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all 919 "D" titles

D

  • 2010
    Unni, K. Krishnan; Inwards, Carrie Y.; Dahlin, David C.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction and scope of study -- Osteochondroma (osteocartilaginous exostosis) -- Chondroma -- Benign chondroblastoma -- Chondromyxoid fibroma -- Chondrosarcoma (primary, secondary, dedifferentiated, and clear cell) -- Mesenchymal chondrosarcoma -- Osteoma -- Osteoid osteoma -- Osteoblastoma (giant osteoid osteoma) -- Osteosarcoma -- Parosteal osteosarcoma (juxtacortical osteosarcoma) -- Fibrosarcoma and desmoplastic fibroma -- Benign fibrous histiocytoma -- Malignant fibrous histiocytoma -- Myeloma -- Malignant lymphoma of bone -- Ewing tumor -- Giant cell tumor (osteoclastoma) -- Malignancy in giant cell tumor of bone -- Chordoma -- Benign vascular tumors -- Angiosarcoma and hemangiopericytoma -- Adamantinoma of long bones -- Miscellaneous unusual tumors of bone -- Conditions that commonly simulate primary neoplasms of bone -- Odontogenic and related tumors.
  • 2008 Springer
    v. II Springer
    Cagle, Philip T.; Dail, David H.; Farver, Carol F.; Fraire, Armando E.; Hammar, Samuel P.; Tomashefski, Joseph F.
    v. 1. Nonneoplastic lung disease -- v. 2. Neoplastic lung disease.
    Also available: Print – v. 1-2., 2008
  • 2006 CRCnetBASE
    Walstra, Pieter; Geurts, T. J.; Wouters, Jan T. M.
  • 2010 Springer
    Giannoudis, Peter V.; Pape, Hans-Christoph; Peitzman, Andrew B.; Schwab, C. William.
  • 2008 Ovid
    Danforth, David N.; Gibbs, Ronald S.
    Prenatal care / Vern L. Katz -- Normal labor, delivery, newborn care, and puerperium / Kirsten J. Lund and James McManaman -- Obstetric analgesia and anesthesia / Joy L. Hawkins -- Early pregnancy loss / T. Flint Porter, D. Ware Branch, and James R. Scott -- Ectopic pregnancy / Beata E. Seeber and Kurt T. Barnhart -- Genetics in obstetrics and gynecology / Kenneth Ward -- Prenatal diagnosis / Lorraine Dugoff -- Drugs in pregnancy / Jerome Yankowitz -- Ultrasound in obstetrics / Santosh Pandipati and John C. Hobbins -- Assessment of fetal well-being / Catherine Y. Spong -- Preterm labor and post-term delivery / J. Chris Carey and Ronald S. Gibbs -- Premature rupture of the membranes / Ronald S. Gibbs -- Intrauterine growth restriction / Bronwen F. Kahn, John C. Hobbins, and Henry L. Galan -- Multiple gestation / Roger B. Newman and Charles Rittenberg -- Diabetes mellitus and pregnancy / E. Albert Reece and Carol J. Homko -- Hypertensive disorders of pregnancy / Mounira Habli and Baha M. Sibai -- Medical and surgical complications of pregnancy / Deborah Krakow -- Immunologic disorders in pregnancy / D. Ware Branch, Robert M. Silver, and Kjersti Aagaard-Tillery -- Obstetric and perinatal infections / Jill K. Davies and Ronald S. Gibbs -- Human immunodeficiency virus / Howard Minkoff -- Placenta previa and abruption / Helen H. Kay -- Breech, other malpresentations, and umbilical cord complications / Timothy E. Klatt and Dwight P. Cruikshank -- Stillbirth and intrauterine fetal demise / Robert M. Silver -- Complications of labor / Donald J. Dudley -- Complications of delivery / Larry C. Gilstrap and Edward R. Yeomans -- Operative vaginal delivery / James A. Bofill and James N. Martin, Jr. -- Cesarean delivery / James R. Scott and T. Flint Porter -- Psychologic disorders of pregnancy and the postpartum period / Michael W. O'Hara and Lisa S. Segre -- Office gynecology and surgical procedures / Marian D. Damewood, William R. Keye, Jr., and Charles C. Coddington III -- Gynecologic ultrasound / Mika Thomas and Bradley J. Van Voorhis -- Pediatric and adolescent gynecology / Ann J. Davis -- Contraception / Lisa Memmel and Melissa Gilliam -- Induced abortion / Sabrina Holmquist and Melissa Gilliam -- Pelvic and sexually transmitted infections / David A. Eschenbach -- Benign vulvovaginal disorders / Lori A. Boardman and Colleen M. Kennedy -- Amenorrhea / David P. Cohen -- Abnormal uterine bleeding / Steven R. Goldstein -- Premenstrual syndrome / Robert L. Reid -- Androgen excess disorders / Richard S. Legro and Ricardo Azziz -- Infertility / Kristen P. Wright and Julia V. Johnson -- Endometriosis / Robert S. Schenken -- Menopause / Marcelle I. Cedars and Michele Evans -- Women's sexuality and sexual dysfunction / Rosemary Basson -- Chronic pelvic pain / Howard T. Sharp -- Perioperative evaluation / Jeff Peipert and Sarah Hammil -- Laparoscopic surgery / Joseph S. Sanfilippo and Lisa M. Roberts -- Hysteroscopic surgery / R. Stanford Williams -- Epidemiology, pathophysiology, and evaluation of pelvic organ support / John O. L. DeLancey -- Operative management of pelvic organ prolapse / Kris Strohbehn and Holly E. Richter -- Nonsurgical treatment of pelvic organ prolapse / Ingrid D. Nygaard -- Female urinary incontinence: epidemiology and evaluation / Peggy A. Norton --Operative management of urinary incontinence / Charles W. Nager and Amy R. Kane -- Nonsurgical management of urinary incontinence and overactive bladder / Baharak Amir and Alfred E. Bent -- Fecal incontinence and defecation disorders / Dee E. Fenner and Catherine Ann Matthews -- Leiomyomata / Arthur F. Haney -- Disorders of the breast / Mary L. Gemignani -- Vulvar and vaginal cancer / Natalie S. Gould and Joan L. Walker -- Cervical cancer / Robert L. Giuntoli II and Robert E. Bristow -- Human papillomavirus and the management of the abnormal pap test / Christine H. Holschneider -- Uterine cancer / David G. Mutch -- Ovarian and tubal cancers / Ilana Cass and Beth Y. Karlan -- Management of the adnexal mass / Susan A. Davidson -- Gestational trophoblastic neoplasms / Andrew John Li -- The special approach to solving the profession's liability crisis, improving patient safety, and preventing medical errors / Louis Weinstein and Jason K. Baxter -- Appendix: Evidence-based approach to obstetrics and gynecology / Ronald S. Gibbs.
    Also available: Print – 2008
  • Brene Brown.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 Springer
    Frank, Uwe; Daschner, Franz; Tacconelli, Evelina.
  • 2012 Springer
    Frank, Uwe; Daschner, Franz; Tacconelli, Evelina.
    Classification of the Antibiotics -- Antibiotics Marketed in the EU -- Principles of Antibiotic Therapy -- The Most Common Errors in Antibiotic Therapy -- Important Infections and Their Microbiological Diagnosis -- Cooperation with Microbiologists -- Resistance of Major Clinical Pathogens -- The Most Frequent Pathogens- Choice of Antibiotics -- Antibiotics, Antimycotics: Spectrum- Dosage- Adverse Effects- Costs -- Antibiotic Therapy of the Principal Infections in Children and Adults -- Treatment of the Most Frequent Types of Bacterial Endocarditis -- Minimal Duration of Treatment for Bacterial Infections -- Failure of Antibiotic Therapy -- Fever of Unknown Origin: Differential Diagnosis -- Dosage of Antibiotics in Impaired Renal Function -- Antibiotic Therapy in Haemodialysis, Peritoneal Dialysis, and Continuous Haemofiltration -- Antibiotic Therapy During Pregnancy and Lactation -- Antibiotics in Liver Diseases -- Diffusion of Antibiotics in Cerebrospinal Fluid and in Cerebral Abscesses -- Local Antibiotics -- Prophylactic Antibiotic Therapy -- Physical Incompatibility of Antibiotics and Antimycotics in Infusion Solutions -- Useful Websites.
  • Maindonald, J. H.; Braun, John.
  • 2005 CRCnetBASE
    Saito, Takayuki; Yadohisa, Hiroshi.
  • 2009 CRCnetBASE
    Herson, Jay.
    Introduction -- Organization of a safety monitoring program for a confirmatory trial -- Meetings -- Clinical issues -- Statistical issues -- Bias and pitfalls -- Data monitoring committee decisions -- Emerging issues.
  • Gan, Guojun; Ma, Chaoqun; Wu, Jianhong.
  • 2015
    RWJF and the Advisory Committee hosted a listening tour of five "Learning What Works" events in diverse cities across the country: Philadelphia; Phoenix; Des Moines, Iowa; San Francisco; and Charleston, South Carolina. A broad spectrum of individuals--from health care providers to researchers to community service providers to business leaders interested in using data to improve their health and the health of their communities--attended these five events. The forums generated key observations and examples, as well as many questions around using, exchanging, and protecting data and what individuals and communities want and need in order to improve health or foster connections between different sectors. These observations provided the basis for the Advisory Committee's findings and recommendations, which are detailed in this report.
  • 2008 Springer
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    Spector, Phil.
  • 2011 ScienceDirect
    Witten, I. H.; Frank, Eibe; Hall, Mark A.
    Part I. Machine Learning Tools and Techniques: -- 1. What's it all about? -- 2. Input: concepts, instances, and attributes -- 3. Output: knowledge representation -- 4. Algorithms: the basic methods -- 5. Credibility: evaluating what's been learned -- Part II. Advanced Data Mining: -- 6. Implementations: real machine learning schemes -- 7. Data transformation -- 8. Ensemble learning -- 9. Moving on: applications and beyond -- Part III. The Weka Data Mining Workbench: -- 10. Introduction to Weka -- 11. The explorer -- 12. The knowledge flow interface -- 13. The experimenter -- 14 The command-line interface -- 15. Embedded machine learning -- 16. Writing new learning schemes -- 17. Tutorial exercises for the Weka explorer.
  • 2005 books24x7, SUNet ID login required.
    Maimon, Oded Z.; Rokach, Lior.
  • Springer
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    Shasha, Dennis Elliott; Toivonen, Hannu T. T.; Wang, Jason T. L.; Zaki, Mohammed J.
  • 2011 CRCnetBASE
    Acharya U, Rajendra; Dua, Sumeet.
    "Data mining has rapidly emerged as an enabling, robust, and scalable technique to analyze data for novel patterns, trends, anomalies, structures, and features that can be employed for a variety of biomedical and clinical domains. Approaching the techniques and challenges of image mining from a multidisciplinary perspective, this book presents data mining techniques, methodologies, algorithms, and strategies to analyze biomedical signals and images. Written by experts, the text addresses data mining paradigms for the development of biomedical systems. It also includes special coverage of knowledge discovery in mammograms and emphasizes both the diagnostic and therapeutic fields of eye imaging"--Provided by publisher.
  • 2015 Springer Protocols
    Fernandez-Llatas, Carlos; García-Gómez, Juan Miguel.
    Actigraphy pattern analysis for outpatient monitoring / Elies Fuster-Garcia ... [et al.] -- Definition of loss functions for learning from imbalanced data to minimize evaluation metrics / Juan Miguel Garcia-Gómez and Salvador Tortajada -- Audit method suited for DSS in clinical environment / Javier Vicente -- Incremental logistic regression for customizing automatic diagnostic models / Salvador Tortajada, Montserrat Robles, and Juan Miguel Garcia-Gómez -- Using process mining for automatic support of clinical pathways design / Carlos Fernandez-Llatas ... [et al.] -- Analyzing complex patients' temporal histories : new frontiers in temporal data mining / Lucia Sacchi, Arianna Dagliati, and Riccardo Bellazzi -- Snow system : a decentralized medical data processing system / Johan Gustav Bellika, Torje Starbo Henriksen, and Kassaye Yitbarek Yigzaw -- Data mining for pulsing the emotion on the web / Jose Enrique Borras- Morell -- Introduction on health recommender systems / C. L. Sanchez-Bocanegra, F. Sanchez-Laguna, and J. L. Sevillano -- Cloud computing for context-aware enhanced m-health services / Carlos Fernandez-Llatas ... [et al.] -- Analysis of speech-based measures for detecting and monitoring alzheimer's disease / A. Khodabakhsh and C. Demiroglu -- Applying data mining for the analysis of breast cancer data / Der-Ming Liou and Wei-Pin Chang -- Mining data when technology is applied to support patients and professional on the control of chronic diseases : the experience of the METABO platform for diabetes management / Giuseppe Fico ... [et al.] -- Data analysis in cardiac arrhythmias / Miguel Rodrigo ... [et al.] -- Knowledge-based personal health system to empower outpatients of diabetes mellitus by means of P4 medicine / Adrián Bresó ... [et al.] -- Serious games for elderly continuous monitoring / Lenin-G. Lemus-Zúñiga ... [et al.].
  • 2011 Springer Protocols
    Eisenacher, Martin; Hamacher, Michael; Stephan, Christian.
    Instruments and methods in proteomics -- In-depth protein characterization by mass spectrometry -- Analysis of phosphoproteomics data -- The origin and early reception of sequence databases -- Laboratory data and sample management for proteomics -- PRIDE and "Database on demand" As valuable tools for computational proteomics -- Analysing proteomics identifications in the context of functional and structural protein annotation: Integrating annotation using PICR, DAS, and BioMart -- Tranche distributed repository and proteomecommons.Org -- Data standardization by the HUPO-PSI: How has the community benefitted? -- mzIdentML: An open community-built standard format for the results of proteomics spectrum identification algorithms -- Spectra, chromatograms, metadata: mzML-the standard data format for mass spectrometer output -- imzML: Imaging mass spectrometry markup language: A common data format for mass spectrometry imaging -- Tandem mass spectrometry spectral libraries and library searching -- Inter-lab proteomics: Data mining in collaborative projects on the basis of the HUPO brain proteome project's pilot studies -- Data management and data integration in the HUPO plasma proteome project -- Statistics in experimental design, preprocessing, and analysis of proteomics data -- The evolution of protein interaction networks -- Cytoscape: Software for visualization and analysis of biological networks -- Text mining for systems modeling -- Identification of alternatively spliced transcripts using a proteomic informatics approach -- Distributions of ion series in ETD and CID spectra: Making a comparison -- Evaluation of peak-picking algorithms for protein mass spectrometry -- OpenMS and TOPP: Open source software for LC-MS data analysis -- LC/MS data processing for label-free quantitative analysis -- Spectral properties of correlation matrices - towards enhanced spectral clustering -- Standards, databases, and modeling tools in systems biology -- Modeling of cellular processes: Methods, data, and requirements.
  • 2008 CRCnetBASE
    Klimberg, Ronald K.; Kudyba, Stephan; Lawrence, Kenneth D.
    An approach to analyzing and modeling systems for real-time decisions / John C. Brocklebank ... [et al.] -- Ensemble strategies for neural network classifiers / Paul Mangiameli and David West -- Neural network classification with uneven misclassification costs and imbalanced group sizes / Jyhshyan Lan ... [et al.] -- Data cleansing with independent component analysis / Guangyin Zeng and Mark J. Embrechts -- A multiple criteria approach to creating good teams over time / Ronald K. Klimberg, Kevin J. Boyle, and Ira Yermish -- Data mining applications in higher education / Cali M. Davis ... [et al.] -- Data mining for market segmentation with market share data : a case study approach / Illya Mowerman and Scott J. Lloyd -- An enhancement of the pocket algorithm with ratchet for use in data mining applications / Louis W. Glorfeld and Doug White -- Identification and prediction of chronic conditions for health plan members using data mining techniques / Theodore L. Perry, Stephan Kudyba, and Kenneth D. Lawrence -- Monitoring and managing data and process quality using data mining : business process management for the purchasing and accounts payable processes / Daniel E. O'Leary -- Data mining for individual consumer models and personalized retail promotions / Rayid Ghani ... [et al.] -- Data mining : common definitions, applications, and misunderstandings / Richard D. Pollack -- Fuzzy sets in data mining and ordinal classification / David L. Olson, Helen Moshkovich, and Alexander Mechitov -- Developing an associative keyword space of the data mining literature through latent semantic analysis / Adrian Gardiner -- A classification model for a two-class (new product purchase) discrimination process using multiple-criteria linear programming / Kenneth D. Lawrence ... [et al.].
  • Larose, Daniel T.
    Dimension reduction methods -- Regression modeling -- Multiple regression and model building -- Logistic regression -- Naïve Bayes estimation and Bayesian networks -- Genetic algorithms -- Case study : modeling response to direct mail marketing.
  • Markov, Zdravko; Larose, Daniel T.
  • 2011 CRCnetBASE
    Torgo, Luís.
    "This hands-on book uses practical examples to illustrate the power of R and data mining. Assuming no prior knowledge of R or data mining/statistical techniques, it covers a diverse set of problems that pose different challenges in terms of size, type of data, goals of analysis, and analytical tools. The main data mining processes and techniques are presented through detailed, real-world case studies. With these case studies, the author supplies all necessary steps, code, and data. Mirroring the do-it-yourself approach of the text, the supporting website provides data sets and R code" -- Provided by publisher.
  • 2011 Springer
    Williams, Graham J.
    Part 1. Explorations -- Introduction -- Getting Started -- Working with Data -- Loading Data -- Exploring Data -- Interactive Graphics -- Transforming Data -- Part 2. Building Models -- Descriptive and Predictive Analytics -- Cluster Analysis -- Association Analysis -- Decision Trees -- Random Forests -- Boosting -- Support Vector Machines -- Part 3. Delivering Performance -- Model Performance Evaluation -- Deployment -- Part 4. Appendices -- Installing Rattle -- Sample Datasets.
  • 2006 Springer
    DeMets, David L.; Friedman, Lawrence M.; Furberg, Curt.
    Also available: Print – 2006
  • 2002 NAP
    Leibowitz, Arleen; Pollack, Earl S.
  • 2006 books24x7, SUNet ID login required.
    Svolba, Gerhard.
    Pt. 1. Data preparation: business point of view -- ch. 1. Analytic business questions -- Ch. 2. Characteristics of analytic business questions -- Ch. 3. Characteristics of data sources -- Ch. 4. Different points of view on analytic data preparation -- Pt. 2. Data structures and data modeling -- Ch. 5. The origin of data -- Ch. 6. Data models -- Ch. 7. Analysis subjects and multiple observations -- Ch. 8. The one row-per-subject data mart -- Ch. 9. The multiple-rows-per-subject data mart -- Ch. 10. Data structures for longitudinal analysis -- Ch. 11. Considerations for data marts -- Ch. 11. Considerations for predictive modeling -- Pt. 3. Data mart coding and content -- Ch. 13. Accessing data -- Ch. 14. Transposing one- and multiple-rows-per-subject data structures -- Ch. 15. Transposing longitudinal data -- Ch. 16. Transformations of interval-scaled variables -- Ch. 17. Transformations of categorical variables -- Ch. 18. Multiple interval-scaled observations per subject -- Ch. 19. Multiple catagorical observations per subject -- Ch. 20. Coding for predictive modeling -- Ch. 21. Data preparation for multiple-rows-per-subject and longitudinal data marts -- Pt. 4. Sampling, scoring, and automation -- Ch. 22. Sampling -- Ch. 23. Scoring and automation -- Ch 24. Do's and don'ts when building data marts -- Pt. 5. Case studies.
  • 2007
    Refaat, Mamdouh.
    PrintStatus: Not Checked OutLane Catalog Record
    Also available: Print – 2007
  • 2011 books24x7
    Gehani, Narain.
  • 1987-
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012
    Tatonetti, Nicholas Pierino; Altman, Russ B.; Butte, Atul J.; Hastie, Trevor J.
    Small molecule drugs continue to be an important part of medical therapy. However, their use is plagued by the onset of unexpected side effects, often seen only in late-stage clinical trials or after release to the market. As a result, there have been a number of high profile drug withdrawals because of side effects. More worrisome, however, are side effects that result from drug-drug interactions (DDIs). It is very difficult to empirically study DDIs before drugs enter the market because of the small samples of co-prescribed drugs in most late stage clinical drug (Phase III) studies. Some DDIs can be predicted based on knowledge of shared pathways of metabolism--such as when two drugs share a metabolizing enzyme and so the effective levels of one or both drugs are affected by saturation of the enzyme. But many DDIs are more idiosyncratic and difficult to predict. The most difficult cases are those in which two drugs produce a synergistic effect not seen with either drug alone. Thus, I created surveillance methods to detect unexpected DDIs, relying on clinical databases--both electronic medical records and spontaneous adverse event reporting systems. Understanding DDIs has an additional benefit for drug discovery. If two drugs have a synergistic effect, they may shed new light on the molecular mechanisms of their action or of the diseases they treat. If we use a model not of "one drug-one target" but of multiple interacting cellular pathways that respond to drugs ("the network is the target"), then we can leverage DDIs for the study of disease. However, to do this we need new ways to probe and understand these pathways, such as studying the unexpected synergies between drugs in observational reporting systems. Thus it would be extremely valuable to have computational methods that link adverse events to molecular events. The emergence of large databases linking drugs, diseases, drug effects, demographics and genes offers a new opportunity to create informatics methods for greater understanding small molecule effects at the clinical and biological level. I describe studies in which I have shown the great power of integrating these databases. In particular, I used the FDA Adverse Events Reporting System (FDA-AERS) to discover a signal for abnormal glucose in patients taking both paroxetine and pravastatin. Paroxetine is a selective serotonin reuptake inhibitor antidepressant. Pravastatin is an HMG CoA reductase inhibitor cholesterol-lowering drug. Neither is typically associated with hyperglycemia. Based on my analysis of the FDA-AERS, I examined patient electronic medical records in three separate hospitals (Stanford, Harvard, Vanderbilt), and demonstrated a striking increase in glucose levels on patients on both drugs, compared to their glucose levels on only one of the drugs. I also showed that mice on these two drugs have increased glucose. I am working with FDA to consider a potential update to the drug labels. Although this discovery illustrates the power of clinical data mining, the databases I used are filled with biases that make their use treacherous. I believe there are many similarly valuable discoveries to be made in these databases. However, only with careful attention to systematic biases can I ensure that the predictions I make are valid. In this thesis I describe methods to address the major informatics challenges to detecting and understanding the effects of taking multiple drugs at once. In particular, I have shown that I can (1) remove the bias introduced by unmeasured confounding variables, (2) improve the detection of drug interactions in cases of low or even non-reporting, (3) link drug effects to genes through chemical informatics methods, and (4) validate new drug effects using novel retrospective and prospective studies. The work forms an infrastructure that is useful to (1) pharmacogenomics scientists wishing to understand drug action at the molecular level, (2) pharmacologists wishing to better understand the effects of drugs singly and in combination, and (3) regulatory agencies wishing to understand the efficacy and safety of drugs and drug-interactions at a population level.
  • 2012
    Guan, Yihan; Bjarnadottir, Margret V.; Brandeau, Margaret L.; Ye, Yinyu; Zenios, Stefanos A.
    This dissertation develops data-driven methods for healthcare risk modeling to facilitate risk identification and evaluation, focusing on post-marketing drug safety surveillance and breast cancer incidence prediction. For risk identification, we first propose a novel methodology for post-marketing drug safety surveillance: "Follow the money'', which monitors cost in health insurance claims data to detect increased spending related to adverse drug events (ADE). By using real claims data from 2.4 million insured individuals, we demonstrate that this method enables early detection of signals of ADE. Second, we recommend statistical study designs to detect rare and time-dependent ADE resulting from long-term drug use and highlight statistical considerations that drug surveillance designers should focus on when implementing a long-term surveillance. We characterize statistical properties and compare performances of a variety of surveillance designs by applying them to simulated event data as well as real health insurance claims data. For risk evaluation, we develop a stochastic simulation model of the Surveillance, Epidemiology and End Results database to quantify the impact of menopausal hormone therapy (MHT) on U.S. breast cancer incidence. Our model quantifies the promoting effect of MHT on breast tumor growth and the reduced mammographic detectability. By modeling unobservable tumor natural history dynamics and simulating individual life history at a population level, we evaluate the contribution of MHT use cessation to the observed decline in breast cancer incidence between 2002 and 2003. We also predict U.S. breast cancer incidence in the absence of MHT.
  • 2011 Springer
    Creasy, Jeff L.
    The structure of the normal brain and its imaging appearance -- The general appearance of edema and hemorrhage on CT, MR and US (including a general introduction to CT, MR and US scanning) -- The basics of contrast and its role in dating -- How the imaging appearance of edema and hemorrhage change over time on CT, MR, and US: dynamic (acute) dating -- Patterns of parenchymal injury: pattern (chronic) dating -- Principles of dynamic dating in the medical legal setting -- Principles of pattern dating in the medical legal setting -- Therefore, what can be said based on the images, and what can't be said based on the images -- The root causes of uncertainty in dating neurologic events based on imaging findings.
  • 2007 Springer
    Hansemann, David; Bignold, Leon P.; Coghlan, Brian L. D.; Jersmann, Hubertus P. A.
  • 2006
    Boon, Nicholas A.; Davidson, Leybourne Stanley Patrick.
    PrintStatus: Not Checked OutLane Catalog Record
    Good medical practice -- Good prescribing -- Molecular mechanisms of disease -- Immunological factors in disease -- Environmental and nutritional factors in disease -- Principles of infectious disease -- Ageing and disease -- Critical care and emergency medicine -- Poisoning -- Medical psychiatry -- Oncology -- Palliative care and pain management -- Infectious diseases -- Human immunodeficiency virus infection and the human acquired immunodeficiency syndrome -- Sexually transmitted infections -- Clinical biochemistry and metabolism -- Kidney and urinary tract disease -- Cardiovascular disease -- Respiratory disease -- Endocrine disease -- Diabetes mellitus -- Alimentary tract and pancreatic disease -- Liver and biliary tract disease -- Blood disorders -- Musculoskeletal disorders -- Neurological disease -- Skin disease -- Appendix.
  • 2014 ClinicalKey
    Davidson, Leybourne Stanley Patrick; Walker, Brian R.
    More than two million medical students, doctors and other health professionals from around the globe have owned a copy of Davidson's Principles and Practice of Medicine since it was first published. Today's readers rely on this beautifully illustrated text to provide up-to-date detail of contemporary medical practice, presented in a style that is concise and yet easy to read. Davidson's provides the factual knowledge required to practise medicine, explaining it in the context of underlying principles, basic science and research evidence, and shows how to apply this knowledge to the management of patients who present with problems rather than specific diseases. The book has won numerous prizes including being highly commended in the British Medical Association book awards. Davidson's global perspective is enhanced by the input of an international team of authors and a distinguished International Advisory Board from 17 countries. Building on the foundations laid down by its original editor, Davidson's remains one of the world's leading and most respected textbooks of medicine. The underlying principles of medicine are described concisely in the first part of the book, and the detailed practice of medicine within each sub-specialty is described in later system-based chapters. Most chapters begin with a two-page overview of the important elements of the clinical examination, including a manikin to illustrate the key steps in the examination of the relevant system. A practical, problem-based clinical approach is described in the 'Presenting Problems' sections, to complement the detailed descriptions of each disease. The text is extensively illustrated, with over 1000 diagrams, clinical photographs, and radiology and pathology images. 1350 text boxes present information in a way suitable for revision, including 150 clinical evidence boxes summarising the results of systematic reviews and randomised controlled trials and 65 'In Old Age' boxes highlighting important aspects of medical practice in the older population. A combined index and glossary of medical acronyms contains over 10 000 subject entries. The contents can also be searched comprehensively as part of the online access to the whole book on the StudentConsult platform. Access over 500 self-testing questions with answers linked to the book's content for further reading. The text uses both SI and non-SI units to make it suitable for readers throughout the globe.
  • 2007
    Deglin, Judith Hopfer; Vallerand, April Hazard.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Springer
    Picichè, Marco.
    Part 1. Research on Cardiac Surgery and Right Cardiac Catheterization before the Advent of Cardiopulmonary Bypass -- 1. The Discovery of Blood Circulation / Yves Glock -- 2. The History of Surgical Research / Marco Picichè -- 3. The Ignored Birth of Cardiac Surgery: The History of the Surgical Treatment of Heart Wounds and Pericardial Effusions / Vladimir Saplacan, Fabio Cuttone and Massimo Massetti -- 4. The History of Pulmonary Embolectomy Before the Advent of CPB / Marco Vola and Jean-Francois Fuzellier -- 5. Right Cardiac Catheterization Before the Advent of Cardiopulmonary Bypass / Achille Gaspardone and Giulio G. Stefanini -- 6. The History of Mitral and Tricuspid Valve Surgery Before the Advent of Cardiopulmonary Bypass / Luigi Chiariello, Paolo Nardi and Giovanni Alfonso Chiariello -- 7. Surgery of the Aortic Valve Before the Era of Cardiopulmonary Bypass / Y. Glock -- 8. The History of Myocardial Revascularization Before the Advent of Cardiopulmonary Bypass / Marco Picichè -- 9. The History of Experimental Heterotopic and Orthotopic Heart Transplantation Before Cardiopulmonary Bypass / Tyson A. Fricke and Igor E. Konstantinov -- 10. The History of Pediatric Cardiac Surgery Before the Introduction of Extracorporeal Circulation / Alessandro Frigiola -- Part 2. Research on the Cardiopulmonary Bypass Machine -- 11. On the Path to Cardiopulmonary Bypass: From Le Gallois' Experiments to Brukhonenko's Machine / Matthew S. Yong, Stephen B. Horton and Igor E. Konstantinov -- 12. Research on Cardiopulmonary Bypass in North America / Manon Caouette -- 13. From Research on Hibernation and Hypothermia to Recent Advances in Cardiopulmonary Bypass / Isabelle Plamondon and Edoardo Gasparotto -- 14. Cardiac Anaesthesia / Fabio Guarracino and Rubia Baldassarri -- Part 3. Research on Interventional Cardiology and Cardiac Surgery after the Advent of Cardiopulmonary Bypass -- 15. The History of Research on Coronary Angiography and Coronary Angioplasty / Luigi La Vecchia -- 16. Right Cardiac Catheterization After the Advent of Cpb / Achille Gaspardone and Giuilo G. Stefanini -- 17. The History of Research on Coronary Stenting / Fabrizio Tomai and Leonardo De Luca -- 18. The History of Percutaneous Valvuloplasty / Alessandro Fontanelli -- 19. Percutaneous Closure of Atrial and Ventricular Septal Defects / Achille Gaspardone and Giulio G. Stefanini -- 20. Evolution of Homografts and Prosthetic Heart Valves / Marco Picichè -- 21. The History of Research on Mitral, Tricuspid, and Aortic Valve Repair After the Advent of Cardiopulmonary Bypass / Ruggero De Paulis, Andrea Salica, Raffaele Scaffa and Luca Weltert -- 22. History of Research on Myocardial Protection / Victor S. Costache, Cristian Martu, Nicolas Chavanis, Jean Philippe Frieh and Serban Stoica -- 23. Supra-Diaphragmatic Aortic Surgery: Evolution of Material, Techniques and Brain Protection / François Dagenais -- 24. Surgical Treatment of Atrial Fibrillation / Gino Gerosa, Carlo Dal Lin and Vincenzo Tarzia -- 25. Catheter Ablation of Atrial Fibrillation / Alessio Marinelli and Domenico Corrado -- 26. The History of Cardiac Pacemakers and Defibrillators / Serge Boveda, Stéphane Garrigue and Philippe Ritter -- 27. The History of Surgery for Ischemic Heart Disease and Mechanical Complications of Myocardial Infarction After the Advent of CPB / Roland G. Demaria and Mohammed Al Yamani -- 28. Progress and Milestones in the Treatment of Deep Sternal Wound Infections / Richard Baillot and Daniel Cloutier -- 29. Engineering for IABP and ECMO / Roberto Lorusso, Attilio Renzulli and Sandro Gelsomino -- 30. The History of Research on Ventricular Assist Devices and Total Artificial Heart / Luc M. Jacquet -- 31. The History of Research on Adult and Paediatric Heart Transplantation / Johann U. Brink and Yves d'Udekem -- 32. The History of Pediatric Cardiac Surgery After the Advent of Cardiopulmonary Bypass / Jean E. Rubay -- 33. Minimally Invasive and Robotic Cardiac Surgery / Loris Salvador -- 34. The History of Research on Percutaneous, Transapical, and Sutureless Aortic Valve Replacement / Thierry Aymard and Thierry Carrel. -- 35. Erratum to: The History of Research on Percutaneous, Transapical, and Sutureless Aortic Valve Replacement / Thierry Aymard and Thierry Carrel.
  • 2013
    Rajamani, Ashok.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 ScienceDirect
    Anholt, Robert Rene Henri.
    Preface -- Introduction -- 1. Preparing a scientific presentation -- 2. The structure of a scientific presentation -- 3. Visual displays: how to (and not to) use them -- 4. Delivery -- App. A Checklist for presentations -- App. B Evaluation form.
  • 2011 CRCnetBASE
    Tobin, Stephen M.
    1. DC servo systems defined -- 2. Anatomy of a continuous-time DC servo -- 3. DC motors in servo systems -- 4. Feedback control systems -- 5. Proportional control of a second-order DC servo -- 6. Compensation of a continuous-time DC servo -- 7. DC servo amplifiers and shaft encoders -- 8. Control of a position servo using a PIC microcontroller.
  • 2011 WHO
    Part A. Report of WHO expert consultation on DDT rish characterization -- 1. Introduction -- 2. Consensus statement -- Part B. Hazard and exposure assessments -- 1. Summary and conclusions -- 2. Chemical identity -- 3. Exposure sources and metrics -- 4. Kinetics and metabolism -- 5. Hepatic effects and enzyme induction -- 6. Neurotoxicity -- 7. Immunotoxicity -- 8. Carcinogenicity -- 9. Genotoxicity -- 10. Endocrinological and reproductive effects -- 11. Hazard characterization -- 12. Exposure assessment.
    Also available: Print – 2011
  • v. 1-5, 1961-.
    Gedda, Luigi.
    PrintStatus: Not Checked OutLane Catalog Record
  • Northwest Univ
    Vesalius, Andreas; Garrison, Daniel H.; Hast, Malcolm Howard.
    This website presents Andreas Vesalius' Renaissance anatomical atlas On the Fabric of the Human Body (1543, 1555) in an exciting new way and explains the work in progress at Northwestern University to translate and annotate this historic work.
  • 2012
    Chen, Tiffany Jeahgin; Altman, Russ B.; Batzoglou, Serafim; Butte, Atul J.; Nolan, Garry P.
    Although cancer types vary widely, the number of new cancer drugs each year is severely limited. Even for those cancer therapies which are currently in use, prognostic outcomes vary significantly across cancer types. Drug discovery relies primarily on our knowledge of direct drug targets, but not the systematic off-target effects that these therapies may have. As a result, our knowledge of these drugs is somewhat limited to general mechanistic classes. Within these classes it is hard to find potential patient differences without time-intensive studies and trials. While drug classification relies on our knowledge of direct targets, it does not typically consider how a number of global cellular processes are ultimately affected. Quantifying the mechanistic differences between drugs is a difficult process. Current standards to quantify individual drug efficacy are large-scale measurements are taken at a heterogeneous population level, ignoring the effects of drug action or mechanism in single cells or cell populations. Because our knowledge is limited in this way, we are often surprised to find that similarly classified cancer drugs can have disparate effects in patients. Single-cell technologies including flow cytometry allow us to uncover relationships between drugs through simultaneous measurement of cell signal, cell cycle and cell type for each cell. Recent technological advances in flow cytometry have facilitated new clinical tests to determine cancer subtypes. In addition, these methodological advances have created potential for providing novel insights into drug mechanism and patient response. In this dissertation, I describe a new framework for performing mechanistic profiling of cancer cells. There are two facets of this problem. The first is an understanding of cancer cell cycle. Prior to treating with a drug, it is important to form a general model of how a cancer cell replicates. In a screening methodology, however, this is a difficult problem. I address this problem by building an automated, de novo model of cell cycle. Second, I perform cancer therapeutic profiling by measuring DNA damage, apoptosis, cell cycle, and cell signaling markers across multiple cancer cell types. In this thesis, I combine both cell cycle and drug profiling methods into a new drug profiling framework that can be used to find existing and novel cell cycle and drug-based biology. The results of our current work have major implications for use in profiling aberrant cell types in primary cancer samples, as well as mechanistic drug screening.
  • 2007 Springer
    Morgan, Michael B.; Smoller, Bruce; Somach, Stephen C.
  • 2009
  • 2013
    Levitt, Alexandra M.
    PrintStatus: Not Checked OutLane Catalog Record
    Despite advances in health care, infectious microbes continue to be a formidable adversary to scientists and doctors. Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes. Deadly Outbreaks recounts the scientific adventures of a special group of intrepid individuals who investigate these outbreaks around the world and figure out how to stop them. Part homicide detective, part physician, these medical investigators must view the problem from every angle, exhausting every possible source of contamination. Any data gathered in the field must be stripped of human sorrows and carefully analyzed into hard statistics. -- Jacket.
  • 2013 Springer
    Fay, Richard R.; Kral, Andrej; Popper, Arthur N.
    Deafness explores the neuronal consequences of being deaf on the peripheral and the central nervous system as well as on cognition and learning, viewed from the standpoint of genetics, neuroanatomy and neurophysiology, molecular biology, systems neuroscience, and cognitive neuroscience.
  • Brown, Reva Berman; Saunders, Mark.
    Why you need to use statistics in your research -- Understanding statistical language -- Linking data collection with analysis -- Presenting data -- Describing data -- Inferring differences and relationships from data -- What next? -- Appendix 1: Asking questions and types of data -- Appendix 2: Useful statistical software -- Appendix 3: An alphabet of statistics.
  • 2010 ebrary
    Watts, Jacqueline H.
    Death and Dying in Modern Britain -- Palliative Care Philosophy and Practice -- Hospice Development in the UK -- Spirituality -- Understanding Grief -- Supporting Bereaved People -- Issues for Policy and Practice.
  • 2012 OSO
    Miller, Franklin G.; Truog, Robert.
    Miller and Truog challenge fundamental doctrines of established medical ethics. They argue systematically that physicians legitimately cause the death of patients in the routine practices of withdrawing life support and vital organ donation.
  • 2007 CRCnetBASE
    Hanzlick, Randy.
  • 2015
    DeVita, Vincent T.; DeVita-Raeburn, Elizabeth.
    "The true story of the war on cancer from one of its generals In The Death of Cancer, Dr. Vincent T. DeVita Jr.--former director of the National Cancer Institute, former physician-in-chief at Memorial Sloan Kettering, director of the Yale Cancer Center, former president of the American Cancer Society, and developer of the first successful chemotherapy treatment for Hodgkin's lymphoma, which first demonstrated that advanced cancers of a major organ system in adults could be cured by chemotherapy--provides a personal history of one of the greatest science stories of our time, covering our fight against cancer from a man who's seen it all. But this is more than a history; it's also a work of advocacy. Despite declining mortality rates, DeVita argues, America's cancer patients are being shortchanged by timid doctors, misguided national agendas, and compromised bureaucracies. He gives readers an eye-opening look at the strengths and weaknesses of America's most prestigious cancer centers, showing how patients can use this information to their advantage. Though we're rapidly approaching total victory over cancer, he contends, we need to do more to synthesize our progress and help doctors put it into practice. This is an ambitious book about a life-or-death subject, a vital entry into the cancer literature genre. With historical depth and authenticity, DeVita brings important information to readers about what cancer is, how best to fight it, and what we still have to learn"-- Provided by publisher.
  • 2009 Springer
    Kalthoff, Holger.
    The role of TNF in cancer / Harald Wajant -- Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses / Madhu Ramaswamy ... [et al.] -- FasL expression and reverse signaling / M. Lettau ... [et al.] -- Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling / Stefan Schütze and Wulf Schneider-Brachert -- Ubiquitination and TNFR1 signaling / Ken-ichi Fujita and Srinivasa M. Srinivasula -- From biochemical principles of apoptosis induction by TRAIL to application in tumour therapy / Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak -- Therapeutic targeting of TWEAK/Fn14 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway / Jennifer S. Michaelson and Linda C. Burkly -- APRIL in B-cell malignancies and autoimmunity / Fiona C. Kimberly, Jan Paul Medema, and Michael Hahne -- Autophagy in cancer and chemotherapy / Shida Yousefi and Hans-Uwe Simon -- Glucocorticoid-mediated apoptosis resistance of solid tumors / Ingrid Herr, Markus W. Büchler, and Jürgen Mattern -- Targeting death-receptors in radiation therapy / Olivier Niemöller and Claus Belka -- Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands / Jeannette Gerspach, Harald Wajant, and Klaus Pfizenmaier.
    Also available: Print – 2009
  • 2005 Springer
    El-Deiry, Wafik S.
  • Kastenbaum, Robert.
    As we think about death -- What is death? -- The death system -- Dying -- Hospice and palliative care -- End-of-life issues and decisions -- Suicide -- Violent death : murder, terrorism, genocide, disaster, and accident -- Euthanasia, assisted death, abortion, and the right to die -- Death in the world of childhood -- Bereavement, grief, and mourning -- The funeral process -- Do we survive death? -- How can we help? -- Good life, good death?
  • 2015 Springer
    Cooley, Dennis R.
    1. A pragmatic method -- 2. A pragmatic framework of values and principles: the beginning -- 3. Defining and valuing properties and individuals -- 4. What harm does death do to the decedent? -- 5. How should we feel about our own death? -- 6. How should we feel about another's death? -- 7. Is there a duty to die? -- 8. A duty to suicide -- Index.
  • 2014 Springer
    Regmi, Krishna.
    Current economic, demographic, and environmental shifts are presenting major challenges to health care systems around the world. In response, decentralization--the transfer of control from central to local authorities--is emerging as a successful means of meeting these challenges and reducing inequities of care. But as with health care itself, one size does not fit all, and care systems must be responsive to global reality as well as local demand. Decentralizing Health Services explores a variety of applications of decentralization to health care delivery in both the developing and developed worlds. Outfitted with principles, blueprints, and examples, this ambitious text clearly sets out the potential role of decentralized care as a major player in public health. Its models of service delivery illustrate care that is effective, inclusive, flexible, and in tune with the current era of preventive and evidence-based healthcare. Contributors point out opportunities, caveats, and controversies as they: Clarify the relationships among decentralization, politics, and policy Differentiate between political, fiscal, and administrative decentralization in health care systems. Consider public/private partnerships in health systems. Explain how the effects of decentralization can be evaluated. Present the newest data on the health outcomes of decentralization. Explore some challenges and global issues of health systems in the 21st century. And each chapter features learning goals, discussion questions, activities, and recommendations for further reading. Heralding changes poised to revolutionize care, Decentralizing Health Services will broaden the horizons of researchers and administrators in health services, health economics, and health policy.
  • 2005 Springer
    Carel, J.-C; Christen, Yves; Kelly, Paul A.
  • 2013
    Klak, Lauren Marie; Bishop, Julius; Howard, Ronald A.; Shachter, Ross D.
    Limb threatening trauma to the leg may be treated with either limb salvage (retention process) or amputation (prosthetic process). Limb salvage allows the patient to keep his leg and avoid using a prosthetic; however, it typically has higher probabilities than amputation of complications, additional time in the hospital, and chronic pain. The optimal treatment is still under debate and the current methods to make the decision do not explicitly incorporate the patient's preferences or the patient's medical insurance. This dissertation develops a decision analysis model to help a patient think clearly about the retention process vs. the prosthetic process. The model updates conditional probabilities of various outcomes based on the patient's demographics and develops a method to explicitly incorporate the patient's preferences for keeping the leg, avoiding chronic pain, and avoiding time in the hospital. The model also calculates the probabilities of hospital and prosthetic costs for the patient's health insurance and risk attitude. The decision analysis model in this dissertation utilizes preferences from the patient to inform the decision, facilitates effective discussions between the doctor and the patient, and provides a comprehensive recommendation to the patient.
  • 2013 ScienceDirect
    Pammi, V. S. Chandrasekhar; Srinivasan, Narayanan.
    This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields.This volume explores interdisciplinary research on decision making taking a neural and behavioural approach *Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research *Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered *All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.
  • 2011 Thieme eNeurosurgery
    Fessler, Richard G.; Sandhu, Faheem A.; Voyadzis, Jean-Marc.
    "The art and science of spinal surgery has been in constant evolution since the early middle ages. The majority of advances, however, have occurred after World War II with the advent of antibiotics, better imaging, improved diagnostic methods, and surgical care. In the past five to ten years, a greater understanding of spinal anatomy and the development of more sophisticated radiological imaging and instrumentation have further illuminated what is possible in spinal care. Decision Making in Minimally Invasive Spine Surgery adds to the historical continuum by compiling a collection of chapters that define why a minimally invasive approach should be chosen and how to perform such a procedure, written by authors who have established themselves as experts in the field"--Provided by publisher.
  • 2007
    Bready, Lois L.; Dillman, Dawn; Noorily, Susan H.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 Thieme eNeurosurgery
    Frontera, Jennifer A.
    From important aspects of the physical examination to imaging studies to treatment options and dosage guidelines, this book provides a solid introduction to the evidence-based management of patients in the neurological intensive care unit. Succinct text in a highly accessible bullet-point format details the essentials of history-taking, physical examination, differential diagnosis, diagnostic evaluation, and treatments for a range of neurological problems in the critical care setting.
  • v. 1-2, 2011 Springer
    v. 2, 2011 Springer
    Brady, Luther W.; Lu, J. J.
  • 2013 Thieme eNeurosurgery
    Anderson, D. Greg; Vaccaro, Alexander R.
    "Decision Making in Spinal Care, 2nd Edition presents current management strategies for the most common spine problems, including trauma injuries, metabolic and degenerative diseases, and spinal deformities. Each chapter opens with a concise introduction to the topic and discussion of the classification of the injury, condition, or management approach. The authors then describe the diagnostic workup of the patient, the treatment options available, the likely outcome, and possible complications. Chapters also include useful decision making algorithms"--Provided by publisher.
  • 2014 Springer
    Gasper, Laurie E.; Nieder, C.
    A look at the recent oncology literature or a search of one of the common databases reveals a steadily increasing number of nomograms and other prognostic models, some of which are also available in the form of web-based tools. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, et cetera Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment concepts and also the need for approaches that achieve a favorable balance between effectiveness and side-effects. Moreover, optimal resource utilization requires prognostic knowledge, for example to avoid lengthy and aggressive treatment courses in patients with a short survival expectation. In order to avoid misuse, it is important to understand the limits and caveats of prognostic and predictive models. This book provides a comprehensive overview of such decision tools for radiation oncology, stratified by disease site, which will enable readers to make informed choices in daily clinical practice and to critically follow the future development of new tools in the field.
  • Carter, K. Codell.
    Bloodletting and inflammation -- Bloodletting and social norms -- Disease and causes of disease in early nineteenth century medical thought -- The Early nineteenth century conception of quackery -- The Edinburgh bloodletting controversy -- Ignaz Semmelweis and the adoption of etiological concepts of disease -- The Collapse of traditional medicine and the rise of medical science -- The Current crisis in epidemiology.
  • 2007
    Sayres, Rory.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014
    Shershow, Scott Cutler.
    Preface: the sacred part -- Methodological introduction: a strategy and protocol of deconstruction -- Dignity and sanctity -- Dignity and sovereignty -- Human dignity from Cicero to Kant -- The right to die: mapping a contemporary debate -- Suicide and sacrifice from Plato to Kant -- Sacrifice and the right to die -- A debate deconstructed.
  • 2012
    Rinaldi, Jacob; Clandinin, Thomas R.; Greicius, Michael D.; Moore, Tirin; Raymond, Jennifer L.
    This thesis is composed of experimental and analytic work deconstructing the cerebellar learning algorithm. The central finding is that two parallel neural circuits, with independent instructive signals, support cerebellum-dependent learning. An analytic framework for this result, based on overcoming signal-dependent noise, is proposed.
  • 2011
    Havenstrite, Karen; Blau, Helen M.; Nolan, Garry P.; Wang, Clifford.
    The ultimate goal of regenerative medicine is to repair tissues damaged by aging, injury or disease. Tissue-specific adult stem cells constitute a reservoir of cells in postnatal tissue that have the remarkable capacity to proliferate and repair tissue damage because they can both self-renew, or produce more stem cells, and differentiate into mature cells. Adult stem cells have been identified in a variety of tissues, including blood, brain, skin, intestine, and muscle and methods exist to prospectively isolate these populations by flow cytometry. Upon transplantation, they possess an extraordinary ability to contribute extensively to tissue regeneration. Notably, adult stem cells are a relatively rare cell population and methods to propagate and expand these cell types in culture without loss of regenerative capacity are lacking, a hurdle to their clinical use. In vivo, stem cells reside in an instructive microenvironment, or niche, which serves to regulate fate decisions, including quiescence, self-renewal, and differentiation. Given the complexity of their native environment, it is not surprising that upon removal from their niche they rapidly lose regenerative capacity. While the role of biochemical signals in regulating stem cell fate and function has been widely explored, the effects of biophysical signals have not been discerned. To elucidate the role of matrix elasticity in regulating adult stem cell fate, we first design a biomimetic hydrogel culture platform to mimic tissue elasticity and physiologic presentation of biochemical cues. Adapting a previously described conjugate addition reaction, poly(ethylene glycol) hydrogel substrates are fabricated which have a Young's modulus that is tunable in the physiologic range (1-50kPa). Gels are designed to have limited post-polymerization swelling to enable constant density of tethered biological ligands. Utilizing this tunable hydrogel culture platform, we provide the first definitive evidence that matrix elasticity regulates adult stem cell self-renewal in culture. Using a combination of culture studies and in vivo functional assays in mice, we demonstrate that substrate rigidity profoundly impacts the self-renewal potential of tissue-specific adult stem cells isolated from skeletal muscle and bone marrow. In contrast with rigid tissue culture plastic in which regenerative potential is lost, we demonstrate that culture on a pliant hydrogel substrate maintains the 'stemness' of muscle stem cells (MuSCs) and hematopoetic stem cells (HSCs). Further, we describe a novel in vivo screen and identify an extracellular matrix molecule which, in conjunction with soft hydrogel, has a previously unrecognized role in regulating HSC fate. These studies demonstrate that recapitulating tissue rigidity, a key component of the in vivo microenvironment, enables propagation of functional adult stem cells in culture for the first time. We expect these experimental approaches will be broadly applicable to other adult stem cell types and ultimately will profoundly impact regenerative medicine by enabling generation of functional stem cell populations for use in clinical cell-based therapies.
  • 2012 Springer
    Denys, Damiaan; Feenstra, Matthijs; Schuurman, Rick.
    Basic Principles of Deep Brain Stimulation / F. L. H. Gielen and G. C. Molnar -- Neural Circuits Affected by Deep Brain Stimulation for the Treatment of Psychiatric Disorders / Suzanne N. Haber and Benjamin D. Greenberg -- Mechanisms of Action of Deep Brain Stimulation for the Treatment of Psychiatric Disorders / J. Luis Lujan and Cameron C. McIntyre -- Deep Brain Stimulation in the Ventral Capsule/Ventral Striatum for the Treatment of Obsessive-Compulsive Disorder: Role of the Bed Nucleus of the Stria Terminalis / Loes Gabriëls and Bart Nuttin -- Deep Brain Stimulation in Obsessive-Compulsive Disorder Targeted at the Nucleus Accumbens / Pelle P. de Koning, Pepijn van den Munckhof, Martijn Figee, Rick Schuurman and Damiaan Denys -- What is the Role of the Subthalamic Nucleus in Obsessive-Compulsive Disorder? Elements and Insights from Deep Brain Stimulation Studies / William I. A. Haynes and Luc Mallet -- Obsessive-Compulsive Disorders in Animals / Christine Winter -- Subcallosal Cingulate Cortex Deep Brain Stimulation for the Treatment of Refractory Mood Disorders: Evidence and Challenges / Peter Giacobbe, Nir Lipsman and Andres M. Lozano -- Deep Brain Stimulation of the Human Reward System as a Putative Treatment for Refractory Major Depression / T. E. Schlaepfer, V. A. Coenen and B. H. Bewernick -- Depression in Humans: The Ventral Capsule/Ventral Striatum / Mayur Pandya, Andre Machado and Donald Malone -- Deep Brain Stimulation in Animal Models of Depression / Brian W. Scott, José N. Nobrega and Clement Hamani -- Deep Brain Stimulation in Tourette Syndrome / L. Ackermans, I. Neuner, J. Kuhn and V. Visser-Vandewalle -- Surgical Treatments for Drug Addictions in Humans / Bomin Sun and Wei Liu -- Manipulating Addictive Behaviour in Animal Models / Rolinka M. C. Schippers, Tommy Pattij and Taco J. De Vries -- Neuropsychiatric Side Effects of Deep Brain Stimulation in Parkinson's Disease / Christine Daniels and Jens Volkmann -- Psychiatric Aspects of Parkinson's Disease in Animal Models of Deep Brain Stimulation of the Subthalamic Nucleus / S. K. H. Tan, H. Hartung, V. Visser-Vandewalle, T. Sharp and Y. Temel -- Scientific Recordings in Deep Brain Stimulation / Michael X. Cohen -- Neurotransmitter Release During Deep Brain Stimulation / Osama A. Abulseoud, Emily J. Knight and Kendall H. Lee -- The Potential Role of Nonneuronal Cells in the Deep Brain Stimulation Mechanism: What Are Glia? What Are Their Functions? Could They Be Players in Deep Brain Stimulation? / Vinata Vedam-Mai, Michael S. Okun and Elly M. Hol -- Animal Studies in Deep Brain Stimulation Research / Matthijs G. P. Feenstra and Damiaan Denys -- Neuroimaging Deep Brain Stimulation in Psychiatric Disorders / Martijn Figee, Pepijn van den Munckhof, Rick Schuurman and Damiaan Denys -- Optogenetic Strategies for the Treatment of Neuropsychiatric Disorders: Circuit-Function Analysis and Clinical Implications / Daniel L. Albaugh and Garret D. Stuber -- Next-Generation Electrodes for Steering Brain Stimulation / H. C. F. Martens, M. M. J. Decré and E. Toader -- Future Applications: Nanotechniques / Russell J. Andrews, Jessica E. Koehne and Meyya Meyyappan -- Ethical Guidance for the Use of Deep Brain Stimulation in Psychiatric Trials and Emerging Uses: Review and Reflections / Emily Bell and Eric Racine -- History of "Psychiatric" Deep Brain Stimulation: A Critical Appraisal / Marwan I. Hariz.
  • 2015 Springer
    Itakura, Tōru.
    Chronic electrical stimulation of the brain has become a standard surgical therapy for Parkinson's disease, with many studies demonstrating excellent outcomes without any serious complications. Recently this surgical intervention has also been applied to various other neurological diseases, such as involuntary movement disorders, intractable pain, and psychological conditions including depression and obsessive-compulsive disorder. This comprehensive, up-to-date textbook will meet the needs of all who wish to learn more about the application of deep brain stimulation and will provide a sound basis for safe and accurate surgery. The book comprises two main parts, the first of which presents relevant anatomical and functional background information on the basal ganglia, thalamus, and other brain structures as well as on the mechanism of brain stimulation. The second part describes clinical studies on deep brain stimulation, covering results in a range of movement disorders and psychiatric diseases and also important aspects of instrumentation and technique. The authors are outstanding scientists and experts in the field from across the world. This book will be welcomed by all young neurosurgeons, neurologists, psychiatrists, and other medical staff who are interested in electrical stimulation of the brain for the treatment of neurological disorders.
  • 2008 Springer
    Okun, Michael S.; Starr, Philip A.; Tarsy, Daniel; Vitek, Jerrold Lee.
  • 2011 Springer
    De Nardi, Paola; Candiani, Massimo; Denny, Elaine; Ferrari, Stefano.
    Introduction / Paola De Nardi and Stefano Ferrari -- Diagnosis / Paola De Nardi and Stefano Ferrari -- Treatment / Paola De Nardi and Stefano Ferrari -- The Experience of Living with Endometriosis / Elaine Denny.
  • 2013 Springer Protocols
    Shomron, Noam.
    Introduction to high-throughput sequencing experiments : design and bioinformatics analysis / Rachelly Normand and Itai Yanai -- Compressing resequencing data with GReEn / Armando J. Pinho, Diogo Pratas, and Sara P. Garcia -- On the accuracy of short read mapping / Peter Menzel ... [et al.] -- Statistical modeling of coverage in high-throughput data / David Golan and Saharon Rosset -- Assembly algorithms for deep sequencing data : basics and pitfalls / Nitzan Kol and Noam Shomron -- Short read mapping for exome sequencing / Xueya Zhou ... [et al.] -- Profiling short tandem repeats from short reads / Melissa Gymrek and Yaniv Erlich -- Exome sequencing analysis : a guide to disease variant detection / Ofer Isakov, Marie Perrone, and Noam Shomron -- Identifying RNA editing sites in miRNAs by deep sequencing / Shahar Alon and Eli Eisenberg -- Identifying differential alternative splicing events from RNA sequencing data using RNASeq-MATS / Juw Won Park ... [et al.] -- Optimizing detection of transcription factor-binding sites in ChIP-seq experiments / Aleksi Kallio and Laura L. Elo -- Statistical analysis of ChIP-seq data with MOSAiCS / Guannan Sun ... [et al.] -- Detection of reverse transcriptase termination sites using cDNA ligation and massive parallel sequencing / Lukasz J. Kielpinski ... [et al.].
  • 2005 Springer
    Schultz, Carsten.
    Also available: Print – 2005
  • 2007 Springer
    Ulvestad, Elling.
  • 2013
    Son, Min-Sun; Gold, Garry E.; Hargreaves, Brian A.; Levenston, Marc Elliot.
    Meniscal degeneration often precedes cartilage degeneration, and effective detection and treatment can be critical in preventing osteoarthritis. The meniscus is a heterogeneous tissue, and obtaining information on the varying characteristics of meniscal regions is important in investigating such strategies. However, no current method exists that can detect such meniscal heterogeneity in the tissue matrix. In addition, the lack of quantitative information on meniscal heterogeneity hinders the development an effective, long-term solution that can treat degeneration in the meniscus. The purpose of this dissertation was thus 1) to find quantitative characteristics that defined meniscal heterogeneity and 2) to evaluate non-invasive diagnostic methods that could reflect the matrix tissue properties and detect meniscal heterogeneity. To accomplish the first goal, gene expression profiles of meniscal cells were statistically analyzed to identify quantitative markers that could distinguish between different regions of the meniscus, describing its heterogeneous properties. This information was then used to evaluate cell sources for meniscal tissue engineering, demonstrating the potential application of these quantitative markers in developing an effective treatment for meniscal degeneration. Secondly, in order to detect meniscal heterogeneity, which is reflected in the changing tissue properties within the tissue, magnetic resonance imaging was used. The potential of the imaging parameters T1[rho] and T2 relaxation times in detecting various meniscal tissue properties, including the matrix composition and mechanical properties, was examined. Ultimately, such information would be useful in identifying internal degenerative changes that take place in the matrix of the tissue prior to macroscopic injuries. In this study, both T1[rho] and T2 relaxation times showed variation with tissue properties but were highly correlated with one another, indicating that only one imaging parameter might be necessary as a diagnostic tool in a clinical setting. In addition, an exploratory aim visualized the internal secondary collagen network in the meniscus and examined its deformation in different mechanical loading positions. This work significantly adds to the understanding of the heterogeneous properties of the meniscus and the potential of magnetic resonance imaging parameters as detection markers. It contributes to the advancement of diagnosis and treatment strategies for meniscal degeneration, which has further implications for preventing osteoarthritis progression.
  • 2012
    Del Vecchio, Catherine Amalia; Clarke, Michael F.; Cleary, Michael L.; Palmer, Theo D.; Wernig, Marius; Wong, Albert J.
    Glioblastoma multiforme (GBM) is the most common and deadly primary brain tumor. Amplification and rearrangements of the epidermal growth factor receptor (EGFR) gene are frequently found in GBM, and the most common variant is EGFRvIII. Here we report that EGFRvIII is a novel cancer stem cell (CSC) or tumor initiating cell marker in GBM. EGFRvIII expression is restricted to sub-regions and sporadic cells within the tumor and EGFRvIII is frequently co-expressed in the putative CSC CD133+ population. EGFRvIII gene and protein expression can be maintained when primary GBM are cultured as tumor derived neurospheres and is lost when spheres are exposed to differentiating conditions. Furthermore, cells that express both EGFRvIII and CD133 display the greatest self-renewal and tumor initiating abilities when compared to the single positive or double negative populations. If amplification and rearrangement are early events in tumorigenesis, this implies that they should be preserved across the tumor despite focal expression. Unexpectedly, we found EGFR amplification and rearrangement throughout the tumor, including regions with no EGFRvIII expression. To study this phenomenon, we characterized three GBM cell lines with endogenous EGFRvIII expression. EGFRvIII defined a hierarchy and epigenetic mechanisms played a role in maintaining heterogeneous EGFRvIII expression, suggesting that drugs which modulate the epigenome might be used successfully in glioblastoma tumors. To assess a broad applicability of our findings to other tumor types, we investigated EGFRvIII expression and amplification in primary breast carcinoma. Our analyses confirmed the presence of EGFRvIII, but in the absence of amplification or rearrangement of the EGFR locus. Interestingly, EGFRvIII was often expressed in a subset of tumor cells and was co-expressed in the putative CSC CD44+/CD24-/low population. EGFRvIII-expressing cells had increased expression of stem cell and epithelial-mesenchymal transition (EMT) associated genes and increased in vitro sphere formation and in vivo tumor formation compared to non-expressing cells. Mechanistically, EGFRvIII mediated its effects through the Wnt/[beta]-catenin pathway. Collectively, this data suggests a novel function for EGFRvIII in tumorigenesis and further supports the use of EGFRvIII-targeted therapy in these tumor types.
  • 2014 Springer
    Petras, Hanno; Sloboda, Zili.
    Prevention Science: An Epidemiological Approach -- Individual Physical, Cognitive, and Emotional Vulnerability Across the Life Course: Benchmarks and Developmental Challenges -- Benchmarks, Developmental Challenges, and Risks During the Prenatal and Infancy Period -- Childhood and the Entry into Adolescence: A Pivotal Period in Health-Related Behaviors and Prevention -- Adolescence and Early Adulthood -- Stressors and Vulnerabilities in Middle and Old Age: Opportunities for Prevention -- Environmental Influences and Implications for Intervention Development -- Family -- School Influences on Child and Youth Development -- Peer Networks -- Risk and Resilience Processes in Single-Mother Families: An Interactionist Perspective -- Environmental Influences: The Workplace and Mental Health-Models, Vulnerability Factors, and Interventions -- An Integrated Prevention Science Model: A Conceptual Foundation for Prevention Research -- Design of Prevention Interventions -- Implementation Science and the Effective Delivery of Evidence-Based Prevention -- Factors Affecting Implementation: Cultural Adaptation and Training -- Measuring Fidelity -- Research Design -- Translating the Intervention Approach into an Appropriate Research Design: The Next-Generation Adaptive Designs for Effectiveness and Implementation Research -- The Epidemiologic Case-Crossover and Case-Control Approaches in Prevention Research -- The Use of Simulation Models in Public Health with Applications to Substance Abuse and Obesity Problems -- Meta-analysis in Prevention Science -- Mixed Methods Research Design for Prevention Science: Methods, Critiques, and Recommendations -- Analytic Methods -- Latent Class Analysis in Prevention Science -- Discrete-Time Survival Analysis in Prevention Science -- Using Mediation and Moderation Analyses to Enhance Prevention Research -- Advances in Missing Data Models and Fidelity Issues of Implementing These Methods in Prevention Science -- Cost Analysis and Policy -- Economic Analysis and Policy Studies: Special Challenges in the Prevention Sciences -- Strengthening Prevention Science to Ensure Effectiveness of Intervention in Practice: Setting up an International Agenda.
  • 2008/2009
    Case, Lauren Christine.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009
    Chang, Debbie Jimway.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007
    MacDougall, Christina A.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 CRCnetBASE
    Finucane, Edward W.
  • 2015 Springer
    Kainmueller, Dagmar.
    Segmentation of anatomical structures in medical image data is an essential task in clinical practice. Dagmar Kainmueller introduces methods for accurate fully automatic segmentation of anatomical structures in 3D medical image data. The author's core methodological contribution is a novel deformation model that overcomes limitations of state-of-the-art Deformable Surface approaches, hence allowing for accurate segmentation of tip- and ridge-shaped features of anatomical structures. As for practical contributions, she proposes application-specific segmentation pipelines for a range of anatomical structures, together with thorough evaluations of segmentation accuracy on clinical image data. As compared to related work, these fully automatic pipelines allow for highly accurate segmentation of benchmark image data. Contents Deformable Meshes for Accurate Automatic Segmentation Omnidirectional Displacements for Deformable Surfaces (ODDS) Coupled Deformable Surfaces for Multi-object Segmentation From Surface Mesh Deformations to Volume Deformations Segmentation of Anatomical Structures in Medical Image Data Target Groups Academics and practitioners in the fields of computer science, medical imaging, and automatic segmentation. The Author Dagmar Kainmueller works as a research scientist at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, with a focus on bio image analysis. The Editor The series Aktuelle Forschung Medizintechnik - Latest Research in Medical Engineering is edited by Thorsten M. Buzug.
  • 2007 Springer
    Farag, Aly A.; Suri, Jasjit S.
  • 2014 Springer
    Mullaji, Arun B.; Shetty, Gautam M.
    "With rapid advancement in technology and materials in total knee arthroplasty (TKA), long-term survival and function of the total knee is now more and more dependent on restoring accurate limb alignment, precise component position and optimum soft-tissue balance. Proper technique is key to ensuring this and is all the more crucial and challenging to achieve in arthritic knees with severe and complex deformities. Correction of such knee deformities forms an important part of TKA for orthopedic surgeons working in both emerging and developed nations. Deformity Correction in Total Knee Arthroplasty fills the void that exists in treating severe and complex knee deformities and the use of computer-navigation in TKA. It covers the principles of deformity correction and soft-tissue balancing in primary TKA in an illustrative, step-wise and algorithmic fashion. Starting with the initial key step of preoperative planning, this book goes on to specifically describe how to deal with different types of deformities encountered in patients who undergo TKA - varus, valgus, flexion, hypertension, rotational and extra-articular deformities - as well as the stiff knee, the unstable knee, osteotomies in primary TKA and postoperative pain management and rehabilitation. This focused how-to manual includes plentiful images and clear, concise text from authors who have performed thousands of TKAs, making it a must-have reference for any surgeon unfamiliar or frequently confronted with this type of procedure."--Publisher's website.
