BookGiorgio Iervasi, Alessandro Pingitore, A. Martin Gerdes, Salman Razvi, editors.
Summary: In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies - including multicenter studies - have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects - kidney, hormonal pathways systems, brain, muscle, etc - of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists. .
Contents:
Intro
Foreword
Foreword: Thyroid and the Heart: A Roadmap
Preface
Contents
Part I: Heart and Thyroid: Historical and Basic Aspects
1: Thyroid and the Heart: A Historical Perspective
1.1 Heart Thyrotoxicosis
1.2 Myxedema Heart
References
2: Physiological Role of Thyroid Hormone in the Developing and Mature Heart
2.1 Introduction
2.2 Membrane Transport
2.3 Metabolism
2.4 Effect of Thyroid Hormone in Heart Development
2.5 Effect of Thyroid Hormone in the Mature Heart
2.6 Conclusions
References 3: Thyroid Hormone Signaling Mechanisms in the Heart and Vasculature
3.1 TH Signaling Through Nuclear TRs
3.2 TR Isoforms
3.3 Cellular Localization of TRs
3.4 Posttranslational Modification of TRs
3.5 Genes Regulated by THs
3.5.1 Cardiomyocyte Calcium Transients and Contractility
3.5.2 Transverse-Tubules
3.5.3 Metabolism and Mitochondria
3.6 TH Signaling Through Cytosolic TRs
3.7 Vascular Responses to TH
3.7.1 Angiogenesis and Vascular Remodeling
3.8 TH Effects Independent of TRs
3.8.1 TH Activation of Ion Channels
3.9 Conclusions 5: Diastolic and Systolic Dysfunction of the Heart and Thyroid Hormone Abnormalities
5.1 Mechanism of Action of Thyroid Hormone on Myocardium
5.2 Hyperthyroidism and Cardiac Dysfunction
5.3 Effects of Overt Hypothyroidism on Cardiac Function
5.4 Action of Subclinical Hypothyroidism
5.4.1 Cardiac Function at Rest and During Exercise in Subclinical Hypothyroidism
5.4.2 Peripheral Vascular Abnormalities in Subclinical Hypothyroidism
5.5 Action of Low T3 Syndrome
5.6 Beneficial Effects of Thyroid Hormone Treatment
References Part III: Thyroid System in CV Diseases in Experimental Models
6: TH Metabolism in Ischemia/Reperfusion Models
6.1 Introduction
6.2 Overview of Thyroid Hormones and Receptors
6.3 Thyroid Hormone Metabolism
6.3.1 Deiodination Pathways
6.3.2 Alternative Pathways
6.4 Effect of TH Dysfunction on CVD and Vice Versa
6.5 Cardioprotection by TH in Ischemia: A Lesson From Experimental Models
6.6 Conclusions
References
7: Thyroid Hormone Deiodinative Pathways in the Normal and Failing Heart
7.1 Introduction