects are common. Cartilage repair surgery is not only fascinating but also surgically challenging. There are books dealing with basic science and some surgical aspect. This book fills a gap in surgical techniques for cartilage repair. All of the surgical chapters are logically organised, covering patient selection, patient setup/positioning, surgical approach, potential complications and troubleshooting. An attempt is made to compare with various surgical techniques. This book also covers anaesthesia, postoperative follow-up, pain management and rehabilitation. Both the editors and the authors are renowned experts in the field. This book will be invaluable for orthopaedic and sports medicine surgeons (consultants and training doctors) and is also of potential interest to physiotherapists, medical students, general practitioners, physical medicine and rehabilitation specialists, and rheumatology specialists."--Publisher's website.
  • v. 9-, 2007- ClinicalKey
  • Drs. Jon K. Sekiya, Marc Safran, Anil S. Ranawat, and Michael Leunig provide a step-by-step, balanced approach-with contributions from an array of North American and international surgeons-to pre-operative planning, surgical technique, technical pearls, management of complications, and post-operative rehabilitation. Surgical videos on DVD demonstrate techniques such as surgical hip dislocation for femoracetabular impingement and arthroscopic femoral osteoplasty so you can provide your patients with the best possible outcomes. Grasp the visual nuances of each technique through full-color surgical illustrations and intraoperative photographs. Watch expert surgeons perform cutting edge procedures-such as complex therapeutic hip arthroscopy using a femoral distractor, arhroscopic synovectomy and treatment of synovial disorders, surgical hip dislocation for femoracetabular important, and arthroscopic femoral osteoplasty-on DVD. Find information quickly and easily thanks to the consistent chapter format that includes technical pearls.
  • Techniques in Revision Hip and Knee Arthroplasty is the one authoritative volume that gives you an efficient, problem-based approach to revision arthroplasty of both the hip and knee. Dr. Giles Scuderi and other leading experts from North America and Western Europe present their favored surgical procedures and post-surgical management strategies in this straightforward, heavily illustrated, video-intensive reference. It's your one-stop, go-to guide for successful revision surgery for a myriad of complications, such as implant loosening, polyethylene wear, osteolysis, or infection of the hip and knee. Get expert guidance on implant choice, management of complications (including infection and wound healing), and failure of mechanisms, as well as step-by-step surgical techniques.Quickly find the exact information you need with a straightforward "just what you need to know" approach, including surgical tips and pearls.Stay up to date with new insights regarding anatomic landmarks, recommended reconstruction options in revision surgery, including management of bone defects and instability.Access the fully searchable contents of the book and an abundance of surgical videos online at Expert Consult.
  • Wrist arthroscopy portals / David J. Slutsky -- Trapeziometacarpal and scaphotrapezial arthroscopy portals / David J. Slutsky -- The ulnocarpal joint. Arthroscopically assisted ulnar shortening / Daniel J. Nagle -- Arthroscopic treatment of radial-sided TFCC lesions / Jennifer Weintraub, A. Lee Osterman, and Jeffrey Yao -- Peripheral tears of the TFCC: arthroscopic diagnosis and management / Thomas E. Trumble and Seth D. Dodds -- Arthroscopy of the distal radioulnar joint / Ericka A. Lawler and Brian D. Adams -- Class IIA and B ulnar impaction: treatment with arthroscopic TFCC disc excision and wafer distal ulna resection / Matthew M. Tomaino -- Carpal ligament injury. Arthroscopic treatment of scapholunate ligament tears / Steven H. Goldberg ... [et al.] -- Arthroscopic RASL / Michael R. Hausman -- Arthroscopic thermal shrinkage for scapholunate ligament injuries / Ferdinando Battistella, Pau Golano, and Ettore Taverna -- Arthroscopic treatment of lunotriquetral ligament injuries / Gregory J. Hanker -- Arthroscopic plication of lunotriquetral ligament tears / Jason W. Levine, Felix H. Savoie III, and Michael J. Moskal -- Arthroscopic dorsal readiocarpal ligament repair / David J. Slutsky -- The role of arthroscopy in midcarpal instability / David M. Lichtman ... [et al.] -- Capsular shrinkage in the treatment of wrist instability / David J. Nagle -- Writst and carpal fractures. Arthroscopically assisted reduction and percutaneous fixation of scaphoid fractures using a simple external targeting system / Joseph F. Slade III and Greg Merrell -- The role of wrist arthroscopy in intra-articular distal radius fracture management / William B. Geissler -- Correction of mal-united intra-articular distal radius fractures with and inside-out osteotomy technique / Franscisco del Piñal -- Arthroscopic wrist capsulotomy / David J. Slutsky -- Arthroscopic synovectomy and abrasion chondroplasty of the wrist / Kevin D. Plancher and Césaw J. Bruno -- Arthroscopic wrist ganglionectomy / Randy R. Bindra -- Arthroscopic treatment of volar carpal ganglion cysts / Jeffrey A. Greenberg -- Arhtoscopically assisted treatment of intraosseous gaglions of the lunate / N. Ashwood and G.I. Bain -- Arthroscopic radial styloidectomy / David J. Slutsky -- Arthroscopic resection of arthosis of the proximal hamate / Brian J. Harley and Andrew K. Palmer -- Arthroscopic proximal row carpectomy / Randall W. Culp and Eric S. Wroten -- Anthroscopy of the small joints of the hand / Richard A. Berger -- Small-joint arthroscopy. Arthroscopic treatment of trapeziometacarpal diseaes / David J. Slutsky -- Arthroscopic debridement for isolated scaphotrapeziotrapezoid arthritis / N. Ashwood and G.I. Bain -- Extra-articular procedures. Agee endoscopic carpal tunnel release / David J. Slutsky -- Endoscopic carpal tunnel release: the chow dual-portal technique / Daniel J. Nagle -- Endoscopic release of the first dorsal extensor tendon compartment / Joseph F. Slade III and Greg Merrell.
  • Glycemic control -- Home blood glucose monitoring -- Continuous glucose monitoring -- Insulin delivery system -- Closed-loop insulin-delivery system -- Alternatives to insulin injection -- Devices to support treatmtne decisions -- Electronic medical record.
  • Rapid progress in health research has led to generation of new knowledge and innovative practices in management of illness. This has resulted in a significant challenge for health professionals: if today we discovered a new therapy through research, when will this discovery be regularly prescribed or utilized to treat all patients suffering from this condition? Knowledge translation is the non-linear and often complicated process of translating knowledge into routine health practices. Technology enabled knowledge translation (TEKT) is the use of information and communication technologies (ICT) to accelerate knowledge translation. With the ubiquity of the internet, the proliferation of different approaches in communication and social networking, and the continuously improving technologies from netbooks to smartphones, there are rich opportunities for TEKT in health education, service delivery, and research.
  • Applied groundwork for a practical moral code. Introduction ; Definitions ; Professional moral codes ; USDA study : methodology and results ; Formalization and evaluation of the USDA study's moral codes ; Formalization of the combination moral code ; Problems for the combination moral code ; Conclusion -- A practical moral code. Introduction ; Utilitarianism ; What is a reasonable person? ; RPU's benefits ; Respecting persons ; Working toward a plausible distributive/social justice principle ; The moral paradigm test ; Conclusion -- Are transgenic organisms, biotechnology, and technology unnatural? Introduction ; The unnatural is unethical argument ; The weak definitions ; A "playing God" argument ; More complex meanings of the unnatural ; Arguments from evolution ; Conclusion -- A natural theory of value. Introduction ; Naturalness as sacredness ; Beginning an axiology ; The benefit of the doubt principle ; Intrinsically valuable things and their rankings ; Is nature or the biosphere alive? ; Arguments against nature's intrinsic value ; Conclusion -- Applying PMC to a few transgenic technology issues. Introduction ; The practical moral code again ; Transgenics and RPU ; Transgenics and QCI ; Legal/moral questions ; Conclusion.
  • Wake Forest University -- Basic Physics of Ultrasound -- Systolic LV Structure/Function -- Diastolic Function -- Aortic Valve Anatomy -- Aortic Valve Stenosis -- Aortic Regurgitation -- Mitral Valve Anatomy -- Mitral Valve Stenosis -- Mitral Valve Regurgitation -- Pulmonic Valve -- Tricuspid Valve -- Right Ventricle -- Prosthetic Valve Types -- Eendocarditis -- Pericardial Disease -- Aoritc Atherosclerosis Aneurysm Dissection -- Adult Congenital Heart Disease -- Intracardiac Masses and Objects -- Artifacts and Pitfalls -- Equations and Calculations -- Intraoperative Aoperative ₃-Dimensional (₃D) Tee.
  • On the relationship between calculus and caries / Duckworth, R.M., Huntington, E. -- The structure, function and properties of the acquired pellicle / Hannig, M., Joiner, A. -- Model parameters and their influence on the outcome of in vitro demineralisation and remineralisation studies / Lynch, R.J.M. -- Tooth wear / Pickles, M.J. -- Nanomechanics, chemistry and structure at the enamel surface / Mann, A.B., Dickinson, M.E. -- Plaque as a reservoir for active ingredients / Duckworth, R.M., Gao, X.J.
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  • Tele-oncology 2015
    1 Introduction -- 2 Overview and Background -- PART I -- Fields of application 3 The community: Early diagnosis and prevention -- 4 The hospital: Improving hospital care for people with cancer -- 5 Home-based care for a better quality of life: Treatment, monitoring and follow-up -- PART II -- Technical Issues 6 New technologies and new frontiers -- 7 The social web -- PART III -- Complex Scenarios and Special Settings -- 8 Rural and extreme rural settings -- 9 Tele-oncology in developing countries -- PART IV -- eLearning 10 Education and distant learning -- 11 Health education to improve prevention -- 12 Conclusions.
  • Pt. 1. System : tele-healthcare monitoring networks -- pt. 2. Hardware : medical sensors and devices -- pt. 3. Software : medical signal processing -- pt. 4. Others : medical security and privacy.
  • "This book describes in detail the potential role of ICT and electronic systems, together with the application of Web 2.0 technologies, in telepediatrics and child health. Rather than simply proposing engineering solutions that may soon become outdated, it is designed to address those real needs that telemedicine and developers are asked to meet. The orientation of the book is very much toward primary care, and both low- and high-income settings as well as extreme or complex scenarios are considered. The first two sections of the book describe different fields of application, such as the community, the hospital, and children with chronic illnesses or special needs, and examine technical issues. The use of telemedicine in delivery of care in extreme rural settings and developing countries is then discussed, with attention also to major emergencies and humanitarian crises. The closing chapters consider the role of modern technologies in the education of caregivers who work with children. Child health is a crucial issue in both industrialized and developing countries. Telemedicine for Children's Health will be an excellent guide to the potential value of telemedicine devices in reducing the burden for children and parents and in offering quick and concrete solutions in low-resource scenarios"--Provided by publisher.
  • Introduction to Teledermatology -- Historical Review -- Medical Prerequisites -- Technical Prerequisites -- Photographic Imaging Essentials -- Performance of Teledermatology including Clinical Examples -- Teledermatology in Underdeveloping Countries -- Special Methods of Teledermatology -- Teledermatology and Reflectance Confocal Microscopy Quality Assurance -- Legal Assumptions -- Economic Aspects and Cost-effectiveness -- Future Horizons -- APPENDIX: Education and Training Opportunities -- Quality Certificate Teledermatology -- Sample Protocol, Consent Form and Information Sheet -- References and Relevant Web links -- Glossary -- Subject Index.
  • Part 1. GENERAL -- History of Microsurgery / Yoshikazu Ikuta -- History of Telesurgery / James Wall and Jacques Marescaux -- Description of Robots / Jesse Creed Selber -- Instruments / Sijo Joseph Parekatti and Michael Moran -- Robot Installation in Telemicrosurgery / Thierry Lequint, Kiyohito Naito, Eric Nectoux, Sybille Facca and Philippe Liverneaux -- Part 2. TRAINING -- Earthworms / Gustavo Mantovani Ruggiero -- Vessels / Joo-Yup Lee and Alexander Y. Shin -- Nerves / Stacey H. Berner -- Part 3. EXPERIMENTAL RESEARCH -- Free Tissue Transfer / Stacey H. Berner -- Tele-endomicrosurgery / Sybille Facca, Kiyohito Naito, Thierry Lequint, Eric Nectoux and Philippe Liverneaux -- Brachial Plexus Repair / Gustavo Mantovani Ruggiero and Philippe Liverneaux -- Tendon Transfer / Michael S. Bednar -- Part 4. CLINICAL APPLICATIONS -- Nerve Entrapment / Jose Carlos Garcia Jr. -- Nerve Repair / Stacey H. Berner -- Brachial Plexus / Kiyohito Naito, Mickaël Ohana, Thierry Lequint, Sybille Facca and Philippe Liverneaux -- Skin Flaps / Thomas Lauwers, Tom Van Mulken and Darren Booi -- Muscle Flaps / Jesse Creed Selber and John C. Pedersen -- Head and Neck / Jesse Creed Selber -- Urology / Sijo Joseph Parekattil -- Part 5. PERSPECTIVES -- Supermicrosurgery / Takeshi Todokoro and Isao Koshima -- Network / Catherine Jane Mohr.
  • "Medical information is now widely available on the Internet and through telephone helplines such as NHS Direct and the focus on patient self care is likely to increase. Clinicians in all specialties will often encounter patients who have made self-directed searches for medical information prior to the clinical encounter. 'Teleneurology by Internet and Telephone' is a study of patient information-seeking behaviour in neurology patients prior to referral from primary to secondary care. The book analyses frequency of Internet access and use, and of telephone helpline awareness and use. It also explores use of these modalities over time, use according to patient gender and age and by gender and age over time. 'Teleneurology by Internet and Telephone' is an accessible overview of the utility of these modalities of health information provision and will be of interest not only to neurologists and clinicians in other specialities but also to public health researchers, sociologists and political scientists with an interest in questions of health care provision"--Provided by publisher.
  • Teleneurology in the United States Veteran Health Administration -- International Teleneurology -- Military Telemedicine -- Telemedicine Technology -- Telestroke -- Teleneurointensive Care Unit (TeleneurolICU) -- Teleneurology and Neurointerventional Therapy for Acute Stroke -- Teleneurosurgery -- Hospital Teleneurology -- Telemedicine and Parkinson Disease -- Telebeuropatholgy -- Tele-Epilepsy and Tele-Electroencephalography -- The Emerging Relevance of Telemedicine in Sleep Medicine -- Teledementia -- The Emerging Role of Telemedicine in the Evaluation of Sports-related Concussion -- Teleneurology in Contemporary Graduate Medical Education -- Legal Considerations in the Use of Telemedicine in Neurology -- Reimbursement in Teleneurology.
  • Telenursing 2011
  • Teleophthalmology 2006
  • Applications of Teleophthalmology: Systemic Diseases (Applications) -- Ocular Diseases. Methods used in Teleophthalmology: Novel Imaging Devices -- Information Technologies.
  • Telepathology 2009
  • Teleradiology 2008
  • Telerehabilitation 2013
    Telerehabilitation, as a subset of telehealth, is the use of telecommunications to deliver rehabilitation services at a distance and can bridge the gaps created by personnel shortages that exist in underserved and remote areas, as well as serve persons in urban settings who cannot easily leave their homes or offices to seek care. Given the mobile nature of our society, telerehabilitation can enable continuity of care while persons travel for work, vacation and/or education. While the technical capacities to conduct telerehabilitation have surged ahead in the past 10 years, there has been slower, yet ongoing progress in the development of the policies (e.g., legislation; state licensure; reimbursement) that will be required to actualize widespread telepractice service delivery. Telerehabilitation presents a wide-angle view of telerehabilitation worldwide at a seminal time in its development. The book contains contributions from authors across multiple disciplines, as well as a consumer-based perspective. This book contributes significantly to the current understanding of telerehabilitation, as well as elucidating the immense potential for telerehabilitation-based service delivery to benefit persons with disabilities.
  • Telesurgery 2008
  • Methods of telomerase inhibition -- Telomerase inhibition by synthetic nucleic acids and chemosensitization in human bladder cancer cell lines -- hTERT knockdown in human embryonic kidney cells using double-stranded RNA -- RNA interference using a plasmid construct expressing a short-hairpin RNA -- Retrovirus-mediated RNA interference -- Telomerase inhibition and telomere targeting in hematopoietic cancer cell lines with small non-nucleosidic synthetic compounds (BIBR1532) -- Uses of telomerase peptides in anti-tumor immune therapy -- Establishing cell-based reporter systems for the analysis of hTERT expression -- Telomerase RNA inhibition using antisense oligonucleotide against human telomerase RNA linked to a 2',5'-oligoadenylate -- Knockdown of telomerase RNA using hammerhead ribozymes and RNA interference -- Evaluation of tankyrase inhibition in whole cells -- Inhibition of telomerase by targeting MAP kinase signaling -- Screening of telomerase inhibitors -- Telomerase inhibition combined with other chemotherapeutic reagents to enhance anti-cancer effect.
  • Introduction to telomeres and telomerase / Z. Songyang -- Analysis of average telomere length in cultured human cells / D. Liu -- Telomere length analysis by quantitative fluorescent in situ hybridization (Q-FISH) / I. Ourliac-Garnier and A. Londono-Vallejo -- Telomere strand-specific length analysis by fluorescent in situ hybridization (Q-CO-FISH) / I. Ourliac-Garnier and A. Londono-Vallejo -- Telomere G-overhang length measurement method 1: The DSN method / Y. Zhao, J.W. Shay and W.E. Wright -- Telomere G-overhang length measurement method 2: G-tail telomere HPA / H. Tahara -- Telomere terminal G/C strand synthesis: Measuring telomerase action and C-RICH fill-in / Y. Zhao, J.W. Shay and W.E. Wright -- G-quadruplex structures and G-quadruplex-interactive compounds / R.I. Mathad and D. Yang -- Analysis of yeast telomerase by primer extension assays / M. Hsu and N.F. Lue -- Telomeric repeat amplification protocol: Measuring the activity of the telomerase / H. Xin -- CO-FISH, COD-FISH, ReD-FISH, SKY-FISH / E.S. Williams [and others] -- Visualization of human telomerase localization by fluorescence microscopy techniques / E. Abreu, R.M. Terns and M.P. Terns -- Cytogenetic analysis of telomere dysfunction / A.S. Multani and S. Chang -- Probing the telomere damage response / R. Rai and S. Chang -- Analysis of telomere proteins by chromatin immunoprecipitation (CHIP) / W. Ma -- Studying of telomeric protein-protein interactions by bi-molecular fluorescence complementation (BIFC) and peptide array-based assays / W. Ma, H. Kim and Z. Songyang -- Human telomere POT1-TPP1 complex and its role in telomerase activity regulation / F. Wang and M. Lei.
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    A history of telomere biology -- The telomerase ribonucleoprotein particle -- Telomerase biochemistry and biogenesis -- Telomerase and human cancer -- Modeling cancer and aging in the telomerase-deficient mouse -- Telomerase deficiency and human disease -- Telomerase-independent maintenance of mammalian telomeres -- Telomerase-independent telomere maintenance in yeast -- Meiotic telomeres -- Telomere position effect : silencing near the end -- The structural biology of telomeres -- Budding yeast telomeres -- Mammalian telomeres -- Drosophila telomeres -- Ciliate telomeres -- Fission yeast telomeres -- Plant telomeres.
  • Imaging Technique -- Anatomy -- Multiplanar Atlas -- Advanced Imaging Applications -- Imaging Microscopy of the Temporal Bone: An Anatomy Tutorial.
  • This book, featuring more than 180 high spatial resolution images obtained with state-of-the-art MDCT and MRI scanners, depicts in superb detail the anatomy of the temporal bone, recognized to be one of the most complex anatomic areas. In order to facilitate identification of individual anatomic structures, the images are presented in the same way in which they emanate from contemporary imaging modalities, namely as consecutive submillimeter sections in standardized slice orientations, with all anatomic landmarks labeled. While various previous publications have addressed the topic of temporal bone anatomy, none has presented complete isotropic submillimeter 3D volume datasets of MDCT or MRI examinations. The Temporal Bone MDCT and MRI Anatomy offers radiologists, head and neck surgeons, neurosurgeons, and anatomists a comprehensive guide to temporal bone sectional anatomy that resembles as closely as possible the way in which it is now routinely reviewed, i.e., on the screens of diagnostic workstations or picture archiving and communication systems (PACS).
  • Temporal bone imaging 2008
    Thieme Book
    This new text covers the most important concepts of temporal bone imaging. Each chapter is organized by disease entity, including congenital malformations, neoplasms, infections/inflammatory, post-operative and more. With a wealth of information provided in an easy-to-read format, this text is ideal for neuroradiologists, radiologists and other specialists.
  • This book provides a complete overview of imaging of normal and diseased temporal bone. After description of indications for imaging and the cross-sectional imaging anatomy of the area, subsequent chapters address the various diseases and conditions that affect the temporal bone and are likely to be encountered regularly in clinical practice. The classic imaging methods are described and discussed in detail, and individual chapters are included on newer techniques such as functional imaging and diffusion-weighted imaging. There is also a strong focus on postoperative imaging. Throughout, imaging findings are documented with the aid of numerous informative, high-quality illustrations. Temporal Bone Imaging, with its straightforward structure based essentially on topography, will prove of immense value in daily practice.
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    Structure of the oral tissues -- General embryology -- Embryology of the head, face, and oral cavity -- Cytoskeleton, cell junctions, fibroblasts, and extracellular matrix -- Development of the tooth and its supporting tissues -- Bone -- Enamel : composition, formation, and structure -- Dentin-pulp complex -- Periodontium -- Physiologic tooth movement : eruption and shedding -- Salivary glands -- Oral mucosa -- Temporomandibular joint -- Facial growth and development -- Repair and regeneration of oral tissues.
  • Sect. I: Pulmonary arteries, aorta, peripheral vessels -- Sect. II: Coronary arteries -- Sect. III: Intracardiac masses -- Sect. IV: Endocardium and valves -- Sect. V: Pericardium and myocardium -- Sect. VI: Congenital heart disease.
  • Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology -- The Discovery of GW Bodies -- The Discovery and Analysis of P Bodies -- Autoantibodies to Argonaute 2 (Su Antigen) -- GW/P-Bodies and Autoimmune Disease -- Function of GW182 and GW Bodies in siRNA and miRNA Pathways -- Post-transcriptional Stimulation of Gene Expression by MicroRNAs -- Gawky (GW) is the Drosophila melanogaster GW182 Homologue -- The Role of GW182 Proteins in miRNA-Mediated Gene Silencing -- Quantifying Argonaute Proteins In and Out of GW/P-Bodies: Implications in microRNA Activities -- Deadenylation and P-Bodies -- Relationship of GW/P-Bodies with Stress Granules -- Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies -- An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182 -- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research.
  • Part I. Basic Sciences, Etiology, Pathomechanics, and Imaging --1. Anatomy of Tendons / Moira O'Brien, p. 3-13 -- 2. Mechanical Properties of Tendons / Constantinos Maganaris and Marco Narici, p. 14-21 -- 3. Growth and Development of Tendons / Laurence Dahners, p. 22-24 -- 4. Aging and Degeneration of Tendons / Pekka Kannus, Mika Paavola and Lászlo Józsa, p. 25-31 -- 5. Epidemiology of Tendon Problems in Sport / Mika Paavola, Pekka Kannus and Markku Järvinen, p. 32-39 -- 6. Neurogenic, Mast Cell, and Gender Variables in Tendon Biology: Potential Role in Chronic Tendinopathy / David Hart, Cyril Frank, Alison Kydd, Tyler Ivie, Paul Sciore and Carol Reno, p. 40-48 -- 7. Imaging of Tendon Ailments / Tudor Hughes, p. 49-60 -- Part II. Anatomical Sites and Presentation -- 8. Injury of the Musculotendinous Junction / Jude Sullivan and Thomas Best, p. 63-69 -- 9. Insertional Tendinopathy in Sports / Per Renström and Thomas Hach, p. 70-85 -- 10. Tendon Avulsions in Children and Adolescents / Sakari Orava and Urho Kujala, p. 86-89.
  • "Get the best results from the latest procedures with Tendon Surgery of the Hand , the only reference that offers comprehensive coverage of this complex and challenging area. World-renowned experts guide you through all of the newest techniques and technologies , equipping you to restore optimal function in your patients. It's your one-stop source for mastering today's best approaches to treating tendon injuries and disorders of the hand."--Publisher's website.
  • Section I: Etiology -- Definition, Causes and Epidemiology -- Tennis Elbow in Athletes: More Than Just Tennis? -- Golfer's Elbow: Treatment Distinctions -- Section II: Conservative Treatment -- Evidence for No Treatment and Self-limited Treatment -- Medical Management: The Role of NSAIDS and Topical -- Therapy -- Splints -- Steroid Injections -- Blood and PRP Injections -- Other Treatments: Prolotherapy, Acupuncture, ESWL -- Section III: Surgery -- Open Surgical Treatment -- Arthroscopic Treatment -- Denervation -- Percutaneous Release -- Outcomes of Treatment and Return to Play: The Evidence -- Complications of Surgical Treatment and Salvage Procedures for Failed Surgery.
  • Introduction / Peter L. Elkin and Mark Samuel Tuttle -- History of Terminology and Terminological Logics / Peter L. Elkin and Mark Samuel Tuttle -- Knowledge Representation and the Logical Basis of Ontology / Peter L. Elkin and Steven H. Brown -- Theoretical Foundations of Terminology / Peter L. Elkin -- Compositionality: An Implementation Guide / Peter L. Elkin and Steven H. Brown -- Interface Terminologies / S. Trent Rosenbloom -- Springer Terminology Related Standards Development / Peter L. Elkin -- Implementations of Terminology / Peter L. Elkin, Mark Samuel Tuttle, Marjorie Rallins, Jennifer Trajkovski and Elizabeth Lumakovska, et al. -- Terminological Systems / Peter L. Elkin and Mark Samuel Tuttle -- Conclusion / Peter L. Elkin and Mark Samuel Tuttle.
  • Toward a comprehensive strategy for terrorism and homeland security / Paul R. Viotti -- The search for national and homeland security : an integrated grand strategy / Robert H. Dorff -- Assured vulnerability : homeland security and the cold war legacy of defenselessness / David Goldfischer -- Terrorism and deterrence by denial / James M. Smith and Brent J. Talbot -- The importance of multinational and transnational cooperation strategies for homeland security / Veronica M. Kitchen and Gregory J. Moore -- WMD terrorism : new threats, revised responses / Jeffrey A. Larsen and James J. Wirtz -- Nuclear and radioactive threats to homeland security : prevention and response / Fred L. Wehling and Jeremy Tamsett -- Comparative risk analysis : biological terrorism, pandemics, and other "forgotten" catastrophic disaster threats / Terrence M. O'Sullivan -- Homeland security strategy and policy choices : a local government perspective / Greg Moser -- Democracy, civil society and the damage-limitation component of strategy / Alexander C. Diener and Timothy W. Crawford -- Transportation as a component of homeland security strategy / Joseph S. Szyliowicz -- Redefining U.S. energy security in the twenty-first century / Kevin King -- Afterword: terrorism and securing the homeland / Michael A. Opheim and Nicholas H. Bowen.
  • Section 1. Know the terrorist. Your mission : critical awareness -- Who they are : identify terrorist operatives -- Intelligence profiling suspected terrorists -- Terrorist training -- Terrorism 101 : why the terrorist chooses this path -- What terrorists believe -- Section 2. Identifying the terrorist group and its cells. Terrorist group organization -- The terrorist cell -- Terrorist strategies and target selection -- Section 3. Detection of key terrorist activities. Terrorist preparations for attack : safe houses, finances, and mobility -- The terrorist's tools : conventional weapons identification -- The terrorist's tools : nuclear, biological, chemical weapons and equipment identification -- Section 4. Predicting an attack. Terrorist surveillance techniques -- Detecting infiltration and special mission techniques -- The decision and attack sequence -- The basics of analyzing intelligence and predicting terrorism events -- Point of danger : law enforcement traffic stops and encountering terrorists -- Point of failure : terrorist operations and tactics -- Section 5. The new fields of terror. A primer on Al-Qaeda and the global extremist insurgency -- Suicide terrorism : tactics, equipment and management -- Terrorism and insurgency in the Iraq War (2003-2008) -- Section 6. Supplemental data, bibliography and appendices . Appendix A. Global terrorist groups -- Appendix B. Explosive components & ingredients checklists.
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  • This volume provides a brief resume of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.
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    Intended audience -- Significance -- Roadmap -- General testing format -- Advance notification and disguised tests -- Avoiding false alarms -- Testing levels -- Debriefing procedures -- Staffing and materials -- Choosing a testing agency -- Choosing an appropriate test -- Developing call schedules and background stories -- Trainer responsibilities -- Training session 1: Preparing for a test and debriefing -- Training session 2: Practice and observation -- Initiating a call -- Reaching an action officer -- Debriefing -- Performance criterion -- Generating an after action report -- Continuous quality improvement.
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  • Introduction to the tethered cord syndrome / Shokei Yamada -- Normal spinal cord development and the embryogenesis of spinal cord tethering malformations / Mark S. Dias and Elias B. Rizk -- Pathophysiology of the tethered cord syndrome / Shokei Yamada ... [et al.] -- Neurologic assessment of tethered spinal cord / Sanford Schneider -- Imaging of tethered spinal cord / David B. Hinshaw ... [et al.] -- Ultrasonographic evaluation of tethered cord syndrome / Marvin D. Nelson Jr -- Urological aspect of tethered cord syndrome I : lower urinary tract dysfunction in tethered cord syndrome / H. Roger Hadley ... [et al.] -- Urological aspect of tethered cord syndrome II : clinical experience in urological involvement with tethered cord syndrome / Antoine E. Khoury -- The cervical tethered spinal cord / Kenji Muro, Arthur J. DiPatri Jr., and David G. McLone -- Indication and treatment of tethered spinal cord / James M. Drake and Harold J. Hoffman. Tethered cord syndrome associated with myelomeningoceles and lipomyelomeningoceles / Shokei Yamada ... [et al.] -- The role of folate supplementation in spina bifida occulta / Elias Rizk and Bermans J. Iskandar -- In utero repair of myelomeningoceles / Nalin Gupta -- Epidermoid and dermoid tumors associated with tethered cord syndrome / David S. Knierim, Daniel J. Won, and Shokei Yamada -- Tethered cord syndrome in adult and late-teenage patients without neural spinal dysraphism / Shokei Yamada ... [et al.] -- Tethered cord syndrome in adults with spina bifida occulta / Sharad Rajpal, Samir B. Lapsiwala, and Bermans J. Iskandar -- The normal position of the conus medullaris does not exclude a tethered spinal cord / R. Shane Tubbs and W. Jerry Oakes -- Anomalies of the spinal cord length and filum thickness / Shokei Yamada, Javed Siddiqi, and Shoko M. Yamada -- Intraoperative neurophysiological monitoring of the lower sacral nerve roots and spinal cord / Dachling Pang -- Clinical neurophysiology of tethered cord syndrome and other dysraphic syndromes / Robin L. Gilmore, Sun Ik Lee, and John Walsh -- Conservative versus surgical treatment and prognostic evaluation for tethered cord syndrome / Shokei Yamada ... [et al.].
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  • An historical introduction to porphyrin and chlorophyll synthesis / Michael R. Moore -- Biosynthesis of 5-aminolevulinic acid / Dieter Jahn and Dirk W. Heinz -- 5-aminolaevulinic acid dehydratase, porphobilinogen deaminase and uroporphyrinogen III synthase / Heidi L. Schubert, Peter T. Erskine and Jonathan B. Cooper -- Transformation of uroporphyrinogen III into protohaem / Johanna E. Cornah and Alison G. Smith -- Inherited disorders of haem synthesis: the human porphyrias / Michael N. Badminton and George H. Elder -- Heme degradation: mechanistic and physiological implications / Angela Wilks -- Regulation of mammalian heme biosynthesis / Amy E. Medlock and Harry A. Dailey -- Tetrapyrroles in photodynamic therapy / David I. Vernon and Ian Walker -- Heme transport and incorporation into proteins / Linda Thöny-Meyer -- Heme and hemoproteins / Andrew W. Munro ... [et al.] -- Novel heme-protein interactions: some more radical than others / Ann Smith -- Synthesis and role of bilins in photosynthetic organisms / Nicole Frankenberg-Dinkel and Matthew J. Terry -- Phytochromes: bilin-linked photoreceptors in bacteria and plants / Matthew J. Terry and Alex C. McCormac -- Biosynthesis of chlorophyll and bacteriochlorophyll / Derren J. Heyes and C. Neil Hunter -- Regulation of tetrapyrrole synthesis in higher plants / Matthew J. Terry and Alison G. Smith -- Regulation of the late steps of chlorophyll biosynthesis / Wolfhart Rudiger -- Chlorophyll breakdown / Bernhard Kräutler -- Vitamin B12: biosynthesis of the corrin ring / Ross M. Graham, Evelyne Deery and Martin J. Warren -- Conversion of cobinamide into coenzyme B12 / Jorge C. Escalante-Semerena ... [et al.] -- The regulation of cobalamin biosynthesis / Jeffrey G. Lawrence -- Coenzyme B12-catalyzed radical isomerizations / Dominique Padovani and Ruma Banerjee -- Biosynthesis of siroheme and coenzyme F430 / Martin J. Warren, Evelyne Deery and Ruth-Sarah Rose -- Role of coenzyme F430 in methanogenesis / Evert C. Duin -- The role of siroheme in sulfite and nitrite reductases / M. Elizabeth Stroupe and Elizabeth D. Getzoff -- The role of heme d1 in denitrification / Stuart J. Ferguson.
  • Tetraspanins 2013
    Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains.
  • This book combines clear explanatory text with a wealth of images of ECG recordings in order to provide an accessible, up-to-date source of information and guide to interpretation for all professionals seeking to increase their expertise in electrocardiography. ECG results are presented and discussed for a wide range of conditions, including all forms of arrhythmia, Wolff-Parkinson-White syndrome, bundle branch blocks, ischemic cardiomyopathy, atrial and ventricular enlargement, pericardial and myocardial diseases, diseases of the pulmonary circulation, and post pacemaker implantation. Normal ECG findings are fully described, and helpful introductory information is included on the principles of electrophysiology. The practically oriented text accompanying the ECG recordings covers both electrophysiological and clinical aspects. More than 100 years after its first use by Willem Einthoven, electrocardiography continues to be the first diagnostic tool applied in most cardiac patients. This text atlas provides a sound basis for the correct ECG interpretation essential for appropriate patient management.
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    v. 1. Head and neck -- v. 2. Chest -- v. 3. Abdomen -- v. 4. Bones, joints and soft tissues.
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    v. 1. Principles and methods. Cornea and anterior chamber -- v. 2. Lens and zonule -- v.3. Iris, vitreous body, conjunctiva.
  • Now fully revised and updated, Textbook of Adult Emergency Medicine provides clear and consistent coverage of this rapidly evolving specialty. Building on the success of previous editions, it covers all the major topics that present to the trainee doctor in the emergency department. It will also prove invaluable to the range of other professionals working in this setting - including nurse specialists and paramedics - who require concise, highly practical guidance, incorporating latest best practice and current guidelines. For the first time this edition now comes with a complete and enhanced electronic version, providing a richer learning experience and making rapid reference easier than ever before, anytime, anywhere. Updates throughout reflect latest practice developments, curricula requirements and essential guidelines Key point boxes highlight topic 'essentials' as well as controversial areas of treatment An expanded list of leading international contributors ensures comprehensive coverage and maximizes worldwide relevance New and enhanced coverage of important and topical areas - including latest imaging in emergency medicine; organ donation; massive transfusion protocols; medico legal issues; patient safety and quality measures All new accompanying electronic version, including procedure videos and self-assessment materials to check your understanding and aid exam preparation.
  • Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases.
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    Part I: Structure of macromolecules -- 1. Eukaryotic Cell Structure -- 2. DNA and RNA: Composition and Structure -- 3. Proteins I: Composition and Structure -- Part II: Transmission of information -- 4. DNA Replication, Recombination, and Repair -- 5. RNA: Transcription and RNA Processing -- 6. Protein Synthesis: Translation and Posttranslational Modifications -- 7. Recombinant DNA and Biotechnology -- 8. Regulation of Gene Expression -- Part III: Functions of proteins -- 9. Proteins II: Structure-Function Relationships in Protein Families -- 10. Enzymes: Classification, Kinetics, and Control -- 11. The Cytochromes P450 and Nitric Oxide Synthases -- 12. Biological Membranes: Structure, Receptors, and Solute Transport -- 13. Fundamentals of Signal Transduction -- Part IV: Metabolic pathways and their control -- 14. Bioenergetics, Mitochondria, and Oxidative Metabolism -- 15. Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control -- 16. Carbohydrate Metabolism II: Special Pathways and Glycoconjugates -- 17. Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols -- 18. Lipid Metabolism II: Pathways of Metabolism of Special Lipids -- 19. Amino Acid and Heme Metabolism -- 20. Purine and Pyrimidine Nucleotide Metabolism -- 21. Metabolic Interrelationships -- 22. Biochemistry of Hormones -- Part V: Physiological processes -- 23. Molecular Cell Biology -- 24. Cell Cycle, Programmed Cell Death, and Cancer -- 25. Digestion and Absorption of Basic Nutritional Constituents -- 26. Vitamins and Minerals: Requirements and Function -- 27. Macronutrients: Metabolic Effects and Health Implications -- Appendix: Review of Organic Chemistry -- Glossary -- Index.
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    Part I. Background -- Accomplishments in cancer epidemiology / Brian MacMahon -- Measures and estimates of cancer burden / Pagona Lagiou, Johanna Adami, and Dimitrios Trichopoulos -- The origin of cancer /Jeffrey Ecsedy and David Hunter -- Genetic epidemiology of cancer / Christopher Haiman and David Hunter -- Biomarkers in cancer epidemiology / Paolo Boffetta and Dimitrios Trichopoulos -- Concepts in cancer epidemiology and etiology / Pagona Lagiou, Dimitrios Trichopoulos, and Hans-Olov Adami -- Part II. Cancer epidemiology by site-specific cancers -- Oral and pharyngeal cancer / Paul Brennan, Lorelei Mucci, and Hans-Olov Adami -- Nasopharyngeal carcinoma / Ellen Chang and Hans-Olov Adami -- Esophageal cancer / Olof Nyrén and Hans-Olov Adami -- Stomach cancer / Olof Nyrén and Hans-Olov Adami -- Colorectal cancer / John D. Potter and David Hunter -- Cancer of the liver and biliary tract / Sherri Stuver and Dimitrios Trichopoulos -- Pancreatic cancer / Anders Ekbom and Dimitrios Trichopoulos -- Cancer of the lung, larynx, and pleura / Paolo Boffetta and Dimitrios Trichopoulos -- Skin cancer / Adèle Green, Jolieke van der Pols, and David Hunter -- Breast cancer / Susan Hankinson, Rulla Tamimi, and David Hunter -- Cervical cancer / Nathalie Ylitalo, Sherri Stuver, and Hans-Olov Adami -- Endometrial cancer / Immaculata DeVivo, Ingemar Persson, and Hans-Olov Adami -- Ovarian cancer / Penelope Webb, Dorota Gertig, and David Hunter -- Prostate cancer / Lorelei A. Mucci, Lisa B. Signorello, and Hans-Olov Adami -- Testicular cancer / Lorenzo Richiardi, Rulla Tamimi, and Hans-Olov Adami -- Urinary bladder cancer / Manolis Kogevinas, Montserrat Garcia-Closas, and Dimitrios Trichopoulos -- Kidney cancer / Eunyoung Cho, Per Lindblad, and Hans-Olov Adami -- Brain cancer / David A. Savitz and Dimitrios Trichopoulos -- Thyroid cancer / Per Hall and Hans-Olov Adami -- Hodgkin lymphoma / Mads Melbye, Henrik Hjalgrim, and Hans-Olov Adami -- Non-hodgkin lymphoma / Mads Melbye, Karin Ekström Smedby, and Dimitrios Trichopoulos -- Leukemias / Eleni Petridou, Apostolos Pourtsidis, and Dimitrios Trichopoulos.
  • Catheter-based interventions have evolved to address a variety of needs through innovation and clinical evidence.The field of interventional cardiology and interventional vascular medicine now comprises the dominant diagnostic and therapeutic field within cardiovascular medicine, and continues to grow in terms of patients managed and physicians trained. Given the vast expansion of technologies, techniques, and the clinical evidence base, it can be challenging for the practicing clinician, fellow-in-training, or technology developer to maintain general knowledge of the interventional cardiovascular field.The Textbook of Cardiovascular Intervention is intended to provide a practical, comprehensive and compact text on interventional cardiology for the current, rapidly evolving practice environment. It will appeal to fellows, residents and physicians in cardiology, interventional cardiology, cardiothoracic and vascular surgery, vascularand endovascular medicine, neurointerventional radiology and surgery, emergency medicine and intensive care.
  • Atherosclerotic biology and epidemiology of disease -- Diet and nutritional issues -- Obesity and metabolic syndrome -- Diabetes -- Lipid disorders -- Exercise and physical activity -- Hypertension: context and management -- Smoking -- Estrogen, female gender, and heart disease -- Ethanol and the heart -- Other risk factors for coronary artery disease -- Behavioral cardiology and heart disease -- Cardiac rehabilitation and secondary prevention -- An integrated approach to risk factor modification -- The history -- Physical examination -- Chronic stable coronary disease -- Unstable angina: ischemic syndromes -- Acute myocardial infarction: early diagnosis and management -- Acute myocardial infarction: complications -- Post-Myocardial infarction management -- Mitral valve disease -- Aortic valve disease -- Acquired tricuspid and pulmonary valve disease -- Prosthetic valve disease -- Infective endocarditis -- Diseases of the pericardium, restrictive cardiomyopathy, and diastolic dysfunction -- Pulmonary hypertension -- Hypertrophic cardiomyopathy -- Congenital heart disease -- The heart and pregnancy -- Women and heart disease -- The elderly and aging -- End-of-life care -- The heart and other organ systems -- Endocrine systems and the heart -- Hematologic disorders and the heart -- The heart and the renal system -- Cardiac manifestations of selected neurologic disorders -- Cardiovascular manifestations of rheumatic diseases -- The heart and infectious diseases -- Substance abuse and the heart -- The athlete's heart -- Cardiac trauma -- Cardiac tumors -- Clinical pharmacology for the cardiologist -- Perioperative anesthetic considerations in noncardiac surgery for those at high risk of cardiovascular disease -- Medical economics in cardiovascular medicine -- Considerations in the design, conduct, and interpretation of quantitative clinical evidence -- Databases in cardiology -- Quality of care and medical errors in cardiovascular disease -- Principles of imaging -- Plain film examination of the chest -- Exercise electrocardiography -- Transthoracic echocardiography -- Stress echocardiography -- Doppler echocardiography -- Transesophageal echocardiography -- Imaging techniques in nuclear cardiology -- Cardiovascular magnetic resonance imaging -- Positron emission tomography -- Computed tomography of the heart -- Mechanisms of cardiac arrhythmias -- Genetics of arrhythmias -- Electrocardiography -- Ambulatory and signal-averaged electrocardiography and t-wave alternans -- Electrophysiologic testing -- Bradycardias: sinus nodal dysfunction and atrioventricular conduction disturbances -- Atrial fibrillation -- Atrial flutter -- Atrioventricular nodal-dependent tachycardias and preexcitation -- Ventricular tachycardia -- Sudden cardiac death and implantable cardioverter-defibrillators -- Sudden cardiac death in the young: the impact of inherited cardiovascular disease -- Cardiopulmonary resuscitation -- Arrhythmias in congenital heart disease -- Syncope -- Antiarrhythmic drugs -- Catheter ablation therapy for arrhythmias -- Cardiac pacemakers -- Left ventricular dyssynchrony and cardiac resynchronization therapy-- Coronary angiography -- Cardiac catheterization and hemodynamic assessment -- Percutaneous coronary intervention -- Percutaneous cardiac procedures -- Coronary artery bypass surgery -- Approaches to the patient with prior bypass surgery -- Percutaneous valve dilatations -- Catheter interventions in congenital heart disease -- Global pandemic of heart failure -- Pathophysiology of the heart failure clinical syndrome -- Acute heart failure -- Chronic heart failure management -- Diagnosis and medical treatment of inflammatory cardiomyopathy -- Nonischemic cardiomyopathies -- Cardiac transplantation and mechanical circulatory support -- surgical approaches for heart failure -- Prevention of heart failure -- General techniques in molecular cardiology -- Molecular genetics -- Genetic factors in atherosclerosis -- Genetic studies of myocardial and vascular disease -- Gene therapy -- Myocyte structure and function -- Signal transduction pathways of the heart -- Molecular basis of heart development -- Stem cell therapy for ischemic heart disease -- The biology of restenosis -- Therapeutic angiogenesis -- Diseases of the pulmonary vasculature -- Diseases of the aorta -- Noninvasive assessment of peripheral vascular disease -- Cerebrovascular disease -- Disease of peripheral vessels -- Renal artery disease -- Venous thromboembolism.
  • This 5th Edition enables you to use echocardiography to its fullest potential in your initial diagnosis, decision making, and clinical management of patients with a wide range of heart diseases. World-renowned cardiologist Dr. Catherine M. Otto helps you master what you need to know to obtain the detailed anatomic and physiologic information that can be gained from the full range of echo techniques, from basic to advanced. Acquire a solid foundation in the essentials of advanced echocardiography techniques such as contrast echo, 3D echo, myocardial mechanics, and intraoperative transesophageal echocardiography. Fully understand the use of echocardiography and its outcomes with key points that identify the must-know elements in every chapter, and state-of-the-art echo images complemented by full-color comparative drawings of heart structures. Familiarize yourself with new ASE recommendations for echocardiographic assessment of the right heart and 3D echocardiography, including updated tables of normal measurements.
  • "The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook - inspired by the postgraduate degree program at the University of Oxford - guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology"--Provided by publisher.
  • Introduction to hemodynamic assessment in the cardiac catheterization laboratory / Michael Ragosta -- Normal waveforms, artifacts, and pitfalls / Michael Ragosta -- Cardiac outputs and shunts / Vishal Aurora -- Mitral valve disorders / Michael Ragosta -- Aortic valve disease / Michael Ragosta -- Hypertrophic cardiomyopathy and related conditions / Michael Ragosta -- Right-sided heart disorders: hemodynamics of the tricuspid and pulmonic valves and pulmonary hypertension / Michael Ragosta -- Pericardial disease and restrictive cardiomyopathy / Michael Ragosta -- Shock, heart failure, and related disorders / Michael Ragosta -- Complications of acute myocardial infarction / Brandon Brown -- Congenital heart disease / Rajan A.G. Patel and D. Scott Lim -- Coronary hemodynamics / Michael Ragosta -- Advanced hemodynamic assessment of ventricular function / D. Scott Lim and Howard P. Gutgesell -- Miscellaneous hemodynamic conditions / Michael Ragosta.
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    Principles and practice -- Work sectors and special populations -- Occupational diseases and injuries -- Hazards in the workplace and the environment -- Policy, regulation and control.