  • 2015 AccessMedicine
    Brown, Donald D.; DeGowin, Elmer Louis; LeBlond, Richard F.; Suneja, Manish; Szot, Joseph F.
    Diagnosis -- History taking and the medical record -- The screening physical examination -- Vital signs, anthropometric data, and pain -- Non-regional systems and diseases -- The skin and nails -- The head and neck -- The chest : chest wall, pulmonary, and cardiovascular systems; the breasts -- Abdomen, perineum, anus, and rectosigmoid -- The urinary system -- The female genitalia and reproductive system -- Male genitalia and reproductive system -- The spine, pelvis and extremities -- The nervous system -- The mental status, psychiatric, and social evaluations -- The preoperative evaluation -- Principles of diagnostic testing -- Common laboratory tests.
  • 2009 AccessMedicine
    Brown, Donald D.; DeGowin, Richard L.; LeBlond, Richard F.
    Diagnosis -- History taking and the medical record -- The screening physical examination -- Vital signs, anthropometric data, and pain -- Non-regional systems and diseases -- The skin and nails -- The head and neck -- The chest : chest wall, pulmonary, and cardiovascular systems; the breasts -- Abdomen, perineum, anus, and rectosigmoid -- The urinary system -- The female genitalia and reproductive system -- Male genitalia and reproductive system -- The spine, pelvis and extremities -- The neurologic examination -- The mental status, psychiatric, and social evaluations -- The preoperative evaluation -- Principles of diagnostic testing -- Common laboratory tests.
    Also available: Print – 2009
  • 2013
    Nishimuta, James Francis; Andriacchi, Thomas P.; Goodman, Stuart B.; Levenston, Marc Elliot; Smith, R. Lane.
    Osteoarthritis is a debilitating disease that affects 27 million Americans. Major risk factors for osteoarthritis include mechanical injury and obesity. Prolonged exposure to mechanical overload in the knee joint, either by injury, malalignment, or obesity, is associated with early onset of osteoarthritis. Recent evidence demonstrates that adipose tissue is a metabolically active and produces systemic biofactors known as adipokines associated with numerous diseases including cardiovascular disease, hypertension, insulin resistance, rheumatoid arthritis, and osteoarthritis. Interestingly, obesity is a significant risk factor for hand osteoarthritis, suggesting a biologic link between obesity and osteoarthritis that is perhaps mediated through adipokines. While many studies investigating in vitro osteoarthritic degradation have focused on cartilage tissue, the menisci has received relatively little attention despite it's important functional role in joint stability and load transfer in the knee. The purpose of this thesis was to explore the relative susceptibility of cartilage and meniscal tissue degradation to in vitro mechanical overload and adipokine exposure using an immature bovine tissue explant model. To explore the injury response, explants of cartilage and meniscal tissues were compressed at various strain rates to create a spectrum of peak injury forces and cultured for up to nine days post-injury. To investigate whether adipose tissue and adipokines can biochemically induce changes in cartilage and meniscal tissues, explants of cartilage and meniscal tissue were incubated with infrapatellar fat pad or individual adipokines and assessed for altered matrix metabolism. Overall, results indicate that, while mechanically robust, meniscal tissue is vulnerable to biologic damage induced by mechanical overload and adipokines. We also demonstrate for the first time that meniscal tissue is more catabolically sensitive to adipokines than cartilage tissue. These results provide evidence that obesity-driven degradation of knee joint could be biochemically mediated and suggest meniscal degradation as a possible early event in osteoarthritis development.
  • 2013 Ovid
    Campbell, William W.; DeJong, Russell N.
    Introduction -- Overview of the nervous system -- The neurologic history -- The general physical examination -- General outline of the neurologic examination -- Gross and microscopic anatomy of the cerebral hemispheres -- Functions of the central cortex and regional cerebral diagnosis -- The mental status examination -- Disorders of speech and language -- Agnosia, apraxia, and related disorders of higher cortical function -- An overview of brainstem and cranial nerve anatomy -- The olfactory nerve -- The optic nerve -- The ocular motor nerves -- The trigeminal nerve -- The facial nerve -- The acoustic (vestibulocochlear) nerve -- The glossopharyngeal and vagus nerves -- The spinal accessory nerve -- The hypoglossal nerve -- Brainstem and multiple cranial nerve syndromes -- Overview of the motor system -- The motor unit level -- The spinal cord level -- The corticospinal (pyramidal) level -- The extrapyramidal level -- Motor strength and power -- Muscle tone -- Muscle volume and contour -- Abnormalities of movement -- Overview of the sensory system -- The exteroceptive sensations -- The proprioceptive sensations -- The interoceptive, or visceral, sensations -- Cerebral sensory functions -- Sensory localization -- Introduction to the reflexes -- The deep tendon or muscle stretch reflexes -- The superficial (cutaneous) reflexes -- Pathologic reflexes -- Postural and righting reflexes -- Associated movements -- Cerebellar function -- Gait and station -- The autonomic nervous system -- Peripheral neuroanatomy and focal neuropathies -- Neck and back pain -- Other musculoskeletal disorders -- The blood supply of the brain -- The ventricular system and the cerebrospinal fluid -- The examination in coma -- Miscellaneous neurologic signs -- Diagnostic reasoning and neurologic differential diagnosis.
  • v. 1-5, 2004 CRCnetBASE
    Contescu, Cristian I.; Putyera, Karol; Schwarz, James A.
    v. 1. A-C -- v. 2. D-Mec -- v. 3. Met-Nano -- v. 4. Near-R -- v. 5. S-XYZ.
  • 2014 MD Consult
    2014 ClinicalKey
    Miller, Mark D.; Thompson, Stephen R.
    The revised DeLee & Drez's Orthopaedic Sports Medicine covers the surgical, medical, and rehabilitation/injury prevention topics related to athletic injuries and chronic conditions with coverage of both pediatric and aging athletes; important non-orthopaedic conditions involved in the management of the athlete; rapidly evolving techniques; and sports-related fractures. It aids in understanding rehabilitation and other therapeutic modalities in the context of return to play. It also covers arthroscopic techniques, including ACL reconstruction, allograft cartilage transplantation, rotator cuff repair, and complications in athletes, as well as injury prevention, nutrition, pharmacology, and psychology in sports.
  • 2013 Springer
    Cefaro, Giampiero Ausili; Genovesi, Domenico; Perez, Carlos A.
    Defining organs at risk is a crucial task for radiation oncologists when aiming to optimize the benefit of radiation therapy, with delivery of the maximum dose to the tumor volume while sparing healthy tissues. This book will prove an invaluable guide to the delineation of organs at risk of toxicity in patients undergoing radiotherapy. The first and second sections address the anatomy of organs at risk, discuss the pathophysiology of radiation-induced damage, and present dose constraints and methods for target volume delineation. The third section is devoted to the radiological anatomy of organs at risk as seen on typical radiotherapy planning CT scans, with a view to assisting the radiation oncologist to recognize and delineate these organs for each anatomical region head and neck, mediastinum, abdomen, and pelvis. The book is intended both for young radiation oncologists still in training and for their senior colleagues wishing to reduce intra-institutional variations in practice and thereby to standardize the definition of clinical target volumes.
  • 2010 Ovid
    Basford, Jeffrey R.; DeLisa, Joel A.; Frontera, Walter R.; Gans, Bruce M.; Robinson, Lawrence R.; Walsh, Nicholas E.
    Machine generated contents note: pt. I Principles of Assessment and Evaluation -- 1.Clinical Evaluation / Stephen F. Noil -- 2.The Physical Examination / Peter J. Moley -- 3.Assessment of Human Muscle Function / Jan Lexell -- 4.Electrodiagnostic Evaluation of the Peripheral Nervous System / Lawrence R. Robinson -- 5.Human Walking / Brian L. Bowyer -- 6.Imaging Techniques Relative to Rehabilitation / Angel Gomez -- 7.Diagnostic Ultrasound / Yi-Pin Chiang -- 8.Principles and Applications of Measurement Methods / Kathleen A. Hinderer -- 9.Functional Evaluation and Management of Self-care and Other Activities of Daily Living / Kristine L. Haerti -- 10.Disability Determination / Richard T. Katz -- 11.Applying the ICF in Rehabilitation Medicine / Alarcos Cieza -- 12.Systematically Assessing and Improving the Quality and Outcomes of Medical Rehabilitation Programs / Anne C. Hansen -- pt. II The Rehabilitation Team: Systems-Based Practice -- 13.Rehabilitation Team Function and Prescriptions, Referrals, and Order Writing / Amit Mehta -- 14.Psychological Aspects of Rehabilitation / Daniel E. Rohe -- 15.Speech, Language, Swallowing, and Auditory Rehabilitation / Jennifer Ryder -- 16.Sexuality and Disability / Andrei Krassioukov -- 17.Vocational Rehabilitation, Independent Living, and Consumerism / David Delambo -- 18.Community Participation and the Environment: Theoretical, Assessment and Clinical Implications / Daniel K. White -- 19.Systems-Based Practice of Physical Medicine and Rehabilitation / Jared Fleisher -- 20.Ethical Issues in Rehabilitation Medicine / Janet F. Haas -- 21.Interactions with the Medicolegal System / Steve R. Geiringer -- 22.International Aspects of the Practice of Rehabilitation Medicine / Chang-Il Park -- pt. III Major Conditions -- 23.Stroke Rehabilitation / Murray E. Brandstater -- 24.Traumatic Brain Injury / Tessa Hart -- 25.Multiple Sclerosis / Alexander Rae-Grant -- 26.Rehabilitation of Persons with Parkinson's Disease and Other Movement Disorders / Donna Moxley Scarborough -- 27.Rehabilitation of Spinal Cord Injury / Monifa Brooks -- 28.Adult Motor Neuron Disease / Gregory T. Carter -- 29.Peripheral Neuropathy / Maya Therattil -- 30.Myopathy / David D. Kilmer -- 31.Osteoarthritis / Sausheen Heslop -- 32.Disorders of the Cervical Spine / David I. Lipetz -- 33.Rehabilitation of Lumbar Spine Disorders: An Evidence-Based Clinical Practice Approach / Carlo Trevisan -- 34.Scoliosis and Other Spinal Deformities / Scott M. Paul -- 35.Upper Extremity Soft-Tissue Injuries / Kathleen Fink -- 36.Cumulative Trauma Disorders / Joanne Borg-Stein -- 37.Hand Disorders / Lynn H. Gerber -- 38.Foot Disorders / Lynn H. Gerber -- 39.The Prevention and Treatment of Osteoporosis / Gopi Kasturi -- 40.Rehabilitation of the Patient with Rheumatic Diseases / Lynn H. Gerber -- 41.Cardiac Rehabilitation / Matthew Bartels -- 42.Rehabilitation of the Patient with Respiratory Dysfunction / Eric Altschuler -- 43.Burn Rehabilitation / M. Catherine Spires -- 44.Rehabilitation for Patients with Cancer Diagnoses / Deborah J. Franklin -- 45.Vascular Diseases / Vincent J. Yacyshyn -- 46.Transplantation Medicine: A Rehabilitation Perspective / Michael Munin -- 47.Rehabilitation of the Individual with HIV / Steven M. Fine -- pt. IV Secondary Conditions and Complications -- 48.Physical Inactivity: Physiological and Functional Impairments and Their Treatment / Kathleen R. Bell -- 49.Treatment of the Patient with Chronic Pain / Maxim Eckmann -- 50.Spasticity and Muscle Overactivity as Components of the Upper Motor Neuron Syndrome / Neil N. Jasey, Jr. -- 51.Neurogenic Bladder and Bowel / Steven A. Steins -- 52.Pressure Ulcers / Kath Bogie -- pt. V Special Populations -- 53.Sports Medicine / Garrett S. Hyman -- 54.Physical Activity for People with Disabilities / Jennifer A. Gray-Stanley -- 55.Performing Arts Medicine / Katie Weatherhogg -- 56.Children with Disabilities / Michael Armento -- 57.Adults with Childhood-Onset Disabling Conditions / Dennis Matthews -- 58.Empowering Women with Disabilities to be Self-Determining in their Health Care / Cassing Hammond -- 59.Aging and Rehabilitation / Hilary C. Siebens -- 60.Primary Care for Persons with Disability / Amanda Harrington -- pt. VI Management Methods -- 61.Therapeutic Exercise / Daniel A. Judelson -- 62.Aquatic Rehabilitation / Andrew J. Cole -- 63.Therapeutic Physical Agents / G. David Baxter -- 64.Manipulation, Massage, and Traction / Gregory Thompson -- 65.Pharmacotherapy of Disability / Jiaxin J. Iran -- 66.The Pharmacology of Analgesic Agents / Antonio Hernandez -- 67.Injection Procedures / Maxim Eckmann -- 68.Spinal Injection Procedures / Evish Kamrava -- 69.Palliative Care Symptom Management / Andrea L. Cheville -- 70.Evolution of Biofeedback in Physical Medicine and Rehabilitation / He (Helen) Huang -- 71.Therapeutic Electrical Stimulation in Neurorehabilitation / John Chae -- 72.Functional Neuromuscular Electrical Stimulation / John Chae -- 73.Assistive Technology / Cathy Bodine -- 74.Upper and Lower Extremity Prosthetics / Daniel Santa Maria -- 75.Upper Limb Orthotics / Heikki Uustal -- 76.Lower Extremity Orthotics, Shoes, and Gait Aids / Alberto Esquenazi -- 77.Spinal Orthotics / Eva Durand -- 78.Wheelchairs / Rosemarie Cooper -- 79.Complementary and Alternative Medicine / David Jung Seto -- pt. VII Scientific Advances -- 80.Evidence-Based Practice in Rehabilitation (Including Clinical Trials) / Alan M. Jette -- 81.Neural Repair and Plasticity / Steven C. Cramer -- 82.Regenerative Medicine: Implications in Rehabilitation / Fabrisia Ambrosio -- 83.Rehabilitation Robotics / N. Hogan.
    Also available: Print – v. 1-2, 2010.
  • 2013 NAP
    Balogh, Erin; Ganz, Patricia; Levit, Laura A.; Nass, Sharyl J.
    "In the United States, approximately 14 million people have had cancer and more than 1.6 million new cases are diagnosed each year. However, more than a decade after the Institute of Medicine (IOM) first studied the quality of cancer care, the barriers to achieving excellent care for all cancer patients remain daunting. Care often is not patient-centered, many patients do not receive palliative care to manage their symptoms and side effects from treatment, and decisions about care often are not based on the latest scientific evidence. The cost of cancer care also is rising faster than many sectors of medicine--having increased to 125 billion in 2010 from 72 billion in 2004--and is projected to reach 173 billion by 2020. Rising costs are making cancer care less affordable for patients and their families and are creating disparities in patients' access to high-quality cancer care. There also are growing shortages of health professionals skilled in providing cancer care, and the number of adults age 65 and older--the group most susceptible to cancer--is expected to double by 2030, contributing to a 45 percent increase in the number of people developing cancer. The current care delivery system is poorly prepared to address the care needs of this population, which are complex due to altered physiology, functional and cognitive impairment, multiple coexisting diseases, increased side effects from treatment, and greater need for social support. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis presents a conceptual framework for improving the quality of cancer care. This study proposes improvements to six interconnected components of care: (1) engaged patients; (2) an adequately staffed, trained, and coordinated workforce; (3) evidence-based care; (4) learning health care information technology (IT); (5) translation of evidence into clinical practice, quality measurement and performance improvement; and (6) accessible and affordable care. This report recommends changes across the board in these areas to improve the quality of care. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis provides information for cancer care teams, patients and their families, researchers, quality metrics developers, and payers, as well as HHS, other federal agencies, and industry to reevaluate their current roles and responsibilities in cancer care and work together to develop a higher quality care delivery system. By working toward this shared goal, the cancer care community can improve the quality of life and outcomes for people facing a cancer diagnosis."--Publisher's description.
  • 2008 CRCnetBASE
    Garti, Nissim.
    pt. 1. The effectiveness of controlled release and delivery systems -- pt. 2. Materials and techniques for controlled release and delivery of nutrients -- pt. 3. Delivery and controlled release of particular nutraceuticals -- pt. 4. Regulatory issues and future trends.
  • 2009. Karger
    Giannakopoulos, P.; Hof, Patrick R.
    Clinical investigations in primary care / de Souza, L.C. ... [et al.] -- The concept of mild cognitive impairment : relevance and limits in clinical practice / Michon, A. -- Pathological substrates of cognitive decline in Alzheimer's disease / Giannakopoulos, P. ... [et al.] -- Functional imaging in mild cognitive impairment and early Alzheimer's disease : is it pertinent? / Ibáñez, V.; Deiber, M.-P. -- Electrophysiological markers of rapid cognitive decline in mild cognitive impairment / Giannakopoulos, P. ... [et al.] -- The future : new methods of imaging exploration in Alzheimer's disease / Nordberg, A. -- Pharmacological interventions in primary care : hopes and illusions / Assal, F.; van der Meulen, M. -- Investigations in primary care / Poggesi, A.; Pantoni, L. -- The concept of vascular cognitive impairment / Erkinjuntti, T.; Gauthier, S. -- Defining the neuropathological background of vascular and mixed dementia and comparison with magnetic resonance imaging findings / Gold, G. -- Is it possible to treat vascular dementia? / Zekry, D. -- Dementia with Lewy bodies : clinical diagnosis and therapeutic approach / Gold, G. -- Significance of brain lesions in Parkinson disease dementia and Lewy body dementia / Jellinger, K.A. -- Delineating dementia with Lewy bodies : can magnetic resonance imaging help? / von Gunten, A.; Meuli, R. -- Pharmacotherapy of Parkinson disease dementia and Lewy body dementia / Gauthier, S. -- Clinical features and diagnosis of frontotemporal dementia / Kertesz, A. -- Neuropathological spectrum of frontal lobe dementias / Kövari, E. -- Frontotemporal dementia neuroimaging : a guide for clinicians / Seeley, W.W. -- Frontotemporal dementia : therapeutic interventions / Mendez, M.F.
  • 2014 Springer
    Larner, A. J.
    This concise, pragmatic, pocket-sized book addresses neurological contributions to the diagnosis and management of dementia through a longitudinal examination of the work undertaken in a dedicated neurological dementia clinic. It covers the use of cognitive and non-cognitive screening instruments and their diagnostic utility and the use of other diagnostic investigations: neuroimaging, neurophysiology and neuropathology. The diagnostic mix is discussed in terms of both neuropsychological syndromes and neurological diagnoses, as is the use of conventional treatments for dementia and the impact of national directives (e.g. NICE, National Dementia Strategy) on day-to-day clinical practice. Dementia in Clinical Practice: A Neurological Perspective, Second Edition is an illustrated, practical resource for medical professionals involved in the assessment and management of dementia patients. It is of particular benefit to neurologists, psychiatrists, geriatricians, primary care practitioners and those working in the fields of neuropsychology, psychology, occupational therapy, speech and language therapy and nursing.
  • 2012 Springer
    Larner, A. J.
    Referral patterns -- Congitive assessment -- Noncognitive assessment and combinations of scales -- Investigation -- Diagnosis -- Management.
  • 2008 ScienceDirect
    Duyckaerts, C.; Litvan, Irene.
    Also available: Print – 2008
  • 1946- United Nations
  • 1970-71.
    Belleville, J. E.; Franklin, G. F.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2016 Springer
    Athreya, Sriharsha.
  • 2009 Springer
    Adorini, L.; Lombardi, Giovanna; Riffo-Vasquez, Yanira.
  • 2001 ScienceDirect
    Lotze, Michael T.; Thomson, Angus W.
    Also available: Print – 2001
  • 2009 Springer
    Salter, Russell David; Shurin, Michael R.
    The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin -- Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
  • 2008 Springer
    Onji, M.; Akbar, S. M. F.
  • 2005 Springer
    Ludwig, Mike.
  • 2009 WHO
    "Since the second edition of Dengue haemorrhagic fever: diagnosis, treatment, prevention and control was published by the World Health Organization (WHO) in 1997, the magnitude of the dengue problem has increased dramatically and has extended geographically to many previously unaffected areas. It was then, and remains today, the most important arthropod-borne viral disease of humans. Activities undertaken by WHO regarding dengue are most recently guided at the global policy level by World Health Assembly resolution WHA55.17 (adopted by the Fifty-fifth World Health Assembly in 2002) and at the regional level by resolution CE140.R17 of the Pan American Sanitary Conference (2007), resolution WPR/RC59.R6 of the WHO Regional Committee for the Western Pacific (2008) and resolution SEA/RC61/R5 of the WHO Regional Committee for South-East Asia (2008). This new edition has been produced to make widely available to health practitioners, laboratory personnel, those involved in vector control and other public health officials, a concise source of information of worldwide relevance on dengue. The guidelines provide updated practical information on the clinical management and delivery of clinical services; vector management and delivery of vector control services; laboratory diagnosis and diagnostic tests; and surveillance, emergency preparedness and response. Looking ahead, some indications of new and promising avenues of research are also described. Additional and more detailed specific guidance on the various specialist areas related to dengue are available from other sources in WHO and elsewhere, some of which are cited in the references. The contributions of, and review by, many experts both within and outside WHO have facilitated the preparation of this publication through consultative and peer review processes. All contributors are gratefully acknowledged, a list of whom appears under "Acknowledgements". These guidelines are the result of collaboration between the WHO Department of Control Neglected Tropical Diseases, the WHO Department of Epidemic and Pandemic Alert and Response, and the Special Programme for Research and Training in Tropical Diseases. This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity, since many aspects of the prevention and control of dengue are currently being investigated in a variety of studies. The guidelines contain the most up-to-date information at the time of writing. However, the results of studies are being published regularly and should be taken into account. To address this challenge, the guide is also available on the Internet and will be updated regularly by WHO." - p. v.
    Also available: Print – 2009
  • 2014 Future Med
    Farrar, Jeremy; Whitehorn, James.
    Dengue : transmission, diagnosis and surveillance / James Whitehorn & Jeremy Farrar -- Biomarkers for dengue : prospects and challenges / Sophie Yacoub, Annette Fox, Nguyen Van Kinh, Gavin Screaton & Heiman Wertheim -- Dengue diagnosis : commercially available kits and laboratory support / Monique da Rocha Queiroz Lima, Rita Maria Ribeiro Nogueira & Flávia Barreto dos Santos -- Lessons learned from dengue : focus on Taiwan / Tzong-Shiann Ho, Chiou-Feng Lin, Ching-Chuan Liu, Trai-Ming Yeh, Robert Anderson & Yee-Shin Lin -- Dengue and international travel / Silvia Odolini, Alberto Matteelli & Francesco Castelli -- Intraepidemic increases in dengue disease severity : applying lessons on surveillance & transmission / Scott B. Halstead -- Prospects for controlling dengue spread : vaccines and vector control / Monica A. McArthur, Marcelo B. Sztein & Robert Edelman -- Ask the experts : surveillance of global dengue distribution / Jane Messina, Oliver Brady, Simon Hay, Jeremy Farrar & James Whitehorn -- Multiple choice questions : answers.
  • 2010 Springer
    Rothman, Alan L.
    Prospective cohort studies of dengue viral transmission and severity of disease / Timothy P. Endy, In-Kyu Yoon, Mammen P. Mammen -- Control of dengue virus translation and replication / Suman M. Paranjape, Eva Harris -- Subversion of interferon by dengue virus / Jorge L. Munoz-Jordan -- Dengue virus virulence and transmission determinants / R. Rico-Hesse -- Systemic vascular leakage associated with dengue infections - the clinical perspective / Dinh D. Trung, Bridget Wills -- Markers of dengue disease severity / Anon Srikiatkhachorn, Sharone Green -- Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis / Alan L. Rothman -- HLA and other gene associations with dengue disease severity / H.A.F. Stephens -- Vector dynamics and transmission of dengue virus: implications for dengue surveillance and prevention strategies / Thomas W. Scott, Amy C. Morrison -- Dengue vaccine candidates in development / Anna P. Durbin, Stephen S. Whitehead -- Targeted mutagenesis as a rational approach to dengue virus vaccine development / Joseph E. Blaney Jr., Anna Pl Durbin, Brian R. Murphy, Stephen S. Whitehead.
    Also available: Print – 2010
  • 2013
    Varki, Ajit; Brower, Danny L.
    Describes why humans are able to deny reality and ignore their own inevitable deaths to the detriment of the entire species and what might be done to change this mindset.
  • 2006 Karger
    Lussi, Adrian.
  • 2013 ClinicalKey
    Little, James W.
    Patient evaluation and risk assessment -- Cardiovascular disease -- Pulmonary disease -- Gastrointestinal disease -- Genitourinary disease -- Endocrine and metabolic disease -- Immunologic disease -- Hematologic and oncologic disease -- Neurologic, behavioral, and psychiatric disorders.
  • 2007 Springer
    Bailey, Shara Elaine; Hublin, Jean-Jacques.
    Dental evolution and dental morphology: Introduction / S.E. Bailey -- Patterns of molar variation in great apes and their implications for hominin taxonomy / V. Pilbrow -- Trends in postcanine occlusal morphology within the hominin clade : the case of Paranthropus / S.E. Bailey and B.A. Wood -- Maxillary molars cusp morphology of South African australopithecines / J. Moggi-Cecchi and S. Boccone -- Gran Dolina-TD6 and Sima de los Huesos dental samples : preliminary approach to some dental characters of interest for phylogenetic studies / M. Martinón-Torres ... [et al.] -- Neural network analysis by using the Self-Organizing Maps (SOMs) applied to human fossil dental morphology : a new methodology / F. Manni, R. Vargiu and A. Coppa -- Micro-computed tomography of primate molars : methodological aspects of three-dimensional data collection / A.J. Olejniczak, F.E. Grine and L.B. Martin -- HRXCT analysis of hominoid molars : a quantitative volumetric analysis and 3D reconstruction of coronal enamel and dentin / D.G. Gantt, J. Kappelman and R.A. Ketcham -- Dental microstructure and life history: Introduction / R. Macchiarelli and S.E. Bailey -- Inferring primate growth, development and life history from dental microstructure : the case of the extinct Malagasy lemur, Megaladapis / G.T. Schwartz, L.R. Godfrey and P. Mahoney -- Histological study of an upper incisor and molar of a bonobo (Pan paniscus) individual / F. Ramirez Rossi and R.S. Lacruz -- New perspectives on chimpanzee and human molar crown development / T.M. Smith ... [et al.] -- Portable confocal scanning optical microscopy of Australopithecus africanus enamel structure / T.G. Bromage ... [et al.] -- Imbricational enamel formation in Neandertals and recent modern humans / D. Guatelli-Steinberg ... [et al.] -- Dental development: Introduction / B.A. Wood -- Of mice and monkeys : quantitative genetic analyses of size variation along the dental arcade / L.J. Hlusko and M.C. Mahaney -- Quantifying variation in human dental development sequences : an evo-devo perspective / J. Braga and Y. Heuze -- Dental calcification stages of the permanent M1 and M2 in U.S. children of African-American and European-American ancestry born in the 1990s / J. Monge ... [et al.] -- A computerized model for reconstruction of dental ontogeny : a new tool for studying evolutionary trends in the dentition / P. Smith ... [et al.] -- Dentition and diet: Introduction / F.E. Grine -- An evaluation of changes in strontium/calcium ratios across the neonatal line in human deciduous teeth / L.T. Humphrey, M.C. Dean and T.E. Jeffries -- Dental topography and human evolution with comments on the diets of Australopithecus africanus and Paranthropus / P.S. Ungar -- Dental microwear and paleoanthropology : cautions and possibilities / M.F. Teaford -- Tooth wear and diversity in early hominid molars : a case study / L. Ulhaas, O. Kullmer and F. Schrenk -- 3-D interferometric microscopy applied to the study of buccal enamel microwear / F. Estebaranz ... [et al.].
  • 2013 Springer
    Yildirim, Sibel.
    Dental Evolution -- Tooth development -- Dental Pulp is a Connective Tissue -- Dental Pulp Stem Cells (DPSC) -- Isolation methods of DPSC -- Characterization of DPSC -- Reprogramming of DPSC to induced pluripotent stem cells (iPSC) -- Immunomodulatory effects of DPSC -- Dental Pulp is a Complex Adaptive System.
  • 2015 Thieme
    Fuhrmann, Andreas.
  • 2007 ScienceDirect
    Scharfman, Helen E.
  • 2012 ScienceDirect
    Bloch-Zupan, Agnès; Scully, Crispian; Sedano, Heddie O.
  • 2006 Springer
    Peters, Godefridus Johannes.
  • 2015 Springer
    Balakrishnan, Nikhil.
    1. The Principles of Dependability -- 2. System Safety Assessment -- 3. Fault Tree Analysis -- 4. Failure Modes and Effects Analysis -- 5. Machine Learning Methods with Applications to Diagnosis -- 6. Byzantine Medical Problems: Decision Making with Misleading, Imperfect Information -- 7. Process Driven Methods in Diagnosis and Treatment -- 8. Toyota Production System -- 9. Reliance Implementation Methods Applied to a Kaizen Project -- 10. Knowledge & Culture.
  • 2010
    Clemons, Heather Jean; Brown, Patrick O.; Chu, Gilbert; Kingsley, David M.; Krasnow, Mark.
    Adipose tissue is found in diverse depots throughout the human body. The diversity of physiological specialization of these fat depots is reflected in the diverse depot-specific alterations seen in lipodystrophies and links between specific patterns of fat distribution and susceptibility to diseases, including Type II Diabetes and coronary artery disease. Previous studies, although focused on only 2 major fat depots (omental and abdominal subcutaneous), have identified numerous differences in metabolic, endocrine and developmental programs. We carried out a more extensive and higher resolution investigation of the anatomic specialization of white adipose tissue, based on 59 samples collected from 7 anatomically diverse fat depots, from 56 individuals. Using DNA microarrays we measured relative abundance of ~25,000 distinct mRNAs in each adipose tissue sample and in adipocytes and stromal-vascular cells isolated from each sample, and compared their gene expression patterns with ~120 samples representing diverse non-adipose tissues. Adipocytes from different regions of the body displayed distinct gene expression profiles. Characteristic patterns of expression of HOX genes distinguished adipocyte samples by site of origin; these patterns were recapitulated when adipocyte precursors from each site were cultured and differentiated ex vivo, suggesting that these genes may have a role in programming and/or maintaining depot-specific differentiation of adipocytes. Expression in adipocytes of 300 genes with major roles in energy metabolism showed both depot-dependent and inter-individual variation. Some of the patterns suggested important differences among anatomic depots in metabolic roles. For example, a set of genes involved in lipid uptake and storage and hormone-regulated lipolysis were generally most highly expressed in breast, pericolonic and omental adipocytes whereas genes involved in glycogen metabolism and de novo fatty acid synthesis were generally most highly expressed in breast and abdominal subcutaneous adipocytes, suggesting that these depots play a role as glucose buffers. Dozens of genes known or predicted to encode secreted molecular signals were highly expressed in adipocytes compared to either adipose stromal-vascular cells or other organs; many of these were differentially expressed among adipocyte depots. Some of these genes appear to be good candidates for encoding novel adipokines. In summary, we found extensive variation among adipose depots, as well as inter-individual variation, in global gene expression. Differences in genes linked to development, metabolism and cell-cell communication suggest new hypotheses relevant to depot-specific and general aspects of adipocyte biology.
  • 2010 Karger
    Cryan, J. F.; Leonard, B. E.
    Antidepressant compounds : a critical review / S.W. Tang, D.M. Helmeste, B. Leonard -- The hypothalamic-pituitary-adrenal axis in depression / M. Julio-Pieper, T.G. Dinan -- Dysfunctional circadian rhythms and mood disorders : opportunities for novel therapeutic approaches / T.R. Norman -- The concept of depression as a dysfunction of the immune system / B.E. Leonard -- The role of polyunsaturated fatty acids in the pathology and treatment of depression / C. Song -- Overcoming antidepressant treatment resistance : focus on glutamate / J.W. Murrough, S.J. Mathew -- Neuroimaging and the pathophysiology and treatment of depression : recent advances and future needs / D.M. Cannon -- Animal models of depression : where are we going? / D.A. Slattery, J.F. Cryan -- Genetic models of depression and antidepressant response / I. Lucki -- The role of 5-HT2C receptors in the antidepressant response : a critical review / C.B.P. Martin ... [et al.] -- Chromatin-based treatments for affective disorders : insight or utopia / H.E. Covington III, O. Berton -- Neurotrophic factors and antidepressant action : recent advances / O.F. O'Leary, E. Castron -- Neurogenic basis of antidepressant action : recent advances / A. Tanti, C. Belzung -- The nature and treatment of therapy-resistant depression / S.H. Kennedy, S.J. Rizvi, P. Giacobbe -- Optimizing antidepressant management of depression : current status and future perspectives / T.L. Schwartz, S.M. Stahl.
  • 2008 Springer
    Walker, Carl.
  • 2008 Springer
    Aguilar-Gaxiola, Sergio; Gullotta, Thomas.
    Depression ranks as a leading mental health problem among Hispanic immigrants and their US-born children. And a wide array of issues - starting with the widespread stereotype of the "illegal immigrant" - makes the Latino experience of this condition differ from that of any other group. Depression in Latinos consolidates the conceptual, diagnostic, and clinical knowledge base on this salient topic, providing coverage from prevalence to prevention, from efficient screening to effective interventions. In this concise yet comprehensive volume, leading clinicians, researchers, and academics offer extensive research and clinical findings, literature reviews (e.g., an in-depth chapter on the Mexican American Prevalence and Services Survey), and insights gathered from first-hand experience in clinical practice. Perceptive information is offered on the most urgent and complex issues on depression in this diverse and dynamic population, including: (1) the impact language, culture, and societal factors have on depression and its diagnosis; (2) the most relevant assessment instruments; (3) how depression manifests among Latino children, youth, and seniors as well as in Latinas; (4) the relationship between depression and substance abuse; (5) the most effective evidence-based treatment methods; and (6) the efficacy of interventions for depression at the community level.
  • 2009 Springer
    Fondacci, Clarisse.
  • 2011
    Greenblatt, Ethan Joseph; Bogyo, Matthew; Elias, Joshua; Harbury, Pehr A. B.; Kopito, Ron.
    The degradation of misfolded secretory proteins is ultimately mediated by the ubiquitin-proteasome system in the cytoplasm, therefore endoplasmic reticulum-associated degradation (ERAD) substrates must be dislocated across the ER membrane through a process driven by the AAA ATPase p97/VCP. Derlins recruit p97/VCP and have been proposed to be part of the dislocation machinery. Here we report that Derlins are inactive members of the rhomboid family of intramembrane proteases and bind p97/VCP through C-terminal SHP boxes. Human Derlin-1 harboring mutations within the rhomboid domain stabilized mutant [alpha]-1 antitrypsin (NHK) at the cytosolic face of the ER membrane without disrupting the p97/VCP interaction. We propose that substrate interaction and p97/VCP recruitment are separate functions that are essential for dislocation and can be assigned respectively to the rhomboid domain and the C terminus of Derlin-1. These data suggest that intramembrane proteolysis and protein dislocation share unexpected mechanistic features.
  • 2005 CRCnetBASE
    Riviere, J. Edmond.
  • 2014 WHO
    Also available: Print – 2014
  • 2013 Springer
    Kamolz, Lars-Peter; Lumenta, David Benjamin.
    Skin: Architecture and Function -- Skin Tissue Engineering -- Use of Novel Biomaterial Design and Stem Cell Therapy in Cutaneous Wound Healing -- In Vivo Visualisation of Skin Graft Revascularisation -- The Role of Elastin in Wound Healing and Dermal Substitute Design -- Surface Modi fi cation by Cold Gasplasma: A Method to Optimise the Vascularisation of Biomaterials -- Collagen Matrices with Enhanced Angiogenic and Regenerative Capabilities -- 3D Visualisation of Skin Substitutes -- Wound Coverage Technologies in Burn Care-Established and Novel Approaches -- Collagen Implants in Hernia Repair and Abdominal Wall Surgery -- The Use of Dermal Substitutes in Dermatosurgery -- The Use of Dermal Substitutes in Breast Reconstruction: An Overview -- Reconstruction of the Skin in Posttraumatic Wounds -- Subdermal Tissue Regeneration -- Bioengineering and Analysis of Oral Mucosa Models -- The Use of Dermal Substitutes in Burn Surgery: Acute Phase -- Burn Reconstruction.
  • 2011 Springer
    Hiatt, Kim M.; Smoller, Bruce R.
    An Overview of Cutaneous Lymphomas -- Vascular Tumors -- Histiocytic Proliferations -- ʺFibrohistiocyticʺ Proliferations -- Tumors of Fat, Nerve, and Smooth Muscle -- Cutaneous Metastases -- Further Reading.
  • 2012 Springer
    Bercovitch, Lionel; Perlis, Clifford.
    Part I. Dermatologist as Clinician -- 1. "Excuse Me...": Unsolicited Dermatologic Opinions: Ethical, Moral, and Legal Issues / Lionel Bercovitch -- 2. "Give Me Enbrel(TM) or Give Me Death": Confronting the Limits of Autonomy / Lionel Bercovitch -- 3. Direct-to-Consumer Advertising of Prescription Medications: Misguided "Autonomy" in the Information Age / Lisa Pappas-Taffer and Alexander Miller -- 4. Autonomy, Isotretinoin and iPLEDGE: The Ethics of Burdensome Regulation and Use of Teratogenic Medication / Kenneth E. Bloom and Lionel Bercovitch -- 5. "Who Speaks for the Child?" Consent, Assent, and Confidentiality in Pediatric Dermatology / Kenneth E. Bloom and Lionel Bercovitch -- 6. Therapeutic Privilege: If, When, and How to Lie to Patients / Richard G. Fried and Clifford Perlis -- 7. Communicating with Patients About Adverse Medical Events: If, When, and How to Say "I'm Sorry" / Steven Shama, Lyn Duncan, and Lionel Bercovitch -- 8. The Computer Will See You Now: Ethics of Teledermatology / Jennifer L. Weinberg, Rachel H. Gormley, and Carrie L. Kovarik -- 9. Hospital Consultations: Embracing Professionalism Even When It Hurts / Lauren E. Krug and Stephen E. Helms -- 10. The Extender Is In: Delegating Ethically, Ethical and Professional Issues Relating to Physician Extenders in Dermatology / Steven Rosenberg and Clifford Perlis -- Part II. Dermatologist as Professional -- 11. Professional Boundaries: Safeguarding the Physician-Patient Relationship / Brandon H. Krupp -- 12. Taking Care of Uncle Bob's Rash: Should One Treat Family Members? / Sandra Osswald -- 13. Peering into the Gift Horse: Is It Ethical to Accept Gifts from Patients? / Lionel Bercovitch -- 14. The Dermatologist and Social Media: The Challenges of Friending and Tweeting / Jennifer A. Sbicca and Stanton K. Wesson -- 15. Respecting Differences: Dermatology in a Diverse Society / Vimal Prajapati and Benjamin Barankin -- 16. Dermatologists Within, Beyond and Struggling with Borders: The Global Dermatologist / Jennifer L. Weinberg -- 17. Feet of Clay: The Impaired Dermatologist / Brandon H. Krupp -- Part III. Dermatologist as Teacher and Trainee -- 18. The Mentor-Mentee Relationship: The Devil Is in the Details / Kimberly L. Merkel, John A. Cole, and Stanton K. Wesson -- 19. Tales from the Residency Interview Trail / Jennifer A. Sbicca and Alfred T. Lane -- 20. Ethics Education for Residents: Growing Pains and Learning Crises / Irèn Kossintseva and Benjamin Barankin -- 21. Teaching Ethics in Clinic: Keeping You Smart and Honest / Nely Z. Aldrich and Eliot N. Mostow -- Part IV. Dermatologist as Businessperson -- 22. Boutiques, Botox®, and Basal Cells: Can Dermatology Set Its Priorities? / Jeffrey J. Meffert and Maria Villegas -- 23. The Price Is Right: Office Dispensing and Product Pricing / Tivon Sidorsky -- 24. My Elixir, MD: Morphing a Medical Degree into a Skincare Brand / Julie Cantor -- 25. Marketing the Physician: From Antitrust to Distrust / Catherine L. Kowalewski and Jeffrey J. Meffert -- 26. What the Market Will Bear? Ethical and Professional Issues in Medical Fees / Carl Johnson and Lionel Bercovitch -- 27. Spa, MD: When Dermatology Meets Aromatherapy / Tivon Sidorsky and Lionel Bercovitch -- 28. Gatekeepers, Dermatologists, and Their Patients: Mixed Messages in Managed Care / Lindsey A. Brodell, Robert T. Brodell, and Brendan Minogue -- 29. Ethical Adventures in 21st Century Dermatopathology / Homer O. Wiland IV, Barry D. Kels, and Jane Grant-Kels -- 30. Defining the Gray Zone: Client Billing and Contractual Joint Ventures / Homer O. Wiland IV, Barry D. Kels, and Jane Grant-Kels -- 31. No Strings Attached? Managing Conflicts of Interest in Medicine / Noah D. Shannon and Clifford Perlis -- Part V Dermatologist as Scholar -- 32. Respecting Human Subjects: Responsibilities of the Clinical Investigator / Kenneth Katz and Samual Garner -- 33. Hope, Hype, and Genotype: Genetic Testing in Dermatological Diseases / Natasha Shur -- 34. Desperate Measures for Desperate Patients: Translational Research in Epidermolysis Bullosa / Alfred T. Lane -- 35. Reading Between the Lines: Can Peer Reviewers Be Expected to Detect Fraud? / Jason D. Gillum, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 36. Hiding Behind the Curtain: Anonomyous Versus Open Peer Review / Andrea L. Suárez, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 37. Ghost Busting in Dermatology Publications: Providing Byline Integrity / Andrea L. Suárez, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 38. Telling the Same Tale Twice: Déjà vu and the Shades of Grey in Self-Plagiarism / Andrea L. Suárez, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 39. Cutting Edge or Cutting Corners? Innovative Care / Jolion McGreevy and Clifford Perlis.
  • 2011 CRCnetBASE
    Murthy, S. Narasimha.
    "Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, is imperfect, and may allow certain topically applied substances or toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of nature of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover the introductory aspects significance, methods, and models used in dermatokinetic studies of therapeutic agents.Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents; Drug Delivery Approaches to Modulate Dermatokinetics of Drugs; Conventional Methods of Cutaneous Drug Sampling; Cutaneous Microdialysis; Sampling Substrates by Skin Permeabilization; Spectroscopic Techniques in Dermatokinetics Studies; Regulatory Perspective of Dermatokinetic Studies"--Provided by publisher.
  • 2012 ClinicalKey
    Usatine, Richard.
    Drs. Richard Usatine, John Pfenninger, Daniel Stulberg, and Rebecca Small, provides you with the clear, step-by-step guidance you need to provide these options to your patients. Full-color photographs and drawings in combination with high-definition narrated videos clearly demonstrate key procedures, including skin biopsies, cryosurgery, electrosurgery, botulinum toxin injections, and more. Incorporate key dermatologic and cosmetic procedures into your practice with coverage of using dermoscopy to more accurately detect skin cancer, the latest information on lasers, botulinum toxin injections and dermal fillers, the diagnosis and treatment of benign and malignant lesions, and more. Master dermatologic and cosmetic procedures thanks to more than 40 narrated, high-definition videos on DVD, demonstrating skin biopsies, cryosurgery, electrosurgery, and excision of skin cancers, cysts, and lipomas. See how to perform each procedure clearly from detailed, full-color photographs and drawings and step-by-step instructions. Maximize the value of providing dermatologic and cosmetic procedures with guidance on combination treatments as well as coding and billing details. Enhance your practice with step-by-step guidance to perform virtually any skin procedure in the office setting.
  • 2010 Springer
    Cuyper, Christa de; Pérez-Cotapos S, M. Luisa.
  • 2008 Karger
    Nestle, F. O.; Nickoloff, Brian J.
    Allergic contact dermatitis / M.D. Gober, A.A. Gaspari -- Immune privilege and the skin / T. Ito ... [et al.] -- Immunobiology of acute cytotoxic drug reactions / B.J. Nickoloff -- Psoriasis / F.O. Nestle -- Atopic dermatitis in 2008 / L.S. Chan -- Cutaneous Lupus erythematosus : molecular and cellular basis of clinical findings / A. Kuhn, R. Sontheimer -- Bullous pemphigoid and related subepidermal autoimmune blistering diseases / E.B. Olasz, K.B. Yancey -- Pemphigus vulgaris and its active disease mouse model / M. Amagai -- Pemphigus foliaceus / D. Dasher, D. Rubenstein, L. Diaz -- Autoimmunity to type VII collagen : Epidermolysis bullosa acquisita / J. Remington ... [et al.] -- Pathomechanisms of Lichen planus autoimmunity elicited by cross-reactive T cells / T. Shiohara ... [et al.] -- Autoimmune etiology of generalized vitiligo / I.C. Le Poole, R.M. Luiten -- The genetics of generalized vitiligo / R.A. Spritz -- Scleroderma / A.C. Gilliam -- Alopecia areata / L.E. King Jr., K.J. McElwee, J.P. Sundberg -- Dermatomyositis / M.S. Krathen, D. Fiorentino, V.P. Werth -- Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses / D. Michael, S.A. Grando -- Skin involvement in systemic autoimmune diseases / S. Rashtak, M.R. Pittelkowo -- Therapeutics and immune-mediated skin disease / K.B. Gordon, R. Satoskar.
  • 2009 ClinicalKey
    Ammirati, Christie T.; Poblete-Lopez, Christine; Vidimos, Allison T.
    1, Surgical anatomy of the head and neck -- 2, Antisepsis -- 3, Local anesthetics -- 4. Surgical instruments -- 5. Preoperative evaluation of the dermatologic surgery patient -- 6. Cutaneous wound healing -- 7. Electrosurgery -- 8. Cryosurgery -- 9. Biopsy techniques -- 10. Basic excisional surgery -- 11. Suture techniques -- 12. Suture materials -- 13. Flaps -- 14. Skin grafts -- 15. Nail surgery -- 16. Mohs micrographic surgery -- 17. Surgical complications -- 18. Sclerotherapy of varicose and telangiectatic leg veins -- 19. Lasers: physics and medical indications -- 20. Photodynamic therapy.
    Also available: Print – 2009
  • 2013 Springer
    Jemec, G. B. E.; Wortsman, Ximena.
    This book is a comprehensive introduction to ultrasonography of the skin, nails, and scalp as it relates to the assessment and diagnosis of dermatologic diseases. It provides a concise understanding of the diagnosis of dermatologic conditions through extensive high-resolution gray scale and color Doppler ultrasound images and presents classical correlations of clinical dermatologic lesions with sonographic and histologic findings.
  • 2002 CRCnetBASE
    Walters, Kenneth A.
  • 2013 Karger
    Kimball, Alexa Boer; Linder, M. Dennis.
    Life span and life course approaches to dermatological disease / Ryff, C.D. -- Key concepts in the life course approach in medicine : allostatic load and cumulative life course impairment / Offidani, E.; Tomba, E.; Linder, M.D. -- Mathematical modeling in life course research / Barban, N.; Linder, M.D. -- Life course impairment and quality of life over time / Sampogna, F. -- Concept of major life-changing decisions in life course research / Bhatti, Z.U.; Salek, S.; Finlay, A.Y. -- Setting up a life course questionnaire / Sampogna, F. -- Cumulative life course impairment in chronic wounds / Augustin, M. -- Cumulative life course impairment : evidence for psoriasis / Mattei, P.L.; Corey, K.C.; Kimball, A.B. -- Cumulative life impairment by epidermolysis bullosa / Fine, J.-D. -- Cumulative life course impairment in vitiligo / Krüger, C.; Schallreuter, K.U. -- Cumulative life course impairment in melanoma and nonmelanoma skin cancer / Piaserico, S. -- Cumulative life course impairment : identifying patients at risk / Augustin, M. -- Cumulative life course impairment in dermatological diseases other than psoriasis : an overview / Ibler, K.S.; Jemec, G.B.E. -- Cumulative life course impairment across cultures and medical systems / Lima, X.T. -- Patients' narratives / Foulkes, A.C.; Warren, R.B.
  • 2015 Springer
    Lerma, Edgar V.; Nunley, Julia R.
    Genodermatoses / Erin L. Reese -- Metabolic disorders / Davida A. Kornreich -- Hepatitis viruses / Ivy I. Norris and Cindy England Owen -- Human immunodeficiency virus / Caroline Y. Winslow and Francisco A. Kerdel -- Rheumatologic conditions / Kseniya Golubets, Dan Ilkovitch, and Lisa M. Grandinetti -- Xerosis / Connie M. Wu, Annie M. Wu, Jenna Lester, and Leslie Robinson-Bostom -- Pruritus in chronic kidney disease / Ehsan Azimi, Ethan A. Lerner, and Sarina B. Elmariah -- Dyschromias in renal disease / Mwatsveruka N. Munhutu and Rebat M. Halder -- Calcinosis cutis / Mitalee P. Christman and Daniela Kroshinsky -- Calciphylaxis / Julio C. Sartori-Valinotti and Mark Davis -- Acquired perforating disorders / Mieke L.F. Flour and Dirk R.J. Kuypers -- Nephrogenic systemic fibrosis / Avery LaChance, Ali K. Abu-Alfa, and Shawn E. Cowper -- Blistering disorders (Porphyria cutanea tarda and Pseudoporphyria) / Christine A. DeWitt, Kara M. Trapp, and Melissa A. Muszynski -- Nail diseases among renal patients / Avner Shemer, Nicole Sakka, and C. Ralph Daniel III -- Alopecias / Kimberly Scott Salkey -- Uremic frost / Kristie Lynn Slivka Delaney, Edgar V. Lerma, and Julia R. Nunley -- Infections in the kidney transplant recipient / James D. Russell and Calvin O. McCall -- Cutaneous malignancies / Melina B. Chu, Brandon T. Beal, and Ian A. Maher -- Miscellaneous drug related adverse effects / Punam H. Patel and Krista L. Donohoe -- Drug dosing in patients with chronic kidney disease and dermatological diseases / Ali J. Olyaei and Edgar V. Lerma.
  • 2009 Springer
    Elmets, Craig A.; Hönigsmann, H.; Krutmann, Jean.
  • 2009 ClinicalKey
    Bolognia, Jean L.; Callen, Jeffrey P.; Jorizzo, Joseph L.
    1. Lupus erythematosus / Christopher B. Hansen, Jeffrey P. Callen -- 2. Dermatomyositis / Ruth Ann Vleugels, Jeffrey P. Callen -- 3. Scleroderma, Raynaud's phenomenon, and related conditions / Susannah E. McClain ... [et al.] -- 4. Vasculitis / Jeffrey P. Zwerner, Jeffrey P. Callen, David F. Fiorentino -- 5. Miscellaneous disorders with prominent features involving the skin and the joints / Brad A. Yentzer ... [et al.] -- 6. Urticaria / Andrew D. Lee, Joseph L. Jorizzo -- 7. Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis / B. Asher Louden, Joseph L. Jorizzo -- 8. Erythema nodosum and other panniculitides / Manisha J. Patel, Joseph L. Jorizzo, Jeffrey P. Callen -- 9. Pruritus / Gil Yosipovitch -- 10. Erythroderma / Aaron M. Loyd, Joseph L. Jorizzo -- 11. Purpura / Warren W. Piette -- 12. Bullous diseases / Anneli R. Bowen, John J. Zone -- 13. Skin signs of internal malignancy / Edward W. Cowen, Jeffrey P. Callen -- 14. Metastatic disease / Warren W. Piette -- 15. Cutaneous manifestations of leukemias, myelodysplasti and myeloproliferative syndromes, and systemic lymphomas / Warren W. Piette -- 16. Dysproteinemias, plasma cell disorders, and amyloidosis / Warren W. Piette -- 17. Cutaneous manifestations of macrophage/dendritic cell proliferative disorders (histiocytoses) / Warren W. Piette -- 18. Vascular neoplasms / Julie V. Schaffer, Jean L. Bolognia -- 19. Primary cutaneous T-cell and B-cell lymphomas / Gary S. Wood, Warren W. Piette -- 20. Diabetes mellitus / Mohammad Reza Namazi, Gil Yosipovitch -- 21. Thyroid and the skin / Warren R. Heymann, Ted Rosen, Joseph L. Jorizzo -- 22. Lipids / Sarah L. Taylor, Kenneth E. Greer, Joseph L. Jorizzo -- 23. Adrenal, androgen-related, and pituitary disorders / Drew W. Miller, Steven R. Feldman, Joseph L. Jorizzo -- 24. Porphyrias / Julia R. Nunley, Marc E. Grossman, Warfen W. Piette -- 25. Cutaneous diseases associated with gastrointestinal abnormalities / Mark D. Herron, John J. Zone -- 26. Cutaneous hepatology / J. Mark Jackson, Jeffrey P. Callen, Kenneth E. Greer -- 27. Pancreatic disease / Daniel J. Pearce, Kenneth E. Greer, Joseph L. Jorizzo -- 28. Cutaneous manifestations of systemic viral, bacterial, and fungal infections and protozoan disease / Christina Haverstock ... [et al.] -- 29. Acquired immunodeficiency syndrome and sexually transmitted infections / Jean L. Bolognia -- 30. Sarcoidosis / Joseph C. English III, Jeffrey P. Callen -- 31. Cardiovascular diseases and the skin / Kathryn Schwarzenberger, Jeffrey P. Callen -- 32. Renal disease and the skin / Cheryl L. Lonergan, Thomas G. Cropley -- 33. Manifestations in transplant recipients / Dennis L. Cooper, Jean L. Bolgnia -- 34. Neurocutaneous disease / Clive M. Liu, John J. Zone -- 35. Pregancy / Lisa M. Cohen, George Kroumpouzos -- 36. Mast cell disease / Michael D. Tharp -- 37. Hair disorders in systemic disease / Raechele C. Gathers, Amy J. McMichael -- 38. Nail signs of systemic disease / Christopher B. Yelverton, Joseph L. Jorizzo -- 39. Oral mucous membranes and systemic disease / Charles Camisa, Jeffrey P. Callen -- 40. Leg ulcerations / Mark D.P. Davis -- 41. Cutaneous drug eruptions / Susan Burgin, Stephen E. Wolverton, Jeffrey P. Callen -- 42. Systemic therapy for cutaneous disease / Stephen E. Wolverton, Jeffrey P. Callen.
    Also available: Print – 2009
  • v. 1, 1971.
    Fahs, Ivan J.; Lynch, Francis W.
    PrintStatus: Not Checked OutLane Catalog Record
    Contents. - pt. 1. A study of health manpower resources, 1963-1970.
  • 2006 Thieme Book
    Sterry, Wolfram; Burgdorf, Walter H. C.; Paus, Ralf.
    Anogenital diseases -- Phlebology -- Occupational dermatoses -- Skin diseases in different age groups -- Psychodermatology -- Topical therapy -- Systemic therapy -- Radiation therapy -- Therapy during pregnancy and nursing -- Operative dermatology -- Wound healing -- Dermatologic emergencies. Introduction to skin biology -- Dermatologic diagnosis -- Other diagnostic methods -- Viral diseases -- Bacterial diseases -- Fungal diseases -- Other infectious diseases -- Sexually transmitted diseases -- HIV infection and AIDS -- Allergic diseases -- Drug reactions -- Dermatitis -- Collagen vascular disorders -- Autoimmune bullous diseases -- Purpura and vasculitis -- Papulosquamous disorders -- Granulomatous and necrobiotic disorders -- Dermatoses caused by physical and chemical agents -- Metabolic diseases -- Pruritus and prurigo -- Genodermatoses -- Disorders of pigmentation -- Melanocytic tumors -- Cysts and epidermal tumors -- Adnexal tumors -- Soft tissue tumors -- Other cutaneous tumors -- Cutaneous lymphomas and leukemia -- Paraneoplastic disorders -- Diseases of the lips and oral mucosa -- Diseases of the hairs and scalp -- Diseases of the nails -- Disorders of sweat glands -- Diseases of sebaceous glands -- Diseases of subcutaneous fat --
  • 2012 Springer
    Jain, Sima.
    Basic Science and Immunology -- Pediatric Dermatology -- General Dermatology -- Infectious Diseases -- Benign and Malignant Tumors -- Dermatologic Surgery -- Pharmacology and Drug Reactions -- Pathology -- Dermoscopy and Electron Microscopy -- Life After Boards -- High Yield Facts and Buzz Words.
  • 2012 ClinicalKey
    Gawkrodger, D. J.; Ardern-Jones, Michael R.
    Machine generated contents note: Basic principles -- Microanatomy of the skin -- Derivatives of the skin -- Physiology of the skin -- Biochemistry of the skin -- Immunology of the skin -- Molecular genetics and the skin -- Terminology of skin lesions -- Taking a history -- Examining the skin -- Practical clinic procedures -- Basics of medical therapy -- Epidemiology of skin disease -- Body image, the psyche and the skin -- Diseases -- Eruptions -- Psoriasis -- epidemiology, pathophysiology and presentation -- Psoriasis -- management and complications -- Psoriasis -- biologics -- Eczema -- basic principles/contact dermatitis -- Eczema -- atopic eczema -- Eczema -- other forms -- Lichenoid eruptions -- Papulosquamous eruptions -- Erythroderma -- Photodermatology -- Infections -- Bacterial infection -- staphylococcal and streptococcal -- Other bacterial infections -- Viral infections -- warts and other viral infections -- Viral infections -- herpes simplex and herpes zoster
  • 2006
    Halder, Rebat M.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 Springer
    Jackson-Richards, Diane; Pandya, Amit G.
    This atlas, containing more than 300 color photos, focuses on those dermatologic conditions that are most common in ethnic skin or skin of color. It includes succinct explanations of each disease process, describes clinical findings, and presents key information on diagnosis and treatment. Individual chapters are devoted to pigmentary disorders, follicular disorders, hair and scalp disorders, eczemas, papulosquamous disorders, granulomatous disorders, connective tissue diseases, infectious diseases, scarring disorders, cutaneous neoplasms, photodermatoses and drug eruptions. The fact that this atlas covers skin disorders that affect patients of all ethnic backgrounds ensures that it will be of worldwide relevance. It will serve as a valuable reference for dermatologists and a range of other health care providers.
  • 2014 ClinicalKey
    Bolognia, Jean L.
    Dermatology Essentials, edited by world authorities Drs. Jean L. Bolognia, Julie V. Schaffer, Karynne O. Duncan, and Christine J. Ko, provides the quick answers you need on every important aspect of dermatology and guidance on their application in your day-to-day practice. Derived from the renowned authoritative reference work Dermatology, 3rd Edition, this on-the-go reference distills the essential information needed to quickly diagnose and manage a wide range of dermatologic disorders-without the need for any additional resources. Review or refresh your knowledge of the fundamentals and diagnostic approaches of skin disease with unique introductory chapters providing the basic principles of dermatology, bedside diagnostics, and clinical approach to a fever and rash - extremely helpful for the beginner. Visualize more of the conditions you see in practice with over 1,500 clinical images, illustrations, and schematics. Avoid diagnostic pitfalls using practical tables, intuitive artworks, and logical algorithms. Find answers fast with a highly user-friendly, "easy-in-easy-out" format and a wealth of tables and schematics for instant visual comprehension. Expedite decision making with easily recognizable DDx and Rx sections to provide rapid direct reference to the expert guidance and treatment recommendations. Downloadable worksheets are also available. Make the most of electronic functionality with access to the complete contents online and in various ebook formats - making it easy to teach impromptu on a tablet in the clinic, or conduct more formal lecturing.
  • 2010 Springer
    Zaidi, Zohra; Lanigan, Sean W.
    Skin: structure and function -- Immune system of the skin -- Diagnosis of skin disease -- Bacterial infections -- Superficial fungal infections -- Viral infections -- Parasitic infestations and diseases caused by arthropods -- Eczema -- Keratinizing and papulosquamous disorders -- Diseases of connective tissue -- Bullous disorders: autoimmune and childhood bullous dermatoses -- Vasculitis, common erythemas, and lymphatic disorders -- Exanthems and hypersensitivity syndromes -- Urticaria -- Pruritus -- Leg ulcers -- Disorders of pigmentation Disorders of ultraviolet radiation and injuries due to cold -- Diseases of the sebaceous, sweat, and apocrine glands -- Hair disorders -- Nail disorders -- Diseases of the subcutaneous tissue -- Tumors of the skin -- Naevi and hereditary diseases of the skin -- Skin and malnutrition -- Skin and systemic disease -- Skin and the psyche -- Erythroderma -- Ages of man and their dermatoses -- Diseases of the oral cavity -- Diseases of the external genitalia -- Miscellaneous disorders -- Drug reactions -- Management of skin diseases.
  • v. 1-2, 2008.
    Bolognia, Jean L.; Jorizzo, Joseph L.; Rapini, Ronald P.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 ClinicalKey
    Bolognia, Jean L.; Jorizzo, Joseph L.; Schaffer, Julie V.
    "Dermatology, edited by world authorities Jean L. Bolognia, MD, Joseph L. Jorizzo, MD, and Julie V. Schaffer, MD, is an all-encompassing medical reference book that puts the latest practices in dermatologic diagnosis and treatment at your fingertips. It delivers more comprehensive coverage of basic science, clinical practice, pediatric dermatology, and dermatologic surgery than you'll find in any other source. Whether you're a resident or an experienced practitioner, you'll have the in-depth, expert, up-to-the-minute answers you need to overcome any challenge you face in practice."--Publisher's website.
  • 2007
    Fitzpatrick, James E.; Morelli, Joseph G.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2016 Springer
    Lipoff, Jules.
  • 2006 Springer
    Trozak, Daniel J.; Russell, John J.; Tennenhouse, Dan J.
    Specific history -- Dermatologic physical examination -- Indicated supporting diagnostic data -- Therapy -- Molluscum contagiosum (dimple warts) -- Verruca vulgaris (common warts) -- Seborrheic dermatitis (dandruff) -- Pityriasis rosea -- Psoriasis vulgaris -- Lichen planus -- Miliaria rubra (prickly heat) -- Scabies -- Erythrasma -- Tinea (superficial fungi, dermatophytosis, ringworm) -- Urticaria (urticaria simplex, common hives) -- Fixed drug eruption -- Erysipelas/cellulitis -- Erythema multiforme -- Lupus erythematosus -- Toxicodendron dermatitis (poison oak, poison ivy, poison sumac; also known as Rhus dermatitis) -- Atopic dermatitis (atopic eczema, disseminated neurodermatitis -- Besnier's prurigo) -- Asteatotic eczema (xerosis, xerotic eczema, eczema craquelé, eczema cannalé, eczema hiemalis, winter itch) -- Senile purpura (Bateman's purpura) -- Striae distensae (striae atrophicans, striae gravidarum, stretch marks) -- Seborrheic keratosis (old age spots, liver spots) -- Ephelides (freckles) -- Lentigines -- Melanocytic nevi -- Malignant melanoma -- Actinic keratosis (solar keratosis) -- Keratoacanthoma (molluscum sebaceum) -- Common skin cancers -- Impetigo (impetigo contagiosa) -- Herpes simplex recidivans (herpes labialis, cold sores, fever blisters Herpes genitalis) -- Herpes zoster (shingles) -- Acne vulgaris (acne, zits) -- Rosacea (acne rosasea).
  • 2010 Springer
    Allen, Herbert B.
    Papulosquamous Diseases / Herbert B. Allen -- Vesiculobullous Disorders (Including Dermatitis/Eczema) / Herbert B. Allen -- Infectious Diseases / Herbert B. Allen -- Hypersensitivity Disorders / Herbert B. Allen -- Genetic Diseases / Herbert B. Allen -- Dermatology in Systemic Disease / Herbert B. Allen -- Tumors / Herbert B. Allen -- Miscellaneous Disorders / Herbert B. Allen.
  • 2009 Springer
    Dourmishev, Lyubomir A.; Durmishev, Assen.
  • 2010 Springer
    Kempf, Werner.
  • 2011 ClinicalKey
    Brinster, Nooshin K.
    Part of the High-Yield Pathology Series, this title is designed to help you review the key pathologic features of skin disease, recognize the classic look of each disease, and quickly confirm your diagnosis. Its templated format, excellent color photographs, concise bulleted text, and authoritative content, will help you accurately identify more than 400 skin conditions. Find information quickly and easily with a templated, easy-to-reference format. Confirm your diagnoses with excellent color photographs that demonstrate the classic appearance of each disease. Find the answers you need fast with concise bulleted text. Depend on authoritative information from leading experts in the field.
  • 2006 Springer
    Brehmer-Andersson, Eva.
    1. Requirements for a Good Diagnostic Result, p. 1-3 -- 2. The Dermal Blood Vasculature, p. 4-8 -- 3. The Dermal Lymphatic Vasculature, p. 9-11 -- 4. The Immune Response, p. 12-20 -- 5. Cell and Vascular Response to Infection and Injury, p. 1-30 -- 6. Cell Death in the Living Body, p. 31-34 -- 7. Vasculitis, p. 35-64 -- 8. Skin Lesions due to Abnormalities in Blood Components, p. 65-74 -- 9. Arteriosclerosis in the Skin, p. 75-77 -- 10. Thromboangiitis Obliterans, p. 78-79 -- 11. Angiotropic Lymphoma, p. 80-82 -- 12. Infections Caused by Common Pyogenic Bacteria, p. 83-85 -- 13. Common Fungal Infections, p. 86-99 -- 14. Demodicidosis, p. 100-101 -- 15. Infections Caused by Mycobacterium Tuberculosis, M. Bovis, and Atypical Mycobacteria, p. 102-109 -- 16. Leprosy, p. 110-113 -- 17. Syphilis, p. 114-121-- 18. Lyme Borreliosis, p. 122-133 -- 19. Leishmaniasis, p. 134-135 -- 20. Herpes Simplex, Herpes Zoster/Varicella, and Cytomegalovirus Infections, p. 136-146 -- 21. Langerhans Cell Histiocytosis in Skin and Mucous Membranes, p. 147-154 -- 22. Dermatitis (Eczema), p. 155-162 -- 23. Psoriasis, p. 163-169 -- 24. Lichen Planus and Lichen Nitidus, p. 170-175 -- 25. Autoimmune Vesicular, Bullous, and Pustular Dermatoses, p. 176-198 -- 26. Recurrent Vesicular Eruptions, p. 199-209 -- 27. Profiles of the Epidermal/Dermal Area in some Vesicular/Bullous Dermatoses, p. 210-213 -- 28. Skin Lesions Due to Drugs, p. 214-230 -- 29. Artifacts, p. 231-244.
