BookNadey Hakim, Mehmet Haberal, Daniel Maluf, editors.
Contents:
Intro
Foreword
Foreword
Contents
1: Organ Transplantation: A Historical Perspective
1.1 Introduction
1.2 Early History of Organ Transplantation
1.3 The Science of Immunology
1.4 The Beginning of the Modern Era of Kidney Transplantation
1.5 Renal Transplantation Between Identical Twins
1.6 Developments in Transplant Immunology
1.7 Towards Success in the Clinic
1.8 Other Early Immunosuppression Strategies: Anti-Lymphocyte Antibody Therapy
1.9 Histocompatibility Antigens, the Development of Tissue Typing, and the Advent of Organ Sharing 1.10 Advances in Organ Preservation
1.11 Early Attempts at Heart Transplantation
1.12 Brain Death
1.13 The First Attempts at Lung and Heart-Lung Transplantation
1.14 Early Attempts at Transplantation of the Liver
1.15 Early Attempts at Pancreas Transplantation
1.16 Modern Immuno suppression: Calcineurin Inhibitors
1.17 The Modern Era of Organ Transplantation
1.18 New Plastic Transplants
1.19 Xenotransplantation and Future Directions
1.20 Conclusion
1.21 Questions
References 2: Tissue Typing, Crossmatching and the Allocation of Deceased Donor Kidney Transplants
2.1 Introduction
2.1.1 Tissue Typing
2.1.1.1 Serological Tissue Typing
2.1.2 Molecular Tissue Typing
2.2 Epitopes
2.2.1 Crossmatching
2.2.1.1 The CDC Crossmatch
2.2.1.2 The Flow Crossmatch
2.2.1.3 The Virtual Crossmatch
2.2.1.4 Clinical Uses of Crossmatching
Assessing the Degree of HLA Sensitisation: Panel Reactive Antibodies
Determining the Immunological Risk of a Transplant Pairing
2.2.1.5 Cellular Crossmatching 2.2.2 Allocation of Deceased Donor Kidneys for Transplantation
2.2.2.1 Principles of Allocation: Equity and Fairness Versus Utility
2.3 Utility
2.3.1 Longevity Matching
2.3.1.1 Facilitating "Young to Young" and Avoiding "Young to Old"
2.3.1.2 Facilitating "Old to Old"
2.3.1.3 Kidney Donor Profile Index (KDPI) and Estimated Post-Transplant Survival (EPTS)
2.3.2 HLA Matching
2.4 Equity and Fairness
2.4.1 Waiting Time
2.4.2 Sensitisation
2.4.3 Prior Living Kidney Donors
2.4.4 Blood Group
2.5 Medical Urgency and Needs
2.5.1 Inadequate Dialysis 2.5.2 Paediatric Bonus
2.5.3 Changes to the Kidney Allocation System (KAS) in the United States
References
3: The Immunobiology of Transplant Rejection and Acceptance
3.1 Introduction
3.1.1 Immune Response to Transplanted Tissue
3.2 The Innate Immune System
3.3 Role of Innate Immune System in Allograft Rejection
3.4 The Adaptive Immune System
3.4.1 Cells of the Adaptive Immune System
3.4.1.1 T Cells
3.4.1.2 Helper T Cells
3.4.1.3 Type 1 Helper Cells
3.4.1.4 Type 2 Helper Cells
3.4.1.5 Cytotoxic T Cells
3.4.1.6 T Regulatory Cells
3.4.2 Role of Tregs in Experimental Allograft Tolerance.