  • V. 1, section 1. Genetic disorders / Bruce R. Korf ; section 2. Neonatology / Martin Keszler ; section 3. Inborn errors of metabolism / Pinar T. Ozand ; section 4. Developmental, learning and behavioral disorders / Pamela High and Yvette Yatchmink -- v. 2, section 5. Pediatric nutrition / Hisham M. Nazer ; section 6. Infectious diseases / Richard J. Whitley ; section 7. Primary immunodeficiency disorders / Harb A. Harfi ; section 8. Allergic disorders / Harb A. Harfi -- v. 3, section 9. Disorders of the skin / Zbigniew Ruszczak ; section 10. Rheumatology / Alberto Martini ; section 11. Oral and craniofacial disorders / J. Burton Douglass ; section 12. Gastrointestinal and liver disorders / Hisham M. Nazer -- v. 4, section 13. Respiratory disorders / Gabriel G. Haddad ; section 14. Cardiology / Mark B. Lewin ; section 15. Critical care / Abdul-Rahman M. Abu-Taleb and Peter N. Cox ; section 16. Pediatric burns / Fuad Hashem ; section 17. Pediatric poisoning / Khaled M. Al-Haidari and Nada S. Al-Qadheeb ; section 18. Disturbances in acid-base and electrolytes disorders / F. Bruder Stapleton ; section 19. Kidney and urinary tract disorders / F. Bruder Stapleton -- v. 5, section 19. Kidney and urinary tract disorders / F. Bruder Stapleton ; section 20. Blood diseases / Michael Recht ; section 21. Pediatric oncology / H. Stacy Nicholson ; section 22. Neurology / Generoso G. Gascon -- v. 6, section 22. Neurology / Generoso G. Gascon ; section 23. Endocrine disorders / Khalid Hussain ; section 24. Adolescent medicine / Leslie R. Walker ; section 25. Pediatric orthopedics / Craig P. Eberson ; section 26. Pediatric otolaryngology / Mohamed O. Abuzeid ; section 27. Pediatric ophthalmology / Selwa A.F. Al-Hazzaa ; section 28. Pediatric surgery / Thomas F. Tracy ; section 29. Drug dosing in pediatrics / Kristine A. Parbuoni.
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  • This reference - acclaimed for its success in bridging the gap between medical and surgical critical care - now features an even stronger focus on patient outcomes, equipping you with the proven, evidence-based guidance you need to successfully overcome a full range of practice challenges. Inside, you'll find totally updated coverage of vital topics, such as coagulation and apoptosis in certain critical care illnesses, such as acute lung injury and adult respiratory distress syndrome; sepsis and other serious infectious diseases; specific organ dysfunction and failure; and many other vital topics. Effectively apply the latest techniques and approaches with totally updated coverage of the importance of coagulation and apoptosis in certain critical care illnesses, such as acute lung injury and adult respiratory distress syndrome; sepsis and other serious infectious diseases; specific organ dysfunction and failure; and many other vital topics.
  • Synopsis: Stay up to date with the rapidly changing field of medical sonography! Heavily illustrated and extensively updated to reflect the latest developments in the field, Textbook of Diagnostic Sonography, 7th Edition equips you with an in-depth understanding of general/abdominal and obstetric/gynecologic sonography, the two primary divisions of sonography, as well as vascular sonography and echocardiography. Each chapter includes patient history, normal anatomy (including cross-sectional anatomy), ultrasound techniques, pathology, and related laboratory findings, giving you comprehensive insight drawn from the most current, complete information available. Full-color presentation enhances your learning experience with vibrantly detailed images. Pathology tables give you quick access to clinical findings, laboratory findings, sonography findings, and differential considerations. Sonographic Findings highlight key clinical information. Key terms and chapter objectives help you study more efficiently. Review questions on a companion Evolve website reinforce your understanding of essential concepts. New chapters detail the latest clinically relevant content in the areas of: Essentials of Patient Care for the Sonographer; Artifacts in Image Acquisition; Understanding Other Imaging Modalities; Ergonomics and Musculoskeletal Issues in Sonography; 3D and 4D Evaluation of Fetal Anomalies; More than 700 new images (350 in color) clarify complex anatomic concepts. Extensive content updates reflect important changes in urinary, liver, musculoskeletal, breast, cerebrovascular, gynecological, and obstetric sonography.
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    The origins of family medicine -- Principles of family medicine -- Illness in the community -- A profile of family practice -- Philosophical and scientific foundations of family medicine -- Illness, suffering, and healing -- Doctor-patient communication -- Clinical method -- The enhancement of health and the prevention of disease -- The family in health and disease -- Acute sore throat -- Headache -- Fatigue -- Hypertension -- Diabetes -- Home care -- Records -- Consultation and referral -- The health professions -- The community service network -- Alternative or complementary medicine -- Practice management -- Continuing self-education -- Research in family practice.
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  • This ninth edition of the Textbook of Family Medicine, edited by Drs. Robert E. Rakel and David P. Rakel, remains your #1 choice for complete guidance on the principles of family medicine, primary care in the community, and all aspects of clinical practice. Ideal for both residents and practicing physicians, this medical reference book includes evidence-based, practical information to optimize patient care and prepare you for the ABFM exam. A clean, quick-reference layout makes it easy for you to put information to work immediately in your practice.
  • Imaging contrast agents and pharmacoradiology -- Barium studies : single and double contrast -- Pictorial glossary of double-contrast radiology -- Ultrasound of the hollow viscera -- Multidetector computed tomography of the gastrointestinal tract : principles of interpretation -- Magnetic resonance imaging of the hollow viscera -- Positron emission tomography and computed tomography of the hollow viscera -- Angiography and interventional radiology of the hollow viscera -- Abdominal computed tomography angiography -- Magnetic resonance angiography of the mesenteric vasculature -- Abdomen : normal anatomy and examination techniques -- Gas and soft tissue abnormalities -- Abdominal calcifications -- Pharynx : normal anatomy and examination techniques -- Abnormalities of pharyngeal function -- Structural abnormalities of the pharynx -- Barium studies of the upper gastrointestinal tract -- Motility disorders of the esophagus -- Gastroesophageal reflux disease -- Infectious esophagitis -- Other esophagitides -- Benign tumors of the esophagus -- Carcinoma of the esophagus -- Other malignant tumors of the esophagus -- Miscellaneous abnormalities of the esophagus -- Abnormalities of the gastroesophageal junction -- Postoperative esophagus -- Esophagus : differential diagnosis -- Peptic ulcers -- Inflammatory conditions of the stomach and duodenum -- Benign tumors of the stomach and duodenum -- Carcinoma of the stomach and duodenum -- Other malignant tumors of the stomach and duodenum -- Miscellaneous abnormalities of the stomach and duodenum -- Postoperative stomach and duodenum -- Stomach and duodenum : differential diagnosis -- Barium examinations of the small intestine -- Computed tomography enterography -- Computed tomography enteroclysis -- Magnetic resonance enterography -- Crohn's disease of the small bowel -- Inflammatory disorders of the small bowel other than Crohn's disease -- Malabsorption -- Benign tumors of the small bowel -- Malignant tumors of the small bowel -- Small bowel obstruction -- Vascular disorders of the small intestine -- Postoperative small bowel -- Miscellaneous abnormalities of the small bowel -- Small intestine : differential diagnosis -- Barium studies of the colon -- Functional imaging of anorectal and pelvic floor dysfunction -- Computed tomography colonography -- Magnetic resonance colonography -- Diverticular disease of the colon -- Diseases of the appendix -- Ulcerative and granulomatous colitis : idiopathic inflammatory bowel disease -- Other inflammatory conditions of the colon -- Polyps and colon cancer -- Other tumors of the colon -- Polyposis syndromes -- Miscellaneous abnormalities of the colon -- Postoperative colon -- Colon : differential diagnosis -- Computed tomography of the solid abdominal organs -- Ultrasound examination of the solid abdominal viscera -- Magnetic resonance imaging of the solid parenchymal organs -- Positron emission tomography/computed tomography of the solid parenchymal organs -- Diffusion-weighted imaging of the abdomen -- Perfusion computed tomography and magnetic resonance imaging in the abdomen and pelvis -- Techniques of percutaneous tissue acquisition -- Abdominal abscess -- Gallbladder and biliary tract : normal anatomy and examination techniques -- Endoscopic retrograde cholangiopancreatography -- Magnetic resonance cholangiopancreatography -- Anomalies and anatomic variants of the gallbladder and biliary tract -- Cholelithiasis, cholecystitis, choledocholithiasis, and hyperplastic cholecystoses -- Interventional radiology of the gallbladder and biliary tract -- Neoplasms of the gallbladder and biliary tract -- Inflammatory disorders of the biliary tract -- Postsurgical and traumatic lesions of the biliary tract -- Gallbladder and biliary tract : differential diagnosis -- Liver : normal anatomy and examination techniques -- Interventional radiology of the liver -- Anomalies and anatomic variants of the liver -- Benign tumors of the liver -- Malignant tumors of the liver -- Focal hepatic infections -- Diffuse liver disease -- Vascular disorders of the liver and splanchnic circulation -- Hepatic trauma, surgery, and liver-directed therapy -- Liver transplantation imaging -- Liver : differential diagnosis -- Pancreas : normal anatomy and examination techniques -- Interventional radiology of the pancreas -- Anomalies and anatomic variants of the pancreas -- Pancreatitis -- Pancreatic neoplasms -- Pancreatic trauma and surgery -- Pancreatic transplantation imaging -- Pancreas : differential diagnosis -- Spleen : normal anatomy and examination techniques -- Angiography and interventional radiology of the spleen -- Anomalies and anatomic variants of the spleen -- Benign and malignant lesions of the spleen -- Splenic trauma and surgery -- Spleen : differential diagnosis -- Anatomy and imaging of the peritoneum and retroperitoneum -- Pathways of abdominal and pelvic disease spread -- Ascites and peritoneal fluid collections -- Mesenteric and omental lesions -- Hernias and abdominal wall pathology -- Applied embryology of the gastrointestinal tract -- Neonatal gastrointestinal radiology -- Diseases of the pediatric esophagus -- Diseases of the pediatric stomach and duodenum -- Diseases of the pediatric small bowel -- Diseases of the pediatric colon -- Diseases of the pediatric gallbladder and biliary tract -- Diseases of the pediatric liver -- Diseases of the pediatric pancreas -- Diseases of the pediatric spleen -- Diseases of the pediatric abdominal wall, peritoneum, and mesentery -- The acute abdomen -- Gastrointestinal hemorrhage -- Abdominal trauma -- Monitoring gastrointestinal tumor response to therapy.
  • Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. It is innovative, up to date, and practical. The links with particular occupations are explained, the various diagnostic tests are presented, and the role of different topical and systemic treatments is clearly described. The authors are world leaders in the field. The Textbook of Hand Eczema reflects a new era in hand dermatitis and will be invaluable for all who deal with the condition in their clinical practice.
  • Influenza: perspective -- Human influenza: one health, one world -- Influenza pandemics: history and lessons learned -- Structure and replication -- Structure, disassembly, assembly, and budding of influenza viruses -- The virus genome and its replication -- Influenza glycoproteins: hemagglutinin and neuraminidase -- Proton channels of influenza A and B viruses -- The NS1 protein: a master regulator of host and viral functions -- Structure and function of the influenza virus replication machinery and PB1-F2 -- The genome and its manipulation: recovery of the 1918 virus and vaccine virus generation -- Pathogenesis -- Evolution and ecology of influenza viruses -- Ecology and evolution of influenza viruses in wild and domestic birds -- Influenza in swine -- Equine/canine/feline/seal influenza -- Emergence and evolution of the 1918, 1957, 1968, and 2009 pandemic virus strains -- Epidemiology and surveillance -- Influenza surveillance and laboratory diagnosis -- Epidemiology of influenza -- Immunology of influenza -- Innate immunity -- Antibody-mediated immunity -- Cell-mediated immunity -- Vaccines and vaccine development -- Immunogenicity, efficacy of inactivated/live virus seasonal and pandemic vaccines -- New approaches to vaccination -- Control of influenza in animals -- Influenza vaccine production -- Clinical aspects and antivirals -- Human influenza: pathogenesis, clinical features, and management -- Antivirals: targets and use -- The control of influenza and cost-effectiveness of interventions -- Applications of quantitative modeling to influenza virus transmission dynamics, antigenic and genetic evolution, and molecular structure -- Pandemic preparedness and response -- Influenza: the future -- The outbreak of H7N9.
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    Evolution of integrative medicine and implications for mental health care -- Philosophical problems -- Paradigms in medicine, psychiatry, and integrative medicine -- Foundations of clinical methodology in integrative medicine -- History taking, assessment, formulation in integrative mental health care -- Starting and maintaining integrative treatment in mental health care -- Symptom-focused integrative mental health care -- Integrative management of depressed mood -- Integrative management of mania and cyclic mood changes -- Integrative management of anxiety -- Integrative management of psychosis -- Integrative management of dementia and mild cognitive impairment -- Integrative management of substance abuse and dependence -- Integrative management of disturbances of sleep and wakefulness.
  • "The Textbook of Interdisciplinary Pediatric Palliative Care, by Drs. Joanne Wolfe, Pamela Hinds, and Barbara Sourkes, aims to inform interdisciplinary teams about palliative care of children with life-threatening illness. It addresses critical domains such as language and communication, symptoms and quality of life, and the spectrum of life-threatening illnesses in great depth. This comprehensive product takes a first-of-its-kind team approach to the unique needs of critically ill children. It shows how a collaborative, interdisciplinary care strategy benefits patients and their families. If you deal with the complex care of critically ill children, this reference provides a uniquely integrated perspective on complete and effective care."--Publisher's website.
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    The historical origins of modern international health -- International health agencies, activities, and other actors -- The political economy of health and development -- What do we know, what do we need to know, and why it matters : data on health -- Epidemiologic profiles of global health and disease -- Societal determinants of health and social inequalities in health -- Health under crisis -- Globalization, trade, work, and health -- Health and the environment -- Health economics and the economics of health -- Understanding and organizing health care systems -- Toward healthy societies : from ideas to action -- Doing international health.
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  • Ideal for cardiologists, surgeons, and referring physicians who need a clinical guide to interventional procedures, Textbook of Interventional Cardiology focuses on the latest treatment protocols for managing heart disorders at every level of complexity. In this updated edition, Dr. Topol continues to bring together experts in the field who present the current state of knowledge and clinical practice in interventional cardiology, including cutting-edge theories, trends, and applications of diagnostic and interventional cardiology, as well as peripheral vascular techniques and practices.
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  • Ch. 1. From nanotechnology to nanoneuroscience/nanoneurosurgery and nanobioelectronics : a historical review of milestones / Vicky Yamamoto ... [et al.] -- ch. 2. Nanoneurology and nanoneurosurgery / Geoffrey S. F. Ling, Robbin Miranda, and Gill Pratt -- ch. 3. Nanopolymers and nanoconjugates for central nervous system diagnostics and therapies / Giancarlo Suffredini and Lucien M. Levy -- ch. 4. Micelles and liposomes : lipid nanovehicles for intracerebral drug delivery / Massimo S. Fiandaca and Krystof S. Bankiewicz -- ch. 5. Peptide and protein-based nanoparticles / Ayaz M. Khawaja and John D. Heiss -- ch. 6. Endohedral metallofullerenes, iron oxide agents, and gold nanoparticles for brain imaging / Martina A. McAteer and Robin P. Choudhury -- ch. 7. Carbon nanoplatforms and their application for neurological disorders / Houman Badrzadeh, Peyman Tashkandi, Michelle Knosp, and Babak Kateb -- ch. 8. Dendrimers / Ayaz M. Khawaja and John D. Heiss Chapter -- ch. 9. Ligand-based targeting of therapeutic and imaging agents for cancer / Qimeng Quan, Seulki Lee, and Xiaoyuan Chen -- ch. 10. Immune-based targeting in cancer / Dwain K. Irvin, Chirag G. Patil, and Keith L. Black -- ch. 11. Directed drug convection using magnetic nanoparticles as therapeutic carriers : meeting the challenge of specific brain pharmacotherapeutics, non-ligand-based central nervous system targeting, including magnetic focusing / David F. Moore ... [et al.] -- ch. 12. Intralesional and intraparenchymal convection-enhanced delivery of nanoparticles / Tatsuhiro Fujii ... [et al.] -- ch. 13. Transport of nanoparticles across blood-brain barrier / Robert T. Wicks, Zev A. Binder, and Alessandro Olivi -- ch. 14. Nanomedicine treatment strategies that exploit unique characteristics of tumor vasculature and microenvironment / Jun Wu, Tatsuhiro Fujii, and Mike Y. Chen -- ch. 15. Focused ultrasound for noninvasive neuromodulation / Martin O. Culjat ... [et al.] -- ch. 16. Nanosensors / J. Matthew Dubach and Heather A. Clark -- ch. 17. Implantable infusion pumps incorporating nanotechnology / Ellis Meng, Tuan Hoang, and Uttam Sinha -- ch. 18. Nanostructured surfaces for intracerebral neurotransmitter recording / David A. Price ... [et al.] -- ch. 19. Therapy for neuronopathic lysosomal storage diseases / Ayaz M. Khawaja, John D. Heiss, and Roscoe O. Brady -- ch. 20. Nanotechnology for cerebral aneurysm treatment / Jean Paul Allain, Teodoro Tigno, and Rocco Armonda -- ch. 21. Improving treatment of stroke through nanotechnology / Francesca Nicholls ... [et al.] -- ch. 22. Molecular medical devices for nanoneurosurgery / Rutledge Ellis-Behnke -- ch. 23. Applications of nanotechnology in epilepsy / Paul R. Carney -- ch. 24. Applications of nanotechnology to diseases of the spine / Bryn S. Moore and Steven A. Toms -- ch. 25. Nanoparticle-based treatment and imaging of brain tumors : potentials and limitations / Bong-Seop Lee ... [et al.] -- ch. 26. Tumor-targeted nanodrugs for treatment of primary brain tumors / Joseph T. Cheatle and Michele R. Aizenberg -- ch. 27. Application of nanotechnology in the diagnosis and treatment of brain metastasis / Joel C. Sunshine ... [et al.] -- ch. 28. Nanotechnology in extra-axial and pituitary tumors / Aimee Two, J. Peter Gruen, and Gabriel Zada -- ch. 29. Using nanoparticles in diagnosis and treatment of CNS infection / Zion Zibly, Cody D. Schlaff, and John D. Heiss -- ch. 30. Applications of nanotechnology in movement disorders / Patrick Pezeshkian ... [et al.] -- ch. 31. Nanomedicine in demyelinating disease : application to diagnosis and therapy in multiple sclerosis / Emily C. Leibovitch and Steven Jacobson -- ch. 32. Applications of nanotechnology in degenerative disorders of the brain / Ayaz M. Khawaja and John D. Heiss -- ch. 33. Brain-machine interface and rehabilitation / Martin Pham, Alexander Taghva, and Ali R. Rezai -- ch. 34. Nanobioelectronics for noninvasive neuronal therapy / Evangelia Hondroulis, Jairo Nelson, and Chen-Zhong Li -- ch. 35. In vitro and in vivo techniques to assess neurotoxicity of nanoparticles / Thomas Birngruber ... [et al.] -- ch. 36. Nanorobotics for neurosurgery / Robbin Miranda, Gill Pratt, and Geoffrey S. F. Ling -- ch. 37. Imaging and tracking therapeutic cells with nanoparticles / Gang Niu and Joseph A. Frank -- ch. 38. Micro- and nanotechnology in nerve repair / Ali C. Ravanpay and Michel Kliot -- ch. 39. Nanotechnology : applications to pediatric neurosurgery / Giancarlo Suffredini and Robert F. Keating -- ch. 40. Food and drug administration regulatory framework for nanodrugs and nanodevices and the combination / Vicky Yamamoto -- ch. 41. Nanoneuroscience and nanoneurosurgery : a key component of President Obama's brain mapping initiative / Babak Kateb ... [et al.].
  • Covering preventive, non-invasive, and natural treatments, this 4th Edition offers more than just alternative medicine. It promotes an integrated practice that can utilize natural medicine, traditional Western medicine, or a combination of both in a comprehensive, scientific treatment plan. Based on a combination of philosophy and clinical studies, this book helps you provide health care that identifies and controls the underlying causes of disease, is supportive of the body's own healing processes, and is considerate of each patient's unique biochemistry. Internationally known authors Joseph Pizzorno and Michael Murray include detailed pharmacologic information on herbs and supplements, plus evidence-based coverage of diseases and conditions to help you make accurate diagnoses and provide effective therapy. 13 useful appendices offer quick lookup of frequently used charts, handouts, and information. New chapters are included on hot topics such as female infertility, medicinal mushrooms, natural products and quality control, pregnancy health and primary prevention, and Vitamin K; new appendices include a supplier certification questionnaire and cervical escharotics treatment. Thorough updates ensure that you use only the most current research and provide the most effective treatment of patients. Tabs in Specific Health Problems section separate more than 70 alphabetized diseases/conditions. One convenient volume replaces the cumbersome two-volume set for easy, convenient reference.
  • 2009 ClinicalKey
    Part I: The kidney as an endocrine organ -- Section I: Erythropoietin -- Erythropoietin: an historical overview of physiology, molecular biology and gene regulation / David R. Mole, Peter J. Ratcliffe -- Erythropoiesis: the roles of erythropoietin and iron / Herbert Y. Lin -- Extra-hematopoietic action of erythropoietin / Zheqing Cal, Gregg L. Semenza -- Development of recombinant erythropoietin and erythropoietin analogs / Iain C. Macdougall -- Erythropoietin, anemia and kidney disease / Ajay K. Singh ... [et al.] -- Section II: Vitamin D, PTH and novel regulators of phosphate -- Vitamin D and the kidney: introduction and historical perspective / Tejas Patel, Ajay K. Singh --- Vitamin D: molecular biology and gene regulation / Adriana S. Dusso, Alex J. Brown -- Endocrine regulation of phosphate homeostasis / Harald Jüppner, Anthony A. Portale -- Section III: Renin-Angiotensin -- The history of the renin-angiotensin system / Joel Menard -- Molecular biology of renin and regulation of its gene / Timothy L. Reudelhuber, Daniel F. Catanzaro -- Physiology and regulation of the renin-angiotensin-aldosterone system / Robert M. Carey, Shetal H. Padia -- The renin-angiotensin-aldosterone system and the kidney / Benjamin Ko, George Bakris -- The renin-angiotensin system and the heart / Aaron J. Trask, Carlos M. Ferrario -- Renin-angiotensin blockage: therapeutic agents / Domenic A. Sica -- Part II: The kidney as a hormonal target -- Section IV: Antidiuretic hormone -- Vasopressin in the kidney: historical aspects / Lynn E. Schlanger, Jeff M. Sands -- Molecular biology and gene regulation of vasopressin / Swasti Tiwari, Carolyn A. Ecelbarger -- Vasopressin antagonists in physiology and disease / Tomas Berl, Robert W. Schrier -- Diabetes insipidus and SIADH / Michael L. Moritz, Juan Carlos Ayus -- Section V: The atrial peptides -- ANP, BNP and CNP: physiology and pharmacology of the cardiorenal axis / Candace Y. W. Lee, John C. Burnett Jr -- Section VI: Aldosterone -- Aldosterone: history and introduction / John Coghlan, James F. Tait -- Aldosterone receptors and their renal effects: molecular biology and gene regulation / Celso E. Gomez-Sanchez, Elise P. Gomes-Sanchez, Mario Galigniana -- Aldosterone and its cardiovascular effects / Rajesh Garg, Gail K. Adler -- Regulation of aldosterone production / William E. Rainey, Windy B. Bollag, Carlos M. Isales -- Section VII: Endocrine disorders in renal failure -- Insulin resistance and diabetes in chronic renal disease / Donald C. Simonson -- Growth hormone / John D. Mahan -- Sexual dysfunction in men and women with chronic kidney disease / Biff F. Palmer -- Thyroid status in chronic renal failure patients: a non-thyroidal illness syndrome / Victoria S. Lim, Manish Suneja -- Metabolic acidosis of chronic kidney disease / Jeffrey A. Kraut, Glenn T. Nagami -- Pregnancy and the kidney / Chun Lam, S. Ananth Karumanchi.
  • Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. It takes an appreciation of the logistics of care in these difficult times of imbalance between more and sicker patients and fewer medical specialists. The impact of the right personnel, whose interest and training is in neurocritical care, has shown promise, both in terms of improving patient outcome and quality. The editors have updated this second edition with the latest knowledge and trends. Gathering together a group of international experts who champions the three characteristics Patient and Family Centered High Quality Care, Education, and Discovery needed in our NeuroICUs, the editors present to the reader a comprehensive textbook of neurocritical care, incorporating best practice / evidence-based medicine and performance improvement. This book is not an effort to embellish the shelf of a medical library; it is a practical bedside friend to be used to improve the neurological outcomes of those for whom we are honored to care: our patients.
  • Textbook of Neuromodulation encompasses the basic principles, methods and current clinical applications of invasive and non-invasive neuromodulation. Neurophysiological systems are reviewed along with the basic principles of neuroplasticity that constitutes the rationale for neuromodulation in human medicine. The overview of the neuromodulatory techniques is provided with special regard to safety and specific patient populations. Comprehensive and authored by leaders in the field, this resource presents the clinical potential, significance and practical applications of this innovative treatment approach.
  • Clinical History and Examination -- Physiology and pathology of the musculoskeletal system -- Epidemiology and genetics of rheumatic diseases -- Investigations -- Medical management of arthritis -- Musculoskeletal infection -- Role of the allied health professional -- Surgical management of joint disorders -- Fracture management -- Management of multiple trauma -- Children's fractures -- Regional injuries -- Sport and exercise associated problems in adults -- Generalized musculoskeletal problems -- Osteoarthritis and crystal arthropathies -- Inflammatory arthritis -- Systemic diseases -- Systemic complications of rheumatic diseases and rare arthropathies -- Bone disorders -- Tumours of the musculoskeletal system and pathological fractures -- Upper limb -- Cervical and lumbar spine -- Lower limb -- Normal variants in children -- Upper and lower limb disorders in children -- The paediatric spine and neuromuscular conditions -- Arthritis in children -- Sport and exercise associated problems in children and adolescents.
  • General principles -- Symptom assessment and management -- Psychosocial support -- Spiritual care -- Special patient populations -- End-of-life care across settings -- Pediatric palliative care -- Special issues for the nurse in end-of-life care -- Models of excellence and innovative community projects -- "A good death."
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  • Resuscitation-pediatric basic and advanced life support -- Neonatal resuscitation -- Shock -- Sedation and analgesia -- Emergency airway management-rapid sequence intubation -- Emergency medical services and transport medicine -- Emergency department recognition and management of victims of biological and chemical terrorism -- Abdominal distension -- Apnea -- Ataxia -- Breast lesion -- Coma and altered level of consciousness -- Constipation -- Cough -- Cyanosis -- Crying and colic in early infancy -- Dehydration -- Diarrhea -- Disturbed child -- Dizziness -- Edema -- Epistaxis -- Eye-red -- Eye-strabismus -- Eye-unequal pupils -- Eye-visual disturbances -- Fever -- Foreign body-ingestion/aspiration -- Gastrointestinal bleeding -- Groin masses -- Hearing loss --- Patients with heart murmurs -- Hematuria -- Hypertension -- Immobile arm -- Injury-ankle -- Injury-head -- Injury-knee -- Injury-shoulder -- Jaundice-unconjugated hyperbilirubinemia -- Jaundice-conjugated hyperbilirubinemia -- Limp -- Lymphadenopathy -- Neck mass -- Neck stiffness -- Odor-unusual -- Oligomenorrhea -- Oral lesions -- Pain-abdomen -- Pain-back -- Pain-chest -- Pain-dysphagia -- Pain-dysuria -- Pain-earache -- Headache -- Pain-joints -- Pain-scrotal -- Pallor -- Palpitations -- Polydipsia -- Rash-eczematous -- Rash-maculopapular -- Rash-papular lesions -- Rash-papulosquamous lesions -- Rash-petechiae and purpura -- Rash-urticaria -- Rash-vesicobullous -- Respiratory distress -- Seizures -- The septic-appearing infant -- Sore throat -- Stridor -- Syncope -- Tachycardia -- Urinary frequency in childhood -- Vaginal bleeding -- Vaginal discharge -- Vomiting -- Weakness -- Wheezing -- Weight loss -- Asthma and allergic emergencies -- Bite and stings -- Cardiac emergencies -- Dermatologic urgencies and emergencies -- Endocrine emergencies -- Environmental emergencies -- Injuries involving radiation -- Gastrointestinal emergencies -- Pediatric and adolescent gynecology -- Hematologic emergencies -- Infectious disease emergencies -- Infectious disease emergencies-sexually transmitted diseases -- Metabolic emergencies -- Problems in the early neonatal period -- Neurologic emergencies -- Oncologic emergencies -- Pulmonary emergencies -- Emergencies in cystic fibrosis -- Renal and electrolyte emergencies -- Rheumatologic emergencies -- Toxicologic emergencies -- Evaluation of the ill returning traveler -- An approach to the injured child -- Major trauma -- Minor trauma-lacerations -- Abdominal trauma -- Burns -- Dental trauma -- Otolaryngologic trauma -- Facial trauma -- Genitourinary trauma -- Hand trauma -- Musculoskeletal trauma -- Neck trauma -- Neurotrauma -- Eye trauma -- Thoracic trauma -- Minor lesions and injuries -- Approach to the care of the technology-assisted child -- Abdominal emergencies -- Dental emergencies -- Otolaryngologic emergencies -- Urologic emergencies -- Orthopedic emergencies -- Neurosurgical emergencies, nontraumatic -- Ophthalmic emergencies -- Thoracic emergencies -- Transplantation emergencies -- Adolescent emergencies -- Behavioral emergencies -- Child abuse -- Psychiatric emergencies -- Ultrasound -- Illustrated techniques of pediatric emergency procedures -- App. A: Pediatric emergency medicine equipment -- App. B: Emergency drug compendium -- App. C: Practical information -- App. D: Parental instruction sheets -- App. E: Clinical pathways in emergency medicine.
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  • Section 1. Basic concepts -- section 2. Chronic arthritis -- section 3. Systemic connective tissue diseases -- section 4. Systemic vasculitis -- section 5. Arthritis related to infection -- section 6. Systemic disorders with rheumatic manifestations -- section 7. Noninflammatory causes of musculoskeletal pain.
  • Basics of Personalized Medicine -- Molecular Diagnostics as Basis of Personalized Medicine -- Role of Biomarkers in Personalized Medicine -- Pharmacogenetics -- Pharmacogenomics -- Role of Pharmacoproteomics -- Role of Metabolomics in Personalized Medicine -- Personalized Biological Therapies -- Development of Personalized Medicine -- Personalized Therapy for Cancer -- Personalized Management of Neurological Disorders -- Personalized Therapy of Cardiovascular Diseases -- Personalized Management of Miscellaneous Disorders -- Personalized Preventive Medicine -- Organization of Personalized Medicine -- Ethical and Regulatory Aspects of Personalized Medicine -- Economics of Personalized Medicine -- Future of Personalized Medicine.
  • "Derive the maximum diagnostic information from interviewing and examining patients with Textbook of physical diagnosis. Employing a compassionate, humanistic approach, Dr. Swartz explores how cultural differences can influence communication, diet, family relationships, and health practices and beliefs, and demonstrates that your interpersonal awareness is just as essential in physical diagnosis as your level of technical skill. This medical reference book features numerous high-quality color images, an easy-to-use design, and detailed descriptions of exam techniques, making it an essential guide for physicians, nurse practitioners, and physician assistants"-- Publisher's description.
  • Textbook of psychopharmacology 2009
  • Theoretical models of psychodynamic psychotherapy -- Techniques of psychodynamic psychotherapy -- Techniques of brief psychodynamic psychotherapy -- Applications of psychodynamic psychotherapy to specific disorders : efficacy and indications -- Combining psychodynamic psychotherapy with medication -- Theory of cognitive therapy -- Techniques of cognitive-behavioral therapy -- Applications of individual cognitive-behavioral therapy to specific disorders : efficacy and indications -- Combining cognitive-behavioral therapy with medication -- Theory of interpersonal psychotherapy -- Techniques of individual interpersonal psychotherapy -- Applications of individual interpersonal psychotherapy to specific disorders : efficacy and indications -- Combining interpersonal psychotherapy with medication -- Theory of supportive psychotherapy -- Techniques of individual supportive psychotherapy -- Applications of individual supportive psychotherapy to psychiatric disorders : efficacy and indications -- Combining supportive psychotherapy with medication -- Family systems theory and practice -- Couples therapy -- Emotionally focused couples therapy : an attachment-based treatment -- Psychodynamic couples therapy : an object relations approach -- Behavioral couples therapy -- Psychodynamic group therapy -- Family intervention for psychotic and severe mood disorders -- Group cognitive-behavioral therapy for chronic pain -- Theory and practice of psychotherapy integration -- Theory and practice of dialectical behavioral therapy -- Theory and practice of mentalization-based therapy -- Brain processes informing psychotherapy -- Professional boundaries in psychotherapy.
  • Rapid response systems history and terminology -- RR's general principles -- Measuring and improving safety -- Integrating a rapid response system into a patient safety program -- Acute hospitalist medicine and the rapid response system -- Medical trainees and patient safety -- Rapid response systems: a review of the evidence -- Healthcare systems and their (lack of) integration -- Creating process and policy change in healthcare -- The challenge of predicting in-hospital cardiac arrests and deaths -- The meaning of vital signs -- Matching illness severity with level of care -- Causes of failure to rescue -- Impact of hospital size and location on feasibility of RRS -- Barriers to the implementation of RRS -- An overview of the afferent limb -- The impact of delayed RRS activation -- The case for family activation of the RRS -- RRT: nurse-led RRSs -- MET: physician-led RRSs -- Pediatric RRSs -- Sepsis response team -- Other efferent limb teams: (BAT, DAT, M, H, and trauma) -- Other efferent limb teams: crisis response for obstetric patients -- Personnel resources for responding teams -- Equipment, medications, and supplies for an RRS -- The administrative limb -- The second victim -- RRSs in teaching hospitals -- The nurse's view of RRS -- Resident training and RRSs -- Optimizing RRSs through simulation -- Evaluating effectiveness of complex system interventions -- RRS education for ward staff -- Standardized process and outcome assessment tool -- The impact of RRSs on choosing "not-for-resuscitation" status -- The costs and savings.
  • The evolution of three-dimensional echocardiography: how did it happen -- Technical principles of transthoracic three-dimensional echocardiography -- 3D transesophageal echocardiographic technologies -- Three-dimensional echocardiography in clinical practice -- Advanced evaluation of LV functions with 3D echocardiography -- Three-dimensional echocardiographic evaluation of the mitral valve -- Three-dimensional echocardiographic evaluation of LV dyssynchrony and stress testing -- Three-dimensional echocardiography of aortic valve -- Three-dimensional echocardiographic evaluation of the right ventricle -- Three-dimensional echocardiography in congenital heart disease -- Three-dimensional echocardiography to assess intra-cardiac masses -- Real time three dimensional transesophageal echocardiography for guidance of catheter based interventions -- Future developments of three-dimensional echocardiography -- Real time three-dimensional transesophageal echocardiography -- The role of echocardiography in the surgical management of degenerative mitral valve disease -- Visualization and assessment of coronary arteries with three-dimensional echocardiography -- Assessment of tricuspid valve morphology and function -- Role of three-dimensional echocardiography in drug trials.
  • Evolution of Cataract Surgery -- Current Outcomes with Cataract Surgery: Can We Do Better? -- Femtosecond Laser Fundamentals -- Challenges of Femtosecond Laser Technologies for Cataract Surgery -- Imaging Systems and Image-Guided Surgery -- The Patient Interface: Setting the Stage for Treatment -- Laser Capsulotomy -- Nucleus Fragmentation and Disassembly in ReLACS -- Primary Transcorneal Laser Incisions -- Relaxing Incisions for Astigmatism Correction in ReLACS -- Femtosecond Laser Versus Phacoemulsification -- Economics of ReLACS: Marketing a New Technology to Your Patients -- Step-By-Step: Starting Your ReLACS Practice -- Global Implications of Refractive Laser Assisted Cataract Surgery (ReLACS) -- Commercially Available Systems: Alcon/LenSx -- Commercially Available Systems: LensAR Laser System -- Commercially Available Systems: OptiMedica's Catalys Precision Laser System -- Commercially Available Systems: The TECHNOLAS Femto-Cataract Approach -- The Future of ReLACS and Femtosecond Laser Ocular Surgery.
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    Peritonitis and intra-abdominal abscess / J.J. Tjandra -- Ascites / D.M.A. Francis & D.A.K. Watters -- Neck swellings / C.J. O'Brien -- Dysphagia / R.J.S. Thomas -- Leg ulcers / J. Harris -- Leg swelling / S.T.F. Chan & D.M.A. Francis -- Haematuria / D. Lenz -- Post-operative complications / P. Devitt -- Claw hand / W. Morrison -- Massive haemoptysis / J.A. Smith -- Epistaxis / N. Vallance -- Leg pain / B. Kavar -- Acute scrotal pain / A.J. Costello -- Acute back pain / J.V. Rosenfeld -- Post-traumatic confusion / J.D. Laidlaw -- Double vision / J.E.K. Galbraith. Pre-operative management / I.G. Martin -- Anaesthesia and pain management / D. Williams -- Post-operative management / P. Devitt -- Surgical techniques / D.M.A. Francis -- Nutrition and the surgical patient / B.K. Parry & A.G. Hill -- Care of the critically ill patient / J.J. Presneill & J.F. Cade -- Surgical infections / J.C. Hall -- Transplantation surgery / D.M.A. Francis -- Principles of surgical oncology / R.J.S. Thomas -- Gastro-oesophageal reflux / G.G. Jamieson -- Tumours of the oesophagus / S. Law & J. Wong -- Peptic ulcer disease / S.C.S. Chung -- Gastric neoplasms / I.G. Martin -- Gallstones / D. Fletcher -- Benign and malignant diseases of the hepatobiliary system / N. Collier & D. Morris -- Liver infections / C. Christophi & V. Muralidharan -- Diseases of the Pancreas / J. Toouli -- Portal hypertension / C. Christophi & V. Muralidharan -- Small bowel obstruction / J.J. Tjandra -- Large bowel obstruction / A.L. Polglase -- Mesenteric vascular disease / J.J. Tjandra -- Principles of plastic surgery / W. Morrison -- Principles of trauma management / S.K. D'Amours & S.A. Deane -- Burns / R.T. Judson -- Fractures and dislocations / P. Choong -- Diseases of bone and joints / P. Choong -- Head injuries / A.H. Kaye -- Intracranial tumours, infection and aneurysms / A.H. Kaye -- Nerve injuries, peripheral nerve entrapments and spinal cord compression / A.H. Kaye -- Disorders of the arterial system / J. Harris -- Extracranial vascular disease / J. Harris -- Venous and lymphatic diseases of the limbs / M. Grigg & C. Miles -- Genitourinary tract / R. Gardiner -- External genitalia in the male / A. Costello -- Principles and practice of cardiac surgery / J. Tatoulis & J.A. Smith -- Common topics in thoracic surgery / J.A. Smith -- Chronic constipation / Y.H. Ho -- Faecal incontinence / J.J. Tjandra -- Rectal bleeding / J.J. Tjandra -- Haematemesis and melaena / R.J.S. Thomas -- Obstructive jaundice / D. Fletcher -- The acute abdomen / M. Levitt -- The appendix and Meckel's diverticulum / J.J. Tjandra -- Tumours of the small bowel / J.J. Tjandra -- Colorectal cancer and adenoma / J.J. Tjandra -- Diverticular disease of the colon / J.J. Tjandra -- Inflammatory bowel disease / J.J. Tjandra -- Radiation injuries to the small and large bowel / M.J. Soloman & J.J. Tjandra -- Enterocutaneous fistula / J.J. Tjandra -- Rectal prolapse / J.J. Tjandra -- Intestinal stomas / J.J. Tjandra -- Anal and perianal disorders / L. Bokey, P. Chapuis & J.J. Tjandra -- Breast surgery / J.J. Tjandra & J.P. Collins -- Thyroid / L. Delbridge -- Parathyroid / L. Delbridge & G. Clunie -- Tumours of the adrenal gland / L. Delbridge -- Endocrine tumours of the pancreas / G.J.A. Clunie -- Eye injuries and infections / J.E.K. Galbraith -- Otorhinolaryngology / S. O'Leary & V. Vallance -- Tumours of the head and neck / R.T. Judson -- Hernias / D.M.A. Francis -- Tumours and cysts of the skin / G.J.A. Clunie & P. Devitt -- Soft tissue tumours / J.W. Serpell -- Infections of the extremities / D.M.A. Francis --
  • Cervical spine anatomy -- Approaches to the upper cervical spine -- Anterior surgical approach to the cervical spine -- Posterior surgical approach to the cervical spine -- Anterior approaches and surgical considerations for pathology of the cervicothoracic junction -- Developmental and congenital disorders of the cervical spine -- Biomechanics of the cervical spine -- Evaluation of the cervical spine -- Radiographic and computed tomography evaluation of the cervical spine -- Magnetic resonance imaging of the cervical spine -- Neurophysiologic monitoring of the cervical spine -- Cervical degenerative disk disease -- Cervical radiculopathy -- Cervical spondylotic myelopathy -- Cervical deformity and treatment algorithms -- Ossification of the posterior longitudinal ligament -- Occipitocervical and upper cervical spine fractures -- Subaxial cervical spine injuries -- Spinal cord injuries and syndromes -- Traumatic arterial injuries : diagnosis and management -- Stingers and transient paresis -- Primary tumors of the spinal cord -- Primary bony tumors of the cervical spine -- Metastatic disease of the cervical spine -- Infections of the cervical spine -- Tuberculosis of the cervical spine -- Rheumatoid arthritis of the cervical spine -- Ankylosing spondylitis of the cervical spine -- Syringomyelia -- Anterior cervical diskectomy and fusion -- Anterior cervical corpectomy and fusion and hybrid techniques -- Cervical disk arthroplasty -- Anterior cervical foraminotomy -- Laminectomy and fusion -- Cervical laminoplasty -- Posterior cervical endoscopic laminoforaminotomy -- Osteotomies of the cervical spine -- Occipitocervical fixation -- C1 lateral mass and C2 pedicle screw fixation -- C1-C2 transarticular screws -- C2 translaminar screw fixation -- Cervical pedicle screws -- Lateral mass screws -- Interspinous wiring -- Minimally invasive techniques in the cervical spine -- Image-guided navigation for cervical spine surgery -- Biologics for intervertebral disk regeneration and repair -- Biologics for spinal fusion -- Intervertebral disk transplantation -- Vascular injuries -- Spinal cord and nerve injuries in the cervical spine -- Tracheoesophageal injuries -- Dural tear -- Wound complications -- Adjacent segment disease -- Nonunions and implant failures of the cervical spine.
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  • As soldiers and combat veterans have returned from the wars in Iraq and Afghanistan traumatic brain injury (TBI) has been identified as the "signature injury" of those wars. TBI is also in the news on a daily basis due to sports injuries. This new edition has been revised and updated from the 2005 first edition to reflect the exponential expansion of research and clinical data amassed in the intervening years. Each chapter was written and reviewed by the foremost authorities in neuropsychiatry, neurology, rehabilitation medicine, and the other specialties who assess, diagnose, and treat these patients. The revisions and additions to this comprehensive volume were made to ensure that the scope and coverage is both up-to-date and down-to-earth. Key features include: New chapters on epidemiology, neuropathology, and genetics of TBI; new chapter on TBI in the military emphasizing the unique feature of blast injury; A new chapter on posttraumatic stress disorder (PTSD), which emphasizes the common co-occurrence of TBI and PTSD in both combat and other settings; Enhanced coverage of psychopharmacology and psychotherapy for the psychiatric symptoms associated with TBI; Information on the social ramifications of TBI so that clinicians will better understand and help their patients cope with the complex legal, financial, and insurance-based struggles their patients who have sustained TBI encounter; Each chapter concludes with essential points and key references to focus attention and consolidate learning; A foreword written by Bob Woodruff (the ABC World News correspondent who sustained a TBI while covering the war in Iraq) and his wife, Lee Woodruff, who underscore that although this volume is intended to be read primarily by professionals, patients and families may also find the information in the textbook to be of keen interest and practical application.
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    Uncommon tumors of the kidney -- Uncommon cancers of the bladder -- Urethral cancer -- Uncommon cancers of the prostate -- Rare tumors of the testis and paratesticular tissues -- Uncommon tumors of the oral cavity and adjacent structures -- Rare tumors of the larynx -- Nasopharyngeal carcinoma in non-endemic populations -- Esthesioneuroblastoma -- Neoplastic disorders of the adrenal glands -- Uncommon cancers of the thyroid -- Parathyroid carcinoma -- Metaplastic breast carcinoma -- Adenoid cystic carcinoma of the breast -- Non-Hodgkin lymphoma of the breast -- Male breast cancer -- Phyllodes tumor of the breast -- Carcinosarcoma of the breast -- Tubular carcinoma -- Thymoma and thymic carcinoma -- Primary lymphomas of the lung -- Primary sarcomas of the lung -- Mesotheliomas -- Primary melanoma of the lung -- Large cell neuroendocrine -- Carcinoid tumors of the lung -- Bronchioloalveolar carcinoma of the lung -- Primary adenoid cystic carcinoma of the lung -- Mucoepidermoid tumors of the lung -- Uncommon cancers of the esophagus -- Uncommon cancers of the stomach -- Unusual pancreatic tumors -- Uncommon hepatobiliary tumors -- Cancer of the small bowel -- Unusual tumors of the colon, rectum and anus -- Cancer of the appendix -- Gastrointestinal stromal tumors -- Small cell carcinomas of the gastrointestinal tract -- Extra-ovarian primary peritoneal carcinomas -- Borderline tumors and other rare epithelial tumors of the ovary -- Stromal tumors of the ovary -- Germ cell tumors of the ovary -- Fallopian tube cancer -- Uterine sarcomas and unusual endometrial carcinomas -- Tumors of the cervix -- Tumors of the vulva and vagina -- Gestational trophoblastic diseases -- Rare leukemias -- Rare lymphomas -- Uncommon presentations of plasma cell dyscrasias -- Unusual cutaneous malignancies -- Dermatofibrosarcoma protuberans -- Merkel cell carcinoma -- Melanotic lesions of the meninges -- Langerhans' cell histiocytosis of the central nervous system -- Chordomas -- Meningeal sarcomas -- Atypical and malignant meningiomas -- Primary intracranial germ cell tumors -- Primary central nervous system lymphoma -- Choroid plexus papilloma and carcinoma -- Glioma and other neuroepithelial neoplasms -- Medulloblastoma and CNS primitive neuroectodermal tumors -- Craniopharyngiomas -- Ophthalmic cancers -- Rare pediatric malignancies of the head and neck -- Uncommon pediatric tumors of the thorax -- Uncommon tumors of the gastrointestinal tract in children -- Uncommon pediatric genitourinary tumors -- Uncommon endocrine tumors in children and adolescents -- Uncommon pediatric brain tumors -- Malignant tumors of the skin and subcutaneous tissue in children.