    Also available: Print – 2006
  • 2013 Springer
    Zappi, Eduardo; Zappi, Eduardo A.
    Elements of Cutaneous Embryology, Anatomy, and Biochemistry -- Classification of Cutaneous Lesions -- Hereditary Lesions -- Malformative Lesions -- Inflammatory Cutaneous Lesions -- Proliferative Cutaneous Lesions -- Miscellaneous Cutaneous Lesions.
  • 2014 Springer
    Cockerell, Clay J.
    With significant progress as new techniques to evaluate the pathology of the skin, this book satisfies the need to provide practical clinical information and concise criteria for pathologic diagnosis for pathologists and dermatologists looking for an up-to-date resource. This superb visual reference provides detailed instruction of the experience of both diagnostic pathology and clinical dermatology. Dermatopathology: Clinicopathological Correlations is a comprehensive but concise visual reference that contains specific features on the various clinical findings and histologic findings of skin diseases. It emphasizes criteria for diagnosis to help the trainee pathologist or dermatologist decipher the most important features and make clinical decisions quickly and effectively.
  • 2009 Springer
    Smoller, Bruce; Hiatt, Kim M.
  • 2010
    Barnhill, Raymond L.; Crowson, A. Neil; Magro, Cynthia M.; Piepkorn, Michael.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 ClinicalKey
    Elston, Dirk M.; Ferringer, Tammie.
    New to this edition: Recognize the presentation of most major dermatopathology lesions through abundant high-resolution histopathology examples, with labels and pointers highlighting key aspects of each slide and providing additional clarity. Including 26 lectures by Dr. Elston, clinical and dermatopathology image atlases, and a virtual slide library. Easily focus on the most important "takeaways" and "must-knows" for each topic through the use of color key points, differential diagnosis, and pearls.
  • 2016 ClinicalKey
    Busam, Klaus J.
    Inflammatory disease of the dermis and epidermis / Maxwell A. Fung -- Panniculitis / Maxwell A. Fung -- Infectious diseases of the skin / Helen M. Chen, Anca G. Prundeanu Croitoru, Stefanie Hu, Hideko Kamino, Marcia Ramos-e-Silva, Klaus J. Busam -- Cutaneous vasculitis / Rami N. Al-Rohil, J. Andrew Carlson -- Blistering skin diseases / Jacqueline M. Junkins-Hopkins, Klaus J. Busam -- Mucinoses, deposition disorders, and connective tissue alterations / Franco Rongioletti, Jacqueline Granese, Jacqueline Junkins-Hopkins, Luis Requena -- Non-neoplastic disorders of pigmentation / Ravi Ubriani, Loren E. Clarke, Michael E. Ming -- Non-neoplastic disorders of hair / Klaus Sellheyer, Wilma F. Bergfeld -- Cysts and sinuses / Douglas R. Fullen -- Tumors of the epidermis / Angela J. Wyatt, Klaus J. Busam -- Adnexal tumors / Victor G. Prieto, Christopher R. Shea, Julide Tok Celebi, Klaus J. Busam -- Melanocytic proliferations / Klaus J. Busam -- Soft tissue tumors and tumor-like reactions / Darya Buehler, Steven D. Billings -- Hematopoietic neoplasms / Jacqueline M. Junkins-Hopkins, Patricia L. Myskowski, Melissa P. Pulitzer -- Histiocytic proliferative disorders / Bijal Amin, Melissa P. Pulitzer, Klaus J. Busam -- Cutaneous neuroendocrine (Merkel cell) carcinoma / Bijal Amin, Klaus J. Busam -- Cutaneous metastases / Richard A. Scolyer, John F. Thompson, Annabelle Mahar, Rajmohan Murali -- Neoplastic and non-neoplastic disorders of the nail apparatus / Beth S. Ruben -- Neoplastic and non-neoplastic disorders of the conjunctiva and eyelid / Jasmine Francis, Klaus J. Busam, Brian Marr -- Evaluations of sections from Mohs surgery / Kishwer S. Nehal, Marie Tudisco, Klaus J. Busam.
  • 2010 ClinicalKey
    Busam, Klaus J.
    1. Inflammatory diseases of the dermis and epidermis / Maxwell A. Fung -- 2. Panniculitis / Neil Scott McNutt, Maxwell A. Fung -- 3. Infectious diseases of the skin / Anca G. Prundeanu Croitoru ... [et al.] -- 4. Cutaneous vasculitis / J. Andrew Carlson -- 5. Blistering skin diseases / Jacqueline M. Junkins-Hopkins, Klaus J. Busam -- 6. Deposition disorders and miscellaneous alterations of dermal connective tissue / Franco Rongioletti, Jacqueline Granese, Jacqueline M. Junkins-Hopkins -- 7. Non-neoplastic disorders of pigmentation / Ravi Ubriani, Loren E. Clarke, Michael E. Ming -- 8. Non-neoplastic disorders of hair / Klaus Sellheyer, Wilma F. Bergfeld -- 9. Cysts and sinuses / Douglas R. Fullen -- 10. Tumors of the epidermis / Angela J. Wyatt, Klaus J. Busam -- 11. Adnexal tumors / Victor G. Prieto ... [et al.] -- 12. Melanocytic proliferations / Klaus J. Busam -- 13. Soft tissue tumors and tumor-like reactions / Steven D. Billings, John R. Goldblum -- 14. Hematopoietic neoplasms / Jacqueline M. Junkins-Hopkins, Patricia L. Myskowski, Klaus J. Busam -- 15. Histiocytic proliferative disorders / Bijal Amin, Melissa Pulitzer -- 16. Cutaneous nueroendocrine (Merkel cell) carcinoma / Bijal Amin, Klaus J. Busam -- 17. Cutaneous metastases / Richard A. Scolyer, Rajmohan Murali, John F. Thompson.
    Also available: Print – 2010
  • 1974-
    Jarrett, A.; Ryan, Terence J.; Sinclair, David Cecil.
  • 2012 ClinicalKey
    Soyer, H. Peter.
    Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all aspects of performing dermoscopy and interpreting results. With approximately 50% new clinical and dermoscopic images, valuable pearls and checklists, and you'll have everything you need to diagnose earlier and more accurately. Diagnose more accurately using the expanded section on testing tools for extra guidance on difficult cases. Gain a better visual understanding with approximately 50% new clinical and dermoscopic images that depict the appearance of benign and malignant lesions and feature arrows and labels to highlight important manifestations. Get better diagnostic results for less by learning how to successfully perform dermoscopy with this portable, to-the-point resource.
  • Google Books
    Bergeret, Louis François Etienne.
    Also available: Print – 5. éd., 1877.
  • 2001 CRCnetBASE
    Florka, Roger.
  • 2007
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 CRCnetBASE
    Chow, Shein-Chung; Liu, Jen-pei.
    Design of bioavailability studies -- Statistical inferences for effects from a standard 2x2 crossover design -- Statistical methods for average bioequivalence -- Power and sample size determination -- Transformation and analysis of individual subject ratios -- Assessment of inter- and intra-subject variabilities -- Assumptions of outlier detection for average bioequivalence -- Optimal crossover designs for two formulations for average bioequivalence -- Assessment of bioequivalence for more than two formulations -- Population and individual bioequivalence -- Statistical procedures for assessment of population and individual bioequivalence -- Assessment of bioequivalence for drugs with negligible plasma levels -- In vitro bioequivalence testing -- In vitro dissolution profiles comparison -- Meta-analysis for bioequivalence review -- Population pharmacokinetics -- Other pharmacokinetic studies -- Review of regulatory guidances on bioequivalence -- Frequently asked questions and future challenges.
  • 2009 CRCnetBASE
    Peace, Karl E.
    Overview of time-to-event endpoint methodology / Karl E. Peace -- Design (and monitoring) of clinical trials with time-to-event endpoints / Michael W. Sill and Larry Rubinstein -- Overview of time-to-event parametric methods / Karl E. Peace and Kao-Tai Tsai -- Overview of semiparametric inferential methods for time-to-event endpoints / Jianween Cai and Donglin Zeng -- Overview of inferential methods for categorical time-to-event data / Eric V. Slud -- Overview of Bayesian inferential methods including time-to-event endpoints / Laura H. Gunn -- An efficient alternative to the Cox model for small time-to-event trials / Devan V. Mehrotra and Arthur J. Roth -- Estimation and testing for change in hazard for time-to-event endpoints / Rafia Bhore and Mohammad Huque -- Overview of descriptive and graphical methods for time-to-event data / Michael O'Connell and Bob Treder -- Design and analysis of analgesic trials / Akiko Okamoto, Julia Wang, and Surya Mohanty -- Design and analysis of analgesic trials with paired time-to-event endpoints / Zhu Wang and Hon Keung Tony Ng -- Time-to-event endpoint methods in antibiotic trials / Karl E. Peace -- Design and analysis of cardiovascular prevention trials / Michelle McNabb and Andreas Sashegyi -- Design and analysis of antiviral trials / Anthony C. Segreti and Lynn P. Dix -- Cure rate models with applications to melanoma and prostate cancer data / Ming-Hui Chen and Sungduk Kim -- Parametric likelihoods for multiple nonfatal competing risks and death, with application to cancer data / Peter F. Thall and Xuemei Wang -- Design, summarization, analysis, and interpretation of cancer prevention trials / Matthew C. Somerville, Jennifer B. Shannon, and Timothy H. Wilson -- LASSO method in variable selection for right-censored time-to-event data with application to astrocytoma brain tumor and chronic myelogonous leukemia / Lili Yu and Dennis Pearl -- Selecting optimal treatments based on predictive factors / Eric C. Polley and Mark J. van der Laan -- Application of time-to-event methods in the assessment of safety in clinical trials / Kelly L. Moore and Mark J. van der Laan -- Design and analysis of chronic carcinogenicity studies of pharmaceuticals in rodents / Mohammad Atiar Rahman and Karl K. Lin -- Design and analysis of time-to-tumor response in animal studies : a Bayesian perspective / Steve Thomson and Karl K. Lin.
  • 2010 CRCnetBASE
    Fairclough, Diane Lynn.
    Using SAS, SPSS, and R, this book addresses design and analysis aspects in enough detail so that readers can apply statistical methods to their own longitudinal studies. This edition includes a new chapter on testing models that involve moderation and mediation, a new chapter on QALYs and QTWiST specific to clinical trials, and recent methodological developments for the analysis of trials with missing data. It also presents revised discussions of multiple comparisons procedures that focus on the integration of HRQoL outcomes with other study outcomes using gatekeeper strategies.
  • 2013
    Aukes, Daniel McConnell; Cutkosky, Mark R.; Khatib, Oussama; Mitiguy, Paul.
    A balance between complexity and functional capabilities has been explored since the first years of multi-fingered robotic hands. In an age where DC motors are the de facto standard for actuation in robotics, the problem of needing to operate in a human-sized world puts severe constraints and limits on actuator size and placement in hands. While many successful examples of fully-actuated designs exist, these designs generally reflect the trade-offs and sacrifices imposed by such constraints. In that light, underactuation, employing fewer actuators than degrees of freedom, has gained attention as a method to achieve many of the functional capabilities of fully-actuated hands with fewer constraints on actuators and transmissions. Underactuated hands also have distinct advantages over fully actuated hands, especially when used on mobile robots, due to their reduced weight and control complexity, and the potential for increased robustness. However there is typically a trade-off in terms of reduced controllability or manipulability when handling grasped objects. When designing underactuated hands, extra care must be taken during the design process to ensure that such hands will grasp a wide range of object sizes and shapes robustly, particularly when friction is low and uncertain. Despite these concerns, underactuated hands have become increasingly popular in robotic and prosthetic applications. Robotic hands are also a venue in which novel, secondary mechanisms are often found. Devices such as differentials, valves, clutches, and low-power, shape-changing actuators have been used to improve grasp robustness on a wider range of objects and allow users more grasping and manipulation options. However, the location and placement of secondary actuators has not been studied in a comprehensive way with respect to the types of actuation methods possible. This is due in part to the lack of general analytic tools which enable designers to rapidly investigate their designs prior to the prototyping stage. Additionally, much of the analysis in the field of robotic hands is done once basic design choices have already been made, making subsequent analyses specific only to a set of design parameters specific to those choices. The same point can be made regarding quality metrics, which suffer from fragmented utilization due to the many different emphases placed on different design requirements. The primary goal of this thesis is to provide a framework for the analysis and evaluation of underactuated robotic hands. The first chapter discusses both the broad motivations for studying robotic hands and the specific contributions of this thesis. The next chapter reviews relevant designs from literature, analyses that have accompanied them, uses of secondary devices in underactuated hands, and the progress that dynamics simulators have made towards representing reality. In the next chapters, the issues related to modeling abstract, generic hand designs is discussed, and a kinematic framework is introduced to derive the force relationships between actuator and grasped object for many mechanisms commonly encountered in underactuated hands. Chapter 6 discusses difficulties associated with solving static force equations, and several methods are introduced to accomplish this. The last of these options relies on three-dimensional rigid-body dynamic simulations to evaluate the performance of compliant, underactuated mechanisms which may encounter conditions such as coulomb friction in contact and and damping at the joints. In the next chapters, these force relationships are derived and discussed for specific hand designs in the context of a force-field representation, and several performance metrics are derived which measure a hand's ability both to acquire and retain objects. The benefits of secondary actuation mechanisms are then discussed with two specific examples. First is the SRI/Stanford/Meka hand, a tendon-driven, compliant, underactuated hand capable of locking individual joints. Second is a mechanism implemented on the Seabed Hand, which increases the range of graspable objects and allows users to selectively change grasp properties based on their specific control needs. Finally, the impacts of friction are discussed, and the trends from simulations are compared with experimental data. From these experiments the benefits of secondary mechanisms can be demonstrated in a frictional world as well.
  • Botman, Steven L.
  • 2012
    Zhang, Ruixiang; Khatib, Oussama; Latombe, Jean-Claude; Salisbury, J. Kenneth.
    This dissertation describes the design, implementation, and experimentation of an autonomous free-climbing robot, Capuchin. The objective of our project is to create a multi-limbed robot capable of climbing vertical terrain autonomously using techniques similar to those used by human free climbers. When a "free" climber climbs a steep crag or an artificial climbing wall, she uses nothing else but her hands and feet to make contact with terrain features such as holes, cracks, ledges or protrusions. Unlike "aid" climbing, which uses special equipments, tools, or engineered features, free climbing only relies on friction at the contacts between the climber and the terrain. In order to make a multi-limbed robot climb in a similar way, four fundamental challenges must be addressed: robot design, sensing, motion planning and motion control. Our work focuses on robot design (including sensors) and motion control. However, our robot, Capuchin, is an integrated system including a simplified sensing system and a pre-existing motion planner running off-line. A good robot design can increase the inherent ability of the robot to climb complex terrain. It may also lead to better performance and make other issues easier, such as motion planning and control. A four-limb structure was chosen after consideration of the robot's capability and complexity. Simulation was used during the design process to optimize performance, in particular to maximize the workspace reachable by the end-effectors (fingers). Sensors have been selected to allow the robot to both acquire information about the terrain and control its motion. Each finger is equipped with a camera. Vision feedback allows the robot controller to accurately dock the finger on a terrain feature at a location computed by the planner. It also allows modifying a planned trajectory in real-time, when the terrain differs slightly from the model that had been used by the planner or when other small errors occur (for instance, if the robot slips slightly at a contact). Each finger is additionally equipped with a force sensor that gives the magnitude and orientation of the reaction force at a contact. The four force sensors are used by the robot controller to maintain the robot in quasi-static equilibrium, by adjusting the robot posture and the joint torques when needed, so that the reaction forces at the contact point continuously within their Coulomb friction cones. A two-stage motion planner previously developed by Bretl and Hauser for free-climbing and other multi-limbed robots navigating on challenging and irregular terrain is used in this work. This planner decomposes a climbing motion into a sequence of moves, each performed with a fixed set of robot-terrain contacts (this set is called a "stance"). The transition at the end of each move consists of either breaking a contact or making a new one. The planner first computes a sequence of stances. Next it computes a trajectory for the move to be performed at each stance. If it fails to find a move at one step, it considers another sequence of stances. The core part of our research has been the design of the motion controller. The main problem we had to solve is a multi-contact force control problem. One of our most important findings has been the following: for quasi-static climbing, it is not necessary, even not desirable, to continuously control the forces exerted by the robot at the contact points. Instead, it is preferable to continuously monitor these forces and perform joint torque adjustments only when some reaction forces get too close to the boundaries of the friction cones or to their maximal magnitude. This strategy was not obvious when we started our research. In fact, we first developed a motion controller that continuously adjusted joint torques to keep measured reaction forces as close as possible to the terrain normals at the contact points. But computing these adjustments is rather time consuming. Moreover, this approach leads the robot to perform delicate adjustments frequently. As a result, robot motion was neither as smooth, nor as reliable as we would have liked. Instead, our new approach, which we call "lazy" force control, leads to a faster servo rate and much smoother motion. Our experiments show that on average adjustments only amount for a small percentage (less than 10%) of the total time spent climbing. They also demonstrate that Capuchin can reliably climb vertical artificial climbing walls autonomously and can handle small errors in the terrain model used by the planner.
  • 2014 ebrary
    Shepley, Mardelle McCuskey.
  • 2013
    Lillaney, Prasheel Vashdev; Fahrig, Rebecca; Pauly, John M.; Pelc, Norbert J.
    Using hybrid x-ray/MR (XMR) systems for image guidance during interventional procedures can enhance the diagnosis and treatment of neurologic, oncologic, cardiovascular, and other disorders. XMR suites have become more available, with various vendors offering dual-modality solutions. These systems combine the three-dimensional imaging capabilities and excellent soft tissue contrast provided by MR with the high spatial/temporal resolution and accurate device tracking provided by x-ray. To eliminate system compatibility concerns, the suites typically have long travel distances between MR and x-ray components. As a result, switching between modalities requires shuttling the patient several meters from one system to the other. Because patients typically have critically placed monitoring systems and intravenous lines for drug delivery and anesthesia, the cumbersome shuttling process impedes repeated switching between the modalities. To circumvent the hurdles associated with alternating between modalities, we proposed a close proximity hybrid system design in which a c-arm fluoroscopy unit is placed immediately adjacent to a closed bore MR system with a minimum distance of 1.2 meters between the x-ray and MR imaging field of views. Placing the x-ray system so close to the MR bore requires an x-ray tube capable of operating in a relatively strong MR fringe field environment. Existing rotating anode x-ray tube designs fail within MR fringe field environments because the magnetic fields alter the electron trajectories in the x-ray tube and act as a brake on the induction motor, reducing the rotation speed of the anode. In my work, I have developed (1) techniques to correct for the altered electron trajectories and (2) a novel motor design that eliminates the reduced rotation speed of the anode. Altering electron trajectories between the cathode and anode affects the location, size, and shape of the x-ray tube focal spot on the anode. I proposed a combination of approaches to control the trajectories. First, I derived an active magnetic shielding design using constrained optimization techniques that minimizes power consumption and heat deposition in the external deflection coils. I then adapted my shielding design to include rare earth permanent magnets, to further reduce the power and size requirements of the coils. Finally, I designed a split-focusing cup that controls the electron trajectories via electrostatic mechanisms, providing an alternative that is more space efficient and MR-compatible. High rotation speed of the anode is needed for sufficient instantaneous heat loading on the target area, to achieve the needed x-ray tube output. There is currently no available motor design to rotate the anode in the expected magnetic environment. To solve this problem, I designed a new motor that operates efficiently within the fringe field. The design is analogous to a modified three-pole brushed DC motor, with the radial component of the MR fringe field replacing the permanent magnet stator field used in conventional brushed DC motors. The motor support bearings provide rotating electrical contacts, while feedback signals from a position sensor control electrical commutation. A vacuum compatible prototype of the proposed motor design was assembled, and its performance was evaluated at various field strengths and orientations. Combining the control mechanisms for the electron trajectories with the new motor design yields a robust x-ray tube capable of operating in fringe fields with magnitudes on the order of 0.1 to 0.2 T.
  • 2012
    Jeong, Jaewoong; Contag, Christopher H.; Kino, Gordon S.; Solgaard, Olav.
    Optical MEMS (Micro-Electro-Mechanical Systems) is an enabling technology that realizes miniaturized optical systems with high functionality and excellent performance. In this dissertation, two novel miniaturized optical systems are presented for applications in optical communication and biomedical imaging. In Part I, a multi-functional MEMS tunable optical filter are described, which is a key element for dynamic wavelength provisioning in reconfigurable optical networks and communication systems. This filter is built based on MEMS platform technology that allows large vertical mirrors (311 [mu]m x 450 [mu]m x 40 [mu]m) to be micro-assembled on actuated platforms to enable compact tunable optical filters with large apertures and high-quality optical mirrors with very low scattering losses. Besides, electrostatic combdrive actuators connected to the MEMS platforms provide independent and continuous control of the center wavelength and the optical bandwidth. The filter has been tested by integrating it in a 10Gb/s communication system. The performance of the MEMS tunable filter is demonstrated for amplified spontaneous emission (ASE) rejection and wavelength selection. In PART II, a 3-D MEMS scanning system utilizing 2-D lateral and 1-D vertical MEMS scanners is introduced for use in miniature in vivo dual-axis confocal (DAC) microendoscopes, which is an emerging biomedical-imaging technology with high resolution, good tissue penetration, large field of view, and ability to provide both reflectance and fluorescence contrast images. Both MEMS scanners are fabricated exclusively by front-side processing to enable compact and robust structures that facilitate handling and packaging for miniaturized optical instrumentation. Co-operation of a 2-D lateral scanner and a 1-D vertical scanner enables fast 3-D microscopy over a volume that measures 340[mu]m by 236[mu]m by 286[mu]m. This part describes the principle of the all-MEMS-based 3-D scanning DAC microscopy that gives the functionality of OCT (real-time vertical cross-section imaging) to a confocal microscope.
  • 2012
    Csonka, Paul Janos Bela; Carryer, J. Edward; Kenny, Thomas W.; Waldron, Kenneth J.
    Over the last several years advances and miniaturization of technology have allowed legged robots to move from the research laboratory to the real world, as evidenced by the large number of flexible platforms only recently available. These platforms are successful, but fall short of capitalizing on the biggest advantage of legs: the ability for high speed locomotion over unstructured terrain. Additionally, no current articulated legged robot is able to perform both static and truly dynamic locomotion, as the actuation technology is not conducive to these two very different regimes of operation. Currently, machines that are dynamic are unable to walk or position themselves accurately, and machines that function very well with static motions are unable to move dynamically. The bipedal robot TRIP (Tendonized Running Inspired Platform) was built to study dynamic maneuvering and control of an articulated legged robot with high-inertia legs. Each leg includes an inelastic tendon which couples ankle joint rotations to knee joint rotations, resulting in simplified effective dynamics and control, and a high degree of passive stabilization with dynamic maneuvers. A hybrid pneumatic-electric actuator was built and tested while driving a knee joint; this actuator is capable of precise positioning, as well as highly energetic thrusting. It will be shown that static and dynamic maneuvers are attainable with a tendon-coupled ankle, and that a tendon allows simpler dynamic control through the concept of impulse compensation, and through the use of passive stabilization from the kinematics resulting from the tendon. Second, it will be shown that the hybrid actuator is superior in some respects to current available technology, both by specification, and by experimental results of static and dynamic maneuvers achieved through its use. And third, using a general heuristic-based control algorithm developed for various sized bipedal machines, dynamic maneuvers are possible with a high leg-to-body moment of inertia ratio, which would show that the control strategy takes into account the dynamics of the legs during high speed locomotion.
  • 2010
    Galliher, Wesley Charles; Cegelski, Lynette; Trost, Barry M.; Wender, Paul A.
    Biological barriers prevent the uptake of many potentially harmful xenobiotics yet also limit the delivery and cellular entry of a variety of drugs to their targets. One approach to this problem selects only those compounds with appropriate properties, namely solubility in polar biological fluids yet also able to pass through the nonpolar cellular membrane. This restriction would therefore preclude the use of many polar (e.g. siRNA) and nonpolar (e.g. Taxol) compounds whose inherent physical properties cause problems with formulation, distribution or bioavailability. The research described herein utilizes an alternative strategy that involves molecular transporters, which are agents that, when attached to poorly soluble or poorly bioavailable drugs, produce conjugates that exhibit excellent water solubility and simultaneously an increased ability to cross tissue and cell barriers. Bioactivatable molecular transporter conjugates of the immunosuppressant drug Cyclosporin A incorporating disulfide linkers were developed, evaluated for their biological activity in vitro, and administered topically in an in vivo mouse model. In addition to the inherent physical properties limitation that prevents drug passage across the cell membrane, another significant contributor to the failure of many therapeutics is the overexpression of membrane proteins (e.g. P-glycoprotein or Pgp) that mediate the unidirectional efflux of drugs out of target cells, often doing so prior to the drug reaching its intracellular target. Bioactivatable oligoarginine transporter conjugates of Taxol, a substrate for Pgp, were prepared and shown to overcome efflux-mediated resistance in primary human ovarian cancer tissue ex vivo. The encapsulation of transporter conjugates inside biodegradable polymeric nanoparticles was also investigated as a way to achieve sustained release of transporter drug conjugates over extended periods of time, thereby avoiding metabolism or toxicity problems associated with a bolus administration of therapeutic agents. Nanoparticles encapsulating transporter-probe conjugates were formed using two different methods, and shown to release their encapsulated cargo over time under biologically relevant conditions.
  • 2010
    DeChristopher, Brian Addison; Du Bois, Justin; Huestis, Wray H.; Wender, Paul A.
    The protein kinase C isozyme family has been implicated in a number of diseases representing the majority of the most significant challenges to global human health, including cancer, neurodegenerative diseases (Alzheimer's disease, depression, schizophrenia, etc.), cardiovascular disease, HIV/AIDS, diabetes, and chronic pain. As such, potent and selective modulation of this enzyme family using small molecule ligands designed for a particular function has tremendous therapeutic potential. A number of agents have been identified as ligands for the C1 domain of protein kinase C. Many of these compounds, including the endogenous ligand diacylglycerol and the complex bryostatin family of natural products, act by inducing an initial activation event, resulting in the translocation of protein kinase C to the plasma membrane where it can participate in the phosphorylation of downstream serine and threonine residues. The bryostatins are complex macrolides isolated from the marine organism Bugula neritina. Although a number of agents from this family of natural products have been shown to be biologically active, bryostatin 1 in particular has garnered tremendous therapeutic interest owing to its remarkable potency and activity profile. Specifically, bryostatin 1 has been shown to stimulate apoptosis, bolster the immune system, reverse multidrug resistance, synergize with other anticancer agents, enhance memory and learning in rodent models through the induction of synapse formation (synaptogenesis), reverse the effects of stroke in animal models, and induce latent HIV in vitro. As a result of this activity profile, bryostatin 1 is currently in phase I and II clinical trials for cancer treatment and is being advanced to the clinic for the treatment of Alzheimer's disease. However, despite its remarkable clinical potency (often ~ 1 mg is required for a 8 week treatment cycle in humans), the extremely low supply of bryostatin 1 prohibits its continued human clinical use and investigation for the treatment of additional therapeutic indications. In an effort to address the issues associated with the supply and unoptimized nature of a number of complex natural product protein kinase C ligands, the Wender group developed a pharmacophore model for C1 domain binding in the mid 1980s. This resulted in the design and synthesis of highly simplified, functional protein kinase C ligands based on the diacylglycerol scaffold. Additionally, structurally simplified, synthetically accessible bryostatin analogs were designed and shown to have comparable or even superior potency relative to bryostatin 1 for protein kinase C binding and in vitro anticancer activity. Described herein is the design, synthesis, and biological evaluation of a series of macrocyclic diacylglycerol analogs in an effort to improve protein kinase C affinity by reducing the entropic penalty of the binding event relative to the endogenous linear diacylglycerols. The binding affinity was found to be highly dependent on macrocycle size, with the most potent analog being up to two orders of magnitude more potent than the linear diacylglycerols (consistent with previous reports). Moreover, these analogs were prepared in a step-economical fashion (3-4 steps from commercial materials). Additionally, the design and synthesis of members of the first series of B-ring tetrahydropyran bryostatin analogs produced in the Wender group is reported. The use of a novel, high yielding Prins macrocyclization allowed for the retention of the synthetic convergency that has become a hallmark of the B-ring dioxane analogs produced previously in the Wender group. Several compounds from this B- ring tetrahydropyran class were found to be among the most potent analogs produced to date (with respect to protein kinase C affinity and in vitro anticancer activity). Despite the high potency and synthetic accessibility of the previously reported bryostatin analogs, these compounds lacked the ability to activate protein kinase C isozymes (as measured by their ability to induce the translocation of the enzyme from the cytosol to the plasma membrane) with a high degree of selectivity but were not equally non-selective either. The ability to tune isozyme selectivity has tremendous therapeutic potential and, in an effort to address this challenge, a series of A-ring functionalized, B-ring tetrahydropyran analogs was designed and synthesized using the Prins macrocyclization methodology. It was found that the C8 geminal dimethyl group on the A-ring in combination with C7 hydroxyl functionality imparts selectivity for the conventional protein kinase C [Beta]I over the novel protein kinase C [lowercase Delta}. Alternatively, C8 geminal dimethyl functionality in combination with C7 acetate functionality results in a high degree of non-selectivity for these isoforms. C13 functionalization was found to increase the potency of this already highly active analog class. Finally, several of the B-ring tetrahydropyran bryostatin analogs were shown to synergize with taxol in a human leukemia cell line. Additionally, a lead B-ring dioxane bryostatin analog was shown to be capable of inhibiting tumor growth in vivo in a transgenic mouse lymphoma model. Protein kinase C was implicated in this activity by monitoring the phosphorylation of downstream proteins as well as by performing inhibitor studies. This lead analog was also shown to induce apoptosis in a number of human B- and T-lymphocytes. The apoptotic induction observed in the murine cell line used for this pilot in vivo study was found to be independent of direct cell cycle effects. Significantly, this represents the first academic report of bryostatin analog efficacy and safety in vivo.
  • 2011
    Cooley, Christina B.; Du Bois, Justin; Kool, Eric T.; Wender, Paul A.
    My graduate studies have focused on the design, synthesis, and biological evaluation of novel probe and drug delivery technologies. This research has explored the development of new molecular transporter scaffolds with a focus on step economy and translational costs as well as evaluation of their uptake and delivery properties in cells and animals. Chapter 1 provides a historical context and overview of guanidinium-rich molecular transporter technology. Chapter 2 describes the development of a new family of guanidinium-rich oligocarbonate molecular transporter which are flexibly and efficiently assembled by a one-step oligomerization strategy. These novel oligocarbonate transporters were shown to exhibit excellent uptake properties both in cells and animal models. Chapter 3 is directed at the utility of an oligomerization approach to generate molecular transporters by the design, synthesis, and evaluation of new aphipathic co-oligomers for the delivery of siRNA, an oligonucleotide cargo of intense therapeutic interest. Amphipathic carbonate co-oligomers were prepared by an oligomerization strategy and demonstrated to effectively package, deliver, and release functional siRNA in cells. Chapter 4 describes the effects of a branched guanidinium array on the transport and delivery efficiency of releasable dendrimeric guanidinium-rich transporters. These transporters were synthesized and demonstrated to deliver and release a small molecule for turnover by its intracellular target enzyme by bioluminescence assays in cells and transgenic animal models. Chapter 5 describes the design, synthesis, and preliminary biological evaluation of lipidated molecular transporter derivatives of the immunosuppressant drug rapamycin for topical delivery.
  • 2013
    Stanzl, Erika Geihe; Kanan, Matthew William; Waymouth, Robert M.; Wender, Paul A.
    My graduate studies have focused on the development of novel drug delivery technologies of research, clinical, and industrial significance. More specifically, my research has focused on the design, synthesis, and application of guanidinium-rich molecular transporters for the delivery of siRNA into cells. My studies have also focused on using molecular transporters to develop the first molecular method to deliver cargo into algae, and on the development of new strategies to control the timing and amount of drug or probe release in cells. Though all of this research is fundamentally based on organic chemistry, these projects have broad applications in research, industrial and clinical settings. Chapter 1 reviews the strategies that have been developed for the delivery of siRNA in both cells and animals. Rather than divide the field by chemical type (e.g. peptide vs. protein) or disease indication, this review categorizes siRNA deliver agents by the identity of their cationic moiety for siRNA complexation. Guanidinium-containing delivery vectors are presented, as are vectors containing ammonium and phosphonium groups. Highlighting this field by cationic moiety reveals how little research has been done to compare the effects of the cation's identity on deliver efficacy, toxicity, and pharmacokinetics. Chapter 2 describes the design, synthesis, and evaluation of guanidinium-rich amphipathic oligocarbonate molecular transporters for the complexation, delivery, and release of siRNA in cells. The synthetic ease of the metal-free carbonate oligomerization to synthesize these transporters afforded fast access to a series of transporters that systematically probed the functionality required for effective complexation, delivery, and release of siRNA. Transporters were characterized and evaluated for biological activity in immortalized human keratinocytes. The transporters discovered in this study were highly effective, with target gene silencing of up to 90% observed. Chapter 3 focuses on efforts towards expanding the scope of both the chemical space and cell types tested in the delivery of siRNA with amphipathic oligocarbonate molecular transporters. These second generation delivery systems have improved physical properties, including smaller and more stable particle sizes, relative to their first generation counterparts described in Chapter 2. These transporters delivered siRNA to primary keratinocytes, melanoma cells, and ovarian cancer cells. Chapter 4 details the development of the first molecular method for the delivery of small molecule probes and large protein cargos into algal cells. It was shown that oligoarginine could facilitate the uptake of fluorescein, or the larger, FAM-streptavidin protein, into cells. A catalytically active protein was delivered into cells and was shown to maintain catalytic activity even after delivery. Chapter 5 describes the design of new strategies to control the timing and amount of cargo released inside cells. Efforts towards a novel linker carrying two copies of drug or probe are described, as well as the combination of microneedles and luciferin-transporter conjugates for transdermal delivery in vivo.
  • 2011
    Cardin, Nathan B.; Du Bois, Justin; Kanan, Matthew William; Wender, Paul A.
    In this work, a function-oriented array of simplified analogs of the daphnane diterpene orthoester class of natural products bearing palmitate, phenyl, or phenylacetyl orthoesters was synthesized starting from commerically available starting materials via a key late stage common diversification intermediate. These families of novel compounds were evaluated for both selective PKC activation and growth inhibition of K562 (myleogenous leukemia) cancer cells. While these analogs showed no growth inhibitory activity in K562 cells up to concentrations of 10 micromolar, they did display varying profiles of PKC activation. One analog in particular demonstrated the ability to activate and cause translocation of conventional PKC b1 and novel PKC d to the same extent as resiniferonol, a potent natural resiniferonoid. A second analog, however, was found to activate novel PKC d selectively over conventional PKC b1; surprisingly, resiniferonol did not share this selectivity profile. Because the simplified, functional analogs synthesized in this study were shown to activate PKC while having no growth inhibitory activity, these compounds should be further investigated for their potential as therapeutic leads for the treatment of diseases like Alzheimer's or Parkinson's, in which (selective) activation of PKC could serve a therapeutic purpose without being plagued by growth inhibitory pathways.
  • 2015 Springer Protocols
    Thiel, Gerald.
    Defining the functional equivalence of wild-type and chemically engineered G protein-coupled receptors / Elisa Alvarez-Curto and Graeme Milligan -- Design and analysis of an arrestin-biased DREADD / Ken-ichiro Nakajima ... [et al.] -- Regulation of gene transcription following stimulation of Gαq-coupled designer receptors / Oliver G. Rössler and Gerald Thiel -- Chemogenetic deconstruction of feeding circuits / Michael Krashes -- Dissecting neuronal circuits involved in olfactory-mediated behaviors / Alexia Nunez-Parra ... [et al ] -- Use of DREADDs (Designer Receptors Exclusively Activated by Designer Receptors) in transgenic mouse behavioral models / Daniela Cassataro and Lucas Sjulson -- Pharmacogenetic dissection of neural mechanisms underlying the regulation of sleep-wakefulness using DREADDs / Michihiro Mieda and Takeshi Sakurai -- DREADD'ed addiction : using designer receptors to delineate neural circuits underlying drug-seeking behaviors / Sunila G. Nair, Denis Smirnov, and John F. Neumaier -- DREADDs in Drosophila melanogaster / Charles D. Nichols and Jaime Becnel.
  • 2006 Springer
    Clarkson, John; Langdon, Patrick; Robinson, Peter.
  • 2011
    Creswell, John W.; Plano Clark, Vicki L.
    PrintStatus: Not Checked OutLane Catalog Record
    "Combining the latest thinking about mixed methods research designs with practical, step-by-step guidance, the Second Edition of Designing and Conducting Mixed Methods Research now covers six major mixed methods designs. Authors John W. Creswell and Vicki L. Plano Clark walk readers through the entire research process, from formulating questions to designing, collecting data, and interpreting results and include updated examples from published mixed methods studies drawn from the social, behavioral, health, and education disciplines."--pub. desc.
  • 2013
    Marshall, Lewis A.; Fuller, Gerald G.; Goodson, Kenneth E.; Santiago, Juan G.; Shaqfeh, Eric S. G.
    Purified DNA serves as a template for a wide array of analysis techniques, ranging from sequencing to PCR and hybridization assays. DNA analysis can be used for clinical diagnosis, for forensic investigation, and for a range of research purposes. These analysis techniques improve each year, but they are all constrained by the availability of purified DNA. DNA is typically derived from raw biological samples that contain a host of other molecular species, including proteins, lipids and metal ions. These species can inhibit analysis of the DNA, so purification of DNA from complex sample matrices is a necessary precursor to analysis. Typically, DNA purification is performed using either liquid-liquid extraction or solid-phase extraction, both of which require manual labor, involve toxic chemicals, and are difficult to miniaturize. Isotachophoresis (ITP) is an alternative method for DNA purification that does not rely on specialized surface chemistry or toxic chemical species. Instead, ITP uses electric fields to selectively pre-concentrate DNA from a raw sample, and simultaneously separate it from inhibiting species. ITP purification of DNA has been demonstrated from human serum, plasma, and whole blood, and the same technique has been used to purify RNA from bacteria in human blood and urine. Until recently, the parameters governing extraction efficiency, throughput, and separation quality in ITP purification were not well established. This thesis is focused on rational analysis for designing and optimizing ITP systems for rapid, high quality DNA purification.
  • 2007 Ovid
    Hulley, Stephen B.
    Designing a randomized blinded trial / Steven R. Cummings, Deborah Grady, and Stephen B. Hulley -- Alternative trial designs and implementation issues / Deborah Grady, Steven R. Cummings, and Stephen B. Hulley -- Designing studies of medical tests / Thomas B. Newman ... [et al.] -- Utilizing existing databases / Deborah Grady and Norman Hearst -- Addressing ethical issues / Bernard Lo -- Designing questionnaires and interviews / Steven R. Cummings and Stephen B. Hulley -- Data management / Michael A. Kohn -- Implementing the study and quality control / Deborah Grady and Stephen B. Hulley -- Community and international studies / Norman Hearst and Thomas E. Novotny -- Writing and funding a research proposal / Steven R. Cummings and Stephen B. Hulley. Getting started: the anatomy and physiology of clinical research / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Conceiving the research question / Steven R. Cummings, Warren S. Browner, and Stephen B. Hulley -- Choosing the study subjects: specification, sampling, and recruitment / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Planning the measurements: precision and accuracy / Stephen B. Hulley, Jeffrey N. Martin and Steven R. Cummings -- Getting ready to estimate sample size: hypotheses and underlying principles / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Estimating sample size and power: applications and examples / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Designing a cohort study / Steven R. Cummings, Thomas B. Newman, and Stephen B. Hulley -- Designing cross-sectional and case-control studies / Thomas B. Newman ... [et al.] -- Enhancing causal inference in observational studies / Thomas B. Newman, Warren S. Browner, and Stephen B. Hulley --
    Also available: Print – 2007
  • 2013 Ovid
    Browner, Warren S.; Cummings, Steven R.; Grady, Deborah; Hulley, Stephen B.; Newman, Thomas B.
    "This book provides a practical guide to planning, tabulating, formulating, and implementing clinical research, in an easy-to-use, readable presentation"--Provided by publisher.
    Also available: Print – 2013
  • 2008 Springer
    Clarkson, John; Langdon, Patrick; Robinson, Peter.
  • 2013 ScienceDirect
    Carter, Matt.
    "Clear, polished, and stimulating presentations are as important to the scientific profession as they are to business, yet most scientists never receive formal training in the creation, delivery, and evaluation of such material." ... "Designing Science Presentations provides visually intensive guidance at every step-from the construction of original figures to the presentation and delivery of those figures in papers, slideshows, posters, and websites." --Excerpts from publisher's description.
  • 2002 ScienceDirect
    Greer, Robert Douglas.
  • 2012 CRCnetBASE
    Charness, Neil; Demiris, George; Krupinski, Elizabeth A.
    "As simple and straightforward as two health professionals conferring over the telephone or as complex and sophisticated as robotic surgery between facilities at different ends of the globe, telehealth is an increasingly frequent component in healthcare. A primer on the human factors issues that can influence how older adults interact with telehealth systems, Designing Telehealth for an Aging Population: A Human Factors Perspective examines the new ways patients and healthcare providers communicate to achieve the same or better outcomes than with traditional face-to-face healthcare.The authors examine older adult capabilities and provide standards and guidelines for telehealth design, enlivened by clinical examples and tutorials on human factors methodologies. They take a systematic look at how the use of human factors principles can facilitate the successful development, deployment, and maintenance of telehealth technology to better serve the aging population. The authors have carefully stayed away from academic writing, distilling their experience in the form of basic observations and principles drawn from their work. They include suggested readings at the end of each chapter that supply the research underpinning their recommendations. The first reference to cover older adult users in an area that will only get bigger, this book sets itself apart by providing focused coverage of the human factors issues specific to aging populations and practical advice on how to accommodate them"-- Provided by publisher.
  • 2005 CRCnetBASE
    Wiklund, Michael E.; Wilcox, Stephen B.
  • 2011 Springer
    Leroy, Gondy.
    Part I Designing the User Study -- Overview -- Variables -- Design equation and statistics -- Between-subjects design -- Within-subject designs -- Advanced designs -- Part II Practical Tips -- Understanding main and interaction effects -- Conducting multiple comparisons -- Gold standard and user evaluations -- Recruiting and motivating study participants -- Institutional review board (IRB) approval -- Resources -- Part III Common Mistakes to Avoid -- Avoid bias -- Avoid missing the effect -- Avoid missing variables or conditions -- Other errors to avoid -- Appendix: cookbook for designing user studies in informatics.
  • 2002 ScienceDirect
    Brinck, Tom; Gergle, Darren; Wood, Scott D.
  • 2012 Springer
    Harrington, David P.
  • 2008 CRCnetBASE
    Shinton, N. K.
    Also available: Print – 2008
  • 2008 CRCnetBASE
    Ebadi, Manuchair S.; Ebadi, Manuchair S.
    The pharmacokinetic basis of therapeutics -- The pharmacodynamic basis of therapeutics -- Adverse reactions and drug-drug interactions -- Herb-drug interactions -- Food-drug interactions.
  • 2011 Springer
    Litchman, Charisse.
    Clinical Presentation of Desmoid Tumors -- Pathology of Desmoid Tumors -- APC/β-Catenin Deregulation in Desmoid Tumors: Important Implications for Diagnosis, Prognosis, and Therapy -- Imaging Techniques in Desmoid Tumors -- Surgical Management of Desmoid Tumors -- Systemic Therapy in the Treatment of Desmoid Tumors -- Radiation Therapy for Desmoid Tumors -- Interventional Radiology -- Introduction -- Desmoid Disease in Familial Adenomatous Polyposis -- Desmoid Tumor in Children and Adolescents: The Influence of Age -- Microarrays and High-Throughput Sequencing in Desmoid-Type Fibromatosis and Scar -- Desmoid Tumors: Are They Benign or Malignant? -- The Role of Patient Advocacy Groups in Rare Tumors Such as Desmoid Tumors.
  • 2013
    Arnold, K.; Arnold, Muoi M.; Jianfang, Zhang.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 CRCnetBASE
    Hefle, Sue L.; Koppelman, Stef J.
  • 2010
    Supekar, Kaustubh Satyendra; Greicius, Michael D.; Menon, Vinod; Musen, Mark A.; Rubin, Daniel.
    Understanding human brain function is one of the most important endeavors in modern science. There is growing evidence that cognitive functions are executed by large-scale networks, comprising multiple interacting anatomically-connected brain areas. Although considerable progress has been made in understanding which specific brain areas are involved in particular cognitive functions, very little is known about the integrative functioning of large-scale brain networks. This is due in part to the lack of methods to pursue this line of research. This dissertation describes computational methods for detecting and characterizing large-scale human brain networks, combining data from task-free functional magnetic resonance imaging (fMRI) and structural diffusion tensor imaging (DTI), two complementary brain imaging modalities. Application of our methods to task-free fMRI and DTI data obtained from a wide range of subject populations provided new insights into how large-scale human brain networks develop, mature, and get disrupted in psychiatric and neurological disorders. More generally, this work demonstrates the power of our multimodal network-analytic approach to obtain a system-level understanding of brain function across the human lifespan.
  • 2010
    Aksoy, Murat; Bammer, R.; Moseley, Michael E.; Pauly, John M.
    Due to the sequential nature of magnetic resonance imaging (MRI) data acquisition, correction of image artifacts originating from involuntary patient motion is essential for reliable diagnostic quality. Especially during MRI scans of certain patient populations such as children, elderly or patients with certain medical conditions (e.g. stroke, Parkinson's), motion correction methods must be incorporated into the MR imaging protocol for adequate image quality. With increased demands for higher resolution or time-resolved examinations (e.g. functional MRI), examination times also increase and even willing patients might have trouble staying still during the course of the examination. The first part of this thesis provides a method for retrospective correction of head motion artifacts using a multi-shot spiral-in \& out readout and parallel-imaging based iterative image reconstruction. The spiral-in part provided a low resolution image that was used for measurement of head motion. Due to rotational motion, locally undersampled areas appear in MR acquisition space (i.e., k-space), which violate the Nyquist theorem and cause artifacts even after motion correction. These artifacts were addressed through the data redundancy provided by multiple receiver channels that is present in modern receiver coils and an iterative conjugate-gradient based reconstruction. This method was then applied to diffusion tensor imaging (DTI) with multi-shot readout. Since DTI uses directional gradients to encode diffusion, rotational motion causes the image contrast to change, and it becomes incorrect to combine data with varying diffusion encodings on them. To address this issue, a non-linear conjugate gradient based reconstruction is presented and it is shown that this method provided more accurate description of white matter pathways compared to traditional methods. In the second part of this thesis, a prospective motion correction system using an optical tracking device is presented. Such systems are preferable compared to retrospective navigator-based methods due to various reasons, such as ability to perform motion correction independent of the MR data acquisition and immunity to spin history effects. The system proposed used a single camera mounted on the head coil and a self-encoded checkerboard marker mounted on the patient's forehead. Results on structural and diffusion imaging revealed that prospective motion correction outperforms retrospective navigator-based schemes. In the last part of the thesis, entropy-based retrospective autofocusing was used in combination with motion data obtained from prospective tracking to remove residual motion artifacts in the images. This method was especially useful for removing errors caused by inaccurate cross-calibration between the scanner and camera frame-of-references. It was also shown that prospective tracking can be the enabling technology for autofocusing in 3D acquisitions.
  • 2009
    Bethune, Michael Thomas.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010
    Bates, Steven R.; Covert, Markus; Ferrell, James Ellsworth; Quake, Stephen R.
    In the era of rapid high-throughput DNA sequencing and increasing bioinformatic capabilities to analyze large amounts of biological data, it is especially important to continue to develop high-throughput experimental proteomic methods. Probing physical interactions among proteins and nucleic acids is a powerful approach to gain insight into their functional relationships. Microfluidic tools are of great potential value to this field because they make it possible to run hundreds or thousands of independent experiments in parallel and at a high spatial density. Here I present and explain MITOMI (mechanically induced trapping of molecular interactions), an in vitro method that was initially created to measure the affinities of transcription factors binding to DNA. I contributed to the development of the system so it could be applied to mapping protein-protein interaction networks, and used it to study the interactions of E. coli RNA polymerase in order to better understand the regulation of bacterial transcription. I also extended the utility of MITOMI by adapting it to be able to measure interaction kinetics and to more efficiently measure affinities. With the ability to discover interactions at a large scale and to quantitatively characterize them on the same platform, MITOMI constitutes a valuable contribution to proteomic methodology.
  • 2009 Karger
    Pitts, Nigel.
    Introduction : how the detection, assessment, diagnosis and monitoring of caries integrate with personalized caries management / Pitts, N.B. -- Clinical visual caries detection / Topping, G.V.A., Pitts, N.B. -- Traditional lesion detection aids / Neuhaus, K.W. ... [et al.] -- Novel lesion detection aids / Neuhaus, K.W. ... [et al.] -- Lesion activity assessment / Ekstrand, K.R. ... [et al.] -- Patient caries risk assessment / Twetman, S., Fontana, M. -- Dentition and lesion history / Eggertsson, H., Ferreira-Zandona, A. -- Assessing patients' health behaviours : essential steps for motivating patients to adopt and maintain behaviours conducive to oral health / Freeman, R., Ismail, A. -- Personalized treatment planning / Pitts, N.B., Richards, D. -- Background level care / Pitts, N.B. -- Traditional preventive treatment options / Longbottom, C., Ekstrand, K.R., Zero, D.T. -- Novel preventive treatment options / Longbottom, C. ... [et al.] -- Traditional operative treatment options / Ricketts, D.N.J., Pitts, N.B. -- Novel operative treatment options / Ricketts, D.N.J., Pitts, N.B. -- Recall, reassessment and monitoring / Clarkson, J.E. ... [et al.] -- Implementation : improving caries detection, assessment, diagnosis and monitoring / Pitts, N.B -- Glossary of key terms / Longbottom, C. ... [et al.].
  • 2010 Springer
    Magni, Mariapia Viola.
    Part 1. BIOTERRORISM PREVENTION -- Bioterrorism: A Potential Weapon for Terrorist Attacks Through Food and Water Contamination: Evolution of Our Understanding of the Use of Chemical and Bacteriological Weapons / Vincenzo Costigliola and Franco Quagliata -- Detection and Quantification of Bacteria and Fungi Using Solid-Phase Cytometry / Lies ME Vanhee, Eva D'Haese, Ils Cools, Hans J Nelis and Tom Coenye -- Vulnerability Assessment and Mapping of Akounq Groundwater Body, Armenia / Vahram Vardanyan and Artashes Aginian -- Part 2. BACTERIA DIAGNOSTIC TESTS -- Methods for Detection of Shiga-Toxin Producing Escherichia coli (STEC) / Jordan Madic -- Genetic Diversity of Enterococci in Bryndza Cheese / Roman Dušinský, Anna Belicová, Libor Ebringer, Dušan Jurkovič and Lívia Križková, et al. -- Salmonella Infections / Constantine Arvanitakis -- Molecular Diagnostics of Staphylococcus aureus / Jiří Doškař, Roman Pantůček, Vladislava Růžičková and Ivo Sedláček -- Molecular Methods to Detect Bacillus cereus and Bacillus thuringiensis in Foods / Marisa Manzano, Lucilla Iacumin, Cristina Giusto and Giuseppe Comi -- Control of Listeria monocytogenes in San Daniele Dry Cured Ham by Different Technologies: Reduction of L. Monocytogenes in Dry Cured Ham / Lucilla Iacumin, Marisa Manzano, Milena Osualdini, Carlo Cantoni and Giuseppe Comi -- Part 3. VIRAL INFECTIONS -- Epidemiology and Diagnosis of Hepatitis B in the Mediterranean Region and Elsewhere / Nurdan Tözün, Özdal Ersoy, Fatih Eren and Veysel Tahan -- Hepatitis E Virus (HEV) - An Emerging Viral Pathogen / Avrelija Cencič and Walter Chingwaru -- Dengue Virus Diagnostics / Evgeni Eltzov, Danit Atias, Levi Gheber and Robert S. Marks -- Part 4. PARASITES AND FUNGI -- Infectious Forms of Parasites in Food: Man Embedded in Ecosystems / Eduardo Dei-Cas, Cécile-Marie Aliouat, Gabriela Certad, Colette Creusy and Karine Guyot -- Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis / Magdalena Dąbrowska, Barbara Gołos, Elżbieta Wałajtys-Rode, Patrycja Wińska and Joanna Cieśla, et al. -- Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases? / Fabrizio Bruschi, Lorena Chiumiento and Gianfranco Del Prete -- Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum / C Creusy, G Certad, K Guyot and E Dei-Cas -- Smart Biosensors for Determination of Mycotoxines / Lyubov Yotova, Ivo Grabchev, Rossica Betcheva and Dessislava Marinkova.
  • 2015 Springer Protocols
    Kurien, Biji T.; Scofield, R. Hal.
    Western blotting : origin and ascent of the species / W. Neal Burnette -- Methods to concentrate proteins for protein isolation, proteomic, and peptidomic evaluation / J. P. Dean Goldring -- Measuring protein concentration on nitrocellulose and after the electrophoretic transfer of protein to nitrocellulose / J. P. Dean Goldring -- Detection of blotted proteins : not all blockers are created equal / Vishal Kothari and Suresh T. Mathews -- Protein stains to detect antigen on membranes / Anil Dsouza and R. Hal Scofield -- Fluorescent labeling of proteins and its application to SDS-PAGE and Western blotting / F. Javier Alba, Salvador Bartolomé, Antonio Bermúdez, and Joan-Ramon Daban -- Rapid, antibody-free detection of recombinant proteins on blots using enzyme fragment complementation / Neil W. Charter, Joe Horecka Chin-Yee Loh, Albert Doan, Tom Wehrman, and Keith R. Olson -- Use of nonradioactive detection method for north and South-Western blot / Claudia Franke, Daniel Gräfe, Holger Bartsch, and Michael P. Bachmann -- Immunoblotting using radiolabeled reagents for detection / Holger Bartsch, Claudia Franke, and Michael P. Bachmann -- Immunoblotting of antigens : whole, strip, and new-line nitrocellulose membrane immunoblotting using the chemiluminescence technique / Yaser Dorri -- Detection of protein carbonyls by means of biotin hydrazide-streptavidin affinity methods / Kenneth Hensley -- Direct immunodetection of antigens within the precast polyacrylamide gel / Surbhi Desai, Boguslawa R. Dworecki, and Marie C. Nlend -- Quantitative analysis of signal transduction with in-cell Western immunofluorescence assays / Vince Boveia and Amy Schutz-Geschwender -- Ultrasensitive protein detection on dot blots and Western blots with semiconducting polymer dots / Fangmao Ye, Polina B. Smith, and Daniel T. Chiu -- Co-detection of target and total protein by CyDye labeling and fluorescent ECL plex immunoblotting in a standard proteomics workflow / Caitriona Scaife, Ciara A. McManus, Pamela M. Donoghue, and Michael J. Dunn -- Using biotinylated proteins to demonstrate immunodetection of antigens via Western blotting, dot blots, and immunohistochemistry / Thomas Millar, Ronald Knighton, and Jo-Anne Chuck -- Calcium binding by Ro 60 multiple antigenic peptides on PVDF membrane / Biji T. Kurien and Michael P. Bachmann -- Sequential use of immunoblots for characterization of autoantibody specificities / Holger Bartsch and Michael P. Bachmann -- Nanogold immunodetection detection systems for the identification of autoantigens by Western blotting / Jacen S. Moore and R. Hal Scofield -- Application of intermittent microwave irradiation to Western blot analysis / Yu-Ting Liu and Shinya Toyokuni -- Visualization of unstained protein bands on PVDF / Jun Park, Masaharu Mabuchi, and Ajay Sharma -- Multiplexed fluorescent immunodetection using low autofluorescence Immobilon®-FL membrane / Jun Park, Masaharu Mabuchi, and Ajay Sharma -- Cold microwave-enabled protein detection and quantification / Niels Grützner, Romy M. Heilmann, Aaron G. Smith, Carol B. Johnson, Stanislav Vitha, Jörg M. Steiner, and Andreas K. Holzenburg -- TLC-blot (Far-Eastern blot) and its application to functional lipidomics / Takao Taki -- Analysis of electroblotted proteins by mass spectrometry / Jose L. Luque-Garcia and Thomas A. Neubert -- On-membrane renaturation of recombinant Ro60 autoantigen by calcium ions / Biji T. Kurien and Michael P. Bachmann -- Phosphoprotein detection on protein electroblot using a phosphate-specific fluorophore / Lee Broderick Bockus and R. Hal Scofield -- Purification of tryptic digests on polyvinylidene difluoride membrane / Biji T. Kurien and R. Hal Scofield -- Detection of blotted proteins on nitrocellulose/PVDF membranes by Alta / Jayanta K. Pal, Shilpa J. Rao, and Dhanashri J. Godbole -- Nonstripping "rainbow" and multiple antigen detection (MAD) Western blotting / Stan (Stanislaw) Krajewski, Michelle M. Tsukamoto, Xianshu Huang, and Sebastian B. Krajewski -- Supported molecular matrix electrophoresis / Yu-ki Matsuno and Akihiko Kameyama -- Parafilm-M®, an available cost-effective alternative for immuno-blot pouches / Syed M. S. Quadri -- Succinylation-alcian blue staining of mucins on polyvinylidene difluoride membranes / Akihiko Kameyama, Weijie Dong, and Yu-ki Matsuno -- Comparison of chemiluminescence vs. infrared techniques for detection of fetuin-A in saliva / Suresh T. Mathews, Emily Graff, Robert L. Judd, and Vishal Kothari -- A novel methodology for stripping and reprobing of Western blots originally developed with colorimetric substrate TMB / Parmita Kar, Saurabh Kumar Agnihotri, Archana Sharma, Rekha Sachan, Madan Lal Bhatt, and Monika Sachdev -- Other notable methods of membrane protein detection : a brief review / Biji T. Kurien and R. Hal Scofield -- Nitrocellulose membrane : the new canvas / Jasmin R. Kurien and Bianca A. Kurien -- Invisible ink marking in ECL membrane assays / Biji T. Kurien.
  • 2005 CRCnetBASE
    Sun, Yin; Ong, Kwok Y.
  • 2009 Springer
    Loue, Sana; Sajatovic, Martha.
    Health and wellness / Susan Hatters Friedman, Joy Stankowski, and Martha Sajatovic -- City living and mental health in history / Sandro Galea, Emily Goldmann, and Andrea Maxwell -- Mental health, mental health courts, and minorities / Lara Nochomovitz and Franklin J. Hickman -- Migration and mental health / Sana Loue -- Media, minorities, and the stigma of mental illness / Sandra S. Swantek -- Minority mental health and wellness: a perspective from health care systems / Siran M. Koroukian -- Social support, mental health, minorities, and acculturative stress / Deborah Goebert -- Religion and mental health among minorities and immigrants in the U.S. / Anahí Viladrich and Ana F. Abraído-Lanza -- Cultural considerations regarding perspectives on mental illness and healing / Declan T. Barry and Mark Beitel -- Gender and minority mental health: the case of body image / Laura Simonelli and Leslie J. Heinberg -- Family determinants of minority mental health and wellness / Stevan Weine and Saif Siddiqui -- Family-focused psychoeducational programs for minorities with serious mental illness / Amy Weismann de Mamani ... [et al.] -- Socioeconomic status: risks and resilience / Lara M Stepleman, Dustin E. Wright, and Kathryn A. Bottonari -- Psychiatric genetics: an update / Prashant Gajwani -- Substance abuse in minority populations / W.A. Vega and A. G. Gil -- Neurocognitive testing of minorities in mental health settings / Amir Poreh and Alya Sultan -- Stress and resilience / AnnaMaria Aguirre McLaughlin, Lisa Stines Doane, Alice L. Costiuc and Norah C. Feeney -- Methodological challenges in research on the determinants of minority mental health and wellness / Peter Guarnaccia.
  • 2006
    Middleman, Elaine Jacqueline.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011
    Keenan, Kathryn E.; Beaupré, Gary Scott; Delp, Scott; Gold, Garry E.
    Human articular cartilage can degrade, losing functional quality and eventually exposing bone surfaces; when significantly advanced, this cartilage degradation can be diagnosed as osteoarthritis (OA). Currently, knee OA can be diagnosed only when the disease is advanced and the patient is suffering from pain. There is no cure for knee OA, nor are there prevent preventative therapies; current treatment strategies relieve the pain of OA or completely replace the knee joint. To evaluate potential therapies and treatments, we need a method that can identify and measure changes to cartilage prior to the onset of degradation. Magnetic resonance imaging (MRI) is a potentially powerful tool to non-invasively evaluate the progression of knee OA by mapping MR image parameters to molecular and material properties that are known to change with disease. The goal of this dissertation was to determine MR image parameters that can be used to evaluate the progression of OA. We examined the biphasic and viscoelastic models of cartilage to determine cartilage material properties from indentation creep tests. We compared initial elastic modulus and cartilage macromolecules to MRI parameters, specifically T2 and T1rho relaxation times and T1rho dispersion. We determined that a predictive model based on T1rho relaxation time maps, which accounts for T2 relaxation time and the effects of age, may estimate longitudinal trends in GAG content in the same person. In addition, a simple T1rho dispersion estimate has the potential for substantial clinical impact by measuring changes in cartilage initial elastic modulus and macromolecules non-invasively. This work is an important step toward developing clinical methods for evaluating cartilage functional condition, and in turn, to advance work towards preventing and treating knee OA.
  • 2008
    Dattalo, Patrick.
    PrintStatus: Not Checked OutLane Catalog Record
    Basic terms and concepts -- Statistical power analysis -- Confidence intervals: measures of precision -- Computer-intensive methods -- Additional considerations, recommendations, and conclusions -- Worked examples.
  • OHR
  • ScienceDirect
    Jakoby, William B.
    Also available: Print – 1981
  • Sachs, Michael; Bauer, Hartwig; Schmiedebach, Heinz-Peter; Schwoch, Rebecca; Steinau, Hans-Ulrich.
  • 2012
    Damberg, Cheryl L.
    Methodology for Eliciting High-Priority Clinical Decision Support Targets -- Oncology Results -- Orthopedics Results -- Pediatrics Results -- Percutaneous Coronary Intervention Panel Results -- Discussion and Recommendations - Appendix A: Oncology Panel Materials - Appendix B: Orthopedics Panel Materials - Appendix C: Pediatrics Panel Materials - Appendix D: Percutaneous Coronary Intervention Panelist Materials.
  • 2006 NAP
  • 2011
    Park, Min Young; Barron, Annelise E.; Chen, James K.; Cochran, Jennifer R.; Jardetzky, Theodore; Wandless, Thomas.
    Biotherapeutics have regained their reputation as drug candidates in the drug market due to their remarkable specificity; however, the broader clinical use of biotherapeutics is often challenged by poor pharmacological properties. Therefore, there is enormous interest in developing peptidomimetics as alternative therapeutic options. Inspired by the first successful example of peptide-based antivirals, Fuzeon®, similar strategies to develop antivirals have been applied to many other viruses that share class I fusion protein-mediated viral fusion. Using human Respiratory Syncytial Virus (hRSV) as a model system, the second chapter of this dissertation demonstrates our successful effort to develop a protein-based assay using a 5-Helix Bundle (5HB) fluorescence polarization (FP) as a screening platform for hRSV fusion inhibitors. The remaining chapters in this thesis all utilize the 5HB-based FP assay to evaluate the potential of short peptides and their peptoid-based peptidomimetics as antivirals to control hRSV infections. The third chapter proposes that NMEGylation, an alternative to PEGylation that uses a covalent attachment of an oligo-N-methoxyethylglycine (NMEG) chain, may enhance the bioavailability of short therapeutic peptides. The incorporation of optimized numbers of NMEG monomers along with a glycine linker increases the solubility and serum stability greatly, suggesting that NMEGylation may open a new opportunity to use peptoids as modifiers of therapeutically attractive peptides and proteins. The fourth chapter demonstrates how our novel approach combining alanine, proline, and sarcosine scans can be useful to determine peptoid-replaceable peptide residues and further proves the usefulness of the combined scan strategy using the C20 peptide as a parent peptide. Furthermore, two different methods to promote the [Alpha]-helical conformation of C20 analogues by structurally constraining the parent C20 peptide using "hydrocarbon-stapling" or "clicking" are described. We report a constrained C20 analogue with improved binding affinity, and discuss our structural investigations of the constrained C20 analogues using CD spectroscopy. The studies in the fifth chapter show that phage display can be used for identifying novel hRSV entry inhibitors that are not derived from the original sequence of the hRSV fusion protein F like the peptides described in chapters 2, 3, and 4. We report two 12-mer peptides with a low micromolar binding affinity to the 5HB, and ongoing efforts are aimed towards better understanding the interaction of the 12-mer peptides with the 5HB by co-crystallizing the peptides and 5HB. Finally, the dissertation concludes with a sixth chapter that summarizes the current status of each research chapter. In addition, future prospects, new directions, and potential applications of the findings in this dissertation are presented in this chapter.
  • 2011
    Burriesci, Matthew Strecker; Altman, Russ B.; Long, Sharon; Pringle, John R.; Sherlock, Gavin.
    This dissertation describes a general method for identifying and roughly quantifying the metabolites that are produced by symbiotic dinoflagellates and transferred to cnidarian hosts. I developed a system of rapid filtration and gas chromatography-mass spectrometry (GC-MS) to identify these compounds in the anemone tissue and dinoflagellates separately. I used 13C-sodium bicarbonate to label compounds produced from newly-fixed carbon; the principal compound detected in the animal was glucose. I developed a way to visualize these and other large GC-MS datasets using open-source software. I also built tools for analyzing Ultra-High-Throughput-Sequencing (UHTS) data, and these were useful in the de novo assembly of the Aiptasia pallida transcriptome. One tool I developed compares each read to each other read using a MapReduce framework to merge near-duplicate reads and reduce redundancy in the dataset. In addition, our lab sequenced symbiotic animals and therefore often worked with pools of sequences from multiple organisms. I developed a tool for identifying which transcript sequence was produced by which organism in a symbiotic ecosystem: it was 99% accurate on high-quality validation data.
  • 2010
    Sirota, Marina; Batzoglou, Serafim; Butte, Atul J.; Robinson, William H.
