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  • Book
    Mahmoud F. Sakr.
    Summary: This volume presents and analyses the ongoing arguments, controversies, challenges and debates on thyroid disease with a view to clarifying some uncertainties, and to making suggestions that will help resolve others. Issues such as thyroid disease during pregnancy, Hashimotos disease, Hurthle cell lesions, solitary thyroid nodules, retrosternal goiter, thyroid cancer, recurrent thyroid disease, thyroidectomy techniques, post-thyroidectomy hypocalcemia, and thyroid auto-transplantation are thoroughly explored. Richly illustrated, the book offers an invaluable tool for all specialists and trainees entrusted with the care of patients suffering from thyroid disease.

    Contents:
    Intro
    Preface
    Acknowledgments
    Contents
    1: Thyroid Disease During Pregnancy
    1.1 Introduction
    1.2 Physiological Changes During Pregnancy
    1.3 Thyroid Function Tests in Pregnancy
    1.3.1 How Do Thyroid Function Tests Change During Pregnancy?
    1.3.2 What Is the Normal Range for TSH in Each Trimester?
    1.3.3 Recommendations [8]
    1.4 Screening for Maternal Thyroid Dysfunction
    1.4.1 Introduction
    1.4.2 Screening for Thyroid Dysfunction
    1.4.3 Efficacy of Case Finding
    1.4.4 Thyroid Screening in Pregnancy: Current Practice and Cost-Effectiveness 1.4.5 Recommendations
    1.4.6 Conclusion
    1.5 Iodine Deficiency During Pregnancy
    1.5.1 Requirement of Iodine During Pregnancy and Lactation
    1.5.1.1 Increase in T4 Requirements
    1.5.1.2 Transfer of T4 and Iodide from Mother to Fetus
    1.5.1.3 Increased Renal Clearance of Iodide
    1.5.1.4 Level of Urinary I2 Indicating Optimal I2 Nutrition During Pregnancy and Lactation
    1.5.2 Requirement of Iodine in Neonates
    1.5.2.1 Level of Urinary I2 Indicating Optimal I2 Nutrition in Neonates
    1.5.3 Conclusion
    1.5.4 Recommendations [8]
    1.6 Hyperthyroidism in Pregnancy 1.6.1 Definitions
    1.6.2 Causes of Thyrotoxicosis
    1.6.3 Diagnosis of Hyperthyroidism in Pregnancy
    1.6.4 Risks of Hyperthyroidism During Pregnancy on Fetal and Maternal Health
    1.6.5 Treatment of Hyperthyroidism During Pregnancy
    1.6.5.1 Caveats and Goals of Antithyroid Drug Treatment
    1.6.6 Treatment of Hyperthyroidism During the Post-partum Period
    1.6.7 Recommendations [116, 135, 137, 138]
    1.7 Hypothyroidism in Pregnancy
    1.7.1 Iodine Deprivation and Goiter Formation
    1.7.2 Overt or Subclinical Hypothyroidism?
    1.7.3 Isolated Hypothyroxinemia 1.7.4 Incidence of Hypothyroidism During Pregnancy
    1.7.5 Risks of Hypothyroidism on Fetal and Maternal Health
    1.7.6 Treatment of Hypothyroidism During Pregnancy
    1.7.6.1 Effectiveness of Levothyroxine Treatment
    1.7.6.2 Caveats of Levothyroxine (LT4) Treatment During Pregnancy
    1.7.7 Treatment of Hypothyroidism During the Post-partum Period
    1.7.8 Recommendations [8, 197]
    1.8 Autoimmune Thyroiditis in Pregnancy
    1.8.1 Incidence
    1.8.2 Risks on Fetal and Maternal Health
    1.8.3 Treatment
    1.8.4 Recommendations [8] 1.9 Infertility and Miscarriage: Impact of Thyroid Dysfunction
    1.9.1 Introduction
    1.9.2 Autoimmunity and Reproductive Failure
    1.9.3 Impact of TAI on Infertility
    1.9.4 Impact of TAI on Miscarriage
    1.9.4.1 Classical Studies
    1.9.4.2 Assisted Reproductive Techniques (ARTs) and Miscarriage
    1.9.4.3 Effect of Thyroxine Administration on Miscarriage in Women with Positive Thyroid Abs
    1.9.5 Conclusions
    1.10 Post-partum Thyroiditis
    1.10.1 Definition
    1.10.2 Incidence
    1.10.3 Clinical Evaluation and Treatment
    1.10.4 Recommendations [8]
    Digital Access Springer 2020