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  • Book
    Peter P. Lee, Francesco M. Marincola, editors.
    Summary: This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.

    Contents:
    Preface
    Part I: Imaging of tumor microenvironment, In vivo Imaging
    New technologies to image tumors
    Part II: Immune landscapes and their biology, Systemic correlates of the tumor microenvironment
    Adaptive immunity and the tumor microenvironment
    The biology of immune active cancers and their regulatory mechanisms
    The biology of immune excluded cancers
    Immunoscore
    Part III: The tumor microenvironment and therapy, The Immune Landscape in Women Cancers
    Translational biomarkers, combination therapies and their relationship with immune landscapes
    Effects of radiation on the tumor microenvironment
    Challenges of CAR T cell therapy for solid tumors.
    Digital Access Springer 2020
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2020
    RC268.3 T86 2020
    1