    Autoimmune diseases are painful and debilitating conditions which affect millions of people in the United States and all over the world. At present such conditions are often difficult to diagnose and many have no satisfactory treatment. Given the wealth and availability of genomic data such as genetic variation and gene expression, computational integrative methods provide a powerful opportunity to improve human health by refining the current knowledge about diagnostics, therapeutics and disease mechanism. For instance numerous genome-wide association studies (GWAS) performed across autoimmune diseases, provide a great opportunity to study disease relationships based on genetic variation. Comparing such profiles allows us to quantify allele-specific pair-wise relationships between these diseases to find two broad clusters of autoimmune disease. We furthermore find that certain polymorphisms, toggle SNPs, predispose individuals to one class of autoimmune disease but are protective against the other class. While studying allelic differences between diseases may point to key novel disease-specific genes and pathways, studying similarities across diseases might lead to discovery of common therapeutic options as well as common disease mechanisms. In particular we integrate genetic variation data across several studies to discover the role of a complement factor in Rheumatoid Arthritis and Multiple Sclerosis. Gene expression microarrays are also often used to study human diseases as well as the perturbation of biological systems by drug compounds providing an opportunity to discover novel relationships between diseases and drugs. We present a systematic computational method to predict novel therapeutic indications based on gene expression. We tested our top prediction for Crohn's disease (CD) using the rat model of inflammatory bowel disease (IBD), and successfully demonstrated the predicted efficacy of an anti-seizure drug in treating disease. In this work, we have showed that integrative computational tools can be used to improve diagnostics, learn more about disease mechanism and discover novel therapeutics for autoimmune disease.
  • 2013
    Phillips, Annie; Enderby, Pamela M.
    PrintStatus: Not Checked OutLane Catalog Record
    Want to communicate clearly, honestly and directly, without avoidance or resorting to manipulative or aggressive behaviour? Learn how to be assertive and explore its advantages as the primary tool of effective communication skills in healthcare settings. If you work in health or social care as a manager or clinician, deal with people on a daily basis, and need these dealings to be thoughtful, effective, and stress free, this is the book for you. It teaches you how to understand and alleviate barriers to effective communication, manage the stresses and conflicts, and develop the effective clinical, people and management skills you need to navigate successfully through a career in healthcare. It challenges the reader to re-construct their approach to communication and present themselves more confidently whilst encouraging investment in their personal and professional development. This highly practical guide, and its companion volume Developing Leadership Skills for Health and Social Care Professionals is a tool for all health and social care professionals wanting to develop relationships with their colleagues, patients and clients including clinicians, practice managers, nurses, midwives, general practitioners, therapists, doctors, dieticians, psychological therapists, paramedics and health visitors.
  • 2014
    Drain, Paul K.; Evert, Jessica; Hall, Thomas L.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008
    Moore, Keith L.; Persaud, T. V. N.; Torchia, Mark G.
    Introduction to the developing human -- The beginning of human development: first week -- Formation of bilaminar embryonic disc: second week -- Formation of germ layers and early tissue and organ differentiation: third week -- Organogenetic period: fourth to eighth weeks -- The fetal period: ninth week to birth -- the placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- The pharyngeal apparatus -- The respiratory system -- The digestive system -- The urogenital system -- The cardiovascular system -- The skeletal system -- The muscular system -- The limbs -- The nervous system -- The eye and ear -- The integumentary system -- Congenital anatomical anomalies or human birth defects -- Common signaling pathways used during development.
  • 2013
    Moore, Keith L.; Persaud, T. V. N.; Torchia, Mark G.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction to the developing human -- First week of human development -- Second week of human development -- Third week of human development -- Fourth to eighth weeks of human development -- Ninth week to birth: the fetal period -- Placenta and fetal membranes -- Body cavities and diaphragm -- Pharyngeal apparatus, face, and neck -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Skeletal system -- Muscular system -- Development of limbs -- Nervous system -- Development of eyes and ears -- Integumentary system -- Human birth defects -- Common signaling pathways used during development.
  • 2016 ClinicalKey
    Moore, Keith L.; Persaud, T. V. N.; Torchia, Mark G.
    Introduction to the developing human -- First week of human development -- Second week of human development -- Third week of human development -- Fourth to eighth weeks of human development -- Ninth week to birth : the fetal period -- Placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- Pharyngeal apparatus, face, and neck -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Skeletal system -- Muscular system -- Development of limbs -- Nervous system -- Development of eyes and ears -- Integumentary system -- Human birth defects -- Common signaling pathways used during development.
  • 2014 Springer
    Emans, Pieter J.; Peterson, Lars.
    This book reviews the current basic and clinical research into the mechanisms of cartilage injury and its management. It illustrates the considerable progress made in the search for solutions to cartilage related problems. Developing Insights in Cartilage Repair describes fundamental research and the use of biomaterials, bioreactors, and imaging as part of existing cartilage repair strategies, while revealing the on-going trends for emerging techniques. The aim of the Editors and their team of authorities in cartilage medicine has been to provide a link between laboratory work and the daily treatment of patients in a clinical setting. This book reveals the highly multidisciplinary nature of the topic and it will thus not only be of considerable interest to a large proportion of the orthopaedic community, but also any discipline in which cartilaginous tissue is involved, including otorhinolaryngology and plastic surgery.
  • 2005 HighWire
    Erdmann, Erland.
    Also available: Print – 2005
  • 2011
    Chung, Minsub; Boxer, Steven G.; Fuller, Gerald G.; Swartz, James R.
    Many cellular processes including cell-cell communications and regulated membrane transport are mediated by membrane proteins and depend upon the ability of lipid membranes to be a differentially permeable barrier. However, the roles and function of membrane proteins are often difficult to study due to the complexity of the native membranes and lack of reliable and flexible artificial model lipid membranes. Supported lipid bilayers (SLB) have been used as a model system to study biological membrane behavior and the structure and function of membrane proteins and receptors in a simpler context apart from the complex cellular environment. Although SLBs have the advantages of simple formation, easy handling and are well-suited for investigation by a suite of surface sensitive methods due to their planar geometry, the close proximity of the lower leaflet to the solid support often leads to unfavorable interactions with integral membrane proteins. This causes distortion of the protein conformation and possible loss of its reactivity and function. Moreover, this interaction with the substrate often traps proteins and reduces their mobility in the membranes. Recognizing this limitation, we have developed a new model membrane architecture in which the DNA-tethered lipid bilayer is either to fixed DNA on a surface or to laterally mobile DNA displayed on a supported bilayer. This separates the lipid membranes from surface interactions and provides a more favorable environment for integral membrane protein with large globular domains. With mobile DNA hybrid tethers, stable tethered bilayers were made with specific lipid composition, while those with fixed tethers are stable regardless of membrane composition. The mobile tethers between a tethered and a supported lipid bilayer offer a particularly interesting architecture for studying the dynamics of membrane-membrane interactions. By careful choice of composition, improved stability was obtained and we can investigate the lateral segregation of DNA hybrids when different lengths are present. Based on a theoretical model, the effects of population, length and affinity of DNA complexes are simulated and described. This model system captures some of the essential physics of synapse formation and is a step toward understanding lipid membrane behavior in a cell-to-cell junction. To demonstrate the excellent environment provided by DNA-tethered membranes for studying transmembrane proteins free from any surface interactions, the behavior of a transmembrane protein, the photosynthetic reaction center, reconstituted in the DNA-tethered membranes is investigated. Inspired by DNA-mediated membrane fusion studies of our group, we applied the DNA-machinery to achieve fusion of small (~ 100 nm) proteoliposomes for delivery of membrane proteins to either giant vesicles or DNA-tethered planar lipid membrane patches. The diffusion behavior of delivered proteins is measured and compared with those in supported bilayers. Also, the protein activity and orientation before and after fusion is analyzed. This will offer a feasible method to incorporate intact membrane proteins to already formed model membranes. In addition, the behavior of proteins during the fusion event will provide insight into the mechanism of DNA-mediated lipid membrane fusion. The geometry of our model membrane system directly mimics that of a neuronal synapse. We expect that this architecture will be readily transferable to other model membrane fusion systems, including systems using reconstituted SNARE proteins. Consequently, it will be of considerable interest to a wide range of researchers.
  • 2012
    Holmes, Tracy C.; Boxer, Steven G.; Dunn, Alexander Robert; Khosla, Chaitan.
    Developing novel therapies for gram-negative bacterial infections and glioblastoma multiforme I. cloning and characterization of the guadinomine biosynthetic gene cluster II. developing a novel chemo-sensitizing agent to treat glioblastoma. This thesis explores the development of novel therapies for the treatment of two complicated problems: Gram-negative bacterial infections and glioblastoma multiforme, the most aggressive form of brain cancer. Part I of the thesis summarizes the current body of knowledge regarding guadinomines, their biosynthesis and implications for developing novel anti-infective agents. Part II of the thesis summarizes the development of the small molecule, ERW1227B, and its ability to sensitize glioblastoma cells to standard therapies. Part I. Guadinomines are a recently discovered family of anti-infective compounds produced by Streptomyces sp. K01-0509. They are the first microbial metabolites shown to inhibit the Type III Secretion System (TTSS) of Gram-negative bacteria. The TTSS is required for the virulence of many pathogenic Gram-negative bacteria including Escherichia coli, Salmonella spp., Yersinia spp., Chlamydia spp., Vibrio spp., and Pseudomonas spp. Inhibition of the TTSS can mitigate virulence which is important considering that Gram-negative bacteria infect millions each year, leading to considerable morbidity and mortality. The guadinomine (gdn) biosynthetic gene cluster has been sequenced, and encodes a chimeric multimodular polyketide synthase -- nonribosomal peptide synthetase spanning 26 open reading frames and 51.2 kb. It also encodes enzymes responsible for the biosynthesis of the unusual aminomalonyl-ACP extender unit and the signature carbamoylated cyclic guanidine. Its identity was established by genetic inactivation of the cluster, as well as heterologous expression and analysis of enzymes in the biosynthetic pathway. Identifying the guadinomine gene cluster provides critical insight into the biosynthesis of these biologically important compounds. Part II. Glioblastomas display variable phenotypes that include increased drug-resistance associated with enhanced migratory and anti-apoptotic characteristics. These shared characteristics contribute to failure of clinical treatment regimens. Identification of novel compounds that both promote cell death and impair cellular motility is a logical strategy to develop more effective clinical protocols. Previously, we described the ability of the small molecule, KCC009, a tissue transglutaminase inhibitor, to sensitize glioblastoma cells to chemotherapy. In the current study, we synthesized a series of related compounds that show variable ability to promote cell death and impair motility in glioblastomas, irrespective of their ability to inhibit TG2. Each compound has a 3-bromo-4,5-dihydroisoxazole component that presumably reacts with a nucleophilic cysteine thiol residue in one (or more) target protein(s) that have affinity for the small molecule. Our studies focused on the effects of the compound, ERW1227B. Treatment of glioblastoma cells with ERW1227B was associated with both down-regulation of the PI-3 kinase/Akt pathway, which enhanced cell death; as well as disruption of focal adhesions and intracellular actin fibers, which impaired cellular mobility. Bioassays as well as time-lapse photography of glioblastoma cells treated with ERW1227B showed cell death and rapid loss of cellular motility. Mice studies with in vivo glioblastoma models demonstrated the ability of ERW1227B to sensitize tumor cells to cell death after treatment with either chemotherapy or radiation. The above findings identify ERW1227B as a potential novel therapeutic agent in the treatment of glioblastomas.
  • 2008
    Heimbach, James T.; Hibberd, Patricia L.; Hoffman, Freddie Ann.
  • 2009 ScienceDirect
    Chen, Yisheng; Qiu, Yihong; Zhang, Geoff G. Z.
  • 2013 Springer
    Melkikh, Alexey; Sutormina, Maria.
    Understanding the general laws of an effective system for the transport of substances in cells is an important goal of systems and synthetic biology and will help us to answer why the transport subsystem of a cell is arranged as it is. In addition, the construction of models for optimizing transport systems is of considerable importance in the early stages in the development of a functioning protocell. The aim of this book is to describe the latest techniques for the calculation of the optimal parameters of the transport subsystem of a cell at its maximum efficiency.
  • 2013
    Lehnert, Erik Michael; Fire, Andrew Z.; Frommer, Wolf B.; Pringle, John R.; Sherlock, Gavin.
    Coral reefs are animal-built structures that provide habitats for a disproportionately large number of marine species relative to the small percentage of the ocean that they cover. Corals, and some other cnidarians such as anemones, host dinoflagellates within the cells of their gastrodermal tissue. The dinoflagellates fix carbon photosynthetically and transfer it to the host; the dinoflagellates can provide up to 90% of the hosts' metabolic requirements. The symbiosis between the cnidarian host and its dinoflagellate symbiont is therefore the trophic foundation on which coral reef are built. Despite its importance, the molecular mechanisms controlling symbiosis establishment, maintenance, and breakdown remain poorly understood. Our lab is working to further develop the small sea anemone, Aiptasia, as a model system for studying cnidarian-dinoflagellate symbiosis. To this end, I sequenced the transcriptome of aposymbiotic Aiptasia, of symbiotic Aiptasia, and of the dinoflagellate symbionts. I then used these resources to perform gene-expression analysis comparing symbiotic and aposymbiotic anemones, which provided numerous testable biological hypotheses about both the structural basis of the symbiosis and the downstream metabolic effects of metabolite transfer to the host. These resources should serve as the foundation for future experiments in our laboratory and more widely in the field of coral biology.
  • 2011 CRCnetBASE
    Lundblad, Roger L.
    "A comprehensive assessment of biomarkers, this book covers the history and current status of the application of biomarkers in diagnostics and prognostics. It explores the technology used for the study of biomarkers, and the validation of biomarkers including a comparison of the various technologies used to identify and measure biomarkers. The editors emphasize the technology underlying biomarkers and the translation of basic science to clinical laboratory technology, including the commercial development of biomarkers. The book also covers proteomics and proteomic technologies and their applications in the identification of biomarkers"--Provided by publisher.
  • 2011
    Shestopalov, Ilya A.; Chen, James K.; Kool, Eric T.; Wender, Paul A.
    Embryonic development is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex multicellular organism. This process depends on spatial and temporal control of gene function, and deciphering the molecular mechanisms that underlie pattern formation requires novel methods for perturbing gene expression with similar precision. Synthetic reagents can help meet this demand, and in this thesis I describe the development and application of caged morpholino (cMO) oligonucleotides for inactivating genes in zebrafish and other optically transparent organisms with spatiotemporal control simply by irradiating embryonic tissues with a focused light beam. In chapter 1 I provide an overview of the zebrafish model system of vertebrate development and survey the capabilities and limitations of various oligonucleotide-based technologies for perturbing RNA function and tracking RNA expression in zebrafish. I examine various light-gated oligonucleotide technologies that exploit the optical transparency of zebrafish embryos, including cMOs, for achieving spatiotemporal control of RNA function. In chapter 2 we describe the initial synthesis of a cMO targeting expression of the no tail a (ntla) transcription factor. By permitting spatiotemporal gene regulation in zebrafish embryos, the ntla cMO was used to make initial observations into the time-dependent role of this gene in notochord formation. In chapter 3 we report optimized methods for the design and synthesis of hairpin cMOs, incorporating a dimethoxynitrobenzyl (DMNB)-based bifunctional linker that permits cMO assembly in only three steps from commercially available reagents. Using this simplified procedure, we have systematically prepared cMOs with differing structural configurations and investigated how the in vitro thermodynamic properties of these reagents correlate with their in vivo activities. Through these studies, I have established general principles for cMO design and successfully applied them to several developmental genes. Our optimized synthetic and design methodologies have also enabled us to prepare a next-generation cMO that contains a bromohydroxyquinoline (BHQ)-based linker for two-photon uncaging. Collectively, these advances established the generality of cMO technologies to facilitate the application of these chemical probes in vivo for functional genomic studies. Finally, in chapter 4 we illustrate the utility of the cMO technology in isolating spatiotemporally-distinct functions of transcription factors -- genes that play diverse roles during embryonic development, with each controlling multiple cellular states in a spatially and temporally defined manner. Resolving the dynamic transcriptional profiles that underlie these patterning processes is essential for understanding embryogenesis at the molecular level; however, probing in vivo gene function with comparable spatiotemporal precision has been a technological challenge. To address this need, I have integrated cMOs with similarly caged fluorophores, fluorescence-activated cell sorting (FACS), and microarray technologies. Using this approach, I have dynamically profiled the No tail-a (Ntla)-dependent transcriptome at different stages of zebrafish mesoderm development, discovering discrete sets of genes that are associated with either notochord cell fate commitment or subsequent changes in cell function. Our studies elucidated the roles of several Ntla-regulated genes in notochord development and demonstrated the activation of multiple transcriptomes within a cell lineage by a single transcription factor.
  • 2008
    Berger, Alicia Beth.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013
    Kaushal, Amit; Altman, Russ B.; Davis, Ronald W.; Xiao, Wenzhong.
    The ability to generate robust quantitative high-throughput protein abundance estimates directly from clinical samples would be useful for translational biomedical research. Knowing the protein content and abundance of a clinical sample would enable, for example, effective biomarker discovery, risk stratification of patient outcomes, and the ability to better understand disease mechanisms. Mass spectrometry has emerged as a powerful tool in the high-throughput measurement of proteins from human tissues and fluids. We are now beginning to have access to proteomics data of the coverage (hundreds to thousands of proteins), scale (tens to hundreds of samples), and throughput (a few days to weeks per experiment) to bring mass spectrometry proteomics to the study of clinical questions. In this work, we discuss methods for quantitation of peptide and protein abundance from mass spectrometry proteomics data. We apply our approaches to identify key proteins that are differentially expressed in the urine of kidney transplant patients with acute rejection. We also investigate the response of the human plasma proteome to severe burn injury. We characterize the protein composition of T-cells, monocytes, and neutrophils of trauma patients, healthy controls, and stimulated cells, and compare information content of proteomics data from these cell populations with gene expression data from similar samples. Finally, we discuss a novel metric for scoring normalization algorithms from mixture titration quality control experiments, and we apply this metric to proteomics and transcriptomics data. Through the methods for quantitation of peptides and proteins, application of proteomics to different clinical questions, and integration of proteomics with other high-throughput data, we demonstrate the utility of mass spectrometry based proteomics to the study of human biofluids in human disease research.
  • 2011 Springer
    Young, Gerald.
    1. Overview of the present work -- 2. The biopsychosocial and bio-personal-social models -- 3. Piaget and development -- 4. The present cognitive-affective stage model: I cognition -- 5. The present models: II postformal stage, neo-Eriksonian parallels, systems -- 6. Substages in the neo-piagetian models of Case, Fischer, and Young -- 7. Parallels in cognitive substages and socioaffectivity in Case -- 8. Parellels in cognitive substages and socioaffectivity in Fischer -- 9. Case and Fischer on language and the brain -- 10. Recent Case and colleagues -- 11. Further Fischer: comprehensive summary, adult development -- 12. Recent Fischer: emotional development -- 13. Self-development -- 14. Cognitive (mis)perception of the self and other -- 15. Social cognition/theory of mind -- 16. Self-definition and relatedness/self-regulation in development -- 17. Cognitive/socioaffective complexes and multiple intelligences -- 18. Postformal thought: commons' model -- 19. Development of personality and motivational needs -- 20. Socioemotional systems and neo-Eriksonian dangers -- 21. Approaches to emotions -- 22. Emotional development in infancy -- 23. Attachment basics -- 24. Internal working models and social self working schemata -- 25. Development of hemispheric specialization -- 26. Lateralization and developing cognition -- 27. Systems and development -- 28. Attractors, complexity -- 29. Causes and determinants of behavior -- 30. Gene-environment interactions: other topics --31. Stages and change in development and other systems -- 32. Collective intelligence and multilevel selection -- 33. Narrative discourse coding: cohesion in children's narratives -- 34. Narrative discourse coding: syntactic complexity-errors -- 35. Book conclusions.
  • 2009 Springer
    Burbach, Johannes Peter Henri; Pasterkamp, R. Jeroen; Smidt, Marten P.
    Development of the dopamine systems in zebrafish / Jørn Schweitzer and Wolfgang Driever -- Dopamine systems in the forebrain / John W. Cave and Harriet Baker -- The role of Otx genes in progenitor domains of ventral midbrain / Antonio Simeone ... [et al.] -- Terminal differentiation of mesodiencephalic dopaminergic neurons : the role of Nurr1 and Pitx3 / Marten P. Smidt and J. Peter H. Burbach -- Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons / Siew-Lan Ang -- Transcriptional regulation of their survival : the engrailed homeobox genes / Horst H. Simon and Kambiz N. Alavian -- Neurotrophic support of midbrain dopaminergic neurons / Oliver von Bohlen und Halbach and Klaus Unsicker -- TGF in dopamine neuron development, maintenance, and neuroprotection / Eleni Roussa, Oliver von Bohlen und Halbach, and Kerstin Krieglstein -- Axon guidance in the dopamine system / Asheeta A. Prasad and R. Jeroen Pasterkamp -- Protocols for generating ES-cell-derived dopamine neurons / Sonja Kriks and Lorenz Studer -- Molecular and cellular determinants for generating ES-cell-derived dopamine neurons for cell therapy / -- Jan Pruszak and Ole Isacson.
    Also available: Print – 2009
  • 2007
    Hahn, Angela T.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 Springer
    Erzurumlu, Reha S.; Guido, William; Molnár, Zoltán.
  • 2005 ScienceDirect
    Pelt, J. van.
    Section I. Neuronal network formation. Neuronal network formation in human cerebral cortex -- Section II. Molecular and cell biological mechanisms of neuronal network development and synapse formation. Regulation of dendritic growth by calcium and neurotrophin signaling. Dynamics and pathology of dendritic spines. Introduction to the sixteenth C.U. Ariens Kappers lecture. Mechanisms of retinotopic map developments: Ephs, ephrins, and spontaneous correlated retinal activity. Biologically plausible models of neurite outgrowth. Competition in neurite outgrowth and the development of nerve connections -- Section III. Synapse rearrangement. Molecular substrates of plasticity in the developing visual cortex. Excitatory-inhibitory balance and critical period plasticity in the developing visual cortex. Structural plasticity in the developing visual system. Mechanisms controlling the formation of retinal mosaics. Laminar circuit formation in the vertebrate retina -- Section IV. Structure and dynamics in neurons and neuronal networks. Dynamics and plasticity in developing neuronal networks in vitro. Learning in ex-vivo developing networks of cortical neurons. Role of synaptic inhibition in spatiotemporal patterning of cortical activity. Synaptic mechanisms that shape visual signaling at the inner retina. The involvement of glutamate-gated channels in negative feedback from horizontal cells to cones. Compensatory physiological responses to chronic blockade of amino acid receptors during early development in spontaneously active organotypic cerebral cortex explants cultured in vitro -- Section V. Dynamics in neural circuits in cognition. A visual salience map in the primate frontal eye field. Chronic multiunit recordings in behaving animals: advantages and limitations -- Section VI. Deficient circuitry and cognitive/behavioral pathology. Physiological studies of information processing in the normal and Parkinsonian basal ganglia: pallidal activity in Go/No-Go task and following MPTP treatment. Rho proteins, mental retardation and the neurobiological basis of intelligence. Neurodevelopment, neuroplasticity, and new genes for schizophrenia. The impact of seizures on developing hippocampal networks. Alzheimer's disease as a disorder of dynamic brain self-organization.
    Also available: Print – 2005
  • 2008
    Kotecha, Nikesh.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010
    Wang, Aaron Sheng-Chieh; Liang, David; Taylor, Charles A.; Zarins, Christopher K.
    Trauma patients require rapid diagnosis and treatment of hemorrhage. In the hospital, experienced sonographers can reliably diagnose vascular injury using duplex ultrasound. In trauma settings, such as the battlefield, a portable ultrasound device with an automated algorithm to detect bleeding would be useful for medics. Thus, an increasing interest in computer-aided bleed detection led to efforts in quantifying sonographic signatures of abnormalities at the site of vascular injury. However, since trauma patients often present with large areas of injury, there is a need to develop and evaluate bleed detection strategies for ultrasound that more efficiently assess a large vascular tree. The goal of this Ph.D. research dissertation is to address this need. The studies primarily focused on the upper extremity vasculature, specifically the brachial bifurcation, because the leading cause of preventable deaths due to vascular trauma has been exsanguinations from extremity injuries. The overall approach was to characterize normal blood flow with a well-established power law model and identify flows that deviate from the model. The power law states that blood flow is proportional to the vessel diameter raised to a power index k, where k is defined by the bifurcation geometry. A bleed detection metric, called the "flow split deviation" (FSD), was defined to quantify the flow deviations from the power law. Validation of this approach was undertaken in four steps. The first involved demonstrating that the power law model appropriately describes the normal brachial bifurcation and flows in man. The utility of the bleed metric was then evaluated with 3D computational models of bleeds. Finally, the proposed detection algorithm was applied on the early proof of concept humans in arteriovenous fistulas (AVF) of dialysis patients and in in vivo rabbit bleed models. A study with normal human subjects was used to determine that the best-fit k for the brachial bifurcation was 2.75, which is in agreement with other vasculatures previously studied. A k=2.75 power law was then shown to adequately predict forearm blood flows for both resting and exercise physiological states. The correlation coefficient R between predicted and measured normal flows was 0.98. Computational models suggested that FSD was a good indicator of the severity of bleed downstream from the bifurcation. In the patient case study, the bleed metric easily distinguished between normal arms and those with newly placed wrist AVFs, which caused on average an order of magnitude increase in flow deviations. Introduction of different femoral bleed rates in rabbits demonstrated good sensitivity and specificity of the bleed metric when applied to moderate lower extremity bleeds. Bifurcation FSDs can serve as a quantitative signature of bleeding and, moreover, as a strategic way to survey large vascular trees by following abnormal branch points to the likely source of hemorrhage. This approach can complement other quantitative sonographic methods to create a comprehensive, automated, ultrasound-based algorithm for vascular trauma detection.
  • 2006
    Wang, Alfred Y.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011
    Foo, Lynette Caizhen; Barres, Ben A.; McConnell, Susan K.; Shen, Kang; Talbot, William S.
    Astrocytes constitute more than half of the human brain, yet their functions have yet to be fully elucidated largely due to a lack of a good and pure in vitro culture system. The inability to purify and culture brain astrocytes has long hindered studies of their function. Although astrocyte progenitor cells can be cultured from neonatal brain, culture of more differentiated mature astrocytes from postnatal brain has not previously been possible. Here I report a new method for the prospective purification of astrocytes by immunopanning (IP-astrocytes) and have used this method to investigate several fundamental properties, functions of astrocytes and neuron-glial interactions. I show that these highly purified astrocytes, like neurons, undergo apoptosis in culture, but that vascular cells as well as exogenous HBEGF and Wnt7a strongly promote their survival in serum-free culture. Similarly, I found that developing astrocytes in vivo undergo apoptosis and that the vast majority of surviving astrocytes in vivo contact blood vessels and hypothesise that developing astrocytes may normally be matched to blood vessels by competing for a limited supply of vascular trophic factors. In contrast to the more traditional neonatal astrocyte cultures prepared via a method developed by McCarthy and de Vellis (1980) (MD-astrocytes), the gene profiles and functions of the purified postnatal astrocytes in serum-free culture much more closely resembled that of astrocytes in vivo. These astrocytes also strongly promoted synapse formation and function. I have also identified genes that are induced by serum and show that serum exposure to astrocytes causes massive and irreversible changes of gene expression as well as astrocyte function. In addition, I have highlighted several features of MD-astrocytes that are different from IP-astrocytes. Together, the data suggests that I have developed a culture system that is more representative of the in vivo state. This culture system will be of interest to a broad range of neuroscientists as it provides a simplified and tractable system to study the functions and properties of astrocytes both in the normal and diseased states.
  • 2008
    Giering, Jeffery C.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2002 ScienceDirect
    Eccles, Jacquelynne S.; Wigfield, Allan.
    This book discusses research and theory on how motivation changes as children progress through school, gender differences in motivation, and motivational differences as an aspect of ethnicity. Motivation is discussed within the context of school achievement as well as athletic and musical performance.
  • 2012 Springer
    Bornstein, Gadi G.; Klakamp, Scott L.; Tabrizi, Mohammad A.
    1. Translational Strategies for Development of Antibody-Based Therapeutics: An Overview / Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp -- 2. Discovery Process for Antibody-Based Therapeutics / Heather H. Shih -- 3. Technologies for the Generation of Human Antibodies / Ramesh R. Bhatt, John S. Haurum and C. Geoffrey Davis -- 4. Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics / Randall J. Brezski and Juan Carlos Almagro -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics / Andrew W. Drake and Giuseppe A. Papalia -- 6. Considerations in Establishing Affinity Design Goals for Development of Antibody-Based Therapeutics / Mohammad Tabrizi -- 7. Bioanalytical Considerations for Development of Antibody-Based Therapeutics: Pharmacokinetics and Immunogenicity / Cherryl B. Funelas and Scott L. Klakamp -- 8. Preclinical Considerations for Development of Antibody-Based Therapeutics in Oncology / Gregory Landes and Kathleen Elias -- 9. Factors Impacting the Tumor Localization and Distribution of Antibody-Based Therapeutics in Oncology / David C. Blakey -- 10. Preclinical Safety Considerations for the Development of Antibody-Based Therapeutics / Lolke de Haan -- 11. Application of Pharmacokinetic/Pharmacodynamic Modeling in the Development of Antibody-Based Therapeutics / Donald E. Mager -- 12. Application of Population Pharmacokinetic-Pharmacodynamic Approaches in the Design of Translational Strategies for Development of Antibody-Based Therapeutics / Feng Jin -- 13. Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics / Mohammad A. Tabrizi and Cherryl B. Funelas -- 14. Translational Research in Alzheimer's Disease for Development of Antibody-Based Therapeutics / Eric C. Yuen, Enchi Liu and Gene G. Kinney -- 15. Considerations in Manufacturing Process Development for Antibody-Based Therapeutics / Paula C. Miller and Peiling Xu -- 16. Strategies for Development of Next Generation Antibody-Based Therapeutics / Mohammad Tabrizi and Gadi Gazit Bornstein -- 17. Immune Complex Therapies for Treatment of Immune Thrombocytopenia / Rong Deng and Joseph P. Balthasar -- 18. Application of Bioinformatics Principles for Target Evaluation / Anthony Carvalloza, Mohammad Fallahi and Sahba Tabrizifard -- 19. Concluding Remarks / Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp.
  • 2015 Wellcome Trust
    Overy, Caroline; Tansey, E. M.
  • 2007
    Okamoto, Tsutomu; Okamoto, Kayoko.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012
    Peacock, Ryan Ward Streble; Khosla, Chaitan; Sage, Julien; Wang, Clifford.
    Studying the effects of gene expression in biological systems has traditionally been undertaken by measuring phenotypic response at a limited number of expression levels. Typically the effects of gene expression are assayed at a high level of overexpression and compared to physiological levels of expression; however, many examples exist in which the level of gene expression greatly affects the resulting cellular phenotypes. Of particular interest for our purposes is the interplay between oncogenes in driving tumorigenesis and cancer progression. For example, oncogene H-Ras is capable of both enhancing cellular proliferation at intermediate levels expression levels (doses) and causing cell cycle arrest and senescence at high expression levels. In order to more thoroughly investigate such behavior we have created a set of tools for measuring dose-dependent effects of gene expression. These tools consist of promoter library to drive wide range gene expression, single-cell proliferation measurements, and data analysis methods to calculate correlation curves between gene expression level and phenotype response. The system is designed for cell-by-cell measuring of both expression level and phenotype response by flow cytometry. This approach allows for full dose experiments to be performed in a single heterogeneous culture with individual cells accessing different expression levels for a given phenotype. Because we are interested in studying the cell biology and genetics of tumor cells, measuring the phenotype of proliferation rate was of particular interest. To aid in further investigation of proliferation rate response to gene overexpression a genetic proliferation reporter was developed. This reporter utilizes the cell cycle-dependent activity of the E2F class of transcription factors, which are active during the G1/S transition. The highly stable fluorescent proteins EGFP and mCherry are expressed from both an E2F-responsive and constitutive promoter, respectively. The ratio of fluorescence levels correlates to proliferation rate in a variety of cell lines, matching predictions made initially by computational model. Finally, given a culture containing expression of a gene or combination of genes by the promoter library and phenotype measurement, the data collected from those cells must be analyzed to determine a correlation curve representing the dose response of the phenotype to level of expression of the genes of interest. In order to calculate this curve from the flow cytometry data several empirical analysis methods were evaluated. We determined the locally weighted scatter plot smoothing (LOWESS) curve fitting method to be best for our purposes of fitting the dose-response curves. As the LOWESS fits of flow cytometry data represented a technical hurdle to performing the dose-response experiments a custom software package was created to allow for easy implementation of the constitutive promoter library for studying dose-dependent behavior. The result is a set of biological and computational tools that allow for high throughput evaluation of gene dose effects. Further effort has been undertaken to move the system to evaluate multiple genes simultaneously, with the ultimate goal of being able to measure genetic cooperation.
  • 2013
    Ferreira, Joshua P.; Cimprich, Karlene; Spormann, Alfred M.; Wang, Clifford.
    Cancer arises from the alteration of genes and the deregulation of the inherent control mechanisms existing with a cell. Cancer progression is the result of several of these genes or pathways being altered. Unfortunately, its analysis is not as straightforward as identifying a handful of discrete, independent mutational events occurring within a cell. Rather, these genes, pathways, and other regulatory elements are interconnected. Altering the expression level (dose) of one gene can have direct and indirect effects on many additional genes/pathways. Furthermore, combinations of genes can interact to have collaborative or antagonistic effects that are greater than or less than the sum of their individual contributions. It is not enough to study the effects of single genes/pathways at a few discrete expression levels. To this end, we have developed genetic tools that allow for controlling gene expression over a full range. Controlling gene expression at the level of transcription allowed for a 40-fold range of expression to be investigated. However, the range in expression of the transcriptionally controlled system varied across cell lines. Expanding beyond this system, we have turned to controlling gene expression at the level of translation. Using translational control elements, we were able to varying gene expression over a 200 -- 300-fold range. Furthermore, the translational control system was shown to be consistent across six different cell lines and with every transgene that has been tested to date. To address the fact that cancer progression is a multi-faceted event, we developed a system that would allow observation of the effects resulting from the interactions of multiple genes. By using retroviral vectors equipped with fluorescent protein fusions, we successfully derived a system that has the capacity to interrogate up to three genes of interest within a single culture of cells. This single culture makes it logistically feasible to study such large combinations of gene dosage levels. This single culture is heterogeneous in expression for each of the transgenes introduced; and by utilizing flow cytometry, the precise dosage level of each transgene can be correlated to measureable phenotypes at the single-cell level. To demonstrate how the tools we have developed can be utilized to quantitatively assess gene-dosage profiles, we ectopically controlled the expression of various mutant forms of the oncogenic version of H-Ras (H-RasG12V) in both murine fibroblast and pre-B cells. We chose to study proliferation as a measurable phenotypic read-out. In NIH/3T3 fibroblasts we observed a maximum in proliferation at low levels of expression of H-RasG12V. A mutant version, H-RasG12V T35S, which is only able to signal down the MAPK pathway, exhibited maximal proliferation at intermediate expression levels. Other H-Ras mutants did not exhibit any proliferation optima when expressed by themselves. In contrast, when the mutants were investigated in pairwise fashion, some cooperation could be observed between particular mutant pairs. Finally, the effect of these H-Ras mutants on proliferation was investigated in a murine pre-B cell line. By adding a reference population of cells to a culture of cells expressing H-Ras mutant oncogenes over a range of expression levels, we were able to track the population dynamics between these two subsets of cells. A simple mathematical approach will be detailed to demonstrate how we can calculate the net proliferation rate as a function of H-Ras expression level by tracking the distribution of these two cell populations over time.
  • 2014 Springer
    Gieschke, Ronald; Serafin, Daniel.
    The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?
  • 2006
    Kanter, Jennifer Lynn.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011
    Cocker, Eric David; El Gamal, Abbas A.; Kenny, Thomas W.; Schnitzer, Mark Jacob.
    A central goal in neuroscience is to explain animal behavior in terms of causal cellular processes. It has been a longstanding challenge, however, to simultaneously track behavior and the cellular dynamics driving it. In this thesis, I discuss how a series of one- and two-photon fluorescence microscopes, based on gradient refractive index (GRIN) lenses, were developed to meet this challenge. The predominant difficulty in the design of these microscopes was how to take a traditional bench top microscope and shrink it to a size small enough for a mouse to easily carry on its head, a limit of 3 grams. We chose mice as our design target due to the wide availability of genetically modified mouse models for the study of cognitive functions, animal behaviors, and disorders of the nervous system. The earlier devices, relying on fiber optics to bring light to and from the animal, met with limited success but still provided useful insight in the development of the surgical techniques and analytical tools necessary for later successful experiments. In contrast, our latest system fully integrates the entire light pathway onto the head of mouse, eliminating many of the remaining roadblocks to truly freely-moving imaging. This device has enabled novel observations of both microcirculatory and neuronal calcium dynamics in the cerebellum of freely-moving mice at frame rates up to 100 Hz. As the genetic toolbox for mice continues to mature, these miniaturized microscopes will facilitate a wide set of future studies of how cellular function in the brain varies across different behavioral and physiological states.
  • 2015 Wellcome Trust
    Jones, Emma M.; Tansey, E. M.
  • 2010 Springer
    Piontelli, Alessandra.
    General movements -- Startles, twitches and clonuses -- Hiccups, yawning and gasping -- Fetal breathing movements -- Swallowing, sucking and handedness as inferred from fetal thumb sucking -- Localized movements -- Facial expressions -- Rest-activity cycles, clusters and the ontogeny of sleep -- Twin fetuses and twin myths -- Conclusions: movement is life.
  • 2015 Springer
    Piontelli, Alessandra.
  • 2012 Springer
    Gabain, Alexander von; Klade, Christoph.
    Development of novel vaccines gives an overview of the tasks in basic research leading to the final product â" the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
  • Wellcome Trust
    Reynolds, L. A.; Tansey, E. M.
  • 2009 Wellcome Trust
    Reynolds, L. A.; Tansey, E. M.
  • 2011
    Lee, Jungjoon Kempthorne; Huestis, Wray H.; Moerner, W. E.; Rao, Jianghong.
    The development of live cell RNA imaging techniques will lead to the unraveling of many important biological processes. To achieve this goal, there have been three different strategies developed. They are the development of small molecule probes, nucleic acid probes, and green fluorescent protein (GFP) probes. In the following thesis, the pros and cons of each approach are discussed, followed by a proposal to resolve the limitations. In the small molecule case, a probe was developed that utilized a quenched sulforhodamine dye. It was designed so that its structure can be rationally modified from the initial lead compound. An aptamer sequence that activates the sulforhodamine probe with micro molar affinity was found by in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX), followed by fluorescence screening in E.coli. The rational modification of the structure of the initial sulforhodamine probe resulted in an overall 33-fold increase in binding affinity compared to the initial lead compound. Instead of the chemical modification of the lead compound, the small molecule's cell permeability and binding affinity to the target could be improved by linking to cell penetrating peptides (CPP). A CPP is a short peptide sequence composed of poly arginine amino acids which shows excellent cell uptake and affinity to RNA. However, the use of the CPP-linked dye in live cell imaging has been limited by strong signals in the endosome region. An attempt was made to overcome this difficulty by linking a quencher molecule to the dye-CPP via a disulfide bond, which only breaks when it enters the cytosol. For the nucleic acid probe, the major problem was its low cell permeability and low signal-to-background ratio due to the low copy number of mRNA targets within the cell. We made mutant Hammerhead ribozymes and embedded them in a non-coding region of the GFP expression vector that can be transfected to mammalian cells. This modified Hammerhead ribozyme acts as a logic gate, and the signal is amplified by the expression of GFP in the presence of the target mRNA. In vitro and in vivo results are discussed. Finally, a fragmented GFP system, the fluorescence of which could be recovered by binding to a specific RNA tag, was developed. The major problem for the GFP-mediated RNA imaging system was the low signal-to-background ratio from the GFP probe that is not bound to the RNA tag. To find the non-fluorescent GFP, the GFP was truncated from the C-terminus such that it loses its fluorescence with minimum loss of amino acids. An RNA sequence that has high affinity to this GFP was found by in vitro SELEX. The subsequent E.coli screening found an RNA sequence that reactivates the fluorescence of the GFP probe.
  • 2011
    Thompson, Michael Anthony; Boxer, Steven G.; Fayer, Michael D.; Moerner, W. E.
    Fluorescence microscopy is one of the most widely used tools in cell biology due its intrinsically high detection sensitivity coupled with the ability to genetically label proteins and other cellular structures with fluorescent tags. However, the resolution of fluorescence microscopy has historically been limited to about 200 nm laterally and 800 nm axially because of the diffraction limit of visible light. In the past five years, imaging below the diffraction limit ("super-resolution imaging") by localizing single fluorophores, one at a time (1-3), has opened a wide a variety of new biological systems for study. This Dissertation is a collection of both techniques for two and three dimensional super-resolution imaging as well as applications in bacterial and yeast imaging. References 1. Betzig E, et al (2006) Imaging intracellular fluorescent proteins at nanometer resolution. Science 313: 1642-1645. 2. Hess ST, Girirajan TPK & Mason MD (2006) Ultra-high resolution imaging by fluorescence photoactivation localization microscopy. Biophys J 91: 4258-4272. 3. Rust MJ, Bates M & Zhuang X (2006) Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat Methods 3: 793-795.
  • 2010
    Franzini, Raphael Marcel; Du Bois, Justin; Huestis, Wray H.; Kool, Eric T.
    Templated fluorescence activation is an elegant nucleic acid detection technique, which relies on a target-activated chemical reaction between two oligonucleotide probes, eliciting a fluorescence readout. This method reports on genetic markers in solution phase and in cells. The research described in this thesis was aimed to expand the reaction scope of templated fluorescence activation and to develop probes, which overcome shortcomings of previous designs. Examples of DNA template-mediated fluorogenic reactions developed during this project include an organomercury-induced cyclization of Rhodamine thiosemicarbazide and the deprotection of a 7-azidomethoxycoumarin profluorophore by a Staudinger reaction. The most promising probe design (Q-STAR probes) is based on the reductive cleavage of an [alpha]-azidoether quencher release linker conjugated to a fluorophored-labeled DNA. A triphenylphosphine DNA-probe rapidly activates Q-STAR probes in the presence of the matched DNA target strand, reporting its presence by a strong fluorescence turn-on signal. Q-STAR probes are inert to aqueous conditions and cellular components, properties that were suboptimal for previous probe designs. Q-STAR probes report the target with single nucleotide specificity and enable an amplified detection signal by harnessing the target as a catalyst for the templated reaction. Q-STAR probes efficiently detect the presence of rRNAs in bacteria and mammalian cells. The probes are responsive to single nucleotide differences, which allows discriminating bacteria species by genetic variations using fluorescence microscopy or flow cytometry. Similarly, rRNAs in mammalian cells generate a strong fluorescence turn-on signal for Q-STAR probes. Templated fluorescence activation schemes bear considerable promise for applications in clinical diagnostics and molecular biology. The probe designs described in this thesis, in particular Q-STAR probes, constitute a major advancement in the field and will help achieve these goals.
  • 2005 Springer
    Kelley, Matthew.
  • 2007/2008
    Metzger, Ross Jay.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 Karger
    Scharfmann, R.; Shield, J. P. H.
    Pancreatic development as a basis for the definition of new therapies for diabetes / Scharfmann, R. -- Overview of neonatal diabetes / Hamilton-Shield, J.P. -- Transcription factors in pancreatic development. Animal models / Martin, M. ... [et al.] -- Distinct roles of HNF1[beta], HNF1[alpha], and HNF4[alpha] in regulating pancreas development, [beta]-cell function, and growth / Maestro, M.A. ... [et al.] -- In vivo and in vitro techniques to study pancreas development and islet cell function / Duvillié, B., Heinis, M., Stetsyuk, V. -- Functional imaging of the pancreas: the role of [18F]Fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy / Ribeiro, M.J. ... [et al.] -- Insulin pump therapy in neonatal diabetes / Tubiana-Rufi, N. -- Generating new candidate genes for neonatal diabetes: functional and genetic studies of insulin secretion in type 2 diabetes / Rutter, G.A. -- Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences / Flechtner, I. ... [et al.] -- Genomic imprinting: roles and regulation in development / Kelsey, G. -- Imprinting in human disease with special reference to transient neonatal diabetes and Beckwith-Wiedemann syndrome / Temple, I.K. -- The physiology and clinical management of glucose metabolism in the newborn / Beardsall, K., Dunger, D.
  • 2005 Springer
    Putte, S. C. J. van der.
  • 2015 Wellcome Trust
    Jones, Emma M.; Tansey, E. M.
  • 2006
    Thomason, Moriah Elizabeth.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 CRCnetBASE
    Hood, Ronald D.
  • 2014 Springer
    Kiefer, Friedemann; Schulte-Merker, Stefan.
    "For decades, lymphatic vessels were considered to be of "lesser significance" than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences. Still, many central aspects of the developmental origin, growth control and regulation of lymphatic vessels are not sufficiently understood. This volume of 'Advances in anatomy, embryology, and cell biology' focuses on the lymphatic vascular system from a developmental point of view, presenting exciting recent advances in elucidating the development and molecular control of lymphatic vessels. A collection of focused reviews, written by respected experts, describes ostensively how advanced genetic models and state-of-the-art imaging are being used to decipher the action of transcriptional programs, growth factors and matrix components in the regulation of lymphatic endothelial cell behavior. A synopsis is provided for each chapter, concisely highlighting the main points"--Publisher's description.
  • 2012 Karger
    Mullis, P.-E.
  • 2005 Springer
    Macieira-Coelho, Alvaro.
    The hedgehog signaling pathway in cancer / J. Vestergaard, Mads Bak, L.A. Larsen -- Rho GTPases and cancer / P. Buongiorno, B. Bapat -- Developmental biology of fibroblasts and neoplastic disease / D. Brouty-Boyé -- The extracellular matrix during normal development and neoplastic growth / J. Labat-Robert, L. Robert -- Wilms' tumor : starting off the kidney all over again? / M. Little -- Testicular teratomas : back to pluripotent stem cells / T. Kimura ... [et al.] / Tumor suppressors APC and VHL : gatekeepers of the intestine and kidney / R.H. Giles, E.E. Voest -- Hormonal and stromal regulation of normal and neoplastic prostatic growth / W.A. Ricke ... [et al.] -- Neoplastic growth through the developmental stages of the organism / A. Maciera-Coelho.
    Also available: Print – 2005
  • 2011 Springer
    Balogh, Péter.
    Common themes in lymphoid organ development -- Development of lymph nodes in humans and rodents -- Programmed and nascent gut-associated organized lymphoid tissues -- Single complexity : the spleen -- Dsassembling the puzzle : effect of aging.
  • 2006
    Gilbert, Scott F.; Kozlowski, Ronald N.; Singer, Susan R.; Tyler, Mary S.
  • 2013
    Clarke, Shoa Long; Bejerano, Gill; Bustamante, Carlos; Fuller, Margaret T.; Snyder, Michael.
    In this work, I present two studies of the evolution and function of developmental enhancers. In the first study, I describe the discovery of the first examples of cis-regulatory elements that are conserved across the two great clades of the bilaterian tree (deuterostomes and protostomes). These bilaterian conserved regulatory elements (Bicores) are developmental enhancers that respond to key signaling pathways and have been conserved for approximately 650 million years. In vertebrates, Bicores have neofunctionalized to drive expression in the central nervous system. In the second study, I present a genome-wide set of putative enhancers that function in the development of the mammalian neocortex. These elements, identified through ChIP-seq, are validated through both computational and experimental approaches. I show that many elements are anciently conserved beyond mammals, and we show that older elements are more likely to be pleiotropic. Pleiotropic elements most likely function in other aspects of central nervous system development, and elements that are conserved to zebrafish function in the developing zebrafish forebrain. I also provide evidence that specific repeat families have played a major role in the generation of enhancers that function in neocortex development. Finally, in the conclusion, I discuss how enhancer neofunctionalization and pleiotropy fit into a model of enhancer evolution and the evo-devo framework.
  • 2005 CRCnetBASE
    Holladay, Steven D.
  • 2005 Springer
    Jacobson, Marcus; Rao, Mahendra S.
    Also available: Print – 2005
  • 2010 Springer
    Pallas, Sarah L.
  • v. 1-3, 2006.
    Cicchetti, Dante; Cohen, Donald J.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Theory and method -- v. 2. Developmental neuroscience -- v. 3. Risk, disorder, and adaptation.
  • 1973-
    O'Rahilly, Ronan.
    PrintStatus: Not Checked OutLane Catalog Record
    Part A. Embryos of the first three weeks (stages 1 to 9).
  • v. 1-<3>, 1988-<1991>
    Gottlieb, Marvin I.; Williams, John E.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 ClinicalKey
    Carey, William B.; Coleman, William Lord; Crocker, Allen C.; Elias, Ellen Roy; Feldman, Heidi M.
    Also available: Print – 2009
  • v. 39, 2005. Springer
  • 2010 Springer
    Maisel, William H.
    Pathophysiology of heart failure / M. Velez and N.K. Sweitzer -- Medical therapy for heart failure / N.K. Lakdawala and A. Desai -- Device trials in chronic heart failure: Implications of trial design / W.K. Laskey and R. Manring-Day -- The FDA perspective on heart failure devices / M.G. Hillebrenner ... [et al.] -- Hemodynamic monitoring in heart failure / A. Nohria and A. Bhatt -- Implantable cardioverter-defibrillators / R. Lampert and Z. Goldberger -- Cardiac resynchronization therapy / D. Frisch and P.J. Zimetbaum -- Pacing and defibrillation for atrial arrhythmias / J.M. Cooper -- Atrial fibrillation ablation / J.V. Wylie and M.E. Josephson -- Percutaneous treatment of coronary artery disease / R.J. Laham -- Percutaneous management of peripheral arterial disease / M.A. Sheikh and L.A. Garcia -- Percutaneous management of valvular heart disease / J.J. Wykrzykowska and J.P. Carrozza -- Ventricular assist devices and total artificial hearts / A. Blitz and J.C. Fang -- Device therapy for left ventricular dysfunction / C.W. Yancy.
  • 2006
    Anderson, Julie; Timmermann, Carsten.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008 Springer
    Barold, S. Serge; Ritter, Ph.
    Indications and implantation for cardiac resynchronization therapy -- Do the official guidelines for cardiac resynchronization therapy need to be changed? -- Alternative techniques for left ventricular lead placement -- Importance of the right ventricular pacing site in cardiac resynchronization -- Alternative means of achieving cardiac resynchronization -- CRT-pacing only versus CRT-defibrillator -- Upgrading conventional pacemakers to CRT: indications and technical considerations -- Cardiac resynchronization for heart failure -- Update of cardiac resynchronization trials -- Cardiac resynchronization for heart failure: do we need more trials? -- Should cardiac resynchronization be considered for the prevention of heart failure? -- Left bundle branch block-induced cardiomyopathy: a new concept of mechanically induced cardiomyopathy -- Role of echocardiography before CRT implantation: can we predict nonresponders? -- Role of echocardiography after implantation of a cardiac resynchronization system -- Advances in technology -- Recent advances in the technology of cardiac resynchronization therapy -- Advances in left ventricular pacing leads -- New pacing algorithms and functions in CRT devices -- Significance of latency during left ventricular pacing for cardiac resynchronization therapy -- Programmability of the interventricular interval during cardiac resynchronization therapy -- Hemodynamic sensors in heart failure devices -- Assessment of single-shock defibrillation testing of biventricular ICDs -- Follow-up -- How to program CRT devices -- Programming and follow-up of CRT and CRTD devices -- Standard electrocardiogram during cardiac resynchronization -- Cardiac arrhythmias after cardiac resynchronization -- Advances in CRT device diagnostics -- Complex issues in the follow-up of CRT devices -- Recurrent heart failure and appropriate evaluation after cardiac resynchronization therapy.
  • Felton, Mark.
  • 2012 Ovid
    Govindan, Ramaswamy.
  • 2011 Ovid
    De Pinho, Ronald A.; DeVita, Vincent T.; Hellman, Samuel; Lawrence, Theodore S.; Rosenberg, Steven A.; Weinberg, Robert A.
    The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging -- Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas -- Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.
  • 2008 (8th ed.) Ovid
    DeVita, Vincent T.; Hellman, Samuel; Lawrence, Theodore S.; Rosenberg, Steven A.
    Also available: Print – v. 1-2., 2008
  • 2015 Ovid
    DeVita, Vincent T.; Hellman, Samuel; Lawrence, Theodore S.; Rosenberg, Steven A.
    Also available: Print – 2015
  • 2007
    Dewhurst, John; Edmonds, D. Keith.
    PrintStatus: Not Checked OutLane Catalog Record
    Clinical anatomy of the pelvis and reproductive tract / Alan Farthing -- Maternal physiology / Fiona Broughton-Pipkin -- The placenta and fetal membranes / Berthold Huppertz and John C.P. Kingdom -- Normal fetal growth / Jason Gardosi -- Pre-conception counselling / Andrew McCarthy -- Antenatal care / Timothy G. Overton -- Normal labour / A.A. Calder -- Fetal monitoring during labour / James A. Low -- Analgesia and anaesthesia / John A. Crowhurst -- Puerperium and lactation / D. Keith Edmonds -- Neonatal care for obstetricians / M.A. Thomson and A.D. Edwards -- Spontaneous miscarriage / Joanne Topping and Roy G. Farquarson -- Recurrent miscarriage / Raj Rai -- Ectopic pregnancy / Davor Jurkovic -- Trophoblast disease / Philip Savage and Michael Seckl -- Prenatal diagnosis and genetics / Sailesh Kumar -- Fetal medicine in clinical practice / R.C. Wimalasundera -- Obstetric emergencies / Sara Paterson-Brown -- Disorders of fetal growth and assessment of fetal well-being / G.C.S. Smith and C.C. Lees -- Multiple pregnancy / Nicholas M. Fisk -- Preterm labour / Philip Bennett -- Prolonged pregnancy / Patricia Crowley -- Induction and augmentation of labour / G. Justus Hofmeyr -- Malpresentation, malposition, cephalopelvic disproportion and obstetric procedures / S. Arulkumaran -- Hypertensive disorders / Andrew Shennan -- Heart disease in pregnancy / Catherine Nelson-Piercy -- Diabetes and endocrine disease in pregnancy / Anne Dornhorst and Catherine Williamson -- Renal disease / John Davison -- Haematological problems in pregnancy / P. Clark, A.J. Thomson and I.A. Greer -- Miscellaneous medical disorders / Andrew McCarthy -- Obstetric statistics / Jim G. Thornton -- Contraception / Anna Glasier -- Termination of pregnancy / Gillian Flett and Allen Templeton -- Normal and abnormal development of the genital tract / D. Keith Edmonds -- The menstrual cycle / William L. Ledger -- The role of ultrasound in gynaecology / Joanne Topping -- Gynaecological disorders of childhood and adolescence / D. Keith Edmonds -- Primary amenorrhoea / D. Keith Edmonds -- Polycystic ovarian syndrome and secondary amenorrhoea / Adam H. Balen -- Menstrual problems: menorrhagia and primary dysmenorrhoea / Margaret C.P. Rees -- Premenstrual syndrome / P.M.S. O'Brien -- Pelvic infection / Jonathan D.C. Ross and Peter Stewart -- Chronic pelvic pain / R. William Stones -- Endometriosis / Stephen Kennedy and Philippe Koninckx -- Infertility / Siladitya Bhattacharya -- Assisted reproduction / Geoffrey Trew -- Menopause and the postmenopausal woman / Nick Panay -- Pelvic floor dysfunction I: uterovaginal prolapse / Anthony R.B. Smith -- Urninary incontinence / D. Robinson and L. Cardozo -- Hysteroscopy and laparoscopy / Adam Magos -- Benign disease of the vulva / Richard Staughton -- Malignant disease of the vulva and vagina / David M. Luesley -- Benign diseases of the vagina, cervix and ovary / D. Keith Edmonds -- Premalignant and malignant disease of the cervix / Mahmood I. Shafi -- Epithelial ovarian cancer / Hani Gabra -- Benign disease of the uterus / Mary Ann Lumsden -- Cancer of the uterine corpus / Henry C. Kitchener -- Sexual dysfunction / Fran Reader -- Ethical dilemmas in obstetrics and gynaecology / Gordon M. Stirrat -- The law and the obstetrician and gynaecologist / Bertie Leigh -- Domestic violence and sexual assault / Maureen Dalton.
  • 2012 CRCnetBASE
    Watson, Ronald R.
    "Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study."--Publisher's description.
  • 2012 Springer
    Ahmad, Shamim I.
    Also available: Print – 2012
  • 2012 Springer
    Sima, Anders A. F.
    1. C-Peptide and Insulin: A Happy Marriage / Donald F. Steiner -- 2. Peptide Interactions of Proinsulin C-Peptide / Charlotte Nerelius, Emma Lindahl, Michael Landreh, and Hans Jörnvall -- 3. The Effect of Combined C-Peptide and Zinc on Cellular Function / Dana M. Spence -- 4. C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy / Nigel J. Brunskill -- 5. Role of C-Peptide in the Regulation of Microvascular Blood Flow / Thomas Forst, Matthias M. Weber, Thomas Kunt, and Andreas Pfützner -- 6. Is NO-eNOS a Target for C-Peptide Action and Its Protective Effects on Diabetic Nephropathy? / Kazuhiro Kimura and Akihiro Kamikawa -- 7. Renoprotective Effects of C-Peptide on Type 1 Diabetes / Lina Nordquist, Åsa Kallas, Sara Stridh, Fredrik Palm, and John Wahren -- 8. The Mechanisms Underlying the Effects of C-Peptideon Type 1 Diabetic Neuropathy / Hideki Kamiya, Wei-Xian Zhang, and Anders A.F. Sima -- 9. C-Peptide and Type 1 Diabetic Encephalopathy / Anders A.F. Sima and Wei-Xian Zhang -- 10. C-Peptide: A New Moleculewith Anti-Inflammatory Properties / Jaime Haidet, Vincenza Cifarelli, Xuehui Geng, Massimo Trucco, and Patrizia Luppi -- 11. C-Peptide: Connecting Diabetes with Macrovascular Complications / Karen E. Porter and Romana S. Mughal -- 12. C-Peptide and Diabetic Neuropathy in Patients with Type 1 Diabetes / Karin Ekberg and John Wahren -- 13. Proatherogenic Effects of C-Peptide / Daniel Walcher and Nikolaus Marx -- 14. Conclusions and Future Outlook / Anders A.F. Sima.
  • 2014 ScienceDirect
    Preedy, Victor R.
  • 2011 Springer
    Schwanstecher, Mathias.
    Targeting type 2 diabetes -- Dual acting and pan-PPAR activators as potential anti-diabetic therapies -- GLP-1 agonists and dipeptidyl-peptidase IV inhibitors -- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes -- SGLT inhibitors as new therapeutic tools in the treatment of diabetes -- Inhibitors of 11[beta]-hydroxysteroid dehydrogenase type 1 in antidiabetic therapy -- Nampt and its potential role in inflammation and type 2 diabetes -- Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance -- Overcoming insulin resistance with ciliary neurotrophic factor -- Thermogenesis and related metabolic targets in anti-diabetic therapy -- Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes -- Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes -- AMP-activated protein kinase and metabolic control -- Mitochondria as potential targets in antidiabetic therapy -- Research and development of glucokinase activators for diabetes therapy : theoretical and practical aspects.
  • 2008 Karger
    Masur, K.; Thévenod, F.; Zänker, Kurt S.
  • 2015 Springer
    Paneni, Francesco; Cosentino, Francesco.
    This book provides a practical hands-on approach to the management of patients with diabetes and cardiovascular disease, with original and up-to-date coverage of a variety of aspects of emerging clinical importance. Practical advice is offered on diagnosis, risk stratification, management of cardiovascular risk factors, and available drug therapies. Appropriate myocardial revascularization strategies are explained, and the current state of knowledge is documented regarding target-led multifactorial treatment and the management of acute coronary syndromes, heart failure, and cerebrovascular disease. New algorithms for diagnosis and treatment are presented, and to ensure ease of reference each chapter includes a box with practical recommendations as well as informative color illustrations and tables. The handbook will be of value for all cardiologists and diabetologists and will be especially helpful for young cardiologists, who are ever more frequently confronted by patients with diabetes and cardiovascular disease.
  • 2005 Springer
    Johnstone, Michael T.; Veves, Aristidis.
    1. Effects of insulin on the vascular system / Helmut O. Steinberg -- 2. Effects of diabetes and insulin resistance on endothelial functions / Zhiheng He, Keiko Naruse, and George L. King -- 3. Diabetes and advanced glycoxidation end-products / Melpomeni Peppa, Jaime Uribarri, and Helen Vlassara -- 4. The renin-angiotensin system in diabetic cardiovascular complications / Edward P. Feener -- 5. PPARs and their emerging role in vascular biology, inflammation, and atherosclerosis / Jorge Plutzky -- 6. Diabetes and thrombosis / David J. Schneider and Burton E. sobel -- 7. Role of estrogens in vascular disease in diabetes: lessons learned from the polycystic ovary syndrome / Agathocles Tsatsoulis and Panayiotic Economides -- 8. Poly(ADP-ribose) polymerase activation and nitrosative stress in the development of cardiovascular disease in diabetes / Pál Pacher and Csaba Szabó -- 9. Adiponectin and the cardiovascular system / Suketu Shah, Alina Gavrila, and Christos S. Mantzoros -- 10. Nitric oxide and its role in diabetes mellitus / Michael T. Johnstone and Eli Gelfand -- 11. Diabetes and atherosclerosis / Maria F. Lopes-Virella and Gabriel Virella -- 12. The use of animal models to study diabetes and atherosclerosis and potential anti-atherosclerotic therapies / Peter D. Reaven and Wulf Palinski -- 13. The metabolic syndrome and vascular disease / S.J. Creely, Aresh J. Anwar, and Sudhesh Kumar -- 14. Diabetes and hypertension / Samy I. McFarlane ... [et al.] -- 15. Diabetes and dyslipidemia / Asha Thomas-Geevarghese, Catherine Tuck, and Henry N. Ginsberg -- 16. Diabetic retinopathy / Lloyd Paul Aiello and Jerry Cavallerano -- 17. Diabetic nephropathy / Richard J. Solomon and Bijan Roshan -- 18. Diabetic neuropathy / Rayaz A. Malik and Aristidis Veves -- 19. Microcirculation of the diabetic foot / Chantel Hile and Aristidis Veves -- 20. Epidemiology of peripheral vascular disease / Stephanie G. Wheeler, Nicholas L. Smith, and Edward J. Boyko -- 21. Noninvasive methods in assess vascular function and pathophysiology / Peter G. Danias and Rola Saouaf -- 22. Peripheral vascular disease in patients with diabetes mellitus / Bernadette Aulivola, Allen D. Hamdan, and Frank W. LoGerfo -- 23. Therapeutic interventions to improve endothelial function in diabetes / Lalita Khaodhiar and Aristidis Veves -- 24. Preoperative assessment and perioperative management of the surgical patient with diabetes mellitus / Alanna Coolong and Mylan C. Cohen -- 25. Diabetes and percutaneous interventional therapy / David P. Oorenz, Joseph P. Carrozza, and Lawrence Garcia -- 26. Cardiac surgery and diabetes mellitus / Tanveer A. Khan, Pierre Voisine, and Frank W. Sellke -- 27. Heart failure and cardiac dysfunction in diabetes / Lawrence H. Young, Raymond R. Russell, III, and Deborah Chyun -- 28. Diabetes mellitus and heart disease / Michael T. Johnstone and George P. Kinzfogl.
  • 2009 Springer
    Regensteiner, Judith G.; Reusch, Jane E. B.; Stewart, Kerry J.; Veves, Aristidis.
  • 2012 Springer
    Bakris, George L.; McFarlane, Samy I.
    Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
  • 2014 Springer
    Batuman, Vecihi; Lerma, Edgar V.
    "Diabetes and Kidney Disease reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are covered, as well as an overview to the novel approaches being designed by leading researchers in the field. A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease."--Publisher's website.
  • 2012 Springer
    McKinsey, James; Shrikhande, Gautam V.
    In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.
  • 2014 Karger
    Goedecke, Julia H.; Ojuka, Edward O.
    The relationship between exercise, nutrition, and type 2 diabetes / Stephenson, E.J., Smiles, W., Hawley, J.A. -- Sedentary behavior as a mediator of type 2 diabetes / Hamilton, M.T., Hamilton, D.G., Zderic, T.W. -- Increasing prevalence of type 2 diabetes in sub-Saharan Africa : not only a case of inadequate physical activity / Ojuka, E., Goyaram, V. -- Exercise interventions to prevent and manage type 2 diabetes : physiological mechanisms / Dela, F., Prats, C., Helge, J.W. -- Relationships between exercise, mitochondrial biogenesis, and type 2 diabetes / Joseph, A.-M., Hood, D.A. -- Interaction between lipid availability, endurance exercise, and insulin sensitivity / Newsom, S.A., Schenk, S. -- Mechanisms in exercise-induced increase in glucose disposal in skeletal muscle / Ojuka, E., Goyaram, V. -- The effect of exercise on obesity, body fat distribution and risk for type 2 diabetes / Goedecke, J.H., Micklesfield, L.K. -- Gene-physical activity interactions and their impact on diabetes / Kilpelinen, T.O., Franks, P.W. -- Physical activity and gestational diabetes mellitus / van Poppel, M.N.M., Ruchat, S.-M., Mottola, M.F. -- Physical activity in children : prevention of obesity and type 2 diabetes / Rush, E., Simmons, D. -- Diabetes and exercise in the elderly / Ferriolli, E., Pinheiro Amador S., Pessanha, F., Lemos S. Marchesi, J.C. -- Public health recommendations for physical activity in the prevention of type 2 diabetes mellitus / Lambert, E.V., Bull, F. -- Exercise for people with type 1 diabetes / Gallen, I.W.
  • 2009 Springer
    Biessels, Geert Jan; Luchsinger, Jose A.
  • 2011 Karger
    Lai, Kar Neng; Tang, Sydney C. W.
  • 2014 ScienceDirect
    Malik, Rayaz A.; Zochodne, Douglas W.
    This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson's disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.
  • 2013 Springer
    Taylor, K. W.
    Diabetes, in all of its forms, now constitutes a growing health concern, affecting all segments of the world's population. There is great interest in the factors which influence its etiology and progression. Among these, a number of viruses feature prominently. Hindered by technological limitations, research into this relationship has hitherto been scarce. Recent advances, however, have opened up the field and there is a burgeoning body of literature on the subject. Unfortunately, this literature has been diffuse and often difficult to access.For the first time, this book compiles the views of many of the world's experts in the field. It addresses questions, ranging from how viruses may destroy or modify the function of pancreatic islets; to which viruses are the most likely culprits; to whether vaccines or etiologic therapies might be used to prevent virus-induced diabetes. Diabetes and Viruses is the first comprehensive volume on an important and expanding field of research that is of interest to clinicians, healthcare managers, epidemiologists, veterinarians, and basic scientists.
