BookMing D. Li.
Summary: This book provides the most recent knowledge on almost all key aspects of the health impact of tobacco smoking. Its 21 chapters focus on both preclinical and clinical studies. The contents are broad, covering the epidemiology of tobacco smoking; genetic epidemiology; identification of susceptibility genomic regions, genes, and pathways as determined by both human and animal studies; evolutionary relations among the different nAChR subunit genes that are so important to the nicotine response; smoking-related diseases; E-cigarettes; and smoking cessation. Furthermore, each chapter includes a detailed and comprehensive list of key references. For both clinical and basic researchers, this book is a valuable resource on nicotine dependence and other addictions.
Contents:
The Prevalence of Smoking and Its Associated Diseases
Addiction Genetics: Basic Concepts and Techniques
Estimation of Genetic and Environmental Contributions to Smoking Addiction
Identified Susceptibility Loci for Nicotine Addiction Based on Genome-Wide Linkage Analyses
Involvement of Variants in Gene Clusters CHRNA5/A3/B4 on Chromosome 15 to Smoking Behaviors and Lung Cancer
Contribution of Variants in CHRNB3/A6 Gene Cluster on Chromosome 8 to Smoking Dependence
Genetic Contribution of Variants in GABAergic Signaling to Nicotine Dependence
Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking and Other Addictions
Significant Contribution of Variants in Serotonin Transporter and Receptor Genes to Smoking Dependence
Converging Findings from Linkage and Association Analyses on Susceptibility Genes for Smoking Addiction
Contribution of Gene-Gene and Gene-Environmental Interactions to Tobacco Smoking
Identification of Biological Pathways Associated with Smoking Initiation/Progression, Nicotine Dependence, and Smoking Cessation
Neuroproteomics and Its Applications in Research on Nicotine and Other Drugs of Abuse
Regulatory Roles of MicroRNAs in Addictions and Other Psychiatric Diseases
Tobacco Smoking, Food Intake, and Weight Control
Nicotine Modulates Innate Immune Pathways via Nicotinic Acetylcholine Receptor
DNA Methylation Analysis Reveals a Strong Connection between Tobacco Smoking and Cancer Pathogenesis
Evolutionary Relations of Genes Encoding Nicotinic Acetylcholine Receptor Subunits
Management, Pharmacotherapies, and Precision Medicine for Smoking Cessation
Background and Biology of and Health Concerns about Electronic Cigarettes
Grand Challenges and Opportunities for Psychiatry, Including Nicotine Addiction Research.