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    Anatomy and embryology -- Congenital anomalies -- Diagnostic techniques -- Functional renal anatomy, renal physiology, and contrast management -- The retroperitoneum -- The adrenal gland -- Renal cystic disease -- Renal tumors -- Renal inflammatory disease -- Vascular diseases -- Renal hypertension -- Renal failure and medical renal disease -- Renal transplantation -- Nephrocalcinosis and nephrolithiasis -- Pelvicalyceal system and ureter -- The urinary bladder -- Prostate and seminal vesicles -- Urethra and penis -- Scrotum and contents -- Urinary tract trauma -- Female genital tract.
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  • Methods of data representation, interpretation, and analysis / Craig K. Svensson and Tapash K. Ghosh -- Thermodynamics and states of matter / Adam M. Persky, Laszlo Prokai, and Jeffrey A. Hughes -- Solubility / Jeffrey A. Hughes .. [et al.] -- Physiochemical factors affecting biological activity / Hemant Alur ... [et al.] -- Micromeritics and rheology / Sunil S. Jambhekar -- Principles and applications of surface phenomena / Laszlo Prokai ... [et al.] -- Theory and applications of diffusion and dissolution / Xiaoling Li and Bhaskara Jasti -- Chemical kinetics and stability / Tapash K. Ghosh -- Drug and dosage form development: regulatory perspectives / Edward Dennis Bashaw -- Oral conventional solid dosage forms: powders and granules, tablets, lozenges, and capsules / Melgardt M. de Villiers -- Oral controlled release solid dosage forms / Emmanuel O. Akala -- Oral liquid dosage forms: solutions, elixirs, syrups, suspensions, and emulsions / William M. Kolling and Tapash K. Ghosh -- Parenteral routes of delivery / Yon Rojanasakul and Carl J. Malanga -- Transdermal and topical drug delivery systems / Bhaskara R. Jasti, William Abraham, and Tapash K. Ghosh -- Rectal and vaginal routes of drug delivery / Nikhil R. Shitut .. [et al.] -- Ocular, nasal, pulmonary, and otic routes of drug delivery / Harisha Atluri ... [et al.] -- Delivery of peptide and protein drugs / Emily Ha ... [et al.].
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  • Section I. A theory of evaluating drugs -- section II. A theory of evidence in drug development -- section III. Additional topics.
  • Highlights and trends in cell encapsulation / Gorka Orive and José Luis Pedraz -- Biomaterials in cell microencapsulation / Edorta Santos ... [et al.] -- Development of subsieve size capsules and application to cell therapy / Shinji Sakai and Koei Kawakami -- Regulatory considerations in application of encapsulated cell therapies / J. van Zanten and Paul de Vos -- Treatment of diabetes with encapsulated islets / Paul de Vos, Milica Spasojevic, and Marijke M. Faas -- Epo delivery by genetically engineered C2C12 myoblasts immobilized in microcapsules / Ainhoa Murua ... [et al.] -- Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering, and cell therapy / Zun Chang Liu and Thomas Ming Swi Chang -- Microencapsulated choroid plexus epithelial cell transplants for repair of the brain / Christopher G. Thanos, Briannan Bintz, and Dwaine F. Emerich -- Therapeutic application of cell microencapsulation in cancer / Brian Salmons and Walter H. Gunzburg -- Inorganic nanoporous membranes for immunoisolated cell-based drug delivery / Adam Mendelsohn and Tejal Desai -- Cell microencapsulation / Grace J. Lim ... [et al.] -- Commercial applicability of cell microancapsulation : a review of intellectual property rights / Stephan M. Meier.
  • "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. 4 of cover.
  • 2012 ClinicalKey
    Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presentsssnew and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathol.
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    A collection of papers by James R. Allen and Barbara A. Allen.
  • Setting up a Kinase Discovery and Development Project / Gideon Bollag -- Drug Efficacy Testing in Mice / William Y. Kim, Norman E. Sharpless -- Gastrointestinal Stromal Tumors / Cristina Antonescu -- EGFR Mutant Lung Cancer / Yixuan Gong, William Pao -- Targeting Oncogenic BRAF in Human Cancer / Christine A. Pratilas, Feng Xing, David B. Solit -- Beyond BRAF in Melanoma / Adil Daud, Boris C. Bastian -- JAK-Mutant Myeloproliferative Neoplasms / Ross L. Levine -- Will Kinase Inhibitors Make it as Glioblastoma Drugs? / Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel -- Predictive Genomic Biomarkers / Rakesh Kumar, Rafael G. Amado -- Epigenetic Biomarkers / Timothy A. Chan, Stephen B. Baylin -- Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer / Robert L. Cohen.
  • The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. The selective irradiation of tumor cells through molecular biological mechanisms is now permitting the radiopharmaceutical control of tumors that are unresectable and unresponsive to either chemotherapy or conventional radiotherapy. In this up-to-date, comprehensive book, world-renowned experts discuss the basic principles of radionuclide therapy, explore in detail the available treatments, explain the regulatory requirements, and examine likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the important role of the therapeutic nuclear physician in delivering the effective coordination of a diverse multidisciplinary team that is essential to the safe provision of treatment.
  • Biopharmaceutical proteins: opportunities and challenges / John R. Birch and Yemi Onakunle -- Expression of antibody fragments by periplasmic secretion in Escherichia coli / Andrew G. Popplewell ... [et al.] -- Secretory production of therapeutic proteins in Escherichia coli / Sang Yup Lee, Jong Hyun Choi, and Sang Jun Lee -- Expression of recombinant LTB protein in marine vibrio VSP60 / Wang Yili and Si Lusheng -- Heterologous gene expression in yeast / Lee J. Byrne, Kenneth J. O'Callaghan, and Mick F. Tuite -- Pharmaceutical proteins from methylotrophic yeasts / Eric C. de Bruin ... [et al.] -- Expression of human papillomavirus type 16 L1 in baculovirus expression systems: a case study / Zheng Jin, Si Lusheng, and Wang Yili -- Large-scale transient expression of therapeutic proteins in mammalian cells / Sabine Geisse, Martin Jordan, and Florian M. Wurm -- Site-specific integration for high-level protein production in mammalian cells / Bhaskar Thyagarajan and Michele P. Calos -- Production of recombinant therapeutic proteins by mammalian cells in suspension culture / Lily Chu, Ilse Blumentals, and Gargi Maheshwari -- Transgene control engineering in mammalian cells / Beat P. Kramer and Martin Fussenegger -- Fusion to albumin as a means to slow the clearance of small therapeutic proteins using the Pichia pastoris espression system: a case study / William P. Sheffield, Teresa R. McCurdy, and Varsha Bhakta -- High throughput recovery of therapeutic proteins from the inclusion bodies of Escherichia coli: an overview / Amulya K. Panda -- Isolation, solubilization, refolding, and chromatographic purification of recombinant human growth hormone from inclusion bodies of Escherichia coli cells: a case study / Surinder M. Singh ... [et al.] -- Large-scale preparation of factor VIIa from human plasma: a case study / Teruhisa Nakashima and Kazuhiko Tomokiyo -- Purification of clinical-grade monoclonal antibodies by chromatographic methods / Alberto L. Horenstein, Ilaria Durelli, and Fabio Malavasi -- Virus elimination and validation / Nicola Boschetti and Anna Johnston -- Virus removal by nanofiltration / Marina Korneyeva and Scott Rosenthal -- Determining residual host cell antigen levels in purified recombinant proteins by slot blot and scanning laser densitometry / Aaron P. Miles, Daming Zhu, and Allan Saul -- Principles of biopharmaceutical protein formulation: an overview / Scott P. Sellers and Yuh-Fun Maa -- Solid-state protein formulation: methodologies, stability, and excipient effects / Yuh-Fun Maa and Scott P. Sellers -- Stabilization of therapeutic proteins by chemical and physical methods / Ken-ichi Izutsu -- Extraction and characterization of vaccine antigens from water-in-oil adjuvant formulations / Aaron P. Miles and Allan Saul -- Probing reversible self-association of therapeutic proteins by sedimentation velocity in the analytical ultracentrifuge / Bernardo Perez-Ramirez and John J. Steckert -- Biological characterization of pegylated interferons: a case study / Lei Xie ... [et al.] -- Characterization of interferon [alpha]-2B pegylated via carboxyalkylation: a case study / David C. Wylie ... [et al.] -- Quantifying recombinant proteins and their degradation products using SDS-PAGE and scanning laser densitometry / Aaron P. Miles and Allan Saul -- Extraction and denaturing gel electrophoretic methodology for the analysis of yeast proteins / Kenneth J. O'Callaghan, Lee J. Byrne, and Mick F. Tuite -- Characterization of therapeutic proteins by membrane and in-gel tryptic digestion / C. Mark Smales, Rosalyn J. Marchant, and Michèle F. Underhill -- Oligosaccharide release and MALDI-TOF MS analysis of N-linked carbohydrate structures from glycoproteins / Rodney G. Keck, John B. Briggs, and Andrew J.S. Jones -- Capillary electrophoresis of carbohydrates derivatized with fluorophoric compounds / Stacey Ma ... [et al.] -- High-throughput LC/MS methodology for [alpha](1->3)Gal determination of recombinant monoclonal antibodies: a case study / Lihua Huang and Charles E. Mitchell -- Carbohydrate structural characterization of Fas ligand inhibitory protein / Lihua Huang ... [et al.] -- Top-down characterization of protein pharmaceuticals by liquid chromatography/mass spectrometry: application to recombinant factor IX comparability-a case study / Jason C. Rouse ... [et al.] -- Sample preparation procedures for high-resolution nuclear magnetic resonance studies of aqueous and stabilized solutions of therapeutic peptides / Mark J. Howard.
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    "Therapeutic Revolutions examines the evolving relationship between American medicine, psychiatry, and culture from World War II to the dawn of the 1970s. In this richly layered intellectual history, Martin Halliwell ranges from national politics, public reports, and healthcare debates to the ways in which film, literature, and the mass media provided cultural channels for shaping and challenging preconceptions about health and illness. Beginning with a discussion of the profound impact of World War II and the Cold War on mental health, Halliwell moves from the influence of work, family, and growing up in the Eisenhower years to the critique of institutional practice and the search for alternative therapeutic communities during the 1960s. Blending a discussion of such influential postwar thinkers as Erich Fromm, William Menninger, Erving Goffman, Erik Erikson, and Herbert Marcuse with perceptive readings of a range of cultural text that illuminate mental health issues--among them Spellbound, Shock Corridor, Revolutionary Road, and I Never Promised You a Rose Garden--this compelling study argues that the postwar therapeutic revolutions closely interlink contrasting discourses of authority and liberation." -- Publisher's website.
  • Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination.
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  • Introduction to therapeutic and functional stretching -- Functional and dysfunctional ROM -- Causes of ROM loss and therapeutic potential of rehabilitation -- Adaptation in ROM loss and recovery -- Specificity in ROM rehabilitation -- The overloading condition for recovery -- Exposure and scheduling the ROM challenge -- Rehabilitating the active ROM : neuromuscular rehabilitation -- Pain management and ROM-desensitization -- Stretch tolerance model -- Psychological and behavioral considerations in ROM rehabilitation -- Towards a functional approach -- Demonstration of functional approach in ROM rehabilitation
  • Overview of TNF superfamily : a chest full of potential therapeutic targets / Iqbal S. Grewal -- Therapeutic interventions targeting CD40l (CD154) and CD40 : the opportunities and challenges / Che-Leung Law and Iqbal S. Grewal -- Targeting TNF for treatment of cancer and autoimmunity / Gautam Sethi ... [et al.] -- Targeting of BAFF and APRIL for autoimmunity and oncology / Maureen C. Ryan and Iqbal S. Grewal -- The role of FASL and FAS in health and disease / Martin Ehrenschwender and Harald Wajant -- OX40 (CD134) and OX401 / Michael J. Gough and Andrew D. Weinberg -- Targeting CD70 for human therapeutic use / Tamar Boursalian ... [et al.] -- 4-1BB as a therapeutic target for human disease / Seung-Woo Lee and Michael Croft -- Rank(l) as a key target for controlling bone loss / Andreas Leibbrandt and Josef M. Penninger -- Targeting the light-HVEM pathway / Carl F. Ware -- GITR : a modulator of immune response and inflammation / Giuseppe Nocentini and Carlo Riccardi -- Targeting CD30/CD30l in oncology and autoimmune and inflammatory diseases / Ezogelin Oflazoglu, Iqbal S. Grewal, and Hans Peter Gerber -- Tumor necrosis factor receptor superfamily member 21 : TNFR-related death receptor-6, DR6 / Robert Benschop, Tao Wei, and Songqing Na -- TRAIL and other TRAIL receptor agonists as novel cancer therapeutics / Christina Falschlehner ... [et al.] -- Therapeutic potential of VEGI/TL1A -- In autoimmunity and cancer / Gautam Sethi, Bokyung Sung, and Bharat B. Aggarwal.
  • This book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
  • This book elaborates on a whole new understanding of digestive endoscopy, the core of which is to treat quite a number of diseases using minimally invasive methods, provides the walls of the digestive tube are free of perforations. Currently, the tunnel technique has been applied in the treatment of digestive early stage carcinomas, esophageal achalasia and submucosal tumors originating from muscularis propria. And this promising technique would surely be more widely used in the future. The main contents of this book include the history of the digestive endoscopic tunnel technique, the practical anatomy involved, operation steps, indications and contraindications, complications and possible future exploration fields. This book is well suited for doctors and surgeons performing digestive endoscopic therapies.
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    "For therapists caught between their grief and the empathy they provide for their clients, this collection explores the complexity of bereavement within the practice setting. It also examines the professional and personal ramifications of death and loss for the practicing clinician. Featuring original essays from longstanding practitioners, the collection demonstrates the universal experience of bereavement while outlining a theoretical framework for the position of the bereft therapist. Essays cover the unexpected death of clients and patient suicide, personal loss in a therapist's life, the grief of clients who lose a therapist, disastrous loss within a community, and the grief resulting from professional losses and disruptions." -- [Publisher-supplied data]
  • Cancer Overview -- Introduction to Therapy Dogs -- Dogs as Cancer Detectors -- Dog Therapy with Cancer Treatment -- Adding Therapy Dogs to Your Cancer Treatment Team -- Incorporating Companion Dogs into Cancer Rehab: Emotional Support -- Incorporating Companion Dogs into Cancer Rehab: Benefits from Physical Exercise for Cancer Patients -- Incorporating Companion Dogs into Cancer Rehab: Dog-Themed Exercise Program for Cancer Patients -- Incorporating Companion Dogs into Cancer Rehab: Practical Tips for Adding a Dog into the Home During Cancer Treatment and Recovery -- Resources.
  • Therapy in sleep medicine 2012
    2012 ClinicalKey
    Introduction to sleep medicine -- Background to sleep medicine therapeutics -- Pharmacology principles -- Insomnias -- Sleep-related breathing disorders -- Central hypersomnolence -- Movement disorders affecting sleep -- Circadian rhythm disorders -- Therapy in pediatric sleep-related disorders -- Parasomnias in adults -- Sleep-related medical disorders -- Neurologic disorders and sleep -- Therapy of sleep disturbances associated with psychiatric disorders -- Special situations and the future -- Appendix: Effects of drugs on sleep.
  • Presenting over 100 rehabilitation protocols for the hand and upper extremity in an easy-to-use, step-by-step format, this practical reference provides surgeons and therapists alike with a go-to source for the therapy technique or strategy appropriate for their patients. Covering injuries from the shoulder, elbow, wrist, hand and fingers, each protocol includes bullet-pointed steps in daily or weekly increments following the injury or surgery and are inherently adaptable to the specific surgical intervention or rehabilitation requirement. Procedures following arthroplasty, extensor and flexor tendon injuries, fractures and dislocations, ligament and soft tissue injures, and nerve compression syndromes are among the many and multifaceted therapies presented. This book will be an invaluable resource for the orthopedic surgeon, hand surgeon, physical therapist, occupational therapist, hand therapist and any active clinician treating injuries to the hand and upper extremity.
  • Cultured cells for therapy are now being prepared by industries in the US, Japan and Korea and are used in the aforesaid countries as well as France, Sweden and Greece, for the treatment of disease. This title describes the discoveries in the author's laboratory that led to therapy with cultured cells.
  • History and current definition of treatment resistant schizophrenia / Helio Elkis -- Assessment of therapy resistant schizophrenia / Jean Pierre Lindenmayer -- Neuropsychology of treatment resistant schizophrenia / Neil D. Woodward & Herbert Y. Meltzer -- Genetic studies in treatment resistant schizophrenia / Vincenzo De Luca ... [et al.] -- Neuroimaging of treatment resistant schizophrenia / Joao Guilherme Borgio ... [et al.] -- Duration of untreated psychosis and premorbid functioning : relationship with treatment response and therapy-resistant schizophrenia / William Bobo & Herbert Meltzer -- Disease management: multidimensional approaches to incomplete recovery in psychosis / Tim J. Lambert -- The role of clozapine in the treatment of treatment-resistant schizophrenia / Herbert Meltzer -- Augmenting clozapine response in treatment resistant schizophrenia / Gary Remington -- New therapeutic strategies for resistance to clozapine and treatment resistance schizophrenia / Juliano Santos Souza ... [et al.] -- Eletroconvulsive therapy for treatment- refractory schizophrenia / Worrawat Chanpattana -- Treatment of therapy-resistant auditory verbal hallucinations in schizophrenia patients by repetitive transcranial magnetic stimulation (rTMS) / Martin Jandl & Wolfgang P. Kaschka.
  • Introduction / Frank T. Robb ... [et al.] -- Compatible solutes of (hyper)thermophiles and their role in protein stabilization / Helena Santos ... [et al.] -- Relationships among catalytic activity, structural flexibility, and conformational stability as deduced from the analysis of mesophilic-thermophilic enzyme pairs and protein engineering studies / Reinhard Sterner and Eike Brunner -- Membranes and transport proteins of thermophilic microorganisms / Sonja Verena Albers and Arnold J.M. Driessen -- Thermophilic protein-folding systems / Frank T. Robb and Pongpan Laksanalamai -- Physical properties of membranes composed of tetraether archaeal lipids / Parkson Lee-Gau Chong -- Glycolysis in hyperthermophiles / Peter Schonheit -- Industrial relevance of thermophiles and their enzymes / Garabed Antranikian -- Denitrification pathway enzymes of thermophiles / Simon de Vries and Imke Schroder -- DNA stability and repair / Malcolm F. White and Dennis W. Grogan -- Plasmids and cloning vectors for thermophilic archaea / Kenneth M. Stedman -- Genetic analysis in extremely thermophilic bacteria : an overview / Dennis W. Grogan -- Targeted gene disruption as a tool for establishing gene function in hyperthermophilic archaea / Haruyuki Atomi and Tadayuki Imanaka -- Nanobiotechnological potential of viruses of hyperthermophilic archaea / Tamara Basta and David Prangishvili -- Master keys to DNA replication, repair, and recombination from the structural biology of enzymes from thermophiles / Li Fan ... [et al.] -- DNA replication in thermophiles / Jae-Ho Shin, Lori M. Kelman, and Zvi Kelman -- DNA-binding proteins and DNA topology / Kathleen Sandman -- Structure and evolution of the Thermus thermophilus ribosome / Steven T. Gregory and Albert E. Dalberg -- Protein phosphorylation at 80C and above / Peter J. Kennelly -- Archaeal 20S proteasome: a simple and thermostable model system for the core particle / Joshua K. Michel and Robert M. Kelly.
  • Print Material
    v. 1. Biology, physiology, physics -- v. 2 Clinical applications.
  • The evolutionary basis of thermoregulation and exercise performance / F.E. Marino -- Comparative thermoregulation and the quest for athletic supremacy / F.E. Marino -- Thermoregulation, fatigue, and exercise modality / R. Tucker -- Neuromuscular response to exercise heat stress / S.S. Cheung -- Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms : the "canary in the coal mine" during exercise-heat stress? / G.P. Lambert -- Effects of peripheral cooling on characteristics of local muscle / E. Drinkwater -- Cooling interventions for the protection and recovery of exercise performance from exercise-induced heat stress / R. Duffield -- Ethnicity and temperature regulation / M.I. Lambert, T. Mann, J.P. Dugas -- Exercise heat stress and metabolism / T. Mündel.
  • "Thermostable Proteins: Structural Stability and Design provides a comprehensive, updated account of the physical basis of enhanced stability of thermophilic proteins and the design of tailor-made thermostable proteins, paving the way for their possible industrial applications. This book is devoted to understanding the survival mechanisms of "thermophilic life forms" at the molecular level with an emphasis on design strategies.The review chapters presented in Thermostable Proteins span a wide range of protein thermostability research. Basic structural, thermodynamic, and kinetic principles are explained and molecular strategies for the adaptation to high temperatures are delineated. In addition, this book covers: computing and simulation methods in current and future thermostability research, especially in nonempirical situations, how rigidity theory is used to improve the thermal adaptation of mesophiles Subtilisin-like serine proteases and their significant engineering applications. The state of knowledge concerning structure function relations and the origins of their structural stability. Computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or three-dimensional structures. Understanding the molecular basis of how thermostable and hyperthermostable proteins gain and maintain their stability and biological function at high temperatures remains an important scientific challenge. A more detailed knowledge of protein stability not only deepens our understanding of protein structure but also helps in obtaining insights into processes that drive protein activities folding, unfolding, and misfolding essential to biological function"--Provided by publisher.
  • Early chemistry -- Early thiamine deficiency -- Thiamine deficiency in mammals -- Beriberi -- Wernicke's disease -- Central pontine myelinolysis, alcoholic cerebellar degeneration, and Marchiafava-Bignami disease -- Leigh's disease -- African seasonal ataxia -- Inherited ataxias -- Thiamine deficiency in serious illness -- World health concerns -- Future prospects -- Bontius translation -- Thiamine synonyms -- Nobel Prize acceptance speech of Dr. Christian Eijkman, 1929.
  • An online library of Thieme books. Includes Thieme eRadiology and RadCases content made available through the Medlantis database.
  • An online journal and ebook service of the Thieme Publishing Group. The ebook package is also called Thieme Clinical Collections.
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    Dead Germans and other philosophers: ethics as a professional or public occupation -- Something old: a brief review -- Something newer: supply-side ethics -- Lifeboat ethics: scarcity as an unnatural state -- Biopolitics, biophilosophies, and bioethics -- Principles of biomedical ethics -- Bioethics and conformal humans -- Research and genetics: "for the benefit of humankind" -- Choice, freedom, and the paternalism thing -- Complex ethics: toward an ethics of medicine.
  • "Thinking in Circles About Obesity brings a healthy portion of critical thinking, spiced with on-target humor and lively graphics, to the obesity debate. Systems and medical physiology scholar Tarek Hamid unites systems (non-linear) thinking and information technology to provide insights and practical strategies for managing our weight and our health. Hamid's clear insights dispel dieters' unrealistic expectations and illuminate dead-end behaviors to tap into a deeper understanding how the body works, why it works that way, and how to better manage it." --Book Jacket.
  • Changing paradigms in thiology: from antioxidant defense toward redox regulation / Leopold Flohé -- Mass spectrometry-based methods for the determination of sulfur and related metabolite concentrations in cell extracts / Emmanuel Godat ... [et al.] -- Use of dimedone-based chemical probes for sulfenic acid detection: evaluation of conditions affecting probe incorporation into redox-sensitive proteins / Chananat Klomsiri ... [et al.] -- Use of dimedone-based chemical probes for sulfenic acid detection: methods to visualize and identify labeled proteins / Kimberly J. Nelson ... [et al.] -- Formation and reactions of sulfenic acid in human serum albumin / Beatriz Alvarez ... [et al.] -- Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection / Li-Peng Yap ... [et al.] -- Measurement of mixed disulfides including glutathionylated proteins / Raffaella Priora ... [et al.] -- Detection and quantification of protein disulfides in biological tissues: a fluorescence-based proteomic approach / Viviana I. Pérez ... [et al.] -- Measurement and identification of S-glutathiolated proteins / Bradford G. Hill ... [et al.] -- Proteome screens for Cys residues oxidation: the redoxome / Giovanni Chiappetta ... [et al.] -- Identification by MS/MS of disulfides produced by a functional redox transition / Pierluigi Mauri ... [et al.] -- Mass spectrometry approaches for the redox characterization of protein cysteine residues: the case of the transcription factor Pax-8 / Andrea Scaloni and Gianluca Tell -- A simple method to systematically study oxidatively modified proteins in biological samples and its applications / Byoung-Joon Song, Soo-Kyung Suh and Kwan-Hoon Moon -- Direct and indirect detection methods for the analysis of S-nitrosylated peptides and proteins / Federico Torta, Lisa Elviri and Angela Bachi -- A rapid approach for the detection, quantification, and discovery of novel sulfenic acid or S-nitrosothiol modified proteins using a biotin-switch method / Joseph R. Burgoyne and Philip Eaton -- Protein addicts of aldehydic lipid peroxidation products: identification and characterization of protein adducts using an aldehyde/keto-reactive probe in combination with mass spectrometry / Claudia S. Maier ... [et al.].
  • Engineering of Fluorescent Reporters into Redox Domains to Monitor Electron Transfers / Derek Parsonage ... [et al.] -- Blot-Based Detection of Dehydroalanine-Containing Glutathione Peroxidase with the Use of Biotin-Conjugated Cysteamine / Sue Goo Rhee, Chun-Seok Cho -- Analysis of the Redox Regulation of Protein Tyrosine Phosphatase Superfamily Members Utilizing a Cysteinyl-Labeling Assay / Benoit Boivin, Nicholas K. Tonks -- Measuring the Redox State of Cellular Peroxiredoxins by Immunoblottin / Andrew G. Cox, Christine C. Winterbourn, Mark B. Hampton -- Thiol Redox Transitions by Thioredoxin and Thioredoxin-Binding Protein-2 in Cell Signaling / Eiji Yoshihara ... [et al.] -- Detection of Protein Thiols in Mitochondrial Oxidative Phosphorylation Complexes and Associated Proteins / Kelly K. Andringa, Shannon M. Bailey -- Mitochondrial Thioredoxin Reductase: Purification, Inhibitor Studies, and Role in Cell Signaling / Maria Pia Rigobello, Alberto Bindoli -- Measuring Mitochondrial Protein Thiol Redox State / Raquel Requejo ... [et al.] -- Measurement of Extracellular (Exofacial) Versus Intracellular Protein Thiols / Jolanta Skalska, Steven Bernstein, Paul Brookes -- Redox Clamp Model for Study of Extracellular Thiols and Disulfides in Redox Signaling / Young-Mi Go, Dean P. Jones -- Redox State of Human Serum Albumin in Terms of Cysteine-34 in Health and Disease / Karl Oettl, Gunther Marsche -- Methods for Studying Redox Cycling of Thioredoxin in Mediating Preconditioning-Induced Survival Genes and Proteins / Chuang C. Chiueh -- Oxidative Stress, Thiol Redox Signaling Methods in Epigenetics / Isaac K. Sundar ... [et al.] -- Characterization of Protein Targets of Mammalian Thioredoxin Reductases / Anton A. Turanov, Dolph L. Hatfield, Vadim N. Gladyshev -- Alteration of Thioredoxin Reductase 1 Levels in Elucidating Cancer Etiology / Min-Hyuk Yoo ... [et al.] -- Regulation of Apoptosis Signal-Regulating Kinase 1 in Redox Signaling / Kazumi Katagiri, Atsushi Matsuzawa, Hidenori Ichijo -- Protocols for the Detection of S-Glutathionylated and S-Nitrosylated Proteins In Situ / Scott W. Aesif, Yvonne M.W. Janssen-Heininger, Niki L. Reynaert -- Synthesis, Quantification, Characterization, and Signaling Properties of Glutathionyl Conjugates of Enals / Sanjay Srivastava ... [et al.] -- Thioredoxin and Redox Signaling in Vasculature--Studies Using Trx2 Endothelium-Specific Transgenic Mice / Wang Min ... [et al.]
  • The first IVF conceived birth in 1978 resulted in a significant growth of third party reproductive options which continue to raise ethical, legal, and psychological questions. Third party reproduction procedures can involve as many as five people: sperm donor, egg donor, gestational carrier, and intended parents. Third-Party Reproduction: A Comprehensive Guide utilizes experts in the field to address the medical, psychological, ethical and legal aspects of sperm donation, egg donation, embryo donation, and the use of gestational carriers. In addition, there are chapters on the medical and ethical aspects of posthumous reproduction, religious aspects of third party reproduction, and how to avoid pitfalls of third party reproduction. Aimed at physicians, trainees, psychologists, nurses, and social workers whose practices may include patients considering third party reproduction, the intent of this book is to provide a comprehensive and practical overview of the many aspects of third party reproduction to help all those involved to better understand them. Patients considering third party reproduction may also find value in this book.
  • Print Material
    From Benjamin Franklin to Thomas Eakins : a century of Philadelphia scientists, artists, and provocateurs -- The Agnew Clinic, the Gross Clinic, the Crucifixion, and Swimming : dissecting Eakins' paintings -- Body casts and "anatomical eyes" : Thomas Eakins, William Williams Keen, and the curriculum at the Pennsylvania Academy of the Fine Arts -- Art, pornography, freak shows, medical pictures, and the guilty pleasures of photography in nineteenth-century Philadelphia -- Scandalous exposures : the trials of Thomas Eakins, William Smith Forbes, and Oscar Wilde -- Conclusion : Thomas Eakins' family values.
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  • Introduction to the human genome -- The human genome: gene structure and function -- Human genetic diversity: mutation and polymorphism -- Principles of clinical cytogenetics and genome analysis -- The chromosomal and genomic basis of disease: disorders of the autosomes and sex chromosomes -- Patterns of single-gene inheritance -- Complex inheritance of common multifactorial disorders -- Genetic variation in populations -- Identifying the genetic basis for human disease -- The molecular basis of genetic disease : general principles and lessons from the hemoglobinopathies -- The molecular, biochemical, and cellular basis of genetic disease -- The treatment of genetic disease -- Developmental genetics and birth defects -- Cancer genetics and genomics -- Risk assessment and genetic counseling -- Prenatal diagnosis and screening -- Application of genomics to medicine and personalized health care -- Ethical and social issues in genetics and genomics.
  • Print Material
    1. Surgical technique and a clinical study on 79 patients.
  • Thoracic imaging 2010
    Congenital disorders -- Disorders of the airways -- Occupational diseases -- Infections -- Idiopathic interstitial pneumonia -- Collagen diseases and vasculitis -- Immune disorders and disorders of uncertain etiology -- Bronchopulmonary neoplasms -- Disorders of the pulmonary circulatory system -- Mediastinal disorders -- Chest wall and pleura -- Chest trauma -- Sequelae of therapy.
  • Thoracic imaging 2011
    Thieme Book
  • "Thoracic Imaging: Case Review, by Phillip M. Boiselle, MD, Theresa C. McLoud, MD and Gerald F. Abbott, MD, tests your ability to interpret a wide range of images seen in practice. The completely revised edition of this title in the popular Case Review series features all-new cases and superb-quality accompanying images that explore the newest imaging modalities, including new treatment guidelines for lung cancer, HIV/AIDS, and pneumonia. This complete study of thoracic imaging has been organized for quick reference and easy board and recertification review. Easily find and study the most challenging topics from among approximately 200 cases-organized by difficulty - and 400 images - with questions and answers, diagnoses, commentary, references, and cross-references to Thoracic Radiology: The Requisites."--Publisher's website.
  • Thoracic outlet syndrome (TOS) is a condition estimated to affect as many as 80 of every 1000 patients in the US alone. While estimates vary widely based in part on lack of consensus as to the definition of the syndrome, as many as 3000 first rib resections are performed annually in the US. TOS comprises at least three separate conditions. The most common, neurogenic TOS, refers to the condition where the brachial plexus is compressed at the scalene triangle or retropectoral space, and is manifest as local and extremity pain and neurologic symptoms. Venous TOS refers to the situation where the subclavian vein is compressed by the structures making up the costoclavicular junction, and presents as acute or chronic venous thrombosis or injury or occasionally intermittent positional obstruction. Finally, arterial TOS refers to the situation where arterial injury occurs as the result of abnormal bony or ligamentous structures at the outlet, and presents as occlusion of or embolization from an abnormal artery in this area. Thoracic Outlet Syndrome brings together many experts who treat this disease and are leaders in their fields. While it can certainly be read in its entirety (and should, by all who concentrate on this condition), it is designed to be a clinical reference, residing on a shelf in a busy surgical, vascular or neurologic clinic where individual chapters can be quickly referenced. As such, the chapters are thorough, but concise and useful to answer when a specific question arises in the course of daily practice.
  • Normal lung -- Incidental findings -- Developmental and pediatric diseases -- Pediatric tumors -- Obstructive lung (airway) diseases -- Restrictive (interstitial) lung diseases -- Granulomatous diseases (non-infectious) -- Smoking related diseases -- Miscellaneous diseases -- Diseases of vascular origin -- Pulmonary infections -- Complications of therapies -- Tumors of lung -- Nonneoplastic diseases -- Neoplastic diseases -- Normal thymus -- Nonneoplastic diseases -- Thymoma -- Other thymic tumors -- Inflammatory infectious lesions -- Cystic lesions -- Ectopic lesions -- Tumors -- Normal heart -- Congenital heart disease -- Valvular diseases -- Mycocardial diseases -- Ischemic heart disease -- Heart transplantation -- Infections -- Tumors of the heart -- Diseases of vessels.
  • Thoracic radiology : imaging methods, radiographic signs, and diagnosis of chest disease / McLoud, Aquino -- Congenital abnormalities of the thorax / McLoud, Boiselle -- Pulmonary infections in the normal host / McLoud, Boiselle -- Pulmonary diseases in the immunocompromised host with or without acquired immunodeficiency syndrome / McLoud, Boiselle -- Radiography for the critical care patient / Trotman-Dickenson -- Thoracic trauma / Trotman-Dickenson, Ledbetter -- Interstitial lung disease / McLoud, Digumarthy -- The pneumoconioses / McLoud, Digumarthy -- Diseases of altered immunologic activity / McLoud, Boiselle, Trotman-Dickenson -- Chronic obstructive pulmonary disease and asthma / McLoud, Boiselle -- Pulmonary neoplasms / McLoud, Digumarthy -- The trachea / Digumarthy, Shepard -- The bronchi / Digumarthy, Shepard -- Pulmonary vascular abnormalities / Boiselle, Wittram -- The mediastinum : anatomy / Boiselle -- Mediastinal masses / Boiselle -- Diffuse mediastinal abnormalities / Boiselle -- The pleura / McLoud, Boiselle -- Interventional techniques / McLoud, Digumarthy.
  • Thoracic surgery atlas 2007
    Incisions -- Minimally invasive approaches -- Lung -- Chest wall -- Mediastinum -- Esophagus -- Thoracic duct -- Sympathetic chain -- Diaphragm -- Major airways -- Pleura.
  • Section 1. General principles -- Section 2. Imaging -- Section 3. Anesthetic management -- Section 4. Treatment strategies and techniques -- Section 5. Specific problems -- Section 6. Advances in prosthetic management.
  • The incidence of pleural disease is increasing, and it is now accepted that best practice requires the incorporation of thoracoscopy into the work-up. However, surgeons cannot meet the rising demand for thoracoscopy by means of video-assisted thoracoscopic surgery (VATS), and waiting lists for endoscopic pleural procedures are consequently lengthening. Against this background, there is an increasing need for medical thoracoscopy performed by pulmonologists, which may be video assisted and has the advantage of being very cost-effective. This book is a comprehensive and up-to-date guide to thoracoscopy for pulmonologists that documents the considerable progress in endoscopic telescopes and instrumentation. Clear practical guidance is provided on technique, and diagnostic, therapeutic, and interventional applications of thoracoscopy are all carefully examined with the aid of high-quality illustrations. Although medical thoracoscopy is much less invasive than VATS and thoracotomy, complications can occur in a small number of cases; these are discussed and advice on prevention is provided. The concluding section examines the future of the field, covering developments such as 'mini' thoracoscopy, autofluorescence thoracoscopy, and flexi-rigid thoracoscopy.
  • Thought suppression 2005
  • From 3-D volumetric computer tomography to 3-D cephalometry / Filip Schutyser, Johan Van Cleynenbreugel -- Basic craniofacial anatomical outlines / Gwen R.J. Swennen -- 3-D cephalometric reference system / Gwen R.J. Swennen -- 3-D cephalometric hard tissue landmarks / Gwen R.J. Swennen -- 3-D cephalometric soft tissue landmarks / Gwen R.J. Swennen -- 3-D cephalometric planes / Gwen R.J. Swennen -- 3-D cephalometric analysis / Gwen R.J. Swennen -- 3-D cephalometry and craniofacial growth / Gwen R.J. Swennen -- Clinical applications / Gwen R.J. Swennen -- Future perspectives of 3-D cephalometry / Gwen R.J. Swennen, Filip Schutyse.
  • Three-dimensional echocardiography is the most recent fundamental advancement in echocardiography with a strong impact on almost all clinical and research applications of echocardiography. After a very successful 1st edition, this book presents the fully revised 2nd edition. Accounting for the marked progress of real-time 3D echocardiography since the 1st edition it covers all clinically important aspects of this fascinating new technology, including a comprehensive explanation of its basic principles, practical aspects of clinical application, new recommendations in recent guidelines, and detailed descriptions of specific uses in the broad spectrum of clinically important heart disease. The book was written by a group of well-recognized international experts in the field, who have not only been involved in scientific and clinical evolution of 3D echocardiography since its beginnings but are also intensely involved in expert training courses. As a result, the clear focus of this book is on the practical application of 3D echocardiography in daily clinical routine with tips and tricks for both beginners and experts, all accompanied by more than 150 case examples comprehensively illustrated with more than 850 images and more than 500 videos available on a DVD. In concert with an in-depth review and comprehensive update of the most recent literature on real-time 3D echocardiography, this book continues to represent an invaluable reference on 3D echocardiography for beginners and expert users.
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    Postconception -- Touching the brain -- Embryonic period -- Watching the brain -- Fetal period -- Mining the brain -- Childhood -- The dreaming brain -- Adolescence -- Multiple minds -- Adulthood -- Mind and magic -- Old age -- Open mind -- Death -- Mind and body.
  • 1. Thromboembolism in Orthopedic Surgery: Scope of the Problem / Bengt I. Eriksson and Ola E. Dahl -- 2. Incidence of Venous Thromboembolism in Orthopedic Surgery / Ajay K. Kakkar and Sophie K. Rushton-Smith -- 3. Specific Risk Factors for Venous Thromboembolism in Orthopedics / Lasse J. Lapidus -- 4. Diagnosis and Treatment of Deep Vein Thrombosis and Pulmonary Embolism After Major Joint Surgery / Manuel Monreal and Juan I. Arcelus -- 5. Drugs for Thromboprophylaxis: Unfractionated Heparin, Low Molecular Weight Heparin, Warfarin, and Fondaparinux / José Aguirre and Alain Borgeat -- 6. New Drugs for Thromboprophylaxis: Apixaban, Dabigatran, Rivaroxaban / Raquel Ferrandis -- 7. Effectiveness of Mechanical Devices in Orthopedic Surgery / David J. Warwick -- 8. Anesthetic Implications of Thromboprophylaxis / Sibylle A. Kozek-Langenecker -- 9. Thromboprophylaxis in High-Risk Orthopedic Surgery: Total Hip and Knee Arthroplasty and Hip Fracture / Juan V. Llau and Raquel Ferrandis -- 10. Thromboprophylaxis in Day Surgery: Knee Arthroscopy and Ligamentoplasty (Ligament Reconstruction) / James E. Muntz, Steven E. Flores, and Walter R. Lowe -- 11. Thromboprophylaxis in Special Patients: Multiple Trauma, Head Trauma, and Spine Surgery / Maria J. Colomina, Lidia Mora, and Esther Ciércoles -- 12. Management of Antiaggregated and Anticoagulated Patients Scheduled for Orthopedic Surgery / Raquel Ferrandis and Juan V. Llau.
  • 1. Mechanisms of thrombosis -- 2. Pharmacokinetics and pharmacodynamics of fibrinolytic agents -- 3. Thrombolytic therapy: evidence-based results from multicenter control trials -- 4.Patients for thrombolysis -- 5. Anticoagulation as adjunctive treatment and one-hour alteplase infusion -- 6. Current guidelines and recommendations for thrombolysis use in pulmonary embolism -- 7. Thrombolysis in pulmonary embolism -- 8. Thrombolysis in special situations -- Index.
  • Print Material
    The normal lung / Charles Kuhn III and Joanne L. Wright -- Lung growth and development / Monique E. De Paepe -- Quantitative anatomy of the lung / Joanne L. Wright and William M. Thurlbeck -- Lung biopsy, lung resection, and autopsy lung specimens : handling and diagnosis limitations / Andrew M. Churg -- Special techniques / Joanne L. Wright -- Pulmonary disorders in the neonate, infant, and child / Claire Langston -- Bacterial infections of the lungs and upper airways / Gary W. Procop and Henry D. Tazelaar -- Tuberculosis and other mycobacterial infections of the lung / Gary W. Procop and Henry D. Tazelaar -- Viral infections of the respiratory tract / Gary W. Procop and Henry D. Tazelaar -- Fungal diseases, including pneumocystis / Richard E. Sobonya -- Protozoal and helminthic pulmonary disease / Richard Fraser -- Alveolar hemorrhage / Samuel A. Yousem -- Pulmonary edema / James C. Hogg -- Adult respiratory distress syndrome / Joanne L. Wright -- Wegener's granulomatosis / Samuel A. Yousem -- Churg-Strauss syndrome, microscopic polyangiitis, and other forms of pulmonary vasculitis / Andrew M. Churg -- Carcinoma of the lung / Philip T. Cagle -- Uncommon tumors of the lung / Henry D. Tazelaar -- Lymphoproliferative disorders / Andrew G. Nicholson -- Idiopathic interstitial pneumonias / Jeffrey L. Myers -- Other diffuse lung diseases / Jeffrey L. Myers -- Chronic airflow obstruction / Joanne L. Wright -- Lung transplant pathology / Philip T. Cagle -- Occupational lung disease / Andrew M. Churg and Francis H.Y. Green -- Pulmonary vascular disease / J. Michael Kay -- Diseases of the pleura / Andrew M. Churg -- Diagnostic lung cytology / Roger Amy.
  • The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
  • Thyroid cancer 2012
    The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the United States, with three-quarters occurring in women. The overall 5-year survival rate is about 97%, making it one of the least lethal cancers. We are experiencing an epidemic of well-differentiated thyroid cancer, in part due to the widespread use of imaging modalities that detect thyroid nodules and microcarcinomas. Concurrently, there have been a number of recent advances in surgical treatment, as well as diagnostic modalities that allow us to detect small amounts of residual local and metastatic disease. Additionally, a reexamination of past treatment regimens has led to new recommendations regarding the use of radioactive iodine, and to new therapeutic options, such as targeted therapy which have supplanted the use of more toxic chemotherapy for metastatic cancer. Multiple academic organizations have developed consensus guidelines for the management of thyroid cancer, occasionally with conflicting recommendations. In Thyroid Cancer, a renowned group of authors presents a broad overview of the pathology, pathophysiology, diagnosis, and management of thyroid cancer, with an emphasis on recent evidence-based information. State-of-the-art and a significant contribution to the literature, Thyroid Cancer is an invaluable reference for endocrinologists, oncologists, nuclear medicine physicians, radiation oncologists, primary care physicians, and surgeons who deal with head and neck cancer.
  • "Thyroid cancer evaluation and treatment has enjoyed very little evolution in comparison with other disease management strategies. The standard treatment algorithms for thyroid cancer have varied only in response to major, though infrequent, biotechnological innovations. These resultant algorithm node insertions produced paradigm changes, but there has been little to advance the care of the patient with advanced thyroid cancer--until very recently. Perhaps the reasons for a relative lack of interest and scientific progress are the overwhelming likelihood of benignity among thyroid nodules, the overwhelmingly favorable clinical outcome even if a patient has thyroid cancer, and the overwhelming long time required for clinical follow-up of these cancer patients. Unfortunately, the problem now is that we may be overmanaging low-risk patients, and we have not achieved the clinical responses we would have liked with high-risk patients"--Provided by publisher.
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    Introduction / J. Martin Miller and Max Wisgerhof -- Techniques of fine-needle aspiration biopsy / J. Martin Miller and Max Wisgerhof -- Cytopreparatory techniques -- Specimen adequacy and asessment, reporting scheme -- Concepts basic to thyroid cytopathology and guidelines for evaluating thyroid fine-needle aspirates -- Nodular goiter -- Follicular adenoma and follicular carcinoma -- Hürthle cell lesions -- Papillary carcinoma -- Poorly differentiated "insular" carcinoma -- Anaplastic carcinoma -- Medullary carcinoma -- Thyroiditis -- Malignant lymphoma -- Thyroid carcinomas metastatic to other body sites -- Metastatic malignancy to the thyroid -- Cysts and cystic lesions of the thyroid -- Spindle cells in thyroid aspirates -- Miscellaneous lesions of the thyroid -- Infarction of thyroid neoplasms following fine-needle biopsy -- Lesions of the parathyroid glands -- Ancillary diagnostic techniques / Osama Alassi ... [et al.] -- Application of needle biopsy data to management decisions / J. Martin Miller.
  • Foreword vii -- Preface -- Acknowledgments -- Part 1. Physiology, testing, and common thyroid disorders -- Introduction -- Thyroid testing and imaging -- Graves' disease -- Other causes of hyperthyroidism -- Thyroid ophthalmopathy -- Hypothyroidism -- Subclinical thyroid disease -- Hashimoto's thyroiditis -- Thyroid disease in pregnancy and post partum -- Thyroid disease in children and adolescents -- Thyroid nodules and cancer -- Management of thyroid cancer patients -- Part 2. Challenging thyroid disorders and current controversies -- Challenging cases of hyperthyroidism -- Treatment of Graves' disease: a personal perspective -- Iatrogenic hyperthyroidism -- Final thoughts -- Index.
  • This book covers the entire spectrum of thyroid diseases in childhood, focusing on the recent advances that have been achieved, from progress in basic science research through to novel or improved approaches to diagnosis and treatment. Introductory chapters discuss thyroid embryogenesis and the role of thyroid hormones in fetal development. The two contrasting forms of thyroid dysfunction, hypo- and hyperthyroidism, are then considered in depth, with particular attention to the molecular causes of congenital hypothyroidism. Among the other topics addressed are autoimmune thyroiditis, thyroid nodules, and pediatric neoplasms. The book concludes with an overview of promising therapeutic approaches, such as stem cell therapy. Each topic is treated by an eminent expert in the field, ensuring consistently high quality. Thyroid Diseases in Childhood will be an important source of information for endocrinologists, pediatricians, oncologists, and gynecologists, as well as other professionals interested in this topic.