  • 2012 Springer
    Hawthorne, Gillian.
    The Epidemiology of Diabetes in Older People -- Type 2 Diabetes and Dementia -- Depression in Older People with Diabetes -- Hypoglycaemia and the Older Person -- Cardiovascular Risk, Glucose and Targets for Management of Diabetes in Older People -- Diabetes and Frailty -- Perceptions of Users and Carers in Supporting Diabetes Care: Practical Guidance, Support and Information for Carers -- Management of Elderly People with Diabetes in Primary Care.
  • 2015 ClinicalKey
    Marx, Nikolaus; McGuire, Darren K.
    Definition and epidemiology of type 2 diabetes mellitus -- Insulin resistance : pathophysiology, molecular mechanisms, genetic insights -- Type 1 diabetes : pathophysiology, molecular mechanisms, genetic insights -- The metabolic syndrome : prevalence and controversies in clinical context -- Lifestyle interventions for the prevention of type 2 diabetes mellitus -- Pharmacologic and surgical interventions that prevent or worsen type 2 diabetes -- Epidemiology of coronary and peripheral atherosclerosis in diabetes -- Pathology of diabetic atherosclerosis : composition, characteristics, and distribution -- Vascular biology of atherosclerosis in patients with diabetes : hyperglycemia, insulin resistance, and hyperinsulinemia -- Vascular biology of atherosclerosis in patients with diabetes : dyslipidemia, hypercoagulability, endothelial dysfunction, and inflammation -- Type 1 diabetes and associated cardiovascular risk and disease -- Effect of lifestyle interventions on coronary heart disease risk in patients with diabetes -- Effect of glucose management on coronary heart disease risk in patients with diabetes -- Effect of blood pressure management on coronary heart disease risk in patients with type 2 diabetes -- Effect of lipid management on coronary heart disease risk in patients with diabetes -- Effect of antiplatelet therapy on coronary heart disease risk in patients with diabetes mellitus -- Role of percutaneous coronary intervention in patients with diabetes -- Role of coronary artery bypass surgery in diabetes and perioperative glucose management -- Epidemiology of acute coronary syndromes in patients with diabetes -- Hyperglycemia and acute coronary syndromes : association with outcomes and management -- Antiplatelet and antithrombotic therapy in diabetic patients with acute coronary syndrome -- Role of primary invasive strategy and revascularization in diabetic patients with acute coronary syndromes -- Epidemiology of heart failure in diabetes -- Diabetic cardiomyopathy : mediators and mechanisms -- Prevention of heart failure in patients with diabetes -- Treatment of heart failure in diabetes : systolic dysfunction, diastolic dysfunction, and post-acute coronary syndrome -- Peripheral artery disease in diabetes -- Cerebrovascular disease in patients with diabetes -- Cardiovascular autonomic neuropathy -- Disparities in diabetes risk, cardiovascular consequences, and care : women, ethnic minorities, and the elderly -- The quality chasm : diabetes mellitus.
  • 2005 Karger
    Chiarelli, F.; Dahl-Jørgensen, K.; Kiess, W.
    Etiopathogenetic aspects of type 1 diabetes / Knip, M. -- Susceptibility to type 1 diabetes: genes and mechanisms / Contu, D., Cucca, F. -- Autoimmunity in type 1 diabetes mellitus / Achenbach, P., Ziegler, A.G. -- Neonatal diabetes mellitus / Polak, M., Shield, J. -- Diagnosis and management of MODY in a pediatric setting / Njolstad, P.R., Sovik, O. -- Diabetic ketoacidosis / Brink, S.R. -- Insulin treatment / Kapellen, T.M. -- Medical nutrition therapy of children and adolescents with diabetes / Virtanen, S.M. -- Continuous subcutaneous insulin infusion in childhood and adolescence / Phillip, M., Weintrob, N., Shalitin, S. -- Quality management in pediatric diabetology / Holl, R.W. ... [et al.] -- Sports and physical activity in children and adolescents with type 1 diabetes mellitus / Raile, K. ... [et al.] -- Invasive and noninvasive means of diabetes self-management / Deiss, D., Hartmann, R., Kordonouri, O. -- Adolescence / Dunger, D.B., Acerini, C., Ahmed, M.L. -- Diabetic nephropathy in children and adolescents / Chiarelli, F., Santilli, F. -- Diabetic autonomic and peripheral neuropathy / Donaghue, K.C., Al-Jasser, A., Maguire, A. -- Macrovascular disease / Dahl-Jørgensen, K., Larsen, J.R. -- Hypoglycemia in children and adolescents with type 1 diabetes / Blasetti, A. ... [et al.] -- Diabetic retinopathy in children and adolescents with type 1 diabetes / Bittner, C., Kordonouri, O., Danne, T. -- Complications and consequences / Kapellen, T.M., Klemens, A.G., Kiess, R.W. -- Type 2 diabetes mellitus in childhood / Piscopo, M.A. ... [et al.] -- Beta-cell function replacement by islet transplantation and gene therapy / Falqui, L.L.
  • 2010 Springer
    Fonseca, Vivian A.; Fonseca, Vivian A.; McDuffie, Roberta Harrison; Pendergrass, Merri.
  • 2009 Springer
    Brown, Florence M.; Tsatsoulis, Agathocles; Wyckoff, Jennifer Ann.
  • 2010 Springer
    Christen, Yves; Craft, Suzanne.
  • 2014 Springer
    Chowdhury, Tahseen.
    At a time when clinicians are bombarded with masses of clinical information from numerous sources, and the wide variety of changes/advances in diabetes management, there is a need for a concise, easy-to-read book that provides an up-to-date review of the major advances in management of diabetes, with an evidence-based approach. This book is a collection of short chapters, each focused on a subject related to the management of diabetes and its complications. The chapters are written by acknowledged experts in the field, who are also clinicians dealing with diabetes on a day-to-day basis. The text is highly evidence based and well referenced with reviews of relevant trials. It includes the latest developments in diabetes management, prospects for future therapies and avenues of research, as well as therapies currently undergoing clinical trial. In order to facilitate ease of reading, it has a user-friendly appearance, with multiple headings, illustrations and summary boxes. The primary audience is clinical, including all healthcare professionals involved in the management of diabetes and its complications. This encompasses diabetologists and endocrinologists, family practitioners with an interest in diabetes, specialist nurses, dietitians and podiatrists.
  • 2007 Ovid
    Unger, Jeff.
    Introduction to diabetes -- Diagnosing and managing the metabolic syndrome in adults, children, and adolescents -- Polycystic ovary syndrome -- Managing type 2 diabetes in adults -- Physiologic insulin replacement therapy -- Insulin pump therapy -- Assessing glycemic control using home blood glucose monitoring, continuous glucose sensing, and glycated hemoglobin (A1C) testing -- Management of diabetes in pregnancy, childhood, and adolescence -- Lifestyle interventions for patients with diabetes -- In-patient management of patients with diabetes -- Screening, diagnosis, and management of diabetes-related complications -- Amylin, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase IV (DPP-IV) inhibitors as novel treatments for diabetes -- Managing mental illness in patients with diabetes.
  • 2013 Ovid
    Unger, Jeff; Schwartz, Zac.
    Introduction to diabetes -- Prediabetes -- Lifestyle interventions for patients with diabetes -- Polycystic ovary syndrome -- Prevention, diagnosis, and treatment of microvascular complications: Part 1, diabetic neuropathy -- Prevention, diagnosis and treatment of microvascular complications: Part 2, diabetic nephropathy and diabetic retinopathy -- Exploring the association between diabetes and cardiovascular disease -- Associated disorders of interest to primary care -- Co-managing mental illness in patients with diabetes -- Diagnosis and management of T2DM -- Type 1 diabetes mellitus in adults -- Insulin initiation and intensification for patients with type 2 diabetes -- Insulin pumping and use of continuous glucose sensors in primary care -- Addressing cultural competency in diabetes care.
  • 2014 CRCnetBASE
    Augustine, Robin; George, Anne; Sebastian, Mathew.
    Diabetes and health care: an overview / M. Abhilash and Robin Augustine -- Withania coagulans Dunal: an overview on its up to date antidiabetic investigations / S. Hemalatha, Satyendra K. Prasad, Manish Kumar, and S. D. Dubey -- Evaluation of total phenolics and free radical quenching activity of Glycosmis pentaphylla (Retz.) A. DC. / Rahul Chandran and Thangaraj Parimelazhagan -- Antioxidant, antidiabetic, and chemical composition of Syzygium aqueum leaf extracts / Uma D. Palanisamy and Thamilvaani Manaharan -- Review on novel 2, 4-thiazolidinedione derivatives as potential therapeutic agents for type II diabetes / Gangadhara Angajala and Radhakrishnan Subashini -- Molecular mechanism of S-oxidation of anti-diabetic thiazolidinedione class of drugs: computational approaches to drug metabolism / Nikhil Taxak and P. V. Bharatam -- Role of wound dressings in the management of chronic and acute diabetic wounds / Robin Augustine, Nandakumar Kalarikkal, and Sabu Thomas -- Recent advances in diabetic foot care: the role of footwear and orthosis / G. Saraswathy, Gautham Gopalakrishna, B. N. Das, and Vijay Viswanathan -- Temporal effect of repeated stress on type-2 experimental diabetes / Debapriya Garabadu and Sairam Krishnamurthy -- Sugar rich diet induced insulin resistance and alteration in gut microflora / Prasant Kumar Jena, Shilpa Singh, and Sriram Seshadri -- Prevalence of diabetes mellitus in patients presenting with acute myocardial infarction / Meeakshi Narkhede, Satyanarayan Durgam, Harshal Bhitkar, Swapnil Yadav, and Dilip Mhaisekar -- Development of therapeutic strategy to restore coronary microcirculation and VEGF signaling cascade in diabetes: a novel approach to prevent cardiac complication in diabetes / Subrina Jesmin, Arifur Rahman, Abdullah Al Mamun, Farzana Sohael, Shamima Akter, Yoshio Iwashima, Nobutake Shimojo, Naoto Yamaguchi, Michiaki Hiroe, Taro Mizutani, and Masao Moroi.
  • 2014 Karger
    Ghigo, E.; Porta, M.
    Diabetes from growth hormone excess / Neggers, S.J., van der Lely, A.J. -- Diabetes in growth hormone deficiency / Prodam, F., Zavattaro, M., Caputo, M., Marzullo, P., Aimaretti, G. -- Diabetes associated with glucocorticoid excess / Janssen, J.A.M.J.L., Lamberts, S.W. -- Diabetes in hyperaldosteronism / Crudo, V., Mulatero, P., Monticone, S., Veglio, F. -- Diabetes from catecholamine excess / Mannelli, M., Parenti, G., Zampetti, B., Canu, L., Mannucci, E. -- Diabetes and hyperthyroidism / Mitrou, P., Dimitriadis, G., Raptis, S.A. -- Diabetes secondary to neuroendocrine gastroenteropancreatic tumors / Minuto, F., Ferone, D., Boschetti, M., Albertelli, M., Gatto, F. -- Type 2 diabetes in polycystic ovary syndrome / Pasquali, R., Gambineri, A. -- Diabetes in hyperparathyroidism / Thomas, A., Kautzky-Willer, A. -- Posttransplant diabetes / Secchi, A., Scavini, M. -- Diabetes in pancreatitis, pancreatectomy, and other pancreatic diseases / Tiengo, A., Vigili de Kreutzenberg, S., Del Prato, S. -- Fibrocalculous pancreatic diabetes / Unnikrishnan, R., Mohan, V. -- Diabetes and hemochromatosis / Wood, M.J., Gonsalkorala, E.S., Powell, L.W. -- Secondary diabetes : clinical considerations / Ghigo, E., Guaraldi, F., Porta, M.
  • 2014 Springer
    Dhalla, Naranjan S.; Turan, Belma.
    Part I. Metabolic derangements in diabetic cardiomyopathy -- Part II. Cellular mechanisms of diabetic cardiomyopathy -- Part III. Therapeutic aspects of diabetic cardiomyopathy -- Index.
  • 2012 Springer
    Giurini, John M.; LoGerfo, Frank W.; Veves, Aristidis.
    Clinical features and diagnosis -- Principles of care in the diabetic surgical patient -- Epidemiology and health care cost of diabetic foot problems -- Diabetic polyneuropathy -- Clinical examination and risk classification of the diabetic foot -- Clinical features and diagnosis of peripheral arterial disease -- Imaging of infection in the diabetic foot -- Pathophysiology -- Physiology and pathophysiology of wound healing in diabetes -- Neuropeptides and diabetic wound-healing -- Induced regeneration of skin and peripheral nerves in the adult -- Microvascular changes in the diabetic foot -- Biomechanics of the diabetic foot: the road to foot ulceration -- Diabetic foot ulcers: effects of hypertoxia and stromal-derived factor-1[alpha] on endothelial progenitor cells -- Management of the diabetic foot -- Wound bed preparation of the diabetic foot ulcer -- Foot pressure abnormalities in the diabetic foot -- Proactive wound care -- Local care of diabetic foot ulcers: assessment, dressings, and topical treatments -- Surgical treatment of the ulcerated foot -- Microbiology and treatment of diabetic foot infections -- Lower extremity arterial reconstruction in patients with diabetes mellitus: principles of treatment -- Charcot arthropathy in the diabetic foot -- Soft tissue reconstruction options for the ulcerated or gangrenous diabetic foot -- Amputations and rehabilitation -- Organization and preventive care -- Organization of the diabetic foot care team -- Quality of health care -- Psychosocial and educational implications of diabetic foot complications -- Role of footwear in the prevention of diabetic foot problems.
  • 2006 Springer
    Giurini, John M.; LoGerfo, Frank W.; Veves, Aristidis.
    Introduction to diabetes: principles of care in the surgical patient with diabetes / Peter Sheehan -- Epidemiology and health care costs for diabetic foot problems / Gayle E. Reiber and Lynne V. McFarland -- The evolution of wound healing: from art to science / I. Kelman Cohen -- The wound-healing process / Jeffrey M. Davidson and Luisa DiPietro -- Induced regeneration of skin and peripheral nerves / Eric C. Soller and Ioannis V. Yannas -- Diabetic neuropathy / Solomon Tesfaye -- Microvascular changes in the diabetic foot / Thanh Dinh and Aristidis Veves -- Clinical features and diagnosis of macrovascular disease / Chantel Hile ... [et al.] -- Foot pressure abnormalities in the diabetic foot / Thomas E. Lyons, Barry I. Rosenblum, and Aristidis Veves -- Biomechanics of the diabetic foot: the road to foot ulceration / C.H.M. van Schie and A.J.M. Boulton -- Clinical examination of the diabetic foot and the identification of the at-risk patient / Stephanie Wu ... [et al.] -- Imaging of the diabetic foot / Mary G. Hochman ... [et al.] -- Microbiology and treatment of diabetic foot infections / Adolf W. Karchmer -- Charcot arthropathy in the diabetic foot / Robert G. Frykberg -- Preparation of the wound bed of the diabetic foot ulcer / Vincent Falanga -- Local care of diabetic foot ulcers: assessment, dressings, and topical treatments / Oscar M. Alvarez, Lee Markowitz, and Martin Wendelken -- Surgical treatment of the ulcerated foot / John M. Giurini -- Amputation and rehabilitation of the diabetic foot / Ronald A. Sage ... [et al.] -- Soft tissue reconstructive options for the ulcerated or gangrenous diabetic foot / Christopher E. Attinger -- Role of growth factors in the treatment of diabetic foot ulceration / David L. Steed -- Living skin equivalents for the diabetic foot ulcer / Thanh Dinh and Aristidis Veves -- Lower extremity arterial reconstruction in patients with diabetes mellitus: principles of treatment / Kakra Hughes, David Campbell and Frank B. Pomposelli, Jr. -- Angioplasty and other noninvasive surgical procedures / Sherry D. Scovell -- Psychosocial and educational implications of diabetic foot complications / Katie Weinger and Arlene Smaldone -- The role of footwear in the prevention of diabetic foot problems / Luigi Uccioli.
  • 2006 Springer
    Cortes, Pedro; Mogensen, Carl Erik.
    Angiotensin II and its receptors in the pathogensis of diabetic nephropathy / David J. Leehey, Ashok K. Singh, and Rekha Singh -- Altered renal microvasculature function in early diabetes / Pamela K. Carmines, Joseph P. Bast, and Naohito Ishii -- Proteinuria and interstitial fibrogenesis in diabetic nephropathy / Raimund Hirschberg -- Podocytes and diabetic nephropathy / George Jerums, Sianna Panagiotopoulos, and Richard MacIsaac -- Altered glucose transport and its metabolic effects in glomerular cells / Charles W. Heilig -- mRNA translation in diabetic nephropathy / Balakuntalam S. Kasinath ... [et al.] -- The hexosamine biosynthesis pathway: contribution to the pathogenesis of diabetic nephropathy / I. George Fantus ... [et al.] -- Glycation: receptor for advanced glycation endproducts and diabetic nephropathy / Vivette D'Agati and Ann Marie Schmidt -- Oxidative and glycooxidative stress in diabetic nephropathy / Frederick R. DeRubertis and Patricia A. Craven -- Connective tissue growth factor in the pathogenesis of diabetic nephropathy: a target for therapeutic intervention / Bruce L. Riser, Alessia Fornoni, and Sujatha Karoor -- Vascular endothelial growth factor as a determinant of diabetic nephropathy / Geoffrey Boner and Mark E. Cooper -- Transforming growth factor-[beta] signal transduction in the pathogenesis of diabetic nephropathy: identifying molecular targets for therapeutic intervention / Sheldon Chen and Fuad N. Ziyadeh -- Hepatocyte growth factor: physiological and therapeutic ligand to attenuate diabetic nephropathy / Shinya Mizuno and Toshikazu Nakamura -- Proteomics in the investigation of diabetic nephropathy / Visith Thongboonkerd -- Gene expression profiling in the investigation of diabetic nephropathy / Katalin Susztak, Erwin Bottinger, and Kumar Sharma -- PPAR- ligands and diabetic nephropathy / Keiji Isshiki, Daisuke Koya, and Masakazu Haneda -- -Endosulfine in diabetic nephropathy / Jerry Yee and Balazs Szamosfalvi -- The prospect of a novel therapeutic, bone morphogenetic protein-7, in diabetic nephropathy / Keith A. Hruska ... [et al.] -- Genetic determinants of diabetic nephropathy in type 2 diabetes / Grzegorz Placha and Andrzej S. Krolewski -- Major risk indicators for diabetic kidney disease / Katherine R. Tuttle -- The structure of human diabetic nephropathy / Michael Mauer and Behzad Najafian -- Diabetic kidney disease in transitional and disadvantaged populations / E. Jennifer Weil and Robert G. Nelson -- Screening and treatment of early diabetic renal disease in type 1 and type 2 diabetes / Ellie Chuang and Mark E. Molitch -- Treatment in advanced renal disease in type 1 and type 2 diabetes / Eberhard Ritz and Gunter Wolf -- Diabetic and renal disease: ACE inhibitors and/or angiotensin receptor blockers: does it matter? / Carl Erik Mogensen and Niels Holmark Andersen -- Management of diabetic end-stage renal disease with dialysis / Ploumis S. Passadakis and Dimitrios G. Oreopoulos -- Diabetic retinopathy and nephropathy / Ronald Klein -- Hypertension and cardiovascular disease / Adam Whaley-Connell, Kurt Sowers, and James R. Sowers -- Endothelial dysfunction and diabetic nephropathy / Coen D.A. Stehouwer ... [et al.] -- Anemia and diabetic nephropathy / George Jerums ... [et al.].
  • 2007 Springer
    Malik, Rayaz A.; Veves, Aristidis; Veves, Aristidis.
    Historical aspects of diabetic neuropathies -- The epidemiology of diabetic neuropathy -- Genomics of diabetic neuropathy -- Transgenic and gene knockout analysis -- Hyperglycemia-initiated mechanisms in diabetic neuorpathy -- Effectors-sonic hedgehog and p38 mitogen-activated protein kinase -- Neuronal and Schwann cell death in diabetic neuropathy -- Metabolic-functional-structural correlations in somatic neuropathies in the spontaneously type 1 and type 2 diabetic BB-rats -- Experimental diabetic autonomic neuropathy -- Spinal cord: structure and function in diabetes -- Diabetic encephalopathy -- Microangiopathy, diabetes -- Pathogenesis of human diabetic neuropathy -- Clinical features of diabetic polyneuropathy -- Micro- and macrovascular disease in diabetic neuropathy -- Clinical diagnosis of diabetic neuropathy -- Punch skin biopsy in diabetic neuropathy -- Aldose reductase inhibitors for the treatment of diabetic neuropathy -- Other therapeutic agents for the treatment of diabetic neuropathy -- Pathophysiology of neuropathic pain -- Treatment of painful diabetic neuropathy -- Focal and multifocal diabetic neuropathy -- Hypoglycemia and the autonomic nervous system -- Cardiovascular autonomic neuropathy -- Postural hypotension and anhidrosis -- Gastrointestinal syndromes due to diabetes mellitus -- Genitourinary complications -- Management of diabetic foot complications.
  • 2008 Springer
    Duh, Elia J.
    1 Nonproliferative diabetic retinopathy -- 2 Proliferative diabetic retinopathy -- 3 The epidemiology of diabetic retinopathy -- 4 Diagnostic modalities in diabetic retinopathy -- 5 In vivo models of diabetic retinopathy -- 6 The polyol pathway and diabetic retinopathy -- 7 The role of advanced glycation in diabetic retinopathy -- 8 The role of protein kinase C in diabetic retinopathy -- 9 Oxidative stress in diabetic retinopathy -- 10 Pericyte loss in the diabetic retina -- 11 Capillary dropout in diabetic retinopathy -- 12 Neuroglial dysfunction in the pathophysiology of diabetic retinopathy -- 13 The role of inflammation in the pathophysiology of diabetic retinopathy -- 14 Vascular permeability in diabetic retinopathy -- 15 Retinal neovascularization and the role of VEGF -- 16 Beyond VEGF: other factors important in retinal neovascularization: potential targets in proliferative diabetic retinopathy -- 17 Anti-VEGF therapy as an emerging treatment for diabetic retinopathy -- 18 Clinical trials in protein kinase C-Beta inhibition in diabetic retinopathy -- 19 The role of intravitreal steroids in the management of diabetic retinopathy -- 20 Antagonism of the growth hormone axis as a therapeutic strategy for diabetic retinopathy -- 21 Diabetic retinopathy and systemic complications.
  • 2007 Karger
    Lang, Gabriele E.
    Pathophysiology of diabetic macular edema / A.M. Joussen, N. Smyth, C. Niessen -- Characterization and relevance of different diabetic retinopathy phenotypes / J. Cunha-Vaz -- Optical coherence tomography findings in diabetic retinopathy / G.E. Lang -- Laser treatment of diabetic retinopathy / G.E. Lang -- Benefits and limitations in vitreoretinal surgery for proliferative diabetic retinopathy and macular edema / A.M. Joussen, S. Joeres, B. Kirchhof -- Diffuse diabetic macular edema: pathology and implications for surgery / A. Gandorfer -- Intravitreal triamcinolone acetonide for diabetic retinopathy / J.B. Jonas -- Use of long-acting somatostatin analogue treatment in diabetic retinopathy / B.O. Boehm -- Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (Macugenr) in diabetic retinopathy / C. Starita ... [et al.] -- Pharmacologic vitreolysis / A. Gandorfer -- Treatment of diabetic retinopathy with protein kinase C subtype [alpha] inhibitor / G.E. Lang.
    Also available: Print – 2007
  • 2010 Springer
    Browning, David J.
  • 2010
    Wu, Gloria.
    PrintStatus: Not Checked OutLane Catalog Record
    Epidemiology -- Pathophysiology of diabetes -- National clinical trials and classification -- Diagnostic testing -- Examination of the diabetic patient -- New treatment modalities -- Management of nonproliferative diabetic retinopathy -- Management of clinically significant macular edema or diabetic macular edema -- Management of proliferative diabetic retinopathy -- Indications for vitrectomy -- Diabetes in pregnancy -- Complications -- Diabetes and glaucoma -- Informed consent -- Guidelines for nursing staff and medical assistants.
  • 2005 Karger
    Desoye, Gernot; Djelmiš, J.; Ivanisević, M.
    Epidemiology of pregestational and gestational diabetes / I. Pavliʹc-Renar, Z̆. Metelko -- Fuel-mediated 'functional teratogenesis' and primary prevention / A. Plagemann -- Endocrine changes in diabetic pregnancy / A. Kautzky-Willer, D. Bancher-Todesca -- Metabolic changes in diabetic pregnancy / E. Herrera -- Leptin in the diabetic pregnancy / S. Hauguet-De Mouzon, J. Lepercq, P. Catalano -- Maternal diabetes and embryonic development / R. De Hertogh -- Normal and abnormal fetal growth / I. Cetin, T. Radaelli -- Effect of nutrition on fetal development: a view on the pancreatic [beta]-cells / B. Blondeau, B. Breant -- The human placenta in diabetes / G. Desoye, P. Kaufmann -- Vasculogenesis and angiogenesis in the diabetic placenta / L. Leach, T.M. Mayhew -- Morphological findings in infants and placentas of diabetic mothers / M. Kos, M. Vogel -- Principles of evidence-based medicine: the lesson for diabetic pregnancy / T.R. Pieber -- The Graz approach to diabetes in pregnancy / P.A.M. Weiss, G. Desoye -- Clinical management of pregnancies complicated with type 1/type 2 diabetes mellitus / J. Djelmis̆ -- Nutritional management of diabetes in pregnancy / A. Dornhorst, G. Frost -- Diabetes-related antibodies and pregnancy / R. Corcoy, D. Mauricio, A. De Leiva -- Insulin and oral hypoglycemic agents in pregnancy / Z̆. Metelko, I. Pavliʹc-Renar -- Continuous glucose monitoring for the evaluation and improved treatment adjustment in gravid women with diabetic pregnancy / M. Hod, Y. Yogev -- Fetal hypoxia and its monitoring in pregestational diabetic pregnancies / K.A. Teramo, V.K. Hiilesmaa -- Ultrasonic surveillance of the diabetic fetus / M. Ivanis̆eviʹc -- Diabetic pregnancy: maternal metabolic and microvascular issues in type 1 diabetes mellitus / D.W.M. Pearson -- Pre-eclampsia in women with type 1 diabetes / E.R. Mathiesen and P. Damm -- Management of delivery / V.A. Miller, M.D.G. Gillmer -- Offspring of diabetic pregnancy / B. Persson, U.J. Eriksson, U. Hanson -- Long-term consequences of gestational diabetes mellitus / J. Lauenborg, E.R. Mathiesen, P. Damm.
  • 2013
    Mackowiak, Philip A.
    Mackowiak traces the history of medicine through the illnesses of some of the most influential figures of the past. The diseases suffered by these figures had profound effects on their lives and their legacies.
  • 2015 Springer
    Moreira, Andre Luis; Saqi, Anjali.
    This volume provides a practical yet comprehensive guide to manage the shift in the diagnosis of lung cancer from large resections to small samples, including cytology specimens and core biopsies. Specifically, it outlines various available minimally-invasive modalities and presents algorithms to optimize and maximize sample collection and processing beginning at the time of tissue acquisition during the procedure. Secondly, the book provides an overview of the various existing and emerging lung cancer therapies and why a specific diagnosis is crucial. Key elements for the classification of small biopsies and cytology proposed by the ATS, IASLC, and ERS are highlighted. A section dedicated to immunohistochemistry offers a logical, step-by-step guide to sub-classify lung cancers and to differentiate them from metastases. The text also provides a review of the various molecular tests (and alternatives in cases of scant tissue) required for lung adenocarcinomas. Finally, potential pitfalls to avoid during acquisition, processing, and classification are discussed. With contributions from a team of multidisciplinary authors who are regularly involved in the care of lung cancer patients , Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology is an invaluable reference guide for pathologists, pathologists-in-training, and allied professionals, including oncologists, pulmonologists, surgeons, and radiologists.
  • 2011 ClinicalKey
    Daubeney, Piers E. F.; Gatzoulis, Michael A.; Webb, Gary D.
    A practical, one-stop resource designed to help you manage the unique challenges of treating long-term adult survivors of congenital heart disease. Authored by internationally known leaders in the field, this edition is the first that truly integrates anatomy and imaging technology into clinical practice, and includes new chapters on cardiac CT for ACHD assessment, critical and perioperative care, anesthesia for ACHD surgery, cardiac resynchronization therapy, and transition of care. Congenital defects are presented with high-quality illustrations and appropriate imaging modalities. See imaging findings as they appear in practice and discern subtle nuances thanks to new, high-quality images and illustrations.
  • NGC
  • 2001 NLM
    Glock, Martha; Canto, Maria T.; Horowitz, Alice M.
    Citations include changes during past decades in the prevalence, distribution, and progression of dental caries have implications for diagnosis, treatment, prediction of risk, and prevention in individuals or populations. Traditional approaches for treating carious lesions in a surgical manner are being replaced by newer strategies that emphasize disease prevention and conservation. Citations for this bibliography were gathered from journal articles and conference papers written primarily in English and including both human and animal studies.
  • 2015 Springer
    Aaron, Roy K.
    Health Care Organization and its Impact on Care of Diseases of the Hip -- Prevalence and Societal Burden of Hip Osteoarthritis -- Metabolic Syndrome, Obesity, and Osteoarthritis -- Biomechanical Considerations in Arthritis of the Hip -- Gait Pathomechanics in Hip Disease -- Femoroacetabular Impingement -- Osteonecrosis -- Osteoporosis and Hip Fractures -- Preoperative Management of Paget's Disease -- Metabolic Bone Disease Following Organ Transplantation -- Options for Primary Hip Arthroplasty -- Hip Sepsis and the Prevention of Perioperative Infections -- Venous Thromboembolism in Total Hip Arthroplasty.
  • 2008 Springer
    Biller, Beverly M. K.; Swearingen, Brooke.
  • 2009 Springer
    Diamanti-Kandarakis, Evanthia; Farid, Nadir R.
    Part I. The syndrome. 1. Clinical manifestations of PCOS / Pasquali Renato --2. The Menstrual cycle in PCOS / Sabrina Gill and Janet E. Hall -- 3. The Radiology of Polycystic ovaries / Susan J. Barter -- Part II. Origins -- 4. Insulin resistance in PCOS / Evanthia Diamanti-Kandarakis and Charikleia D. Christakou -- 5. Genetics of metabolic syndrome and genetic lipodystrophies / Tisha R. Joy and Robert A. Hegele -- 6. The Genetics of polycystic ovary syndrome / Brad Eilerman, Marzieh Salehi, and Yaron Tomer -- 7. Uterine origins and evolution in childhood / Agathocles Tsatsoulis and Nectaria Xita -- Part III. Consequences -- 8. Hyperandrogenism in PCOS / Neoklis A. Georgopoulos, Eleni Kandaraki, and Dimitrios Panidis -- 9. The Risk of diabetes and metabolic syndrome in PCOS / Thomas M. Barber -- 10. The Risks of cardiovascular disease and diabetes in the Polycystic ovary syndrome / Susmeeta T. Sharma and John E. Nestler -- 11. Pregnancy complications in PCOS / Roy Homburg -- 12. Polycystic ovary syndrome, sleep apnea, and daytime sleepiness and fatigue / Alexandros N. Vgontzas and Susan Calhoun -- 13. Polycystic ovarian syndrome and gynaecological cancer / Alexandra Lawrence and W. Peter Mason -- 14. PCOS, depression, and Alzheimer's disease / Pascale G. Stemmle, Heather A. Kenna, and Natalie L. Rasgon -- 15. Psychological issues and their treatment / Melissa J. Himelein and Samuel S. Thatcher -- Part IV. Management -- 16. Dietary management of PCOS / Kate Marsh -- 17. Exercise in the treatment of PCOS / Emma Stevenson -- 18. Medical treatment / Jean-Patrice Baillargeon and Nadir R. Farid -- 19. Therapy of hirsutism / Salvatore Benvenga -- 20. Ovulation induction in PCOS / Evert J.P. van Santbrink -- 21. IVF in Polycystic ovary syndrome / Rehan Salim and Paul Serhal -- 22. The Surgical management of Polycystic ovarian syndrome / Colin J. Davis -- 23. When periods stop: long-term consequences of PCOS / Enrico Carmina, Ettore Guastella, and Manfredi Rizzo.
  • 2015 Springer
    Frantz, Robert P.; Klinger, James R.
    The Pulmonary Circulation -- Epidemiology and Disease Classification of Pulmonary Hypertension -- Pathogenesis of Pulmonary Arterial Hypertension -- Hypoxic Pulmonary Hypertension -- Pulmonary Hypertension In Chronic Heart And Lung Disease -- Chronic Thromboembolic Pulmonary Hypertension -- Schistosomiasis- Associated Pulmonary Arterial Hypertension -- Approach to the Patient with Elevated Pulmonary Arterial Pressure -- Echocardiography -- Pulmonary Hemodynamics and Right Heart Catheterization -- Cardiopulmonary Exercise Testing in Pulmonary Hypertension -- Adjunct Therapy and Calcium Channel Blockers -- Prostacyclin Therapy for Pulmonary Arterial Hypertension -- Endothelin Receptor Antagonists.-Modulation Of cGMP Synthesis And Metabolism -- Combination Therapy for the Treatment of Pulmonary Arterial Hypertension -- Investigative Therapies in Pulmonary Arterial Hypertension -- Pulmonary Hypertension In Critically Ill Patients -- Perioperative Management of Pulmonary Hypertension.
  • 2015 Springer
    Krege, Susanne.
    This book presents the views of leading European experts on the diagnosis and management of testicular cancer, with coverage of current hot topics in the field. It opens by providing an overview of the recommendations in the most recent consensus paper from the European Germ Cell Cancer Consensus Group, which is based on interdisciplinary cooperation among urologists, medical oncologists, radio-oncologists, pathologists, and basic scientists. The remainder of the book focuses on areas of controversy in the diagnosis, treatment, and follow-up of testicular cancer. In each case the evidence base is discussed and results from the most recent studies are reviewed, drawing attention to new findings that might alter treatment recommendations. The treatment-related chapters cover a broad range of issues, including the best approach in patients with poor-prognosis and recurrent disease and those with long-term toxicities. Relevant aspects of survivorship care are also addressed. The book will help clinicians and practitioners to achieve the goals of minimizing therapy and its side-effects without reducing efficacy in low stage disease, improving the cure rate in advanced disease, and enhancing follow-up and long-term survivorship.
  • 2015 Springer
    Hospenthal, Duane R.; Rinaldi, Michael G.
    Part One Approach to Patients -- Chapter 1 Approach to Patients with Suspected Fungal Infections -- Part Two Laboratory and Radiological Diagnosis -- Chapter 2 Basic Mycology -- Chapter 3 Diagnostic Molecular Biology -- Chapter 4 Diagnostic Histopathology -- Chapter 5 Diagnostic Immunology -- Chapter 6 Diagnostic Radiology -- Part Three Antifungal Agents -- Chapter 7 Antifungal Agents -- Part Four Mycoses -- Chapter 8 Candidiasis -- Chapter 9 Infection Due to non-Candidal Yeasts -- Chapter 10 Aspergillosis -- Chapter 11 Hyalohyphomycosis -- Infection Due to Hyaline Moulds -- Chapter 12 Phaeohyphomycosis -- Infection Due to Dark (Dematiaceous) Moulds -- Chapter 13 Mucormycosis (Zygomycosis) -- Chapter 14 Pneumocystosis -- Chapter 15 Cryptococcosis -- Chapter 16 Blastomycosis -- Chapter 17 Coccidioidomycosis -- Chapter 18 Histoplasmosis -- Chapter 19 Paracoccidioidomycosis -- Chapter 20 Sporotrichosis -- Chapter 21 Dermatophytosis (Tinea) and Other Superficial Fungal Infections -- Chapter 22 Fungal Infections of Implantation (Chromoblastomycosis, Mycetoma, Entomophthoramycosis and Lacaziosis) -- Part Five Instructive Cases. Instructive Cases -- Instructive Cases Discussion.
  • 2016 Springer
    Vaezi, Michael F.
  • 2007 Springer
    Hospenthal, Duane R.; Rinaldi, Michael G.
    Part I. Approach to patients. Approach to patients with suspected fungal infections / Clinton K. Murray and Duane R. Hospenthal -- Part II. Laboratory and radiological diagnosis. Basic mycology / Deanna A. Sutton -- Diagnostic histopathology / Michael B. Smith and Michael R. McGinnis -- Diagnostic immunology / Samit S. Desai and Brian Wong -- Diagnostic radiology / Maria Angela C. Hospenthal and Constanza J. Gutierrez -- Part III. Antifungal agents. Antifungal agents / Russel E. Lewis and Annette W. Fothergill -- Part IV. Mycoses. Cadidiasis / Jack D. Sobel -- Infection due to non-candidal yeasts /Jose A. Vazquez -- Aspergillosis / Helen W. Boucher and Thomas F. Patterson -- Hyalophomycosis infection due to hyaline moulds / Rhonda V. Fleming and Elias J. Anaissie -- Phaeohyphomycosis infection due to dark (dematiaceous) moulds / Sanjay G. Revankar -- Zygomycosis (mucormycosis) / Charalampos Antachopoulos, Juan C. Gea-Banacloche, and Thomas J. Walsh -- Pneumocystosis / Francis Gigliotti and Terry W. Wright -- Cryptococcosis / Mathee Chayakulkeeree and John R. Perfect -- Blastomycosis / Stanley W. Champan and Donna C. Sullivan -- Coccidioidomycosis / Royce H. Johnson and Chehla Baqi -- Histoplasmosis / L. Joseph Wheat and Nicholas G. Conger -- Paraccocidiodoycosis / Angela Restrepo, Angela M. Tobón, and Carlos A. Agudelo -- Sporotrichosis / Carol A. Kauffman -- Dermatophytosis (tinea) and other superficial fungal infections / Aditya K. Gupta and Elizabeth A. Cooper -- Subcutaneous fungal infections (chromoblastomycossi, mycetoma, and lobomycosis) / Michael B. Smith and Michael R. McGinnis
  • 2008 NGC
  • 2009 Springer
    Önerci, Metin.
  • 2012 ClinicalKey
    Kapural, Leonardo; Kim, Philip.
    Epidemiology and Etiology of Discogenic Pain: How Big Is the Problem? -- Establishing the Diagnosis of Discogenic Back Pain: An Evidence-Based Algorithmic Approach -- Imaging for Discogenic Pain -- Provocation Discography -- Analgesic Discography -- Discogenic Pain: Intradiscal Therapeutic Injections and Use of Intradiscal Biologic Agents -- Radiofrequency and Other Heat Applications for the Treatment of Discogenic Pain -- Arthrodesis and Fusion for the Treatment of Discogenic Neck and Back Pain: Evidence-Based Effectiveness and Controversies -- Nucleus Pulposus Replacement and Motion-Sparing Technologies -- Cervical and Thoracic Discogenic Pain: Therapeutic Nonsurgical Options -- Disc Herniations: Injections and Minimally Invasive Techniques -- Current Surgical Options for Intervertebral Disc Herniation in the Cervical and Lumbar Spine -- Neuromodulation and Intrathecal Therapies for the Treatment of Chronic Radiculopathy Related to Intractable Discogenic Pain.
  • 2007 Springer
    Kligman, Albert M.; Norman, Robert A.
  • 2010 Thieme Book
    Barth, Volker.
    "A practical approach to the early detection and management of breast cancer. This lavishly illustrated atlas provides radiologists with essential information for the differential diagnosis of breast diseases on the basis of clinical presentation, mammography, and ultrasound. The book begins with chapters on tumor biology, prognostic factors, and histology. The authors then provide a thorough evaluation of various methods for early detection and accurate diagnosis, including analog and digital mammography, ultrasound, MR imaging, PET/CT, and interventional procedures. They discuss in detail the strengths and limitations of each imaging modality, aspects of quality control, test intervals, peri- and postoperative management principles, and follow-up care.Highlights:- Presentation of difficult cases that effectively demonstrate the diagnostic hurdles and forensic pitfalls in breast diagnosis- Special sections on breast cancer in men and young women, with discussion of women who are pregnant or lactating- Color-coded practical tips and clinical notes for optimal comprehension of the material- Extensive Q&A sections for self-testing in two major chapters - More than 1,700 high-quality illustrations, including clinical color photographs, ultrasound images, and mammograms"--Provided by publisher.
  • 2005 Springer
    Mazur, Michael T.; Kurman, Robert J.
    Also available: Print – 2005
  • 2015 Springer
    Fraig, Mostafa M.
    Small Sample Lung Biopsy Techniques in the Diagnosis of Airway and Parenchymal Lung Diseases -- Principles of Imagining Lung Disease -- Types of Biopsies -- Air Space Occupying Diseases -- Interstitial Lung Diseases in Small Lung Biopsies -- Diagnosis of Granulomatous Disease and Vasculitis in Small Lung Biopsies -- Benign Tumors of the Lung in Small Lung Biopsies -- Malignant Tumors of the Lung in Small Lung Biopsies.
  • 2005 HighWire
    Fernández-Avilés, Francisco.
    Also available: Print – 2005
  • 2013 Springer
    Turmel-Rodrigues, Luc; Beyssen, Bernard; Godier, Jean-Jacques; Mouton, Albert; Pengloan, Josette; Renaud, Claude J.; Shoenfeld, Richard.
    Endovascular repair of dialysis fistulas and grafts: strengths and weaknesses -- Role of the nephrologist, interventional radiologist, and vascular access in the treatment of end-Stage renal disease -- Access creation strategy -- Natural history of vascular access -- Radiological anatomy and preoperative imaging of upper limb vessels -- Indications and imaging modalities in dialysis access -- Psychological and clinical issues -- Patient preparation prior to angiography and endovascular interventions -- Angiography (Fistulography) -- Dilation and stent placement -- Hand ischemia -- Treatment of thrombosed accesses -- Therapeutic occlusion of dysfunctional accesses -- Complications during and after vascular access endovascular procedures -- Vascular access intervention outcomes.
  • 1994 PsychiatryOnline
    Also available: Print – 1994
  • 2013 PsychiatryOnline
    Section 1. DSM-5 basics. Introduction -- Use of the manual -- Cautionary statement for forensic use of DSM-5 -- Section 2. Diagnostic criteria and codes. Neurodevelopmental disorders -- Schizophrenia spectrum and other psychotic disorders -- Bipolar and related disorders -- Depressive disorders -- Anxiety disorders -- Obsessive-compulsive and related disorders -- Dissociative disorders -- Somatic symptom and related disorders -- Feeding and eating disorders -- Elimination disorders -- Sleep-wake disorders -- Sexual dysfunctions -- Gender dysphoria -- Disruptive, impulse-control, and conduct disorders -- Substance-related and addictive disorders -- Neurocognitive disorders -- Personality disorders -- Paraphilic disorders -- Other mental disorders -- Medication-induced movement disorders and other adverse effect of medication -- Other conditions that may be a focus of clinical attention -- Section 3. Emerging measures and models. Assessment measures -- Cultural formulation -- Alternative DSM-5 Model for Personality Disorders -- Conditions for further study -- Appendix. Highlights of changes from DSM-IV to DSM-5 -- Glossary of technical terms -- Alphabetic listing of DSM-5 diagnoses and codes (ICD-9-CM and ICD-10-CM) -- Numerical listing of DSM-5 diagnoses and codes (ICD-9-CM) -- Numerical listing of DSM-5 diagnoses and codes (ICD-10-CM) -- DSM-5 advisors and other contributors.
    Also available: Print – 2013
  • 2000 PsychiatryOnline
    Also available: Print – 2000
  • 1987 PsychiatryOnline
    Also available: Print – 1987
  • c2006
    Abbott, Gerald F.; Federle, Michael P.; Rosado-de-Christenson, Melissa L.; Woodward, Paula.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006
    Abbott, Gerald F.; Federle, Michael P.; Rosado-de-Christenson, Melissa L.; Woodward, Paula.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 ClinicalKey
    Chandrasoma, Para.
    Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux. This atlas is a source of easily digestible practical information for pathologists faced with biopsies from this region. It is also aimed at gastroenterologists as they biopsy these patients.
  • 2009 ClinicalKey
    McKee, Phillip H.; Calonje, Eduardo.
    Ephelides and Lentigo -- Melanocytic Nevus -- Congenital Nevus -- Spitz and Reed Nevus -- Dysplastic Nevus -- Dermal Melanocytoses -- Melanoma General -- Melanoma Variants -- Oral Mucosa Pigmented Lesions -- Conjunctival Melanocytic Lesions.
  • 2012 ClinicalKey
    Fogo, Agnes B.; Kashgarian, Michael.
    This 2nd edition by Agnes B. Fogo, MD and Michael Kashgarian, MD, delivers practical, highly visual guidance for effectively and accurately diagnosing a wide range of pathologic entities. More than 700 high-quality illustrations help you to recognize the pathologic features and clinical manifestations of both common and rare renal disorders and to formulate confident and accurate diagnoses. Thoroughly updated throughout, this companion to Brenner & Rector's, The Kidney, 9th Edition provides the newest information regarding categorizing and classification of diseases and describes how this relates to the various morphological lesions illustrated and their clinical significance.
  • 2006 Springer Protocols
    O'Connor, Louise.
  • 2014 Thieme Book
    Heywang-Köbrunner, Sylvia H.
    "Encompassing the entire spectrum of breast imaging and diagnostics, this acclaimed text provides a systematic and pragmatic guide for all clinicians involved in diagnosing breast disease. The new third edition has been fully updated to include advances in mammography, ultrasound, breast MRI, percutaneous interventions, and emerging technologies, with pros and cons and evidence-based approaches throughout. Special features of the third edition: Coverage of the field, with comprehensive sections on examination procedures and technical requirements; histologic, clinical, and radiologic appearance of a wide range of breast pathologies; results of international screening studies; and much more. Nearly 1,200 clear radiographic images showing normal findings, benign and malignant disorders, and post-traumatic, post-surgical, and post-therapeutic changes to the breast. Innovations in digital mammography, tomosynthesis, and computer assisted detection (CAD); new chapters on imaging of implants, lesions of uncertain malignant potential, developing technologies; and more. A systematic, highly reproducible methodology for detection, diagnosis, and assessment of findings. Easy-to-follow flowcharts for the diagnostic work-up of both typical and atypical cases. Written by world-renowned authorities with decades of clinical experience, this book provides a brilliant orientation to the multimodality diagnostic approach and therapeutic significance of breast imaging findings. It is an essential reference and board review for radiologists, residents and fellows, gynecologists, oncologists, surgeons, technologists, and any other interdisciplinary specialist working to improve outcomes in breast disease"--Provided by publisher.
  • 2006 Springer
    Lerner, Alan J.
    Consensus, disagreement, and diagnostic labels -- Cerebrovascular diseases -- Dementias and behavioral disorders -- Demyelinating disorders -- Disorders of consciousness and brain death -- Epilepsy -- Genetic syndromes -- Headache -- Immune-based disorders -- Infectious diseases -- Movement disorders -- Neuromuscular disorders -- Pain, fatigue, and trauma -- Sleep disorders.
  • 2015 Springer
    Khalbuss, Walid E.
    Diagnostic Cytopathology Board Review and Self-Assessment provides a comprehensive systems-based review of non-gynecological cytology including cytomorphology, pitfalls and ancillary studies, presented in a high-yield format with board-type multiple choice questions and detailed answers. It provides an excellent review, resource, and self-assessment for pathologists, cytopathologists, and cytotechnologists, as well as trainees (pathology residents, cytopathology fellows, and cytotechology students) who are preparing for board examinations or in-service examinations, in addition to those who are looking to fine-tune their cytology diagnostic skills. The volume is organized in a systems-based format including chapters covering lung, lymph nodes, pancreas, liver, gastrointestinal tract, thyroid, salivary gland, central nervous system, soft tissue and bone, kidney, adrenal, retroperitoneal, and exfoliative cytology of urine, serous fluids, and CSF. This book is enriched with high yield review, board exam-type questions, and high quality full-color images to maximize studying and review of cytopathology.
  • 2013 ClinicalKey
    Gray, W.; Kardum-Skelin, Ika; Kocjan, Gabrijela; Levine, Tanya; Vielh, Philippe.
    Introduction -- Female genital tract -- Respiratory -- Serous effusions -- Urine cytology -- Thyroid gland -- Haemopoietic -- Breast -- Salivary gland -- Liver, biliary tree and pancreas -- Childhood tumours -- Miscellaneous -- Techniques -- Self-assessment questions.
  • 2010 ClinicalKey
    Gray, W.; Kocjan, Gabrijela.
    Cytopathology: the history, the present and the future direction -- Respiratory system -- Respiratory tract -- Serous cavities -- Serous effusions -- Breast -- Alimentary system -- Salivary glands -- Oral cavity -- Oesophagus and gastrointestinal tract -- Hepatobiliary system and pancreas -- Liver -- Gall bladder and extrahepatic bile ducts -- Pancreas -- Kidney and urinary tract -- Kidney and retroperitoneal tissues -- Urine cytology -- Lymphoreticular system -- Lymph nodes -- Other lymphoreticular organs -- Transplantation and immunosuppression -- Organ transplantation -- Immunosuppression -- Endocrine system -- Thyroid gland -- Other endocrine organs -- Male genital tract -- Prostate gland -- Testis and scrotum: cytology of testicular and scrotal masses and male infertility -- Female genital tract -- Vulva, vagina and cervix: normal cytology, hormonal and inflammatory conditions -- Cervical screening programmes -- Cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix -- Glandular neoplasms of the cervix -- Other tumours and lesions of cervix, vulva and vagina -- Cytology of the body of the uterus -- Ovaries, fallopian tubes and associated lesions -- Skin, soft tissues and musculoskeletal system -- Skin -- Soft tissue and musculoskeletal system -- Synovial fluid -- Central nervous system -- Brain and cerebrospinal fluid -- Eyelids, orbit and eye -- Childhood tumours -- New techniques.
  • 2014 CRCnetBASE
    Zeng, Haishan.
    Section 1. Basics of endoscopy and light-tissue interactions -- section 2. Endoscopic field imaging modalities -- section 3. Endoscopic point spectroscopy -- section 4. Endoscopic "point" microscopy -- section 5. Clinical applications.
  • 2014 Springer
    Gottlieb, Klaus; Marino, Gustavo.
    The available textbooks on endoscopic ultrasound (EUS) typically focus on technique and interpretation of commonly observed images and scenarios and are aimed primarily at trainees. However, independent practitioners of EUS are often challenged by unusual cases which they are expected to handle competently despite the absence of authoritative guidance. The Diagnostic Endosonography aims to fill this gap by presenting carefully selected cases that will expand the practitioner's knowledge base and cover important clinical challenges. The case material is organized principally according to anatomic site. Approximately 170 case reports are included, each of which is accompanied by an average of three to five high-quality EUS images; in addition, CT and PET scans are shown when appropriate. For each case, the case description is followed by helpful 'teaching points' as well as up-to-date literature references and suggestions for future research.
  • 2011 ClinicalKey
    Crum, Christopher P.; Lee, Kenneth R.; Nucci, Marisa R.
    Drs. Christopher P. Crum, Marisa R. Nucci, and Kenneth R. Lee help you diagnose neoplastic and non-neoplastic lesions of the female reproductive tract with their comprehensive updated. This 2nd Edition provides all of the latest guidance needed to accurately evaluate pathologic features and morphologic patterns. With 650+ new color images, an appendix with algorithms for the use of biomarkers, key points, diagnostic pearls, and more. View more than 2,250 full-color photographs and photomicrographs, ideal for side-by-side comparison to the specimens seen in the laboratory. A strong revision to cover the latest updates in the field for one of the only comprehensive references for the practicing pathologist that covers both neoplastic and non-neoplastic disorders of the female genital system.
  • 2013 ClinicalKey
    Fletcher, Christopher D. M.
    Vol. I: Introduction -- Tumors of the heart and pericardium -- Vascular tumors -- Tumors of the upper respiratory tract -- pt. A: Nasal cavity, paranasal sinuses, and nasopharynx -- pt. B: Larynx, hypopharynx, and trachea -- Tumors of the lung and pleura -- Tumors of the oral cavity -- Tumors of the salivary glands -- Tumors of the esophagus and stomach -- Tumors of the small and large intestines, including anal canal -- Tumors of the liver, biliary tree, and gallbladder -- Tumors of the exocrine pancreas -- Tumors of the urinary tract -- pt. A: Tumors of the kidney -- pt. B: Tumors of the renal pelvis and ureter -- pt. C: Tumors of the urinary bladder and urethra -- Tumors of the female genital tract -- pt. A: Ovary, fallopian tube, and broad and round ligaments -- pt. B: Endometrial tumors -- pt. C: Tumors of the placenta and gestational trophoblastic disease -- pt. D: Myometrium -- pt. E: Cervix -- pt. F: Vagina -- pt. G: Vulva -- Tumors and tumor-like conditions of the male genital tract -- pt. A: Prostate and seminal vesicles -- pt. B: Testicular neoplasms -- pt. C: Penis and scrotum -- Tumors of the peritoneum -- Vol. II: Tumors of the breast -- Tumors of the pituitary gland -- Tumors of the thyroid and parathyroid glands -- pt. A: The thyroid gland -- pt. B: The parathyroid gland -- Tumors of the adrenal gland -- Tumors of the endocrine pancreas -- Tumors of the lymphoreticular system, including spleen and thymus -- pt. A: The lymph node -- pt. B: The spleen -- pt. C: The thymus -- Tumors of the hematopoietic system -- Tumors of the skin -- Tumors of soft tissue -- Tumors of the osteoarticular system -- Tumors of the central nervous system -- Peripheral neuroectodermal tumors -- Tumors of the autonomic nervous system, including paraganglia -- Tumors of the eye and ocular adnexae -- Tumors of the ear -- Molecular genetic techniques in diagnosis and prognosis
  • v. 1-22007., 2007
    Fletcher, Christopher D. M.
    PrintStatus: Not Checked OutLane Catalog Record
    Volume 1: Introduction -- Tumors of the heart and pericardium -- Vascular tumors -- Tumors of the upper respiratory tract -- Tumors of the lung and pleura -- Tumors of the oral cavity -- Salivary gland tumors -- Tumors of the esophagus and stomach -- Tumors of the small and large intestines (including the anal region) -- Tumors of the liver, gallbladder and biliary tree -- Tumors of the exocrine pancreas -- Tumors of the urinary tract -- Tumors of the female genital tract -- Tumors of the male genital tract -- Tumors of the peritoneum -- Tumors of the breast. Volume 2: Tumors of the pituitary gland -- Tumors of the thyroid and parathyroid glands -- Tumors of the adrenal gland -- Tumors of the endocrine pancreas -- Tumors of the lymphoreticular system -- Tumors of the hematopoietic system -- Tumors of the skin -- Soft tissue tumors -- Tumors of the osteoarticular system -- Tumors of the central nervous system -- Peripheral neuroectodermal tumors -- Tumors of the autonomic nervous system (inlcuding paraganglia) -- Tumors of the eye and ocular adnexa -- Tumors of the ear -- Electron microscopy in tumor diagnosis -- Molecular genetic techniques in diagnosis and prognosis.
  • 2009
    Barkovich, A. James; Osborn, Anne G.; Salzman, Karen L.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007
    Jeffrey, R. Brooke.
  • 2011 ScienceDirect
    2011 ClinicalKey
    Broder, Joshua.
    Imaging the head and brain / Joshua Broder and Robert Preston -- Imaging the face / Joshua Broder -- Imaging the cervical, thoracic, and lumbar spine / Joshua Broder -- Imaging soft tissues of the neck / Joshua Broder -- Imaging the chest : the chest radiograph / Joshua Broder -- Imaging chest trauma / Joshua S. Broder -- Imaging of pulmonary embolism and nontraumatic aortic pathology / Joshua Broder -- Cardiac CT imaging / Joshua Broder -- Imaging of nontraumatic abdominal conditions / Joshua Broder -- Imaging abdominal and flank trauma / Joshua Broder -- Imaging abdominal vascular catastrophes /Joshua Broder -- Imaging the genitourinary tract / Joshua Broder -- Imaging of the pelvis and hip / Joshua Broder -- Imaging the extremities / Joshua Broder -- Emergency department applications of musculoskeletal magnetic resonance imaging : an evidence-based assessment / Joshua Broder -- "Therapeutic imaging" : image-guided therapies in emergency medicine / Joshua Broder.
  • 2010 Springer
    Bonakdar-Pour, Akbar; Khurana, Jasvir S.; Reinus, William R.
    Bone Structure and Function / Fayez F. Safadi and Jasvir S. Khurana -- Systematic Approach to Metabolic Diseases of Bone / Akbar Bonakdarpour -- Systematic Approach to Radiology of Endocrine Disorders Affecting the Musculoskeletal System / Akbar Bonakdarpour and Colleen Veloski -- Circulatory Diseases of Bone and Adjacent Soft Tissues / Wilfred C.G. Peh and Seoung-Oh Yang -- Imaging Approach to Musculoskeletal Trauma / William R. Reinus -- Imaging and Understanding Fracture Fixation / Bahman Rafiee -- Systematic Approach to Tumors and Focal Lesions of Bone / Shigeru Ehara and Jasvir S. Khurana -- Systematic Approach to Tumors and Tumor-Like Conditions of Soft Tissue / Theodore T. Miller, Carolyn M. Sofka, Paul Zhang and Jasvir S. Khurana -- Imaging Approach to Hemoglobinopathies / Avneesh Chhabra and William R. Reinus -- Imaging Approach to Musculoskeletal Infections / William R. Reinus -- Systematic Approach to Arthropathies / William R. Reinus -- Imaging of Prostheses / Sayed Ali and William R. Reinus -- Systematic Approach to Skeletal Dysplasias with Emphasis on Non-lethal Disorders / Akbar Bonakdarpour -- Interventional Procedures in Musculoskeletal Radiology / Jamshid Tehranzadeh, Scott Seibert and Afshin Gangi.
  • 2015 Thieme Book
    Szeimies, Ulrike.
  • 2008 Thieme Book
    Lanz, Ulrich; Schmitt, Rainer.
    With its complex anatomy and specialized biomechanics, the human hand has always presented physicians with a unique challenge when it comes to diagnosing and treating the diseases that afflict it. And while recent decades have seen a rapid increase in the number of therapeutic options, many diseases and injuries of the hand are still commonly misinterpreted. In this book, an interdisciplinary team, comprising specialists in radiology, surgery, and rheumatology, presents a comprehensive, reliable guide to this topographically intricate area. Highlights include: More than 1,000 high-quality illustrations; state-of-the-art imaging modalities -- including multiline spiral CR, with 2D displays and 3D reconstructions, and contrast -- enhanced MRI with multi-channel, phased-array coils; an overview of all currently used methods of examination; a detailed presentation of the anatomic and functional foundations necessary for diagnosis; full coverage of all disorders of the hand; and systematic treatment of each disease's definition, pathogenesis, and clinical symptoms, according to a graduated diagnostic plan.
  • 2010
    Ross, Jeffrey S.; Borg, Bryson; Crim, Julia R.; Moore, Kevin R.; Shah, Lubdha M.
    PrintStatus: Not Checked OutLane Catalog Record
    Congenital -- Scoliosis -- Vertebral column, discs, and paraspinal muscle -- Cord, dura, and vessels -- Degenerative diseases -- Spondylolisthesis and spondylolysis -- Inflammatory, crystalline, and miscellaneous arthritides -- Infections -- Inflammatory and autoimmune disorders -- Neoplasms -- Nonneoplastic cysts and tumor mimics -- Vascular and systemic disorders -- Plexus and peripheral nerve lesions -- Postoperative imaging and complications -- Hardware -- Post-radiation and chemotherapy complications.
  • 2014 ClinicalKey
    Dabbs, David J.
    Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art.
  • 2010 Springer
    Hersen, Michel; Segal, Daniel L.
    Basic issues in interviewing and the interview process / Daniel L. Segal, Andrea June, and Meghan A. Marty -- Interviewing strategies. rapport, and empathy / Catherine Miller -- Presenting problem, history of presenting problem, and social history / Philinda Smith Hutchings and Thomas B. Virden -- Mental status examination / Michael Daniel and Jessica Gurczynski -- Dealing with defense and defensiveness in interviews / Steven N. Gold and Yenys Castillo -- Consideration of neuropsychological factors in interviewing / Brian Yochim -- Anxiety disorders / Rose C. Smith ... [et al.] -- Mood disorders / Leilani Feliciano and Amber M. Gum -- Schizophrenia / Wendy N. Tenhula and Jason Peer -- Personality disorders / Brian P. O'Connor and Edouard S. St. Pierre -- Alcohol problems / David C. Hodgins, Katherine Diskin, and Jonathan N. Stea -- Drug abuse / Jessica F. Magidson, Marina A. Bornovalova, and Stacey B. Daughters -- Sexual dysfunctions and deviations / Caroline F. Pukall, Marta Meana, and Yolanda Fernandez -- Eating disorders / Risa J. Stein, Ryan D. Field, and John P. Foreyt -- Psychophysiological disorders / Ivan R. Molton and Katherine A. Raichle -- Posttraumatic stress disorder / Erin Smith and Sheila A.M. Rauch -- Marital dyads / William Fals-Stewart, Wendy K.K. Lam, and Michelle L. Kelley -- Children / Mary Ashton Phillips and Alan M. Gross -- Sexually and physically abused children / Grace S. Hubel, Mary Fran Flood, and David J. Hansen -- Older adults / Christine Gould, Barry A. Edelstein, and Caroline Ciliberti -- Interviewing inheathh psychology and medical settings / Jay M. Behel and Bruce Rybarczyk.
  • 2007
    Garcia, Lynne Shore.
    PrintStatus: Not Checked OutLane Catalog Record
    Philosophy and approach to diagnostic parasitology -- Intestinal protozoa: amebae -- Intestinal protozoa: flagellates and ciliates -- Intestinal protozoa (coccidia and microsporidia) and algae -- Free-living amebae -- Protozoa from other body sites -- Malaria and babesiosis -- Leishmaniasis -- Trypanosomiasis -- Intestinal nematodes -- Tissue nematodes -- Filarial nematodes -- Intestinal cestodes -- Tissue cestodes: larval forms -- Intestinal trematodes -- Liver and lung trematodes -- Blood trematodes: schistosomes -- Unusual parasitic infections -- Parasitic infections in the compromised host -- Nosocomial and laboratory-acquired infections -- Immunology of parasitic infections -- Antibody and antigen detection in parasitic infections -- Histologic identification of parasites -- Medically important arthropods -- Treatment of parasitic infections -- Collection, preservation, and shipment of fecal specimens -- Macroscopic and microscopic examination of fecal specimens -- Additional techniques for stool examination -- Examination of other specimens from the intestinal tract and the urogenital system -- Sputum, aspirates, and biopsy material -- Procedures for detecting blood parasites -- Parasite recovery: culture methods, animal inoculation, and xenodiagnosis -- Fixation and special preparation of fecal parasite specimens and arthropods -- Artifacts that can be confused with parasitic organisms -- Equipment, supplies, safety, and quality system recommendations for a diagnostic parasitology laboratory: factors influencing future laboratory practice -- Medical parasitology: case histories.
  • 2011 Springer
    Schrijver, Iris.
    Cystic Fibrosis -- Alport Syndrome -- Alpha Thalassemia -- Charcot-Marie-Tooth Disease -- Hearing Loss -- Polycystic Kidney Disease -- Fragile X Syndrome -- Malignant Hyperthermia -- Rh Incompatibility -- Pharmacogenetics -- B-Cell Lymphoma -- T-Cell Lymphoma -- Posttransplant Lymphoproliferative Disorder -- HIV-Associated Hodgkin Lymphoma -- Chronic Myelogenous Leukemia -- Myeloproliferative Neoplasms -- Acute Myeloid Leukemia: FLT3/NPM1 -- Acute Myeloid Leukemia: CEBPA -- Bone Marrow Engraftment Analysis -- Mixed Phenotype Acute Leukemia -- Breast Cancer -- Lung Adenocarcinoma -- Melanoma -- Thyroid Cancer -- Renal Cell Carcinoma -- Gastrointestinal Stromal Tumor -- Lynch Syndrome -- Oligodendroglioma -- Glioblastoma Multiforme -- Carcinoma of Unknown Primary -- Human Immunodeficiency Virus -- Cytomegalovirus -- Human Papillomavirus -- Chlamydia trachomatis -- MRSA -- Influenza A (H1N1) -- Bordetella pertussis -- Human Metapneumovirus -- BK Virus -- Respiratory Viruses.
  • 2007 Ovid
    Joseph, Jeffrey T.
    Smear technique -- Smear patterns -- Reactive lesions -- Infectious diseases -- Infiltrative gliomas -- Other glial tumors -- Neural and primitive tumors -- Hematological tumors -- Extra-axial tumors -- Regional tumors -- Metastatic tumors -- Miscellanea.
    Also available: Print – 2007
  • 2009 Springer
    Kornienko, V. N.; Pronin, I. N.
  • 2006 Springer
    Allen-Auerbach, M.; Schiepers, C.
    1. Introduction / Christiaan Schiepers, p. 1-4 -- Part 1. Clinical Applications -- 2. Neurochemical Imaging with Emission Tomography: Clinical Applications / Giovanni Lucignani and James Frost, p. 7-37 -- 3. Assessment of Myocardial Viability by Radionuclide Techniques / Roxana Campisi, Felix Keng and Heinrich Schelbert, p. 39-59 -- 4. Thromboembolism Imaging / Henry Royal and David Hillier, p. 61-81-- 5. Renal Imaging / François Jamar and Raffaella Barone, p. 83-100 -- 6. Skeletal Scintigraphy / Christiaan Schiepers, p. 101-111 -- 7. Imaging Infection and Inflammation / Huub Rennen, Chantal Bleeker-Rovers and Wim Oyen, p. 113-126 -- 8. Gastrointestinal Nuclear Medicine / Jean-Luc Urbain, p. 127-134 -- 9. Hepatobiliary Scintigraphy / Mark Tulchinsky, p. 135-152 -- 10. Peptide Imaging / Irene Virgolini and T. Traub-Weidinger, p. 153-184 --11. FDG-PET Imaging in Oncology / Christiaan Schiepers and Carl Hoh, p. 185-204 -- 12. PET/CT in Lung, Head and Neck Cancer / Hans Steinert, Gerhard Goerres and Gustav von Schulthess, p. 205-214 -- 13. PET/CT Imaging in Breast Cancer, Gastrointestinal Cancers, Gynecological Cancers and Lymphoma / Martin Allen-Auerbach, Johannes Czernin and Christiaan Schiepers, p. 215-225 -- 14. Pediatric Nuclear Medicine: A Coming of Age / Helen Nadel and Moira Stilwell, p. 227-244 -- Part 2. Basics of Scintigraphic Imaging -- 15. Radiopharmaceuticals: Recent Developments and Trends / Guy Bormans, Kristin Verbeke and Alfons Verbruggen, p. 247-274 -- 16. Instrumentation and Data Acquisition / Sibylle Ziegler and Magnus Dahlbom, p. 275-290 -- 17. Image Formation / Johan Nuyts and Dirk Bequé, p. 291-310 -- Part 3. Future Outlook -- 18. Imaging Gene Expression: Concepts and Future Outlook / Meike Schipper and Sanjiv Gambhir, p. 313-342 -- 19. Quo Vadis? / Christiaan Schiepers, p. 343-344.
