BookJoana Vieira Silva, Maria João Freitas, Margarida Fardilha, editors.
Summary: Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Contents:
Preface
Tissue-specific cell signaling: introduction
Beyond the brain signaling
Cell signaling within pituitary, the master gland of the endocrine system
Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands
Signaling pathways governing activation of innate immune cells
Cell activation and signaling in lymphocytes
Signaling pathways involved in kidney and urinary tract physiology and pathology
More than androgens: hormonal and paracrine signaling in prostate development and homeostasis
Testicular signaling: team work in sperm production
Sperm signaling specificity: from sperm maturation until oocyte recognition
Hormone signaling pathways in the postnatal mammary gland
Oogenesis signaling: from development to environmental plasticity and aging
Key signaling pathways in the cardiovascular system
Growth factor signaling in the maintenance of adult lung homeostasis
The signaling pathways involved in the regulation of skeletal muscle plasticity
Adipocyte-specific signaling.