  • Anatomy and Embryology of the Thyroid Gland / Gabriel Wong and Scott Schaffer -- Hormones / Airani Sathananthan, Kimberly A. Placzkowski and John C. Morris -- Classification and Epidemiology of Thyroid Disease / Ghada Haddad and Steven Kaufman -- Laboratory Diagnosis of Thyroid Disease / Reagan Schiefer and Vahab Fatourechi -- Thyroglossal Duct Cysts / Lisa M. Reid -- Thyroid Cancer and the Skin / Robert A. Somer and Nati Lerman -- Chromosomes, Genes, and the Thyroid Gland / Analisa V. Halpern and Rhonda E. Schnur -- Cutaneous Manifestations of Hyperthyroidism / Clara-Dina Cokonis, Carrie W. Cobb, Warren R. Heymann and Chad M. Hivnor -- Cutaneous Manifestations of Hypothyroidism / Sandra A. Kopp, Pascal G. Ferzli, Chad M. Hivnor and Warren R. Heymann -- Pretibial Myxedema (Thyroid Dermopathy) / Vahab Fatourechi -- Alopecia and Thyroid Disease / Michelle Babb-Tarbox and Wilma F. Bergfeld -- Chronic Idiopathic Urticaria and Thyroid Disease / Jeffrey S Rumbyrt and Alan L Schocket -- Dermatologic Disorders Associated with Thyroid Disease / Joslyn Sciacca Kirby and William D. James -- Potential Therapeutic Uses of Thyroid Hormone / Joshua D. Safer and Michael F. Holick.
  • Thyroid eye disease 2015
    This book offers ophthalmologists and medical practitioners a concise, data-driven review of the information that is most relevant in guiding the diagnosis and management of thyroid eye disease (TED). Particular attention is devoted to research and clinical trials that have advanced the field in recent years. Progress in our understanding of the pathogenesis of TED is described, and the heterogeneous natural history of TED is discussed to facilitate preemptive interventions. Advances in diagnostic evaluation, including autoantibody assessment, are reviewed with regard to their clinical utility. The diagnostic features of euthyroid TED are also carefully covered since these patients often represent a diagnostic dilemma. All relevant aspects of treatment are addressed including the role of radioactive iodine, long-term medical therapy, and surgical thyroidectomy. The impact of these treatment modalities on eye disease are discussed. Management of active TED is reviewed according to the severity of disease and in the light of recent findings and the introduction of novel agents. The discussion encompasses the role of steroids and other agents, the use of novel biologics, the medical and surgical treatment of optic neuropathy, and minimally invasive, customized reconstructive surgery. Numerous supporting images are included, and helpful checklists will aid the practitioner in treatment decision making.
  • Thyroid Hormone Metabolism / Stephen A. Huang and Luciana A. de Castro Neves -- Genetic Influences on Thyroid Function Tests / Wendy M. van der Deure, Marco Medici, Robin P. Peeters and Theo J. Visser -- Influence of Iodine Deficiency and Excess on Thyroid Function Tests / Maria Andersson and Michael B. Zimmermann -- Regulation of Thyroid Hormone Production and Measurement of Thyrotropin / Jerome M. Hershman -- Measurements of Thyroxine and Triiodothyronine / Jim R. Stockigt -- Thyroid Autoantibody Measurement / R. A. Ajjan and A. P. Weetman -- Thyroglobulin Measurement / Carole Spencer and Ivana Petrovic -- Thyroid Function Testing in Ambulatory Practice / Angela M. Leung and Alan P. Farwell -- Assessing Thyroid Function in Infants and Children / Alicia G. Marks and Stephen H. LaFranchi -- Assessing Thyroid Function in Hospitalized Patients / Jonathan S. LoPresti and Komal S. Patil -- Assessing Thyroid Function in Pregnancy / John H. Lazarus, Offie P. Soldin and Carol Evans -- Assessing Thyroid Function in the Elderly / Mary H. Samuels -- Influence of Drugs on Thyroid Function Tests / Sonia Ananthakrishnan and Elizabeth N. Pearce.
  • Murine models for the study of thyroid gland development / M. De Felice, R. Di Lauro -- Familial forms of thyroid dysgenesis / M. Castanet, M. Polak, J. Léger -- Possible non-Mendelian mechanisms of thyroid dysgenesis / J. Deladoëy, G. Vassart, G. Van Vliet -- Thyroid imaging in children / C. Garel, J. Léger -- Clinical and biological consequences of iodine deficiency during pregnancy / D. Glinoer -- Ontogenesis of thyroid function and interactions with maternal function / M.J. Obregon ... [et al.] -- New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations / J.C. Moreno, T.J. Visser -- Thyroid hormone transporter defects / A. Grüters -- Novel biological and clinical aspects of thyroid hormone metabolism / A.M. Dumitrescu, S. Refetoff -- Papillary and follicular thyroid cancers in children / V. Vasko ... [et al.] -- Hereditary medullary thyroid carcinoma: how molecular genetics made multiple endocrine neoplasia type 2 a paediatric disease / G. Szinnai, S. Sarnacki, M. Polak.
  • Thyroid neoplasms 2005
    Gene rearrangements in thryoid cancer -- Molecular markers of thyroid nodules -- Ultrasound in the diagnosis and management of thyroid cancer -- Controversies in the use of radioiodine for remnant ablation and therapy of thyroid carcinoma -- Thyroglobulin measurements in thryoid cancer evaluation and surveillance -- The role of fluoro-deoxy glucose (FDG) positron emission tomorgraphy (PET) in the management of differentiated thyroid cancer -- Preclinical studies of chemotherapy for undifferentiated thyroid carcinoma -- Medullary thyroid carcinoma -- Thyroid neoplasms in children and adolescents.
  • History of Thyroid Ultrasound / Robert A. Levine -- Thyroid Ultrasound Physics / Robert A. Levine -- Doppler Ultrasound of the Neck / Robert A. Levine -- Normal Neck Anatomy and Method of Performing Ultrasound Examination / Dara R. Treadwell -- Pediatric Ultrasound of the Neck / Henry J. Baskin Jr -- Ultrasound of Diffuse Thyroid Enlargement: Thyroiditis / Mark A. Lupo and Robert A. Levine -- Ultrasound of Nodular Thyroid Enlargement / Susan J. Mandel and Jill E. Langer -- Ultrasound and Mapping of Neck Lymph Nodes / Gregory Randolph, Barry Sacks and H. Jack Baskin Sr -- Ultrasonography of the Parathyroid Glands / Dev Abraham -- Surgical Trends in Treatment of Thyroid Nodules, Thyroid Cancer, and Parathyroid Disease / Haengrang Ryu, Rachel Harris and Nancy D. Perrier -- Ultrasound of Salivary Glands and the Non-endocrine Neck / Robert A. Sofferman -- Ultrasound-Guided Fine-Needle: Aspiration of Thyroid Nodules / Daniel S. Duick -- Laser and Radiofrequency Ablation Procedures / Roberto Valcavi, Giorgio Stecconi Bortolani and Fabrizio Riganti -- Percutaneous Ethanol Injection (PEI) in the Treatment of Thyroid Cysts, Nodules, and Other Neck Lesions / Andrea Frasoldati and Roberto Valcavi -- Ultrasound-Guided FNA and Molecular Markers for Optimization of Thyroid Nodule Management / Daniel S. Duick -- Ultrasound Elastography of the Thyroid / Robert A. Levine -- Authoring Quality Ultrasound Reports / J. Woody Sistrunk and H. Jack Baskin Sr.
  • History of transient ischemic attack definition / Mohr, J.P. -- The concept of acute cerebrovascular syndrome / Uchiyama, S. -- Transient ischemic attack as a medical emergency / Okada, Y. -- TIA clinic : a major advance in management of transient ischemic attacks / Lavalle, P.; Amarenco, P. -- Risk scores for transient ischemic attack / Wolf, M.E.; Held, V.E.; Hennerici, M.G. -- Epidemiology of transient ischemic attack / Kokubo, Y. -- Symptoms of transient ischemic attack / Kim, J.S. -- Guidelines for management of patients with transient ischemic attack / Uehara, T.; Minematsu, K. -- Radiological examinations of transient ischemic attack / Tung, C.E.; Olivot, J.M.; Albers, G.W. -- Neurosonological examinations of transient ischemic attack / Sharma, V.K.; Wong, K.S.L. -- Stroke subtypes and interventional studies for transient ischemic attack / Lavalle, P.; Amarenco, P. -- Antithrombotic therapy in transient ischemic attack patients / Held, V.E.; Wolf, M.E.; Hennerici, M.G.
  • The responsibilities of being a physiotherapist / Ralph Hammond and Ceri Sedgley -- Inter-professional education and team working / Alison Chambers .̤ [et al.] -- Clinical leadership and professionalism / Alison Chambers -- Pharmacology for physiotherapists / Nicholas Southorn -- Reflection / Linda Hollingworth, Sarah Dunbar, and Lindsey Dugdill -- Respiratory diseases / Stephanie Enright and Fiona Schreuder -- Adult spontaneous and conventional mechanical ventilation / Sue Pieri-Davies, Helen Carruthers, and Melanie Reardon -- Cardiac and pulmonary rehabilitation / Sushma Sanghivi -- Physiotherapy in cardiothoracic surgery / Anne Dyson and Kelly Youd -- Changing relationships for changing health / Sally French and John Swain -- Musculoskeletal assessment / Lynne Gaskell -- Tissue inflammation and repair / Janette Grey -- Exercise in rehabilitation / Duncan Mason -- Muscle imbalance / Alan Chamberlain, Wendy Munro and Alex Rickard -- Biomechanics / Jim Richards, Renuka Erande and Ambreen Chohan -- Sports management / Hilary Pape -- Pain / Lester Jones, Lorimer Moseley, Catherine Carus -- Acupuncture / Andrew Bannan -- Electrotherapy / Tim Watson -- Physiotherapy for people with amputation / Carolyn Hale -- Massage / Joan watt -- An introduction to fractures / Annie Karim -- Upper and lower limb joint arthroplasty / Ann Price -- Older people / Bhanu Ramaswamy and Paula McCandless -- Neurodynamics / Monika Lohkamp, Katie Small, and Lee Herrington -- Neurological physiotherapy / Christine Smith, Anita Watson, and Louise Connell -- Physiotherapy in women's health / Gill Brook ... [et al.].
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  • "As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics."--Publisher's website.
  • Tight junctions 2006
    Evolution of the transporting epithelium phenotype / Marcelino Cereijido ... [et al.] -- Occludin, a constituent of tight junctions / Yan-Hua Chen, Daniel A. Goodenough and Qun Lu -- Tight junction channels / James Melvin Anderson and Christina M. Van Itallie -- JAM family proteins: tight junction proteins that belong to the immunoglobulin superfamily / Susumu Hirabayashi and Yutaka Hata -- Cingulin, a cytoskeleton-associated protein of the tight junction / Laurent Guillemot and Sandra Citi -- ZO proteins and tight junction assembly / Alan S. Fanning -- TJ proteins that make round trips to the nucleus / Esther Lopez-Bayghen ... [et al.] -- Tight junctions and the regulation of epithelial -- Cell proliferation and gene expression / Emma Kavanagh ... [et al.] -- Tight junction proteins and cancer / Isabel J. Latorre, Kristopher K. Frese and Ronald T. Javier -- Regulation of paracellular transport across tight junctions by the actin cytoskeleton / Matthias Bruewer and Asma Nusrat -- Regulation of tight junctions' functional integrity: role of a urinary factor, lipids, and ouabain / Liora Shoshani ... [et al.] -- Tight junctions during development / Bhavwanti Sheth ... [et al.] -- Tight junctions and the blood-brain barrier / Hartwig Wolburg, Andrea Lippoldt, and Klaus Ebnet -- Tight junctions in CNS myelin / Jeff M. Bronstein and Seema Tiwari-Woodruff -- Tight junction modulation and its relationship to drug delivery / Noha N. Salama, Natalie D. Eddington and Alessio Fasano.
  • There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells.
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    PTSD and time perspective therapy. How PTSD sufferers get stuck in time -- A new psychology of time -- Time perspective therapy -- The stories. War veterans, PTSD, and time perspective therapy -- Everyday trauma, PTSD, and time perspective therapy -- Women, PTSD, and time perspective therapy -- Appendix A: How TPT compares with other approaches -- Appendix B: Clinical trial: TPT pilot study research data -- Appendix C: Client psychological test scores.
  • "Recent advances in brain science measurement technology have given researchers access to very large-scale time series data such as EEG/MEG data (20 to 100 dimensional) and fMRI (140,000 dimensional) data. To analyze such massive data, efficient computational and statistical methods are required. Time Series Modeling of Neuroscience Data shows how to efficiently analyze neuroscience data by the Wiener-Kalman-Akaike approach, in which dynamic models of all kinds, such as linear/nonlinear differential equation models and time series models, are used for whitening the temporally dependent time series in the framework of linear/nonlinear state space models. Using as little mathematics as possible, this book explores some of its basic concepts and their derivatives as useful tools for time series analysis. Unique features include: statistical identification method of highly nonlinear dynamical systems such as the Hodgkin-Huxley model, Lorenz chaos model, Zetterberg Model, and more Methods and applications for Dynamic Causality Analysis developed by Wiener, Granger, and Akaike state space modeling method for dynamicization of solutions for the Inverse Problems heteroscedastic state space modeling method for dynamic non-stationary signal decomposition for applications to signal detection problems in EEG data analysis An innovation-based method for the characterization of nonlinear and/or non-Gaussian time series An innovation-based method for spatial time series modeling for fMRI data analysis The main point of interest in this book is to show that the same data can be treated using both a dynamical system and time series approach so that the neural and physiological information can be extracted more efficiently. Of course, time series modeling is valid not only in neuroscience data analysis but also in many other sciences and engineering fields where the statistical inference from the observed time series data plays an important role"--Provided by publisher.
  • As we consider ways to improve our nation's overall health, we must consider options that will improve opportunities for all, with special emphasis on lifting up low-income children and those who are in danger of being left behind. A stronger, healthier America hinges on our ability to build a sustainable foundation for generations to come.
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  • Tinnitus 2012
    Historical Reflections on Current Issues in Tinnitus / Jos J. Eggermont and Fan-Gang Zeng -- Behavioral Tests for Tinnitus in Animals / Henry E. Heffner and Rickye S. Heffner -- Molecular Mechanism of Tinnitus / Marlies Knipper, Marcus Müller and Ulrike Zimmermann -- The Cochlea and the Auditory Nerve as a Primary Source of Tinnitus / Régis Nouvian, Michel Eybalin and Jean-Luc Puel -- Dorsal Cochlear Nucleus: Somatosensory-Auditory Interactions in Tinnitus / Susanne Dehmel, Seth D. Koehler and Susan E. Shore -- The Inferior Colliculus: Involvement in Hyperactivity and Tinnitus / Donald Robertson and Wilhelmina Mulders -- Cortex: Way Station or Locus of the Tinnitus Percept? / Jos J. Eggermont -- Human Brain Imaging of Tinnitus / Jennifer R. Melcher -- The Psychophysics of Tinnitus / Brian C. J. Moore -- Stimulating the Auditory System to Treat Tinnitus: From Alleviating the Symptoms to Addressing the Causes / Arnaud J. Noreña -- Treatment: Pharmacological, Repetitive Transcranial Magnetic Stimulation, Epidural Stimulation, and Deep Brain Stimulation / Berthold Langguth, Dirk De Ridder, Tobias Kleinjung and Ana Belén Elgoyhen.
  • 2011 AccessMedicine
    Section 1. Prehospital Care -- Section 2. Disaster Preparedness -- Section 3. Resuscitation -- Section 4. Resuscitative Procedures -- Section 5. Analgesia, Anesthesia, and Procedural Sedation -- Section 6. Emergency Wound Management -- Section 7. Cardiovascular Disease -- Section 8. Pulmonary Emergencies -- Section 9. Gastrointestinal Emergencies -- Section 10. Renal and Genitourinary Disorders -- Section 11. Obstetrics and Gynecology -- Section 12. Pediatrics -- Section 13. Infectious Diseases -- Section 14. Neurology -- Section 15. Toxicology -- Section 16. Environmental Injuries -- Section 17. Endocrine Emergencies -- Section 18. Hematologic and Oncologic Emergencies -- Section 19. Eyes, Ears, Nose, Throat, and Oral Surgery -- Section 20. Skin Disorders -- Section 21. Trauma -- Section 22. Injuries to Bones and Joints -- Section 23. Musculoskeletal Disorders -- Section 24. Psychosocial Disorders -- Section 25. Abuse and Assault -- Section 26. Special Situations -- Section 27. Principles of Imaging. Videos of Procedures: -- Dix-Hallpike Maneuver (4 min., 55 sec.) -- Epley Maneuver (3 min., 52 sec.) -- Ultrasound: Basilic Vein Cannulation (5 min., 17 sec.) -- The Knee Exam (10 min., 52 sec.) -- Lumbar Puncture Decubitus Position (10 min., 11 sec.) -- NIH Stroke Scale (18 min., 3 sec.) -- Posterior Leg Splint (2 min., 19 sec.) -- Chest Tube Insertion (10 min.).
  • Tintinalli's Emergency medicine. 7th edition, 7th/8th ed. 2011
    AccessEmergency Medicine
    Advanced airway support -- Arrhythmia management -- Resuscitation of children and neonates -- Fluids, electrolytes, and acid-base disorders -- Therapeutic approach to the hypotensive patient -- Anaphylaxis, acute allergic reactions, and angioedema -- Acute pain management and procedural sedation -- Management of patients with chronic pain -- Evaluation and preparing wounds -- Methods for wound closure -- Lacerations to the face and scalp -- Injuries of the arm, hand, fingertip, and nail -- Lacerations to the leg and foot -- Soft tissue foreign bodies -- Puncture wounds and mammalian bites -- Post repair wound care -- Chest pain: cardiac or not -- Acute coronary syndromes: management of myocardial infarction and unstable angina -- Cardiogenic shock -- Low probability acute coronary syndromes -- Syncope -- Congestive heart failure and acute pulmonary edema -- Valvular emergencies -- The cardiomyopathies, myocarditis, and pericardial disease -- Thromboembolism -- Systemic and pulmonary hypertension -- Aortic dissection and aneurysms -- Occlusive arterial disease -- Respiratory distress -- Bronchitis, pneumonia, and SARS -- Tuberculosis -- Spontaneous and latrogenic pneumothorax -- Hemoptysis -- Asthma and chronic obstructive pulmonary disease -- Acute abdominal pain -- Nausea and vomiting -- Disorders presenting primarily with diarrhea -- Acute and chronic constipation -- Gastrointestinal bleeding -- Esophageal emergencies -- Peptic ulcer disease and gastritis -- Pancreatitis and cholecystitis -- Acute appendictis -- Diverticulitis -- Intestinal obstruction and volvulus -- Hernia in adults and children -- Anorectal disorders -- Jaundice, hepatic disorders, and hepatic failure -- Complications of general surgical procedures -- Acute renal failure -- Rhabdomyolysis -- Emergencies in renal failure and dialysis patients -- Urinary tract infections and hematuria -- Acute urinary retention -- Male genital problems -- Urologic stone disease -- Complications of urologic devices -- Vaginal bleeding and pelvic pain in the nonpregnant patient -- Ectopic pregnancy and emergencies in the first 20 weeks -- Comorbid diseases in pregnancy -- Emergencies after 20 weeks pregnancy and the postpartum period -- Emergency delivery -- Vulvovaginitis -- Pelvic inflammatory disease and tube-ovarian abscess -- Complications of gynecologic procedures -- Fever and serious bacterial illness in children -- Common neonatal problems -- Common infections of the ear, nose, neck, and throat -- Upper respiratory emergencies-stridor and drooling -- Wheezing in infants and children -- Pneumonia in infants and children -- Pediatric heart disease -- Vomiting and diarrhea infants and children -- Pediatric abdominal emergencies -- Pediatric urinary tract infections -- Seizures and status epilepticus in children -- Headache and altered mental status in children -- Syncope and sudden death in children and adolescents -- Hypoglycemia and metabolic emergencies in infants and children -- The diabetic child -- Fluid and electrolye therapy -- Musculoskeletal disorders in children -- Rashes in infants and children -- Sickle cell anemia in children -- Hematologic-oncologic emergencies in children -- Renal emergencies in infants and children -- Sexually transmitted diseases -- Toxic shock -- Septic shock -- Soft tissue infections -- Disseminated viral infections -- HIV infections and AIDS -- Infective endocarditis -- Tetanus and rabies -- Malaria -- Foodborne and waterborne diseases -- Zoonotic infections -- World travelers -- The transplant patient -- General management of the poisoned patient -- Anticholinergic toxicity -- Psychopharmacologic agents -- Sedatives and hypnotics -- Alcohols -- Drugs of abuse -- Analgesics -- Xanthines and nicotine -- Cardiac medications -- Anticonvulsants -- Iron -- Hydrocarbons and volatile substances -- Caustics -- Pesticides -- Metals and metalloids -- Industrial toxins and cyanide -- Herbals and vitamins -- Dyshemoglobinemias -- Frostbite and hypothermia -- Heat emergencies -- Bites and stings -- Trauma and envenomation from marine fauna -- High-altitude medical problems -- Dysbarism and complications of diving -- Near drowning -- Thermal and chemical burns -- Electrical and lightning injuries -- Carbon monoxide -- Mushroom and plant poisoning -- Diabetic emergenices -- Alcoholic ketoacidosis -- Thyroid disease emergencies -- Adrenal insufficiency and adrenal crisis -- Evaluation of anemia and the bleeding patient -- Acquired bleeding disorders -- Hemophilias and von Willebrand disease -- Sickle cell disease and other hereditary hemolytic anemias -- Transfusion therapy -- Anticoagulants, antiplatelet agents, and fibrinolytics -- Emergency complications of malignancy -- Headache and facial pain -- Stroke, transient ischemic attack, and subarachnoid hemorrhage -- Altered mental status and coma -- Ataxia and gait disturbances -- Vertigo and dizziness -- Seizures and status epilepticus in adults -- Acute peripheral neurological lesions -- Chronic neurologic disorders -- Central nervous system and spinal infections -- Ocular emergeinces -- Face and jaw emergencies -- Oral and dental emergencies -- Neck and upper airway disorders -- Dermatologic emergencies -- Other dermatologic disorders -- Trauma in adults -- Trauma in children -- Trauma in the elderly -- Trauma in pregnancy -- Head trauma in adults and children -- Spine and spinal cord injuries in adults and children -- Facial injuries -- Trauma to the neck -- Cardiothoracic trauma -- Abdominal injuries -- Penetrating trauma to the flank and buttocks -- Genitourinary injuries -- Penetrating trauma to the extremities -- Initial evaluation and management of orthopedic injuries -- Hand and wrist injuries -- Forearm and elbow injuries -- Shoulder and humerus injuries -- Pelvis, hip, and femur injuries -- Knee and leg injuries -- Ankle and foot injuries -- Compartment syndromes -- Neck and thoracolumbar pain -- Shoulder pain -- Hip and knee pain -- Acute disorders of the joint and bursae -- Emergencies in systemic rheumatic diseases -- Infectious and noninfectious disorders of the hand -- Soft tissue problems of the foot -- Clinical features of behavioral disorders -- Emergency assessment and stabilization of behavioral disorders -- Panic and conversion disorders -- Child and elderly abuse -- Sexual assault and intimate partner violence and abuse.
  • pt. 1: Upper gastrointestinal tract procedures -- pt. 2: Colorectal procedures -- pt. 3: Inguinal hernia and retroperitoneal procedures -- pt. 4: Procedures for pelvic floor disorders.
  • Endocrine surgery is a highly specialised field due to the technical nature of the procedures and associated risks. Despite this, endocrine operations sometimes fall to the general surgeon to deploy. Tips and Tricks in Endocrine Surgery aims to provide a concise summary of all aspects of endocrine surgery, taking into account the latest evidence and current expert opinion. The book comprises five sections covering the major endocrine organs and systems, each chapter focuses on one endocrine disorder and provides guidelines on the techniques, considerations and aspects of surgical care specific to each procedure. This book is an invaluable quick-reference resource that will appeal to higher surgical trainees in general surgery, endocrine surgery, ENT surgery and neurosurgery. Core surgical trainees preparing for examinations and consultants wishing to refresh their knowledge of the surgical management of endocrine disorders will also find this book useful.
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  • Biomolecular engineering in oligonucleotide applications -- Gene therapy -- Bio-nanorobotics: state of the art and future challenges -- sect. IV. Bionanotechnology. DNA as a scaffold for nano-structure assembly -- Directed evolution of proteins for device applications -- Semiconductor quantum dots for molecular and cellular imaging -- Bionanotechnology for bioanalysis -- Nano-hydroxyapatite for biomedical applications -- Nanotechnology provides new tools for biomedical optics -- Nanomaterials perspectives and possibilities in nanomedicine -- Biomedical nanoengineering for nanomedicine -- Physiogenomics: integrating systems engineering and nanotechnology for personalized medicine -- Bionanotechnology patenting: challenges and opportunities -- sect. V. Tissue engineering. Fundamentals of stem cell tissue engineering -- Growth factors and morphogens: signals for tissue engineering -- Extracellular matrix: structure, function, and applications to tissue engineering -- Esophagus: a tissue engineering challenge -- Tissue engineered vascular grafts -- Cardiac tissue engineering: matching native architecture and function to develop safe and efficient therapy -- Tissue engineering of heart valves -- Tissue engineering, stem cells and cloning for the regeneration of urologic organs -- Hepatic tissue engineering for adjunct and temporary liver support -- Tissue engineering of renal replacement therapy -- The bioengineering of dental tissues -- Tracheal tissue engineering -- sect. VI. Prostheses and artificial organs. Artificial heart and circulatory assist devices -- Cardiac valve prostheses -- Vascular grafts -- Artificial lungs and blood-gas exchange devices -- Artificial kidney -- Peritoneal dialysis equipment -- Therapeutic apheresis and blood fractionation -- Liver support systems -- Artificial pancreas -- Nerve guidance channels -- Tracheal, laryngeal, and esophageal replacement devices -- Artificial blood -- Artificial skin and dermal equivalents -- sect. VII. Ethics. Beneficence, nonmaleficence, and medical technology -- Ethical isseus related to clinical research. Mechanical forces on cells -- Cell adhesion -- Cell migration -- Inflammatory and immune responses to tissue engineered devices -- Polymeric scaffolds for tissue engineering applications -- Calcium phosphate ceramics for bone tissue engineering -- Biomimetic materials -- Nanocomposite scaffolds for tissue engineering -- Roles of thermodynamic state and molecular mobility in biopreservation -- Drug delivery -- Gene therapy -- Tissue engineering bioreactors -- Animal models for evaluation of tissue-engineered orthopedic implants -- The regulation of engineered tissues: emerging approaches -- Bioengineering of human skin substitutes -- Nerve regeneration: tissue engineering strategies -- Gene therapy and tissue engineering based on muscle-derived stem cells: potential for musculoskeletal tissue regeneration and repair -- Tissue engineering applications - bone -- Cartilage tissue engineering -- Tissue engineering of the tempormandibular joint -- Engineering smoot muscle -- Sect. I. Molecular biology. Historical perspective and basics of molecular biology -- Systems and technology involving bacteria -- Recombinant DNA technology using mammalian cells -- sect. II. Transport phenomena and biomimetic systems. Biomimetic systems -- Diffusional processes and engineering design -- Microvascular heat transfer -- Perfusion effects and hydrodynamics -- Animal surrogate systems -- Arterial wall mass transport: the possible role of blood phase resistance in the localization of arterial disease -- Control of the microenvironment -- Interstitial transport in the brain: principles for local drug delivery -- sect. III. Biotechnology. Tools for genome analysis -- Vaccine production -- Protein ngineering -- Metabolic engineering -- Monoclonal antibodies and their engineered fragments --
  • "This book bridges the gap between nanotechnology and regenerative medicine to facilitate their transition from lab to the clinic. It compiles important aspects of the basic science and fundamental principles to current nanotechnological innovations in biomaterials, cell, tissue, and organ engineering, and their clinical relevance, as well as future trends in regenerative medicine. It is intended for a wide audience including students, researchers, professors, and industrial experts working in the tields of biomaterial science and engineering, nanoscience and nanotechnology, bioengineering, cell biology, biomedical sciences, tissue engineering, and nanomedicine"--Provided by publisher.
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    Ch. 1. Tissue Engineering: A Historical Perspective / James D. Kretlow and Antonios G. Mikos -- Ch. 2. Current Clinical Needs in Hand Surgery / L. Scott Levin -- Ch. 3. Principles of Tissue Engineering for Reconstruction of the Hand / Ryosuke Kakinoki -- Ch. 4. Primary Cell Lines and Stem Cells / Katie L. Pricola and Hermann Peter Lorenz -- Ch. 5. Scaffolds / Wei Liu and Yilin Cao -- Ch. 6. Animal Models for Engineering Tissues in the Upper Extremity / Xing Zhao and Mark A. Randolph -- Ch. 7. Guidance Strategies in Hand Tissue Engineering: Manipulating the Microenvironment Through Cellular and Material Cues / Harvey Chim and Arun K. Gosain -- Ch. 8. Bioreactors / Laurence A. Galea and Wayne A. Morrison -- Ch. 9. Nerve Engineering / Gregory H. Borschel -- Ch. 10. Tendon Engineering / Johan Thorfinn, Ioannis Angelidis, Brian Pridgen and James Chang -- Ch. 11. Skin / Deepak M. Gupta, Nicholas J. Panetta, Geoffrey C. Gurtner and Michael T. Longaker -- Ch. 12. Bone and Cartilage / Ashley Rothenberg and Jennifer Elisseeff -- Ch. 13. Blood Vessels / Masayuki Yamato and Teruo Okano -- Ch. 14. Bench to Bedside: Navigating Industry, the FDA and Venture Capital / Nicholas J. Panetta, Deepak M. Gupta, Michael T. Longaker and Geoffrey C. Gurtner.
  • BASICS AND PRINCIPLES: Scaffolds: Micro and Nano Technology -- Biomimetic Materials -- Natural and Synthetic Scaffolds: Adhesion, ECM, Structure, Function, Modification -- Cells: Sources, Growth, Differentiation, Trans-Differentiation -- Embryonic Stem Cells: Sources and Characterization -- Adult Stem Cells: Sources and Characterization -- Isolation and Growth -- Differentiation and Plasticity -- Regulation Mechanisms: Key Signaling Molecules -- Cell and Organ preservation -- Engineering Technologies: Animal Models for Evaluation of Tissue Engineering Constructs -- Biomedical Imaging and Image Processing -- Bioreactors for Tissue Engineering -- Drug delivery -- Gene Therapy -- OROGANS: Liver -- Musculoskeletal Tissues -- Lung -- CNS -- Peripheral Nervous System -- Nephrons -- Biohybrid organs -- Heart and Cardiovascular Engineering -- Eye/Retina -- Respiratory Systems Engineering -- Ear -- Skin -- TISSUE TYPES: Adipose Tissue -- Blood Substitutes -- Angiogenesis and Vascularization -- Bone Tissue -- Brain Tissues -- Cartilage Tissue -- Pancreatic Tissues -- Tendons -- Tissue Engineering in Reproductive Medicine, of Heart Valves, in Oral and Maxillofacial Surgery -- Uro-Gital System/Bladder Tissue.
  • pt. 1. Stem cells -- pt. 2. Biomaterials and the extracellular environment -- pt. 3. Engineered tissue -- pt. 4. Synthetic organs -- pt. 5. Immune response -- pt. 6. Animal models.
  • pt. 1. General issues -- pt. 2. Tissue and organ generation.
  • Tissue engineering. 2nd ed. 2007
    Springer Protocols
    In vitro expansion of tissue cells by conditional proliferation -- Stem cell engineering using transducible Cre recombinase -- Human embryonic stem cells for tissue engineering -- Culture and characterization of human bone marrow mesenchymal stem cells -- Skeletal ("Mesenchymal") stem cells for tissue engineering -- Biomaterials/Scaffolds -- Synthetic hydrogel matrices for guided bladder tissue regeneration -- Generation of multicellular tumor spheroids by the hanging-drop method -- In vitro vascularization of human connective microtissues -- Artificial skin -- Small blood vessel engineering -- Artificial pancreas to treat type 1 Diabetes Mellitus -- Human articular chondrocytes culture -- Cardiomyocytes from human and mouse embryonic stem cells -- Myocardial restoration and tissue engineering of heart structures -- Practical aspects of cardiac tissue engineering with electrical stimulation -- Biological scaffolds for heart valve tissue engineering -- In vitro heart valve tissue engineering.
  • Applications of tissue microarray technology -- Quality aspects of TMA analysis -- Representativity of TMA studies -- Recipient block TMA technique -- Protocol for constructing tissue arrays by cutting edge matrix assembly -- Hypodermic needle without recipient paraffin block technique -- Resin technologies : construction and staining of resin TMA's -- Tissue microarrays from frozen tissues-OCT technique -- An alternative technology to prepare tissue microarray using frozen tissue samples -- Building "tissue" microarrays from suspension cells -- Tissue microarrays from biopsy specimens -- Immunohistochemical analysis of tissue microarrays -- DNA copy number analysis on formalin-fixed paraffin-embedded tissues in TMA format by RNA in situ hybridization -- Automated analysis of tissue microarrays -- Digital microscopy for boosting database integration and analysis in TMA studies -- From gene to clinic : TMA-based clinical validation of molecular markers in prostate cancer
  • Capabilities using 2-D DIGE in proteomics research : the new gold standard for 2-D gel electrophoresis / Christine R. Rozanas and Stacey M. Loyland -- Protein carbohydrate analysis : gel-based staining, liquid chromatography, mass spectrometry, and microarray screening / Injae Shin, Alina D. Zamfir, and Bin Ye -- Surface-enhanced laser desorption/ionization mass spectrometry for protein and peptide profiling of body fluids / Audrey Gagnon, Qian Shi, and Bin Ye -- A novel approach using MALDI-TOF mass spectrometry and prestructured sample supports (AnchorChip technology) for proteomic profiling and protein identification / Sau-Mei Leung and Rebecca L. Pitts -- Automated laser capture microdissection for tissue proteomics / Adrianna S. Rodriguez ... [et al.] -- Tissue microarrays : an overview / Rajiv Dhir -- Frozen protein arrays / Stephen M. Hewitt and Robert A. Star -- Reverse phase protein microarrays for theranostics and patient-tailored therapy / Virginia Espina ... [et al.] -- Antibody arrays for determination of relative protein abundances / Grigoriy S. Chaga -- SH2 domain-based tyrosine phosphorylation array / Xin Jiang ... [et al.] -- Immunoregulomics : a serum autoantibody-based platform for transcription factor profiling / Oliver W. Tassinari ... [et al.] -- The "reverse capture" autoantibody microarray : an innovative approach to profiling the autoantibody response to tissue-derived native antigens / Joshua R. Ehrlich ... [et al.] -- Biorepository standards and protocols for collecting, processing, and storing human tissues / Dean Troyer.
  • 1. Cytomechanics in connective tissue repair and engineering / Robert A. Brown -- 2. Scleroderma lung fibroblasts : contractility and connective tissue growth factor / Galina S. Bogatkevich ... [et al.] -- 3. Functional assessment of fibroblast heterogeneity by the cell-surface glycoprotein thy-1 / Carolyn J. Baglole ... [et al.] -- 4. Tissue repair in asthma : the origin of airway subepithelial fibroblasts and myofibroblasts / Sabrina Mattoli -- 5. Experimental models to study the origin and role of myofibroblasts in renal fibrosis / Michael Zeisberg, Mary A. Soubasakos and Raghu Kalluri -- 6. Epithelial to mesenchymal transition of mesothelial cells as a mechanism responsible for peritoneal membrane failure in peritoneal dialysis patients / Abelardo Aguilera ... [et al.] -- 7. FIZZy alveolar epithelial cells induce myofibroblast differentiation / Sem H. Phan -- 8. Pro-invasive molecular cross-signaling between cancer cells and myofibroblasts / Olivier De Wever and Marc Mareel -- 9. Proangiogenic implications of hepatic stellate cell transdifferentiation into myofibroblasts induced by tumor microenvironment / Elvira Olaso ... [et al.] -- 10. Matrix metalloproteinases, tissue inhibitors of metalloproteinase and matrix turnover and the fate of hepatic stellate cells / Aqeel M. Jamil and John P. Iredale -- 11. Innate immune regulation of lung injury and repair / Dianhua Jiang ... [et al.] -- 12. An Eye on repair : myofibroblasts in corneal wounds / James V. Jester.
  • Tissue surgery 2006
  • TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems.
  • Phylogeny of the TRAF/math domain / Juan M. Zapata, Vanesa Martínez-García, and Sophie Lefebvre -- TRAF1 and its biological functions / Soo Young Lee and Yongwon Choi -- Physiological roles and mechanisms of signaling by TRAF2 and TRAF5 / Ping-Yee Billie Au and Wen-Chen Yeh -- TRAF3 and its biological function / Jeannie Q. He ... [et al.] -- TRAF4, the unique family member / Valérie Kedinger and Marie-Christine Rio -- Characteristics and biological functions of TRAF6 / Jun-ichiro Inoue, Jin Gohda and Taishin Akiyama -- Ubiquitination and TRAF signaling / Gabriel Pineda, Chee-Kwee Ea and Zhijian J. Chen -- Structural revelations of TRAF2 function in TNF receptor signaling pathway / Jee Y. Chung ... [et al.] -- Protein-protein interactions in TRAF3 / Kathryn R. Ely, Ramadurgam Kodandapani and ShuangDing Wu -- Molecular basis for the unique specificity of TRAF6 / Jee Y. Chung ... [et al.] -- TRAF proteins in CD40 signaling / Gail A. Bishop ... [et al.] -- TRAFs in rank signaling / Bryant G. Darnay ... [et al.] -- The LT[beta]R signaling pathway / Paula S. Norris and Carl F. Ware -- LMP1 trafficking activates growth and survival pathways / Vishal Soni, Ellen Cahir-McFarland and Elliott Kieff -- Targeting TRAFs for therapeutic intervention / Juan M. Zapata, Sophie Lefebvre and John C. Reed.
  • The gradual increase in longevity in the United States and elsewhere has already brought about a slow-motion revolution in nearly every sector of society, from health care to housing to employment. But if radical life extension moves from the realm of fantasy to reality, that revolution will pick up considerable speed. Extending human life spans beyond those of even the oldest of our ancestors would raise a host of new social, political, economic, environmental, moral and other questions. Religious organizations have traditionally played an important role in helping people think through end-of-life matters and respond to significant social changes. But since life extension has not made the journey from fantasy to fact, there has been little official or even quasi-official guidance in this area from churches and other religious groups.
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    Pioneer women doctors campaign for wartime service -- From pioneer women doctors abroad to "joining the home team" -- From contract surgeon to Army medical officer -- Enter the women neuropsychiatrists/psychiatrists -- "Specialization as a mark of expertise": women doctors in internal medicine, pathology, anesthesiology, and orthopedics -- "Narrowing the field": women doctors in radiology, preventive medicine, surgery, and other areas -- More than they expected: nonspecialists and other problems in service -- "I do not regret having had the opportunity to serve my country": a look back at women's experiences as medical officers in the United States Army -- Appendix.
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    "Here are highlights from Paul Farmers' speeches to a variety of audiences, from Princeton to Harvard to Notre Dame to Berkeley. Paul is a rock star of the academy who has a large following among many groups: students, doctors, general readers, activists, public health folks, professors. He is the pied piper of everyone who wants to change the world. Not only is he cofounder of Partners In Health,US Deputy Special Envoy to Haiti, head of social medicine at Harvard, but he's also a charming, humorous, engaging public speaker whose charisma is legend. In this book, conceived of as a graduation gift for students write large, Farmer addresses the challenges facing young people with a call for them to change the world and become activists."-- [Provided by publisher]
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  • History of tobacco production and use / Hanafin, J., Clancy, l. -- Global tobacco epidemic / Mackay, J., Schluger, N. -- The tobacco epidemic and the commercial sector : tobacco industry strategies to increase profits and prevent regulation / Weishaar, H. -- Chemistry and primary toxicity of tobacco and tobacco smoke / Wiebel, F.J. -- Nicotine dependence / Zaveri, N., Rollema, H., Swan, G.E. -- The psychology of the smoker / Gilbert, D.G., Pergadia, M.L. -- Respiratory disorders related to smoking tobacco / Murray, J.F., Buist, A.S. -- Cardiovascular and other (except respiratory) disorders related to smoking tobacco / Barnoya, J., Monzon, J.C. -- Health effects of passive smoking in children / Bush, A. -- Health effects of passive smoking in adults / Kabir, Z., Clancy, L. -- Economics of tobacco use and control / Townsend, J. -- Legislation and smoking prevention / Latif, E., Warner, V. -- The WHO framework convention on tobacco control / Poetschke-Langer, M., Schotte, K., Zilagyi, T. -- Youth and tobacco / Bauer, C., Kreuter, M. -- Impact of media, movies and TV on tobacco use in the youth / Sargent, J.D., Hanewinkel, R. -- Social determinants of cigarette smoking / Upson, D. -- Smoking and mental health problems / Caill-Garnier, S., Baker, A.L, Todd, J., Turner, A., Dayas, C. -- Patterns and predictors of smoking cessation / Ditre, J.W., Zale, E.L., Brandon, T.H. -- Examining the role of the health care professional in controlling the tobacco epidemic : individual, organizational and institutional responsibilities / Leone, F.T., Evers-Casey, S. -- Pharmacotherapy : nicotine replacement therapy and other drugs in smoking cessation (including vaccination) / Tonnesen, P. -- Smokeless tobacco : health hazards or less harm? / Bolinder, G., Gilljam, H. (stockholm) -- Waterpipe tobacco smoking : a less harmful alternative? / Jawad, M. -- Electronic cigarettes : the issues behind the moral quandary / Vardavas, C.I., Agaku, I.T.
  • Tobacco science, policy, and public health. 2nd ed. 2010
    OSO, Limited to 3 simultaneous users
    "Comprehensively covers the science and policy issues relevant to one of the major public health disasters of modern times. It pulls together the etiology and burden of the myriad of tobacco-related diseases with the successes and failures of tobacco control policies. The book looks at lessons learnt to help set health policy for reducing the burden of tobacco-related diseases. It also deals with the international public health policy issues which bear on control of the problem of tobacco use and which vary between continents."--Publisher's description
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    Trends in tobacco use -- Financial burden of tobacco use: an employer's perspective -- The impact of tobacco use and secondhand smoke on hospitality workers -- Tobacco and law enforcement officers -- Tobacco and the health care industry -- Tobacco and the movie industry -- Current tobacco control policy trends in the United States -- Current trends in international tobacco control -- Tobacco and carcinogens in the workplace -- Respiratory health consequences of environmental tobacco smoke -- Pulmonary and cardiovascular consequences of smoking -- Smoking and systemic disease -- Tobacco and HIV.
  • "A New Avenue of Research Beyond Traditional Studies of Vitamin E. The first 90 years of vitamin E research has produced prolific and notable discoveries. Until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Tocotrienol discovery came much later, in 1965, but existed for almost 20 years as an obscure vitamin E. Explores Treatment Possibilities: Tocotrienols have proven to contain some exceptional benefits that aren't shared by the better known tocopherols. Although both are antioxidants, today a bright spot for tocotrienol research is in cancer and heart disease, while emergent fields of tocotrienol research are on the rise with many covered in this edition. Currently, tocotrienols have reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years was published in the last 3 years. The thriving field of tocotrienol research gives ground for publication of this 2nd edition, a compilation of the latest tocotrienol research in all new chapters. For the past 10 years, Professors Ronald R. Watson and Victor R. Preedy have published books on bioactive nutrients and dietary supplements. Professor Watson has been and is currently funded to do research by grants from the American Heart Foundation and the U.S. National Institute of Heart, Lung, and Blood. By gathering the contributions contained in this volume, they have expanded the field of knowledge and forged a new path in disease treatment and prevention"--Provided by publisher.
  • Evolved from online and live-in-person lectures presented in bacteriology courses at the University of Wisconsin-Madison. New material is constantly being added, and current material is constantly being revised and updated.--Website
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    At the age of 20, a young man tells his story of his diagnosis of testicular cancer, and shares the pains and struggles he endured while undergoing intense chemotherapy and radiation treatments due to his late-stage diagnosis. A true testimony of the importance of talking about the disease in our society, and what happens if testicular cancer gets overlooked for too long. Ian's story stresses that catching the disease when it is in early stages is essential to avoid intense treatments and increase the chance of survival. It is a warning to all young men to be proactive in their own testicular health and learn about testicular cancer, the most common and curable cancer in young men, in order to avoid the fate that Ian suffered. The final chapter includes medical image explaining testicular cancer metastasis, facts about the disease, its symptoms, and how to perform a testicular self-examination.
  • Introduction: toll receptors and the renaissance of innate immunity / Elizabeth H. Bassett and Tina Rich -- The function of toll-like receptors / Zlatko Dembic -- Structures and motifs involved in toll signaling / Monique Gangloff, Phumzile L. Ludidi and Nicholas J. Gay -- "Supramolecular" activation clusters in innate immunity / Martha Triantafilou and Kathy Triantafilou -- Interleukin-I receptor/toll-like receptor signaling / Harald Wajant, Peter Scheurich and Frank Henkler -- Virus induced signaling to initiate the interferon mediated anti-viral host response / Claudia Wietek and Luke A.J. O'Neill -- The induction of dendritic cell activation and maturation by toll-like receptor signaling / Tsuneyasu Kaisho and Shizuo Akira -- Pathogen avoidance using toll signaling in C. elegans / Nathalie Pujol and Jonathan J. Ewbank -- Forward genetic analysis of TLR pathways: a shared system for the detection of endotoxin and viral infection / Bruce Beutler ... [et al.] -- Agonists of toll-like receptor 9: modulation of host immune responses with synthetic oligodeoxynucleotides / Ekambar R. Kandimalla and Sudhir Agrawal.
  • Overview of toll-like receptors in the CNS / Tammy Kielian -- Toll-like receptors in bacterial meningitis / Uwe Koedel -- Toll-like receptors in brain abscess / Nilufer Esen and Tammy Kielian -- Toll-like receptors in CNS viral infections / Hyeon-Sook Suh, Celia F. Brosnan and Sunhee C. Lee -- Toll-like receptors in CNS parasitic infections / Bibhuti B. Mishra, Uma Mahesh Gundra and Judy M. Teale -- Toll-like receptors in neurodegeneration / Trevor Owens -- Toll-like receptors in spinal cord injury / Kristina A. Kigerl and Phillip G. Popovich -- Toll-like receptors in Alzheimer's disease / Gary E. Landreth and Erin G. Reed-Geaghan -- Toll-like receptors in multiple sclerosis / Michael K. Racke and Phil D. Drew -- Toll-like receptors in peripheral nerve injury and neuropathic pain / Donghoon Kim, Soojin Lee and Sung Joong Lee.