  • 2012 Ovid
    Nosé, Vania.
  • 2016 Ovid
    Greenson, Joel K.
    "DP: Gastrointestinal, Second Edition provides quick, up-to-date information on gastrointestinal pathology, both visual and factual, to either help the pathologist arrive at the correct diagnosis or refresh his or her memory about the diagnosis itself. Instead of full prose text, we have provided a stripped-down outline format. The key facts regarding each diagnosis are then highlighted in a box for ease of use. Tables highlighting the salient immunostains &/or molecular tests useful in the differential diagnosis of lesions are provided when appropriate, and all diagnoses are illustrated with high-quality color images taken with the intent of mimicking real practice. We hope that this book is useful as a quick reference at the microscope during sign-out, whether to look up something as esoteric as microsporidia or something as common as serrated colorectal polyps. While the images in this book will never be outdated, the same cannot be said for the text (how many new antibodies have come out in the time it took you to read this page?). To help alleviate this problem, the purchaser has a license to ExpertConsult, the eBook version of Diagnostic Pathology: Gastrointestinal, Second Edition, which will undergo regular updates."--Provided by publisher.
  • 2011 Ovid
    Colvin, Robert B.
    Minimal change disease -- Focal segmental glomerulosclerosis -- Membranous glomerulonephritis -- Membranoproliferative glomerulonephritis and complement-related diseases -- Glomerulonephritis of infection -- IgA-related glomerulonephritis -- SLE and related autoantibody-mediated GN -- Anti-GBM nephritis -- Monoclonal immunoglobulin diseases -- Idiopathic fibrillary glomerulopathies -- Diabetic renal disease -- Inherited diseases of the glomerulus -- ANCA disease -- Vasculitis non-ANCA -- Thrombotic microangiopathies -- Diseases affecting the endothelium -- Hypertensive renal disease -- thrombotic and embolic disease -- Ischemic injury -- drug-induced tubulointerstitial diseases -- Toxins -- Immunologic tubular disease -- Genetic and metabolic diseases affecting tubules -- Bacterial infections of the kidney -- Fungal, rickettsial, and parasitic infections of the kidney -- Viral infections of the kidney -- Disease of development -- Cystic diseases -- Obstruction, reflux, and stones -- Introduction -- Rejection -- Recurrent and de novo diseases -- Nonimmunologic injury -- Stable and accepted grafts.
  • 2010 ClinicalKey
    Kradin, Richard L.
    "Online and print, this comprehensive, organ-based reference is an invaluable tool for the accurate diagnosis of infectious diseases - from the common to the most challenging." "Integrates the latest techniques in immunohistochemistry and molecular genetics throughout the text for comprehensive information on all investigative contexts relevant to ensuring diagnostic accuracy; Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection; Provides a complete visual guide to suspect lesions through superb, high-quality, full-color illustrations of key aspects of various diseases that facilitate the rapid identification of biopsy specimen; Features tables that list differential diagnosis for each lesion for quick summaries of key points in problem areas; and Highlights morphological characteristics and landmarks of tissue samples throughout the text for easy access to information necessary for signing out specimens."--BOOK JACKET.
  • 2011 Springer
    Soslow, Robert A.; Tornos, Carmen S.
    Morphologic Patterns -- Common Diagnostic Discrepancies -- Frozen Section of Ovarian Lesions -- Surface Epithelial Tumors: Pathology Introduction -- Surface Epithelial Tumors: Clinical Introduction -- Pathology of Serous Tumors -- Pathology of Endometrioid Tumors -- Pathology of Clear Cell Tumors -- Pathology of Mucinous Tumors -- Uncommon Epithelial Ovarian Tumors -- Metastatic Tumors -- Germ Cell and Sex Cord Stromal Tumors: Clinical Introduction -- Pathology of Germ Cell Tumors -- Sex Cord Stromal Tumors of the Ovary -- Pathology of Mesenchymal and Hematopoietic Tumors -- Tumors of Uncertain Histogenesis -- Fallopian Tube and Peritoneum -- Familial Cancer and Prophylactic Surgery -- Peritoneal Cytology.
  • 2013 Springer
    Moran, Cesar; Weissferdt, Annikka.
    Diagnostic Imaging of Lung and Pleural Tumors -- The Staging of Lung Cancer -- Non-Small Cell Carcinomas -- Neuroendocrine Carcinomas -- Biphasic Tumors of the Lungs -- Salivary Gland and Adnexal Type Tumors of the Lungs -- Tumors Derived from Presumed Ectopic Tissues -- Vascular Tumors of the Lungs -- Mesenchymal Tumors of the Lungs -- Lung Tumors of Uncertain Histogenesis -- Malignant Lymphomas Involving Lung and Pleura -- Tumors of the Pleura -- Tumor-like Conditions and Benign Tumors of the Lung -- Molecular Pathology of Lung Cancer.
  • Ovid
    Putnam, Angelica R.
    Skin -- Soft tissue -- Joint -- Bone -- Breast -- Central nervous system -- Endocrine -- Head and neck -- Respiratory -- Mediastinum -- Cardiovascular -- Alimentary canal -- Liver/pancreas -- Genitourinary -- Hematopoietic.
  • 2010 ClinicalKey
    Sebire, N. J.
    The aim of this publication is to present a comprehensive and detailed account, which brings together and covers all, or at least most, pediatric surgical pathological entities in a single volume, to allow rapid access for day-to-day use.
  • 2013 Springer
    Taylor, Robert B.
    Which disease should you consider when a young adult has localized bone pain that is dramatically relieved by aspirin? What is sometimes the only physical manifestation of bulimia nervosa? These so-called "old fashioned" historical clues and physical signs are not only part of our medical heritage; their deployment can often spell the difference between prompt clinical diagnosis versus a costly investigative odyssey. Often overlooked with today's emphasis on laboratory testing, a diagnostic pearl such as knowing that a diabetic patient with peripheral neuropathy may actually have metformin-induced vitamin B12 deficiency can be a shortcut to disease recognition.Diagnostic Principles and Applications presents selected literature-based facts and diagnostic insights to help clinicians provide better-informed clinical assessments, avoid medical misadventures, and prepare for their board examinations. The chapters cover:Classic diagnostic pearlsRed flag symptoms and signs of serious illnessBellwether disease indications allowing an occasional early, preemptive diagnosisCounterintuitive clinical manifestations of diseaseCurious clues to specific diagnosesRobert B. Taylor, MD is the author and editor of more than two dozen medical books, including three on the topic of clinical diagnosis, and several hundred published articles. He is a veteran of both rural private practice and chairmanship of a medical school clinical department.
  • 2009 ClinicalKey
    Koerner, Frederick C.
    This new text examines common as well as more difficult diagnostic problems encountered in today's field of breast pathology. The first part of each major section consists of a presentation of general concepts and a detailed description of the pathologic characteristics of specific lesions. Then it focuses on the differences between commonly confused entities and emphasizes pathologic findings to help you obtain the most accurate diagnosis. More than 1,000 illustrations-most in full color-present the key aspects of various diseases in real-life detail.
  • 2012 Springer
    Iacobelli, Stefano; Iovanna, Juan; Russo, Antonio.
    1. Gene Signatures and Soft Tissue Sarcomas: Status of Art and Perspectives / Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe Tonini -- 2. Heterogeneity of Breast Cancer: Gene Signatures and Beyond / Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. Martens -- 3. Gene Signatures in CRC and Liver Metastasis / Daniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio Russo -- 4. Gene Signatures in Gastrointestinal Stromal Tumors / Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybył, and Maria Debiec-Rychter -- 5. Pancreatic Cancer Genetics / Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson Dusetti -- 6. Diagnostic, Prognostic, and Therapeutic Value of Gene Signatures in Non-Small Cell Lung Cancer / Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia Wei -- 7. Gene Signatures in Gastric Cancer / Laura Ottini, Mario Falchetti, and Gabriella Nesi -- 8. Gene Signatures in Colorectal Cancer / Alessandro Lugli and Inti Zlobec -- 9. The Role of Epigenetics in Cancer: From Molecular Function to High-Throughput Assays / Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore Spicuglia -- 10. Primary Epithelial Ovarian Neoplasms: New Concepts Concerning Origin, Pathogenesis and Classification Based on Morphology, Immunomarkers, Molecular Features, and Gene Expression Studies / Bernard Czernobilsky, Leonor Leider-Trejo, Daniele Fanale, and Antonio Russo -- 11. Thyroid Carcinoma: Molecular Signature by Histotype-Specific Mutations and Gene Expression Patterns / Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone.
  • v. 1-2, 1945.
    Rapaport, David; Gill, Merton Max; Schafer, Roy.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008
    Allen, Timothy C.; Beasley, Mary Beth; Cagle, Philip T.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 ClinicalKey
    Gnepp, Douglas R.
    This resource is the authoritative guide to problematic areas of the head and neck for the surgical pathologist. With particular emphasis placed on diagnostic problems and differential diagnosis in addition to coverage of more common diagnostically straightforward lesions, you'll get the most complete diagnostic picture possible. The updated second edition features new coverage and a more user-friendly layout. Expert Consult functionality allows you to access the entire contents of the book online, from any internet connection. Provides clinicopathologic correlations throughout to give you all the information you need to formulate a complete diagnostic report. Features more than 1700 full-color illustrations that capture the pathologic and cytopathologic appearances of the full range of common and rare neoplastic and non-neoplastic lesions. Allows you to access the entire contents of the book online, from any internet connection, via Expert Consult functionality.
  • 1980-
    Sackner, Marvin A.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 Springer
    Bott, Simon; Challacombe, Ben.
    From signs and symptoms to key diagnosis of urological diseases, Diagnostic Techniques in Urology focuses on the current status of urological investigations. This book looks at common conditions of prostate and renal cancer, discusses emergency urological diagnosis, and examines the evaluation of benign diseases as well as miscellaneous urological conditions including erectile dysfunction, incontinence and prostatitis. Bringing together contributions from major international leaders in the field, Diagnostic Techniques in Urology is a useful, easy-to-read book which will benefit urologists and other clinicians interested in urology.
  • 2015 Springer
    Larner, A. J.
    Introduction -- Methods (1): Participants and Test Methods -- Methods (2): Statistical Methods -- Results -- Discussion -- Future prospects for diagnostic test accuracy studies in dementia.
  • 2015 Springer
    Davis, Stephanie D.; Eber, Ernst; Koumbourlis, Anastassios C.
    Over the past 20 years, diagnostic tests for pediatric pulmonologists have revolutionized care of children afflicted with respiratory disorders. These tests have been used to not only help in diagnosis, but also in the management and treatment of these children. Bronchoscopic, imaging and physiologic advances have improved clinical care of these children and have been used as outcome measures in research trials. Diagnostic Tests in Pediatric Pulmonology: Applications and Interpretation describes the various diagnostic modalities (especially the newer ones) that are available for the evaluation of pediatric respiratory disorders. It also provides an understanding of the advantages and limitations of each test so that the clinician may choose the most appropriate ones. An internationally renowned group of authors describe how best to interpret the key findings in a variety of tests as well as the possible pitfalls in incorrect interpretation. This volume focuses on the main diagnostic modalities used in the evaluation of pediatric patients with respiratory disorders and presents up-to-date information on the advantages and limitations of each test for a variety of conditions encountered in the practice of pediatric pulmonology. Clinical utility of these tests is also highlighted. This valuable resource is well suited to practicing clinicians, including pediatric pulmonologists, pediatricians and primary care practitioners, as well as trainees, respiratory therapists and clinical researchers.
  • 2006 CRCnetBASE
    Shung, K. Kirk.
  • 2006
    Kremkau, Frederick W.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 ScienceDirect
    Szabo, Thomas L.
    Diagnostic Ultrasound Imaging provides a unified description of the physical principles of ultrasound imaging, signal processing, systems and measurements. This comprehensive reference is a core resource for both graduate students and engineers in medical ultrasound research and design. With continuing rapid technological development of ultrasound in medical diagnosis, it is a critical subject for biomedical engineers, clinical and healthcare engineers and practitioners, medical physicists, and related professionals in the fields of signal and image processing. The book contains 17 new and updated chapters covering the fundamentals and latest advances in the area, and includes four appendices, 450 figures (60 available in color), and almost 1,500 references. In addition to the continual influx of readers entering the field of ultrasound worldwide who need the broad grounding in the core technologies of ultrasound, this book provides those already working in these areas with clear and comprehensive expositions of these key new topics as well as introductions to state-of-the-art innovations in this field. Enables practicing engineers, students and clinical professionals to understand the essential physics and signal processing techniques behind modern imaging systems as well as introducing the latest developments that will shape medical ultrasound in the futureSuitable for both newcomers and experienced readers, the practical, progressively organized applied approach is supported by hands-on MATLAB code and worked examples that enable readers to understand the principles underlying diagnostic and therapeutic ultrasound. Covers the new important developments in the use of medical ultrasound: elastography and high-intensity therapeutic ultrasound. Many new developments are comprehensively reviewed and explained, including aberration correction, acoustic measurements, acoustic radiation force imaging, alternate imaging architectures, bioeffects: diagnostic to therapeutic, Fourier transform imaging, multimode imaging, plane wave compounding, research platforms, synthetic aperture, vector Doppler, transient shear wave elastography, ultrafast imaging and Doppler, functional ultrasound and viscoelastic models.
  • 2013 ClinicalKey
    Rumack, Carol M.
    Also available: Print – v. 1-2, 2011.
  • 2006
    Barber, Janet.
    PrintStatus: Not Checked OutLane Catalog Record
  • v. 1-2, 1896-97. Google Books
    Fulltext (v.2 1896) Google Books
    Boas, Ismar; Boas, Ismar.
  • 1906 Google Books
    Jung, C. G.
    Also available: Print – 1906-
  • 1922
    Hautkrankheiten / S. Bettmann -- Venerische Krankheiten / E. Riecke.
  • 2008 Springer
    Banathy, Bela H.; Jenlink, Patrick M.
  • 2015 Springer
    Kalva, Sanjeeva P.; Wu, Steven.
    This practical book covers the basic principles and practice of dialysis access management, a crucial part of the care of patients undergoing hemodialysis. It has been written in an easy-to-read, step-by-step format to help facilitate learning and understanding of the procedures, and has been supplemented with numerous operative photographs and diagrams demonstrating the commonly performed dialysis access exams, interventions, procedures and surgeries. Dialysis Access Management is an essential text for residents, fellows, and physicians who are learning or practicing in dialysis and/or dialysis access management, especially in the fields of nephrology, radiology, surgery, and vascular medicine.
  • 2011 Springer
    Guandalini, Stefano; Vaziri, Haleh.
    Definition, epidemiology, pathophysiology, clinical classification, and differential diagnosis of diarrhea -- Infectious gastroenteritis and colitis -- Inflammatory bowel disease -- Eosinophilic enteritis -- Microscopic colitis -- Food allergy -- Protein-losing enteropathies -- Radiation enterocolitis -- Congenital disorders of digestion and absorption -- Pancreatic exocrine insufficiency -- Bacterial overgrowth -- Celiac disease -- Whipple disease -- Surgical conditions presenting with diarrhea -- Chronic diarrheal disorders due to endocrine neoplasms -- Diarrhea from enterotoxins -- Factitious diarrhea -- Chronic idiopathic diarrhea -- Irritable bowel syndrome -- Functional diarrhea (non-specific chronic diarrhea, toddler diarrhea) -- Diarrhea related to non-neoplastic endocrine diseases -- Alcohol-related diarrhea -- Drug-induced diarrhea -- Runner's diarrhea -- Evaluation of patients with diarrhea and timing of referral -- Empiric treatment of chronic diarrhea -- Probiotics for diarrheal diseases.
  • 2008 Springer
    Smiseth, Otto A.; Tendera, Michał.
  • 2008 ClinicalKey
    Garcia, Mario J.; Klein, Allan L.
    This reference equips you to successfully diagnose and manage even the most complex incidences of diastolic heart failure and their comorbidities. It examines the basic mechanisms of this condition through discussions of both cellular and anatomic causes; guides you through non-invasive techniques for diagnosis, including echocardiography, cardiac CT, and MRI; and provides expert advice on pharmacologic management. Case examples on the accompanying CD-ROM provide a greater understanding of the diagnostic process. Covers the basic mechanisms of diastolic heart problems from both cellular and anatomic perspectives. Features in-depth assessments of all diagnostic methods for diastolic heart failure, including rationales for their use. Examines contributing conditions that play a role in diastolic heart failure and offers guidance on their management. Offers pharmacologic strategies for multiple problem management.
  • 1999 Wiley
    Day, Simon.
  • Knovel
    Stenesh, J.
    Also available: Print – 1989
  • Bélanger, Réal; Cook, Ramsay.
  • 2006 CRCnetBASE
    Collins, P. M.
  • 2001 CRCnetBASE
    Cavagnaro, Catherine; Haight, William T.
  • 2007 Springer
    Frosch, Peter J.; Le Coz, C.J; Lepoittevin, J.-P.
    Dictionary of Contact Allergens: Chemical Structures, Sources and References / Christophe J. Le Coz and Jean-Pierre Lepoittevin, p. 1-254 -- Patch Testing with the Patients' Own Products / Peter J. Frosch, Johannes Geier, Wolfgang Uter and An Goossens, p. 255-280.
  • 2013 Springer
    Gunn, S. William.
    In times of emergency, clear communication is critical to saving lives and preventing further destruction. Operations in the field, negotiations between governments and relief organizations, and planning and training sessions all require collaboration among people from various disciplines using different terminologies. Without a common lexicon, misunderstandings and other communication errors can lead to the loss of valuable time, scarce resources, and lives--and during an era marked by climate disasters, warfare, industrial accidents, and threats of bioterrorism, the stakes are increasingly high. It is in this spirit that the original Dictionary of Disaster Medicine and Humanitarian Relief was assembled, and the same holds true for this timely Second Edition. This practical resource boasts more than twice the number of entries as the first edition: definitions, abbreviations, and acronyms covering all phases of humanitarian aid, from planning and preparedness to rescue and recovery. Its contents have been field-tested across the emergency intervention community, and are as useful in communicating with the media and the public as with colleagues. This expanded edition of the Dictionary of Disaster Medicine and Humanitarian Relief ably follows its predecessor as an authoritative resource for researchers and professionals in global health, health promotion, public health, public health policy, and disaster management.
  • 2008
    Greenland, Sander; Last, John M.; Porta, Miquel S.
    PrintStatus: Not Checked OutLane Catalog Record
  • 1973-
    Gastaut, Henri.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2004 CRCnetBASE
    Yannai, Shmuel.
  • 2006
    King, Robert C.; Mulligan, Pamela Khipple; Stansfield, William D.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010 Springer
    Blom, Jan Dirk.
  • 2008 CRCnetBASE
    Blunt, John; Munro, Murray H. G.
  • v. 1-5, 2007.
    Bynum, Helen; Bynum, W. F.
    PrintStatus: Not Checked OutLane Catalog Record
    The index is found in v. 5 along with separate lists of individuals by country, by fields of activity, and in chronological order by birth year.
  • Raso, Jack.
  • 2006
    Singleton, Paul; Sainsbury, Diana.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 Springer
    Larner, A. J.
  • 2011 Springer
    Larner, A. J.
  • 2006 CRCnetBASE
    Eskin, N. A. M.; Tamir, Snait.
  • 2005 CRCnetBASE
    Gosling, Peter J.
  • 2013 Springer
    Nahler, Gerhard.
    This dictionary details various terms typically used in pharmaceutical medicine. It also explains commonly used abbreviations.
  • 2006
    Colman, Andrew M.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2001 CRCnetBASE
    Basu, Dipak.
  • 2009 Springer
    Clague, Roy B.; Payer, Juraj; Rovenský, Jozef.
  • 2009
    Mahy, B. W. J.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 Springer
    Lepoittevin, J.-P; Frosch, Peter J.; Le Coz, C. J.
  • 2013 Springer Protocols
    Eichinger, Ludwig; Rivero-Crespo, Francisco.
    Amoebozoa / Christina Schilde and Pauline Schaap -- Model organism Dictyostelium discoideum / Salvatore Bozzaro -- Comparative genomics of the dictyostelids / William F. Loomis -- One stop shop for everything Dictyostelium : dictyBase and the dicty stock center in 2012 / Petra Fey [and others] -- Fluorescent reporters and methods to analyze fluorescent signals / Annette Müller-Taubenberger and Hellen C. Ishikawa-Ankerhold -- Collection and cultivation of dictyostelids from the wild / Tracy E. Douglas [and others] -- Identification and verification of microRNAs by high-throughput sequencing / Jimmie Hällman [and others] -- Transcriptional profiling of Dictyostelium with RNA sequencing / Edward Roshan Miranda [and others] -- Analysis of chromatin organization by deep sequencing technologies / James L. Platt [and others] -- Pharmacogenetics of resistance to cisplatin and other anticancer drugs and the role of sphingolipid metabolism / Stephen Alexander, William S. Swatson, and Hannah Alexander -- N-glycomic and n-glycoproteomic studies in the social amoebae / Christa L. Feasley -- Measuring cheating, fitness, and segregation in Dictyostelium discoideum / Neil J. Buttery [and others] -- Application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci / Jan Faix [and others] -- Extrachromosomal inducible expression / Douwe M. Veltman and Peter J.M. Van Haastert -- Isolation of Dictyostelium nuclei for light and electron microscopy / Petros Batsios [and others] -- Investigation of DNA repair pathway activity / Anne-Marie C. Couto, Nicholas D. Lakin, and Catherine J. Pears -- Transcript localization in Dictyostelium discoideum cells by RNA FISH / Patrick Hofmann, Janis Kruse, and Christian Hammann -- Analysis of mitochondrial gene expression / Jessica E. Accari [and others] -- Mitochondrial respiratory complex function and the phenotypic consequences of dysfunction / Sarah J. Annesley [and others] -- Micropipette aspiration for studying cellular mechanosensory responses and mechanics / Yee-Seir Kee and Douglas N. Robinson -- Quantitative analysis of phagocytosis and phagosome maturation / Natascha Sattler, Roger Monroy, and Thierry Soldati -- Setting up and monitoring an infection of Dictyostelium discoideum with mycobacteria / Sonia Arafah [and others] -- Isolation of pathogen-containing vacuoles / Olga Shevchuk and Michael Steinert -- Immunomagnetic purification of fluorescent legionella-containing vacuoles / Ivo Finsel, Christine Hoffmann, and Hubert Hilbi -- Secretory lysosomes in Dictyostelium : visualization, characterization, and dynamics / Wanessa C. Lima and Pierre Cosson -- Monitoring autophagy in Dictyostelium / Ana Mesquita [and others].
  • 2006 Springer Protocols
    Eichinger, Ludwig; Rivero-Crespo, Francisco.
  • v. 1-, 2010- Springer
  • 2015 Springer
    Patel, Vinood B.; Preedy, Victor R.; Rajendram, Rajkumar.
  • 2011 CRCnetBASE
    Preedy, Victor R.
  • 2012 CRCnetBASE
    Kanarek, Robin B.; Lieberman, Harris R.
    Mental energy and fatigue : science and the consumer / Harris R. Lieberman -- Hydration and brain function / Kristen E. D'Anci -- Diet as an analgesic modality / Alexis M. Codrington, Yoram Shir, and John Pereira -- Breakfast and adult and children behaviors / Andrew P. Smith -- Diet, physical activity, and substrate oxidation : implications for appetite control, weight loss, and body composition / Mark Hopkins, Neil A. King, and John E. Blundell -- The reward deficiency hypothesis : implications for obesity and other eating disorders / Brenda M. Geiger, Erin N. Umberg, and Emmanuel N. Pothos -- Potential consequences of obesity on cognitive behavior / Nicole A. Jurdak and Robin B. Kanarek -- Dietary supplements for weight loss / Igho Onakpoya and Edzard Ernst -- Sweet taste preferences and cravings in gestational diabetes mellitus (GDM) : implications for diet and medical management / Beverly J. Tepper ... [et al.] -- Homocysteine, B vitamins, and cognitive function / Joshua W. Miller -- Creatine, brain functioning, and behavior / Patricia J. Allen, Kristen E. D'Anci, and Robin B. Kanarek -- Theanine, mood, and behavior / Jessica E. Smith and Peter J. Rogers -- Caffeine : practical implications / Andrew P. Smith -- Caffeine effects on aggression and risky decision making / Caroline R. Mahoney, Tad T. Brunyé, and Grace E. Giles.
  • 2005 Karger
    Elmadfa, I.
    Fat intake, diet variety, and health promotion / Elmadfa, I., Freisling, H. -- Mixed diet in Europe : a historical overview / Spiekermann, U. -- Influences on food choice and dietary behavior / Shepherd, R. -- Age and gender dependent profile of food choice / Westenhoefer, J. -- Diversification in indigenous and ethnic food culture / Wahlqvist, M.L. -- Organic foods : do they have a role? / Kpke, U. -- Impact of 'functional food' / Guesry, P.R. -- The role of fortified foods : situation in Austria / Wagner, K.-H. ... [et al.] -- Attitudes of Austrian adults to the consumption of fruits and vegetables / Rust, P., Elmadfa, I. -- Health effects of phytoestrogens / Branca, F., Lorenzetti, S. -- Exploitation of convenience food in view of a diet diversification for better nutrition / Berghofer, E. -- Adulteration of foodstuffs : from misleading to poisoning / Bnti, D. -- Macro- and micronutrients in a traditional Greek menu / Trichopoulou, A., Vasilopoulou, E., Georga, K. -- Vegetarian diets : what are the advantages? / Leitzmann, C. -- Food safety and consumers' attitude in a new EU member state : a case study of Hungary / Bnti, D., Lakner, Z. -- Making the healthy choice an easy choice : from nutrition science to consumer action / Verschuren, P.M. -- Diversification and food choice, the consumer's view / Kettlitz, B.
  • 2014 CRCnetBASE
    Ardies, Curtis Murray.
    "The idea of producing a book on the prevention of chronic diseases through exercise and diet was intriguing for me when I was first approached with the idea. I had been teaching nutrition, exercise, and health science courses with a focus on cellular aspects of prevention for many years and had to develop all of my own materials because very few books were available. And of those that were, they had a decided clinical approach with very little discussion about the actual biochemistry or molecular mechanisms involved in prevention. When I broached the concept with several potential coauthors, the prevailing opinion was that books that covered biochemical and molecular aspects of disease etiology also were in very short supply. Thus this book was born: an attempt to collate the latest cellular- and molecularbased research on the etiology of chronic diseases with how these mechanisms of cause are modified by various aspects of diet and exercise. Essentially, we have tried to produce a text that translates molecular-based data on etiology and prevention into a clinical prescription for the prevention of chronic disease. The focus on diabetes, atherosclerosis, osteoporosis, cancer, and degenerative neurological disease is because they are the major causes of morbidity and mortality by chronic disease and also because there is sufficient molecular evidence for a strong dietary and activity (or rather, an insufficiency of both) component to their etiology. The inclusion of a separate chapter on "Inflammation" became necessary when it was clear that inflammatory signaling is a fundamental component of each of these diseases and that reducing inflammation is key to reducing risk for all of these diseases. At the time we started, obesity had not yet been declared a diseas"-- Provided by publisher.
  • 2012 CRCnetBASE
    Anderson, John J. B.; Garner, Sanford C.; Klemmer, Philip J.
    "Presenting recent advancements in research findings and the resulting new schools of thought on the physiology of human bone, this comprehensive reference examines information on dietary pattern and specific nutrients in bone health. Written by experts in the areas of nutrition, bone function, and medicine, chapters include research on a variety of bone-related topics including effects of vitamins, nutrients, and antioxidants; dietary requirements; physical exercise; bone hormones; lifestyle and effects through the life cycle; race and ethnicity; and prevention of bone diseases including osteopenia and osteoporosis"-- Provided by publisher.
  • v. 1-2, 2013 Springer
    vol. 2 Springer
    Hunter, Lan-Anh; Patel, Vinood B.; Preedy, Victor R.
  • 2010 Springer
    Preedy, Victor R.; Watson, Ronald R.; Zibadi, Sherma.
  • 2006 CRCnetBASE
    Huang, Yung-Sheng; Knapp, Howard R.; Yanagita, Teruyoshi.
    Lipid analysis and lipidomics / Magdi M. Mossoba ... [et al.], editors -- An overview of modern mass spectrometry methods in the toolbox of lipid chemists and biochemists / R. Moreau --Techniques and applications in lipid analysis / Nils Hinrichsen and Hans Steinhart -- Recent advances in silver-ion HPLC utilizing acetonitrile in hexane as solvent / R.O. Adlof -- TLC-FID with special reference to marine lipids and other high-molecular-weight organic compounds / R.G. Ackman and A. Timmins -- Analysis of trans-18:1 fatty acids by silver ion HPLC / P. Delmonte and M.P. Yurawecz -- Lipid separations using packed-column SFC / D.G. Hayes -- LC-MS and chiral separation / A. Kuksis -- LC-MS and lipid oxidation / A. Kuksis -- Structural analysis of unsaturated fatty acid methyl ester isomers with acetonitrile covalent adduct chemical ionization (CACI) / J.T. Brenna -- Fast GC for cellular FAME analysis of bacteria / J.S. Buyer -- Use of cellular fatty acids to identify food-borne pathogens by infrared spectroscopy and capillary GC / M.M. Mossoba -- Infrared spectroscopy and partial least square calibration in the simultaneous quantification of isolated trans and conjugated linoleic acids / Alfred A. Christy -- Global cellular lipidome analyses by shotgun lipidomics using multidimensional mass spectrometry / X. Han and R.W. Gross -- Waxes and sterols / E.J. Paris and A.D. Bell -- Analysis of biological tissue and edible fat / J.K.G. Kramer -- Investigation of protein-lipid interactions by vibrational spectroscopy / E.C.Y. Li-Chan, G. Meng, and N.K. Howell -- Fat replacers / W.E. Artz -- High-performance size-exclusion chromatography for lipid analysis in organic media / M.C. Dobarganes and G. Marquez-Ruiz -- Phospholipids / M.C. Erickson.
  • 2012 CRCnetBASE
    Almeida, Nelson; Cho, Sungsoo.
    "Preface: Fiber offers a variety of health benefits and is essential to reduce the risk of such chronic diseases as diabetes, obesity, cardiovascular disease, and diverticulitis. According to the Institute of Medicine (IOM), adequate intake (AI) of total fiber should be 14 g/1000 kcal. The IOM recommendation is joined by those from a variety of government public health agencies that promote increased fiber consumption, but a majority of people in developed countries still fall short of recommended values. On average, Americans consume only half of required intake, and approximately 90% of the U.S. population fails to meet AI goals. The problem stems largely from the fact that most conventional high-fiber foods are not tasty. Their organoleptic properties lack the kind of sensory attributes that people seek in the foods they eat. This makes it imperative for food companies to formulate tasty foods with high fiber content to improve population-wide consumption. Many have done so with new fiber ingredients that satisfy consumer demands while also delivering the health benefits of fiber. This book discusses findings from the Ninth Vahouny Fiber Symposium, which was held in Bethesda, Maryland, in June 2010. It includes a definition of fiber developed through expert consensus and delves into the many health benefits of fiber, including its prebiotic effects and roles in weight management, glycemic control, cardiovascular health, and intestinal regularity. It also reviews a variety of fiber ingredients that can be used in many appealing foods. The book provides details of claim opportunities for fiber ingredients and fiber-containing foods as well as a list of global suppliers of these ingredients. It is designed for use by food product developers, nutritionists, dietitians, and regulatory agencies"--Provided by publisher.
  • USDA
  • 1983-
    Harlan, William R.
    pt. 1. Blood pressure correlates -- pt. 2. Serum urate, serum cholesterol, and correlates
  • 2010 Springer
    Calviello, Gabriella; Serini, Simona.
  • 2012 Springer
    Patra, Amlan K.
    An Overview of Antimicrobial Properties of Different Classes of Phytochemicals / Amlan Kumar Patra -- Antimicrobial Properties of Flavonoids / Luisa Pistelli and Irene Giorgi -- Antiviral Properties of Phytochemicals / Ai-Lin Liu and Guan-Hua Du -- Antimicrobial Properties of Organosulfur Compounds / Osman Sagdic and Fatih Tornuk -- Antimicrobial Activities of Essential Oils / Danuta Kalemba, Martyna Matla and Anna Smętek -- Phytochemicals Against Drug-Resistant Microbes / Manuel Sim{tilde}oes, Madalena Lemos and Lúcia C. Sim{tilde}oes -- Phytochemicals as Anti-microbial Food Preservatives / Mehrdad Tajkarimi and Salam A. Ibrahim -- Dietary Tannins on Microbial Ecology of the Gastrointestinal Tract in Ruminants / Amlan Kumar Patra, Byeng-Ryel Min and Jyotisna Saxena -- Manipulating Ruminal Biohydrogenation by the Use of Plants Bioactive Compounds / Valentina Vasta and Rui J. B. Bessa -- Essentials Oils and Rumen Microbial Populations / Malgorzata Szumacher-Strabel and Adam Cieślak -- Saponins: Effects on Rumen Microbial Ecosystem and Metabolism in the Rumen / Elizabeth Wina -- Effect of Plant Secondary Metabolites on Rumen Methanogens and Methane Emissions by Ruminants / Devki Nandan Kamra, Mahesh Pawar and Beddyuti Singh -- Phytochemicals and Gut Microbial Populations in Non-ruminants / Artabandhu Sahoo and Nira Manik Soren.
  • 2012 CRCnetBASE
    Antonio, Jose; Lowery, Lonnie Michael.
    "There has been a long standing controversy in the field of sports nutrition regarding the role of protein and protein metabolism in muscle development and athletic performance. The understanding of protein nutrition has changed dramatically over the last decade and this book aims to clarify and modernize the topic. This book presents the efficacy, safety, and recommendations of protein intake among strength athletes. Including case studies, the text covers historical perspectives of protein use; safety of high protein diets; specific protein types and timing of intake; weight control using protein; protein synthesis and breakdown; and nitrogenous compounds/supplements"--Provided by publisher.
  • 2005 NAP
    Also available: Print – 2005
  • 2009/2010
    Greer, Eric Lieberman.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2002 NAP
    Also available: Print – 2002
  • Oreglia, Anthony; Ciarcia, Janet.
    Also available: Print – 1996.
  • 2007
    Goodman, Catherine Cavallaro; Snyder, Teresa E. Kelly.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 Springer
    Jackson, Scott M.; Nesbitt, Lee T.
    1. The Chief Complaint -- 2. The Past Medical History, Social History, and Review of Systems -- 3. The Physical Exam -- 4. The Biopsy -- 5. The Laboratory Results -- 6. The Diagnosis -- 7. Glossary.
  • 2008 Springer
    Jackson, Scott M.; Nesbitt, Lee T.
  • 2012 Thieme Book
    Burgener, Francis A.; Herzog, Christopher; Meyers, Steven P.; Zaunbauer, Wolfgang.
    "This unique, findings-oriented guide to computed tomography is organized to reflect the way radiologists really work: progressing from general impressions to definitive diagnoses. In nearly 1000 high-quality scabs, the radiologist will find CT findings depicting frequently encountered congenital and acquired diseases and disorders. Included in the wide-ranging survey of CT findings are traumatic injuries; congenital anomalies; and infectious, inflammatory, neoplastic, and degenerative disease processes. For convenience, these are grouped anatomically by brain, head and neck, spine, musculoskeletal system, chest, abdomen, and pelvis. In addition, the book's extensive index systematically cross-references diseases and CT findings, providing even greater accessibility to key information"--Provided by publisher.
  • 2008 Thieme Book
    Burgener, Francis A.; Kormano, Martti; Pudas, Tomi.
    Bone. Osteopenia / Francis A. Burgener -- Osteosclerosis / Francis A. Burgener -- Periosteal reactions / Francis A. Burgener -- Trauma and fractures / Francis A. Burgener -- Localized bone lesions / Francis A. Burgener -- Joint diseases / Francis A. Burgener -- Joint and soft-tissue calcification / Martti Kormano and Tomi Pudas -- Skull / Francis A. Burgener -- Orbits / Francis A. Burgener -- Nasal fossa and paranasal sinuses / Francis A. Burgener -- Jaws and teeth / Francis A. Burgener -- Spine and pelvis / Martti Kormano and Tomi Pudas -- Clavicles, ribs, and sternum / Martti Kormano and Tomi Pudas -- Extremities / Francis A. Burgener, Martti Kormano, and Tomi Pudas -- Hands and feet / Martti Kormano and Tomi Pudas -- Chest. Cardiac enlargement / Martti Kormano and Tomi Pudas -- Mediastinal or hilar enlargement / Martti Kormano and Tomi Pudas -- Pleura and diaphragm / Martti Kormano and Tomi Pudas -- Intrathoracic calcifications / Martti Kormano and Tomi Pudas -- Alveolar infiltrates and atelectasis / Francis A. Burgener -- Interstitial lung disease / Francis A. Burgener -- Pulmonary edema and symmetrical bilateral infiltrates / Francis A. Burgener -- Pulmonary nodules and mass lesions / Francis A. Burgener -- Pulmonary cavitary and cystic lesions / Francis A. Burgener -- Hyperlucent lung / Martti Kormano and Tomi Pudas -- Abdomen. Abnormal abdominal gas patterns and dilatation and motility disorders in the gastrointestinal tract / Francis A. Burgener and Martti Kormano -- Abdominal calcifications / Martti Kormano and Francis A. Burgener -- Abnormal mucosal pattern in the gastrointestinal tract / Martti Kormano and Tomi Pudas -- Narrowing in the gastrointestinal tract / Francis A. Burgener -- Filling defects in the gastrointestinal tract / Francis A. Burgener -- Ulcers, diverticula, and fistulas in the gastrointestinal tract / Martti Kormano and Tomi Pudas -- Gallbladder and bile duct abnormalities / Francis A. Burgener -- Abnormal renal papillae and calices / Francis A. Burgener -- Filling defects in the urinary tract / Francis A. Burgener -- Urinary tract obstructuion and dilatation / Francis A. Burgener.
  • v. 1-2, 1992-2001.
    Ackerman, A. Bernard.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 Thieme Book
    Siegenthaler, Walter.
  • 2007 Ovid
    Greenspan, Adam; Jundt, Gernot; Remagen, Wolfgang.
    Radiologic and pathologic approach to bone tumors -- Bone-forming (osteogenic) lesions -- Cartilage (chondrogenic) lesions -- Fibrogenic, fibroosseous, and fibrohistiocytic lesions -- Round cell lesions -- Vascular lesions -- Miscellaneous tumors and tumor-like lesions -- Metastases -- Tumors and tumor-like lesions of the joints.
    Also available: Print – 2007
  • 2013 Springer
    Bonifazi, E.
    Differential diagnosis in pediatric dermatology requires not only a direct experience in the field, but also an inclination to symptoms observations and analysis.This book, the first exclusively devoted to this topic, covers the full range of relevant conditions: inherited skin disorders; nevi; viral, bacterial, fungal, and parasitic infections; acne; allergic diseases; autoimmune skin disorders; connective tissue diseases; tumors; and miscellaneous conditions. Each chapter addresses the differential diagnosis between two (or occasionally three or four) dermatological conditions. All chapters are just two pages long, containing between two and six images and a very short text emphasizing the clinical differences between the diseases in question. At the end of each chapter, a summary highlights one or two characteristics essential for the differential diagnosis. The volume will represent an ideal tool for pediatric dermatologists, pediatricians, and GPs, and will help them in the diagnosic process.
  • 201 Thieme Book
    Blickman, Johan G.; Rijn, Rick R. van.
    "Efficiency is the key word at the heart of the concept for this diagnostic atlas - efficiency of presentation and diagnostic efficiency achieved through its use. The contents are arranged in chapters according to organ or body part. Each chapter begins with a list of the radiographic findings referring to the relevant table/page number for that finding. The text within these tables is presented under three columns: possible diagnoses, radiographic findings, and general comments. Corresponding sample images of the highest quality are then provided for the more common conditions throughout. Rare diseases are marked with asterisks and are illustrated where appropriate. The hard-pressed radiologist will welcome this work as an efficient and reliable guide to the interpretation of pediatric images"--Provided by publisher.
  • 2008 Ovid
    Collins, R. Douglas.
    Also available: Print – 2008
  • 2012 Ovid
    Collins, R. Douglas.
  • 2006 Thieme Book
    Schmidt, Guenter.
    Also available: Print – 2006
  • 2007
    Seller, Robert H.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 ClinicalKey
    Seller, Robert H.; Symons, Andrew B.
    This 6th Edition, by Drs. Robert H. Seller and Andrew B. Symons, helps you quickly and efficiently diagnose the 36 most common symptoms reported by patients. Organized alphabetically by presenting symptom, each chapter mirrors the problem-solving process most physicians use to make a diagnosis. It's a practical, clinically oriented approach that can help you master the differential diagnosis of common symptoms and diagnose almost all the problems typically seen in your practice. Find the guidance you need quickly through an alphabetical organization by presenting symptom and a concise, consistent, user-friendly approach that mirrors the diagnostic decision-making process. Get a fresh perspective from new co-author, Dr. Andrew B. Symons, who brings a strong background in education as Vice Chair of Medical Student Education at SUNY Buffalo.
  • 2014 Springer
    Rana, Abdul Qayyum; Hedera, Peter.
    This practical, pocket-sized, quick reference book is for those who need to manage movement disorder patients without the immediate help of a movement disorder neurologist. Only the most pertinent information is covered. This book is divided into five chapters covering the common phenomenology of movement disorders and includes tremor, dystonia, chorea, myoclonus, and tics. The etiology, pathophysiology, symptoms and treatments of these conditions are briefly reviewed, with the emphasis on the most common practical challenges encountered with these patients. Differential Diagnosis of Movement Disorders in Clinical Practice is aimed at postgraduates training in neurology, emergency care physicians, internists and primary care providers. Medical students will also find this book particularly helpful during their neurology rotations.
  • 2005 Springer Protocols
    Liang, Peng; Meade, Jonathan D.; Pardee, Arthur B.
    Global analysis of gene expression by differential display : a mathematical model / Shitao Yang and Peng Liang -- Automation of fluorescent differential display with digital readout / Jonathan D. Meade ... [et al.] -- Ordered differential display / Mikhail V. Matz and Ella A. Meleshkevitch -- GeneCalling : transcript profiling coupled to a gene database query / Richard A. Shimkets -- High-density sampling differential display of prokaryotic mRNAs with RAP-PCR / Dana M. Walters and Pierre E. Rouviere -- Vertical arrays : microarrays of complex mixtures of nucleic acids / Rosana Risques ... [et al.] -- Automated pattern ranking in differential display data analysis / Tero Aittokallio ... [et al.] -- Linking cDNA-AFLP-based gene expression patterns and ESTs / Ling Qin, Pjotr Prins, and Johannes Helder -- Differentially expressed genes associated with hepatitis B virus HBx and MHBs protein function in hepatocellular carcinoma / Dae-Ghon Kim -- Identification of disease markers by differential display : prion disease / Michael Clinton ... [et al.] -- Saturation screening for p53 target genes by digital fluorescent differential display / Yong-Jig Cho ... [et al.] -- Identification of p53-regulated genes by the method of differential display / Yunping Lin, Roger P. Leng, and Samuel Benchimol -- Identification by differential display of IL-24 autocrine loop activated by ras oncogenes / Zhongjia Tan, Mai Wang, and Peng Liang -- Comprehensive analysis of ovarian gene expression during ovulation using differential display / Lawrence L. Espey -- Functional analysis of nocturnin : a circadian clock-regulated gene identified by differential display / Julie E. Baggs and Carla B. Green -- Isolation and characterization of anthocyanin 5-0-glucosyltransferase in perilla frutescens var. crispa by differential display / Mami Yamasaki and Kazuki Saito -- Identification of target genes of a yeast transcriptional repressor / Bernard Mai and Linda L. Breeden -- Detection of an mRNA polymorphism by differential display / Shan Liang ... [et al.] -- Silencing in yeast : identification of CLr4 targets / Sergey V. Ivanov and Alla V. Ivanova -- Identification of mRNA bound to RNA binding proteins by differential display / Anne Carr-Schmid, Xinfu Jiao, and Megerditch Kiledjian.
  • 2013 Springer
    Cooper, Richard M.; Glick, David B.; Ovassapian, Andranik.
    The Difficult Airway provides comprehensive textual and visual coverage of how to deal with patients who have expected or unexpected difficult airways. The book begins with a review of current definitions of the difficult airway, its incidence, and the evolution of algorithms to facilitate its management. The chapters that follow offer a comprehensive update on the techniques and concepts described in the American Society of Anesthesiologists' Difficult Airway Algorithm. Noted experts in each of the techniques have been recruited by the book editors to present the information. Figures throughout the book illustrate important points and procedures. This is a wonderful resource for health care professionals who are concerned with the management of the difficult airway, including anesthesiologists, intensive care physicians, emergency room physicians, nurses, and out-of-hospital first responders.
  • 2015 Springer
    Alió, Jorge L.
    This richly illustrated book is intended as a gold standard for the refractive surgeon. It complements the authors? successful previous book, Management of Complications in Refractive Surgery, by providing detailed practical information on the management of specific cases. Worldwide leaders in the field document a wide range of challenging cases drawn from their own clinical practice. These cases relate to the planning of refractive laser treatment; intraoperative complications when using LASIK (Microkeratome and Femtosecond) and various surface treatments, including PRK, PTK, and EpiLASIK; early and late postoperative complications with these treatments; and a range of other complications that may arise during or after refractive surgery. This book will be an indispensable aid for the refractive surgeon and will assist in decision making when the surgeon is confronted by a difficult case.
  • 2013 Springer
    Al-Kandari, Ahmed M.; Desai, Mahesh; Shokeir, Ahmed A.; Shoma, Ahmed M.; Smith, Arthur D.
    1. Introduction / Ahmed M. Al-Kandar -- 2. Anesthetic Considerations During Endourologic Surgery / Ahmed M. Labib and Ahmed M. Al-Kandari -- 3. Difficulties in Instrumentation of Endourologic Procedures / Ahmed M. Al-Kandari -- 4. Percutaneous Management of Calyceal Diverticula: An American Experience / Jessica A. Mandeville, Ehud Gnessin, and James E. Lingeman -- 5. Managing Bleeding During Percutaneous Renal Surgery / Ahmed R. El-Nahas, Ahmed M. Shoma, and Ahmed A. Shokeir -- 6. Septic Complications During Percutaneous Nephrolitholotomy (PCNL) / Evangelos Liatsikos and Panagiotis Kallidonis -- 7. Visceral Complications of Percutaneous Nephrolithotomy (PCNL) / Abdelghaffar S. Arafa and Ahmed M. Al-Kandari -- 8. Percutaneous Nephrolithotomy (PCNL) for Staghorn Calculi: The Rigid Approach: Overcoming the Difficulties / Arvind P. Ganpule and Mahesh Desai -- 9. Flexible Renal Nephroscopy: Overcoming the Difficulties / Joseph A. Graversen, Adam C. Mues, and Mantu Gupta -- 10. Chinese Minimally Invasive Percutaneous Nephrolithotomy (MPCNL): Overcoming the Difficulties / Zhaohui He, Guohua Zeng, and Xun Li -- 11. Percutaneous Renal Surgery for Renal Pelvic Tumors: Overcoming the Difficulties / Brian Duty, Michael Blute, Zhamshid Okhunov, Arthur D. Smith, and Zeph Okeke -- 12. Percutaneous Nephrolithotomy (PCNL) in the Treatment of Stones within Horseshoe Kidneys and in Patients with Autosomal Dominant Polycystic Kidney Disease / Ahmed Abed, Ahmed R. El-Nahas, Ahmed M. Al-Kandari, and Ahmed A. Shokeir -- 13. Drainage Systems After Percutanous Renal Procedures / Brian Duty, Zhamshid Okhunov, Arthur D. Smith, and Zeph Okeke -- 14. Retrograde Nephrostomy Access: Overcoming the Difficulties / Khalid Matar Al-Otaibi -- 15. Percutaneous Nephrolithotomy (PCNL): The Supine Approach: Overcoming the Difficulties / Francisco Pedro Juan Daels -- 16. Percutaneous Nephrolithotomy (PCNL) in Obese Patients: Overcoming the Difficulties / Soroush Rais-Bahrami and Arthur D. Smith -- 17. Percutanous Nephrolithotomy (PCNL) for Caliceal Diverticulum: An Egyptian Experience / Ahmed Mohamed Elshal, Ahmed M. Shoma, and Ahmed A. Shokeir -- 18. Endourological Management of Urological Complications Following Renal Transplantation / Ahmed S. El-Hefnawy, Mohamed M. Elsaadany, Shady A. Soliman, Yasser Osman, Ahmed M. Shoma, and Ahmed A. Shokeir -- 19. Difficult Situations in Percutaneous Nephrolithotomy (PCNL) for Solitary Kidney and Renal Failure / Arvind P. Ganpule, Amit Satish Bhattu, and Mahesh Desai -- 20. Percutaneous Nephrolithotomy (PCNL) and Other Simultaneous Procedures / Ravindra B. Sabnis, Raguram Ganesamoni, and Amit Doshi -- 21. Adult Endopyelotomy: Overcoming the Difficulties / Zhamshid Okhunov, Brian Duty, Zeph Okeke, and Arthur D. Smith -- 22. Ureteroscopy for Upper Ureteral Stones: Overcoming the Difficulties of the Rigid Approach / Tamer S. Barakat, Ahmed R. El-Nahas, Ahmed M. Shoma, and Ahmed A. Shokeir -- 23. Uretheroscopy for Upper Ureteric and Renal Stones: Overcoming Difficulties with the Flexible Approach / Jacob Howard Cohen and Michael Grasso III -- 24. Ureteroscopy for Ureteral Strictures / Ahmed M. Harraz, Ahmed M. Shoma, and Ahmed A. Shokeir -- 25. Ureteroscopic Management of Ureteral and Renal Pelvic Tumors: Overcoming the Difficulties / Demetrius H. Bagley and Kelly A. Healy -- 26. Endourologic Management of Non-Malignant Bilharzial Urinary Complications / Hamdy Mohamed Ibrahim, Ahmad Samy Bedair, and Ahmed M. Al-Kandari -- 27. Ureteroscopy During Pregnancy / Hamdy Mohamed Ibrahim and Ahmed M. Al-Kandari -- 28. Pediatric Percutaneous Nephrolithotomy (PCNL): Overcoming the Difficulties / Sinan Zeren and Hakan Çakir -- 29. Pediatric Ureteroscopy: Overcoming the Difficulties / Raguram Ganesamoni, Shashikant Mishra, and Mahesh Desai -- 30. Difficulties with Ureteral Stents / Brandon K. Isariyawongse and Manoj Monga -- 31. Overcoming the Cost Difficulties in Endourology / Ravindra B. Sabnis -- 32. Difficulties in Endourologic Training / Ahmed M. Al-Kandari -- 33. Avoiding and Overcoming Medico-Legal Difficulties in Endourology / Donnaline Richman and James H. Robb.
  • 2011 Springer
    Al-Kandari, Ahmed M.; Gill, Inderbir S.
    Difficulties in Laparoscopic Access -- Difficulties in Anesthesia for Urologic Laparoscopy -- Difficulties in Urologic Laparoscopic Instrumentation -- Cost-Reductive Measures in Laparoscopy: Tips and Tricks for Developing Countries -- Difficulties in Laparoscopic Simple Nephrectomy -- Difficulties in Transperitoneal Laparoscopic Radical Nephrectomy -- Difficulties in Retroperitoneal Laparoscopic Radical Nephrectomy -- Difficulties in Laparoscopic Live Donor Nephrectomy -- Difficulties in Laparoscopic Nephroureterectomy -- Difficulties in Laparoscopic Partial Nephrectomy -- Difficulties in Laparoscopic Adrenalectomy -- Difficulties in Laparoscopic Renal Cyst Removal and Giant Hydronephrosis Nephrectomy -- Difficulties in Laparoscopic Simple Prostatectomy -- Difficulties in Laparoscopic Radical Prostatectomy -- Difficulties in Robotic Radical Prostatectomy -- Difficulties in Robotic-Assisted Nerve-Sparing Radical Prostatectomy -- Difficulties in Laparoscopic Urologic Surgery in Kidney Transplant Patients and Obese Patients -- Difficulties in Laparoscopic Retroperitoneal Lymph Node Dissection -- Difficulties in Laparoscopic Radical Cystectomy -- Difficulties in Laparoscopic Pyeloplasty -- Difficulties in Laparoscopic Surgery for Urinary Stones -- Difficulties in Laparoscopic Ureteral and Bladder Reconstruction -- Difficulties in Laparoscopic Ureterolysis and Retroperitoneal Lymph Node Dissection -- Difficulties in Laparoscopic Management of Vesicovaginal Fistula -- Difficulties in the Laparoscopic Treatment of Female Genital Prolapse -- Difficulties in Pediatric Laparoscopic Urologic Surgery -- Difficulties in Single-Port Laparoscopic Procedures -- Difficulties in Urologic Laparoscopy Complications -- Difficulties in Laparoscopic Training, Mentoring, and Medico-Legal Issues.
  • 2011 Springer
    Ferguson, Mark K.
  • 2007 Springer
    Ferguson, Mark K.
  • 2014 Springer
    Ferguson, Mark K.
    Introduction -- Evidence Based Medicine: Quality of Evidence and Evaluation Systems -- Decision Analytic Techniques and Other Decision Processes -- Decision Making: The Surgeon's Perspective -- Decision Making: The Patient's Perspective -- Indications for Pretreatment Pathologic Mediastinal Staging in Non-small Cell Lung Cancer -- Preoperative Smoking Cessation for Lung Resection Patients -- High Tech Exercise Testing in Assessing Candidates for Lung Resection -- Management of Perioperative Anticoagulation in Lung Resection -- Perioperative Arrhythmia Prophylaxis for Major Lung Resection -- VATS Versus Open Lobectomy for Stage I or II NSCLC -- Robotic-Assisted Thoracoscopic Surgery (RATS) Versus Video-Assisted Thoracoscopic Surgery (VATS) Lobectomy for Stage I or II Non-small Cell Lung Cancer -- Lobectomy After Induction Therapy for NSCLC in the Presence of Persistent N2 Disease -- Pneumonectomy After Induction Therapy for Non-small Cell Lung Cancer -- Resection Versus SBRT for Stage I Non-small Cell Lung Cancer in Patients with Good Pulmonary Function -- Digital Drainage Systems After Major Lung Resection -- Management of Persistent Post-operative Alveolar Air Leak -- Surveillance After Resection of Stage I Non Small Cell Lung Cancer -- Support Therapy for Lung Failure: The Utility of Device Therapy -- Extracorporeal Support for Lung Grafts Prior to Transplantation -- Pulmonary Metastasectomy -- Optimal Therapy for Barrett High Grade Dysplasia -- Preoperative Chemo Versus Chemoradiotherapy for Regionally Advanced Esophageal Adenocarcinoma -- The Role of Surgery in the Management of Regionally Advanced Esophageal Squamous Cell Cancer -- Optimal Surgical Approach to Esophagectomy for Distal Esophageal Adenocarcinoma -- Regional Extent of Lymphadenectomy for Esophageal Cancer -- Optimal Lymph Node Dissection in Esophageal Cancer -- Salvage Esophagectomy for Persistent or Recurrent Disease After Definitive Chemoradiotherapy -- Gastric Emptying Procedure After Esophagectomy -- Postoperative Adjuvant Therapy After Resection of Regionally Advanced Esophageal Cancer -- Prophylactic Antireflux Surgery in Lung Transplantation -- Surgical Versus Endoscopic Management for Esophageal Perforations -- Stents for Esophageal Anastomotic Leak -- Management of Small Esophageal GIST Tumors -- Surgery for Minimally Symptomatic Pulsion Diverticula of the Thoracic Esophagus -- Partial Versus Total Fundoplication for GERD in Patients with Normal Esophageal Motility -- Diaphragm Pacing -- Minimally Invasive Versus Open Repair of Giant Paraesophageal Hernia -- Synthetic Reinforcement of Diaphragm Closure for Large Hiatal Hernia Repair -- Diaphragmatic Plication for Eventration -- Management of Minimally Symptomatic Recurrent Hiatal Hernia -- Stenting for Benign Airway Obstruction -- Bioengineered Tissues for Tracheal Reconstruction -- Percutaneous Versus Standard Tracheostomy in the Critically Ill Adult -- Carinal Resection for Non Small Cell Lung Cancer -- Management of Persistent Postoperative Air Leaks -- Fibrinolytics for Managing Pleural Empyema -- VATS Versus Open Management of Pleural Empyema -- Optimal Management of Symptomatic Malignant Pleural Effusion -- Pleurectomy Versus Radical Pleuropneumonectomy for Malignant Pleural Mesothelioma -- Surgical and Medical Therapy for Malignant Pleural Mesothelioma -- Extended Versus Standard Thymectomy for Myasthenia Gravis -- Optimal Approach for Resection of Encapsulated Thymoma: Open Versus VATS -- Robotic Versus VATS Thymectomy for Encapsulated Thymoma -- Video Mediastinoscopy Versus Standard Mediastinoscopy -- Debulking for Extensive Thymoma -- Surgery for Palmar Hyperhidrosis: Patient Selection and Extent of Surgery -- Synthetic Versus Biologic Reconstruction of Bony Chest Wall Defects -- Management of Flail Chest -- Management of Pectus Deformities in Adults.
  • 2014 Springer
    Delgado, Sergio V.; Strawn, Jeffrey R.
    This innovative and important book describes a practical and clinically-relevant approach to the 'difficult' psychiatric consultation. The authors systematically examine psychodynamic theories, family systems theories, and legal and ethical aspects of these consultations. Difficult Psychiatric Consultations: An Integrated Approach is unique compared to most psychiatric texts, in that it weaves traditional concepts in understanding a person and their family with contemporary developmental and relational concepts. The importance of these concepts, when applied to the study of the complexities and the interplay between patients, treatment teams and patients' families in today's medical centers, is brought to life through rich, real-life clinical examples. These powerful clinical vignettes allow the reader to put himself in the psychiatric consultant's shoes as he navigates practical interventions to improve the outcomes of 'difficult' consultations. To that end, the authors provide tables to outline pre and post diagnosis observable patterns of the parties involved in the psychiatric consultation. This book has much to offer to general psychiatrists, child and adolescent psychiatrists, psychiatric residents, psychologists, nurse practitioners and social workers.
  • pt. A-B, 1985. ScienceDirect
    pt. B ScienceDirect
    Hirs, C. H. W.; Timasheff, Serge N.; Wyckoff, Harold W.
    Also available: Print – pt. A-B, 1985.
  • 2013 Springer
    Duffau, Hugues.
    The biology, behavior and management of diffuse low-grade gliomas (DLGG) in adults have been matters of controversy for many decades. However, recent technical and conceptual advances in genetics, imaging and treatments have paved the way towards individualized management. In addition, advancing knowledge of brain processing means that it is possible to take into consideration the interaction between the disease (low-grade glioma) and the host (the brain) and thus to modulate the therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life. Diffuse Low-Grade Gliomas in Adults: Natural History, Interaction with the Brain, and New Individualized Therapeutic Strategies presents the latest research pertaining to the diagnosis, therapy and management of diffuse low-grade gliomas (DLGG) in adults, with a particular focus on the path towards individualized therapy for this kind of tumor. Recent research on the natural history of DLGGs and their interaction with the brain has led to new diagnostic and therapeutic strategies which increase survival and quality of life of the patient, and these methods are described in this book. This book uniquely focuses on addressing diffuse low-grade gliomas in adults and is a valuable resource for medical oncologists, neuro-oncologists and neurologists.
  • 2012 Springer
    Baughman, Robert P.; Du Bois, Roland M.
    Section I. General Considerations -- 1. Patient Evaluation / Keith C. Meyer and Ganesh Raghu -- 2. Radiologic Evaluation / David A. Lynch -- 3. Bronchoalveolar Lavage / Marjolein Drent and Catharina F.M. Linssen -- 4. Pathology of Diffuse Lung Disease / Thomas V. Colby and Kevin O. Leslie -- 5. Pulmonary Function Testing / Athol U. Wells, Simon Ward, and Derek Cramer -- 6. Diffuse Lung Disease: Classification and Evaluation / Harold R. Collard and Talmadge E. King Jr. -- 7. Drug Therapy for Interstitial Lung Disease / Robert P. Baughman, Ulrich Costabel, and Elyse E. Lower -- 8. Pulmonary Hypertension in Interstitial Lung Disease / Oksana A. Shlobin and Steven D. Nathan -- Section II. Specific Diseases -- 9. Sarcoidosis / Daniel A. Culver and Marc A. Judson -- 10. Idiopathic Pulmonary Fibrosis / Joseph P. Lynch III and John A. Belperio -- 11. Nonspecific Interstitial Pneumonia / Kevin R. Flaherty and Fernando J. Martinez -- 12. A Practical Approach to Connective Tissue -- Disease-Associated Lung Disease / Aryeh Fischer and Roland M. du Bois -- 13. Hypersensitivity Pneumonitis: A Clinical Perspective / Moisés Selman, Mayra Mejía, Héctor Ortega, and Carmen Navarro -- 14. Smoking and Interstitial Lung Disease / Joshua J. Solomon and Kevin K. Brown -- 15. Childhood Interstitial Lung Disease / Lisa R. Young -- 16. Rare Interstitial Lung Diseases / Tristan J. Huie, Amy L. Olson, Marvin I. Schwarz, and Stephen K. Frankel -- 17. Occupational- and Drug-Induced Disorders / Michal Pirozynski and John Joseph Borg -- 18. Bronchiolitis / Vincent Cottin and Jean-François Cordier -- 19. Pulmonary Vasculitis / Ulrich Specks and Karina A. Keogh.
  • 2006 Springer
    Dalpiaz, Giorgia; Maffessanti, Mario.
  • 2015 Springer
    Allen, Timothy C.
    This volume is the most up-to-date text available on diffuse malignant mesothelioma and includes all the newest imaging modalities, immunohistochemical features, and ever-expanding information on the molecular characteristics of the cancer. In-depth chapters contain fully referenced text as well as detailed tables and images. While the primary audiences for this book are pathologists and pathology residents, the broad examination of diffuse malignant mesothelioma, including its epidemiology, makes this book valuable to radiologists, surgeons, oncologists, and other clinical physicians and their residents as well. Written by experts in the field, Diffuse Malignant Mesothelioma is a concise yet comprehensive resource for clinicians involved in the management of one of the most widely recognized and feared cancers in the world.
  • 2007 Karger
    Costabel, Ulrich; Du Bois, Roland M.; Egan, Jim J.
  • 2009 ScienceDirect
    Behrens, Timothy E. J.; Johansen-Berg, Heidi.
    Introduction to diffusion MRI -- Introduction to diffusion MR -- Pulse sequences for diffusion-weighted MRI -- Gaussian modeling of the diffusion signal -- Multiple fibers : beyond the diffusion tensor -- Diffusion MRI for quantitative measurement -- White matter structure : a microscopist's view -- Biological basis of diffusion anisotropy -- Inferring microstructural information of white matter from diffusion MRI -- Cross-subject comparison of local diffusion MRI parameters -- Diffusion MRI in neurological disorders -- DTI in development and aging -- Individual differences in white matter microstructure in the healthy brain -- Diffusion tensor imaging and its application to schizophrenia and related disorders -- Diffusion MRI for in vivo neuroanatomy -- Classic and contemporary neural tract tracing techniques -- Human connectome: linking structure and function in the human brain -- MR diffusion tractography -- Validation of tractography -- Connectivity fingerprinting of gray matter -- Connectional anatomy of language: recent contributions from diffusion tensor tractography -- Tractography for surgical targeting -- Comparing brain connections in differenct species using diffusion weighted imaging -- Imaging structure and function.
  • 2011
    Jones, Derek K.
