BookFabio Bagnoli, Rino Rappuoli, editors.
Summary: "This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab."--Back cover.
Contents:
Part I. Three dimensional human organotypic models for studying infectious diseases. Three dimensional human organotypic models for studying skin pathogens / Elena Boero, Malgorzata Ewa Mnich, Andrea Guido Oreste Manetti, Elisabetta Soldaini, Luca Grimaldi and Fabio Bagnoli
Human organotypic respiratory models / Mattias Svensson and Puran Chen
Human gastrointestinal organoid models for studying microbial disease and cancer / Jayati Chakrabarti, Martha B. Dua-Awereh, Loryn Holokai and Yana Zavros
Human organotypic models for anti-infective research / Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti and Fabio Bagnoli
Part II. Three dimensional human organotypic models for studying non-infectious diseases. Progress on reconstructed human skin models for allergy research and identifying contact sensitizers / Charlotte Rodrigues Neves and Susan GIbbs
Cancer explant models / Christian T. Stackhouse, George Yancey Gillespie and Christopher D. Willey
Organotypic models of lung cancer / Anna Pomerenke
Pancreatic cancer organotypic models / Abigail Coetzee, Richard Grose and Hemant Kocher
Breast organotypic cancer models / Pilar Carranza-Rosales, Nancy Elena Guzmán-Delgado, Irma Edith Carranza-Torres, Ezequiel Viveros-Valdez and Javier Morán-Martinez
Preclinical organotypic models for the assessment of novel cancer therapeutics and treatment / Carol Ward, James Meehan, Mark Gray, Ian H. Kunkler, Simon P. Langdon, Alan Murray and David Argyle
Overview and comparison of intestinal organotypic models, intestinal cells, and intestinal explants used for toxicity studies / Marc Maresca, Philippe Pinton, El Hassan Ajandouz, Sandrine Menard, Laurent Ferrier and Isabelle P. Oswald
Correction to: Human organotypic models for anti-infective research / Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti and Fabio Bagnoli.
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