  • Tomosynthesis imaging 2014
    "Preface For much of the past century, projection radiography has been the workhorse in the diagnostic imaging clinic. Tomosynthesis, which introduces depth information to the x-ray radiographic image with little or no increase in radiation dose, could potentially replace projection radiography as we move into the twenty-first century. This book, Tomosynthesis Imaging, offers the most comprehensive resource to date for this new emerging imaging technology. Digital tomosynthesis imaging is a novel quasi-three dimensional x-ray imaging modality that has been primarily developed during the past two decades, owing to the availability of large-area digital x-ray detectors. The tomosynthesis image is reconstructed from a sequence of projection images that are acquired from a limited angle x-ray scan, therefore, conceptually, tomosynthesis might be considered as limited-angle CT. Because of the limited angle acquisition, resolution in the reconstructed volume is not isotropic. The resolution in image planes parallel to the detector surface is similar to the native detector resolution, but the resolution perpendicular to the detector surface direction is substantially worse, and depends on the scan arc length and on the size of the detail being imaged. Tomosynthesis imaging is being actively investigated for use in a variety of clinical tasks. Currently, tomosynthesis breast imaging is at the forefront, having received approval for clinical use in Europe and Canada in 2008, and FDA approval in the United States in 2011. Although conventional mammography has been very successful in reducing the breast cancer mortality rate, its sensitivity and specificity are less then desirable, especially for women with dense breast tissue"--Provided by publisher.
  • Toothpastes 2013
    An introduction to toothpaste : its purpose, history, and ingredients / Lippert, F. -- Fluorides and non-fluoride remineralization systems / Amaechi, B.T., van Loveren, C. -- Antiplaque and antigingivitis toothpastes / Sanz, M., Serrano, J.; Iniesta, M.; Santa Cruz, I., Herrera, D. -- The role of toothpastes in oral malodor management / Dadamio, J., Laleman, I., Quirynen, M. -- Anti-calculus and whitening toothpastes / van Loveren, C., Duckworth, R.M. -- The role of toothpaste in the aetiology and treatment of dentine hypersensitivity / Addy, M., West, N.X. -- Toothpaste and erosion / Ganss, C., Schulze, K., Schlueter, N. -- Abrasivity testing of dentifrices : challenges and current state of the art / González-Cabezas C., Hara, A., Hefferren, J., Lippert, F. -- Laboratory and human studies to estimate anticaries efficacy of fluoride toothpastes / Tenuta, L.M.A., Cury, J.A. -- Pharmacokinetics in the oral cavity : fluoride and other active ingredients / Duckworth, R.M. -- After-brush rinsing protocols, frequency of toothpaste use : fluoride and other active ingredients / Parnell, C., O'Mullane, D.
  • Congenital and developmental -- Attenuation and signal abnormality -- Masses and masslike lesions -- Vasculature and cerebrospinal fluid spaces -- Calvarium and skull base -- Temporal bone -- Sinonasal -- Maxillofacial -- Neck (including spaces) -- Orbits.
  • Chest and cardiac imaging -- Gastrointestinal imaging -- Genitourinary imaging -- Musculoskeletal imaging -- Head and neck imaging -- Brain and spine imaging -- Pediatric imaging -- Ultrasound imaging -- Fetal imaging -- Vascular and interventional radiology -- Nuclear medicine -- Breast imaging -- Roentgen classics.
  • Expert urologists give their personal insight into the best methods of overcoming a variety of scenarios that occur during urologic surgery, randing from how to best salvage specific difficult intra-operative problems, to simplifying complex procedures, or tips advising on how best to clarify diagnosis.
  • Mucosal membranes have unique anatomical and physiological properties -- differing from those of the keratinized epithelium -- which affect drug or chemical absorption. This makes the diagnosis and treatment of diseases of the mucosa a challenge to dermatologists as well as gynecologists, since many conditions are difficult to recognize and well-established principles of skin disease treatment do not apply to the mucosa. This volume is exclusively devoted to the mucosal membrane and delivers a better understanding of this distinctive area. Subsequently to introductory chapters on the morphology and physiology of the mucosa, the topical treatment of impaired mucosal membranes is discussed. A third section covers the wide spectrum of consumer products applied on mucosal surfaces. Finally, the safety of products for mucosal membranes is reviewed. Providing an excellent summary and review of the latest findings and topical applications, this book will be of great value to physicians and clinicians in dermatology or gynecology, pharmacists, scientists and toxicologists who are involved in the development of products for mucosal membranes.
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  • Topics in bone biology v. 2-, 2005-
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    Bd. 1. Allgemeines, Brust und Brustgliedmasse -- Bd. 2. Bauch, Becken und Beckengliedmasse.
  • Total burn care. 4th ed. 2012
    2012 ClinicalKey
    A brief history of acute burn care management -- Teamwork for total burn care: Burn centers and multidisciplinary burn teams -- Epidemiological, demographic, and outcome characteristics of burn injury -- Prevention of burn injuries -- Burn management in disasters and humanitarian crises -- Care of outpatient burns -- Pre-hospital management, transportation and emergency care -- Pathophysiology of burn shock and burn edema -- Fluid resuscitation and early management -- Evaluation of the burn wound: Management decisions -- Enzymatic debridement of burn wounds -- Treatment of infection in burns -- Operative wound management -- Anesthesia for burned patients -- The skin bank -- Alternative wound coverings -- The role of alternative wound substitutes in major burn wounds and burn scar resurfacing -- The pathophysiology of inhalation injury -- Diagnosis and treatment of inhalation injury -- Respiratory care -- The systemic inflammatory response syndrome -- The immunological response and strategies for intervention -- Hematologic and hematopoietic response to burn injury -- Significance of the adrenal and sympathetic response to burn injury -- The hepatic response to thermal injury -- Effects of burn Injury on bone and mineral metabolism -- Vitamin and trace element homeostasis following severe burn injury -- Hypophosphatemia -- Nutritional support of the burned patient -- Modulation of the hypermetabolic response after burn injury -- Etiology and prevention of multisystem organ failure -- Renal failure in association with thermal injuries -- Critical care in the severely burned: Organ support and management of complications -- Burn nursing -- Special considerations of age: The pediatric burned patient -- Care of geriatric patients -- Surgical management of complications of burn injury -- Electrical injuries -- Electrical injury: Reconstructive problems -- Cold-induced injury: Frostbite -- Chemical burns -- Radiation injuries and vesicant burns -- Exfoliative diseases of the integument and soft tissue necrotizing infections -- The burn problem: A pathologist's perspective -- Molecular and cellular basis of hypertrophic scarring -- Pathophysiology of the burn scar -- Comprehensive rehabilitation of the burn patient -- Musculoskeletal changes secondary to thermal burns -- Mitigation of burn-induced hypermetabolic and catabolic response during convalescence -- Reconstruction of burn deformities: An overview -- The use of skin grafts, skin flaps and tissue expansion in burn deformity reconstruction -- Microvascular technique of composite tissue transfer -- Reconstruction of the head and neck -- Correction of burn alopecia -- Reconstruction of the burned breast -- Management of contractural deformities involving the shoulder (axilla), elbow, hip and knee joints in burned patients -- Care of a burned hand and reconstruction of the deformities -- Management of burn injuries of the perineum -- Reconstruction of burn deformities of the lower extremity -- The ethical dimension of burn care -- Intentional burn injuries -- Functional sequelae and disability assessment -- Cost-containment and outcome measures -- Management of pain and other discomforts in burned patients -- Psychiatric disorders associated with burn injury -- Psychosocial recovery and reintegration of patients with burn injuries.
  • Part I: Ceramic-on-Ceramic Articulations -- Technology and Handling of Ceramic Implants -- Long-Term Stability of Ceramic Composite in Total Hip Arthroplasty -- Ceramic-Ceramic Bearing in Difficult Hips (Primary and Revision) -- Alumina-on-Alumina Bearings in Hip Arthroplasty: What Every Surgeon Should Know -- Part II: Metal-on-Metal Articulations -- Metal-on-Metal Resurfacing and the Cost to the Nation: A Conservative Estimate of the Unexpected Costs Required to Implement the New Metal-on-Metal Follow-Up Programme in the UK -- A Clinicopathological Study of Metal-on-Metal Hips Revised for Suspected Adverse Reactions to Metal Debris -- Metal-on-Metal Bearings and Surgical Techniques in Active Patients with Severe Hip Deformity -- The Incidence of Pseudotumour in Metal-on-Metal Hip Resurfacing and the Results of a Screening Tool for Patient Recall -- Part III: Polyethylene - Standard and New Improvements -- New Polys and Large Heads: Clinical Aspects -- The Influence of Head Material on Polyethylene Wear -- Basic Science and Longtime Results of Different Polyethylene Articulations -- Part IV: Large Diameter Heads -- Head Size and Metal-on-Metal Bearings -- Aseptic Loosening of Metal-on-Metal (MOM) Total Hip Arthroplasties (THA) with Large-Diameter Heads -- Large Head Articulations: Benefits and Drawbacks -- Can the Increased Loosening Rate of the Modular-Neck Hip Systems Be Attributed to Geometric Design Parameters? An Alternative Approach Using Finite Element Analysis -- Fracture of the Titanium Neck in a Modular Femoral Component -- Part V: Clinical Aspects -- Wear of Hard-on-Hard Bearings in the Hip: The Influence of Loss of Conformity Under Edge Loading -- Considerations for the Use of Bearing Partners in Total Hip Arthroplasty -- Total Hip Arthroplasty Using a Short, Metaphyseal-Fitting Anatomic Cementless Femoral Component in Patients with Femoral Head Osteonecrosis Who Are Less than 30 Years Old -- Survival of Monoblock Acetabular Cups Versus an Uncemented Modular Cup Design: A Population-Based Study from the Swedish Hip Arthroplasty Register.
  • Introduction: Tribology of hip prostheses -- wear performance and reliability -- effect of materials and head size -- How to treat failures related to articulation. Polyethylene articulations: Oxidation prevention with vitamin E in a HXLPE isoelastic monoblock pressfit cup -- Preliminary results -- In-Vitro Wear Testing of Conventional vs. Sequentially Cross-Linked Polyethylene Liners in Combination with Different Ceramic Femoral Heads -- Characterization of Vitamin E-blended UHMWPE for higher in vivo performance in orthopaedic arthroplasty -- Long-term reduction of wear and osteolysis with crosslinked PE? 13-years follow-up of a prospectively randomized comparison with conventional PE. Metal articulations: Metal-on-metal bearings in hip surgery: The London Implant Retrieval Centre Experience -- Total Hip Arthroplasty with a large diameter metal-on-metal cup (Durom) and a standard stem -- Short term results -- Polyethylene wear in metal-backed cups -- A retrospective analysis of 200 uncemented metal-backed cups. Immunological adverse reaction associated with low carbide content metal-on-metal bearings in a contemporary cementless total hip arthroplasty. Ceramic articulations: Fracture and squeaking in ceramic-on-ceramic bearings -- is it really a concern?- Long term stability of ceramic composite in total hip arthroplasty -- Ceramic-on-ceramic bearings in hip arthroplasty: a clinical review. Miscellaneous: Study of a titanium dual mobility socket with a mean follow-up of 18 years -- ECIMATM for low wear, good mechanical properties and oxidation resistance of hip bearings.
  • This book offers a comprehensive guide to total knee arthroplasty (TKA) that will assist in achieving excellent outcomes based on a sound understanding and technique. After an introductory section on the native knee that covers the anatomy, physiology, biomechanics, and patterns of disease, all aspects of primary knee arthroplasty are discussed in detail. Individual chapters are devoted to topics such as acute pain management, the role of technological aids, prosthetic kinematics, alignment targets, unicompartmental arthroplasty, patellar resurfacing, outcome measures, and cost-effectiveness. An extensive section explains the causes and management of potential complications, including aseptic failure, infections, and periprosthetic fracture. The surgical techniques appropriate for revision knee arthroplasty are described separately, and guidelines on how to deal with bone loss, instability, and extensor mechanism failure are provided. The authors are all respected experts from the United Kingdom, United States, Australia and Europe.
  • 1. A brief history of total knee arthroplasty -- 2. Kinematics of the natural and replaced knee -- 3. Long term survival of total knee arthroplasty. Lessons learned from the clinical outcome of old designs -- 4. Long term survival of total knee arthroplasty. Lessons learned from the clinical outcome of old designs. Second generation of implants and the total condylar TKA -- 5. Total knee arthroplasty. Evaluating outcomes -- 6. The long term outcome of total knee arthroplasty. The effect of age and diagnosis -- 7. Long term outcome of primary total knee arthroplasty. The effect of body weight and level of activity -- 8. Long term clinical outcome of total knee arthroplasty. The effect of the severity of deformity -- 9. Long term clinical outcome of total knee arthroplasty. The effect of surgeon training and experience -- 10. Long term clinical outcome of total knee arthroplasty. The effect of limp alignment, implant placement and stability as controlled by surgical technique -- 11. Long term results of total knee arthroplasty. The effect of surgical approach -- 12. Long term clinical outcome of total knee arthroplasty. The effect of posterior stabilized designs -- 13. Long term clinical outcome of total knee arthroplasty. The effect posterior cruciate retaining design -- 14. Rationale and long term outcome to rotating platform total knee replacement -- 15. Mid to long term clinical outcome of medial pivot designs -- 16. Long term clinical outcome of total knee arthroplasty. The effect of implant fixation (cementless) -- 17. Long term clinical outcome of total knee arthroplasty: the effect of polyethylene -- 18. Long term clinical outcome of total knee arthroplasty. Condylar constrained prostheses -- 19. Long term clinical outcome of total knee arthroplasty rotating hinge designs -- 20. Clinical outcome of total knee megaprosthesis replacement for bone tumors -- 21. Long term clinical outcome of total knee arthroplasty. The effect of patella resurfacing -- 22. Infected total knee arthroplasty. Basic science, mangement, and outcome -- 23. Short and mid term outcome of total knee arthroplasty. The effect of rahabilitation -- 24. Mid and long term functional outcome of total knee arthroplasty -- 25. Long term outcome of total knee arthroplasty. The effect of navigation -- 26. Quality of life and patient satisfaction after total knee arthroplasty using contemporary designs -- Index.
  • Posterior cruciate ligament retention versus substitution -- Mobile versus fixed bearings in total knee arthroplasty -- Primary total knee arthroplasty surgical technique -- Total knee arthroplasty in severe varus deformity -- Total knee arthroplasty in severe valgus deformity -- Patellofemoral complications associated with total knee arthroplasty -- Stiffness before and after total knee arthroplasty -- Flexion contracture associated with total knee arthroplasty -- Total knee arthroplasty after osteotomy -- Total knee arthroplasty in rheumatoid arthritis -- Bone stock deficiency in total knee arthroplasty -- Bilateral simultaneous total knee arthroplasty -- Sepsis and total knee arthroplasty -- Staying out and getting out of trouble during total knee arthroplasty -- Repeat operation after total knee arthroplasty -- Unicompartmental knee arthroplasty -- Unicompartmental knee arthroplasty technique -- Frequently asked questions concerning total knee arthroplasty.
  • Total knee replacement 2009
    Unicompartmental Knee Arthroplasty -- Posterior Cruciate Ligament-Retaining Total Knee Arthroplasty -- Posterior-Stabilized Technique -- Methods of Rotational Alignment in Primary Total Knee Arthroplasty -- Valgus Total Knee Replacement -- Total Knee Replacement in the Varus Knee -- Tibial Component Alignment in Total Knee Arthroplasty: Intramedullary, Extramedullary, and Computer-Assisted Techniques -- Quadriceps-Sparing Total Knee Arthroplasty -- Minimally Invasive Total Knee Arthroplasty with Limited Medial Parapatellar Arthrotomy -- Minimally Invasive Subvastus Approach for Total Knee Arthroplasty -- Minimal Incision Total Knee Arthroplasty: the Mini-Midvastus Approach -- Monoblock Total Knee Arthroplasty -- Cementless Fixation -- Cemented Total Knee Arthroplasty -- Principles of Revision Total Knee Replacement -- Preoperative Planning for Revision Total Knee Replacement -- Surgical Exposures for Revision Total Knee Arthroplasty -- Soft Tissue Balancing in Revision Total Knee Arthroplasty -- Removing Well-Fixed Implants -- Revision of Failed Unicompartmental Knee Arthroplasty -- Cemented Stem Fixation in Revision Total Knee Arthroplasty -- Uncemented Stems in Revision Total Knee Arthroplasty -- PROSTALAC Articulating Spacer for Infected Total Knee Replacements -- Impaction Bone Grafting for Defects in Revision Total Knee Arthroplasty -- Treatment of Periprosthetic Femoral Fractures above a Total Knee Arthroplasty -- Knee Arthrodesis with an Intramedullary Nail After Failed Total Knee Arthroplasty -- Flexion and Extension Gap Balancing in Revision Total Knee Arthroplasty -- Extensor Mechanism Reconstruction in Total Knee Arthroplasty -- Metal Augments -- Metaphyseal Porous Metal Cones -- Structural Allografting -- Porous Tantalum for Patellar Reconstruction in Revision Total Knee Arthroplasty -- Cancellous Patellar Bone Grafting in Revision Total Knee Arthroplasty -- Hinged Total Knee Arthroplasty.
  • Assesses the current state of the science regarding primary and revision total knee replacements. References appear in 5 broad categories that parallel topics presented at the conference, with many of the topics further broken down. Citations may appear in only one category.
  • Preface -- 1 Position of the patient -- 2 Steps shared by Total and Subtotal Gastrectomy -- 3 Total Gastrectomy -- 4 Manual Subtotal Gastrectomy.- 5 Stapled Subtotal Gastrectomy -- 6 Proximal Gastrectomy -- 7 Total and Subtotal D2 Laparoscopic Gastrectomy.- 8 Lymphadenectomy -- 9 Special Cases.
  • Part I. In the Beginning: Generating, Detecting, and Manipulating the MR (NMR) Signal -- Laying the Foundation: Nuclear Magnetism, Spin, and the NMR Phenomenon -- Rocking the Boat: Resonance, Excitation, and Relaxation -- Relaxation: What Happens Next? -- Image Contrast: T1, T2, T2*, and Proton Density -- Hardware, Especially Gradient Magnetic Fields -- Part II. User Friendly: Localizing and Optimizing the MRI Signal for Imaging -- Spatial Localization: Creating an Image -- Defining Image Size and Spatial Resolution -- Putting It All Together: An Introduction to Pulse Sequences -- Understanding, Assessing, and Maximizing Image Quality -- Artifacts: When Things Go Wrong, It's Not Necessarily All Bad -- Safety: First, Do No Harm -- Part III. To the Limit: Advanced MRI Applications -- Preparatory Modules: Saturation Techniques -- Readout Modules: Fast Imaging -- Volumetric Imaging: The Three-dimensional Fourier Transform -- Parallel Imaging: Acceleration with SENSE and SMASH -- Flow and Angiography: Artifacts and Imaging of Coherent Motion -- Diffusion: Detection of Microscopic Motion -- Understanding and Exploiting Magnetic Susceptibility -- Spectroscopy and Spectroscopic Imaging: In Vivo Chemical Assays by Exploiting the Chemical Shift.
  • Since their first application in 1982, Totally Implantable Venous Access Devices (TIVADs) have become increasingly important in the clinical practice, as more intensive chemotherapy and parenteral treatments have come into use. At this time, there is objective evidence that TIVADs are a safe, effective strategy for long-term venous access; they play a significant role throughout the management of the oncology patient, as they are needed in the initial phases for active treatments as well as in the last stages for palliative measures, making possible repeated administration of chemotherapeutic vesicant agents, nutrients, antibiotics, analgesics, and blood products. According to a number of prospective studies, use of TIVADs is associated with a significant complication rate (10% to 25% of all patients). Evidence-based data support that most complications are directly related to inappropriate technique of placement and/or nursing care, sometimes leading to TIVAD loss, significant morbidity, increased duration of hospitalization, and additional medical cost. A group of world-renowned experts - both in the clinical and research fields - contributed to this volume, whose aim is to provide clinicians, nurses and medical students with a multidisciplinary, full update on these devices, as long term central venous access can no be longer considered a routine matter, and serious complications can be maintained at a very low level only if strict adherence to a well-defined protocol of surgical technique and of catheter care is maintained.
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    Zur Entwicklung des nationalen Habitus in Deutschland -- Veränderungen des Verhaltens-, Gefühls- und Denkstandards von Ärzten -- Geschichte der Medizin anhand einiger ausgewählter Schwerpunkte -- Der unpolitische Arzt? -- Die satisfaktionsfähige Gesellschaft -- Militärmedizin im Ersten Weltkrieg -- Schubkraft von Kriegen -- Zur Geschichte der deutschen Psychiatrie -- Von der Entstehung der Eugenik als Wissenschaft zur Diskussion und Durchführung der Tötungen von Menschen -- Die Theorie Darwins und die Entwicklung sozial-darwinistischer Vorstellungen -- Auswirkungen der Darwinschen Theorie -- Vom Sozialdarwinismus zur Rassenhygiene -- Zur Entwicklung eugenischer Konzepte in Deutschland -- Ärzte helfen Hitler und der nationalsozialistischen Bewegung -- Die Freikorps : Wegbereiter Hitlers -- Vom heilenden zum tötenden Arzt : die Auflösung des Gewissens -- Die Ausschaltung jüdischer Ärzte -- Zwangssterilisationen -- Tötungen von Kindern -- Erwachsenentötungen -- Ärzte übernehmen direktes medizinisches Töten -- Selektion an der Rampe : Ärzte im Konzentrationslager -- Ärztliche Tätigkeiten in Konzentrationslagern -- Menschenversuche : Ärzte experimentieren am "Objekt Mensch -- Unterdruck- und Unterkühlungsversuche -- Versuche mit Fleckfieber-Impfstoff -- Hepatits Epidemica-Virus-Forschung -- Sulfonamid-, Knochentransplantations- und Phlegmonversuche -- Zwillingsforschung : das Kaiser Wilhelm-Institut für Anthropologie, menschliche Erblehre und Eugenik in Berlin Dahlem und das Konzentrationslager Auschwitz -- Der Prozess und die Urteile von Nürnberg -- Exkurs : nach 1945 -- Schlussbetrachtung -- Literaturverzeichnis.
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    Introduction -- The road to the mandate -- Appropriate constitutional limits -- Bad news for mail robbers -- What the court did -- Where it hurts.
  • "Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward precision medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward precision medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy."--Publisher's description.
  • Scientific medicine in Miettinen's conception of it is very different from the two ideas about it that came to eminence in the 20th century. To him, medicine is scientific to the extent that it has a rational theoretical framework and a knowledge-base from medical science. He delineates the nature of that theoretical framework and of the research to develop the requisite knowledge for application in such a framework. The knowledge ultimately needed is about diagnostic, etiognostic, and prognostic probabilities, and it necessarily is to be codified in the form of probability functions, embedded in practice-guiding expert systems.
  • A rigorous and groundbreaking study. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. The author tackles a subject that has puzzled care professionals for decades: hypochondria. Martine Derzelle confronts all specialists (psychotherapists, psychiatrists, doctors, psychosomaticians) with the paradox of this pathology and the theoretical void on which the approach to those patients who express a suffering of various kinds has stood for more than a century. In the first part, the author highlights the lack of theoretical elaboration on hypochondria in the existent literature; in the second part, on the basis of clinical examples, she analyzes the nature of the disease, and then offers a completely innovative theoretical elaboration. Finally, in the third part, she proposes a new and specific approach to treating this pathology at both the theoretical and clinical levels within the framework of psychoanalysis and implementing key concepts from relational psychosomatics.
  • The book explains how to understand cognition in terms of brain anatomy, physiology and chemistry, using an approach adapted from techniques for understanding complex electronic systems. These techniques create hierarchies of information process based descriptions on different levels of detail, where higher levels contain less information and can therefore describe complete cognitive phenomena, but are more approximate. The nature of the approximations are well understood, and more approximate higher level descriptions can therefore be mapped to more precise detailed descriptions of any part of a phenomenon as required. Cognitive phenomena, the anatomy and connectivity of major brain structures, neuron physiology, and cellular chemistry are reviewed. Various cognitive tasks are described in terms of information processes performed by different major anatomical structures. These higher level descriptions are selectively mapped to more detailed physiological and chemical levels.--[Source inconnue].
  • Part I. Perspectives on Thinking -- Problem Solving / Michael Öllinger and Vinod Goel -- Heuristic Bias, Conflict, and Rationality in Decision-Making / Wim De Neys -- Analogical Processes in Human Thinking and Learning / Dedre Gentner and Julie Colhoun -- A Gestalt Perspective on the Psychology of Thinking / Michael Wertheimer -- Thought and Reality: A Philosophical Conjecture About Some Fundamental Features of Human Thinking / Albrecht von Müller -- Part II. Components of Thinking -- Categorization and Object Shape / Markus Graf -- Comparison / Robert L. Goldstone, Sam Day, and Ji Y. Son -- Causal Thinking / Michael R. Waldmann -- Conditionals: Their Meaning and Their Use in Reasoning / Klaus Oberauer -- Thinking and Memory / Matthias Brand and Hans J. Markowitsch -- Perception and the Brain / Nikos Logothetis -- Part III. Onto- and Phylogenetic Considerations -- A Developmental Perspective on Modularity / Annette Karmiloff-Smith -- Theory of Mind / Beate Sodian and Susanne Kristen -- The Development of Metacognitive Competences / Wolfgang Schneider -- Understanding Apes to Understand Humans: The Case of Object-Object Relations / Josep Call -- Part IV. Language, Emotion, Culture -- Socializing Cognition / Anne Böckler, Günther Knoblich, and Natalie Sebanz -- Thinking and Language: A View from Cognitive Semio-Linguistics / Per Aage Brandt -- Thinking and Emotion: Affective Modulation of Cognitive Processing Modes / Annette Bolte and Thomas Goschke -- Cultural Differences in Thinking Styles / Shihui Han -- Part V. Modeling and Neurobiological Aspects -- Natural Selection in the Brain / Chrisantha Fernando and Eörs Szathmáry -- Value and Self-Referential Control: Necessary Ingredients for the Autonomous Development of Flexible Intelligence / Olaf Sporns and Edgar Körner -- Cortical Connectivity: The Infrastructure of Thoughts / Giorgio M. Innocenti -- Models as Tools to Aid Thinking / Helge Ritter.
  • This book takes a bold stand: all psychology should be culturally sensitive psychology, especially when studying religious phenomena. It explains that culture is not simply to be conceived of as a variable that possibly influences behavior. Rather, it stresses that cultural patterns of acting, thinking and experiencing are created, adopted and promulgated by a number of individuals jointly. As human subjectivity is different in different cultures, cultural psychology is not interested in comparatively investigating how experiences and behavior, attitudes and social relationships present themselves within different cultural conditions. By consequence, cultural psychology does not start from Western psychological constructs, testing for their presence in other cultures, but from human acts and activities in specific cultures, analyzing them in a hermeneutical way. Like cultural psychology, psychology of religion currently enjoys more and more interest and rapid growth. But the two fields have remained rather unconnected in the recent past. Psychological research on religion has been pursued from a number of perspectives, among which a cultural psychological one has not yet become prominent. As religions, however conceptualized, are cultural entities of major importance, cultural psychology seems a natural ally to research on religion. Containing a number of studies, both theoretical and empirical, this volume takes a step towards a rapprochement of cultural psychology and psychology of religion.
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    Foreword / Lois Gibbs -- Preface : Toxic exposures and the challenge of environmental health -- Acknowledgments -- List of abbreviations -- 1. Citizen-science alliances and health social movements : contested illnesses and challenges to the dominant epidemiological paradigm -- 2. Breast cancer : a powerful movement and a struggle for science -- 3. Asthma, environmental factors, and environmental justice -- 4. Gulf War-related illnesses and the hunt for causation : the "stress of war" versus the "dirty battlefield" -- 5. Similarities and differences among asthma, breast cancer, and Gulf War illnesses -- 6. The new precautionary approach : a public paradigm in progress -- 7. Implications of the contested illnesses perspective -- 8. Conclusion : the growing environmental health movement -- Notes -- Bibliography -- Index.
  • Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
  • Overview of drug development / James A. Popp and Jeffery A. Engelhardt -- Nonclinical safety evaluation of drugs / Thomas M. Monticello and Jeanine L. Bussiere -- Toxicokinetics and drug metabolism : relating toxicity to compound exposure and disposition / David D. Christ -- Introduction to toxicologic pathology / Judit E. Markovits ... [et al.] -- Routine and special techniques in toxicologic pathology / Daniel J. Patrick, Peter C. Mann -- Principles of clinical pathology / Robert L. Hall -- Toxicogenomics in toxicologic pathology / Mark J. Hoenerhoff and David E. Malarkey -- Spontaneous lesions in control animals used in toxicity studies / Robert C. Johnson, Robert H. Spaet, Daniel L. Potenta -- Gastrointestinal tract / Judit E. Markovits -- Liver, gall bladder, and exocrine pancreas / Russell C. Cattley, James A. Popp, Steven L. Vonderfecht -- Respiratory system / David J. Lewis and Tom P. McKevitt -- Urinary system / Kendall S. Frazier and John Curtis Seely -- Hematopoietic system / Kristin Henson, Glenn Elliott, Gregory S. Travlos -- The lymphoid system / Patrick J. Haley -- Bone, muscle, and tooth / John L. Vahle ... [et al.] -- The cardiovascular system / Calvert Louden, David Brott -- Endocrine glands / Sundeep Chandra, Mark Hoenerhoff, Richard Peterson -- Reproductive system and mammary gland / Justin D. Vidal ... [et al.] -- Skin / Zbigniew Wojcinski ... [et al.] -- Nervous system / Mark T. Butt, Robert Sills, Alys Bradley -- Special senses : eye and ear / James A. Render, Kenneth A. Schafer, Richard A. Altschuler.
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  • International and federal bodies involved in risk assessment of chemical substances -- Data for hazard assessment -- Hazard assessment -- Standard setting : threshold effects -- Standard setting : non-threshold effects (carcinogenicity) -- Exposure assessment -- Risk characterization -- Regulatory standards set by various bodies -- Combined actions of chemicals in mixture.
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  • "The widespread and increasing use of carbon nanotubes in scientific and engineering research and their incorporation into manufactured goods has urged an assessment of the risks and hazards associated with exposure to them. The field of nanotoxicology studies the toxicology of nanoparticles such as carbon nanotubes and has become a major growth area aimed towards risk assessment of nanoparticles. Compiled by a team of leading experts at the forefront of research, this is the first book dedicated to the toxicology of carbon nanotubes. It provides state-of-the-science information on how and why they are so potentially dangerous if breathed in, including their similarities to asbestos. The book examines various aspects of carbon nanotubes, from their manufacture and aerodynamic behaviour to their effects at molecular level in the lungs. It is invaluable to the many groups involved with research in this area, as well as to regulators and risk assessors"-- Provided by publisher.
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  • Introduction: the gastrointestinal (GI) tract as a barrier and as an absorptive and metabolic organ / Shayne C. Gad -- Methods for the analysis of gastrointestinal function / Robin C. Guy -- Safety pharmacology and the GI tract / Henry I. Jacoby -- Gastronintestinal tract development and its importance in toxicology / Joseph V. Rodricks, Allison A. Yates, and Claire L. Kruger -- The GI tract as major route of pharmaceutical administration / Robert W. Kapp, Jr. -- Gastrointestinal function and toxicology in canines / Charles Spainhour -- Absorption of macromolecules by mammalian intestinal epithelium / Shayne C. Gad -- Peyer's patch epithelium: an imperfect barrier / Gary R. Burleson and Florence G. Burleson -- Alteration of intestinal function by xenobiotic exposure: animal models / Shayne C. Gad -- Intestinal absorption and metabolism of xenobiotics in laboratory animals / William J. Brock -- Normal and abnormal intestinal absorption by humans / David W. Hobson and Valerie L. Hobson -- Intestinal absorption and metabolism of xenobiotics in humans / William J. Brock and David W. Hobson.
  • Toxicology of the skin 2010
    Pt. 1. Skin morphology and barrier properties -- pt. 2. Altered barriers -- pt. 3. Methods of delivery -- pt. 4. Skin toxicity.
  • Structured account of the existing knowledge of toxic algae, the chemistry of the toxins they produce, the effects these substances exert in humans and wildlife, as well as the strategies envisaged to protect public health and the environment. Covers recent advances in the understanding of the biology of toxin producers and the factors involved in the appearance and dynamics of harmful algae blooms, the factors affecting toxin production, the synthesis of toxins both in natural producers and by chemical means in a lab, and the toxin groups posing continuing and novel. Studies effects toxic microalgae and their poisonous products exert on living systems and how they may affect human activities.
  • "Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents."
  • Toxins in food 2005
  • This book reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism.
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    Tomo I. 1904-1914 -- Tomo II. 1915-1923 -- Tomo III. 1923-1930 -- Tomo IV. 1931-1936 -- Tomo V. 1937-1946 -- Tomo VII. 1954-1957 -- Tomo VIII. 1960-1965 -- Tomo IX. 1965-1967.
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    The history of tracheotomy and intubation / Steven M. Zeitels ... [et al.] -- Alternatives to tracheostomy / Andrew Herlich -- Technique and complications of tracheostomy in adults / Rohan R. Walvekar and Eugene N. Myers -- Technique and complications of tracheostomy in the pediatric age group / Robert F. Yellon -- Tracheostomy in the intensive care unit setting / K. Kost -- Selecting a tracheostomy tube: current options / Carl-Eric Lindholm -- Tracheostomy in burn patients / H. Slater -- Tracheostomy in patients with the obstructive sleep apnea syndrome / Jonas T. Johnson -- Nursing management of the patient with a tracheostomy / Marilyn Hudak and Margaret Hickey -- Long-term care of patients with a tracheostomy / David A. Nace and Andrea R. Fox -- Communication options for tracheostomy and ventilator-dependent patients / Marta S. Kazandjian and Karen J. Dikeman -- Management of swallowing disorders in the patient with a tracheostomy / R.L. Carrau and T. Wasserman-Wincko.
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    In health care, geography is destiny -- The Vermont experience -- Tonsillectomy and medical opinion -- Interpreting the pattern of surgical variation -- Understanding the market for preference-sensitive surgery -- Learning what works and what patients want -- The birth and near death of comparative effectiveness research -- Understanding supply-sensitive care -- Chronic illness and practice variation -- Is more better? -- Are America's "best hospitals" really the best? -- Ten top reasons why we need to reform the way we manage chronic illness -- Promoting organized care and reducing overuse -- Establishing shared decision making and informed patient choice -- Six ways to control costs, and accelerate health care reform -- The challenge of practice variations.
  • The traditional and scientific bases for traditional Chinese medicine : communication between traditional practitioners, physicians and scientists / James D. Adams, Jr. and Eric J. Lien -- Structure-activity relationship analysis of plant-derived compounds / Eric J. Lien, Linda L. Lien and James D. Adams -- Huang Di Nei Jing and the treatment of low back pain / Minchen Wang (Vince) -- Understanding ch'i : the life-force energy that determines vitality, health and wellbeing / Marcia R. Babcock -- When modern computational systems biology meets traditional Chinese medicine / Calvin Yu-Chian Chen -- Modern drug discovery from Chinese materia medica used in traditional Chinese medicine / Kuo-Hsiung Lee, Susan L. Morris-Natschke, Joshua Brattlie, Jingxi Xie and Eileen Belding -- PI3K-AKT signaling in cell growth and metabolism / Yang Li, Anketse Kassa and Bangyan L. Stiles -- The scientific evidence for using astragalus in human diseases / William C.S. Cho -- Traditional Chinese medicine : anti-inflammation for cancer prevention / Constance L. L. Saw, Chee L. Saw and Lita S.T. Chew -- Treatment of stroke with Dan Shen, Salvia miltiorrhiza / James David Adams, Jr. -- Drug discovery from traditional Chinese medicine for neurogenesis : implications for stroke and neurodegenerative diseases / Jiangang Shen and Xingmiao Chen -- Medicinal uses of seaweed in traditional Chinese medicine / Eri Oshima -- The preventive effect of traditional Chinese medicinal herbs on type 2 Diabetes mellitus / Zhijun Wang, Patrick Chan and Jeffrey Wang -- Translational approach to treating diabetes using acupuncture or electroacupuncture / Philip V. Peplow and G. David Baxter.
  • 1. Learning environment and setting up a training unit in Minimal Access Surgery -- 2. Training curriculum in Minimal Access Surgery -- 3. Simulation and Training in Minimal Access Surgery -- 4. Training basic laparoscopic skills -- 5. Training for trainers in Endoscopy (colonoscopy) -- 6. Teaching advanced laparoscopic skills in colorectal surgery -- 7. Teaching advanced laparoscopic skills in surgery for morbid obesity -- 8. Teaching advanced laparoscopic skills in urological surgery -- 9. Training for new thechniques and robotic surgery in Minimal Access Surgery -- 10. Teletraining in Minimal Access Surgery -- 11. Assessment and Acreditation in Minimal Access Surgery -- 12. Training the trainer in laparoscopic surgery -- 13. The Human Factor in Minimal Access Surgical Training: How conscientious, well trained Surgeons make mistakes.
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    t. 1. Ostéologie. Arthrologie. Myologie -- t. 2. Angéilogie. Système nerveux central -- t. 3. Système nerveux périphérique. Organes des sens -- t. 4. Appareil de la digestion. Appareil de la respiration et de la phonation. Appareil uro-génital. Embryologie.
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  • Scientific Foundation for Global Computing / Robin Milner -- Interdisciplinary Innovation in International Initiatives / John C. Wooley -- A Grand Challenge for Converging Sciences / Ronan Sleep -- Applying Computer Science Research to Biodiversity Informatics: Some Experiences and Lessons / Andrew C. Jones -- e-Science and the VL-e Approach / L.O. (Bob) Hertzberger -- From Syntax to Semantics in Systems Biology Towards Automated Reasoning Tools / François Fages -- SYMBIONIC: A European Initiative on the Systems Biology of the Neuronal Cell / Ivan Arisi, Paola Roncaglia, Vittorio Rosato, Antonino Cattaneo -- A Biological Approach to Autonomic Communication Systems / Iacopo Carreras, Imrich Chlamtac, Francesco De Pellegrini, Csaba Kiraly, Daniele Miorandi, Hagen Woesner -- The Twilight of the Despotic Digital Civilization / Michel Riguidel -- A Compositional Approach to the Stochastic Dynamics of Gene Networks / Ralf Blossey, Luca Cardelli, Andrew Phillips -- A Weighted Profile Based Method for Protein-RNA Interacting Residue Prediction / Euna Jeong, Satoru Miyano.
  • Use of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors' experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea, and esophagus, and miscellaneous items including the role of robotic surgery.
  • Electroconvulsive therapy : update and new research / Eser, D. ... [et al.] -- Repetitive transcranial magnetic stimulation effects in vitro and in animal models / Keck, M.E. -- Neuroimaging of repetitive transcranial magnetic stimulation effects on the brain / George, M.S. ... [et al.] -- Efficacy and safety of prefrontal repetitive transcranial magnetic stimulation in affective disorders / Padberg, F. ... [et al.] -- Repetitive transcranial magnetic stimulation in augmentation of antidepressant drugs / Ortega Rumi, D.O. ... [et al.] -- Transcranial magnetic stimulation versus electroconvulsive therapy for the treatment of more severe major depression / Janicak, P.G. ... [et al.] -- Transcranial magnetic stimulation in schizophrenia / Odebrecht Rosa, M. ... [et al.] -- Repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder and other anxiety disorders / Pridmore, S., Marcolin, M.A., Mansur, C.G. -- Repetitive transcranial magnetic stimulation in non-psychiatric disorders : pain, Parkinson's disease, stroke, tinnitus / Lefaucheur, J.-P, Khedr, E.M. -- Induction and modulation of neuroplasticity by transcranial direct current stimulation / Nitsche, M.A. ... [et al.] -- Magnetic seizure therapy for the treatment of depression / Lisanby, S.H., Peterchev, A. -- Theta burst stimulation / Huang, Y.-Z., Rothwell, J.C. -- Transcranial magnetic stimulation of deep brain regions : principles and methods / Roth, Y., Padberg, F., Zangen, A.
  • A review of post-translational modifications and subcellular localization of Ets transcription factors : possible connection with cancer and involvement in the hypoxic response / Céline Charlot ... [et al.] -- Regulation of transcription factor function by targeted protein degradation : an overview focusing on p53, c-Myc, and c-Jun / Jukka Westermarck -- Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents / Aldo Giudice, Claudio Arra, and Maria C. Turco -- Subnuclear localization and intranuclear trafficking of transcription factors / Sayyed K. Zaidi ... [et al.] -- Analysis of ligand-dependent nuclear accumulation of Smads in TGF-[beta] signaling / Douglas A. Chapnick and Xuedong Liu -- Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1 / Richard Y.M. Ma ... [et al.] -- Coupling of dephosphorylation and nuclear export of Smads in TGF-[beta] signaling / Fangyan Dai ... [et al.] -- Assessing sequence-specific DNA binding and transcriptional activity of STAT1 transcription factor / Thomas Meyer and Uwe Vinkemeier -- Analysis of nuclear export using photoactivatable GFP fusion proteins and interspecies heterokaryons / Kerry-Ann Nakrieko, Iordanka A. Ivanova, and Lina Dagnino -- Determination of nuclear localization signal sequences for Krüppel-like factor 8 / Tina S. Mehta, Farah Monzur, and Jihe Zhao -- Methods to measure nuclear export of [beta]-catenin using fixed and live cell assays / Manisha Sharma and Beric R. Henderson -- Imaging of transcription factor trafficking in living cells : lessons from corticosteroid receptor dynamics / Mayumi Nishi -- Hypoxia-inducible factors : post-translational crosstalk of signaling pathways / Elitsa Y. Dimova and Thomas Kietzmann -- The basic helix-loop-helix-leucine zipper gene Mitf : analysis of alternative promoter choice and splicing / Kapil Bharti ... [et al.] -- Phosphorylation control of nuclear receptors / Sébastien Lalevée, Christine Ferry, and Cécile Rochette-Egly -- Regulation of Krüpple-like [i.e. Krüppel-like] factor 5 by targeted protein degradation / Ceshi Chen -- Post-translational control of ETS transcription factors : detection of modified factors at target gene promoters / Li Li, Janice Saxton, and Peter E. Shaw -- Integration of protein kinases into transcription complexes : identifying components of immobilised in vitro pre-initiation complexes / Hong-Mei Zhang ... [et al.] -- Post-translational modification of p53 by ubiquitin / Chunhong Yan -- Phosphorylation-dependent regulation of SATB1, the higher-order chromatin organizer and global gene regulator / Dimple Notani ... [et al.] -- In vivo and in vitro tools to identify and study transcriptional regulation of USF-1 target genes / Marie-Dominique Galibert and Sébastien Corre -- Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting / David C. Clarke and Xuedong Liu -- Flow cytometry analysis of transcription factors in T lymphocytes / Diana I. Albu, Danielle Califano, and Dorina Avram -- Identification of specific protein/E-box-containing DNA complexes : lessons from the ubiquitously expressed USF transcription factors of the b-HLH-LZ super family / Marie-Dominique Galibert and Yorann Baron.
  • 1. The Stem cell state / Gary R. Hime, Helen E. Abud -- 2. Induction of pluripotency / Corey Heffernan, Jun Liu, Huseyin Sumer -- pt. I. Model stem cell systems (A): invertebrate -- 3. Germline stem cells and their regulation in the nematode Caenorhabditis elegans / Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter -- 4.Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny / Helen White-Cooper, Simona Caporilli -- 5. Stem cells in the Drosophila digestive system / Xiankun Zeng, Chhavi Chauhan, Steven X. Hou -- 6. Mechanisms of asymmetric progenitor divisions in the Drosophila central nervous system / Rita Sousa-Nunes, W. Gregory Somers -- pt. II. Model stem cell systems (B): vertebrate -- 7. Transcriptional/translational regulation of mammalian spermatogenic stem cells / Cathryn A. Hogarth -- 8. Transcriptional regulation and specification of neural stem cells / Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate -- 9. Transcriptional control of epidermal stem cells / Briana Lee, Xing Dai -- 10. Regulation of intestinal stem cells by WNT and notch signalling / Katja Horvay, Helen E. Abud -- 11. Transcriptional regulation of haematopoietic stem cells / Adam C. Wilkinson, Berthold Göttgens -- 12. The Regulation of mesenchymal stem cell differentiation / David Cook, Paul Genever -- pt. III. Molecular families implicated in stem cell regulation -- 13. The Musashi family of RNA binding proteins: master regulators of multiple stem cell populations / Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime, Nicole A. Siddall -- 14. JAK-STAT signaling in stem cells / Rachel R. Stine, Erika L. Matunis -- 15. Myc in stem cell behaviour: insights from Drosophila / Leonie M. Quinn, Julie Secombe, Gary R. Hime -- 16. The Role of nuclear receptors in embryonic stem cells / Qin Wang, Austin J. Cooney -- 17. Epigenetic regulation of stem cells / Anton Wutz -- 18. Regulation of stem cell populations by microRNAs / Julie Mathieu, Hannele Ruohola-Baker -- 19. Myb and the regulation of stem cells in the intestine and brain: a tale of two niches / Jordane Malaterre, Lloyd Pereira, Robert G. Ramsay.
  • Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.
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  • "Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology. A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies, covers: Commercial development of devices and products based on transdermal physical enhancement technologies, Selecting optimal enhancement technology for a specific drug molecule using case studies that cover physicochemical properties as well as practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection, Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines, Practical information on experimental procedures and challenges related to skin irritation and safety issues. Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace"--Provided by publisher.
  • This book discusses in depth the transdisciplinary integration of different components of care in colorectal surgery. Pertinent background information on the complexities of current management in colorectal surgery is first provided, followed by discussion of the role of design thinking in care integration. Subsequent chapters focus on a range of issues associated with surgical and perioperative care in patients undergoing colorectal surgery, with emphasis on how the multiple facets of care can be integrated through a transdisciplinary approach. Each chapter provides helpful take-home messages in bullet point form and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, oncologists, nurses, and allied health professionals with extensive experience in the field.
  • ""This book makes a great leap in the conceptualization of transdisciplinary approaches, as well as provides concrete examples in practice, teaching, policy, and research."" -From the Foreword by Edward F. Lawlor, dean and the William E. Gordon Distinguished Professor, the Brown School; and founding director, Institute for Public Health at Washington University in St. Louis The complexity of public health and social problems is becoming more challenging. Understanding and designing solutions for these problems requires perspectives from multiple disciplines and fields as well
  • "Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
  • Transesophageal echocardiography (TEE) has played an instrumental role among the many advances in the field of congenital heart disease (CHD) that have resulted in successful and continually improving clinical outcomes, today enabling most affected infants and children to live well into adulthood. Ongoing evolution of the technology (including three-dimensional TEE) promises to maintain this imaging approach at the forefront of clinical practice. Competent performance of TEE in the patient with CHD, however, requires a number of essential technical and cognitive skills, in addition to a solid understanding of the broad spectrum of congenital pathology. Thus, the important need for a comprehensive reference on the subject to assist specialists who care for these patients. Transesophageal Echocardiography for Congenital Heart Disease represents a unique work, the only textbook of its kind that focuses specifically upon the applications of TEE in CHD. In each chapter, the contributorshighly regarded specialists and leaders in the fieldprovide practical and instructive information on the many different aspects of CHD evaluation by TEE. The textbook is extensively supplemented with over 700 figures/illustrations and more than 400 high quality videos (available online). This reference will prove an invaluable resource for those who use TEE in the care of both children and adults with CHD, whether they be cardiologists, surgeons, anesthesiologists, intensivists, sonographers, or trainees wishing to obtain basic knowledge or advance their understanding of the field.
