BookYizheng Wang, editor.
Summary: "This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field"--Publisher's description.
Contents:
TRP channel classification / Hongyu Li
TRPC channel structure and properties / Shengjie Feng
TRPC channel downstream signaling cascades / Zhuohao He
TRPC channels in health and disease / Yilin Tai, Shenglian Yang, Yong Liu, Wei Shao
TRPC channels and programmed cell death / Jian Zhou, Yichang Jia
TRPC channels and stroke / Junbo Huang
TRPC channels and Alzheimer's disease / Rui Lu, Qian He, Junfeng Wang
TRPC channels and Parkinson's disease / Pramod Sukumaran, Yuyang Sun, Anne Schaar, Senthil Selvaraj, Brij B. Singh
TRPC channels and neuron development, plasticity, and activities / Yilin Tai, Yichang Jia
TRPC channels and brain inflammation / Yoshito Mizoguchi, Akira Monji
TRPC channels and epilepsy / Fang Zheng
TRPC channels and mental disorders / Karina Griesi-Oliveira, Angela May Suzuki, Alysson Renato Muotri
TRPC channels and cell proliferation / Cheng Zhan, Yu Shi
TRPC channels and glioma / Shanshan Li, Xia Ding.