Bookedited by Daniel Lafontaine and Audrey Dubé, Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.
Contents:
Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites
Screening inhibitory potential of anti-HIV RT RNA aptamers
Design and evaluation of clinically relevant SOFA-HDV ribozymes targeting HIV RNA
Directing RNase P-mediated cleavage of target mRNAs by engineered external guide sequences in cultured cells
Design and analysis of hammerhead ribozyme activity against an artificial gene target
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells
Use of tumor-targeting trans-splicing ribozyme for cancer treatment
Characterization of hairpin ribozyme reactions
Finding instances of riboswitches and ribozymes by homology search of structured RNA with infernal
Structure-based virtual screening for the identification of RNA- binding ligands
Probing riboswitch binding sites with molecular docking, focused libraries, and in-line probing assays
Discovery of small molecule modifiers of micrornas for the treatment of HCV infection
Bacterial flavin mononucleotide riboswitches as targets for flavin analogs
Construction and application of riboswitch-based sensors that detect metabolites within bacterial cells
Screening assays to identify artificial glmS ribozyme activators
Analysis of riboswitch structure and ligand binding using small-angle X-ray scattering (SAXS)
Use of SHAPE to select 2AP substitution sites for RNA-ligand interactions and dynamics studies
Cell internalization SELEX: In vitro selection for molecules that internalize into cells
DNA electronic switches based on analyte-responsive aptamers.