  • Introduction -- The left ventricle -- The left atrium -- The mitral valve -- The aortic valve and aorta -- The right heart -- Artificial valves.
  • v. 2 2008 Springer
    v. 1. Basic and clinical biology -- v. 2. Cancer treatment and therapy.
  • "Health care organizations are challenged to improve care at the bedside for patients, learn from individual patients to improve population health, and reduce per capita costs. To achieve these aims, leaders are needed in all parts of the organization need positive solutions. Transforming Health Care Leadership provides healthcare leaders with the knowledge and tools to master the unprecedented level of change that health care organizations and their leaders now face. It also challenges management myths that served in bureaucracies but mislead in learning organizations"--Provided by publisher.
  • Back breaking work: implementing a spine registry in an orthopedic clinic / Brian C. Crolet -- A RHIO struggling to form: will it get off the ground? / Paul Zlotnik, Denny Lee, Mike Minear, and Prashila Dullabh -- A rough ride at the Theodore Roosevelt Cancer Center / Karen Albert, Nitika Gupta, Teresa Mason, Purvi Mehta -- Implementation of an electronic prescription writer in ambulatory care / Minhui Xie and Keven B. Johnson -- Online health care: a classic clash of technology, people and processes / John Butler, Dan Dalan, Brian McCourt, John Norris, and Randall Stewart -- A dungeon of dangerous practices / Andrew Amata, Allen Flynn, Michelle Morgan, Teresa Smith, and Mary Tengdin -- Different sides of the story / Allison B. McCoy -- Barcode medication administration implementation in the FIAT Health System / Linda Chan, William Greeley, Don Klingen, Brian Machado, Michael Padula, John Sum, and Angela Vacca -- H.I.T. or Miss / James McCormack, Bimal R. Desai, Jennifer Garvin, Randal Hamric, Kirk Lalwani, Andi Lushag, Alexey Panchenko, Deborah Quitmeyer, and JoAnna M. Vanderhoef -- The implementation of secure messaging / Zhou Yan -- Who moved my clinic? Donnelly University Pediatric Rehabilitation : the wheelchair clinic / Fredrick Hilliard -- OncoOrders: The early years / Chris Raggio and Judith W. Dexheimer -- Implementing a computerized triage system in the emergency department / Scott R. Levin, Daniel J. France, and Dominik Aronsky -- Medication barcode scanning: Code "Moo": dead COW / Laurie L. Novak and Kathy S. Moss -- Project NEED: new efficiency in an emergency department / Barry Little, Denise Johnson, Jennifer Tingle, Mary Stanfill, and Michael Roy. -- Digital radiology divide at McKinly / Neal Goldstein, David Ross, Ken Christensen, Jayashree Kalpathy-Cramer, Aseem Kumar, and Marilyn Schroeder.
  • In the last decade, there have been several clinical trials that have studied red blood cell transfusion triggers in various Intensive Care Unit patient populations. Moreover, critically ill patients often suffer from coagulopathy. Recent studies have addressed the effectiveness of fresh frozen plasma and platelets to prevent or treat bleeding. This book offers a comprehensive summary of transfusion triggers for red blood cells in specific ICU patient populations and specific conditions with the aim to personalize transfusion strategy. In addition, it discusses evidence for triggers for plasma and platelets and outlines the most common adverse effects of blood transfusion in the ICU, underlining the need for a careful assessment of its risks and benefits. Transfusion in the Intensive Care Unit is a practical handbook that can be used in everyday practice to guide transfusion and thus will serve as a valuable resource for physicians, fellows and residents working in Intensive Care, Anesthesiology, and Cardiac Surgery.
  • The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issuesEasy to use, with focused, well-defined chapters in a standardized format throughoutOffers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities.
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    Perspectives on the state of insect transgenics / David A. O'Brochta and Alfred M. Handler -- Alphavirus transducing systems / Brian D. Foy and Ken E. Olson -- Paratransgenesis applied for control of tsetse transmitted sleeping sickness / Serap Aksoy, Brian Weiss, and Geoffrey Attardo -- Bacteria of the genus Asaia: a potential paratransgenic weapon against malaria / Guido Favia ... [et al.] -- Proposed uses of transposons in insect and medical biotechnology / Peter W. Atkinson -- The yin and yang of linkage disequilibrium: mapping of genes and nucleotides -- Conferring insecticide resistance in insect disease vectors / William C. Black IV ... [et al.] -- Impact of technological improvements on traditional control strategies / Mark Q. Benedict and Alan S. Robinson -- Insect population suppression using engineered insects / Luke Alphey ... [et al.] -- Wolbachia-based technologies for insect pest population control / Kostas Bourtzis -- Using predictive models to optimize wolbachia-based strategies for vector-borne disease control / Jason L. Rasgon -- Modifying insect population age structure to control vector-borne disease / Peter E. Cook, Conor J. McMeniman, and Scott L. O'Neill -- Technological advances to enhance agricultural pest management / Thomas A. Miller, Carol R. Lauzon, and David J. Lampe -- Applications of mosquito ecology for successful insect transgenesis-based disease prevention programs / Thomas W. Scott ... [et al.].
  • Transgenic and knockout models of psychiatric disorders: introduction, history, and assessment / Gene S. Fisch -- Transgenic mouse models and human psychiatric disease / Jonathan Flint -- Transgenic and knockout mouse models: the problem of language / Linda J. Hayes and Diana Delgado -- If only they could talk: genetic mouse models for psychiatric disorders / Trevor Humby and Lawrence Wilkinson -- Spinocerebellar ataxia type 1: lessons from modeling a movement disease in mice / Harry T. Orr -- Mouse models of hereditary mental retardation / Hans Welzl ... [et al.] -- How can studies of animals help to uncover the roles of genes implicated in human speech and language disorders? / Simon E. Fisher -- Animal models of autism: proposed behavioral paradigms and biological studies / Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon -- Genetic mouse models of psychiatric disorders: advantages, limitations, and challenges / Joseph A. Gogos and Maria Karayiorgou -- Animal models of psychosis / Stephen I. Deutsch ... [et al.] -- Animal models of anxiety: the ethological perspective / Robert Gerlai, Robert Blanchard, and Caroline Blanchard -- Modeling human anxiety and depression in mutant mice / Andrew Holmes and John F. Cryan -- Mutant mouse models of bipolar disorder: are there any? / Anneloes Dirks, Lucianne Groenink, and Berend Olivier.
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    In the grip of algal genomics / Arthur R. Grossman -- Insertional mutagenesis as a tool to study genes/functions in chlamydomonas / Aurora Gaván, David González-Ballester, and Emilio Fernández -- Optimization of recombinant protein expression in the chloroplasts of green algae / Samuel P. Fletcher, Machiko Muto, and Stephen P. Mayfield -- Nuclear transformation of eukaryotic microalgae : historical overview, achievements, and problems / Rosa León and Emilio Fernández -- Transformation of cyanobacteria / Agustín Vioque -- Molecular biology and the biotechnological potential of diatoms / Peter Kroth -- Tools and techniques for chloroplast transformation of chlamydomonas / Saul Purton -- Phycoremediation of heavy metals using transgenic microalgae / Sathish Rajamani ... [et al.] -- Hydrogen fuel production by transgenic microalgae / Anastasios Melis, Michael Seibert, and Maria L. Ghirardi -- Microalgal vaccines / Surasak Siripornadulsil, Konrad Dabrowski, and Richard Sayre.
  • Introduction: strategies for developing genetically modified mice / Marten H. Hofker -- Genetic modification of the mouse: general technology - pronuclear and blastocyst injection / Jan Willem Voncken -- Generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos / Jérôme Artus and Anna-Katerina Hadjantonakis -- Cryopreservation of mouse spermatozoa and in vitro fertilization / Naomi Nakagata -- Autopsy and histological analysis of the transgenic mouse / Marion J.J. Gijbels and Menno P.J. de Winther -- Transgene design / Bart van de Sluis and Jan Willem Voncken -- Inducible transgenic mouse models / Thomas L. Saunders -- Lentiviral transgenesis / Terunaga Nakagawa and Casper C. Hoogenraad -- Transgenesis in mouse embryonic stem cells / Janine van Ree, Wei Zhou, Ming Li, and Jan M. van Deursen -- Engineering BAC reporter gene constructs for mouse transgenesis / Yu Fu and Peter Maye -- Targeting vector construction through recombineering / Liviu A. Malureanu -- Generating conditional knockout mice / Roland H. Friedel, Wolfgang Wurst, Benedikt Wefers, and Ralf Kühm -- Hypomorphic mice / Darren J. Baker -- MICER targeting vectors for manipulating the mouse genome / Chunbong Liu, Paul F. Szurek, and Y. Eugene Yu -- Knock-in approaches / Anton J.M. Roebroek, Philip L.S.M. Gordts, and Sara Reekmans -- Generation of a series of knock-in alleles using RMCE in ES cells / Anton J.M. Roebroek, Philip L.S.M. Gordts, and Sara Reekmans -- Selection of targeting mutants from a library of randomly mutagenized ES cells / Kyoji Horie, George Gaitanaris, and Alexander Gragerov -- Generation of genetically modified rodents using random ENU mutagenesis / Ruben van Boxtel and Edwin Cuppen -- Bone marrow transplantations of study gene function in hematopoietic cells / Menno P.J. de Winther and Peter Heeringa -- Adenovirus-mediated gene transfer / Ko Willems van Dijk, Kyriakos E. Kyreos, Frits J. Fallaux, and Jurre Hageman.
  • Transgenic wheat, barley and oats : production and characterization / Paul A. Lazzeri and Huw D. Jones -- Selection of transformed plants / Huw D. Jones and Caroline A. Sparks -- Reporter genes / Alison Huttly -- Biolistics transformation of wheat / Caroline A. Sparks and Huw D. Jones -- Agrobacterium-mediated transformation of bread and durum wheat using freshly isolated immature embryos / Huixia Wu, Angela Doherty and Huw D. Jones -- Floral transformation of wheat / Sujata Agarwal ... [et al.] -- Highly efficient agrobacterium-mediated transformation of wheat via in planta inoculation / Thierry Risacher ... [et al.] -- Barley transformation using biolistic techniques / Wendy A. Harwood and Mark A. Smedley -- Barley transformation using agrobacterium-mediated techniques / Wendy A. Harwood ... [et al.] -- Transformation of oats and its application to improving osmotic stress tolerance / Shahina B. Maqbool ... [et al.] -- Promoter sequences for defining transgene expression / Huw D. Jones and Caroline A. Sparks -- Down-regulation of gene expression by RNA-induced gene silencing / Silvia Travella and Beat Keller -- Gene insertion patterns and sites / Philippe Vain and Vera Thole -- Fluorescent in situ hybridization to detect transgene integration into plant genomes / Trude Schwarzacher -- Establishing substantial equivalence : transcriptomics / María Marcela Baudo ... [et al.] -- Establishing substantial equivalence : proteomics / Alison Lovegrove, Louise Salt, and Peter R. Shewry -- Establishing substantial equivalence : metabolomics / Michael H. Beale, Jane L. Ward, and John M. Baker -- Design and management of field trials of transgenic cereals / Zoltán Bedő, Mariann Rakszegi, and László Láng -- GM risk assessment / Penny A.C. Sparrow -- Transgenic wheat, barley and oats : future prospects / Jim M. Dunwell.
  • Mammalian transglutaminases : a family portrait / Mehta, K. -- Structure-function relationships of transglutaminases, a contemporary view / Nemes, Z., Csosz, E., Fesus, L. -- Transglutaminases and their substrates / Facchiano, F., Facchiano, A. -- Type 2 transglutaminase and cell death / Piacentini, M. ... [et al.] -- Transglutaminase and cell-survival signaling / Singh, U.S., Pan, J. -- Transglutaminases in wound healing and inflammation / Verderio, E.A.M., Johnson, T.S., Griffin, M. -- Transglutaminases in epidermis / Eckert, R.L. ... [et al.] -- Tissue transglutaminase (TG2) in cancer biology / Mangala, L.S., Mehta, K. -- Transglutaminases in neurodegenerative disorders / Bailey, C.D.C., Tucholski, J., Johnson, G.V.W. -- Tissue transglutaminase and celiac disease / Esposito, C. ... [et al.] -- Transglutaminases as biotechnological tools / Mariniello, L., Porta, R. -- Extracellular transglutaminase: factor XIII / Ichinose, A. -- Transglutaminases of lower organisms / Rao, R.U., Chandrashekar, R., Mehta, K. -- Transglutaminases of higher, lower plants and fungi / Del Duca, S., Serafini-Fracassini, D.
  • The first authoritative and comprehensive survey of the origins and current state of transhumanist thinking The rapid pace of emerging technologies is playing an increasingly important role in overcoming fundamental human limitations. Featuring core writings by seminal thinkers in the speculative possibilities of the posthuman condition, essays address key philosophical arguments for and against human enhancement, explore the inevitability of life extension, and consider possible solutions to the growing issues of social and ethical implications and concerns.
  • 1. The transition process: initial assessment and development of a treatment plan -- 2. Approach to the myelodysplasia patient -- 3. Approach to the exstrophy patient -- 4. Approach to the adult hypospadias patient -- 5. Sexual function and pregnancy in the female myelodyspasia patient -- 6. Revision genitoplasty, sexual function, fertility, and pelvic organ prolapse in exstrophy and the management of pregnancy -- 7. Issues in the long-term management of adolescents and adults with DSD: management of gonads, genital reconstruction, and late presentation of the undiagnosed DSD -- 8. The adult hypospadias patient: technical challenges in adulthood -- 9. Urinary tract infections in the reconstructed bladder: evaluation and treatment options -- 10. Troubleshooting continent catheterizable channels -- 11. Augmentation cytosplasty: risks for malignancy and suggestions for follow-up evaluations -- 12. BPH and pelvic organ prolapse in patients with neurogenic bladder -- 13. Posterior urethral valves in adolescents: clinical problems, management, and follow-up -- 14. Renal transplantation in patients with lower urinary tract dysfunction -- 15. Management of calculi in patients with congenital neuropathic bladder -- 16. Vesicoureteral reflux and the adult -- 17. Adult survivors of pediatric genitourinary tumors -- Index.
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    Conceptual foundations and philosophy -- Practical application of the guides -- Pain-related impairment -- The cardiovascular system -- The pulmonary system -- The digestive system -- The urinary and reproductive systems -- The skin -- The hematopoietic system -- The endocrine system -- Ear, nose, throat, and related structures -- The visual system -- The central and peripheral nervous system -- Mental and behavioral disorders -- The upper extremities -- The lower extremities -- The spine and pelvis.
  • Insights into Structural Basis of Mammalian Mitochondrial Translation / Manjuli R. Sharma, Prem S. Kaushal -- Mechanism and Regulation of Protein Synthesis in Mammalian Mitochondria / Emine C. Koc, Hasan Koc -- Translation in Mammalian Mitochondria: Order and Disorder Linked to tRNAs and Aminoacyl-tRNA Synthetases / Catherine Florentz, Joern Pütz -- Mitochondrial Targeting of RNA and Mitochondrial Translation / Ivan Tarassov, Ivan Chicherin, Yann Tonin -- Mechanisms and Control of Protein Synthesis in Yeast Mitochondria / Steffi Gruschke, Martin Ott -- Kinetoplast-Mitochondrial Translation System in Trypanosomatids / Dmitri A. Maslov, Rajendra K. Agrawal -- Translation in Mitochondria and Apicoplasts of Apicomplexan Parasites / Ankit Gupta, Afreen Haider, Suniti Vaishya -- Mitochondrial Translation in Green Algae and Higher Plants / Thalia Salinas, Claire Remacle -- Translation in Chloroplasts of Flowering Plants / Masahiro Sugiura -- The Chloroplasts as Platform for Recombinant Proteins Production / Nunzia Scotti, Michele Bellucci.
  • Purification of FLAG-tagged eukaryotic initation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae / Sarah S. Mohammad-Qureshi ... [et al.] -- In vivo deletion analysis of the architecture of a multiprotein complex of translation initiation factors / Klaus H. Nielsen and Leos̆ Valás̆ek -- An approach to studying the localization and dynamics of eukaryotic translation factors in live yeast cells / Susan G. Campbell and Mark P. Ashe -- In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum / Samuel B. Stephens and Christopher V. Nicchitta -- Mammalian stress granules and processing bodies / Nancy Kedersha and Paul Anderson -- Methods to analyze micro-RNA-mediated control of mRNA translation / Jennifer L. Clancy ... [et al.] -- Methods for studying signal-dependent regulation of translation factor activity / Xuemin Wang and Christopher G. Proud -- Analysis of mRNA translation in cultured hippocampal neurons / Yi-Shuian Huang and Joel D. Richter -- Detecting ribosomal association with the 5' leader of mRNAs by ribosome density mapping (RDM) / Naama Eldad and Yoav Arava -- Genome-wide analysis of mRNA polysomal profiles with spotted DNA microarrays / Danial Melamed and Yoad Arava -- Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability / Ewa Grudzien-Nogalska ... [et al.] -- Methods for identifying compounds that specifically target translation / Letizia Brandi ... [et al.] -- Identifying small molecule inhibitors of eukaryotic translation initiation / Regina Cencic, Francis Robert, and Jerry Pelletier -- Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product pateamine A / Woon-Kai Low ... [et al.].
  • Use of reticulocyte lysates for mechanistic studies of eukaryotic translation initiation / William C. Merrick and Diane Barth-Baus -- Studying translational control in Drosophila cell-free systems / Fátima Gebauer and Matthias W. Hentze -- Use of in vitro translation extract depleted in specific initiation factors for the investigation of translational regulation / Daniel R. Gallie -- A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus in RNA genomes / Yuri V. Svitkin and Nahum Sonenberg -- A practical approach to isolate 48S complexes : affinity purification and analyses / Nicolas Locker and Peter J. Lukavsky -- Yeast phenotypic assays on translational control / Bumjun Lee ... [et al.] -- Localization and characterization of protein-protein interaction sites / Chingakham Ranjit Singh and Katsura Asano -- In vivo stabilization of preinitiation complexes by formaldehyde cross-linking / Leos Valás̆ek ... [et al.] -- Molecular genetic structure-function analysis of translation initiation factor elF5B / Byung-Sik Shin and Thomas E. Dever -- The use of fungal in vitro systems for studying translational regulation / Cheng Wu ... [et al.] -- Investigating translation initiation using drosophila molecular genetics / Gritta Tettweiler and Paul Lasko -- Analysis of RNA:protein interactions in vivo : identification of RNA-binding partners of nuclear factor 90 / Andrew M. Parrott, Melissa R. Walsh, and Michael B. Mathews -- Approaches for analyzing the differential activities and functions of elF4E family members / Robert E. Rhoads, Tzvetanka D. Dinkova, and Rosemary Jagus -- Tethered function assays : an adaptable approach to study RNA regulatory proteins / Jeff Coller and Marv Wickens -- Analysis of ribosomal shunting during translation initiation in eukaryotic mRNAs / Vincent P. Mauro, Stephen A. Chappell and John Dresios.
  • Transient kinetics, flourescence, and FRET in studies of initiation and translation in bacteria / Pohl Milon ... [et al.] -- Binding of mRNA to the bacterial translation initiation complex / Sean M. Studer and Simpson Joseph -- Real-time dynamics of ribosome-ligand interaction by time-resolved chemical probing methods / Attilio Fabbretti ... [et al] -- Overexpression and purification of mammalian mitochondrial translational initiation factor 2 and initiation factor 3 / Domenick G. Grasso ... [et al.] -- In vitro studies of archaeal translational initiation / Dario Benelli and Paola Londei -- Reconstitution of yeast translation initiation / Michael G. Acker ... [et al.] -- Assembly and analysis of eukaryotic translation initiation complexes / Andrey V. Pisarev -- Reconstitution of mammalian 48S ribosomal translation initiation complex / Romit Majumdar, Jayanta Chaudhuri, and Umadas Maitra -- Biophysical approach to studies of Cap-elF4E interaction by synthetic cap analogs / Anna Niedzwiecka ... [et al.] -- Biophysical studies of the translation initiation pathway with immobilized mRNA analogs / John E. G. McCarthy, Steven Marsden, and Tobias von der Haar -- Protection-based assays to measure aminoacyl-tRNA binding to translation initiation factors / Yves Mechulam ... [et al.] -- NMR methods for studying protein-protein interactions involved in translation initiation / Assen Marintchev, Dominique Frueh, and Gerhard Wagner -- Structural methods for studying IRES function / Jeffrey S. Kieft ... [et al.].
  • Pathophysiology of Heart Failure: Back to Basics -- Heart Failure with Normal Left Ventricular Ejection Fraction -- Basic Principles and Clinical Diagnostics -- 17 Cardiorenal Syndrome Revisited -- Doppler Echocardiography in the Clinical Evaluation of Heart Failure: What Clinicians Need to know and Echocardiographers Should Report -- Back to Earth: 'Common sense' in the Management of Heart Failure -- Atrial Fibrillation and Heart Failure: Rate versus Rhythm Control -- Repetitive ICD Shocks and Incessant VTs in Heart Failure: What to Do? -- Dyssynchronous Heart Failure: From Bench to Bedside -- 18 Telemonitoring and Sensor Technologies in Chronic Heart Failure -- Functional Mitral Regurgitation: the Surgeons's Perspective -- Percutaneous Approaches to Treat Functional Mitral Regurgitation: Current State of Affairs and Future Perspectives -- Tailored Approach to Functional Mitral Regurgitation -- Revascularization and Left Ventricular Reconstruction in a Patient with Ischemic Heart Failure: to STICH or not to STICH? -- Cardiac arrest en Refractory Cardiogenic Shock -- Left Ventricular Assist Devices -- From Bridge to Transplant to Destination Therapy -- Novel Device-based Strategies in Treatment of Chronic Heart Failure -- Total Artificial Heart -- Stem Cell Therapy for Ischemic Heart Disease -- Immunosuppressive Management of the Heart Transplant Recipient.
  • Translational bioinformatics v. 1-, 2012-
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  • Pt. I. The rationale for translational informatics -- An introduction to translational informatics and the future of knowledge-driven healthcare -- A prototype of translational informatics in action -- pt. II. Foundations of translational informatics -- Personalized medicine -- Leveraging electronic health records for phenotyping -- Mining the bibliome -- pt. III. Applications of translational informatics -- Driving clinical and translational research using biomedical informatics -- Using big data -- In silico hypothesis discovery -- Patient engagement and consumerism -- pt. IV. The future of translational informatics and knowledge-driven healthcare -- Future directions for translational informatics.
  • Chapter 1. Translational Medicine / Dennis Cosmatos, Shein-Chung Chow -- Chapter 2. Strategic Concepts in Translational Medicine / Dennis Cosmatos, Giora Feuerstein, Shein-Chung Chow -- Chapter 3. Design and Analysis Approaches for Discovery Translational Medicine / Dennis Cosmatos, Shein-Chung Chow (Eds.), Stephen B. Forlow, Jennifer A. Isler, Zhaosheng Lin, Michael E. Burczynski, Jessie Q. Xia, S. Stanley Young -- Chapter 4. Biomarker Development / Mark Chang -- Chapter 5. Targeted Clinical Trials / Jen-pei Liu -- Chapter 6. Statistical Methods in Translational Medicine / Shein-Chung Chow, Siu-Keung Tse, Dennis Cosmatos -- Chapter 7. Nonparametric Methods in Translational Research / Kongming Wang, Shein-Chung Chow -- Chapter 8. Model Selection/Validation / Jen-pei Liu -- Chapter 9. Translation in Clinical Information between Populations-Bridging Studies / Chin-Fu Hsiao, Mey Wang, Herng-Der Chern, Jen-pei Liu -- Chapter 10. Translation in Clinical Technology-Traditional Chinese Medicine / Chin-Fu Hsiao, Hsiao-Hui Tsou, Shein-Chung Chow.
  • Chapter 1. Introduction to Translational Medicine -- Chapter 2. New Light Through an Old Window? The "Translational Turn" in Biomedical Research -- Chapter 3. Translational Medicine -- Drivers and Barriers of TM -- Chapter 5. Developing an Evaluation Model for Translational Medicine Research Programs -- Chapter 6. Emerging Concepts in Biomarker Discovery -- Chapter 7. Imaging Biomarkers for Innovative Drug Development -- Chapter 8. Translational Bioinformatics -- Chapter 9. Exploiting Translational Medicine Through Public- Private Partnerships -- Chapter 10. The Role of the Product Development Partnership as a Translational Mechanism for Delivering Health Solutions in Low- Resource Settings.
  • Principles of cerebral ultrasound contrast imaging / Powers, J., Averkiou, M. -- Physical principles of microbubbles for ultrasound imaging and therapy / Stride, E. -- Ultrasound bio-effects and safety considerations / Ter Haar, G. -- Intima-media thickness of carotid arteries / Touboul, P.-J. -- Functional TCD : regulation of cerebral hemodynamics, cerebrovascular autoregulation, vasomotor reactivity, neurovascular coupling / Wolf, M.E. -- Intracranial perfusion imaging with ultrasound / Meairs, S., Kern, R. -- Parenchymal imaging in movement disorders / Fernandes, R.C.L., Berg, D. -- Sonothrombolysis / Meairs, S. -- Non-invasive transcranial brain ablation with high-intensity focused ultrasound / Jenne, J.W. -- Ultrasound-induced blood-brain barrier opening for drug delivery / Alonso, A.
  • Painful multi-symptom disorders : a systems perspective / C. Richard Chapman -- Neurotrophic factors and nociceptor sensitization / Michael P. Jankowski and H. Richard Koerber -- The role of visceral afferents in disease / Julie A. Christianson and Brian M. Davis -- Cancer pain : from the development of mouse models to human clinical trials / Juan Miguel Jimenez Andrade and Patrick Mantyh -- Therapeutic targeting of peripheral cannabinoid receptors in inflammatory and neuropathic pain states / Igor Spigelman -- Molecular strategies for therapeutic targeting of primary sensory neurons in chronic pain syndromes / Ichiro Nishimura ... [et al.] -- Transgenic mouse models for the tracing of "pain" pathways / Allan I. Basbaum and João M. Bráz -- Cytokines in pain / Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers -- Glial modulation in pain states : translation into humans / Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo -- On the role of ATP-gated P2X receptors in acute, inflammatory, and neuropathic pain / Estelle Toulme ... [et al.] -- Myalgia and fatigue : translation from mouse sensory neurons to fibromyalgia and chronic fatigue syndromes / Alan R. Light, Charles J. Vierck, and Kathleen C. Light -- Reflex autonomic responses evoked by group III and IV muscle afferents / Jennifer L. McCord and Marc P. Kaufman -- Central pain as a thalamocortical dysrhythmia : a thalamic efference disconnection? / Kerry D. Walton and Rodolfo R. Llinás -- What can neuroimaging tell us about central pain? / D.S. Veldhuijzen ... [et al.] -- Human brain imaging studies of chronic pain : translational opportunities / A. Vania Apkarian -- Consideration of pharmacokinetic pharmacodynamic relationships in the discovery of new pain drugs / Garth T. Whiteside and Jeffrey D. Kennedy -- Large animal models for pain therapeutic development / Darrell A. Henze and Mark O. Urban -- Drug discovery and development for pain / Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers.
  • This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
  • For many years, the ethical discussion surrounding human embryonic stem cell research has focused on the moral status of the embryo. This text takes a wider moral berth and focuses on numerous ethical, legal and social aspects involved in translating the results of stem cell research into diagnostic and therapeutic applications.
  • Pt. 1. Theoretical overview -- pt. 2. Mechanisms and targets -- pt. 3. Translational models -- pt. 4. De-risking of drug candidates -- pt. 5. Therapy delivery -- pt. 6. Therapy development -- pt. 7. Clinical trial design.
  • Section I. Hot topics in vascular biology -- Section II. Novel molecular mediators regulating cardiovascular system -- Section III. Clinical aspects of cardiovascular disease -- Section IV. Clinical and translational aspects of pulmonary vascular disease -- Index.
  • Bioluminescence resonance energy transfer to monitor protein-protein interactions / Tarik Issad and Ralf Jockers -- Identification of interacting proteins using the yeast two-hybrid screen / Kelly L. Jordan-Sciutto and Marshall B. Montgomery -- Analysis of PDZ domain interactions using yeast two-hybrid and coimmunoprecipitation assays / Hyun Woo Lee, Jaewon Ko, and Eunjoon Kim -- Clustering assay for studying the interaction of membrane proteins with PDZ domain proteins / Jaewon Ko and Eunjoon Kim -- Mammalian cell microinjection assay to study the function of Rho family guanosine triphosphatases / Ritu Garg and Anne J. Ridley -- Affinity-based assay of Rho guanosine triphosphatase activation / Mary Stofega, Celine DerMardirossian, and Gary M. Bokoch -- Assay for phospholipase D in cell-free systems / Shankar S. Iyer and David J. Kusner -- Reconstitution system based on cytosol-depleted cells to study the regulation of phospholipase D / Amanda Fensome-Green and Shamshad Cockcroft -- Analysis of global gene expression profiles activated by chemoattractant receptors / Fernando O. Martinez and Massimo Locati -- Genetic reconstitution of bone marrow for the study of signal transduction ex vivo / Martha S. Jordan -- Proteomic analysis of human neutrophils / George Lominadze ... [et al.]. Transmembrane signaling by G protein-coupled receptors / Louis M. Luttrell -- Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases / Kanchana Nataranjan and Bradford C. Berk -- Protein-protein interactions in signaling cascades / Bruce J. Mayer -- Biological role of the CXCR4-SDF-1 axis in normal human hematopoietic cells / Marcin Majka and Mariusz Z. Ratajczak -- Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4 / Zi-xuan Wang, James R. Broach, and Stephen C. Peiper -- Characterization of constitutively active mutants of G protein-coupled receptors / Jean-Marc Navenot, Zi-xuan Wang, and Stephen C. Peiper -- G protein-coupled receptor dimerization and signaling / Mario Mellado ... [et al.] -- Real-time analysis of G protein-coupled receptor signaling in live cells / Venkatakrishna R. Jala and Bodduluri Haribabu -- Isolation of membrane rafts and signaling complexes / Kathleen Boesze-Battaglia -- Methods for the study of signaling molecules in membrane lipid rafts and caveolae / Rennolds S. Ostrom and Paul A. Insel --
  • "The diagnosis and treatment of the diseases of the skull base have changed dramatically in the past few years, transforming the fields of neurosurgery and otolaryngology-head and neck surgery. The increasing advances in these fields have addressed the ENT physicians and neurosurgeons to keep up with the expanding information in the exciting area of skull base. By publishing this book, we are presenting a multidisciplinary approach to the lesions of the skull base. We bring chapters written by the most experienced groups around the world with both, basic information and the latest advances in macro and surgical anatomy, radiology, anesthesia, endocrinology, and all modalities of transnasal endoscopic assisted surgical approaches to the anterior, middle, posterior, zygomatic and infra temporal fossae. In addition, the extended approaches such as to the craniocervical junction and petrous apex are also addressed. Especial emphasis is also given to the reconstruction techniques"--Provided by publisher.
  • Recent research in health decision making has shown that many patients, even those with a college education, have difficulties grasping a host of numerical concepts, including percentages and probabilities. Yet, basic numeracy and graph literacy are essential for understanding information relevant to making decisions about health, such as the incidence and prevalence of different diseases, risk reductions from medical screenings and treatments, and risk increases from side effects of treatments and unhealthy behaviors. Patients who have problems understanding such numerical concepts are often prone to errors in risk perception and medical choices. Importantly, informed medical decision making, heavily reinforced these days by the legal requirement for informed consent, depends critically on communication of quantitative medical information. Meeting the challenge of effectively communicating medical information to patients with different levels of numeracy and graph literacy has become more important than ever. Transparent Communication of Health Risks describes a series of cross-cultural studies investigating how people in countries with different medical and educational systems understand numerical and graphical information, what they know about existing medical treatments and screenings, which presentation formats help them better understand the relevant information, and how they use the data to make medical decisions. Focusing on the careful measurement of necessary knowledge and skills, the book also includes validated numeracy and graph literacy scales in English, Spanish, and German. Some of the topics covered in the book are:numeracy and graph literacy for health;measuring risk comprehension in educated samples;communicating information about medical treatment and screening;reducing the effect of framed messages about health;the effect of individual differences on shared decision making; andtransparent health information in the media.Transparent Communication of Health Risks emphasizes the importance and value of working toward the development of tailored risk communication interventions and clarifies the tasks ahead for health psychologists, public health professionals, pharmaceutical and medical education companies, medical physicists, and nurses.
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    " In The Transplant Imaginary, author Lesley Sharp explores the extraordinarily surgically successful realm of organ transplantation, which is plagued worldwide by the scarcity of donated human parts, a quandary that generates ongoing debates over the marketing of organs as patients die waiting for replacements. These widespread anxieties within and beyond medicine over organ scarcity inspire seemingly futuristic trajectories in other fields. Especially prominent, longstanding, and promising domains include xenotransplantation, or efforts to cull fleshy organs from animals for human use, and bioengineering, a field peopled with "tinkerers" intent on designing implantable mechanical devices, where the heart is of special interest. Scarcity, suffering, and sacrifice are pervasive and, seemingly, inescapable themes that frame the transplant imaginary. Xenotransplant experts and bioengineers at work in labs in five Anglophone countries share a marked determination to eliminate scarcity and human suffering, certain that their efforts might one day altogether eliminate any need for parts of human origin. A premise that drives Sharp's compelling ethnographic project is that high-stakes experimentation inspires moral thinking, informing scientists' determination to redirect the surgical trajectory of transplantation and, ultimately, alter the integrity of the human form. "-- Provided by publisher.
  • Alloreactivity / Sidonia B.G. Eckle, Jamie Rossjohn, and James McCluskey -- Antibodies in Transplantation : The Effects of HLA and Non- HLA Antibody Binding and Mechanisms of Injury / Nicole M. Valenzuela and Elaine F. Reed -- Cell Mediated Rejection / Kathryn J. Wood, Masaaki Zaitsu, and Ryoichi Goto -- Transplantation Tolerance / Colin Brinkman ... [et al.] -- Composite Tissue Transplantation / Gerald Brandacher -- Transplantation of the Sensitized Patient: Histocompatibility Testing / Robert A. Montgomery, Mary S. Leffell, and Andrea A. Zachary -- Thoracic Organ Transplantation : Laboratory Methods / Jignesh K. Patel and Jon A. Kobashigawa -- HLA Typing by Sequence-Specific Primers / Mike Bunce and Ben Passey -- Human Leukocyte Antigen (HLA) Typing by DNA Sequencing / Ana Lazaro ... [et al.] -- Next-Generation HLA Sequencing Using the 454 GS FLX System / Elizabeth A. Trachtenberg and Cherie L. Holcomb -- Chimerism Testing by Quantitative PCR Using Indel Markers / Ketevan Gendzekhadze, Laima Gaidulis, and David Senitzer -- Gene-Specific PCR Typing of Killer Cell Immunoglobulin- Like Receptors / Raja Rajalingam and Elham Ashouri -- Complement-Dependent Cytotoxicity Crossmatch / Jeremy Ryan Pena, Donna Fitzpatrick, and Susan L. Saidman -- Lymphocyte Crossmatching by Flow Cytometry / Robert A. Bray -- Solid Phase Assay Measuring C4d Deposition to Determine Complement Fixation by HLA-Specific Antibodies / John D. Smith and Marlene L. Rose -- C1q Assay for the Detection of Complement Fixing Antibody to HLA Antigens / Ge Chen and Dolly B. Tyan -- Tetramer Staining for the Detection of HLA-Specific B cells / Donna P. Lucas, Mary S. Leffell, and Andrea A. Zachary -- Flow Cytometric Crossmatch Test Using Endothelial Precursor Cells Isolated from Peripheral Blood / Annette M. Jackson, Donna P. Lucas, and Jessica L. Badders -- Detection of Antibodies to the Angiotensin II-Type 1 Receptor in Transplantation / Duska Dragun -- Detection of Antibodies to Self-Antigens (K-alpha 1 Tubulin, Collagen I, II, IV, and V, Myosin, and Vimentin) by Enzyme-Linked Immunosorbent Assay (ELISA) / Nayan J. Sarma, Venkataswarup Tiriveedhi, and T. Mohanakumar -- Cylex ImmuKnow Cell Function Assay / Adriana Zeevi and John Lunz -- Detection of Intracellular Cytokines / Nancy L. Reinsmoen and Chih-Hung Lai -- Tolerogenic Dendritic Cells and Induction of T Suppressor Cells in Transplant Recipients / George Vlad and Nicole Suciu-Foca -- Discovery and Customized Validation of Antibody Targets by Protein Arrays and Indirect ELISA / Tara K. Sigdel and Minnie M. Sarwal -- RNA Purification and Expression Analysis Using Microarrays and RNA Deep Sequencing / Steven R. Head ... [et al.].
  • The establishment of composite tissue allotransplantation as a clinical reality / Joseph E. Murray -- The evolution of composite tissue allotransplantation: the twentieth century realization of "Cosmas and Damian" / Chad R. Gordon ... [et al.] -- The impact of the discovery of cyclosporine on transplantation of composite tissue allografts / Zsolt T. Csapo, Bence Forgacs, and Barry D. Kahan -- The first limb transplants with cyclosporine / Christopher J. Salgado, Samir Mardini, and Charles W. Hewitt -- Translational research in composite tissue allotransplantation / Linda C. Cendales, David E. Kleiner, and Allan D. Kirk -- Relative antigenicity of allograft components and differential rejection / Jignesh Unadkat ... [et al.] -- On the road to tolerance induction in composite tissue allotransplantation / Mark A. Hardy -- Donor-specific tolerance / Au H. Bui, Gerald Lipshutz, and Jerzy Kupiec-Weglinski -- Immune tolerance induction: basic concepts for composite tissue allotransplantation / Patricio Andrades, Clement Asideu, and Judith M. Thomas -- Allograft survival with calcineurin inhibitors / Neil F. Jones and Esther Voegelin -- Long-term prevention of rejection and combination drug therapy / Thomas H. Tung -- Locoregional immunosuppression in composite tissue allografting / Scott A. Gruber -- New approaches to antibody therapy / Dalibor Vasilic, Moshe Kon, and Cedric G. Francois -- World experience of hand transplantation-independent assessment / W.P. Andrew Lee, Justin M. Sacks, and Elaine K. Horibe -- Hand transplantation: Lyon experience / Palmina Petruzzo ... [et al.] -- Hand transplantation: the Louisville experience / Vijay S. Gorantla and Warren C. Breidenbach III -- Hand transplantation: the Innsbruck experience / Stefan Schneeberger, Marina Ninkovic, and Raimund Margreiter -- Vascularized bone marrow transplantation / Chau Y. Tai ... [et al.] -- Vascularized bone marrow transplantation: pathology of composite tissue transplantation-induced graft-versus-host-disease / Rajen Ramsamooj and Charles W. Hewitt -- Immune cell redistribution after vascularized bone marrow transplantation / Waldemar L. Olszewski and Marek Durlik -- Vascularized knee transplantation / Michael Diefenbeck and Gunther O. Hofmann -- Tracheal transplantation / Gabriel M. Marta and Walter Klepetko -- Laryngeal transplantation / Robert R. Lorenz and Marshall Strome -- Face transplantation / Maria Siemionow and Galip Agaoglu -- The role of allografts in lower extremity reconstruction / Milton B. Armstrong, Ricardo Jimenez-Lee, and Eddie Manning -- Skin allografts in scalp reconstruction / Peter C. Neligan -- Abdominal wall transplantation / Chau Y. Tai and Susan E. Mackinnon -- Live-donor nerve transplantation / Scott A. Gruber and Pedro Mancias -- Ethical and policy concerns of hand/face transplantation / Rhonda Gay Hartman -- Ethical debate on human face transplantation / François Petit -- Psychosocial issues in composite tissue allotransplantation / Barckley Storey ... [et al.] -- Composite tissue transplantation in the twenty-first century / Kirby S. Black and Charles W. Hewitt.
  • Anatomy and physiology of the spinal cord / Antal Nógrádi and Gerta Vrbová -- Recovery of function after spinal cord injury / Gavin Clowry and Urszula Slawinska -- Recovery of lost spinal cord function by facilitating the spinal cord circuits below the lesion / Urszula Slawinska -- Encouraging regeneration of host neurones: the use of peripheral nerve bridges, glial cells or biomaterials / Antal Nógrádi -- Encouraging regeneration of host neurons: transplantation of neural tissues into the injured spinal cord grafts of embryonic neural tissue / Gerta Vrbová -- Replacement of specific neuronal populations in the spinal cord / Antal Nógrádi -- Replacement of specific populations of cells: glial cell transplantation into the spinal cord / Antal Nógrádi.
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  • Drs. Busuttil and Klintmalm present Transplantation of the Liver, 3rd Edition, which has been thoroughly revised to offer you the latest protocols, surgical approaches, and techniques used in this challenging procedure. Encompassing today's expert knowledge in the field, this medical reference book is an ideal single source for authoritative, up-to-date guidance on every imaginable aspect of liver transplantation. Understand today's full range of transplantation techniques with complete step-by-step descriptions of each, and access the background information and management options for each hepatic disease entity. Take advantage of detailed discussions of everything from pathophysiology and patient and donor selection, to transplantation anesthesia and operative procedures; immunosuppression; postoperative care; and ethical issues.
  • Controversies in the ethics of organ transplantation / Marc J. Clancy and Alex T. Vesey -- Organ donation in the UK : recent progress and future challenges / Christopher J. Rudge -- Immunology of graft rejection / George Tse and Lorna Marson -- Testing for histocompatibility / Phil Dyer, Ann-Margaret Little and David Turner -- Immunosuppression with the kidney as paradigm / David Wojciechowski, Gregory Veillette and Flavio Vincenti -- Preservation and perfusion of abdominal organs for transplantation / John O'Callaghan, Peter Friend and Rutger J. Ploeg -- Recent trends in kidney transplantation / Gabriel C. Oniscu -- Liver transplantation / James J. Pomposelli, Mary Ann Simpson, Caroline Simon and Elizabeth A. Pomfret -- Pancreas transplantation / Murat Akyol -- Islet transplantation / John J. Casey -- Cardiothoracic transplantation / Asif Hasan and John H. Dark -- Transplant infectious disease / Camille Nelson Kotton -- Chronic transplant dysfunction / Shikha Mehta and Roslyn B. Mannon.
  • Transport in Biological Media is a solid resource of mathematical models for researchers across a broad range of scientific and engineering problems such as the effects of drug delivery, chemotherapy, or insulin intake to interpret transport experiments in areas of cutting edge biological research. A wide range of emerging theoretical and experimental mathematical methodologies are offered by biological topic to appeal to individual researchers to assist them in solving problems in their specific area of research. Researchers in biology, biophysics, biomathematics, chemistry, engineers and clinical fields specific to transport modeling will find this resource indispensible. Provides detailed mathematical model development to interpret experiments and provides current modeling practices Provides a wide range of biological and clinical applicationsIncludes physiological descriptions of models.
  • Transporters in Drug Development is a corner stone in a high profile book series on advances in pharmaceutical sciences initiated by AAPS, Springer and Professor Daan Crommelin as series Editor. Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation list chapters written by leading researchers in the transporter field from academia, pharmaceutical industry and medicines agencies. The book encompasses examples and advises on how membrane transporters can be dealt with in academic industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. Methods and examples of in vitro characterization of single transporters in intestine, liver and kidney are described as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are discussed as well as the perspectives of applying targeted proteomics and mechanistic modelling in this process.
  • Transsphenoidal Surgery, by Drs. Laws and Lanzino, captures all of today's clinical knowledge on the multidisciplinary management of pituitary tumors, with a focus on surgical techniques. Acclaimed international experts bring you detailed guidance on natural history, radiologic and clinical aspects, surgical indications, and resection techniques. What₂s more, case presentations and clinical photographs help you reduce the risk of error and advance your own surgical skills. At, you'll have online access to the full text plus streaming videos of key procedures to help you provide the best possible outcomes for every patient. Access the fully searchable text online at and view hours of videos in which experts demonstrate how to perform key procedures. Refine your skills through discissions of intraoperative imaging, new techniques in transsphenoidal surgery, new microsurgical procedures, radiosurgical techniques, and more. Get balanced and comprehensive perspectives on pituitary surgery from well-recognized international, multidisciplinary contributors. Make better-informed decisions with case presentations, drawn from Dr. Laws's 40 plus years as a leader in pituitary surgery, that include a summary of the clinical history, preoperative radiographs, and postoperative clinical information and radiographs. Tap into exceptional visual guidance and reduce the risk of error through abundant clinical photographs, line drawings, and procedural videos. Find the information you need quickly via a consistent chapter-to-chapter organization.
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    1. Análisis de la sangre.
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    v. 1., fasc. 1. Echinococcus granulosus.
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  • Introduction -- The Relevance of Trauma in Immigrants -- Cross-cultural Communication with Traumatised Immigrants -- Cross-cultural Competence in Handling with Traumatised Immigrants -- Clinical Diagnostic of Traumatised Immigrants -- Treatment Process of Traumatized immigrant Children and Adolescent -- Trauma-centered Therapy with EMDR -- Refugees and Asylum Seeker and Trauma -- Expert Opinion of Traumatised Immigrants -- Injured Helper -- Immigrants in an Outpatient Clinic for Traumatised Immigrants -- Cross-cultural Psychotherapy with Immigrants from Operational Zone -- Therapy Concept for Traumatised Refugees in Denmark -- Rethinking Trauma as a Global Challenge.
  • Reporting on classification systems which are currently utilised in the clinical setting, this illustrated guide is an essential resource for all young clinicians and researchers of Trauma and Orthopaedics. Each chapter of the different anatomical sites and pathologies is designed to assist the decision making of the readers regarding treatment strategy as well as informed consent of their patients. Trauma and Orthopaedic Classifications: A Comprehensive Overview includes classifications relevant to both Elective Orthopaedic Practice and Orthopaedic Trauma. Clear graphic illustrations accompany the description of all different classification schemes in a comprehensive manner, together with a structured presentation of existing clinical evidence. Surgeons in training right through to senior surgeons and academic clinicians will find this book to be a key reference to formulate the right decisions in their clinical practice.
  • Trauma Management in Orthopedics has been written to serve as a general introduction to the field of trauma in the field of orthopedics. It is composed of a number of commonly seen disorders and with a corresponding therapeutic pathway, clearly explained with numerous xrays and diagrams to aid the reader in their understanding of these useful procedures.The book is intended as a basic resource for trainees and junior surgeons, but will also be useful to more experienced specialists who require an easy to follow clinical guide to assist in day to day practice of orthopedic trauma management.