    PrintStatus: Not Checked OutLane Catalog Record
    The functional anatomy of white matter: from postmortem dissections to in vivo virtual tractography / Marco Catani -- Neurobiology of white matter disorders / Christopher M. Filley -- Invasive methods for tracing white matter architecture / Hubertus Axer -- Physics of diffusion / Paul T. Callaghan -- Magnetic resonance diffusion imaging: introduction and concepts / Denis Le Bihan -- Anisoptropic diffusion: from the apparent diffusion coefficient to the apparent diffusion tensor / Peter J. Basser and Evren Özarslan -- What makes diffusion anisotropic in the nervous system? / Christian Beaulieu -- Biophysics of diffusion in cells / Joseph J.H. Ackerman and Jeffrey J. Neil -- Extracting geometric properties of white matter with q-Space Diffusion MRI (QSI) / Yaniv Assaf and Yoram Cohen -- The cumulant expansion: an overarching mathematical framework for understanding diffusion NMR / Valerij G. Kiselev -- Hardware considerations for diffusion MRI / Nirbhay N. Yadav, Tim Stait-Gardner, and William S. Price -- EPI-based pulse sequences for diffusion tensor MRI / Stefan T. Skare and Roland Bammer -- Non-EPI pulse sequences for diffusion MRI / James G. Pipe -- Phase errors in diffusion-weighted imaging / Roland Bammer ... [et al.] -- Optimal approaches to diffusion MRI acquisition / Derek K. Jones -- Least squares approaches to diffusion tensor estimation / Cheng Guan Koay -- Image distortion and its correction in diffusion MRI / Jesper J.L. Andersson and Stefan T. Skare -- Artifacts in diffusion MRI / Carlo Pierpaoli -- Quality assurance for diffusion MRI / Nicholas G. Dowell and Paul S. Tofts -- Statistical issues in diffusion tensor MRI / Sinisa Pajevic -- Visualization of diffusion MRI data / Alexander Leemans -- Deterministic white matter tractography / Andrew L. Alexander -- Probabilistic fiber tracking / Geoff J.M. Parker -- Connectivity-based parcellation of gray matter / Timothy Behrens ... [et al.] -- Diffusion tensor microimaging and its applications / Jiangyang Zhang ... [et al.] -- Anatomical validation of DTI and tractography / I. Nigel C. Lawes and Christopher A. Clark -- Mathematics of crossing fibers / Daniel Alexander and Kiran K. Seunarine ; The biophysics of crossing fibers / Jacques-Donald Tournier -- Strategies for patient-control comparison of diffusion MR data / Mara Cercignani -- Diffusion tensor MRI in brain development / Petra Hüppi -- Diffusion in acute stroke / Ona Wu ... [et al.] -- Diffusion in chronic stroke and small vessel disease / Michael O'Sullivan -- Diffusion imaging in brain tumors / Aaron S. Field -- Diffusion tensor MRI in multiple sclerosis / Massimo Filippi and Maria A. Rocca -- Diffusion MRI in epilepsy / Khalid Hamandi and Robert Powell -- DTI and tractography in neurosurgical planning / Christopher A. Clark and Tiernan Byrnes -- Diffusion MRI in psychiatric disorders / Tonya White and Kelvin O. Lim -- Diffusion tensor imaging in aging and age-related neurodegenerative disorders / Edith V. Sullivan and Adolf Pfefferbaum -- Diffusion imaging in gray matter / Helen D'Arceuil and Alex de Crespigny -- Diffusion imaging in the optic nerve, spinal cord, and peripheral nerve / Claudia A.M. Wheeler-Kingshott and Olga Ciccarelli -- Diffusion imaging in muscle / Gustav J. Strijkers, Maarten R. Drost, and Klaas Nicolay -- Insights into diffusion tensor imaging from animal models of white matter pathology / Matthew D. Budde and Sheng-Kwei Song -- Reminiscences about the development of Pulsed Field Gradient Spin Echo NMR (PFGSE-NMR) / Ed O. Stejskal and John E. Tanner -- Diffusion, diffraction, and microimaging / Paul T. Callaghan -- Diffusion MRI: conception, birth, and adolescence / Denis Le Bihan -- DWI in cerebral ischemia: the early days / Michael E. Moseley -- Invention and development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH / Peter J. Basser.
  • 2012 Springer
    Luna, A.; Ribes, Ramón; Soto, Jorge A.
    1. Diffusion-Weighted Imaging: Acquisition and Biophysical Basis / Javier Sánchez-González and Javier Lafuente-Martínez -- 2. How to Identify and Avoid Artifacts on DWI / Javier Sánchez-González -- 3. Quantification and Postprocessing of DWI / Javier Sánchez-González and Antonio Luna -- 4. DWI at 3 T: Advantages, Disadvantages, Pitfalls, and Advanced Clinical Applications / Javier Sánchez-González and Antonio Luna -- 5. DWI of the Liver / Antonio Luna and Luis Luna -- 6. Diffusion-Weighted MR Imaging of the Pancreas / Jorge A. Soto, German A. Castrillon, Stephan Anderson, and Nagaraj Holalkere -- 7. Diffusion-Weighted MR Imaging of the Renal and Adrenal Glands / Nagaraj Holalkere, Stephan Anderson, and Jorge A. Soto -- 8. Diffusion-Weighted Imaging of Prostate, Bladder, and Retroperitoneum / Joan C. Vilanova, Roberto García-Figueiras, Joaquim Barceló, and Antonio Luna -- 9. Use of DWI in Female Pelvis / German A. Castrillon, Stephan Anderson, Nagaraj Holalkere, and Jorge A. Soto -- 10. DWI of the Breast / Joaquim Barceló, Joan C. Vilanova, and Antonio Luna -- 11. Diffusion-Weighted Imaging of the Gastrointestinal Tract and Peritoneum / German A. Castrillon, Stephan Anderson, Jorge A. Soto, and Antonio Luna -- 12. Diffusion-Weighted Imaging of Anorectal Region / Lidia Alcalá, Teodoro Martín, and Antonio Luna -- 13. Diffusion-Weighted Imaging in the Evaluation of Lung, Mediastinum, Heart, and Chest Wall / Antonio Luna, Teodoro Martín, and Javier Sánchez González -- 14. Role of DWI in the Evaluation of Tumors of the Head and Neck and in the Assessment of Lymph Nodes / Inmaculada Rodriguez, Teodoro Martín, and Antonio Luna -- 15. Musculoskeletal Applications of DWI / Joan C. Vilanova, Sandra Baleato, and Elda Balliu -- 16. Whole-Body Applications of DWI / Joan C. Vilanova, Sandra Baleato, Joaquim Barceló, and Antonio Luna.
  • 2013 Springer
    Stieltjes, Bram.
    Diffusion Tensor Imaging (DTI) is a variation of diffusion-weighed imaging. Particularly in the neurosciences, this technique has gained tremendous momentum in the past decade, both from a technical point of view as well as in its applications. DTI is mainly used in neurological diagnosis and psychiatric and neurologic research, e.g. in order to locate brain tumors and depict their invasivity. DTI offers a unique in-vivo insight into the three-dimensional structure of the human central nervous system. While easy interpretation and evaluation is often hampered by the complexity of both the technique and neuroanatomy, this atlas helps you recognize every one of the important structures rapidly and unambiguously.In the introduction, this atlas provides a concise outline of the evolution of diffusion imaging and describes its potential applications. In the core part of the atlas, the neuroanatomically important structures are clearly labeled both on DTI-derived color maps and conventional MRI. Complex fiber architecture is illustrated schematically and described concisely in textboxes directly on the relevant page. In the final part of the atlas, a straightforward, step-by-step approach for the three-dimensional reconstruction of the most prominent fiber structures is given, and potential pitfalls are indicated.The atlas aims at neuroscientists, neuroanatomists, neurologists, psychiatrists, clinical psychologists, physicists, and computer scientists. For advanced users, the atlas may serve as a reference work, while students and scientists are thoroughly introduced into DTI.
  • 2005 Springer
    Moritani, T.
  • 2009 Springer
    Moritani, T.; Ekholm, S.; Westesson, Per-Lennart.
  • 2013
    Eroschenko, Victor P.; Fiore, Mariano S. H. di.
    PrintStatus: Not Checked OutLane Catalog Record
    Histologic methods -- Light and transmission electron microscopy -- Cells and the cell cycle -- Epithelial tissue -- Connective tissue -- Hematopoietic tissue -- Skeletal tissue : cartilage and bone -- Muscle tissue -- Nervous tissue -- Circulatory system -- Immune system -- Integumentary system -- Digestive system part I : oral cavity and major salivary glands -- Digestive system part II : esophagus and stomach -- Digestive system part III : small and large intestines -- Digestive system part IV : accessory digestive organs -- Respiratory system -- Urinary system -- Endocrine system -- Male reproductive system -- Female reproductive system -- Organs of special senses : visual and auditory systems.
  • 2008
    Eroschenko, Victor P.; Fiore, Mariano S. H. di.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 Springer
    Fried, Bernard; Toledo, Rafael.
    Part 1. General aspects of trematodes. Form and function in the Digenea / Robert C. Peoples and Bernard Fried -- The systemics of the Trematoda / Aneta Kostadinova and Ana Pérez-del-Olmo -- part 2. Trematodes of interest in human health. Schistosomiasis / Fred A. Lewis and Matthew S. Tucker -- Fascioliasis / Santiago Mas-Coma, M. Adela Valerno and M. Dolores Bargues -- Paragonimiasis / David Blair -- Liver flukes: Clonorchis and Opisthorchis / Weerachai Saijuntha, Paiboon Sithithaworn, Nadda Kaitsopit, Ross H. Andrews, and Trevor N. Petney -- Intestinal trematode infections / Rafael Toledo, Carla Muñoz-Antoli, and J. Guillermo Esteban -- Epidemiology of trematode infections / Jong-Yil Chai -- Diagnosis of human trematode infections / J. Guillermo Esteban, Carla Muñoz-Antoli, Rafael Toledo, and Lawrence R. Ash -- part 3. Trematodes of interest in veterinary and wildlife disease. Schistosomatoidea and Diplostomoidea / Petr Horák, Libuš Kolá̌řová, and Libor Mikeš -- Amphistomes / Veena Tandon, Bishnupada Roy, Jollin Andrea Shylla -- Dicrocoeliidae family: major species causing veterinary diseases / M. Yolanda Manga-González and M. Carmen Ferreras -- Selected wildlife trematodiasis / Jane E. Huffman -- Index.
    Also available: Print – 2014
  • 2008 ScienceDirect
    Font, Josep; Ramos-Casals, Manuel; Rodés, Joan.
    The book "The digestive system in systemic autoimmune diseases" represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. The volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico and South Africa share their knowledge in this detailed volume. *One book of leading international clinical and scientific experts on autoimmune and digestive diseases. *A practical guide to the identification, diagnosis and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties. *Several diseases and conditions not included in other text books are included, some of which are of recent emergence. *Each chapter is designed to serve as a Guide to Clinical Practice for each disease.
  • 2009 Springer
    Finn, Nancy B.; Bria, William F.
  • 2015
    Wachter, Robert M.
    PrintStatus: Not Checked OutLane Catalog Record
    For the past few decades, technology has been touted as the cure for all of healthcare's ills, yet medicine stubbornly resisted computerization-- until now. Thanks largely to billions of dollars in federal incentives, healthcare has finally gone digital. Wachter examines healthcare at the dawn of its computer age, and shows how technology is changing care at the bedside. He questions whether government intervention has been useful or destructive-- and does so with clarity, insight, humor, and compassion.
  • 2014 Atypon
    Oloumi, Faraz; Ells, Anna L.; Rangayyan, Rangaraj M.
    The monitoring of the effects of retinopathy on the visual system can be assisted by analyzing the vascular architecture of the retina. This book presents methods based on Gabor filters to detect blood vessels in fundus images of the retina. Forty images of the retina from the Digital Retinal Images for Vessel Extraction (DRIVE) database were used to evaluate the performance of the methods. The results demonstrate high efficiency in the detection of blood vessels with an area under the receiver operating characteristic curve of 0:96. Monitoring the openness of the major temporal arcade (MTA) could facilitate improved diagnosis and optimized treatment of retinopathy. This book presents methods for the detection and modeling of the MTA, including the generalized Hough transform to detect parabolic forms. Results obtained with 40 images of the DRIVE database, compared with hand-drawn traces of the MTA, indicate a mean distance to the closest point of about 0:24 mm. This book illustrates applications of the methods mentioned above for the analysis of the effects of proliferative diabetic retinopathy and retinopathy of prematurity on retinal vascular architecture.
  • 2011 Atypon
    Zhu, Xiaolu; Ells, Anna L.; Rangayyan, Rangaraj M.
    Fundus images of the retina are color images of the eye taken by specially designed digital cameras. Ophthalmologists rely on fundus images to diagnose various diseases that affect the eye, such as diabetic retinopathy and retinopathy of prematurity. A crucial preliminary step in the analysis of retinal images is the identification and localization of important anatomical structures, such as the optic nerve head (ONH), the macula, and the major vascular arcades. Identification of the ONH is an important initial step in the detection and analysis of the anatomical structures and pathological features in the retina. Different types of retinal pathology may be detected and analyzed via the application of appropriately designed techniques of digital image processing and pattern recognition. Computer-aided analysis of retinal images has the potential to facilitate quantitative and objective analysis of retinal lesions and abnormalities. Accurate identification and localization of retinal features and lesions could contribute to improved diagnosis, treatment, and management of retinopathy.
  • 2005 Springer
    Jähne, Bernd.
  • 2014 Springer
    Pianykh, Oleg S.
    Making a good diagnostic image is only the beginning; keeping it good and diagnostically sound is a much more difficult proposition, one that is often neglected or forgotten by clinical practitioners. With anything digital, the assumption of persistent original quality opens a Pandora's box of medical fiascos. Poorly selected image interpolation, thoughtlessly used compression, confused image enhancement options and the like can transform a good original into a useless clutter of pixels. This book is dedicated to learning better options.
  • 2005 CRCnetBASE
    Reed, Todd Randall.
  • 2012 Springer
    Pianykh, Oleg S.
    Part I. Introduction to DICOM -- 1. What Is DICOM? -- 2. How does DICOM work? 3. Where do you get DICOM from? -- Part II. DICOM and clinical data -- 4. A brief history of DICOM -- 5. Parlez-vous DICOM? 6. Medical images in DICOM -- Part III. DICOM comunications -- 7. DICOM SOPs: Basic 8. DICOM SOPs: Beyond basic -- 9. DICOM associations -- Part IV: DICOM media and security -- 10. DICOM media: files, folders, and DICOMDIRs -- 11. DICOM security -- 12. Incompatibility of compatible -- Part V. Advanced topics -- 13. DICOM and teleradiology -- 14. Standards and system integration in digital medicine -- 15. Disaster PACS planning and management -- 16. DICOM applications: usual and not -- 17. DICOM software development -- 18. DICOM implementation plans -- 19. DICOM FAQs.
  • 2008 Springer
    Pianykh, Oleg S.
  • 2013 Springer
    Lanca, Luís; Silva, Augusto.
  • 2010 Springer
    Bick, U.; Diekmann, F.
  • 2015 Springer
    Hogg, Peter.
    This up-to-date, evidence-based book covers the whole range of mammography and mammography-related techniques used in practice, and also the rapid and increasingly sophisticated evolution of mammographic clinical practice and technology.A wide range of topics, from the psychological and emotional support required from the practitioner to all aspects of screening and symptomatic mammographic imaging, are discussed. Digital Mammography: A Holistic Approach is aimed at radiographers, technicians, technologists, physicists, nurses and medical practitioners worldwide, and enables the reader to gain a better understanding of techniques, equipment and anatomy.
  • 2008 Springer
    Krupinski, Elizabeth A.
  • 2007 CRCnetBASE
    Chakrabarty, Krishnendu; Su, Fei.
  • 2007 ScienceDirect
    Sluder, Greenfield; Wolf, D. E.
    Also available: Print – 2007
  • 2013 ScienceDirect
    Sluder, Greenfield; Wolf, D. E.
  • 2011
    Saria, Suchi; Koller, Daphne; Penn, Anna Asher; Thrun, Sebastian.
    The current unprecedented rate of digitization of longitudinal health data --- continuous device monitoring data, laboratory measurements, medication orders, treatment reports, reports of physician assessments --- allows visibility into patient health at increasing levels of detail. A clearer lens into this data could help improve decision making both for individual physicians on the front lines of care, and for policy makers setting national direction. However, this type of data is high-dimensional (an infant with no prior clinical history can have more than 1000 different measurements in the ICU), highly unstructured (the measurements occur irregularly, and different numbers and types of measurements are taken for different patients) and heterogeneous (from ultrasound assessments to lab tests to continuous monitor data). Furthermore, the data is often sparse, systematically not present, and the underlying system is non-stationary. Extracting the full value of the existing data requires novel approaches. In this thesis, we develop novel methods to show how longitudinal health data contained in Electronic Health Records (EHRs) can be harnessed for making novel clinical discoveries. For this, one requires access to patient outcome data --- which patient has which complications. We present a method for automated extraction of patient outcomes from EHR data; our method shows how natural languages cues from the physicians notes can be combined with clinical events that occur during a patient's length of stay in the hospital to extract significantly higher quality annotations than previous state-of-the-art systems. We develop novel methods for exploratory analysis and structure discovery in bedside monitor data. This data forms the bulk of the data collected on any patient yet, it is not utilized in any substantive way post collection. We present methods to discover recurring shape and dynamic signatures in this data. While we primarily focus on clinical time series, our methods also generalize to other continuous-valued time series data. Our analysis of the bedside monitor data led us to a novel use of this data for risk prediction in infants. Using features automatically extracted from physiologic signals collected in the first 3 hours of life, we develop Physiscore, a tool that predicts infants at risk for major complications downstream. Physiscore is both fully automated and significantly more accurate than the current standard of care. It can be used for resource optimization within a NICU, managing infant transport to a higher level of care and parental counseling. Overall, this thesis illustrates how the use of machine learning for analyzing these large scale digital patient data repositories can yield new clinical discoveries and potentially useful tools for improving patient care.
  • 2005 Wiley
    Rangarao, Kaluri Venkata; Mallik, Ranjan K.
    Chapter 1. Processing of Signals, p. 1-20 -- Chapter 2. Revisiting the Basics, p. 21-44 -- Chapter 3. Digital Filters, p. 45-78 -- Chapter 4. Fourier Transform and Signal Spectrum, p. 79-100 -- Chapter 5. Realisation of Digital Filters, p. 101-119 -- Chapter 6. Case Studies, p. 121-128 -- Appendix. MATLAB and C Programs, p. 129-185.
  • 2005 CRCnetBASE
    Kumar, B. Preetham.
  • Miller, Carolyn Handler.
  • 2012 Springer
    Cuadros, Jorge; Goldschmidt, Leonard Paul; Yogesan, Kanagasingam.
    Digital retinal imaging performed by primary care providers and nurses, followed by remote image interpretation (teleretinal imaging), is rapidly acquiring a crucial role in many parts of the world as it permits the detection of major diseases, such as diabetic retinopathy and glaucoma, in patients who would otherwise be beyond the reach of a trained ophthalmologist. In this book, experts from around the world describe how digital teleretinal screening can be set up and optimally utilized. Technical issues are discussed, and the appropriate use of screening for different diseases and in different age groups is explained. The major part of the book draws upon the clinical experience of leading practitioners in a wide range of teleretinal applications. The result is a comprehensive source of high-quality information for clinicians and other health professionals who are involved in eye care delivery, so that they can assess how teleretinal screening might be applied to their working practice.
  • 2012
    Jacobson, Nora.
    PrintStatus: Not Checked OutLane Catalog Record
    In these hard times of global financial peril and growing social inequality, injuries to dignity are pervasive. "Indignity has many faces," one man told Nora Jacobson as she conducted interviews for this book. Its expressions range from rudeness, indifference, and condescension to objectification, discrimination, and exploitation. Yet dignity can also be promoted. Another man described it as "common respect," suggesting dignity's ordinariness, and the ways we can create and share it through practices like courtesy, leveling, and contribution. Dignity and Health examines the processes and structures of dignity violation and promotion, traces their consequences for individual and collective health, and uses the model developed to imagine how we might reform our systems of health and social care. With its focus on the dignity experiences of those often excluded from the mainstream--people who are poor, or homeless, or dealing with mental health problems--as well as on vulnerabilities like age or sickness or unemployment that threaten to make us all feel "less than," Dignity and Health recognizes dignity as a moral matter embedded in the choices we make every day.
  • 2008 Springer
    Bolognesi, Martino; Di Prisco, Guido; Verde, Cinzia.
    Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments. This book is dedicated to Jonathana (TM)s and Beaa (TM)s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
  • 2006 Springer
    Bank, Ute; Lendeckel, Uwe; Reinhold, Dirk.
    Topic I. Structure and function. Peptide substrates of dipeptidyl peptidases / Inger Brandt ... [et al.] Phosphorus-containing inhibitors of proteolytic enzymes / Angel Stöckel-Maschek ... [et al.] Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8 / Xin Chen. Prediction of dipeptidyl peptidase (DP) 8 structure by homology modelling / Melissa R. Pitman, R. Ian Menz, and Catherine A. Abbott -- Topic II. DPIV-related enzymes. Structure and function in dipeptidyl peptidase IV and related proteins / Mark D. Gorrell ... [et al.] Expression and function of dipeptidyl peptidase IV and related enzymes in cancer / Petr Busek ... [et al.] DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration, and apoptosis / Denise M.T. Yu ... [et al.] In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII / Marie-Berthe Maes ... [et al.] Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells / Sabine Wrenger ... [et al.] Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities / Joohong Park ... [et al.] Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits and unknown post-cysteine cleavage specificity / Joachim Wolfgang Bär ... [et al.] Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR / Leona Wagner ... [et al.] -- Topic III. Metabolic disorders. Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM) / Simon A. Hinke, Raymond A. Pederson, and Christopher H.S. McIntosh. Dipeptidyl peptidase IV: a molecular switch of vascular actions of neuropeptide Y / Lijun Li, Hans-Ulrich Demuth, and Zofia Zukowska -- Topic IV. Immune disorders. Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases: proof of concept in a mouse model of colitis / Ute Bank ... [et al.] Dipeptidyl peptidases and inflammatory bowel disease / Catherine A. Abbott ... [et al.] Possible role of DP IV inhibitors in acne therapy / Anja Thielitz ... [et al.] Dipeptidyl peptidase-IV activity and/or structure homologs (DASH): contributing factors in the pathogenesis of rheumatic diseases? / Eva Balaziova ... [et al.] -- Topic V. Neuronal diseases. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation / Aliza Biton ... [et al.] CD26/DP IV in T cell activation and autoimmunity / Vera Preller ... [et al.] DPIV/CD26 and FAP in cancer: a tale of contradictions / Melanie L. Sulda, Catherine A. Abbott, and Martin Hildebrandt. Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells / Monica Salamone ... [et al.] Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin / Xin M. Wang ... [et al.] Role of neuropeptide Y and dipeptidyl peptidase IV in regulation of Ewing's sarcoma growth / Joanna Kitlinska ... [et al.] The role of CD26/DPP IV in preservation of early pulmonary graft function / Florian Johannes Jung ... [et al.].
    Also available: Print – 2006
  • 2011 Springer
    Roeder, Larry W.
    Diplomatic theory and practice -- International funding for animal protection -- International conferences and delegation management -- The media as a tool for diplomacy -- Important associations and international organizations -- Epilogue
  • 2013
    Tilmans, Nicolas; Brown, Patrick O.; Harbury, Pehr A. B.; Khosla, Chaitan.
    Directed evolution of large combinatorial chemistry libraries is an emerging approach for small-molecule discovery. To advance this field, we have developed a DNA-programmed chemistry technique that enables breeding of drug-like compounds over multiple generations. The progeny from each cycle of synthesis, selection, and amplification act as the starting point for a subsequent generation; thus the evolutionary cycle can be iterated. The linkage between genotype and phenotype is accomplished by coupling each unique compound to a DNA gene that programs its synthesis. Here we establish the behavior of our technology using a model selection for kinase substrates. We show that the platform behaves in a predictable manner and that it should be capable of identifying useful molecules from very large compound libraries. We then use the technology to discover novel biologically active small molecules by applying a purifying selection to a naive DNA-programmed library comprising 1.1 billion distinct compounds. Given the comprehensive nature of the combinatorial synthesis and the deep sampling enabled by high throughput sequencing, we can observe the simultaneous enrichment of different chemical families, increasing our chances of identifying a true hit. We have thus identified the first known non-peptidic substrate for protein kinase. This work demonstrates the feasibility to chemically probe the substrate binding sites of kinases. More broadly, we have performed the first directed evolution of a billion member combinatorial library. We anticipate that our approach will lead to the discovery of novel small-molecule affinity reagents, pharmaceutical compound leads, imaging probes and other high-value compounds. This could substantially increase global access to small-molecule reagents, and open up new areas of biological inquiry.
  • 2002 Wiley
    Brakmann, Susanne; Johnsson, Kai.
    ch. 1. Introduction, p. 1-3 / Kai Johnsson and Susanne Brakmann, p. 1-3 -- ch. 2. Evolutionary Biotechnology - From Ideas and Concepts to Experiments and Computer Simulations / Peter Schuster, p. 5-28 -- ch. 3. Using Evolutionary Strategies to Investigate the Structure and Function of Chorismate Mutases / Donald Hilvert, Sean V. Taylor and Peter Kast, p. 29-62 -- ch. 4. Construction of Environmental Libraries for Functional Screening of Enzyme Activity / Rolf Daniel, p. 63-78 -- ch. 5. Investigation of Phage Display for the Directed Evolution of Enzymes / Patrice Soumillion and Jacques Fastrez, p. 79-110 -- ch. 6. Directed Evolution of Binding Proteins by Cell Surface Display: Analysis of the Screening Process / K. Dane Wittrup, p. 111-126 -- ch. 7. Yeast n-Hybrid Systems for Molecular Evolution / Brian T. Carter, Hening Lin and Virginia W. Cornish, p. 127-158 -- ch. 8. Advanced Screening Strategies for Biocatalyst Discovery / Andreas Schwienhorst, p. 159-175 -- ch. 9. Engineering Protein Evolution / Stefan Lutz and Stephen J. Benkovic, p. 177-213 -- ch. 10. Exploring the Diversity of Heme Enzymes through Directed Evolution / Patrick C. Cirino and Frances H. Arnold, p. 215-243 -- ch. 11. Directed Evolution as a Means to Create Enantioselective Enzymes for Use in Organic Chemistry / Manfred T. Reetz and Karl-Erich Jaeger, p. 245-279 -- ch. 12. Applied Molecular Evolution of Enzymes Involved in Synthesis and Repair of DNA / John F. Davidson, Jon Anderson, Haiwei Guo, Daniel Landis and Lawrence A. Loeb, p. 281-307 -- ch. 13. Evolutionary Generation Versus Rational Design of Restriction Endonucleases with Novel Specificity / Thomas Lanio, Albert Jeltsch and Alfred Pingoud, p. 309-327 -- ch. 14. Evolutionary Generation of Enzymes with Novel Substrate Specificities / Uwe T. Bornscheuer, p. 329-341.
  • 1979-
    PrintStatus: Not Checked OutLane Catalog Record
  • 1978-
    PrintStatus: Not Checked OutLane Catalog Record
  • 2005 CRCnetBASE
    Spada, Stefania; Walsh, Gary.
  • 1978
    PrintStatus: Not Checked OutLane Catalog Record
  • 1970-71.
    PrintStatus: Not Checked OutLane Catalog Record
  • 1978-
    PrintStatus: Not Checked OutLane Catalog Record
  • 1925-
  • 2006 CRCnetBASE
    McGrath, Barry M.; Walsh, Gary.
    Applied enzymology: an overview / Nancy Shanley and Gary Walsh -- Enzyme engineering / Barry M. McGrath -- Tissue plasminogen activator-based thrombolytic agents / Gary Walsh -- Activated protein C / Brian W. Grinnell, S. Betty Yan, and William L. Macias -- Deoxyribonuclease I / Niek N. Sanders, Stefaan C. de Smedt, and Joseph Demeester -- SS-glucocerebrosidase ceredase and cerezyme / Tim Edmunds -- A-galactosidase / Debra Barngrover -- Urate oxidase / Alain Bayol ... [et al.] -- L-asparaginase review of pharmacology, drug resistance, and clinical applications / Christine Mauz-Korholz, Volker Wahn, and Dieter Korholz -- Recombinant factor VIIa / Elisabeth Erhardtsen ... [et al.] -- Factor IX (protease zymogen) / Barry M. McGrath -- The development of aldurazyme (laronidase) / Emil Kakkis -- Additional therapeutic enzymes / Shane O'Connell.
  • 1970-
    PrintStatus: Not Checked OutLane Catalog Record
  • Google Books
    Also available: Print – 1979-
  • 2009 Springer
    MacLachlan, Malcolm; Swartz, Leslie.
  • Kovar, Mary Grace; Forbes, William F.; Weeks, Julie Dawson.
    Also available: Print – 1995
  • 2007 Springer
    Rispler-Chaim, Vardit.
    Analyzes attitudes to people with various disabilities based on Muslim jurists' works (fiqh) in the Middle Ages and the modern era. This book focuses on people with disabilities and depicts the place and status that Islamic law has assigned to them, as well as how the law envisions their participation in religious, social, and communal life.
  • 2006
    Metzler, Irina.
    PrintStatus: Not Checked OutLane Catalog Record
  • 1951-
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Springer
    Capodaglio, Paolo; Faintuch, Joel; Liuzzi, Antonio.
    "Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity"--Provided by publisher.
  • 2013 Springer
    MacGarty, David; Nott, David.
    Disaster Response -- Immediate Response to Disasters -- Priorities in Post-disaster Management -- Refugee Camps -- Complex Emergencies -- Security for the Humanitarian Worker -- Global Players -- Global Development: Millennium Development Goals -- Nongovernmental Organizations and Aid -- Developing Healthcare Systems -- International Aid -- Future of Global Health -- Trauma and Surgery -- Prehospital Care -- Mass Casualty Incident -- Military Trauma -- Tropical Surgery -- Surgery in Austere Environments -- Tropical Medicine -- Polio and Vaccination Campaigns -- Malaria in Children -- Cholera: An Infectious Waterborne Disease -- HIV/AIDS -- Blinding Eye Diseases -- Public Health -- Malnutrition -- Sexual and Reproductive Health -- Maternal and Neonatal Health -- Mental Health Following Armed Conflict -- The Global Crisis in Noncommunicable Disease.
  • 2007 Ovid
    Burstein, Jonathan L.; Hogan, David E.
    General concepts -- Basic perspectives on disaster / David E. Hogan and Jonathan L. Burstein -- Triage / David E. Hogan and Julio Rafael Lairet -- Pediatric considerations in disasters / Mark A. Brandenburg -- Public health disasters / Eric K. Noji -- Infectious diseases and disasters / P. Gregg Greenough -- Pharmaceuticals in disasters / Robie V. Harrington -- Critical incident stress / Neill S. Oster and Constance J. Doyle -- Urban search and rescue / Carl S. Goodman and David E. Hogan -- Complex humanitarian emergencies / Frederick M. Burkle -- Disaster response planning and coordination -- Principles of hospital disaster planning / Erik Auf der Heide -- Emergency medical services in disasters / David W. Callaway -- Local government emergency disaster planning / Aden E. Hogan -- The United States national response plan / David E. Hogan and Jonathan L. Burstein -- Communication and information technology tools for disaster response and medical assistance / Victoria Garshnek and Frederick M. Burkle -- Managing disasters in austere environments / James P. McClay, Kim Moore, and David E. Hogan -- Natural disasters -- Earthquakes / Carl H. Schultz -- Tornadoes / David E. Hogan -- Hurricanes / John T. Meredith -- Floods / James Poole and David E. Hogan -- Firestorms and wildfires / Robert R. Frantz. Winter storms / Aaron Q. Lane and S. Brent Barnes -- Avalanches / Aaron Q. Lane and Jennifer Eischen -- Heat-related disasters / Glen Bailey and James S. Walker -- Volcanic eruptions / David E. Hogan and Jeremy Bearden -- Tsunamis / Kim Moore and David E. Hogan -- Industrial, technological, and transportation disasters -- Medical management of radiation incidents / Fun H. Fong, Jr. -- Hazardous materials emergencies / Howard W. Levitin and Henry J. Siegelson -- Mass gathering medical care / Steven J. Parrillo -- Maritime disasters / Jennifer Eischen -- Air crash disasters / Julio Rafael Lairet and David E. Hogan -- Fires and mass burn care / David E. Hogan, Heidi Metheney, and Michael Houston -- Conflict-related disasters -- Conventional terrorist bombings / Daniel J. Dire -- Nuclear detonations: evaluation and response / Fun H. Fong, Jr. -- Intentional chemical disasters / Mark Edward Keim and Jonathan L. Burstein -- Biological weapons agents / George W. Christopher ... [et al.] -- Tactical emergency services / David W. Callaway -- Mass shootings / Thomas M. Stein -- Education, training and research -- Education and training in disaster medicine / Ted Kellison, Timothy A. Soult, and David E. Hogan -- Research in disaster medicine / Kobi Peleg and Limor Aharonson-Daniel.
  • 2014 Springer
    Cefalu, Charles.
    Disaster Preparedness for Seniors: A Comprehensive Guide for Healthcare Professionals outlines specific disaster scenarios for homebound, community, hospitalized, long term care, homeless and aged veterans. Chapters are written by a diverse group of authors, all of whom offer insight and expertise in training healthcare professionals in preparing for disasters. Topics include myths and realities of natural disasters and disaster preparedness for special populations of elders-the acute care elderly, the community-dwelling elderly, home based primary care senior veterans, the immune-compromised elderly, those with multiple and co morbid illnesses, the long-term care elderly, those elderly at the end of life and the effects of disaster on caregivers. A significant portion of the book is also devoted to training, competencies, literacy, cultural competency and resilience in disaster preparedness as well as the role of the academic medical center. The volume concludes with coverage of the management of behavioral, medical and psychological consequences of disasters. Disaster Preparedness for Seniors: A Comprehensive Guide for Healthcare Professionals is an important new volume and will serve as a guide for the development of programs, policies and procedures for evacuation of seniors during various disaster scenarios.
  • 2009 ScienceDirect
    Clements, Bruce.
    General public health preparedness -- Bioterrorism -- Bombings and explosions -- Chemical disasters -- Earthquakes -- Floods -- Heat waves -- Hurricanes -- Nuclear and radiological disasters -- Pandemic influenza -- Thunderstorms and tornadoes -- Volcanoes -- Wildfires -- Winter storms.
  • 2015 Springer
    Templeton, Allen C.
    This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.
  • 2006 Springer
    Eisenhaber, Frank.
    Bioinformatics: mystery, astrology, or service technology? / Frank Eisenhaber -- Reliable and specific protein function prediction by combining homology with genomic(s) context / Martijn A. Huynen, Berend Snel, and Toni Gabalden -- Clues from three-dimensional structure analysis and molecular modelling: new insights into cytochrome P450 mechanisms and functions / Karin Schleinkofer and Thomas Dandekar -- Prediction of protein function: two basic concepts and one practical recipe / Frank Eisenhaber -- Extracting information for meaningful function inference through text-mining / Hong Pan ... [et al.] -- Literature and genome data mining for prioritizing disease-associated genes / Carolina Perez-Iratxeta, Peer Bork, and Miguel A. Andrade -- Model-based inference of transcriptional regulatory mechanisms from DNA microarray data / Harmen J. Bussemaker -- The predictive power of molecular network modelling: case studies of predictions with subsequent experimental verification / Stefan Schuster, Edda Klipp, and Marko Marhl -- Theory of early molecular evolution: predictions and confirmations / Edward N. Trifonov -- Hitchhiking mapping: limitations and potential for the identification of ecologically important genes / Christian Schlötterer -- Understanding the functional importance of human single nucleotide polymorphisms / Saurabh Asthana and Shamil Sunyaev -- Correlations between quantitative measures of genome evolution, expression, and function / Yuri I. Wolf, Liran Carmel, and Eugene V. Koonin.
  • 2005 ebrary
    Larose, Daniel T.
  • 2012
    Holmes, Kristen Jones; Cyert, Martha S.; Sarnow, P.; Simon, Michael; Skotheim, Jan.
    Whi3 is an RNA binding protein that regulates cell cycle entry by binding to mRNA of the G1 cyclin CLN3 and to the cyclin-dependent kinase Cdc28. Cln3 binds to Cdc28 to promote passage through Start. whi3[delta] cells have a small size phenotype, and Whi3 may regulate cell size by sequestering CLN3 mRNA and Cdc28 protein in the cytoplasm to delay G1 entry (Wang et al., 2004). We observe that Whi3 reversibly localizes from the cytosol to cytoplasmic puncta in response to glucose deprivation and heat shock. This phenotype is shared by components of stress granules (SGs), which are large RNP complexes that form in yeast in response to various stress conditions; SGs sort and process mRNAs during the stress response (Buchan et al., 2008). Because Whi3 shares several characteristics with known SG components, including an RNA binding domain and stress-dependent relocalization, we hypothesize that Whi3 is a novel component of SGs. We show that Whi3 colocalizes with SG markers in response to glucose deprivation and heat shock. Preventing SG formation inhibits Whi3 foci formation. Like SG components, Whi3 is enriched in insoluble cell fractions during stress. Whi3 is not required for SG formation, but may be targeted to SGs to carry out a previously unknown function. We conclude that Whi3 is a novel component of yeast stress granules. This observation suggests an alternative model for Whi3 function: that Whi3 might regulate mRNA translation during stress by transporting mRNA to stress granules. We demonstrate that Whi3 regulates many of its interacting RNAs, and that this regulation may promote stress-dependent survival.
  • 2006
    Insel, Paul M.; Ross, Don; Turner, R. Elaine.
    PrintStatus: Not Checked OutLane Catalog Record
    Energy balance and weight management: finding your equilibrium -- Vitamins : vital keys to health -- Water and minerals : the ocean within -- Sports nutrition : eating for peak performance -- Life cycle : maternal and infant nutrition -- Life cycle : from childhood through adulthood -- Food safety and technology : microbial threats and genetic engineering -- World view of nutrition : the faces of global malnutrition. Food choices : nutrients and nourishment -- Nutrition guidelines : tools for a healthful diet -- Complementary nutrition: functional foods and dietary supplements -- The human body : from food to fuel -- Carbohydrates : simple sugars and complex chains -- Lipids : not just fat -- Proteins and amino acids : function follows form --
  • 2010
    Insel, Paul M.; Ross, Don; Turner, R. Elaine.
    PrintStatus: Not Checked OutLane Catalog Record
    Food choices : nutrients and nourishment -- Nutrition guidelines : tools for a healthful diet -- Complementary nutrition : functional foods and dietary supplements -- The human body : from food to fuel -- Carbohydrates : simple sugars and complex chains -- Lipids : not just fat -- Proteins and amino acids : function follows form -- Energy balance and weight management : finding your equilibrium -- Vitamins : vital keys to health -- Water and minerals : the ocean within -- Sports nutrition : eating for peak performance -- Life cycle : maternal and infant nutrition -- Life cycle : from childhood through adulthood -- Food safety and technology : microbial threats and genetic engineering -- World view of nutrition : the faces of global malnutrition.
  • 2012
    Hung, Tiffany; Chang, Howard Y.; Fire, Andrew Z.; Khavari, Paul A.; Wysocka, Joanna.
    Recent advances in transcriptome analysis have revealed a large number of non-protein coding transcripts that have previously been uncharacterized. A subset of these molecules, termed long noncoding RNAs (lncRNAs), has been implicated in the regulation of chromatin states. Here, we detail a journey of lncRNA discovery and analysis, beginning from the de novo discovery of lncRNAs within the promoters of cell cycle genes, followed by the functional characterization of select candidates. We characterize two examples that regulate the p53-mediated DNA damage response. LncRNA PANDA blocks the apoptosis pathway by inhibiting the transcription factor NF-YA, and lncRNA DINO regulates the p53 transcriptional response by regulating SET7-mediated post-translational modification. Altogether, these studies support a model whereby pervasive lncRNA transcripts, previously discarded as transcriptional byproducts, function through diverse mechanisms as critical regulators of biological pathways.
  • 2011
    Howery, Andrew E.; Du Bois, Justin; Khosla, Chaitan; Wender, Paul A.
    CLC chloride channels and transporters play diverse physiological roles in processes ranging from regulating bone-density, muscle excitability, and blood pressure, to facilitating extreme-acid survival of pathogenic bacteria. Defects in CLC proteins cause human disorders in these processes. Small-molecule inhibitors of the CLCs would be useful as drugs for treating a variety of CLC-related human diseases and also to investigate CLC physiology. In addition, inhibitors are powerful tools for studying molecular mechanisms of Cl-- gating. Trapping channels or transporters in particular conformational states with high-affinity ligands could potentially advance our understanding of the structural basis for CLC activity. Despite their usefulness, specific small-molecule inhibitors for CLC proteins are scarce. To address this shortfall, we have exploited the 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) scaffold to develop two novel classes of CLC inhibitors. DIDS has been used as an anion-transport inhibitor for decades and was first used to inhibit CLCs over 30 years ago. However, experiments to determine the compound's mode of inhibition led us to discover that minor contaminants in the DIDS solutions inhibit CLC proteins more effectively than DIDS itself. The contaminants were found to derive from hydrolysis of the labile isothiocyanate moieties. The structures of five major hydrolysis products were determined by 1H NMR, HRMS analysis, and chemical synthesis to be DIDS-based polythioureas. These compounds bind directly to the CLC proteins, as evidenced by the fact that they inhibit purified, reconstituted ClC-ec1 and that inhibition of ClC-Ka can be prevented by the point mutation N68D. These polythioureas are the highest affinity inhibitors known for the CLCs and provide a new class of chemical probes for dissecting the molecular mechanisms of chloride transport. The second class of identified CLC inhibitors combines the DIDS core structure with alkyl chain carboxylic acids. The most potent inhibitor identified, 4,4'-octanamidostilbene-2,2'-disulfonic acid (OADS), inhibits ClC-ec1 with an apparent affinity of 29 [Mu]M. As a means to identify the inhibitor-binding site, we synthesized photo-reactive diazirine derivatives of OADS and showed that these photo-affinity reagents specifically inhibit ClC-ec1. Experiments to identify the binding site using 'top-down' mass spectrometry, in which the protein is cleaved into peptide fragments via electron-capture dissociation, have identified an intracellular binding region encompassing 76 amino acids, or 16% of the protein. Current efforts using protease digestion procedures are focused on further refinement of the binding region. Once located, protein/inhibitor interactions gleaned from the labeling of ClC-ec1 could allow us to rationally design more potent inhibitors of CLC transporters and channels.
  • 2007 Wellcome Trust
    Christie, D. A.; Tansey, E. M.
  • v. 1-2, 1942-49.
    Parada Aparicio, Joaquín.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 NAP
    "Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities is part of a study of how data from clinical trials might best be shared. This document is designed as a framework for discussion and public comment. This framework is being released to stimulate reactions and comments from stakeholders and the public. The framework summarizes the committee's initial thoughts on guiding principles that underpin responsible sharing of clinical trial data, defines key elements of clinical trial data and data sharing, and describes a selected set of clinical trial data sharing activities."--Publisher's website.
  • 2006 NCBI Bookshelf
    Feachem, Richard G.; Jamison, Dean T.; Makgoba, Malegapuru W.
    Changing patterns of disease and mortality in Sub-Saharan Africa: an overview / Florence K. Baingana and Eduard R. Bos -- Levels and trends in mortality in Sub-Saharan Africa: an overview / Jacob Adetunji and Eduard R. Bos -- Trends in child mortality, 1960 to 2000 / Kenneth Hill and Agbessi Amouzou -- Levels and trends of adult mortality / Debbie Bradshaw and Ian M. Timaeus -- Causes of death / Chalapati Rao, Alan D. Lopez, and Yusuf Hemed -- Population and mortality after AIDS / Rodolfo A. Bulatao -- Levels and patterns of mortality at INDEPTH demographic surveillance systems / Osman A. Sankoh ... [et al.] -- Trends and issues in child undernutrition / Todd Benson and Meera Shekar -- Diarrheal diseases / Cynthia Boschi-Pinto, Claudio F. Lanata, Walter Mendoza, and Demissie Habte -- Developmental disabilities / Geoff Solarsh and Karen J. Hofman -- Acute respiratory infections / Shabir A. Mahdi and Keith P. Klugman -- Vaccine-preventable diseases / Mark A. Miller and John T. Sentz -- Tuberculosis / Christopher Dye ... [et al.] -- Malaria / Robert W. Snow and Judy A. Omumbo -- Onchocerciasis / Uche Amazigo ... [et al.] -- Maternal mortality / Khama O. Rogo, John Oucho, and Philip Mwalali -- HIV/AIDS / Souleymane Mboup ... [et al.] -- Lifestyle and related risk factors for chronic diseases / Krisela Steyn and Albertino Damasceno -- Diabetes mellitus / Jean-Claude Mbanya and Kaushik Ramiaya -- Cancers / Freddy Sitas ... [et al.] -- Cardiovascular disease / Anthony Mbewu and Jean-Claude Mbanya -- Mental health and the abuse of alcohol and controlled substances / Florence K. Baingana, Atalay Alem, and Rachel Jenkins -- Neurological disorders / Donald Silberberg and Elly Katabira -- Violence and injuries / Brett Bowman ... [et al.].
  • 2006 NCBI Bookshelf
    Jamison, Dean T.
  • 2006
    PrintStatus: Not Checked OutLane Catalog Record
    Mental disorders / Steven Hyman ... [et al.] -- Neurological disorders / Vijay Chandra ... [et al.] -- Learning and developmental disabilities / Maureen S. Durkin ... [et al.] -- Alcohol / Jürgen Rehm ... [et al.] -- Illicit opiate abuse / Wayne Hall ... [et al.].
  • 2007 Springer
    Wobeser, Gary A.; Wobeser, Gary A.
  • 2006 Ovid
    Mental and emotional disorders -- Infection -- Trauma -- Neoplasms -- Immune disorders -- Hematologic disorders -- Cardiovascular disorders -- Respiratory disorders -- Neurologic disorders -- Musculoskeletal disorders -- Renal and urologic disorders -- Gastrointestinal disorders -- Metabolic disorders -- Endocrine disorders -- Obstetric and gynecologic disorders -- Eye disorders -- Ear, nose, and throat disorders -- Skin disorders.
  • v. 1-2, 1947-.
    Moncrieff, Alan; Paterson, Donald.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010 Springer
    Ahmad, Shamim I.
    Triple A syndrome / Vijaya Sarathi and Nalini S. Shah -- Amyotrophic lateral sclerosis / J. Jefferson ... [et al.] -- Early onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia 1 / Masayoshi Tada ... [et al.] -- Clinical features and pathogenesis of Alzheimer's disease : involvement of mitochondria and mitochondrial DNA / Michelangelo Mancuso ... [et al.] -- Huntington's disease / Emmanuel Roze ... [et al.] -- Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA) / Masahisa Katsuno ... [et al.] -- Spinocerebellar ataxia with axonal neuropathy / Cheryl Walton ... [et al.] -- Tuberous sclerosis complex and DNA repair / Samy L. Habib -- Hereditary photodermatoses / Dennis H. Oh and Graciela Spivak -- Trichothiodystrophy : photosensitive, TTDP, TTD,Tay syndrome / W. Clark Lambert, Claude E. Gagna, and Muriel W. Lambert -- Cornelia De Lange syndrome / Jinglan Liu and Gareth Baynam -- Rectal cancer and importance of chemoradiation in the treatment / Sergio Huerta -- Familial cutaneous melanoma / Johan Hansson -- Primary immunodeficiency syndromes / Mary A. Slatter and Andrew R. Gennery -- Inherited defects of immunoglobulin class switch recombination / Sven Kracker, Pauline Gardøs, and Anne Durandy -- Ligase IV syndrome / Dimitry A. Chistiakov -- Muir-Torre syndrome / Pedro Mercader -- Wilms' tumor / Carlos H. Martinez, Sumit Dave, and Jonathan Izawa -- Cerebro-oculo-facio-skeletal syndrome / Hiroshi Suzumura and Osamu Arisaka -- Dyskeratosis congenita / Vineeta Gupta and Akash Kumar -- Retinoblastoma / Dietmar Lohmann -- Von Hippel Lindau syndrome / Jenny J. Kim, Brian I. Rini, and Donna E. Hansel.
    Also available: Print – 2010
  • 2009 Springer
    Bruin, J.; Geest, L. P. S. van der.
  • 2011 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
    Emergency radiology of the abdomen: the acute abdomen -- Trauma of the abdomen and pelvis -- Diseases of the esophagus and stomach -- Small-bowel imaging: pitfalls in computed tomography enterography/enteroclysis -- Diseases of the small bowel, including the duodenum-MRI --Imaging of the colon and rectum: inflammatory and infectious diseases -- CT colonography: updated -- Imaging of diffuse and inflammatory liver diseases -- Focal liver lesions -- Imaging diseases of the gallbladder and bile ducts -- Diseases of the pancreas, I: pancreatitis -- Diseases of the pancreas, II: tumors -- Adrenal imaging and infection -- Renal tumors -- Urinary tract obstruction and infection -- Benign diseases of the female genital tract -- Malignant diseases of the female genital tract -- Magnetic resonance imaging of prostate cancer -- Imaging of the male pelvis: the scrotum -- Spread of metastatic disease in the abdomen and pelvis -- Abdominal vascular disease: diagnosis and therapy -- Non-vascular abdominal disease: diagnosis and therapy -- An approach to imaging the acute abdomen in the pediatric population -- Imaging uronephropathies in children -- Integrated imaging in genitourinary oncology: PET/CT imaging -- Integrated imaging in gastrointestinal oncology: PET/CT imaging -- Lymphoma: diagnostic and therapeutic applications of radiopharmaceuticals -- Conventional nuclear medicine in the evaluation of gastrointestinal and genitourinary tract disorders -- PET in hepatobiliary-pancreatic tumors -- PET in tumors of the digestive tract -- Tumors of the adrenergic system: imaging and therapy -- Neuroendocrine tumors of the abdomen: imaging and therapy -- Imaging cystic kidneys in children -- Understanding duplication anomalies of the kidney -- Malrotation: techniques, spectrum of appearances, pitfalls, and management -- Pediatric intestinal ultrasonography.
  • 2014 Springer
    Hodler, Jürg; Kubik-Huch, R. A.; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • 2006 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • Google Books
    Kershaw, James Martine.
    Contents -- pt. 1. Facial neuralgia and the visceralgiae, their diagnosis and treatment.
    Also available: Print – 1878-
  • 2012 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
    pt. 1. Workshops -- Brain Tumors / Edmond A. Knopp and Walter Montanera -- Mass Lesions of the Brain: A Differential Diagnostic Approach / Michael Brant-Zawadzki -- Differential Diagnosis of Brain Masses / James G. Smirniotopoulos and Steven J. Goldstein -- Evaluation of Cerebral Vessels / Robert A. Willinsky -- Evaluation of the Cerebral Vessels: Endovascular Therapy / Mary E. Jensen -- Brain Ischemia: CT and MRI Techniques in Acute Stroke / Jens Fiehler and Howard A. Rowley -- Hemorrhagic Vascular Pathologies, I / James Byrne -- Hemorrhagic Vascular Pathologies, II / Martin Wiesmann -- Demyelinating Diseases / Kelly K. Koeller and Frederik Barkhof -- Degenerative Brain Disease and Aging / Marco Essig and Mark A. van Buchem -- Neuroradiological Diagnosis of Craniocerebral Trauma: Current Concepts / Paul M. Parizel and C. Douglas Phillips -- Nontraumatic Neuroemergencies, I / Patrick A. Brouwer -- Nontraumatic Neuroemergencies, II / John R. Hesselink -- Epilepsy and Neuroimaging / Linda J. Bagley and Timo Krings -- Infectious Diseases of the Central Nervous System / Vincent Dousset and Alain Bonafé -- Cerebral Infections / David J. Mikulis -- Diseases of the Sella and Parasellar Region / Walter Kucharczyk and Charles L. Truwit -- Temporal Bone and Auditory Pathways / Jan W. Casselman and Francis Veillon -- Imaging Diseases of the Pharynx and Oral Cavity / Wendy R. K. Smoker and Bernhard Schuknecht -- Diseases of the Larynx / Martin G. Mack and Hugh D. Curtin -- Extramucosal Spaces of the Suprahyoid Neck / Laurie A. Loevner -- Sinonasal Imaging / David M. Yousem -- Degenerative Disc Disease of the Spine: Anatomic and Imaging Considerations / Michael T. Modic and Christian W. A. Pfirrmann -- Acute Spinal Trauma / Pia C. Sundgren and Adam E. Flanders -- Spinal Cord Inflammatory and Demyelinating Diseases / Majda M. Thurnher -- Spinal Inflammatory and Infectious Diseases / Jeffrey S. Ross -- Congenital and Acquired Abnormalities of the Pediatric Brain / William S. Ball and Thierry A. G. M. Huisman -- Imaging of Pediatric Brain and Spinal Cord Tumors / Tina Young Poussaint and Andrea Rossi -- pt. 2. Nuclear Medicine Satellite Course Diamond -- Imaging Alzheimer in 2011 / Marieke Hazewinkel and Frederik Barkhof -- Quantification of NeuroPET: When to Use It / Alfred Buck -- Radioiodine Therapy: Current Imaging Concepts Introduction / Luca Giovanella -- Nuclear Medicine Imaging of Brain Tumors / Ian Law -- Nuclear Imaging of Neurovascular Disease / Ian Law -- Integrated PET-CT and PET-MR: Pitfalls and Applications in Head and Neck Squamous Cell Carcinoma / Laurie A. Loevner -- PET Imaging of Dementia / Osama Sabri, Solveig Tiepolt, Swen Hesse and Henryk Barthel -- Clinical SPECT and PET for Management of Patients with Refractory Epilepsy / Koen Van Laere, Karolien Goffin and Wim Van Paesschen -- pt. 3. Pediatric Satellite Course Kangaroo -- Hemorrhage, Stroke, and Ischemia of the Neonatal Brain / Maria I. Argyropoulou -- Accidental and Nonaccidental Injury of the Pediatric Brain and Spine / Thierry A. G. M. Huisman -- Acquired Infectious and Autoimmune Diseases of the Pediatric Central Nervous System / Andrea Rossi -- Imaging of the Phakomatoses in Children / Tina Young Poussaint -- pt. 4. Breast Imaging Satellite Course -- MRI of the Breast: Technique, Indications, and BI-RADS Classification / Karen Kinkel -- Microcalcifications of the Breast: An Approach to Radiologic Classification / Markus Müller-Schimpfle -- Ultrasound of the Breast, Including Interventions: An Update / Alexander Mundinger -- Mammography: Diagnosis of Asymmetries, Masses and Architectural Distortion / Christian Weismann.
  • 2008 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • 2014 Ovid
    Harris, Jay R.; Lippman, Marc E.; Morrow, Monica; Osborne, C. Kent.
    SECTION I BREAST ANATOMY AND DEVELOPMENT -- ch. 1 Breast Anatomy and Development / Susan K. Boolbol -- ch. 2 Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives / Max S. Wicha -- SECTION II DIAGNOSIS AND MANAGEMENT OF BENIGN BREAST DISEASE -- ch. 3 Physical Examination of the Breast / Monica Morrow -- ch. 4 Management of the Palpable Breast Mass / Richard J. Bleicher -- ch. 5 Management of Disorders of the Ductal System and Infections / Nigel J. Bundred -- ch. 6 Management of Breast Pain / Robert E. Mansel -- ch. 7 Abnormalities of the Breast in Pregnancy and Lactation / Holly S. Mason -- ch. 8 Management of Gynecomastia / Glenn D. Braunstein -- ch. 9 Pathology of Benign Breast Disorders / Stuart J. Schnitt -- SECTION III BREAST IMAGING AND IMAGE-GUIDED BIOPSY TECHNIQUES -- ch. 10 Breast Cancer Screening / Joann G. Elmore -- ch. 11 Imaging Analysis: Mammography / Stephanie K. Patterson -- ch. 12 Imaging Analysis: Ultrasonography / Emily L. Sedgwick -- ch. 13 Imaging Analysis: Magnetic Resonance Imaging / Susan Orel Roth -- ch. 14 New Breast Imaging Techniques / Maxine S. Jochelson -- ch. 15 Image-Guided Biopsy of Nonpalpable Breast Lesions / Christopher E. Comstock -- SECTION IV EPIDEMIOLOGY AND ASSESSING AND MANAGING RISK -- ch. 16 Inherited Genetic Factors and Breast Cancer / Alan Ashworth -- ch. 17 Genetic Testing and Management of Patients with Hereditary Breast Cancer / Claudine Isaacs -- ch. 18 Nongenetic Factors in the Causation of Breast Cancer / Graham A. Colditz -- ch. 19 Management of Other High Risk Patients / Seema A. Khan -- ch. 20 Chemoprevention / Powel H. Brown -- SECTION V IN SITU CARCINOMA -- ch. 21 Ductal Carcinoma In Situ and Other Intraductal Lesions: Pathology, Immunohistochemistry, and Molecular Alterations / Edi Brogi -- ch. 22 Lobular Carcinoma In Situ: Biology and Management / Jorge S. Reis-Filho -- ch. 23 Ductal Carcinoma In Situ and Microinvasive Carcinoma / Jay R. Harris -- SECTION VI PATHOLOGY AND BIOLOGICAL MARKERS OF INVASIVE BREAST CANCER -- ch. 24 Genomic Events in Breast Cancer Progression / Matthew J. Ellis -- ch. 25 Pathology of Invasive Breast Cancer / Stuart J. Schnitt -- ch. 26 Estrogen and Progesterone Receptor Testing for Prognosis and Prediction / William Miller -- ch. 27 HER2/ERBB2 Testing: Assessment of Status for Targeted Therapies / Yanling Ma -- ch. 28 Clinical and Pathologic Prognostic and Predictive Factors 6 / Frederick L. Moffat -- ch. 29 Genomics, Prognosis, and Therapeutic Interventions / Charles M. Perou -- ch. 30 Bone Marrow Micrometastases and Circulating Tumor Cells / Daniel F. Hayes -- SECTION VII MANAGEMENT OF PRIMARY INVASIVE BREAST CANCER -- ch. 31 Evaluation of Patients for Metastasis Prior to Primary Therapy / C. Kent Osborne -- ch. 32 Staging of Breast Cancer / Jay R. Harris -- ch. 33 Mastectomy / Mehra Golshan -- ch. 34 Contralateral Prophylactic Mastectomy / Todd M. Tuttle -- ch. 35 Breast-Conserving Therapy / Monica Morrow -- ch. 36 Breast Reconstruction / Alice Y. Ho -- ch. 37 Sentinel Lymph Node Biopsy / Armando E. Giuliano -- ch. 38 Axillary Dissection / George Plitas -- ch. 39 Preserving and Restoring Function after Local Treatment / Andrea L. Cheville -- ch. 40 Lymphedema / Sarah A. Mclaughlin -- ch. 41 Local Management of the Axilla / Jay R. Harris -- ch. 42 Postmastectomy Radiation Therapy / Bruce G. Haffty -- ch. 43 Adjuvant Systemic Therapy: Endocrine Therapy / C. Kent Osborne -- ch. 44 Adjuvant Systemic Chemotherapy in Early Breast Cancer / Clifford A. Hudis -- ch. 45 Adjuvant Chemo Endocrine Therapy / Nancy E. Davidson -- ch. 46 Adjuvant and Preoperative Systemic Therapy for HER2-Positive Breast Cancer / Eric P. Winer -- ch. 47 Adjuvant Systemic Therapy: Bone-Targeted Treatments / Robert E. Coleman -- ch. 48 Pharmacogenomics of Systemic Therapy / James M. Rae -- ch. 49 Implications of Obesity in Breast Cancer / Andrew J. Dannenberg -- ch. 50 Lifestyle Issues in Breast Cancer Survivors / Rowan T. Chlebowski -- ch. 51 Management of Menopausal Symptoms in Breast Cancer Survivors / Charles L. Loprinzi -- ch. 52 Long-Term and Late Effects of Primary Curative Intent Therapy: Neurocognitive, Cardiac, and Secondary Malignancies / Patricia A. Ganz -- ch. 53 Adjuvant Systemic Therapy Treatment Guidelines / C. Kent Osborne -- SECTION VIII PREOPERATIVE SYSTEMIC THERAPY -- ch. 54 Preoperative Chemotherapy for Operable Breast Cancer / Jose Baselga -- ch. 55 Preoperative Endocrine Therapy for Operable Breast Cancer / Ian E. Smith -- ch. 56 Pathologic Assessment of Treatment Response after Neoadjuvant Therapy / Susan Carole Lester -- ch. 57 Local-Regional Therapy following Systemic Treatment / Kelly K. Hunt -- ch. 58 Locally Advanced Breast Cancer / Eric A. Strom -- ch. 59 Inflammatory Breast Cancer / Lori J. Pierce -- ch. 60 Preoperative Systemic Therapy for Breast Cancer / Marc E. Lippman -- SECTION IX SPECIAL THERAPEUTIC PROBLEMS -- ch. 61 Male Breast Cancer / William J. Gradishar -- ch. 62 Phyllodes Tumors / Benjamin O. Anderson -- ch. 63 Paget's Disease / Nora M. Hansen -- ch. 64 Nonepithelial Malignancies of the Breast / Carolina Gutierrez -- ch. 65 Breast Cancer during Pregnancy and Subsequent Pregnancy in Breast Cancer Survivors / Richard L. Theriault -- ch. 66 Occult Primary Cancer with Axillary Metastases / Youlia M. Kirova -- SECTION X EVALUATION AFTER PRIMARY THERAPY AND MANAGEMENT OF RECURRENT BREAST CANCER -- ch. 67 Surveillance of Patients following Primary Therapy / Robert W. Carlson -- ch. 68 Surgery for the Primary in Patients with Distant Metastases / Tari A. King -- ch. 69 Management of Local Regional Recurrences after Primary Breast Cancer Treatment / Erica L. Mayer -- ch. 70 Treatment of Metastatic Breast Cancer: Endocrine / Gaia Schiavon -- ch. 71 Treatment of Metastatic Breast Cancer: Chemotherapy / Antonio C. Wolff -- ch. 72 Treatment of HER2-overexpressing Metastatic Breast Cancer / Mark D. Pegram -- ch. 73 Palliative Care in Breast Cancer / Thomas J. Smith -- ch. 74 Management Summary for the Care of Patients with Metastatic Breast Cancer / Marc E. Lippman -- SECTION XI NEW BREAST CANCER THERAPEUTIC APPROACHES -- ch. 75 Newer Targeted Therapy / Carlos L. Arteaga -- SECTION XII SITE-SPECIFIC THERAPY OF METASTATIC BREAST CANCER -- ch. 76 Brain Metastases / Ian F. Dunn -- ch. 77 Metastatic Epidural Spinal Cord Compression / Patrick Y. Wen -- ch. 78 Leptomeningeal Metastasis / Lisa M. Deangelis -- ch. 79 Brachial Plexopathy in Patients with Breast Cancer / Pauline T. Truong -- ch. 80 Ophthalmic Metastases / David H. Abramson -- ch. 81 Management of Isolated Liver Metastases / Steven Come -- ch. 82 Medical Treatment for Bone Metastases / Christy A. Russell -- ch. 83 Local Management of Bone Metastases / James A. Hayman -- SECTION XIII BREAST CANCER IN SPECIAL POPULATIONS -- ch. 84 Breast Cancer in Older Women / Hyman B. Muss -- ch. 85 Breast Cancer in Younger Women / Richard D. Gelber -- ch. 86 Breast Cancer in Minority Women / Lisa A. Carey -- SECTION XIV ISSUES IN BREAST CANCER SURVIVORSHIP -- ch. 87 Nursing Care in Patient Management and Quality of Life / Deborah K. Walker -- ch. 88 Overview of Survivorship Issues / Larissa Nekhlyudov -- ch. 89 Psychosocial Adaptation during and after Breast Cancer / Mary Jane Massie -- ch. 90 Reproductive Issues in Breast Cancer Survivors / Elizabeth S. Ginsburg -- ch. 91 Cost and Cost Effectiveness Considerations / Bruce E. Hillner
  • 2010 Ovid
    Harris, Jay R.; Lippman, Marc E.; Morrow, Monica; Osborne, C. Kent.
    Breast anatomy and development -- Molecular mechanisms regulating breast development -- Stem cells in breast development and carcinogenesis: concepts and clinical perspectives -- Physical examination of the breast -- Management of the palpable breast mass -- Management of disorders of the ductal system and infections -- Management of breast pain -- Abnormalities of the breast in pregnancy and lactation -- Management of gynecomastia -- Pathology of benign breast disorders -- Screening for breast cancer -- Imaging analysis: mammography -- Breast ultrasound -- Imaging analysis: magnetic resonance imaging -- Imaging: new techniques -- Image-guided biopsy of nonpalpable breast lesions -- Management summary on breast imaging -- Inherited genetic factors and breast cancer -- Genetic testing and management of patients with hereditary breast cancer -- Nongenetic factors in the causation of breast cancer -- Management of other high risk patients -- Chemoprevention: clinical aspects -- Pathology and biological features of premalignant breast disease -- Lobular carcinoma in situ: biology and pathology -- Lobular carcinoma in situ: clinical management -- Ductal carcinoma in situ and microinvasive carcinoma -- Breast cancer genomics -- Pathology of invasive breast cancer -- Clinical aspects of estrogen and progesterone receptors -- ERBB2 testing: assessment of status for targeted therapies -- Prognostic and predictive markers -- Gene arrays, prognosis, and therapeutic interventions -- Bone marrow micrometastases and circulating tumor cells -- Evaluation of patients for metastasis prior to primary therapy -- Staging of breast cancer -- Mastectomy -- Breast-conserving therapy: conventional whole breast irradiation -- Breast-conserving therapy: accelerated partial breast irradiation -- Breast reconstruction -- Local therapy for the breast and chest wall -- Sentinel lymph node dissection -- Axillary dissection -- Axillary irradiation -- Preserving and restoring function after local treatment -- Lymphedema -- Treatment of the axilla and other regional nodes -- Postmastectomy radiation therapy -- Adjuvant systemic therapy: endocrine therapy -- Adjuvant systemic therapy: chemotherapy -- Adjuvant systemic therapy: chemoendocrine -- Adjuvant treatment of ERBB2 positive breast cancer -- Adjuvant systemic therapy: bisphosphonates -- Lifestyle issues in breast cancer survivors -- Management of menopausal symptoms in breast cancer survivors -- Side effects of systemic therapy: neurocognitive, cardiac, and secondary malignancies -- Pharmacogenomics of systemic therapy of breast cancer -- Guidelines for adjuvant systemic therapy -- Preoperative therapy for operable breast cancer -- Preoperative endocrine therapy for operable breast cancer -- Local-regional therapy considerations in patients receiving preoperative chemotherapy -- Locally advanced breast cancer -- Inflammatory breast cancer -- Management summary on preoperative systemic therapy -- Male breast cancer -- Phyllodes tumors -- Paget's disease -- Nonepithelial malignancies of the breast -- Breast cancer during pregnancy and subsequent pregnancy in breast cancer survivors -- Occult primary cancer with axillary metastases -- Surveillance of patients following primary therapy -- Surgery for the primary in patients with distant metastases -- Local-regional recurrence after breast-conservation treatment or mastectomy -- Treatment of metastatic breast cancer: endocrine therapy -- Treatment of metastatic breast cancer: chemotherapy -- Treatment of HER2-overexpressing metastatic breast cancer -- End-of-life considerations in patients with breast cancer -- Management summary for metastatic disease for the care of patients with metastatic disease -- Angiogenesis inhibition in breast cancer -- Tyrosine kinase inhibitors -- Newer targeted therapy in breast cancer -- Brain metastases -- Epidural metastases -- Leptomeningeal metastasis -- Brachial plexopathy in patients with breast cancer -- Ocular metastases -- Malignant effusions -- Management of discrete pulmonary nodules -- Management of lsolated liver metastases -- Bone-directed therapy and breast cancer: bisphosphonates, monoclonal anitbody, and radionuclides -- Local management of bone metastases -- Breast cancer in older women -- Breast cancer in younger women -- Breast cancer in minority women -- Nursing care in patient management and quality of life -- Psychosocial adaptation during and after breast cancer -- Reproductive issues in breast cancer survivors -- Medical legal aspects of breast cancer evaluation -- Cost and cost-effectiveness considerations.
