BookAngelo Di Giorgio, Enrico Pinto, editors ; in collaboration with Paolo Sammartino, Franco Roviello ; foreword by Giorgio De Toma.
Summary: This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authorsℓ́ℓ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.
Contents:
Foreword
Preface 1
Preface 2
Introduction
Part 1 Background
1 Peritoneal surface malignancies: definition
2 Epidemiology: the extent of the problem
3: Intraperitoneal spread: origin and mechanisms
4 Pathology and patterns of molecular biology
5 Classification of intraperitoneal spread
6 Diagnosis and assessment: clinical, radiological, and laparoscopic
Part 2 Treatment
7 Rationale for integrated procedures (combined cytoreduction and HIPEC)
8 Peritonectomy techniques
9 HIPEC techniques
10 The role of surgery
11 The role of systemic chemotherapy
12 Anesthesiology and perioperative management
13 Patient selection for treatment
14 Morbidity and mortality
15 Organizational problems, costs, and data collection
Part 3 Results of integrated treatment
16 Pseudomyxoma peritonei
17 Peritoneal mesothelioma
18 Peritoneal carcinomatosis from gastric cancer
19 Peritoneal carcinomatosis from colorectal cancer
20 Peritoneal carcinomatosis from ovarian and gynecological cancers
21 Other primary peritoneal surface malignancies
22 Peritoneal carcinomatosis from other primary tumors
23 Palliative treatments
Part 4 Perspectives
24 New trials
25 Main topics of discussion and new trends
Part 5 Conclusions.