  • Trauma surgery has increasingly become a specialized field inspired by different principles and philosophy. A good trauma surgeon is a surgeon who knows how to perform abdominal vascular, thoracic, urologic, gynecologic, and orthopaedic procedures and is able to repair multiple traumatic injuries in the best sequence possible. In this first volume, practical, up-to-date guidance is provided on the optimal critical care and ICU management of trauma patients. In addition, individual chapters focus on specific injuries in orthopaedic trauma (and especially spinal trauma) and neurotrauma, with the aim of providing a fresh view of the surgical approach and practical suggestions for improving the skills of treating surgeons. Educational issues and the organization of a trauma center are also covered. The volume will be a handy pocket guide for trainee surgeons and any surgeon, physician, or nurse who treats trauma patients. It will be particularly relevant for emergency department physicians, critical care and ICU doctors, orthopaedic surgeons, neurosurgeons, and professionals responsible for trauma care and decision making, programs of trauma education, or organization of a trauma center.
  • Trauma surgery has increasingly become a specialized field inspired by different principles and philosophy. A good trauma surgeon is a surgeon who knows how to perform abdominal, vascular, thoracic, urologic, gynecologic, and orthopaedic procedures and is able to repair multiple traumatic injuries in the best sequence possible. In this second volume the focus is exclusively on thoracic and abdominal trauma, with coverage of injuries to all regions. The surgical techniques employed in managing such trauma are carefully described with the aid of high-quality illustrations. Exploratory surgery (via either laparotomy or laparoscopy), damage control surgery, and definitive surgery are all fully covered, and attention is drawn to important technical tips and tricks. The volume will be a handy pocket guide for trainee surgeons who are beginning to deal with severe multiple trauma patients, as well as for all general or specialty surgeons and professionals (including scrub nurses and theatre staff) who are involved in trauma care and wish to keep abreast of developments in this complex field.
  • This volume delivers broad, practical knowledge of trauma diagnosis and management in a high-yield format that enables quick mastery of the material. A consistent organization by body region, summary tables and boxes, bulleted lists, and detailed artwork make this reference perfect for quick review of the essential knowledge.
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  • Trauma. 7th ed. 2013
    Kinematics -- Epidemiology -- Injury prevention -- Trauma systems, triage, and transport -- Injury severity scoring and outcomes research -- Acute care surgery -- Prehospital care -- Disaster and mass causalty -- Rural trauma -- Initial assessment and management -- Airway management -- Management of shock -- Postinjury hemotherapy and hemostasis -- Emergency department thoracotomy -- Diagnostic and interventional radiology -- Surgeon-performed ultrasound in acute care surgery -- Principles of anesthesia and pain management -- Infectons -- Injury to the brain -- Eye -- Face -- Neck -- Vertebrae and spinal cord -- Trauma thoracotomy: principles and techniques -- Lung, trachea, and esophagus -- Heart and thoracic vascular injuries -- Trauma laparotomy: principles and techniques -- Diaphragm -- Liver and biliary tract -- Injury to the spleen -- Stomach and small bowel -- Doudenum and pancreas -- Colon and rectal trauma -- Abdominal vascular injury -- Pelvis -- Genitourinary trauma -- Trauma in pregnancy -- Trauma damage control -- Upper extremity -- Lower extremity -- Periphearl vascular injury -- Alcohol and drugs -- The pediatric patient -- The geriatric patient -- Ethics of acute care surgery -- Social violence -- Wounds, bites, and stings -- Burns and radiation -- Temperature-related syndromes: hyperthermia, hypothermia, and frostbite -- Organ procurement for transplantation -- Rehabilitation -- Modern combat casualty care -- Genomics and acute care surgery -- Trauma, medicine, and the law -- Principles of critical care -- Cardiovascular failure -- Respiratory insufficiency -- Gastrointestinal failure -- Renal failure -- Nutritional support and electrolyte management -- Multiple organ failure.
  • Overview of TBI / David F. Moore, Michael S. Jaffee, Geoffrey Ling -- Imaging diagnosis of TBI / Tuong H. Le, Shirley I. Stiver, Alisa D. Gean -- Neurocognitive assessment of mTBI / W. Huw Williams, Seb Potter, Helen Ryland, Philip Yates, James Tonks & Adam Reuben -- Management of moderate and severe TBI / Scott A. Marshall, Randy Bell, Rocco A. Armonda, Geoffrey S.F. Ling -- Sports concussion / Sharon R. Weeks, Jack W. Tsao -- Blast-related concussion / Carson Lawall -- Sleep/wake disturbances in mild traumatic brain injury patients / Michael Russo, Aimee Alphonso, Ian Murphy -- Vestibular consequences of mTBI / Michael E Hoffer, Kim Gottshall, Erik S. Viirre -- Post-traumatic headache / Jay C. Erickson, Brett J. Theeler -- Seizures after TBI / John Betjemann, Karen Parko -- Endocrine disturbances following TBI / Victoria Tepe, Arthur Guerrero -- Confronting mild TBI and Co-occurring PTSD symptoms in combat deployed service members / Justin S. Campbell, Jeffrey H. Greenberg, Jennifer M. Weil -- Behavioral and psychiatric comorbidities of TBI / Robert L. Collins, Nicholas J. Pastorek, Andra L. Teten, Thomas A. Kent -- Rehabilitation of TBI / Mel Glenn -- Interventions to improve cognitive functioning after TBI / Anthony J.-W. Chen, Tatjana Novakovic-Agopian -- Current diagnostic and therapeutic challenges / Donald W. Marion.
  • Traumatic brain injury. Parts I-II pt. 1-2, 2015
    pt. 2 ScienceDirect
    The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI.
  • Distal femoral fractures -- Tibial plateau fractures -- Patellar fractures -- Patellar dislocations and osteochondral fractures -- Traumatic knee dislocation -- Floating knee -- Nonunion and malunion around the knee -- Knee extensor mechanism injuries -- Anterior cruciate ligament (ACL) injuries -- Runner's knee and pataellar tendinopathy.
  • "Treatment of traumatic injuries is increasing in importance for physical therapists active in hospitals and private practice. In addition to the bone, joint, and soft tissue injuries incurred in sports, physical therapists are seeing more and more traumas associated with aging and with high-speed accidents. This great variety of injury types increases the complexity of treatment. Moreover, in recent years there has been a growing demand for the most complete restoration possible of both physical and psychological function. This is the principal objective of aftercare. Accordingly, this book focuses on a comprehensive presentation of individual injuries and their effect on function, as well as the guidelines and potential results of physical therapy treatment. It is addressed to students, practitioners, and teachers of physical therapy who must master and apply an understanding of the whole range of injuries, their consequences, and their treatment. "--Provided by publisher.
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  • Here₂s a handy, portable guide to preventing, evaluating, and managing diseases that can be acquired in tropical environments and foreign countries! Whether you₂re a physician, traveler, or both, this respected manual is your perfect source for quick, easy access to the latest travel medicine information. New updates and additional material are presented in a sleek new design that offers rapid access to the content you need. The fourth edition features more critical content than ever before--including new evidence-based recommendations and new maps and illustrations. From pre-travel advice and immunizations to the diagnosis and treatment of a full range of travel-related illnesses, you₂ll have all the information you need to avoid, recognize, and treat illnesses acquired away from home in a convenient, pocket size guide. Illustrates key concepts with visual guidance from dynamic new images. Offers evidence-based treatment recommendations to enable you to manage diseases confidently. Provides access to need-to-know information quickly in a convenient, pocket size for excellent portability. Features 7 major sections, color-coded for quick answers: Pre-travel Advice Advice for Special Travelers Fever Diarrhea Skin Lesions Sexually Transmitted Diseases Worms.
  • Travel medicine. 3rd ed. 2013
    This 3rd Edition, by Jay S. Keystone, Phyllis E. Kozarsky, David O. Freedman, Hans D. Nothdruft, and Bradley A. Connor, prepares you and your patients for any travel-related illness they may encounter. Consult this resource for best practices on everything from immunizations and pre-travel advice to essential post-travel screening. From domestic cruises to far-flung destinations, this guide offers a wealth of practical guidance on all aspects of travel medicine. New to this edition: Effectively protect your patients before they travel with new information on immunizations and emerging and re-emerging disease strains, including traveler's thrombosis. Update your knowledge of remote destinations and the unique perils they present. Stay abreast of best practices for key patient populations, with new chapters on the migrant patient, humanitarian aid workers, medical tourism, and mass gatherings, as well as updated information on pediatric and adolescent patients.
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    General principles / Hans Steiner, Rebecca Hall, Julia Huemer -- Disruptive behavior disorders / Whitney Daniels, Michael Kelly, Kathleen Ares, Katie Kaszynski, Niranjan Karnik -- Attention-deficit/hyperactivity disorder (ADHD) / Michael Kelly -- Learning and executive cognitive functions / Ahmed Khan, Brianna Bendixsen, Lynne Baldwin, Diana Barrett, Richard Abbey.
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  • Intends to conceptualize aggression as a symptom of underlying behavioural and emotional problems and examines the psychology of perpetrators and the power dynamics that foster intentionally hurtful behaviour in young people. This book details how bibliotherapy offers relevant treatment and can be implemented with individuals and groups.
  • History of treatment in children with developmental disabilities and psychopathology / Jonathan Wilkins and Johnny L. Matson -- Applied behavior analysis and the treatment of childhood psychopathology and developmental disabilities / Joel E. Ringdahl and Terry S. Falcomata -- Cognitive behavior therapy / Ellen Flannery-Schroeder and Alexis N. Lamb -- Parent-training interventions / Nicholas Long, Mark C. Edwards, and Jayne Bellando -- Conduct disorders / Christopher T. Barry ... [et al.] -- Treatment of Attention-deficit/hyperactivity disorder (ADHD) / Ditza Zachor, Bart Hodgens, and Cryshelle Patterson -- PTSD, anxiety, and phobia / Thompson E. Davis III -- Treatment strategies for depression in youth / Martha C. Tompson and Kathryn Dingman Boger -- Medication treatment of bipolar disorder in developmentally disabled children and adolescents / Zinoviy A. Gutkovich and Gabrielle A. Carlson -- Treatment of autism spectrum disorders / Mary Jane Weiss, Kate Fiske, and Suzannah Ferraioli -- Treatment of self-injurious behaviour in children with intellectual disabilities / Frederick Furniss and Asit B. Biswas -- Communication, language, and literacy learning in children with developmental disabilities / Erna Alant, Kitty Uys, and Kerstin Tönsing -- Eating disorders / David H. Gleaves, Janet D. Latner, and Suman Ambwani -- Treatment of pediatric feeding disorders / Cathleen C. Piazza, Henry S. Roane, and Heather J. Kadey.
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  • Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
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  • "This indispensable manual presents the Maudsley method, the leading family-based treatment for adolescents with anorexia nervosa (AN). What sets this approach apart is the central role played by parents throughout treatment. The authors are prominent experts who describe how to mobilize families to promote the patient's weight restoration and healthy eating, improve parent-child relationships, and get adolescent development back on track. Each phase of therapy is described in session-by-session detail. In-depth case illustrations show how to engage clients while flexibly implementing the validated treatment procedures"-- Provided by publisher.
  • OBJECTIVES: There are two generally accepted strategies for managing atrial fibrillation (AF): rate control and rhythm control. However, within each strategic approach there are a large number of potential pharmacological and nonpharmacological therapies, and the comparative safety and effectiveness of these therapies--both within and between strategies--are uncertain. DATA SOURCES: We searched PubMed(r), Embase(r), and the Cochrane Database of Systematic Reviews for relevant English-language comparative studies. REVIEW METHODS: Two investigators screened each abstract and full-text article for inclusion, abstracted data, rated quality and applicability, and graded evidence. When possible, random-effects models were used to compute summary estimates of effects. RESULTS: Our review included 182 articles (148 unique studies): 14 studies relevant to rate-control drugs, 3 relevant to strict versus lenient rate control, 6 relevant to rate-control procedures versus drugs in patients for whom initial pharmacotherapy was ineffective, 42 relevant to antiarrhythmic drugs and electrical cardioversion for conversion to sinus rhythm, 83 relevant to rhythm-control procedures and drugs for maintenance of sinus rhythm, and 14 focusing on the comparison of rate- and rhythm-control strategies. Our ability to draw conclusions for the Key Questions addressing rate-control strategies was limited by the small number of available studies that assessed comparable therapies and outcomes, although we found a high strength of evidence for consistent benefit of calcium channel blockers (verapamil or diltiazem) compared with digoxin for ventricular rate control. For comparisons of methods for electrical cardioversion for conversion to sinus rhythm, there was high strength of evidence that use of a single biphasic waveform was more effective than use of a single monophasic waveform (odds ratio [OR] 4.39; 95% confidence interval [CI], 2.84 to 6.78) and that a 200 Joules (J) biphasic shock was less effective than a 360 J monophasic shock (OR 0.16; 95% CI, 0.05 to 0.53). Drug enhancement of external electrical cardioversion demonstrated a benefit compared with no drug enhancement (moderate strength of evidence), but data evaluating whether any one antiarrhythmic agent was more effective than others at restoring sinus rhythm were inconclusive. Our review found high strength of evidence supporting pulmonary vein isolation (PVI) versus antiarrhythmic drugs for maintenance of sinus rhythm in a select subset of patients (those with paroxysmal AF who were younger and with no more than mild structural heart disease; OR 6.51; 95% CI, 3.22 to 13.16) and moderate strength of evidence for adding a surgical Maze procedure at the time of other cardiac surgery (specifically mitral valve surgery) as opposed to mitral valve surgery alone (OR 5.80; 95% CI, 1.79 to 18.81). Comparing rate- and rhythm-control strategies, there was moderate strength of evidence supporting comparable efficacy with regard to all-cause mortality (OR 1.34; 95% CI, 0.89 to 2.02); cardiovascular mortality (OR 0.96; 95% CI, 0.77 to 1.20); stroke (OR 0.99; 95% CI, 0.76 to 1.30); and bleeding events (OR 1.10; 95% CI, 0.87 to 1.38). Cardiovascular hospitalizations were lower with rate-control strategies than with rhythm-control strategies (OR 0.25; 95% CI, 0.14 to 0.43; high strength of evidence). We were unable to conclude whether treatment effects varied by patient characteristics due to the paucity of studies that focused on specific patient subgroups. CONCLUSIONS: In assessing clinical outcomes associated with rate- versus rhythm-control strategies, our review of recent evidence agrees with prior reviews demonstrating little overall difference in outcomes between these two strategic approaches. Uncertainties still exist within specific subgroups of interest, among the wide variety of pharmacological and procedural therapies within each strategic approach, and in the impact of strategies on long-term clinical outcomes. Specifically, our review highlights the need for additional studies evaluating final outcomes such as mortality, stroke, and cardiovascular hospitalizations.
  • Treatment of Benign Prostatic Hyperplasia: Modern Techniques is an up-to-date review of modern techniques used to treat benign prostatic hyperplasia. It provides a comprehensive review of both office and operating room based techniques. Both electrosurgical and laser based techniques are covered.These include high powered 532 nm laser photoselective laser vaporization of the prostate (PVP), holmium laser enucleation/ablation of the prostate (HoLEP/HoLAP), and Bipolar Electrovaporization of the Prostate (Bipolar EVP/Bipolar TURP). In addition, a comprehensive review of office based techniques and future therapies currently being developed is presented. Each of these techniques are presented in a balanced fashion with a focus on modern literature. Treatment of Benign Prostatic Hyperplasia: Modern Techniques will be of great value to Urologists, Urology Residents, Iternists, and Family Practitioners.
  • 1. Pain as a Perceptual Experience -- 2. Neuroplasticity, Sensitization, and Pain -- 3. Muscle Pain Treatment -- 4. Addictive Disorders and Pain -- 5. The "Five-Minute" Mental Status Examination of Persons with Pain -- 6. The Psychological Assessment of Patients with Chronic Pain -- 7. Psychological Therapies -- 8. Billing Psychological Services for Patients with Chronic Pain -- 9. Hypnosis and Pain Control -- 10. Acupuncture -- 11. Manual Therapies -- 12. Treatment of Chronic Painful Musculoskeletal Injuries and Diseases with Regenerative Injection Therapy (RIT): Regenerative Injection Therapy Principles and Practice -- 13. Interdisciplinary Functional Restoration and Pain Programs -- 14. Pain and Spirituality -- 15. Pain Disparity: Assessment and Traditional Medicine -- 16. Sleep and Chronic Pain -- 17. Empowerment: A Pain Caregiver?s Perspective -- 18. Patient and Caregiver?s Perspective -- 19. Pain Medicine in Older Adults: How Should It Differ? -- 20. Pain Medicine and Primary Care: The Evolution of a Population-Based Approach to Chronic Pain as a Public Health Problem -- 21. Pain Care Beyond the Medical Practice Office: Utilizing Patient Advocacy, Education, and Support Organizations -- 22. Neonatal Pain -- 23. Assessing Disability in the Pain Patient -- 24. The Double Effect: In Theory and in Practice -- 25. Failure to Treat Pain.
  • 1. A Survey of Systems Involved in Nociceptive Processing -- 2. Pharmacogenomics of Pain Management -- 3. Nonsteroidal Anti-inflammatory Drugs -- 4. The Role of Antidepressants in the Treatment of Chronic Pain -- 5. Anticonvulsant Medications for Treatment of Neuropathic and "Functional" Pain -- 6. NMDA Receptor Antagonists in the Treatment of Pain -- 7. Role of Muscle Relaxants in the Treatment of Pain -- 8. Topical Analgesics -- 9. Sleep Aids -- 10. Clinical Use of Opioids -- 11. Opioid Adverse Effects and Opioid-Induced Hypogonadism -- 12. Acute Management of the Opioid-Dependent Patient -- 13. Opioids and the Law -- 14. Methadone for Chronic Pain -- 15. Toxicology Screening for Opioids -- 16. Monitoring Drug Use and Abuse: The Evolution of a Paradigm -- 17. Polypharmacy and Drug Interaction -- 18. Role of Cannabinoids in Pain Management -- 19. The Future of Pain Pharmacotherapy.
  • Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.
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    v. 1. Worldwide evidence 1985-1990.
  • I. Bridging the Gap : The Overview -- -- A perfect biopsychosocial storm : gender, culture, and eating disorders / Margo Maine and Douglas W. Bunnell -- What's weight go to do with it? Weight neutrality in the health at every size paradigm and its implications for clinical practice / Deborah Burgard -- Neuroscience : contributions to the understanding and treatment of eating disorders / Francine Lapides -- Are media an important medium for clinicians? Mass media, eating disorders, and the bolder model of treatment, prevention, and advocacy / Michael P. Levine -- -- II. Bridging the Gap : Diagnosis and Treatment -- -- The assessment process : refining the clinical evaluation of patients with eating disorders / Drew A. Anderson, Jackson M. Lavender, and Kyle P. De Young -- Medical assessment of eating disorders / Edward P. Tyson -- Psychiatric medication : management, myths, and mistakes / Martha M. Peaslee Levine and Richard L. Levine -- Nutritional impact on the recovery process / Jillian K. Croll -- Science or art? Integrating symptom management into psychodynamic treatment of eating disorders / Nancy L. Cloak and Pauline S. Powers -- New pathways : applying acceptance and commitment therapy to the treatment of eating disorders / Kathy Kater -- Outpatient treatment of anorexia nervosa following weight restoration : practical and conceptual issues / Richard A. Gordon -- Recipe for recovery : necessary ingredients for the client's and clinician's success / Beth Hartman McGilley and Jacqueline K. Szablewski -- -- III. Bridging the Gap : Special Populations -- -- Borderline personlity and eating disorders : a chaotic crossroads / Randy A. Sansone and Lori A. Sansone -- Managing the eating disorder patient with a comorbid substance use disorder / Amy Baker Dennis and Bethany L. Helfman -- Comorbid trauma and eating disorders : treatment considerations and recommendations for a vulnerable population / Diann M. Ackard and Timothy D. Brewster -- Healing self-inflicted violence in adolescents with eating disorders : a unified treatment approach / Kimberly Dennis and Jancey Wickstrom -- The weight-bearing years : eating disorders and body image despair in adult women / Margo Maine -- Men with eating disorders : the art and science of treatment engagement / Douglas W. Bunnell IV. Bridging the Gap : Family Issues -- -- Mutuality and motivation in the treatiment of eating disorders : connecting with patients and families for change / Mary Tantillo and Jennifer Sanftner -- When helping hurts : the role of the family and significant others in the treatment of eating disorders / Judith Brisman -- The most painful gaps : family perspectives on the treatment of eating disorders / Robbie Munn ... [et al.] -- -- V. Bridging the Gap : Mind, Body, and Spirit -- -- The role of spirituality in eating disorder treatment and recovery / Michael E. Berrett, Randy K. Hardman and P. Scott Richards -- The case for integrating mindfulness in the treatment of eating disorders / Kimberli McCallum -- The use of holistic methods to integrate the shattered self / Adrienne Ressler, Susan Kleinman and Elisa Mott -- Incorporating exercise into eating disorder treatment and recovery : cultivating a mindful approach / Rachel M. Calogero and Kelly N. Pedrotty-Stump -- Body talk : the use of metaphor and storytelling in body image treatment / Anita Johnston -- -- VI. Bridging the Gap : Future Direction -- -- The research/practice gap : challenges and opportunities for the eating disorder treatment professional / Judith D. Banker and Kelly L. Klump.
  • 1. Anatomy and Biomechanics of the Elbow / A. Celli -- 2. The Clinical Examination of the Elbow / A. Hinssche, D. Stanley -- 3. Imaging of the Elbow / V. Spina, L. Baldini -- 4. Elbow Surgical Approaches / A. Celli, L. Celli -- 5. The Treatment of Distal Humerus Fractures / S.W. O'Driscoll -- 6. The Fractures of the Olecranon / J.E. Adams, S.P. Steinmann -- 7. The Radial Head Fractures / M.W. Hartman, S.P. Steinmann -- 8. The Treatment of Coronoid Fractures and their Complications / A.G. Schneeberger -- 9. Lateral Collateral Ligament Injury / D. Stanley -- 10. The Complex Dislocations of the Elbow / G.J.W. King -- 11. The Fracture-Dislocation of the Forearm (Monteggia and Essex-Lopresti Lesions) / A. Celli, M.C. Marongiu, M. Fontana, L. Celli -- 12. The Instability after Radial Head Excision / S.L. Jensen -- 13. The Radial Head Prosthesis: Historical Perspective / C. Rovesta, C. Minervini, G. Bonanno, L. Celli -- 14. The Swanson Radial Head Prosthesis / B. Martinelli -- 15. Bipolar Radial Head Prosthesis / A. Celli -- 16. Evolve Modular Metallic Radial Head Arthroplasty / G.J.W. King -- 17. Radial Head Prosthetic Replacement with the Avanta Implant / B.F. Morrey -- 18. Radial Head Replacement with a Pyrocarbon Head Prothesis: Preliminary Results of a Multicentric Prospective Study / Y. Allieu, M. Winter, J.P. Pequignot, P. De Mourgues -- 19. Elbow Stiffness / A. Celli, L. Celli -- 20. The Arthroscopic Treatment of the Stiff Elbow / S.W. O'Driscoll -- 21. The Surgery of Neglected Distal Humerus Fractures in Children and Adults / L.P. Müller, M. Hansen, B.F. Morrey, K.J. Prommersberger, P.M. Rommens -- 22. Total Elbow Replacement for Rheumatoid Arthritis / B.F. Morrey -- 23. Total Elbow Arthroplasty in Acute Fracture / A. Celli -- 24. Latitude Convertible Total Elbow Prosthesis / G.J.W. King, K. Yamaguchi, S.W. O'Driscoll -- 25. Total Elbow Arthroplasty for Post-traumatic Arthrosis / A.G. Schneeberger, B.F. Morrey -- 26. Revision of Failed Elbow Arthroplasty / B.F. Morrey -- 27. Elbow Nerve Tunnel Syndromes / A. Celli, C. Rovesta, M.C. Marongiu -- 28. Traumatic Isolated Lesions of Musculocutaneous Nerve / C. Rovesta, M.C. Marongiu, G. Bonanno, A. Celli, L. Celli -- 29. The Traumatic Nerve-Vascular Lesions / R. Adani, G. Leo, L. Tarallo -- 30. The Utility of Continuous Axial Brachial Plexus Catheters after Surgery / F. Gazzotti, L.V. Indrizzi, G. Magni, E. Bertellini, A. Tassi -- 31. Elbow Brace in Physical Therapy / R. Rotini, A. Marinelli.
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  • This book intensively examines the efficacy of plant-derived products that have been used for over a thousand years by practitioners of so-called Traditional Chinese Medicine in the light of recent chemotherapeuticals. The chapters were written by renowned Chinese medical researchers and are supplemented by results obtained in German antiparasitic research projects. Parasites and emerging diseases are a major threat of our time, which is characterized by an enormous increase in the size of the human population and by an unbelievably rapid globalization that has led to the daily transport of millions of humans and containers with goods from one end of the earth to the other. Furthermore the slow but constant global warming offers new opportunities for many agents of diseases to become established in new areas. Therefore it is essential that we develop precautions in order to avoid epidemics or even pandemics in overcrowded megacities or at the large-scale farm animal confinements that are needed to secure a steady flow of food in the crowded regions of the world. Of course intensive research in the field of chemotherapy since 1900 has produced unbelievable breakthroughs in therapies for formerly untreatable and thus deadly diseases. However, a large number of untreatable diseases remain, as well as a constantly growing number of agents of disease that have developed resistances to standard chemical compounds.
  • Venous anatomy, physiology and pathophysiology -- Presentations of venous disease -- Patient evaluation: history and physical examination -- Lower extremity ultrasound: diagnostic and therapeutic applications -- Overview of therapy for leg veins -- Sclerotherapy -- Laser surgery -- Ambulatory phlebectomy -- Endovenous thermal ablation -- Venous stripping and subfascial endoscopic perforator surgery (SEPS) -- Indications for surgery today: an historic review of varicose vein treatment -- Compression therapy.
  • Lung cancer is the leading cause of cancer death in both men and women in the United States, and male Veterans seeking care at VA hospitals have a much higher age-specific incidence of lung cancer than males in the general population. The personal and economic significance of lung cancer has led to a vast research endeavor to try and identify new and more effective treatments. Most patients with lung cancer are diagnosed when the cancer is already advanced (stage IIIB or IV), and they are no longer candidates for surgical resection. Small cell lung cancer and non-small cell lung cancer (NSCLC) are different diseases in terms of treatment. Until recently, all therapies for advanced NSCLC were based on their cytotoxic properties. In the last few years, several novel agents aimed at specific molecular targets have been developed. This review was requested to evaluate the current evidence on the effectiveness and cost-effectiveness of treatments for advanced lung cancer.
  • This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authorsℓ́ℓ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.
  • Any surgical intervention, elective or acute, may lead to postoperative complications. Moreover, the pertaining approach - laparoscopic or open - will probably not differ in the morbidity rate after surgery. Complications that occur after a surgical intervention can be classified as major or minor. Major complications to the digestive tract after surgery imply in most of cases a leakage of an anastomosis, bleeding in the abdominal cavity or in the tract, the appearance of intraperitoneal abscesses, or surgical site infections and wound dehiscence. These complications, depending on the organ affected, upper GI, HPB tract or colorectal, are associated with high morbidity and mortality. Early suspicion and diagnosis, followed by an early and effective treatment is imperative in order to reduce the morbidity and mortality. Adequate treatment will involve a good coordination of the three disciplines involved in treatment: the surgeon, the intervention radiologist, and the gastroenterologist. Approach of these postoperative complications is changing constantly and these changes are not properly known by general and more specialized digestive surgeons daily involved in the treatment of these diseases. The proposal for this book is to offer a systematic description of the most frequent complications occurring in the three above mentioned parts of the digestive tract. In this way, the reader will have access to a practical book in which every current complication can be easily recognized, along with relevant information as guide for an adequate treatment.
  • 1. The pathophysiology, presentation and diagnostic investigation of pulmonary hypertension -- 2. Molecular biological aspects, therapeutic targets and new treatment strategies -- 3. Current treatment strategies, guidelines and new therapies -- 4. The role of surgery in pulmonary hypertension -- 5. Putting it all together -- Index.
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  • Treatment of Skin Disease is your definitive source for managing the complete range of dermatologic conditions you're likely to encounter in practice. This medical reference book boasts an intuitive and easy to use format that covers the full spectrum of options, equipping you with not only standard treatment strategies, but second- and third-line therapies for instances when other alternatives fail. You'll be thoroughly prepared to offer your patients the expertly informed medical care they deserve when facing common or complex dermatologic diseases. Address your most difficult clinical challenges by having every possible therapy option at your disposal, including third- and fourth-line therapies, as well as standard treatments for dermatologic disorders. Apply the in-depth knowledge of leading dermatologists through a summary of each treatment strategy along with detailed discussions of treatment choices. Gain insight to the essential features which define each dermatologic disease with chapters presented in a tabular format, using checklists of diagnostic and investigative pearls and color-coded boxed text, for quick at-a-glance summaries of key details. Seamlessly search the full text and access the Gold Standard drug database online at Expert Consult.
  • This is a timely and informative updated volume for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, Treatment of the Obese Patient, Second Edition is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current treatment issues and strategies for both adults and children. An essential, practical text that sorts, synthesizes, and interprets the latest information on obesity-related topics, Treatment of the Obese Patient, Second Edition, is an essential resource for clinical endocrinologists and other health care providers across a broad spectrum of specialties.
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  • Creating clinical guidelines is a modern trend. Published studies pertaining to a given theme are collected, their credibility evaluated, and then treatment options in the form of evidence-based guidelines are offered. There are a number of guidelines for the treatment of thyroid tumors that have established positions in clinical practice in North America and in Western European countries. In Japan, however, where radioisotope facilities are of limited availability, treatment plans for differentiated thyroid cancer differ considerably from those of America and Europe, and the associated clinical guidelines need modification before they can be adopted. In addition, although thyroid tumor is a common disease in endocrine practice, its management can differ even among specialists. Thus, a Japanese clinical guideline for the treatment of thyroid tumor was desired by many clinicians. As a combination of evidence-based and consensus-based guidelines for the treatment of thyroid tumor, this book offers alternatives to conventional approaches in the West. Ultimately, the authors hope the guideline will lead to the best possible treatment for patients all over the world in the not-distant future.
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  • Section I: Land of Opportunity -- The health care landscape -- Introduction -- Person-centered care -- Whole health -- Shared decision making -- Wagner care model -- Health care reform -- Medical necessity -- Integrated care -- Workforce changes -- Trauma-informed care -- DSM-5TM -- Ready to go -- Section II: Getting Started -- Assessment -- Stating the case -- Creating the solution -- Making it happen -- Understanding needs: the integrated summary -- Stating the case -- Creating the solution -- Making it happen -- Section III: On the Road -- Setting goals -- Stating the case -- Creating the solution -- Making it happen -- Focusing on change: identifying barriers and specifying objectives -- Stating the case -- Creating the solution -- Making it happen -- Interventions -- Stating the case -- Creating the solution -- Making it happen -- Journey's End: The Destination -- Evaluating the process -- Stating the case -- Creating the solution -- Making it happen.
  • This book provides essential knowledge for creating treatment plans for adult dental patients. Treatment planning strategies are presented to help with balancing the ideal with the practical, with emphasis placed on the central role of the patient -- whose needs should drive the treatment planning process. The focus is on planning of treatment, not on the comprehensive details of every treatment modality in dentistry. CD-ROM bound into book presents five cases of varying difficulty with interactive exercises that allow users to plan treatment. What's the Evidence? boxes link clinical decision-making and treatment planning strategies to current research. In Clinical Practice boxes highlight specific clinical situations faced by the general dentist. Review Questions and Suggested Projects, located at the end of each chapter, summarize and reinforce important concepts presented in the book. Key Terms and Glossary highlights the terms that are most important to the reader. Suggested Readings lists included at the end of most chapters provide supplemental resources.
  • "With the advent of computer technology and medical imaging, treatment planning in radiation oncology has evolved from a way of devising beam arrangements to a sophisticated process whereby imaging scanners are used to define target volume, simulators are used to outline treatment volume, and computers are used to select optimal beam arrangements for treatment. As such, this book is designed to provide a comprehensive discussion of the clinical, physical, and technical aspects of treatment planning. The intent of Treatment Planning in Radiation Oncology is to review these methodologies and present a contemporary version of the treatment planning process"--Provided by publisher.
  • "Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia."--Publisher's website.
  • Written to address conditions specifically associated with ethnic disparities in skin types, by Susan C. Taylor, Sonia Badreshia, Valerie D. Callender, Raechele Cochran Gathers and David A. Rodriguez , MD, helps you effectively diagnose and treat a wide-range of skin conditions found in non-white patients. Presented in an easy-to-use, templated format, this new reference encompasses medical dermatology and cosmetic procedures and provides you with evidence-based first and second line treatment options. Practical tips and other highlighted considerations minimize the risk of potential pitfalls. A dedicated section examines alternative therapies, some of which have cultural significance and may impact medical outcomes. An abundance of vivid color images and photos provide unmatched visual guidance for accurate diagnosis and treatment.
  • Anatomical overview of the central and peripheral nervous system -- Physiology of the nervous system -- Characterization of tremor -- Principal disorders associated with tremor -- Quantification of tremor -- Mechanisms of tremor -- Treatments.
  • From Darwin and Metchnikoff to Burnet and beyond / Cooper, E.L. -- General introduction to innate immunity: Dr. Jekyl/Mr. Hyde quality of the innate immune system / Zonker, K.S. -- The innate immune system of mammals and insects / Müller, U. ... [et al.] -- Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands / Areschoug, T., Gordon, S. -- Antimicrobial peptides in innate immune responses / Sorensen, O.E., Borregaard, N., Cole, A.M. -- Complement: an efficient sword of innate immunity / Rambach, G., Würzner, R., Speth, C. -- Antibacterial chemokines: actors in both innate and adaptive immunity / Eliasson, M., Egesten, A. -- The role of neutrophils and monocytes in innate immunity / Kantari, C., Pederzoli-Ribeil, M., Witko-Sarsat, V. -- Innate immune functions of the airway epithelium / Bartlett, J.A., Fischer, A.J., McCray, Jr, P.B. -- Oxidative innate immune defenses by Nox/Duox family NADPH oxidases / Rada, B., Leto, T.L. -- Aging and impairment of innate immunity / Nomellini, V., Gomez, C.R., Kovacs, E.J.
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  • This book covers topical issues in neurovascular surgery, and in particular the management of intracranial aneurysms, arteriovenous malformations, and cavernomas, current trends in cerebral revascularization, and new concepts in cerebrovascular imaging. The contents reflect the continuing developments in interventions in cerebrovascular disorders as a result of progress in neuroimaging, evolution of pathophysiological concepts, new clinical trials, and technological innovations. The chapters are all written by acknowledged experts from across the world, and comprise original papers presented at the 6th European Japanese Stroke Surgery Conference, held in June 2012 in Utrecht, The Netherlands. The book will be of value to all who are interested in the latest developments in the field and offers fascinating insights into varied perspectives and techniques.
  • Endoscopic Intra-Hematomal Evacuation of Intracerebral Hematomas - A Suitable Technique for Patients with Coagulopathies -- The Prediction of 30-Day Mortality and Functional Outcome in Spontaneous Intracerebral Hemorrhage with Secondary Ventricular Hemorrhage: A Score Comparison -- Characteristics of Carotid Plaque Findings on Ultrasonography and Black Blood Magnetic Resonance Imaging in Comparison with Pathological Findings -- Indication for Surgical Treatment of Carotid Arterial Stenosis in High-Risk Patients -- The Impact of Early Perfusion CT Measurement After Extracranial-Intracranial Bypass Surgery: Results of a Pilot Study -- Genetic and Clinical Characteristics of Moyamoya Disease in Europeans -- Effect of Mouth Opening on Bypass Function After Combined Revascularization for Moyamoya Disease -- Revascularisation Surgery and Long-Term Follow-up in Juvenile Moyamoya Syndrome: A Retrospective Analysis -- Tissue Fusion, a New Opportunity for Sutureless Bypass Surgery -- STA-MCA Bypass for the Treatment of Ischemic Stroke -- The New MRI Modalities "BPAS and VISTA" for the Diagnosis of VA Dissection -- Intracranial Stenting in Arterial Occlusive Disease -- A View on the Current and Future Therapy of Brain Aneurysms -- Surgical Treatment for Aneurysms in the Cavernous - Petrous Portion of the Internal Carotid Artery -- Aneurysms of the Posterior Cerebral Artery and Approach Selection in Their Microsurgical Treatment: Emphasis on the Approaches: SAHEA and SCTTA -- Neck Clipping of Paraclinoid Small Aneurysms -- Deferoxamine Reduces Early Brain Injury Following Subarachnoid Hemorrhage -- Does Magnetic Resonance Imaging Produce Further Benefit for Detecting a Bleeding Source in Subarachnoid Hemorrhage of Unknown Origin? -- Treatment of Experimental Cerebral Vasospasm by Protein Transduction of Heme Oxygenase 1 (HO-1) Conjugated to a Residue of 11 Arginines -- Training Models for Vascular Microneurosurgery -- How to Deal with Incompletely Treated AVMs: Experience of 67 Cases and Review of the Literature -- Clinical Relevance of Associated Aneurysms with Arteriovenous Malformations of the Posterior Fossa.
  • Part I. Molecular bases for stem and cancer cells proliferation -- An introduction to proliferation and migration of stem cells and cancer -- the role of cell adhesions, cell junctions and extracellular matrix in normal development and carcinogenesis -- The embryonic rest hypothesis of cancer development: 150 years later -- Are calcium channels more important than calcium influx for cell proliferation?- Role of calcium signaling in stem cells and cancer cells proliferation -- Formation and function of lipid droplets in inflammation and cancer -- The role of sphingolipids in modulating pluripotency of stem cells -- Part II. Signaling pathways to cancer cells fate -- Signaling pathways of cbl-b and its role on peripheral t cell tolerance -- Bh3-only proteins in cancer and apoptosis -- Signaling pathways of mta family proteins as regulators of cancer progression and metastasis -- Signalling pathways of [beta]-catenin/jnk on carcinogenesis -- The regulation of the jnk cascade and programmed cell death by nf- b: mechanisms and functions -- Part III. Uncontrolled physiology process guiding to cancer cells -- Migration, metastasis and more: the role of chemokines in the proliferation, spreading and metastasis of tumors -- Autophagy, cell death, and cancer -- The duality of stem cells: double edged sword in tumour evolution and treatment -- Glioblastoma stem cells and implications for chemoresistance -- The tumor microenvironment as a transient niche: a modulator of epigenetic states and stem cell functions -- Tumor-associated neutrophils (tans) -- Microrna control of apoptotic programs in cancer -- Part IV. Therapeutic strategies for anticancer treatment -- Markers of cancer stem cells and their functions -- Cancer cell dormancy: potential therapeutic targets to eradicate cancer cells within the niche -- Modulating apoptosis in cancer therapy with ultrasound and high intensity nanosecond electric pulses -- Targeting cell cycle for anticancer treatment and neuroprotection.
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  • Wear and osteolysis are still the most important potential problems in total hip and knee arthroplasty. Although technology in arthroplasty has been improved dramatically during the past decade, the clinical data relating to some implants reveal that many concerns remain. During the "Tribology Day" within the scientific programme of the 2013 EFORT Congress in Istanbul, the main topics included these concerns as well as the benefits of the materials most commonly used in total hip and knee arthroplasty. This book includes the presentations delivered on the day and covers a range of interesting issues regarding metal, ceramic, and polyethylene articulations. It provides information on the current concepts relating to tribology in total hip arthroplasty and offers a critical outlook on possible improvements in total knee arthroplasty.
  • This book is devoted solely to the tricuspid valve and its role in congenital heart disease. Tricuspid valve anomalies are part of the pathological spectrum in various congenital heart diseases, including Ebstein anomaly and tricuspid valve dysplasia, with different pathophysiology and clinical implications. This book covers all relevant aspects of such anomalies, including diagnosis, therapy, and follow-up. Further topics addressed include the way in which the tricuspid valve may become the 'systemic' valve in some congenital diseases, with important consequences, and the involvement of the tricuspid valve in the right-sided heart complications often seen in adults with congenital heart disease. All of the chapters are written by internationally recognized experts and are designed to deliver state of the art knowledge of practical value. This book will be an important addition to the library for surgeons, cardiologists, and other practitioners involved in the management of patients with congenital heart disease.
  • Historical Perspectives on Trigeminal Nerve Injuries -- Classification of Nerve Injuries -- Etiology and Prevention of Nerve Injuries -- Injection Injuries of the Trigeminal Nerve -- Third Molar Injuries of the Trigeminal Nerve -- Dental Implant-Related Injuries of the Trigeminal Nerve -- Nerve Repositioning Injuries of the Trigeminal Nerve -- Orthognathic Injuries of the Trigeminal Nerve -- Nerve Injury and Regeneration -- Clinical Evaluation of Nerve Injuries -- Imaging of the Trigeminal Nerve -- Nonsurgical Management of Trigeminal Nerve Injuries -- Surgical Management of Lingual Nerve Injuries -- Surgical Management of Inferior Alveolar Nerve Injuries -- Surgical Management of Facial Nerve Injuries -- Nerve Grafts and Conduits -- Complications of Trigeminal Nerve Repair -- Neurosensory Rehabilitation -- Outcomes of Trigeminal Nerve Repair -- Guidelines for Diagnosis and Treatment of Trigeminal Nerve Injuries.
  • Muscle chains / Philipp Richter: introduction -- Models of myofascial chains -- Physiology -- The craniosacral model -- The biomechanical model of John Martin Littlejohn : the mechanics of the spinal column -- Postural muscles, phasic muscles, and crossed syndrome (Vladimir Janda's contribution to myofacial treatment methods) -- Zink patterns -- Myofascial chains : a model -- Posture -- Diagnosis -- Therapy -- Trigger points and their treatment / Eric hebgen: Definition -- Classification of trigger points -- Pathophysiology of trigger points -- Diagnosis -- Trigger point therapy -- Trigger point-sustaining factores -- The facilitated segment -- The trigger points.
  • TRIM/RBCC proteins 2012
    Genomics and evolution of the TRIM gene family / Germana Meroni -- The tripartite motif : structure and function / Lucia Micale ... [et al.] -- TRIM proteins as ring finger E3 ubiquitin ligases / Kazuhiro Ikeda and Satoshi Inoue -- PML nuclear bodies and other TRIM-defined subcellular compartments / Elizabeth C. Batty, Kirsten Jensen, and Paul S. Freemont -- TRIM involvement in transcriptional regulation / Florence Cammas ... [et al.] -- TRIM proteins in cancer / Valeria Cambiaghi ... [et al.] -- TRIM proteins and the innate immune response to viruses / Melvyn W. Yap and Jonathan P. Stoye -- The microtubule-associated C-I subfamily of TRIM proteins and the regulation of polarized cell responses / Timothy C. Cox -- MuRFS : specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism / Olga Mayans and Siegfried Labeit -- Trim proteins in development / Francesca Petrera and Germana Meroni.
  • A brief history of triplet repeat diseases -- Huntington's disease and cell therapies: Past, present, and future -- Transcranial two-photon imaging of synaptic structures in the cortex of awake head-restrained mice -- In vivo imaging of synapse plasticity in the mouse motor cortex -- Pluripotent hybrid stem cells from transgenic Huntington's disease monkey -- Mesenchymal stem cells for trinucleotide repeat disorders -- Lentiviral-mediated gene transfer of siRNAs for the treatment of Huntington's disease -- Purification of dFMR1-containing complexes using tandem affinity purification -- Combined FISH and immunofluorescent staining methods to co-localize proteins and mRNA in neurons and brain tissue -- Epigenetic modifications of the FMR1 gene -- The CGG repeat and the FMR1 gene -- Study of oxidative damage and antioxidant systems in two Huntington's disease rodent models -- Regulation of ataxin-1 phosphorylation and its impact on biology -- Towards understanding region-specificity of triplet repeat diseases: Coupled immunohistology and mass spectrometry imaging -- Antibodies and intrabodies against huntingtin: Production and screening of monoclonals and single-chain recombinant forms -- Cell recovery from DM1 transgenic mouse tissue to study (CTG) n instability and DM1 pathogenesis -- Markerless modification of trinucleotide repeat loci in BACs -- DRPLA: Recent advances in research using transgenic mouse models.
  • Triptans for migraine 2012
    Future Med
    Triptans for migraine / Hans-Christoph Diener & David W. Dodick -- Pathophysiology of migraine & triptan mechanism of action / Rashmi B. Halker & Bert B. Vargas -- Overview of oral triptans / Michail Vikelis & Alan M. Rapoport -- The non-orally administered triptans / Todd J. Schwedt -- Triptans for migraine in special populations : pediatric migraine / Paul Winner -- Migraine and triptan therapy in an aging population : weighing risks against benefits / Roger K. Cady & Kathleen Farmer -- Triptans for migraine in special populations : migraine during pregnancy and lactation / Sylvia Lucas -- Treatment recommendations & consensus guidelines / Hans-Christoph Diener & Stephen D. Silberstein -- Index.
  • Severe malaria, South African perspective / Lucille Blumberg -- Severe malaria: North American perspective / Monica E. Parise, and Linda S. Lewis -- Viruses in the intensive care unit (ICU), South African perspective / Guy A. Richards, Bunter Schleicher and Mervyn Mer -- Viral infections in ICU patients, North American perspective / David E. Greenburg, and Stephen B. Greenberg -- Tuberculosis in the intensive care unit, South African perspective / Charles Feldman -- Tuberculosis in the intensive care unit: the North American Perspective / Loren C. Denlinger, and Jeffrey Glassroth -- HIV in the ICU, South African perspective / Alan S. Karstaedt, L. Rhudo Mathivha, Christine L.N. Banage -- HIV infection and associated infections in the intensive care unit: perspectives from North America / Scott E. Evans and Andrew H. Limper -- African trypanosomiasis / Hayden T. White -- Parasitic infections in the ICU / John Frean -- Fungal infections in the ICU / Francois I. Venter and Ian Sanne -- Endemic mycosis, North American perspective / Chadi A. Hage, Kenneth S. Knox, George A. Sarosi -- Index.
