BookGianni Bona, Filippo De Luca, Alice Monzani, editors.
Summary: This book covers the entire spectrum of thyroid diseases in childhood, focusing on the recent advances that have been achieved, from progress in basic science research through to novel or improved approaches to diagnosis and treatment. Introductory chapters discuss thyroid embryogenesis and the role of thyroid hormones in fetal development. The two contrasting forms of thyroid dysfunction, hypo- and hyperthyroidism, are then considered in depth, with particular attention to the molecular causes of congenital hypothyroidism. Among the other topics addressed are autoimmune thyroiditis, thyroid nodules, and pediatric neoplasms. The book concludes with an overview of promising therapeutic approaches, such as stem cell therapy. Each topic is treated by an eminent expert in the field, ensuring consistently high quality. Thyroid Diseases in Childhood will be an important source of information for endocrinologists, pediatricians, oncologists, and gynecologists, as well as other professionals interested in this topic.
Contents:
Thyroid embryogenesis
Thyroid hormones in fetal development
Etiology of congenital hypothyroidism
Neonatal screening for congenital hypothyroidism: what it has taught us about thyroid and brain
Laboratory aspects in neonatal screening of congenital hypothyroidism
Epidemiology of congenital hypothyroidism
Congenital hypothyroidism due to PAX8 mutations
Transient neonatal hypothyroidism
Central Hypothyroidism
Syndromes of resistance to thyroid hormone action
Management of congenital hypothyroidism
Neurodevelopmental outcomes in children with congenital hypothyroidism
Iodine deficiency from pregnancy to childhood
Thyroid enlargement from newborn to adolescent
Thyroid nodules and carcinoma
Autoimmune thyroiditis
Subclinical hypothyroidism
Hyperthyroidism
Generation of functional thyroid from embryonic stem cells.