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  • Book
    Nikolaos Labrou, editor.
    Summary: This edited work presents studies that clarify several aspects of the development and application of therapeutic enzymes. Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This book covers mainly three areas of recombinant therapeutic enzymes and their clinical and pharmaceutical technology: (i) overview of the production process and biochemical characterization of therapeutic enzymes, (ii) focuses upon the engineering strategies and delivery methods of therapeutic enzymes, (iii) clinical applications of selected therapeutic enzymes, including aspects on their mechanisms of action and information on safety, immunogenicity issues and various adverse events of the enzymes used for therapy. The topic of this book is particularly relevant to academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.

    Contents:
    Chapter 1. Introduction to therapeutic enzymes
    Chapter 2. Upstream processing technologies
    Chapter 3. Downstream processing technologies
    Chapter 4. Enzyme Manufacturing Process and Quality Control Evaluations
    Chapter 5. Regulatory guidance in the production of therapeutic enzymes
    Chapter 6. Biophysical methods for the characterization of Enzyme Therapeutics Bertrand Raynal Patrick England
    Chapter 7. Clinical Development of a therapeutic enzyme
    Chapter 8. Chemical modifications of therapeutic proteins
    Chapter 9. Formulation of therapeutic enzymes
    Chapter 10. Engineering of therapeutic enzymes for improving activity
    Chapter 11. Engineering of therapeutic enzymes for improving stability
    Chapter 12. Design and engineering of deimmunized therapeutic enzymes
    Chapter 13. Nanoparticles for delivery of therapeutic enzymes
    Chapter 14. Targeted delivery of therapeutic enzymes
    Chapter 15. Oral and inhalable enzyme therapies
    Chapter 16. Regulatory issues
    Chapter 17. Enzyme replacement therapies
    Chapter 18. Pharmacodynamics and pharmacokinetics issues of enzyme replacement therapy
    Chapter 19. Enzyme therapy for lysosomal storage disorders
    Chapter 20. Enzyme therapy for myocardial infarction
    Chapter 21. Enzyme therapy for chronic gout
    Chapter 22. Enzyme therapy for tumor lysis syndrome
    Chapter 23. Enzyme therapy for collagen-based disorders
    Chapter 24. Enzyme therapy for severe combined immunodeficiency disease
    Chapter 25. Enzyme therapy for detoxification of methotrexate
    Chapter 26. Enzyme therapy vitreomacular adhesion
    Chapter 27. L-Asparaginase as anticancer agent
    Chapter 28. Pancreatic enzyme replacement therapy
    Chapter 29. Enzymes in metabolic anticancer therapy
    Chapter 30. L-Arginase for L-Arg depletion therapy in cancer
    Chapter 31. Methionine L-lyase for L-Met depletion therapy in cancer
    Chapter 32. Enzyme therapy for celiac sprue
    Chapter 33. Acid ceramidase
    Chapter 34. Lysoso mal acid lipase
    Chapter 35. Alkaline phosphatase and hypophosphatasia
    Chapter 36. Enzybiotics: Antibiotic enzymes as drugs and therapeutics
    Chapter 37. Anti-inflammatory enzymes
    Chapter 38. Phenylalanine ammonia lyase for the treatment of phenylketonuria
    Chapter 39. Clinical applications of Hyaluronidase
    Chapter 40. Superoxide dismutase and oxidative stress modulation
    Chapter 41. Organophosphate hydrolases as catalytic bioscavengers
    Chapter 42. Novel therapeutic proteases
    Chapter 43. Genome-editing enzymes
    Chapter 44. Gene therapy for enzyme deficiency: current status and future prospects.
    Digital Access Springer 2019