  • PUBLIC HEALTH ASPECTS -- Geography and socioeconomics of the tropical areas -- Epidemiology of cancer in the tropical areas -- Management of cancers in countries with limited resources -- Access to Expensive drugs and Ethical considerations -- Precarity, social organization and outcome on cancer management in the tropical areas -- Cancer screening and prevention in the tropical areas -- Pathology and cancer research -- Cancer perception in different cultures of the tropical areas ; Cross-cultural mediation -- Cancer clinical trials in the tropical area -- BASIC SCIENCE BACKGROUND -- Spectrum of cancers due to micro-organisms (virus, bacteria, parasites) -- HIV and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the retrovirus HIV -- HTLV1 and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the retrovirus HTLV1 -- Hepatitis virus scientific background : Epidemiology and mechanism of carcinogenesis of the virus HBV -- Hepatitis virus scientific background : Epidemiology and mechanism of carcinogenesis of the virus HCV -- EBV and cancer; scientific background: Epidemiology of EBV and mechanisms of carcinogenesis -- HPV and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the virus HPV -- HHV8 and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the virus HHV8 -- Parasites and cancer: Epidemiology and mechanism of carcinogenesis of schitosoma -- Helicobacter and cancer: Epidemiology of Helicobacter Pylori and mechanisms of carcinogenesis -- HEMOPATHIES -- ATL (lymphoma et leukemia) -- Extranodal NK/T-cell lymphoma, nasal type -- High-grade lymphomas: Diffuse large B-cells lymphomas (with a special paragraph on CNS lymphomas) -- High-grade lymphomas: Burkitt lymphoma; Physiopathology and treatment of EBV associated lymphomas -- Mantle cell lymphoma -- Indolent lymphomas, follicular lymphomas, HVC associated marginal zone B-cell lymphomas and Waldenström disease -- Chronic myeloproliferative syndroms -- Myelodysplasic syndroms -- Acute leukemias -- CANCERS -- Breast cancer -- Cervix cancer -- Oesophageal cancer -- Gastric cancer -- Colorectal cancer -- Hepatocarcinoma -- Cholangiocarcinoma -- Pancreas cancer -- Lung cancer -- Head and neck cancers -- Bladder cancer -- Prostate cancer -- Renal cancer -- Cutaneous cancers (including melanoma) -- Ovarian cancer -- Endometrial cancer -- Cancer of the penis, anus and vulva -- Gestational trophoblastic tumors -- CNS tumors -- Thyroid cancer -- Uncommon cancers -- CANCER TREATMENT IN TROPICAL AREAS -- Pediatric oncology -- Geriatric oncology -- Surgery -- Radiotherapy -- Medical treatments (chemotherapy, hormone therapy, targeted drugs) -- HIV and cancer treatments -- Supportive cares -- Palliative cares.
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  • 2011 ClinicalKey
    Tropical Infectious Diseases: Principles, Pathogens and Practice, by Drs. Richard L. Guerrant, David H. Walker, and Peter F. Weller, delivers the expert, encyclopedic guidance you need to overcome the toughest clinical challenges in diagnosing and treating diseases caused by infectious agents from tropical regions. Sweeping updates to this 3rd edition include vaccines, SARS, hepatitis A-E, Crimean-Congo hemorrhagic fever virus, tick-borne encephalitis and Omsk hemorrhagic fever, human papilloma virus, and mucormycosis. New full-color images throughout allow you to more accurately view the clinical manifestations of each disease and better visualize the life cycles of infectious agents. And, full-text online access at enables you to perform quick searches and rapidly locate and download images. Definitive, state-of-the-art coverage of pathophysiology as well as clinical management makes this the reference you'll want to consult - online and in print - whenever you are confronted with tropical infections, whether familiar or unfamiliar! Obtain complete and trustworthy advice from hundreds of the leading experts on tropical diseases worldwide, including cutting-edge summaries of pathophysiology and epidemiology as well as clinical management.
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  • Tropomyosin 2008
    Introduction and historical perspective / Peter Gunning -- Structure and evolution of tropomyosin genes / Bernadette Vrhovski, Nadine Thézé, and Pierre Thiébaud -- Tropomyosin exons as models for alternative splicing / Clare Gooding and Christopher W.J. Smith -- Tropomyosin gene expression in vivo and in vitro / Galina Schevzov and Geraldine O'Neill -- Tropomyosin : function follows structure / Sarah E. Hitchcock-DeGregori -- Dimerization of tropomyosins / Mario Gimona -- Cooperative binding of tropomyosin to actin / Larry S. Tobacman -- Tropomyosin and the steric mechanism of muscle regulation / William Lehman and Roger Craig -- Role of tropomyosin in the regulation of contraction in smooth muscle / Steve Marston and M. El-Mezgueldi -- Tropomyosin as a regulator of cancer cell transformation / David M. Helfman ... [et al.] -- The role of tropomyosin in heart disease / David F. Wieczorek, Ganapathy Jagatheesan, and Sudarsan Rajan -- Tropomyosins in skeletal muscle diseases / Anthony J. Kee and Edna C. Hardeman -- Tropomyosins in human diseases : ulcerative colitis / Kiron M. Das and Manisha Bajpai -- Tropomyosin function in yeast / David Pruyne -- Isoform sorting of tropomyosins / Claire Martin and Peter Gunning -- Human tropomyosin isoforms in the regulation of cytoskeleton functions / Jim Jung ... [et al.] -- Tropomyosins regulate the impact of actin binding proteins on actin filaments / Uno Lindberg ... [et al.] -- Tropomyosin and ADF/cofilin as collaborators and competitors / Thomas B. Kuhn and James R. Bamburg -- Caldesmon and the regulation of cytoskeletal functions / C.L. Albert Wang -- Tropomyosins as discriminators of myosin function / E. Michael Ostap -- Tropomodulin/tropomyosin interactions regulate actin pointed end dynamics / Alla S. Kostyukova -- Emerging issues for tropomyosin structure, regulation, function, and pathology / Peter Gunning.
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    Ethnic symbols in conflicted times -- Eradicating a "Jewish gene": promises and pitfalls in the fight against Tay-Sachs disease -- Risky business in white America: gene therapy and other ventures in the treatment of cystic fibrosis -- A perilous lottery for the Black family: sickle cells, social justice, and the new therapeutic gamble -- Dreams amid diversity.
  • TRP channels 2011
    "Transient Receptor Potential (TRP) channels have gained a lot of popularity in recent years due to their involvement in a wide variety of cellular functions in many different systems. The purpose of this book is to provide detailed methods for the study of TRP channels. It includes expression and functional studies of TRP channels in heterologous systems as well as structural and functional studies of TRP channels. The author also explores various methods for detailed analysis of biophysical properties of TRP channels. In addition, the text covers high-throughput screening assays for TRP channels and offers novel and effective approaches to study endogenous TRP channel function in native systems"--Provided by publisher.
  • TRP channels in drug discovery v.1-2=, 2012
    Springer Protocols
    2nd ed., 2014 Springer Protocols
    V. 1. Introduction to TRPs : a quest for novel drug targets / Bernd Nilius -- TRP-mediated cytoskeletal reorganization : implications for disease and drug development / Chandan Goswami -- TRPA1 in drug discovery / Jun Chen, Steve McGaraughty, and Philip R. Kym -- Canonical transient receptor potential channel expression, regulation, and function in vascular and airway diseases / Brij B. Singh, Christina M. Pabelick, and Y.S. Prakash -- TRPM2 function and potential as a drug target / Barbara A. Miller -- Ca2+-activated monovalent cation-selective channels TRPM4 and TRPM5 / Barbara Colsoul ... [et al.] -- Emerging role of TRPM7 in the regulation of magnesium homeostasis / Vladimir Chubanov ... [et al.] -- TRPM8 channels as potential therapeutic targets for pain, analgesia, and thermoregulation / David D. McKemy -- TRPML channels in function, disease, and prospective therapies / David A. Zeevi -- TRPP signaling module : TRPP2/polycystin-1 and TRPP2/PKD1L1 / Alexis Hofherr -- TRPV1 as a polymodal sensor : potential to discover TRPV1 antagonists selective for specific activating modalities / Olivier Radresa ... [et al.] -- Nociceptive and nonnociceptive roles of TRPV3 and its "druggability" / Sungjae Yoo and Sun Wook Hwang -- TRPV4 and drug discovery / Fabien Vincent and Matthew A.J. Duncton -- TRP expression and function in the lung airways / Alexander Dietrich and Thomas Gudermann -- Hypoxia-dependent TRP channel function in pulmonary arterial smooth muscle cells / Beate Fuchs ... [et al.] -- Endotoxin-induced airway inflammation and asthma models / Zsuzsanna Helyes and Zsofia Hajna -- Enhanced cough, animal models / Raffaele Gatti ... [et al.] -- Capsaicin inhalation test in man / Eva Millqvist -- TRP channels in the genitourinary tract / Ana Charrua and Francisco Cruz -- Animal models of cystitis / Celia D. Cruz and Antonio Avelino -- Overactive bladder models / Roberto Soler ... [et al.] V. 2. TRPs to cardiovascular disease / José C. González-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon, and Mohamed Trebak -- Anemic zebrafish models of cardiomyopathy / Xiaojing Sun and Xiaolei Xu -- Methods to study the effects of TRP channel drugs on vascular endothelial cell function / Yan Ma, Yung-Wui Tjong, and Xiaoqiang Yao -- Atherosclerosis models with cell-mediated calcification / Beili Zhu -- Models of hypertension and blood pressure recording / Luciana Aparecida Campos and Ovidiu Constantin Baltatu -- Balloon injury in rats as a model for studying TRP channel contribution to vascular smooth muscle remodeling / Wei Zhang and Mohamed Trebak -- TRP channels in the brain / Antonio Reboreda -- Investigation of the possible role of TRP channels in schizophrenia / Loris A. Chahl -- Investigating diseases of dopaminergic neurons and melanocytes using zebrafish / Amanda Decker and Robert Cornell -- A practical guide to evaluating anxiety-related behavior in rodents / Caitlin J. Riebe and Carsten T. Wotjak -- Rodent models of conditioned fear: behavioral measures of fear and memory / Jennifer L. McGuire, Jennifer L. Coyner, and Luke R. Johnson -- Chick anxiety-depression screening model / Stephen W. White and Kenneth J. Sufka -- A clinically relevant thromboembolic stroke model in the aged rat / Ryan C. Turner, Alisa S. Elliott, Jason D. Huber, and Charles L. Rosen -- Use of cell-stretch system to examine the characteristics of mechanosensor channels: axonal growth/neuroregeneration studies / Koji Shibasaki -- Methods in neuronal growth cone biology / Robert J. Gasperini and Lisa Foa -- Transient receptor potential channels and pruritus / Heike Benecke, Janine Wäring, Tobias Lotts, and Sonja Ständer -- Skin sensitivity studies / Laurent Misery -- Hair follicle culture / Michael P. Philpott -- Animal models for type 1 diabetes / Anish Suri and Matteo Levisetti -- Type 2 diabetes models / Dorte X. Gram -- Using diet to induce metabolic disease in rodents / Angela M. Gajda, Michael A. Pellizzon, and Matthew R. Ricci -- Rodent models to evaluate anti-obesity drugs / Sharon C. Cheetham and Helen C. Jackson -- Experimental colitis models / Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington, and L. Ashley Blackshaw -- Tumor xenograft models to study the role of TRP channels in Tumorigenesis / V'yacheslav Lehen'kyi, Sergii Khalimonchyk, Albin Pourtier, Maylis Raphaël, and Natalia Prevarskaya -- Methods to study thermonociception in rodents / Kata Bölcskei -- Methods for the assessment of heat perception in humans / Michael F. Crutchlow and Joel D. Greenspan -- Collagen antibody-induced arthritis: a disease-relevant model for studies of persistent joint pain / Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson -- Animal models of muscular dystrophy / Yuko Iwata and Shigeo Wakabayashi -- Concluding remarks.
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  • Introduction: In the Aftermath of the So-Called Memory Wars / Robert F. Belli -- The Cognitive Neuroscience of True and False Memories / Marcia K. Johnson, Carol L. Raye, Karen J. Mitchell, and Elizabeth Ankudowich -- Towards a Cognitive and Neurobiological Model of Motivated Forgetting / Michael C. Anderson and Ean Huddleston -- Searching for Repressed Memory / Richard J. McNally -- A Theoretical Framework for Understanding Recovered Memory Experiences / Chris R. Brewin -- Cognitive Underpinnings of Recovered Memories of Childhood Abuse / Elke Geraerts -- Motivated Forgetting and Misremembering: Perspectives from Betrayal Trauma Theory / Anne P. DePrince, Laura S. Brown, Ross R. Cheit, Jennifer J. Freyd, Steven N. Gold, Kathy Pezdek, and Kathryn Quina -- Epilogue: Continuing Points of Contention on the Recovered Memory Debate / Robert F. Belli.
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  • Cell Biology for Immune Evasion: Organizing Antigenic Variation, Surfaces, Trafficking, and Cellular Structures in Trypanosoma brucei / Ka Fai Leung, Paul T. Manna, Cordula Boehm, Luke Maishman and Mark C. Field -- The Biology of Tsetse-Trypanosome Interactions / Guy Caljon, Linda De Vooght and Jan Van Den Abbeele -- Withstanding the Challenges of Host Immunity: Antigenic Variation and the Trypanosome Surface Coat / James Peter John Hall and Lindsey Plenderleith -- Bridging Innate and Adaptive Immunity in African Trypanosomiasis / John M. Mansfield, Donna M. Paulnock and Gina M. Hedberg -- Adaptive Immunity and Trypanosomiasis-Driven B-Cell Destruction / Stefan Magez and Magdalena Radwanska -- Normal Human Serum Lysis of Non-human Trypanosomes and Resistance of T. b. rhodesiense and T. b. gambiense / Paul Capewell, Caroline Clucas, William Weir, Nicola Veitch and Annette MacLeod -- Proteomics and African Trypanosomes: Shedding New Light on Host-Vector-Parasite Interactions and Impact on Control Methods / Philippe Holzmuller, Pascal Grébaut and Anne Geiger -- Diagnosis of African Trypanosomiasis / Philippe Büscher -- Progress Towards New Treatments for Human African Trypanosomiasis / Jose A. Garcia-Salcedo, Jane C. Munday, Juan D. Unciti-Broceta and Harry P. de Koning -- Animal African Trypanosomosis in Sub-Saharan Africa and Beyond African Borders / Boniface Namangala and Steven Odongo -- Trypanosoma (Duttonella) vivax and Typanosomosis in Latin America: Secadera/Huequera/Cacho Hueco / Mary Isabel Gonzatti, Bernardo González-Baradat, Pedro M. Aso and Armando Reyna-Bello.
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  • This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
  • Part I. Rationale and objectives -- Chapter 1. What, why, where and how? -- Chapter 2. Survey goal, objectives and indicators -- Part II. Design and methods -- Chapter 3. Protocol development and standard operating procedures -- Chapter 4. Case definitions and screening strategies -- Chapter 5. Sampling design -- Chapter 6. Interviews, data collection tools and informed consent -- Chapter 7. Chest radiography -- Chapter 8. Bacteriology -- Chapter 9. Repeat surveys -- Chapter 10. Ethical considerations -- Chapter 11. TB treatment, HIV testing and other critical interventions -- Chapter 12. Budgeting and financing -- Part III. Management, organization, logistics and field work -- Chapter 13. Survey organization and training -- Chapter 14. Field operations -- Chapter 15. Documents and data management -- Part IV. Analysis and reporting -- Chapter 16. Analysis and reporting.
  • TB prevention / Jean-Pierre Zellweger -- Optimal diagnosis : how early and improved diagnosis can help prevent TB transmission / Sandra Vivian Kik, Zhi Zhen Qin & Madhukar Pai -- Current transmission prevention methods : vaccination / Rosalind Rowland & Helen McShane -- Current transmission prevention methods : reducing disease spread from infected individuals / Gregory J. Fox, Guy B. Marks & Warwick J. Britton -- Special concerns for at-risk populations / Ivan Solovic & Vladimir Littva -- Prevention of TB in the presence of coinfection and comorbid conditions / Dina Nair & Soumya Swaminathan -- Public health, TB, immigration and travel challenge / Jean-Pierre Zellweger -- Ask the experts : managing TB in clinical practice and the impact on transmission / Jean-Pierre Zellweger -- Multiple choice questions : answers.
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    The global tuberculosis epidemic : scale, dynamics, and prospects for control / Christopher Dye and Philippe Glaziou -- The epidemiology of tuberculosis / Megan Murray -- Pathogenesis of tuberculosis : new insights / Nicholas A. Be, William R. Bishai, and Sanjay K. Jain -- Diagnosis of pulmonary and extrapulmonary tuberculosis / Phung K. Lam, Antonino Catanzaro, and Sharon Perry -- Treatment of tuberculosis / Philip C. Hopewell -- Tuberculosis/HIV coinfection : epidemiology, clinical aspects, and programmatic interventions / Alasdair Reid, Haileyesus Getahun, and Enrico Girardi -- Diagnosis and treatment of drug-resistant tuberculosis / Kwonjune Seung and Michael L. Rich -- Achieving higher case detection and cure rates : national programs and beyond / Knut Lönnroth ... [et al.] -- Antituberculosis drug resistance in the world : the latest information / Abigail Wright and Matteo Zignol -- Programmatic management of HIV-associated tuberculosis / Anthony D. Harries and Paul P. Nunn -- WHO's stop TB strategy : progress and prospects / Mukund Uplekar, Diana Weil, and Mario C. Raviglione -- New diagnostics for tuberculosis : status of development / Mark D. Perkins and Richard J. O'Brien -- New drugs for tuberculosis / Ann Ginsberg and Melvin Spigelman -- The future of tuberculosis vaccinology / Jelle Thole, Ruth Griffin, and Douglas Young.
  • Ptie 1. Contexte général des tumeurs rares -- ptie 2. Formes rares de tumeurs ubiquitaires et contextes rares de cancers -- ptie 3. Autres tumeurs rares par site.
  • Effect of Chemotherapy on the Tumor Microenvironment and Anti-tumor Immunity / Tarek M. Meniawy, Anna K. Nowak and Richard A. Lake -- Hyperthermia, the Tumor Microenvironment and Immunity / Stuart K. Calderwood -- Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ Tumor Vaccines / Stefan Nierkens, Martijn H. den Brok, Theo J. Ruers and Gosse J. Adema -- High Intensity Focused Ultrasound (HIFU) Ablation / Feng Wu -- The Interrelationship Between Cryoablation, the Immune Response and the Tumor Microenvironment: Stimulatory and Suppressive Effects / Michael S. Sabel -- In situ Tumor Ablation with Radiation Therapy: Its Effect on the Tumor Microenvironment and Anti-tumor Immunity / William H. McBride and Dörthe Schaue -- Tumor-Localized Insult Delivered by Photodynamic Therapy and the Breakdown of Tumor Immunotolerance / Mladen Korbelik -- In situ Ablation of Solid Tumors by Electric Forces and Its Effect on the Tumor Microenvironment and Anti-tumor Immunity / Yona Keisari and Rafi Korenstein.
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  • v.2, 2014 Springer
  • Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
  • Tumor microenvironment v. 1-, 2008-
  • This book will explore the many biological and physical aspects of the tumor microenvironment. The book will include chapters on the various cells that influence tumor growth and function as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters will describe endothelial cells and pericytes that form tumor vasculature. Insights on the role of progenitor and stem cells will be included. The contribution of the supporting stroma will be addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters will describe the influence of infiltrating cells of the immune system on tumor growth.
  • The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
  • Perspectives on the history and evolution of tumor models -- Murine L1210 and P388 leukemias -- Transplantable syngeneic rodent tumors: solid tumors in mice -- B16 murine melanoma: historical perspective on the development of a solid tumor model -- Human tumor xenograft efficacy models -- Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time -- Patient-derived tumor models and explants -- The pediatric preclinical testing program -- Imaging efficacy in tumor models -- Mammary cancer in rats -- Animal models of melanoma -- Experimental animal models for investigating renal cell carcinoma pathogenesis and preclinical therapeutic approaches -- Animal models of mesothelioma -- The use of mouse models to study leukemia/lymphoma and assess therapeutic approaches -- Spontaneous companion animal (pet) cancers -- Genetically engineered mouse models of pancreatic ductal adenocarcinoma -- Transgenic adenocarcinoma of the mouse prostate: a validated model for the identification and characterization of molecular targets and the evaluation of therapeutic agents -- The utility of transgenic mouse models for cancer prevention research -- Models for evaluation of targeted therapies of invasive and metastatic disease -- Animal models of toxicities caused by anti-neoplastic therapy -- Bone marrow as a critical normal tissue that limits drug dose/exposure in preclinical models and the clinic -- Anesthetic considerations for the study of murine tumor models -- Preclinical tumor response end points -- Tumor cell survival -- Apoptosis in vivo -- Transparent window models and intravital microscopy: imaging gene expression, physiological function and therapeutic effects in tumors.
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  • I. Investigations -- Neurophysiology / Allen E. Waziri, Derek A. Taggard and Vincent C. Traynelis -- Neuroradiology and Ultrasound / David G. Hughes and Roger A. Chisholm -- Neuropathology / Cheng-Mei Shaw and Ellsworth C. Alvord -- II. Perioperative Care -- Neuroanesthesia / Maryke A. Kraayenbrink and Gregory R. McAnulty -- Neurosurgical Intensive Care / Tessa L. Whitton and Arthur M. Lam -- III. Techniques -- Neuroendoscopy / Jonathan Punt -- Principles and Practice of Image-guided Neurosurgery / Kristian Aquilina, Philip Edwards and Anthony Strong -- Stereotactic Radiosurgery / Andras A. Kemeny, Matthias W. R. Radatz and Jeremy G. Rowe -- IV. Tumors -- Low-grade Gliomasin Adults / Henry Marsh -- Neurosurgical Management of High-grade Gliomas / Robert C. Rostomily, Alexander M. Spence and Daniel L. Silbergeld -- Sellar and Parasellar Tumors / Richard J. Stacey and Michael P. Powell -- Meningiomas / James J. Evans, Joung H. Lee, John Suh and Mladen Golubic -- Intraventricular and Pineal Region Tumors / Sandeep Kunwar, G. Evren Keles and Mitchell S. Berger -- Cerebello-pontine Angle Tumors / Peter C. Whitfield and David G. Hardy -- Skull Base Tumors / Richard S. C. Kerr and Christopher A. Milford -- Tumors: Cerebral Metastases and Lymphoma / Sepideh Amin-Hanjani and Griffith R. Harsh -- Pediatric Neuro-oncology / Kevin L. Stevenson, J. Russell Geyer and Richard G. Ellenbogen -- Management of Spinal Tumors / Karl F. Kothbauer, George I. Jallo and Fred J. Epstein -- Management of Extradural Spinal Tumors / David A. Lundin, Charlie Kuntz and Christopher I. Shaffrey.
  • Lifestyle and Medical Approaches to Cancer Prevention / Peter Greenwald, p. 1-15 -- Application of Genetics to the Prevention of Colorectal Cancer / John Hopper, p. 17-33 -- Genetics and Prevention of Oesophageal Adenocarcinoma / Rebecca Fitzgerald, p. 35-46 -- Preclinical Models Relevant to Diet, Exercise, and Cancer Risk R. James Barnard and William Aronson, p. 47-62 -- Individualizing Interventions for Cancer Prevention / Michael Pollak, p. 63-70 -- Can Animal Models Help Us Select Specific Compounds for Cancer Prevention Trials? / Ernest Hawk, Asad Umar, Ronald Lubet, Levy Kopelovich and Jaye Viner, p. 71-88 -- Problems with Using Biomarkers as Surrogate End Points for Cancer: A Cautionary Tale / Arthur Schatzkin, p. 89-98 -- Can a Marker Be a Surrogate for Development of Cancer, and Would We Know It if It Exists? / William Armstrong, Thomas Taylor and Frank Meyskens, p. 99-112 -- How Should We Move the Field of Chemopreventive Agent Development Forward in a Productive Manner? / Frank Meyskens and Eva Szabo, p. 113-124 -- The Problems with Risk Selection; Scientific and Psychosocial Aspects / Anne-Renée Hartman, p. 125-144 -- Chemoprevention of Lung Cancer / Stéphane Vignot, Jean-Philippe Spano, Sylvie Lantuejoul, Fabrice André, Thierry Le Chevalier and Jean-Charles Soria, p. 145-165 -- Anti-nicotine Vaccination: Where Are We? / T. Cerny, p. 167-175 -- Primary Prevention of Colorectal Cancer: Lifestyle, Nutrition, Exercise / María Martínez, p. 177-211 -- Chemoprevention of Colorectal Cancer: Ready for Routine Use? / Nadir Arber and Bernard Levin, p. 213-230 -- Screening of Colorectal Cancer: Progress and Problems Sidney Winawer, p. 231-244 -- The Role of Endogenous Hormones in the Etiology and Prevention of Breast Cancer: The Epidemiological Evidence / Paola Muti, p. 245-256 -- Innovative Agents in Cancer Prevention / Margaret Manson, Peter Farmer, Andreas Gescher and William Steward, p. 257-275 -- The IARC Commitment to Cancer Prevention: The Example of Papillomavirus and Cervical Cancer / Silvia Franceschi, p. 277-297 -- Health Economics in the Genomic Age / Thomas Szucs, p. 299-313 -- Screening for Cancer: Are Resources Being Used Wisely? / Robert Kaplan, p. 315-334.
  • Tumor suppressor genes
    Springer Protocols
    v. 2 Springer Protocols
    v. 1 Pathways and isolation strategies -- v. 2 Regulation, function, and medicinal application.
  • During the last 20 years, it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on 'Tumor-associated fibroblasts and their matrix' as part of the series on "Tumor-Microenvironment" is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor developmen.
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  • Cesar A. Moran and Saul Suster are internationally recognized experts in pulmonary pathology who present a coherent and consistent approach to interpretation and diagnosis. Through more than 900 stunning photographs and a consistent, user-friendly format, this resource provides quality guidance on the diagnostic problems you face in everyday practice. You'll get a host of innovative, practice-oriented features unavailable in any other text that streamline and facilitate diagnostic decision-making. Written by practitioners for practitioners, this visual resource is designed for quick and easy use.
  • Includes bibliographical references and index. Introduction -- Bone-forming tumors -- Cartilage-forming tumors -- Giant cell tumor -- Round cell tumor -- Fibrous tumors -- Fibrohistiocytic tumors -- Vascular Tumors -- Adamantinoma -- Notochordal tumors -- Leiomyosarcoma -- Adipocytic tumors -- Neurogenic tumors -- Phosphaturic mesenchymal tumor -- Metastatic carcinoma involving bone -- Tumor-like lesions and other conditions that simulate primary tumors.
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  • Vol. 1. Gliomas: Glioblastoma (part 1) -- Vol. 2. Gliomas: Glioblastoma (part 2) -- Vol. 3. Brain tumors (part 1) -- Vol. 4. Brain tumors (part 2) -- Vol. 5. Astrocytomas, hemangioblastomas, and gangliomas -- Vol. 6. Spinal Tumors (Part 1) -- Vol. 7. Meningiomas and Schwannomas -- Vol. 8. Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma --Vol. 9. Lymphoma, supratentorial tumors, glioneuronal tumors, gangliogliomas, neuroblastoma in adults, astrocytomas, ependymomas, hemangiomas, and craniopharygiomas -- Vol. 10. Pineal, pituitary, and spinal tumors -- Vol. 11. Pineal, pituitary and, spinal tumors -- Vol. 12. Molecular mechanisms, children's cancer, treatments, and radiosurgery -- Vol. 13. Types of tumors, diagnosis, ultrasonography, surgery, brain metastasis, and general CNS diseases -- Vol. 14. Glioma, meningioma, neuroblastoma, and spinal tumors
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  • Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research--the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.
  • Like the ten preceding volumes in the series Tumors of the Central Nervous System, this book is distinguished for its comprehensive approach, its distinguished roster of some 93 contributors representing 8 different countries and its embrace of leading-edge technology and methods. Volume 11: Pineal, Pituitary, and Spinal Tumors concentrates on the diagnosis, prognosis and therapy of four types of tumors, namely Glioblastoma, Meningioma, Schwannoma and Spinal Tumors. The book offers an in-depth survey of a range of new technologies and their applications to tumor diagnosis, treatment and therapy assessment. The contributors explain in thorough detail a range of current and newly developed imaging methods, including molecular imaging and PET scan. Also covered is molecular profiling of brain tumors to select therapy in clinical trials of brain tumors. Discussion includes a review of such surgical treatments as resection and the application of non-invasive stereotactic radiosurgery for treating high-risk patients with brain metastasis. Additional discussion is devoted to tumor seeding.
  • Classification/Diagnosis of Brain Tumors Using Discriminant Function Analysis -- Neuronal Differentiation in the Adult Brain: CDK6 as the Molecular Regulator -- Prolactinomas: Role of VEGF, FGF-2 and CD31 -- Human Brain Tumor Growth: Role of Aquaporins -- Molecular and Functional Characterization of Human Adipocytes -- Inhibition of Neuroblastoma Progression by Targeting Lymphangiogenesis: Role of an Endogenous Soluble Splice-Variant of VEGFR-2 -- Hyperinsulinemia Tends to Induce Growth Without Growth Hormone in Children with Brain Tumors After Neurosurgery -- Childhood Brain Tumours: Proton Beam Therapy -- Pathogenesis of Medulloblastoma: Role of Molecular Genetic Alterations -- Medulloblastomas: Survival Differences Between Children and Adults -- Survivors of Childhood Cancer: Risk of Glioma and Meningioma Following Radiotherapy -- Survivors of Childhood Cancer: Risk of New Primary Neoplasms of the CNS -- Brain Tumor Typing and Therapy Using Combined Ex Vivo Magnetic Resonance Spectroscopy and Molecular Genomics -- Atlas-Based Segmentation of Tumor-Bearing Brain Images -- Nonthermal Irreversible Electroporation as a Focal Ablation Treatment for Brain Cancer -- The Role of Whole Brain Radiation Therapy for Metastatic Brain Tumors -- Craniotomy for Intracranial Tumors: Role of Postoperative Hematoma in Surgical Mortality -- Pituitary Adenomas: Treatment Using the Endonasal Approach -- Intracranial Tumors: Treatment with Endoscopic Neurosurgery -- Incidence of Recraniotomy for Postoperative Infections After Surgery for Intracranial Tumors -- Transsphenoidal Surgery for Non-Adenomatous Tumors: Effect on Pituitary Function -- Treatment of Brain Tumors: Electrochemotherapy -- Comparison of Navigated Transcranial Magnetic Stimulation to Direct Electrical Stimulation for Mapping the Motor Cortex Prior to Brain Tumor Resection -- The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance -- Drugs for Primary Brain Tumors: An Update -- Neurosurgical Treatment for Brain Metastases: Clinical Features, Operative Strategies, Recurrence and Survival -- Image-Guided Radiosurgery for Hypothalamic Hamartomas -- Image-Guided Stereotactic Radiosurgery for Spinal Pathology -- Image-Guided Stereotactic Radiosurgery for Optic Nerve Sheath Meningiomas -- Brain Metastases: The Application of Stereotactic Radiosurgery and Technological Advances -- Treatment of Chordomas by Stereotactic Radiosurgery with a Linear Accelerator: Comparison with Other Modes.
  • Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.
  • v. 2, 2012 Springer
  • v. 4 Springer
  • Pt. 1. Astrocytomas : diagnosis and biomarkers -- pt. 2. Astrocytomas : therapy -- pt. 3. Astrocytomas : prognosis -- pt. 4. Hemangioblastoma -- pt. 5. Ganglioglioma.
  • This volume contains information on the diagnosis, therapy, and prognosis of spinal tumors. Various aspects of different major types of spinal tumors (astrocytomas, ependymomas, and oligodendroglioma) are discussed. Insights into the understanding of molecular pathways involved in tumor biology are explained. Classification of intradural spinal tumors, including the percentages of each of the three major types, is detailed. Symptoms, radiological features, and clinicopathological parameters of spinal cord tumors are explained. Diagnosis, outcome, and prognosis of primary spinal cord and oligodendroglioma are discussed. Diagnosis of some other spinal tumors (e.g., pilomyxoid and chordomas) is also explained. The useful role of neuroimaging in diagnosing spinal teratoid/rhabdoid and gangliogliomas is included. A wide variety of treatments of a number of spinal cord tumor types are presented in detail. Therapies discussed include chemotherapy, surgery, radiosurgery, stereotactic radiosurgery, Cyberknife stereotactic radiotherapy, standard radiation alone, and rhenium-186 intracavity radiation. Also are duiscussed embolozation and spondylectomy. The usefulness of transplantation of human embryonic stem cells-derived oligodendrocyte progenitors and motoneuron progenitors in the repair of injured spinal cord is emphasized. Symptoms of the advent of spinal tumors are pointed out. Introduction to new technologies and their applications to spinal cord tumor diagnosis, treatment, and therapy assessment are explained
  • This volume offers in-depth discussion of two types of brain tumors - meningioma and schwannoma - covering diagnosis, therapy, and prognosis. It covers molecular genetics, and such therapeutic methods as neurosurgery, gamma knife radiosurgery, and adjuvant radiation
  • With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targetedand thus more effective.
  • The ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system. This publication deals with various aspects of nine separate types of brain tumors. With 70 contributors from 17 nations, this edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research results on the following tumor types: astrocytoma, lymphoma, supratentorial and glioneuronal tumors, gangliogliomas, neuroblastoma in adults, hemangioma, and ependymoma.The content introduces new technologies and their applications
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    Normal pancreas -- Classification of pancreatic tumors -- Staging -- Serous cystic neoplasms -- Mucinous cystic neoplasms -- Intraductal neoplasms -- Ductal adenocarcinoma -- Adenocarcinoma variants -- Acinar neoplasms -- Pancreatoblastoma -- Solid-pseudopapillary neoplasms -- Endocrine neoplasms -- Nonepithelial and miscellaneous neoplasms -- Secondary neoplasms -- Non-neoplastic tumors and tumor-like lesions -- Dissection and reporting of pancreatic resection specimens -- Diagnostic evaluation of pancreatic neoplasms.
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    Specimen evaluation -- Nonmalignant fibroblastic and myofibroblastic tumors and tumor-like lesions -- Fibroblastic/myofibroblastic neoplasms with variable biologic potential -- Lipomatous tumors -- Smooth muscle tumors -- Tumors with skeletal muscle differentiation -- Vascular tumors -- Soft tissue tumors with cartilaginous or osseous differentiation -- Soft tissue tumors with epithelial differentiation -- Miscellaneous translocation sarcomas -- Miscellaneous tumors -- Cytopathology of soft tissue tumors and tumor-like lesions.
  • Tumors of the spine 2008
    Achieve optimal outcomes for your patients with this new multimedia reference. Organized by tumor then by region, this resource details diagnostic and therapeutic options for primary and malignant spinal tumors. Over 25 key procedures--including minimally invasive surgery--are presented in a concise, stepwise fashion, putting the key information you need right at your fingertips! Over 600 illustrations round out this exhaustive new reference. Keep up to date on the latest advances in diagnosis and therapy with discussions of the latest surgical techniques, including minimally invasive spine surgery. Chapter templating helps you understand the entire procedure as well as key aspects, pearls and pitfalls, before heading into the OR. Have all the information you need to make a diagnosis and plan patient management with oversized, full color clinical photos and line drawings that illustrate key diagnoses and surgical procedures.
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    Testicular tumors : general considerations -- Germ cell tumors : histogenetic considerations and intratubular germ cell neoplasia -- Germ cell tumors : seminomas -- Nonseminomatous germ cell tumors -- Mixed germ cell tumors, regressed germ cell tumors, and germ cell-sex -- Sex cord-stromal tumors -- Miscellaneous primary tumors of the testis, adnexa, and spermatic cord; hematopoietic tumors; and secondary tumors -- Tumor-like lesions.
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  • Essential cardiac anatomy and physiology as it relates to the electrocardiogram -- Electrocardiographic waveforms -- Cardiac vectors and lead systems -- Derivation of the normal electrocardiogram -- Electrical axis -- Intraventricular conduction delays: the hemiblocks -- Intraventricular conduction delays: the bundle branch blocks -- Chamber enlargement -- Myocardial infarction -- Ischemia and anginal syndromes -- The electrocardiogram and the clinical evaluation of chest pain -- The advanced cardiac life support provider and therapeutic interventions in acute myocardial infarction -- Miscellaneous conditions -- Case presentations.
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    Foundation of the Society -- The Society established and Manson's presidency, 1907-9 -- Ross's presidency: 'from a very tender plant to a very vigorous tree', 1909-11 -- The Pre-war years (1911-14) and the Royal Society of Medicine's attempt to absorb the STMH -- The Society during the Great War (1914-18) -- Early inter-war years (1919-20) -- The Society becomes Royal -- The 1920s : consolidation of the Society, but still no permanent base, and an unfortunate episode involving the Colonial Office -- George Carmichael Low's presidency and removal to Manson House, 1929-33 -- The Mid-1930s: the Society safely installed in its own house -- The Pre-World War II years -- The Society during World War II (1939-45), and the future of clinical tropical medicine -- The Early post-war years, 1946-50 -- Completion of the Society's first half-century in 1957 -- Epilogue to the Society's first half-century, 1907-57.
  • First-trimester detection of fetal anomalies -- Fetal aneuploidies -- Routine fetal anomaly scan -- Amniotic fluid -- Disorders of the placenta : localization and placental attachment disorders -- Prenatal diagnosis of fetal infections -- Fetal anomalies: the geneticist's approach -- Diagnosis of hydrops and multiple malformation syndromes -- Assessment of twin gestation -- Fetal growth -- Cranial abnormalities -- Diagnosis of spina bifida and other dysraphisms in the fetus -- Abnormalities of the face and neck -- Cardiac abnormalities and arrhythmias -- Pulmonary abnormalities -- Skeletal abnormalities -- Abdominal and abdominal wall abnormalities -- Urinary tract abnormalities -- Haematological disorders -- Fetal tumours -- Fetal magnetic resonance imaging -- Fetal pathology.
  • Two-dimensional electrophoresis : an overview / Richard Smith -- Solubilization of proteins in 2DE : an outline / Thierry Rabilloud -- Selection of pH ranges in 2DE / Mireille Starita-Geribaldi -- Difficult proteins / Ben Herbert and Elizabeth Harry -- Organelle proteomics / Matthias Plöscher ... [et al.] -- Applications of chemical tagging approaches in combination with 2DE and mass spectrometry / Alexander Leitner and Wolfgang Lindner -- Immunoblotting 2DE membranes / Brian McDonagh -- Troubleshooting image analysis in 2DE / Bettina Levänen and Åsa M. Wheelock -- Analysis of bacterial proteins by 2DE / Philip Cash and Evelyn Argo -- Proteomic analysis of Caenorhabditis elegans / Pan-Young Jeong ...[et al.] -- Protein extraction for 2DE / Claus Zabel and Joachim Klose -- Analysis of proteins from marine molluscs / Suze Chora, Maria João Bebianno, and Michèle Roméo -- Preparation and analysis of plastid proteomes by 2DE / Anne von Zychlinski and Wilhelm Gruissem -- High resolution 2DE / Katrin Marcus ...[et al.] -- Blue native-gel electrophoresis proteomics / Kelly Andringa, Adrienne King, and Shannon Bailey -- 2DE for proteome analysis of human metaphase chromosomes / Kiichi Fukui and Susumu Uchiyama -- Microsomal proteomics / Diana M. Wong and Khosrow Adeli -- Prefractionation using microscale solution IEF / Won-A Joo and David Speicher -- Diagonal electrophoresis for detection of protein disulphide bridges / Brian McDonagh -- High-resolution large-gel 2DE / Claus Zabel and Joachim Klose -- Silver staining of proteins in 2DE gels / Cécile Lelong ...[et al.] -- Detection of 4-hydroxy-2-nonenal- and 3-nitrotyrosine-modified proteins using a proteomics approach / Rukhsana Sultana, Tanea Reed, and D. Allan Butterfield -- Proteomic detection of oxidized and reduced thiol proteins in cultured cells / Sarah L. Cuddihy ...[et al.] -- Detection of ubiquitination in 2DE / Brian McDonagh -- Phosphoroproteome analysis by in-gel isoelectric focusing and tandem mass spectrometry / Sarka Beranova-Georgianni, Dominic M. Desiderio, and Francesco Giorgianni -- Detection of protein glutathionylation / Elisabetta Gianazza, Ivano Eberini, and Pietro Ghezzi -- Activity-based protein profiling of protein tyrosine phosphatases / Chad Walls, Bo Zhou, and Zhong-Yin Zhang -- Active protease mapping in 2DE gels / Zhenjun Zhao and Pamela J. Russell -- Two-dimensional difference gel electrophoresis / Gert Van den Bergh -- Protein expression profiling / Brian P. Bradley, Bose Kalampanayil, and Michael C. O'Neill -- C-terminal sequence analysis of 2DE-separated proteins / Bart Samyn, Kjell Sergeant, and Jozef Van Beeumen -- Shotgun protein analysis by liquid chromatography-tandem mass spectrometry / Kazuishi Kubota, Toshiyuki Kosaka, and Kimihisa Ichikawa --De novo sequence analysis of N-terminal sulfonated peptides after in-gel guanidination / Kjell Sergeant, Jozef Van Beeumen, and Bart Samyn -- Tryptic digestion of in-gel proteins for mass spectrometry analysis / Mai-Loan Huynh, Pamela Russell, and Bradley Walsh -- Database interrogation algorithms for identification of proteins in proteomic separations / Patricia M. Palagi, Frédérique Lisacek, and Ron D. Appel -- Creating 2DE databases for the world wide web / Christine Hoogland, Khaled Mostaguir, and Ron D. Appel.
  • Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. ...--Foreword.
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  • Two-component signaling systems. Part A-C pt. A-B, C, 2007, 2010.
    pt. B, 2007 ScienceDirect
    pt. C, 2010 ScienceDirect
    Pt. A. Computational analyses of sequences and sequence alignments ; Biochemical and genetic assays of individual components of signaling systems ; Physiological assays and readouts -- Pt. B. Structural approaches ; Reconstritution of heterogeneous systems ; Intracellular methods and assays ; Genome-wide analyses of two-component systems.
  • This book reviews current knowledge of the etiopathogenesis, pathophysiology, and molecular biology of tympanic membrane retraction pockets and provides clear guidance on clinical assessment and treatment. A new diagnostic approach based on clinicoradiologic correlations is presented, and the ability of computer tomography to offer objective criteria for improved differentiation between stable and unstable or unsafe retraction pockets is explained. Surgical options are discussed, and on the basis of their own clinical and surgical experiences the authors propose a novel procedure, masto-atticotomy with anterior epitympanotomy (AER surgery), which addresses the causative factors underlying a retraction pocket. This surgery aims to restore adequate aeration routes for the middle ear compartments situated above the tympanic diaphragm; it results in better control of the pathology and in most cases prevents its recurrence. The book will assist otologists and surgeons in ensuring that retraction pockets are effectively diagnosed and treated, avoiding progression to cholesteatoma.
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    Tympanoplasty -- Myringoplasty, meatoplasty, and canalplasty -- Ossiculoplasty -- Special applications with tympanoplasty -- Mastoidectomy and epitympanectomy -- Special applications of mastoidectomy -- Stapedotomy and stapedectomy -- Special applications of stapes surgery -- Conventional and multiplanar high-resolution computed tomography of the temporal bone -- Imaging for tympanoplasty and mastoidectomy -- Imaging for Stapes surgery -- Rules and hints -- MIcrosurgical equpiment.
  • Endocrine and Metabolic Responses to Exercise / Kostas Tsintzas and Ian A. MacDonald -- The Impact of Type 1 Diabetes on the Physiological Responses to Exercise / Michael C. Riddell Ph.D. -- Pre-exercise Insulin and Carbohydrate Strategies in the Exercising T1DM Individual / Richard M. Bracken, Daniel J. West and Stephen C. Bain -- Physical Activity in Childhood Diabetes / Krystyna A. Matyka and S. Francesca Annan -- The Role of Newer Technologies (CSII and CGM) and Novel Strategies in the Management of Type 1 Diabetes for Sport and Exercise / Alistair N. Lumb -- Hypoglycemia and Hypoglycemia Unawareness During and Following Exercise / Lisa M. Younk and Stephen N. Davis -- Fueling the Athlete with Type 1 Diabetes / Carin Hume -- Diabetes and Doping / Richard I. G. Holt -- Synthesis of Best Practice / Ian Gallen -- The Athlete's Perspective / Christopher J. Pennell, Jen Alexander, Mark S. Blewitt, Russell D. Cobb and Sebastien Sasseville, et al.
  • Epidemiology of Type 2 Diabetes -- Pathogenesis of Type 2 Diabetes Mellitus -- Metabolic mechanisms of muscle insulin resistance -- Fat metabolism in insulin resistance and Type 2 Diabetes -- Detection and diagnosis of Type 2 Diabetes - Therapies for delay or prevention of Type 2 Diabetes -- Postprandial hyperglycemia -- Medical nutrition therapy in Type 2 Diabetes -- Exercise as an effective treatment for Type 2 Diabetes -- Type 2 Diabetes Mellitus: an evidence-based approach to practical management: noninsulin pharmacological therapies -- The transition from oral agents to combination insulin/oral therapy -- Intensive insulin therapy in T2DM -- Hypoglycemia in Type 2 Diabetes -- Type 2 Diabetes and concomitant illness: the prepared practice -- Adherence to practice guidelines for people with Diabetes Mellitus -- Treatment of hypertension in Type 2 Diabetes -- Lipoproteins in Diabetes: risk and opportunity -- Management of coronary artery disease in Type 2 Diabetes Mellitus -- Peripheral vascular disease and stroke in Type 2 Diabetes -- Obesity and its treatment in Type 2 Diabetes -- The liver in Type 2 Diabetes Mellitus -- Developing criteria for defining Type 2 Diabetes in pregnancy -- Metabolic complications of polycystic ovary syndrome -- Erectile dysfunction in Diabetes -- Sexual dysfunction in women with Type 2 Diabetes -- Depression in Type 2 Diabetes -- Atypical forms in Type 2 Diabetes -- Diabetes Mellitus Type 2 and stress: pathophysiology and treatment -- Pharmacologic factors affecting glycemic control -- Influencing self-management: from compliance to collaboration.
  • Pathophysiology of type 2 diabetes -- Guidelines and classifications -- Exercise -- Nutrition -- Obesity and the metabolic syndrome -- Oral agents for type 2 diabetes -- Insulin use -- Macrovascular disease -- Microvascular disease -- Diabetic dyslipidemia -- Hypertension in diabetics -- Glycemic control -- Risk reduction in the diabetic patient.
  • Pathophysiology of type-2 diabetes -- Guidelines and classifications -- Exercise -- Nutrition -- Obesity and the metabolic syndrome -- Oral agents for type-2 diabetes -- Insulin use -- Non-insulin injectables -- Macrovascular disease -- Microvascular disease -- Diabetic dyslipidemia -- Hypertension in diabetics -- The pathophysiology and metabolic impact of hyperglycemia -- Risk reduction in the diabetic patient -- Diabetes in special populations.
  • Tyrosine kinase inhibitors for gastrointestinal stromal tumor / Peter Reichardt -- Gastrointestinal stromal tumor pathophysiology & drug targets / Eva Wardelmann -- Imatinib / Sebastian Bauer & Michael Montemurro -- Sunitinib / Wen Wen Shan & Charles D. Blanke -- Other tyrosine kinase inhibitors in clinical trials / Maria Debiec-Rychter & Sebastian Bauer -- Other tyrosine kinase inhibitors in development and future directions / Uwe Knippschild, Christian Peifer, Joachim Bischof & Klaus Kramer -- Index.
all 730 "T" titles

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available. 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Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.