  • 2015 Springer
    Hodler, Jürg; Kubik-Huch, R. A.; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • 2007 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • 2011 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • 2010 Springer
    Zarandy, Masoud Motasaddi; Rutka, John A.
    Temporal Bone Tumors and Metastatic Disease -- Cholesteatoma and Its Complications -- Anomalies of the Inner Ear -- Sudden Sensorineural Hearing Loss -- Trauma to the Inner Ear -- Otosclerosis -- Presbycusis -- Ménière's Syndrome -- Benign Positional Vertigo -- Meningioma -- Vestibular Schwannoma -- Other Cranial Nerve Schwannomas and Paragangliomas -- Ototoxicity.
  • 2007 Ovid
    Schrier, Robert W.
    Also available: Print – v. 1-3., 2007
  • 2014 Springer
    Horslen, Simon; Murray, Karen F.
    Diseases of the Liver in Children: Evaluation and Management provides a comprehensive, state-of-the art review of pediatric liver disease, with a practical approach useful for the primary care provider or general gastroenterologist. With an emphasis on tables and images, this book serves as a reference for understanding basic hepatic processes and the significance of laboratory findings. It also discusses the state of the art of diagnosis and treatment of diseases that affect the pediatric liver. The text captures the key elements of treatment and monitoring important for the primary care provider partnering in the care of these patients with pediatric hepatologists. The current state of transplantation and other surgical approaches are also discussed. The importance of aggressive bowel rehabilitation in the prevention of end-stage total parenteral nutrition-induced liver disease is also covered. Written by experts in their fields and including the most up to date clinical information, Diseases of the Liver in Children: Evaluation and Management serves as a very useful resource for physicians.
  • 2008 Springer
    Beger, H. G.; Cameron, John L.; Matsuno, Seiki.
  • 2012 Springer
    Lerma, Edgar V.; Licata, Angelo A.
    1. Molecular Mechanisms of Parathyroid Hormone Synthesis / Tally Naveh-Many and Morris Nechama -- 2. Regulation of Calcium and Phosphate Metabolism / Arthur D. Conigrave -- 3. Diagnosis and Treatment of the Patient with Abnormal Calcium / Elizabeth H. Holt -- 4. The Calcium-Sensing Receptor: Physiology and Pathophysiology / Friedhelm Raue and Christine Haag -- 5. New Concepts for Primary and Secondary Hyperparathyroidism / Joachim Beige and Peter Lamesch -- 6. Calcific Uremic Arteriolopathy (Calciphylaxis) / Earl H. Rudolph and Edgar V. Lerma -- 7. Cystic Parathyroid Lesions / Jean-François Henry and Maurizio Iacobone -- 8. Parathyroid Cancer / Maurizio Iacobone and Jean-François Henry -- 9. Biochemistry, Physiology, and Pathophysiology of Parathyroid Hormone-Related Peptide / Bandana Chakravarti, Shailendra K. Dhar Dwivedi, Ambrish Mithal and Naibedya Chattopadhyay -- 10. Ectopic Parathyroid Glands / Jean-François Henry and Maurizio Iacobone -- 11. Hyperparathyroidism in Multiple Endocrine Neoplasia / Syeda S. Zaidi, Vipul T. Lakhani and James T. Broome -- 12. Familial Hypocalciuric Hypercalcemia / Ogo I. Egbuna and Edward M. Brown -- 13. Hyperparathyroidism-Jaw Tumor Syndrome / Andrew C. Calabria and Michael A. Levine -- 14. Hypoparathyroidism and Pseudohypoparathyroidism / Rajesh V. Thakker -- 15. Primary Hyperparathyroidism in Neonates and Children / Eric Mallet and Mireille Castanet -- 16. Hypoparathyroidism in Children / Anne Lienhardt-Roussie and Agnès Linglart -- 17. Parathormone Resistance in Children / Agnès Linglart and Eric Mallet -- 18. The Use of Ultrasonography in the Management of Parathyroid Diseases / Zvonimir L. Milas and Mira Milas -- 19. Imaging in Parathyroid Diseases / Donald R. Neumann and Joyce J. Shin -- 20. Parathyroid Surgery / Zvonimir L. Milas and Mira Milas.
  • 2014 Springer
    Chang, Christopher C.; Gershwin, M. Eric; Incaudo, Gary.
    Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
  • 2006
    White, Gary M.; Cox, Neil H.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2015 Springer
    Hattingen, Elke.
    Spinal cord imaging has significantly benefited from new MR imaging methods such as cardiac-gated diffusion-weighted imaging, diffusion tensor imaging with fiber tracking, and time-resolved MR angiography. Recent decades have also witnessed fundamental progress in understanding of the pathophysiology of vascular, metabolic, and inflammatory spinal cord diseases. Furthermore, neurosurgical procedures and endovascular treatments of spinal cord diseases have been improved and perfected to avoid severe neurological sequelae. This textbook provides an interdisciplinary overview of the new imaging modalities, identifies clues for MR imaging diagnosis and differential diagnosis, and describes the anatomical background required to understand spinal cord diseases. Important neurological symptoms are highlighted, and modern treatment options for different diseases are fully explained and discussed. High-quality illustrations, including numerous images, are provided for all important spinal cord diseases, documenting relevant anatomical details, special MR imaging methods, differential diagnoses, and possible treatment procedures.
  • 2007 Karger
    Kiess, W.; Krassas, Gerasimos E.; Rivkees, Scott A.
    Ontogenesis and anatomy of the hypothalamic-pituitary-thyroid axis / Tsoumalis, G.; Tsatsoulis, A -- Thyroid disease during pregnancy / Lazarus, J.H -- Thyroid function in the newborn and infant / Spiliotis, B.E. -- Pediatric aspects of thyroid function and iodine / Knobel, M., Medeiros-Neto, G -- Thyroid hormone transport and actions / Feldt-Rasmussen, U., Rasmussen, Å.K. -- The thyroid and autoimmunity in children and adolescents / Weetman, A.P. -- Congenital hypothyroidism / Karges, B., Kiess, W. -- Newborn screening, hypothyroidism in infants, children and adolescents / Büyükgebiz, A. -- Resistance to thyroid hormone in childhood / Bakker, O. -- Pendred syndrome / Kassem, S., Glaser, B. -- Treatment of hyperthyroidism due to Graves' disease in children / Rivkees, S.A. -- Thyroid-associated ophthalmopathy in juvenile Graves' disease: clinical, endocrine and therapeutic aspects / Krassas, G.E., Gogakos, A. -- Differentiated thyroid carcinoma in pediatric age / Wiersinga, W.M. -- Imaging of the normal and affected thyroid in childhood / Bennedbæk, F.N., Hegedüs, L. -- Thyroid and other autoimmune diseases with emphasis on type 1 diabetes mellitus and Turner syndrome / Kapellen, T. ...[et al.] -- Thyroid and trace elements in children and adolescence / Kahaly, G.J.
  • 2014 Springer
    De Smet, Marc D.; Girach, Aniz.
    Disease of the vitreo-macular interface is characterized by vitreo-macular adhesion (VMA), which can lead to abnormal forces on the retina termed vitreo-macular traction (VMT). This combination of VMA and VMT can itself cause impairment of vision and is implicated in a variety of disorders, including wet age-related macular degeneration, diabetic retinopathy, macular edema, and macular hole. Vitreo-macular interface disease has recently begun to receive more attention owing in part to the advent of new imaging techniques that allow more accurate diagnosis and in part to advances in treatment. This clinically oriented book is the first to be devoted wholly to the diagnosis and treatment of vitreo-macular interface disease. World-renowned experts in the field discuss epidemiologic, anatomic, and physiologic aspects, document the findings obtained with newer imaging techniques, such as spectral domain optical coherence tomography, describe the treatment options, and report on the results of preclinical and clinical trials, including some previously unpublished findings. This book will prove invaluable for ophthalmologists as we advance toward a future in which treatments of diseases such as age-related macular degeneration and diabetic retinopathy will likely require adjunctive therapy to tackle VMA/VMT concurrently.
  • Google Books
    Galabin, Alfred Lewis; Galabin, Alfred Lewis; Galabin, Alfred Lewis.
    Also available: Print – 1884.
  • 2007 CRCnetBASE
    Manivannan, Gurusamy.
    Perspectives on infection challenges and solutions / Manivannan -- Sisyphus in the microbial world revisited : global governance, antimicrobial strategies, and humanity's health / Fidler -- The need for safer and better microbiocides for infection control / Sattar, Springthorpe -- Microbiological concerns in non-sterile manufacturing / Farrington, Polarine -- New technologies in disinfection and infection control / Ramirez -- Biocides : modes of action and mechanisms of resistance / McDonnell -- A pragmatic approach to judicious selection and proper use of disinfectant and antiseptic agents in healthcare setting / Suljagic -- Extended activity of healthcare antiseptic products / Newman, Kaiser -- Disinfectant rotation in a cleaning/disinfection program for cleanrooms and controlled environments / Sutton -- Reprocessing flexible endoscopes : origin of standards, overview of structure/function, and review of recent outbreaks / Antonucci, Williams, Robinson -- Microbiological testing of disinfectants and decontaminants for critical surfaces / Klein -- Regulatory constraints on disinfectants and decontamination / Sarli -- Biofilms : a summarized account and control strategies / Nandakumar, Sreekumari -- Consequences of biofilms on indwelling medical devices : costs and prevention / Thomas, Nakaishi, Corum -- Infection-resistant implantable devices : biofilm problems and design strategies / Smith, Perera -- Infections of intracardiac devices / Yesenosky ... [et al.] -- Intrauterine devices : infections and biofilms / Pereira, Pruthi -- Antimicrobial urinary catheters / Stickler, Sabbuba -- Risk factors for post-operative infectious complications after abdominal surgery / Pessaux, Lermite.
  • 2007 Karger
    Mishkin, Gary J.; Ronco, C.
    Antisepsis / Bianchi, P; Buoncristiani, E.; Buoncristiani, U. (Perugia) -- Sodium hypochlorite: history, properties, electrochemical production / Ponzano, G.P (Genova) -- Toxicity and safety of topical sodium hypochlorite / Bruch, M.K. (Hamilton, Va.) -- Disinfection of the dialysis monitors / Ghezzi, P.M. (Montemassi); Bonello, M. (Anagni); Ronco, C. (Vicenza) -- Biofilm on artificial surfaces / Cappelli, G. ... [et al.] -- Compatibility of electrolytically produced sodium hypochlorite solutions on long-term implanted dialysis catheters / Mishkin, G.J. (Gaithersburg, Md.) -- Hemodialysis catheter exit site care / Astle, C.M. (Edmonton) -- Effectiveness of sodium hypochlorite in the prevention of catheter related infections / Cruz, D.N. ... [et al.] -- Use of sodium hypochlorite in peritoneal dialysis : the genesis of the 'Y' set and beyond / Buoncristiani, U.; Buoncristiani, E.; Bianchi, P. (Perugia) -- Exit-site care in peritoneal dialysis / Wadhwa, N.K.; Reddy, G.H. (Stony Brook, N.Y.) -- Successful use of sodium hypochlorite pack plus systemic and local antibiotic therapy for the treatment of pseudomonas infection of peritoneal dialysis catheter exit-site / Rodighiero, M.P. ... [et al.] -- Disinfection of lines and transfer sets in peritoneal dialysis / Lew, S.Q.; Gruia, A. (Washington, D.C.) -- Amuchina 10% solution, safe antiseptic for preventing infections of exit-site of tenckhoff catheters, in the pediatric population of a dialysis program / Mendoza-Guevara, L. ... [et al.] -- Risk of peritonitis among disadvantaged CAPD patients in Mexico / Garcia-Garcia, G. ... [et al.].
    Also available: Print – 2007
  • 2005 Springer
    Kikkert, M.; Wiertz, E. J. H. J.
    The secretory capacity of a cell depends on the efficiency of endoplasmic reticulum-associated degradation / M. Molinari and R. Sitia -- Recognition and delivery of ERAD substrates to the proteasome and alternative paths for cell survival / A.A. McCracken and J.L. Brodsky -- CPY* and the power of yeast genetics in the elucidation of quality control and associated protein degradation of the endoplasmic reticulum / D.H. Wolf and A. Schäfer -- The role of the ubiquination machinery in dislocation and degradation of endoplasmic reticulum proteins / M. Kikkert, G. Hassink, and E. Wiertz -- The role of p97/Cdc48p in endoplasmic reticulum-associated degradation : from the immune system to yeast / S. Bar-Nun -- The ins and outs of intracellular peptides and antigen presentation by MHC Class I molecules / T. Groothuis and J. Neefjes -- Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane : co-opting basic mechanisms of endoplasmic reticulum-associated degradation / J.M. Lord , L.M. Roberts, and W.I. Lencer.
    Also available: Print – 2005
  • 2008 ScienceDirect
    Wijdicks, Eelco F. M.; Young, G. Bryan.
    Also available: Print – 2008
  • 2012 Springer
    Grover, Sonia R.; Hutson, John M.; Warne, G. L.
  • 2015 Springer
    Högl, Birgit; Videnović, Aleksandar.
    Part I -- 1. Introduction: Sleepy days and restless nights of Parkinson's Disease -- 2. Regulation of sleep and wake homeostasis -- 3. Neurochemistry of the sleep-wake cycle in Parkinson's disease -- 4. Impaired sleep and alertness in Parkinson's disease: what did we learn from animal models? -- 5. Objective measures of the sleep-wake cycle in Parkinson's disease -- 6. Subjective assessment of sleep and sleepiness in Parkinson's disease. Part II -- 7. Excessive daytime somnolence associated with Parkinson's disease -- 8. Insomnia in Parkinson's disease -- 9. Sleep-disordered breathing in Parkinson's disease -- 10. Restless legs syndrome and periodic limb movement disorder in Parkinson's disease -- 11. REM sleep behavior disorder -- 12. REM sleep behavior disorder: a pre-motor marker of Parkinson's disease -- 13. Dysregulation of circadian system in Parkinson's disease -- 14. Cognition and the sleep-wake cycle in Parkinson's disease -- 15. Fatigue and sleepiness in Parkinson's disease -- 16. Impact of surgical therapies on sleep and alertness in Parkinson's disease -- 17. Future directions.
  • 2015 Springer
    Fleming, Andrew N. M.; Trail, Ian.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2015 Springer
    Fleming, Andrew N. M.; Trail, Ian.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2015 Springer
    Fleming, Andrew N. M.; Trail, Ian.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2015 Springer
    Fleming, Andrew N. M.; Trail, Ian.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2008 Karger
    Flück, C. E.; Miller, Walter L.
    Steroidogenic enzymes / Miller, W.L. -- Disorders of adrenal development / Ferraz-de-Souza, B.; Achermann, J.C. -- Adrenal androgens in humans and nonhuman primates: production, zonation and regulation / Nguyen, A.D.; Conley, A.J. -- Clinical implications of androgen synthesis via 5[alpha]-reduced precursors / Ghayee, H.J.; Auchus, R.J. -- P450 oxidoreductase deficiency: a new form of congenital adrenal hyperplasia / Flück, C.E. ... [et al.] -- Long-term outcome of prenatal treatment of congenital adrenal hyperplasia / Lajic, S.; Nordenström, A.; Hirvikoski, T. -- Adrenocorticotropin resistance syndromes / Cooray, S.N. ... [et al.] -- Cushing Syndrome caused by adrenocortical tumors and hyperplasias (corticotropin-independent Cushing Syndrome) / Stratakis, S.A. -- The role of adrenal steroidogenesis in arterial hypertension / Mohaupt, M.G. -- Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome / Abbott, D.H. ... [et al.].
  • 2015 Springer
    Lioy, Janet; Sobol, Steven E.
    Disorders of the Neonatal Airway serves as a comprehensive, multidisciplinary resource for all practitioners who care for neonates with airway disorders. With the evolution of advances in neonatology and neonatal airway care over the past three decades, the survival rate and life expectancy of premature newborns have dramatically increased to well over 50% in 24-25 week gestation infants. Unfortunately, survival with long-term intubation has brought a corresponding increase in acquired airway disorders needing collaborative high level neonatal and otolaryngological care. Additionally, with the advent of fetal therapy, congenital airway disorders now make up a substantial number of neonates with complex airway disorders. Because of this fact, there has been increased focus on the multidisciplinary evaluation and management of neonatal airway disorders. The book is organized into three sections: the first focuses on Malformations and Deformations, the second focuses on Assessment, Evaluation, and Treatment, and the third discusses Education, Simulation, and Quality. As one of the only comprehensive resources on the topic, Disorders of the Neonatal Airway focuses on a multidisciplinary approach to the neonatal airway. This unique approach makes this reference a must read for practitioners from many disciplines.
  • 2006 Springer
    Mintz, Matthew L.
  • 2007 Ovid
    Iannotti, Joseph P.; Williams, Gerald R.
    Also available: Print – v. 1-2., 2007
  • 2015 Springer
    Cohen, Hannah; O'Brien, Patrick.
  • 2012 Springer
    Cohen, Hannah; O'Brien, Patrick.
  • 2013
    Hite, Dustin Howard; Brown, Patrick O.; Das, Rhiju; Herschlag, Daniel; Straight, Aaron.
    The central dogma of biology states that DNA, the genetic information, is transcribed into RNA, an information containing intermediate, which is then translated into proteins, actionable molecules which perform the majority of tasks required for life. To synthesize proteins, the cell employs a massive, macromolecular machine, the ribosome, and a myriad of protein factors to successfully translate an mRNA. My graduate studies have focused both on the ribosome and the protein translation factors that interact with the ribosome to facilitate translation initiation, elongation, and termination. First, utilizing recent advances in high throughput sequencing, we discovered that sequencing of ribosome protected fragments could illuminate in vivo dynamics of ribosome structural changes in Saccharomyces cerevisiae. We demonstrated that the ribosome protects two distinct sizes of fragments and assigned each fragment population to approximate stages of the translation elongation cycle where large structural rearrangements of the ribosome are known to occur. Once these assignments were made, we were able to model elongation speed and demonstrated that, contrary to previous reports, tRNA abundance and codon optimality were not the major determinants of elongation speed; surprisingly our data indicated that the polarity of the amino acid being decoded dictated elongation rates under these conditions, with polar amino acids acting to slow elongation rates. This study also implicated Dom34, a known NO GO decay factor, as a novel component of canonical translation termination and ribosome recycling. Second, we used another genome-wide assay of translation, "gradient encoding" microarray analysis, to interrogate the genome-wide effects of depleting five individual translation factors. Based on the current understanding of the molecular mechanisms of each translation factor, we hypothesized that the depletion of each factor would result in differential translation of mRNAs based on the physical properties of each mRNA species. However, we were startled to observe that the translational program of S. cerevisiae was relatively unperturbed by the depletion of three initiation factors, one elongation factor, and one termination factor. Further investigation revealed that yeast were actively compensating for the deficiency of each factor by either increasing or decreasing translation initiation rates such that the depleted factor was no longer limiting. This tuning was mediated by changes in eIF2[alpha] phosphorylation levels, a known modulator of translation initiation. Overall, we have leveraged high throughput technologies to provide novel understanding of in vivo structural dynamics of the ribosome and reveal a novel, unexpected robustness of the translational program in S. cerevisiae.
  • 2012
    Puri, Aaron Webster; Bogyo, Matthew; Chen, James; Mochly-Rosen, Daria; Monack, Denise M.
    Host-pathogen interactions are highly regulated at the post-translational level, making small molecules useful tools for dissecting many aspects of these events. This dissertation describes the development and application of chemical probes to examine aspects of bacterial infection on either side of the host-pathogen interface. We rationally designed a set of inhibitors and activity-based probes to study the substrate recognition and activation mechanisms of the internal cysteine protease domain (CPD) of Clostridium difficile's large gluocosylating toxin TcdB; a major virulence factor of this important nosocomial pathogen. Subsequent work with these tools has helped elucidate the biochemical details of CPD allosteric activation within a eukaryotic environment, and has provided evidence that TcdB contributes to hypervirulence in some C. difficile strains. We also developed an optimized activity-based probe for studying inflammasome-mediated caspase-1 activation, which is a fundamental part of the host's response to intracellular bacterial pathogens. We used this tool to discover that when cells are unable to activate caspase-1 upon intracellular bacterial infection, they instead undergo apoptosis. This work provides insight into a potential intracellular arms race between the host and pathogens capable of suppressing caspase-1 activation, and also highlights the balance that exists between pro- and non-inflammatory cellular responses. Together, these studies show there is much to be gained from adding chemical probes to the repertoire of tools used to study mechanisms of bacterial pathogenesis.
  • 2011
    Hwa, Jennifer; Clandinin, Thomas R.; Fuller, Margaret T.; Luo, Liqun; Shen, Kang.
    Neurons are morphologically diverse, with many anatomical specializations that are crucial for their functions. Photoreceptors represent a specialized class of neurons whose elaborated apical structures, the rhabdomeres, and specific axonal projections collect visual stimuli and transmit them to the appropriate synaptic partners, forming the basis for vision. Through genetic analyses in the Drosophila visual system, we have studied the molecular mechanisms that control these two aspects of photoreceptor morphology. A forward genetic screen identified the GTPase effector Genghis khan (Gek) as mediating the ability of a subset of photoreceptor neurons to target to their appropriate postsynaptic columns. Gek was not required for the layer targeting of a different subset of photoreceptors; however ectopic expression in these cells was sufficient to affect their targeting choices. Regulation of Gek's responses to targeting cues may underlie differences in target choices among photoreceptors. The specification of photoreceptor apical structures depends on genes of the apical -- basal polarity family. Mutants in the genes Crumbs (Crb) and Stardust (Sdt) are required for rhabdomere development in distinct but overlapping subsets of photoreceptors. In addition, both genes are required in all cell types for the formation of the adherens junctions contacts between cells, suggesting that Crb and Sdt have both overlapping and unique functions in photoreceptor morphogenesis. Thus, these experiments provide insight into how two aspects of photoreceptor morphology are determined, and suggest mechanisms by which cell type specific morphologies may be produced.
  • 2012
    Bogard, Patrick Evan; Brown, Patrick O.; Krasnow, Mark; Kuo, Calvin Jay; Straight, Aaron.
    One of the challenges facing modern medicine is to understand mammalian organ formation. Each organ has a specialized function and form, yet they are built from similar parts. One important part of each organ is the circulatory system, composed of arteries, veins, and capillaries, which is responsible for delivery of oxygen and nutrients and for the removal of carbon dioxide and metabolic waste. For centuries scientists have been trying to understand how the circulatory system functions and more recently how it forms. In this thesis, I focus on the development of the mouse pulmonary vasculature, the circulatory system that is responsible for transporting blood from the heart to the lungs where oxygenation occurs, and back to the heart where the oxygenated blood is pumped throughout the body. The lung is a complex organ made up of multiple hollow airway tubes that must form in coordination so that proper gas exchange can occur. In the first chapter I review the function and development of the circulatory system. In chapter two I present the experiments completed to determine the cellular origins of the blood vessels of the mouse lung and heart. Currently there are two major models for how the pulmonary arteries of the mouse form, vasculogenesis of lung mesenchymal endothelial progenitors and sprouting angiogenesis from vessels outside the lung. Using fate mapping I directly test the dominant model, vasculogenesis, and show that there are no endothelial progenitor cells resident in the lung mesenchyme. To determine if a vessel outside the lung is forming the pulmonary arteries I performed a clonal analysis labeling single endothelial cells before pulmonary artery formation and followed the fates of their daughter cells. I found a surprising multipotent progenitor population of endothelial cells, the primitive plexus of the lung, that gives rise to pulmonary arterial, venous, and plexus endothelial cells. I showed that the transition from plexus to arterial fate occurs in a leakproof manner in the lung by performing intracardiac perfusion experiments of fluorescently labeled dextrans and lectins. I also demonstrated a similar mechanism of leakproof plexus remodeling occurs in the heart during the development of the coronary arteries and veins. In chapter three I discuss experiments done to understand the molecular mechanisms controlling pulmonary artery formation. I describe an in silico in situ hybridization screen I performed to identify candidate molecules. I describe the expression pattern of BMP pathway activity in the lung as being restricted to the pulmonary arteries, a subset of the plexus and budding airways, using a transgenic mouse line that is only expressed in cells actively undergoing BMP signaling. I analyzed mice homozygously deficient for the BMP antagonists Gremlin and BMPER, and showed that there is no abnormal pulmonary artery formation or patterning phenotype. I also describe experiments in which I have deleted the BMP Receptor 2 from endothelial cells and again there is no abnormal pulmonary artery formation or patterning phenotype. I describe the expression pattern of VEGF in the lung as being mesenchymal during early lung formation, and show that mesenchymal deletions of VEGF do not result in abnormal pulmonary artery formation or patterning phenotypes. I found that multiple single gene manipulations do not result in abnormal phenotypes suggesting that pulmonary artery formation and patterning is robust and likely involves the interaction of multiple signaling pathways. This work describes a common mechanism of organ specific vascular bed formation that has not been previously described at a cellular and molecular level. I hope these studies provide a foundation for understanding how the vascular system of many organs form during organogenesis.
  • 2013
    Lowndes, Molly Pleasants; Attardi, Laura; Lipsick, Joseph Steven; Nelson, W. J.; Weis, William I.
    During normal development, tissue regeneration and cancer, epithelia undergo dramatic morphogenetic processes, ranging from cohesive sheet migration, cell position changes within cohesive tissues, to individual cell migration after dissociation from tissues. Such cell movements require coordination between cell migration and intercellular adhesion to maintaining tissue integrity. In epithelial cells, cell-cell adhesion complexes comprised of cadherins are crucial for these processes. I have investigated the unique roles of different cadherins in assembling adhesion complexes and coordinating migration. I show that cadherins are crucial for directing cellular migration, which is key for processes such as wound healing. The effect on cellular motility depends on the type of cadherin and the corresponding cell-cell complex involved. I show that the two types of desmosomal cadherins, which make up the desmosome, have distinct properties. Thus modulation of desmosomal cadherin interactions during development and cancer may provide a range of adhesive strengths that contributes to the regulation of morphogenetic cell movements.
  • 2012
    Bouley, Bradford Albert; Buc, Philippe; Findlen, Paula; Riskin, Jessica; Stokes, Laura.
    This dissertation explains how the body provided proof of holiness in early modern Catholicism. Tradition had long asserted that the bodies of especially saintly or sinful individuals should reveal signs of their elect status. In the early modern period, Church officials sought to make such vague ideas exact: they required medical proof of bodily holiness. This requirement arose out of developments in both medicine and Catholicism. After the Reformation, many Christians doubted how or even if they should venerate the saints. In response, the Catholic Church centralized and formalized canonization procedures. As part of this reform, canonization officials began to require that medical practitioners examine the cadavers of holy individuals. Medical and anatomical knowledge had progressed during this period to the point where dissection was thought to yield unique information about the lifestyle and habits of the deceased. This information could also include signs of a person's spiritual state. The body, interpreted through expert eyes, could now reveal a person's true nature. Together, medical practitioners and canon lawyers in the city of Rome created standards through which to interpret bodily signs of holiness. The methods of proof employed in these examinations presaged many techniques of knowledge production that would become a part of experimental practice in the early modern world. This dissertation therefore demonstrates that instead of being opposed, science and religion worked together to define the boundaries of the natural in human bodies.
  • 2011
    Peng, Kaitian; Falkow, Stanley; Lewis, David B.; Monack, Denise M.; Schneider, David.
    Francisella is a gram-negative bacterium that causes tularemia. It is capable of infecting a remarkably broad host range including humans, mammals, birds and fish via multiple different routes of infection, establishing a successful colonization event within the various organs. This facultative, intracellular pathogen is also capable of invading a broad range of host cell types ranging from macrophages to fibroblasts. This is an extremely fascinating facet of the bacterium. The ability of Francisella to infect such a wide range of hosts and cell types suggests that the bacterium either co-opts cellular mechanisms common to all hosts and cell types or has the requisite bacterial genes to adapt to many different intraorganismal environments, or both. We were interested in studying the diverse repertoire of interactions that may occur between the bacterium and its murine host. In this thesis, the transposon site hybridization (TraSH) negative selection strategy was applied in a range of in vivo and in vitro systems to identify novel host-pathogen interactions in Francisella. We subsequently demonstrated that Francisella require tryptophan for virulence specifically in the lungs due to lung-specific induction of a host innate immune molecule indoleamine 2,3-dioxygenase 1. Alveolar macrophages may also deplete intracellular trytophan via a novel mechanism and microbial lung-specific requirement of tryptophan for virulence may be widely applicable to all bacterial species. We also demonstrate that Francisella hypercytotoxic mutants, unlike previously suggested, induce macrophage hypercytotoxicity due to increased bacteriolysis in the intracellular milieu. Identification and characterization of bacterial mutants that are attenuated under different in vitro and in vivo conditions have led to further insights into the interactions that occur between Francisella and its murine host.
  • 2005 Springer
    Chuaqui, Rodrigo F.; Emmert-Buck, Michael R.; Gillespie, John W.
  • 2013
    Freifeld, Limor; Clandinin, Thomas R.; Horowitz, Mark Eden; Schnitzer, Mark Jacob.
    Visual inputs are high-dimensional, dynamic, and may consist of significant levels of noise. Nevertheless, visual processing systems in many animals are capable of efficiently extracting information out of these signals to guide behavior. Flies, in particular, use visual information to guide behavior in challenging conditions such as during rapid flight maneuvers. In this dissertation we examine how early visual processing cells in the visual system of the Fruit Fly, Drosophila, achieve this feat. In particular, we focus on cells that provide inputs to motion detecting circuits and assess how these cells balance the goal of facilitating computational specializations with the goal of efficiently capturing all visual information. In these studies, we used two-photon calcium imaging in vivo to monitor the responses of specific cells in the fly visual system to visual stimuli. Using this system, we found that two first order interneurons providing inputs to pathways specialized for the detection of moving bright and dark edges nevertheless similarly encode information about both brightening and darkening. However, an in depth study of the functional properties of one of these interneurons revealed that it responds differently to bright and dark moving objects of different sizes in a manner that could facilitate the downstream specialization. Furthermore, via genetic and pharmacological manipulations it was found that GABAergic circuits providing lateral and feedback inputs to this cell enhance its responses to dark stimuli and thus enable it to relay critical information for the downstream pathway. These circuits were found to give rise to a center-surround antagonistic, anisotropic and spatiotemporally coupled RF structure in this cell. Interestingly, our studies uncovered deep similarities between the function of early visual processing cells in the fly and in vertebrate retinas. This suggests that different systems have converged on a similar set of solutions for addressing the challenge of efficiently using the resources available to the nervous system to process visual signals.
  • 2012
    Nguyen-Vu, T.D. Barbara; Madison, Daniel V.; Moore, Tirin; Raymond, Jennifer L.; Shatz, Carla J.
    The focus of this thesis is to understand the contribution of multiple learning mechanisms to cerebellum-dependent motor learning. The studies that contribute to this thesis examine the role multiple learning mechanisms in the context of signaling in the intact circuit of awake-behaving animals. By using a well-parameterized learning paradigm, it is possible to distinguish and separate the contribution of specific learning mechanisms to different aspects of learning. This thesis demonstrates the sufficiency to two learning mechanisms long hypothesized to be important for cerebellum-dependent learning: 1) LTD at the parallel fiber to Purkinje cell synapse in the cortex (Marr 1969; Albus 1971; Ito 1972); and 2) the output of Purkinje cell simple spike activity (Miles & Lisberger 1981). Furthermore, the findings highlight the importance of understanding how learning mechanisms operate in vivo and interact with the on-going activity as well as previous activity in the circuit to determine different learning outcomes. The idea that the properties of a learning mechanism do not operate in isolation to produce learning but must be considered in the context of the intact and functional circuit is a common lesson that could apply to and should be tested in other learning systems of the brain.
  • 2014 Springer
    Hove, Leiv M.; Hølmer, Per; Lindau, Tommy.
    Distal radial fractures are still puzzling us 200 years after Colles' classic description. Despite the advent of various new imaging techniques, including 3D CT, the availability of diagnostic adjuncts such as arthroscopy, and treatment options that include more than 30 different volar locking plates, the rate of unsatisfactorytreatment resultsremains very high. Furthermore, while we are aware of more associated injuries, such as carpal ligament tears and injuries to the radioulnar ligament (TFCC), there is still intense debate on the relevance of these injuries. This textbook aims to provide the reader with a complete understanding of distal radius fractures, their inherent problems, and how to manage them successfully. It is written by widely published experts from a part of the globe where distal radius fractures are very common, especially during the winter months. Clear guidance is provided on diagnostic imaging, classification, and assessment of fracture instability. The complete spectrum of operative and nonoperative treatment options are then clearly explained with the aid of step-by-step illustrations. Extensive information is also provided on complications and their treatment. Both students and experienced practitioners will find this book to be an enlightening, practice-oriented reference on the management of these challenging fractures.
  • 2009
    Franco, Christopher Brian.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 Springer
    Dubitzky, Werner; Romberg, Mathilde; Schroeder, Michael; Schuster, Assaf; Sloot, Peter M. A.
  • 2007 Springer
    Tonchev, A. B.; Chaldakov, G. N.; Yamashima, T.
  • 2010 Springer
    Simon, Celeste M.
    The HIF-2[alpha]-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization / A. Pietras, A.S. Johnsson and S. Pahlman -- Hypoxia and hypoxia inducible factors in cancer stem cell maintenance / Z. Li and J.N. Rich -- Role of carcinoma-associated fibroblasts and hypoxia in tumor progression / A.J. Giaccia and E. Schipani -- The role of hypoxia regulated microRNAs in cancer / R. McCormick ... [et al.] -- Oxygen sensing: A common crossroad in cancer and neurodegeneration / A. Quaegebeur and P. Carmeliet -- Hypoxia-inducible factors as essential regulators of inflammation / H.Z. Imtiyaz and M.C. Simon -- Hypoxia and metastasis in breast cancer / H. Rundqvist and R.S. Johnson.
    Also available: Print – 2010
  • 2008 Springer
    Shakibaei, M.; Csaki, C.; Mobasheri, A.
  • 2008
  • 2013
    Dreachslin, Janice L.; Gilbert, M. Jean; Malone, Beverly.
    PrintStatus: Not Checked OutLane Catalog Record
    "Designed to provide ... a clear understanding of recent philosophies and processes undergirding diversity management, inclusion, and culturally competent care delivery as seen through the lens of current health care policy and practice. The textbook integrates strategic diversity management, self-reflective leadership and the personal change process, with culturally and linguistically appropriate care into a cohesive systems-oriented approach for health care professionals"--Excerpt from publisher notes.
  • 2009
    Lee, Philip R.; Franks, Patricia E.
    Executive summary -- Preface -- ch. 1. Changing opportunities and challenges for medical schools: from desegregation to affirmative action to promoting diversity in an anti-affirmative action environment -- ch. 2. Increasing access to U.S. medical schools for diverse populations: demographic, education, and medical school trends, 1960s-2000s, graduate medical education, and the U.S. physican workforce -- ch. 3. The Changing federal context -- ch. 4. California's people: demographic transformation, educational trends, and challenges for medical school and physician diversity -- ch. 5. California's changing policy context -- ch. 6. The University of California: the changing policy context of a public university -- ch. 7. Stanford University: the changing policy context of a private university -- ch. 8. Case studies of diversity: UCSF and Stanford medical schools -- ch. 9. Recommendations: opportunities for action to increase diversity -- Appendix 1. Archival research -- Appendix 2. Key informant interviews -- Appendix 3. Oral history interviews -- Appendix 4. Selected key reports related to diversity in medical schools and the health professions and the physician workforce.
  • 2005 Springer
    Kaminishi, Michio; Mafune, K.; Takubo, K.
  • 2014
    Speerstra, Karen; Anderson, Herbert.
    PrintStatus: Not Checked OutLane Catalog Record
    "The Divine Art of Dying" explores the unique moment when seriously ill people choose to turn toward death. Combining personal stories with solid research on palliative and hospice care, it provides a well-integrated look at the spiritual dimensions of living fully when death is near. Filled with insights from the world's great wisdom traditions along with references from literature, movies, and current culture, it helps identify the life decisions the dying one and his or her loved ones must make, and what their caregivers can expect.
  • 2013 IngentaConnect
    Sumich, Christi Keating.
    Divine Doctors and Dreadful Distempers examines the discourse of seventeenth-century English physicians to demonstrate that physicians utilized cultural attitudes and beliefs to create medical theory. They meshed moralism with medicine to self-fashion an image of themselves as knowledgeable health experts whose education assured good judgment and sage advice, and whose interest in the health of their patients surpassed the peddling of a single nostrum to everyone.
    Also available: Print – 2013
  • 2013 Springer
    Vogelsang, Matjaž.
    Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
  • 2014 CRCnetBASE
    Sozer, Amanda C.
    1. Human identification through DNA analysis -- 2. Mass fatalities -- 3. Postmortem functions : body recovery and morgue operations -- 4. Antemortem functions : family assistance operations -- 5. Identification of remains -- 6. Identification and collection of biological samples from human remains -- 7. Identification and collection of DNA reference samples -- 8. Application of DNA technology for human identification -- 9. DNA profile analysis and interpretation -- 10. DNA sample, case, and data tracking using information technology tools -- 11. Implementing and maintaining a quality DNA program -- 12. Laboratory development -- 13. Delivering effective training.
  • 2013 Springer
    Barciszewski, Jan; Erdmann, V. A.
    DNA and RNA nanobiotechnologies have currently reached the status of one of the most dynamic research areas in the field of drug delivery in molecular medicine. Scientists and bio-engineers are creating totally new nanometer-scale structures with unique biological properties for a wide range of medical applications. The book, written by world-leading scientists in this new field, gives an overview of various aspects and applications of DNA and RNA nanotechnologies. These include the design and synthesis of DNA and RNA nanostructures with the aim of using them for different kinds of drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, siRNA delivery for cancer treatment, and even analytical and therapeutic applications of aptamer-based nanoparticles. This volume will be of interest not only to graduate students and researchers in the field of molecular medicine and molecular biology, but also to chemists interested in the biological fields. As a matter of fact, the book contains so many new and unique approaches to this area of molecular medicine that it may inspire the interested reader to undertake research into nucleic acid nanotechnologies.
  • 2009 Springer Protocols
    Bugert, Peter.
    PCR-ELISA for high-throughput blood group genotyping / Maryse St-Louis -- Single base extension in multiplex blood group genotyping / Gregory A. Denomme -- Real-time PCR assays for high-throughput blood group genotyping / Fernando Araujo -- Real-time PCR assays for high-throughput human platelet antigen typing / Simon E. McBride -- Multiplex ABO genotyping by minisequencing / Gianmarco Ferri and Susi Pelotti -- Multiplex genotyping for thrombophilia-associated SNPs by universal bead arrays / Susan Bortolin -- Pyrosequencing of toll-like receptor polymorphisms of functional relevance / Parviz Ahmad-Nejad -- Multiplex HLA-typing by pyrosequencing / Ying Lu ... [et al.] -- High-throughput multiplex HLA-typing by ligase detection reaction (LDR) and universal array (UA) approach / Clarissa Consolandi -- Medium- to high-throughput SNP genotyping using VeraCode microbeads / Charles H. Lin ... [et al.] -- The use of maternal plasma for prenatal RhD blood group genotyping / Kirstin Finning, Pete Martin, and Geoff Daniels -- Nanoliter high-throughput PCR for DNA and RNA profiling / Colin J.H. Brenan, Douglas Roberts, and James Hurley -- RNA stabilization of peripheral blood and profiling by bead chip analysis / Svenja Debey-Pascher, Daniela Eggle, and Joachim L. Schultze -- RNA profiling in peripheral blood cells by fluorescent differential display PCR / Martin Steinau and Mangalathu S. Rajeevan -- cDNA amplification by SMART-PCR and suppression subtractive hybridization (SSH)-PCR / Andrew Hillmann, Eimear Dunne, and Dermot Kenny -- Transcript profiling of human platelets using microarray and serial analysis of gene expression (SAGE) / Dmitri V. Gnatenko ... [et al.] -- Genome-wide platelet RNA profiling in clinical samples / Angelika Schedel and Nina Rolf -- PCR-based amplification of platelet mRNA sequences obtained from small-scale platelet samples / Jutta M. Rox, Jens Müller, and Bernd Pötzsch -- MicroRNA profiling of megakaryocytes / Ramiro Garzon -- Serial analysis of gene expression adapted for downsized extracts / SAGE/SADE) analysis in reticulocytes / Béatrice Bonafoux and Thérèse Commes -- Real-time PCR analysis for blood cell lineage specific markers / Louise Edvardsson and Tor Olofsson -- Monitoring the immune response using real-time PCR / Patrick Stordeur.
  • 2002 CRCnetBASE
    Grigorenko, Elena V.
  • 2008 Springer
    Garzon, Max; Yan, Hao.
  • 2008 Springer
    Zimmermann, Karl-Heinz; Ignatova, Zoya; Martinez-Perez, Israel.
  • 2005 Springer
    Ohyama, Takashi.
    DNA: alternative conformations and biology / Vladimir N. Potaman and Richard R. Sinden -- Sequence-dependent variability of B-DNA: an update on bending and curvature / Victor B. Zhurkin ... [et al.] -- Curved DNA and prokaryotic promoters: a mechanism for activation of transcription / Munehiko Asayama and Takashi Ohyama -- Repression of transcription by curved DNA and nucleoid protein H-NS: a mode of bacterial gene regulation / Cynthia L. Pon, Stefano Stella and Claudio O. Gualerzi -- Curved DNA and transcription in eukaryotes / Takashi Ohyama -- Putative roles of kin17, a mammalian protein binding -- Curved DNA, in transcription / Jaime F. Angulo ... [et al.] -- Roles for Z- and double-stranded RNA in transcription: encoding genetic information by shape rather than by sequence / Alan Herbert -- Do DNA triple helices or quadruplexes have a role in transcription? / Michael W. Van Dyke -- Nucleic acid structures and the transcription defects in fragile X syndrome and Friedreich's ataxia / Karen Usdin -- Possible roles of DNA supercoiling in transcription / Susumu Hirose and Kuniharu Matsumoto -- Gene regulation by HMGA and HMGB chromosomal proteins and related architectural DNA-binding proteins / Andrew A. Travers -- Molecular mechanisms of male sex determination: the enigma of SRY / Michael A. Weiss -- The role of unusual DNA structures in chromatin organization for transcription / Takashi Ohyama -- DNA bendability and nucleosome positioning in transcriptional regulation / Mensur Dlaki, David W. Ussery and Sren Brunak.
  • v. 1-3, 1998-2001
    Hoekstra, Merl F.; Nickoloff, Jac A.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. DNA repair in prokaryotes and lower eukaryotes -- v. 2. DNA repair in higher eukaryotes -- v. 3. Advances from phage to humans.
  • 2009 Springer Protocols
    Didenko, Vladimir V.
    In situ detection of apoptosis by the TUNEL assay: An overview of techniques -- Combination of TUNEL assay with immunohistochemistry for simultaneous detection of DNA fragmentation and oxidative cell damage -- EM-ISEL: A useful tool to visualize DNA damage at the ultrastructural level -- In situ labeling of DNA breaks and apoptosis by T7 DNA polymerase -- In situ ligation: A decade and a half of experience -- In situ ligation simplified: Using PCR fragments for detection of double-strand DNA breaks in tissue sections -- 5'OH DNA breaks in apoptosis and their labeling by topoisomerase-based approach -- Detection of DNA strand breaks in apoptotic cells by flow- and image-cytometry -- Fluorochrome-labeled inhibitors of caspases: Convenient in vitro and in vivo markers of apoptotic cells for cytometric analysis -- Combining fluorescent in situ hybridization with the comet assay for targeted examination of DNA damage and repair -- Simultaneous labeling of single- and double-strand DNA breaks by DNA breakage detection-FISH (DBD-FISH) -- Co-localization of DNA repair proteins with UV-induced DNA damage in locally irradiated cells -- Ultrasound imaging of apoptosis: Spectroscopic detection of DNA-damage effects at high and low frequencies -- Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry -- ELISpot assay as a tool to study oxidative stress in peripheral blood mononuclear cells -- Cytokinesis-block micronucleus cytome assay in lymphocytes -- Buccal micronucleus cytome assay -- [Gamma]-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin -- Immunologic detection of benzo(a)pyrene-DNA adducts -- Non-invasive assessment of oxidatively damaged DNA: Liquid chromatography-tandem mass spectrometry analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine -- Assessing sperm DNA fragmentation with the sperm chromatin dispersion test.
  • 2005 CRCnetBASE
    Doetsch, Paul W.; Kow, Yoke Wah; Siede, Wolfram.
  • 2009 Springer
    Khanna, Kum Kum; Shiloh, Yosef.
    DNA Damage Sensing and Signaling / Daniel Durocher -- Signaling at Stalled Replication Forks / Daniel A. Mordes and David Cortez -- An Oncogene-Induced DNA Replication Stress Model for Cancer Development / Thanos D. Halazonetis -- Cellular Responses to Oxidative Stress / Inbal Dar and Ari Barzilai -- Cell Cycle Regulation and DNA Damage / Ryo Sakasai and Randal S. Tibbetts -- Chromatin Modifications Involved in the DNA Damage Response to Double Strand Breaks / Julia Pagan, Emma Bolderson, Mathew Jones and Kum Kum Khanna -- Telomere Metabolism and DNA Damage Response / Tej K. Pandita -- DNA Double Strand Break Repair: Mechanisms and Therapeutic Potential / Laura M. Williamson, Chris T. Williamson and Susan P. Lees-Miller -- DNA Base Excision Repair: A Recipe for Survival / Rabindra Roy and Sankar Mitra -- DNA Damage Tolerance and Translesion Synthesis / Alan R. Lehmann -- Nucleotide Excision Repair: from DNA Damage Processing to Human Disease / Mischa G. Vrouwe and Leon H.F. Mullenders -- Chromosomal Single-Strand Break Repair / Keith W. Caldecott -- Mouse Models of DNA Double Strand Break Repair Deficiency and Cancer / Sachin Katyal and Peter J. McKinnon -- Cancer Biomarkers Associated with Damage Response Genes / Anne E. Kiltie, Marie Fernet and Janet Hall -- Linking Human RecQ Helicases to DNA Damage Response and Aging / Wen-Hsing Cheng, Byungchan Ahn and Vilhelm A. Bohr -- Single-Stranded DNA Binding Proteins Involved in Genome Maintenance / Derek J. Richard and Kum Kum Khanna -- The Fanconi anemia-BRCA Pathway and Cancer / Toshiyasu Taniguchi -- BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment / Kienan Savage and D. Paul Harkin.
  • 2013 Springer Protocols
    Makovets, Svetlana.
    DNA electrophoresis: historical and theoretical perspectives / Gareth A. Roberts and David T.F. Dryden -- Basic DNA electrophoresis in molecular cloning: a comprehensive guide for beginners / Svetlana Makovets -- Analysis of branched DNA replication and recombination intermediates from prokaryotic cells by two-dimensional (2D) native-native agarose gel electrophoresis / Nicholas P. Robinson -- Analysis of DNA structures from eukaryotic cells by two-dimensional native-native DNA agarose gel electrophoresis / Andreas S. Ivessa -- Directionality of replication fork movement determined by two-dimensional native-native DNA agarose gel electrophoresis / Andreas S. Ivessa -- Native/denaturing two-dimensional DNA electrophoresis and its application to the analysis of recombination intermediates / Jessica P. Lao, Shangming Tang, and Neil Hunter -- Plasmid DNA topology assayed by two-dimensional agarose gel electrophoresis / Jorge B. Schvartzman [and three others] -- A neutral glyoxal gel electrophoresis method for the detection and semi-quantitation of DNA single-strand breaks / Brian Pachkowski and Jun Nakamura -- Denaturing gradient gel electrophoresis (DGGE) / Fiona Strathdee and Andrew Free -- Polyacrylamide temperature gradient gel electrophoresis / Viktor Viglasky -- Separation of DNA oligonucleotides using denaturing urea PAGE / Fiona Flett and Heidrun Interthal -- Pulsed-field gel electrophoresis of bacterial chromosomes / Julia S.P. Mawer and David R.F. Leach -- Resolution of budding yeast chromosomes using pulsed-field gel electrophoresis / Aziz El Hage and Jonathan Houseley -- Analysis of DNA damage via single-cell electrophoresis / Diana Anderson and Julian Laubenthal -- Fluorescence in situ hybridization on electrophoresed cells to detect sequence specific DNA damage / Julian Laubenthal and Diana Anderson -- Analysis of DNA-protein interactions using PAGE: band-shift assays / Lynn Powell -- Assaying cooperativity of protein -- DNA interactions using agarose gel electrophoresis / Tanya L. Williams and Daniel L. Levy -- DNA bending by proteins: utilizing plasmid pBendAT as a tool / Fenfei Leng -- Using PCR coupled to PAGE for detection and semiquantitative evaluation of telomerase activity / Laura Gardano.
  • 2012 Springer Protocols
    Alonso, Antonio.
    An overview of DNA typing methods for human identification : past, present, and future / Robyn Thompson, Silvia Zoppis, and Bruce McCord -- Capillary electrophoresis and 5-channel LIF detection of a 26plex autosomal STR asay for human identification / Carolyn R. Hill -- Capillary electrophoresis of miniSTR markers to genotype highly degraded DNA samples / Michael D. Coble -- Interpretation guidelines of a standard Y-chromosome STR 17-plex PCR-CE assay for crime casework / Lutz Roewer and Maria Geppert -- Capillary electrophoresis of an X-chromosome STR decaplex for kinship deficiency cases / Leonor Gusmão [and others] -- A 48-plex autosomal SNP GenPlex Assay for human individualization and relationship testing / Carmen Tomas, Claus Børsting, and Niels Morling -- Typing of 49 autosomal SNPs by single base extension and capillary electrophoresis for forensic genetic testing / Claus Børsting, Carmen Tomas, and Niels Morling -- A 34-plex autosomal SNP single base extension assay for ancestry investigations / C. Phillips, M. Fondevila, and Maria Victoria Lareau -- SNaPshot® minisequencing analysis of multiple ancestry-informative Y-SNPs using capillary electrophoresis / Maria Geppert and Lutz Roewer -- Capillary electrophoresis of 38 noncoding biallelic mini-indels for degraded samples and as complementary tool in paternity testing / Rui Pereira and Leonor Gusmão -- Capillary electrophoresis of an 11-plex mtDNA coding region SNP single base extension assay for discrimination of themost common caucasian HV1/HV2 mitotype / Peter M. Vallone -- Capillary electrophoresis of a multiplex reverse transcription-polymerase chain reaction to target messenger RNA markers for body fluid identification / Cordula Haas, Erin Hanson, and Jack Ballantyne -- DNA extraction from aged skeletal samples for STR typing by capillary electrophoresis / René Huel [and others] -- Interpretation guidelines for multilocus STR forensic profiles from low template DNA samples / Zoran M. Budimlija and Theresa A. Caragine -- Interpretation guidelines for mixed-STR multilocus electrophoretic profiles / Juan Antonio Luque -- Capillary electrophoresis analysis of a 9-plex STR assay for canine genotyping / Barbara van Asch and António Amorim -- Capillary electrophoresis of DNA from Cannabis sativa for correlation of samples to geographic origin / Heather Mller Coyle -- Capillary electrophoresis of multigene barcoding chloroplast markers for species identification of botanical trace evidence / Gianmarco Ferri, Beatrice Corradini, and Milena Alù -- Capillary electrophoresis of big-dye terminator sequencing reactions for human mtDNA control region haplotyping in the identification of human remains / Marta Montesino and Lourdes Prieto -- Capillary electrophoresis of human mtDNA control region sequences from highly degraded samples using short mtDNA amplicons / Odile M. Loreille and Jodi A. Irwin -- Interpretation guidelines of mt DNA control region sequence electropherograms in forensic gnetics / Manuel Crespillo Marquez -- Capillary electrophoresis of mtDNA cytochrome b gene sequences for animal species identification / Adrian Linacre -- Sequence analysis of the canine mitochondrial DNA control region from shed hair samples in criminal investigations / C. Berger, B. Berger, and W. Parson -- Integrated sample cleanup and microchip capillary array electrophoresis for high-performance forensic STR profiling / Peng Liu [and others] -- Microchip capillary electrophoresis protocol to evaluate quality and quantity of mtDNA amplified fragments for DNA sequencing in forensic genetics / Coro Fernández and Antonio Alonso -- Microchip capillary electrophoresis of multi-locus VNTR analysis for genotyping of Bacillus anthracis and Yersinia pestis in microbial forensic cases / Andrea Ciammaruconi.
  • 2013 Springer
    Spies, Maria.
    Also available: Print – 2013
  • 2005 CRCnetBASE
    Esteller, Manel.
  • 2009 Springer Protocols
    Tost, Jörg.
    DNA methylation : an introduction to the biology and the disease-associated changes of a promising biomarker / Jörg Tost -- Quantification of global DNA methylation by capillary electophoresis and mass spectrometry / Maria Berdasco, Mrio F. Fraga, and Manel Esteller -- Methyl group acceptance assay for the determination of global DNA methylation levels / Kenneth P. Nephew, Curt Balch, and David G. Skalnik -- Immunodetection array / Johannes Pröll ... [et al.] -- Methylated DNA immunoprecipitation (MeDIP) / Fabio Mohn ... [et al.] -- The MIRA method for DNA methylation analysis / Tibor A. Rauch and Gerd P. Pfeifer -- The HELP assay / Mayumi Oda and John M. Greally -- Differential methylation hybridization : profiling DNA methylation with a high-density CpG island microarray / Pearlly S. Yan ... [et al.] -- Analysis of DNA methylation by amplification of intermethylated sites (AIMS) / Mireia Jordà ... [et al.] -- Methylation-sensitive representational difference analysis (MS-RDA) / Toshikazu Ushijima and Satoshi Yamashita -- Restriction landmark genomic scanning : analysis of CpG islands in genomes by 2D gel elctrophoresis / Joseph F. Costello ... [et al.] -- GoldenGate assay for DNA methylation profiling / Marina Bibikova and Jian-Bing Fan -- 5'-azacytidine expression arrays / Paul Cairns -- DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones / Yingying Zhang ... [et al.] -- Identification and quantification of differentially methylated loci by the Pyrosequencing technology / Emelyne Dejeux ... [et al.] -- Mass spectrometric analysis of cytosine methylation by base-specific cleavage and primer extension methods / Dirk van den Boom and Mathias Ehrich -- Melting curve assays for DNA methylation analysis / Tomasz K. Wojdacz and Alexander Dobrovic -- Methylatioin SNaPshot : a method for the quantification of site-specific DNA methylation levels / Zachary Kaminsky and Arturas Petronis -- Bio-COBRA : absolute quantification of DNA methylation in electrofluidics chips / Romulo Martin Brena and Christoph Plass -- Restriction digestion and real-time PCR (qAMP) / Christopher C. Oakes ... [et al.] -- MethylQuant : a real-time PCR-based method to quantify DNA methylation at single specific cytosines / Claire Dugast-Darzacq and Thierry Grange -- Methylation-specific PCR / Julien D.F. Licchesi and James G. Herman -- MethyLight / Mihaela Campan ... [et al.] -- Quantification of methylated DNA by HeavyMethyl duplex PCR / Jürgen Distler -- Analysis of methylated circulating DNA in cancer patients' blood / Eiji Sunami ... [et al.] -- Prevention of PCR cross-contamination by UNG treatment of bisulfite-treated DNA / Reimo Tetzner -- Profiling DNA methylation from small amounts of genomic DNA starting material : efficient sodium bisulfite conversion and subsequent whole-genome amplification / Jonathan Mill and Arturas Petronis.
  • 2005 Springer
    Szyf, Moshe.
    DNA methylation : three decades in search of function / Aharon Razin -- Epigenetic mechanisms of gene regulation : relationships between DNA methylation, histone modification, and chromatin structure / Keith D. Robertson -- DNA hypo- vs. hypermethylation in cancer : tumor specificity, tumor progression, and therapeutic implications / Melanie Ehrlich and Guanchao Jiang -- DNA methylation in urological cancers / Wolfgang A. Schulz and Hans-Helge Seifert -- DNA methylation in colorectal cancer / Jeremy R. Jass ... [et al.] -- CpG island hypermethylation of tumor suppressor genes in human cancer : concepts, methodologies and uses / Michel Herranz and Manel Esteller -- The loss of methyl groups in DNA of tumor cells and tissues : the immunochemical approach / Alain Niveleau ... [et al.] -- Identifying clinicopathological association of DNA hypermethylation in cancers using CpG island microarrays / Susan H. Wei ... [et al.] -- Methylation analysis in cancer : (epi)genomic fast track from discovery to clinical routine / Carolina Haefliger, Sabine Maier and Alexander Olek -- Regulation of DNA methyltransferases in cancer / Nancy Detich and Moshe Szyf -- Inhibition of poly(ADP-ribosyl)ation allows DNA hypermethylation / Anna Reale ... [et al.] -- The role of active demethylation in cancer and its therapeutic potential / Moshe Szyf ... [et al.] -- Purine analogues and their role in methylation and cancer chemotherapy / Katherine L. Seley and Sylvester L. Mosley -- DNA methyltransferase inhibitors : paving the way for epigenetic cancer therapeutics / Gregory K. Reid and A. Robert MacLeod -- Preclinical and clinical studies on 5-aza-2'-deoxycytidine, a potent inhibitor of DNA methylation, in cancer therapy / Richard L. Momparler -- Anticancer gene therapy by in vivo DNA electrotransfer of MBD2 antisense / Pascal Bigey and Daniel Scherman.
  • 2006 Springer
    Böhm, P.; Doerfler, Walter.
    Also available: Print – 2006
  • 2006 Springer
    Böhm, P.; Doerfler, Walter.
    Regulation of chromatin and DNA-methylation patterns in blood cell development / C. Bonifer, P. Lefevre, and H. Tagoh -- Methylation dynamics in the early mammalian embryo : implications of genome reprogramming defects for development / T. Haaf -- Epigenetic regulation in drosophila / F. Lyko ... [et.al.] -- Epimutations in human disease / B. Horsthemke -- Epigenotypes of latent herpesvirus genomes / J. Minarovits -- Epigenetics of complex diseases : from general theory to laboratory experiments / A. Schumacher and A. Petronis -- MSL proteins and the regulation of gene expression / S. Rea and A. Akhtar -- DNA methylation profiles of female steroid hormone-driven human malignancies / M. Campan, D.J. Weisenberger, and P.W. Laird -- Genome-wide analysis of DNA methylation changes in human malignancies / C. Plass and D.J. Smiraglia -- Decreased fidelity in replicating DNA methylation patterns in cancer cells leads to dense methylation of a CpG island / N. Watanabe ... [et.al.] -- Methylation of endogenous human retroelements in health and disease / W. A. Schulz, C. Steinhoff, and A.R. Florl -- Cancer-linked DNA hypomethylation and its relationship to hypermethylation / M. Ehrlich.
    Also available: Print – 2006
  • 2005 Springer
    Esteller, Manel.
  • 2008 CRCnetBASE
    Wang, Sun-Chong; Petronis, Arturas.
  • 2011
    Kobayashi, Yuya; Brooks, James D.; Lipsick, Joseph Steven; Myers, Richard; Sherlock, Gavin; Tang, Hua.
    Candidate gene based studies have identified a handful of aberrant CpG DNA methylation events in prostate cancer (Brooks et al. 1998; Yegnasubramanian et al. 2004). However, large scale DNA methylation profiles have not been examined for normal prostates or prostate tumors. Additionally, the mechanisms behind these DNA methylation alterations are unknown. In this thesis, I describe the results of my efforts to better understand these previously unexplored areas of biology. For the study presented in this thesis, I quantitatively profiled 95 primary prostate tumors and 86 healthy prostate tissue samples for their DNA methylation levels at 26,333 CpGs representing 14,104 gene promoters by using the Illumina HumanMethylation27 platform. When the profiles of the prostate tissue samples were compared, I observed a substantial number of tumor-specific DNA methylation alterations. A 2-class Significance Analysis of this dataset revealed 5,912 CpG sites with increased DNA methylation and 2,151 CpG sites with decreased DNA methylation in tumors (FDR < 0.8%). Prediction Analysis of this dataset identified 87 CpGs that are the most predictive diagnostic methylation biomarkers of prostate cancer. By integrating available clinical follow-up data, I also identified 69 prognostic DNA methylation alterations that correlate with biochemical recurrence of the tumor. To identify the mechanisms responsible for these genome-wide DNA methylation alterations, I measured the gene expression levels of several DNA methyltransferases (DNMTs) and their interacting proteins by TaqMan qPCR and observed increased expression of DNMT3A2, DNMT3B, and EZH2 in tumors. Subsequent transient transfection assays in cultured primary prostate cells revealed that DNMT3B1 and DNMT3B2 overexpression resulted in increased methylation of a substantial subset of CpG sites that also showed tumor-specific increased methylation.
  • 2006 CRCnetBASE
    Allison, David B.
    Also available: Print – 2006
  • pt. A-B, 2006. ScienceDirect
    pt. B ScienceDirect
    Kimmel, Alan R.; Oliver, B.
    Pt. A. Array platforms and wet-bench protocols -- pt. B. Databases and statistics.
    Also available: Print – pt. A-B, 2006.
  • 2011 Springer Protocols
    Samori', B.; Zuccheri, Giampaolo.
    Synthesis and characterization of self-assembled DNA nanostructures / Chenxiang Lin [and others] -- Protocols for self-assembly and imaging of DNA nanostructures / Thomas L. Sobey and Friedrich C. Simmel -- Self-assembly of metal-DNA triangles and DNA nanotubes with synthetic junctions / Hua Yang [and others] -- DNA-templated Pd conductive metallic nanowires / Khoa Nguyen, Stephane Campidelli, and Arianna Filoramo -- Method to map spatiotemporal pH changes inside living cells using a pH-triggered DNA nanoswitch / Souvik Modi and Yamuna Krishnan -- Control of helical handedness in DNA and PNA nanostructures / Roberto Corradini [and others] -- G-quartet, G-quadruplex, and G-wire regulated by chemical stimuli / Daisuke Miyoshi and Naoki Sugimoto -- Preparation and atomic force microscopy of quadruplex DNA / James Vesenka -- Synthesis of long DNA-based nanowires / Alexander Kotlyar -- G-wire synthesis and modification with gold nanoparticle / Christian Leiterer, Andrea Csaki, and Wolfgang Fritzsche -- Preparation of DNA nanostructures with repetitive binding motifs by rolling circle amplification / Edda Rei⁷, Ralph Holzel, and Frank F. Bier -- Controlled confinement of DNA at the nanoscale : nanofabrication and surface bio-functionalization / Matteo Palma [and others] -- Templated assembly of DNA origami gold nanoparticle arrays on lithographically patterned surfaces / Albert M. Hung and Jennifer N. Cha -- DNA-modified single crystal and nanoporous silicon / Andrew Houlton [and others] -- Atomic force microscopy as a lithographic tool : nanografting of DNA nanostructures for biosensing applications / Matteo Castronovo and Denis Scaini -- Trapping and immobilization of DNA molecules between nanoelectrodes / Anton Kuzyk, J. Jussi Toppari, and Paivi Torma -- DNA contour length measurements as a tool for the structural analysis of DNA and nucleoprotein complexes / Claudio Rivetti -- DNA molecular handles for single-molecule protein-folding studies by optical tweezers / Ciro Cecconi [and others] -- Optimal practices for surface-tethered single molecule total internal reflection fluorescence resonance energy transfer analysis / Matt V. Fagerburg and Sanford H. Leuba -- Engineering mononucleosomes for single-pair FRET experiments / Wiepke J.A. Koopmans, Ruth Buning, and John van Noort -- Measuring DNA-protein binding affinity on a single molecule using optical tweezers / Micah J. McCauley and Mark C. Williams -- Modeling nanopores for sequencing DNA / Jeffrey R. Comer, David B. Wells, and Aleksei Aksimentiev.
  • 2011 Springer Protocols
    Tsubouchi, Hideo.
    Methods to study mitotic homologous recombination and genome stability / Xiuzhong Zheng, Anastasiya Epstein, and Hannah L. Klein -- Characterizing resection at random and unique chromosome double-strand breaks and telomere ends / Wenjian Ma [and others] -- Characterization of meiotic recombination initiation sites using pulsed-field gel electrophoresis / Sarah Farmer, Wing-Kit Leung, and Hideo Tsubouchi -- Genome-wide detection of meiotic DNA double-strand break hotspots using single-stranded DNA / Hannah G. Blitzblau and Andreas Hochwagen -- Detection of covalent DNA-bound Spo11 and topoisomerase complexes / Edgar Hartsuiker -- Molecular assays to investigate chromatin changes during DNA double-strand break repair in yeast / Scott Houghtaling, Toyoko Tsukuda, and Mary Ann Osley -- Analysis of meiotic recombination intermediates by two-dimensional gel electrophoresis / Jasvinder S. Ahuja and G. Valentin Borner -- Mapping of crossover sites using DNA microarrays / Stacy Y. Chen and Jennifer C. Fung -- Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1 / Hsiao-Chi Lo and Nancy M. Hollingsworth -- Genetic and molecular analysis of mitotic recombination in Saccharomyces cerevisiae / Belen Gomez-Gonzalez, Jose F. Ruiz, and Andres Aguilera -- In vivo site-specific mutagenesis and gene collage using the delitto perfetto system in yeast Saccharomyces cerevisiae / Samantha Stuckey, Kuntal Mukherjee, and Francesca Storici -- Detection of RNA-templated double-strand break repair in yeast / Ying Shen and Francesca Storici -- SNP-Based Mapping of crossover recombination in Caenorhabditis elegans / Grace C. Bazan and Kenneth J. Hillers -- Characterization of meiotic crossovers in pollen from Arabidopsis thaliana / Jan Drouaud and Christine Mezard -- Isolation of meiotic recombinants from mouse sperm / Francesca Cole and Maria Jasin -- Homologous recombination assay for interstrand cross-link repair / Koji Nakanishi [and others] -- Evaluation of homologous recombinational repair in chicken B lymphoma cell line, DT40 / Hiroyuki Kitao, Seiki Hirano, and Minoru Takata -- Understanding the immunoglobulin locus specificity of hypermutation / Vera Batrak, Artem Blagodatski, and Jean-Marie Buerstedde -- Quality control of purified proteins involved in homologous recombination / Xiao-Ping Zhang and Wolf-Dietrich Heyer -- Assays for structure-selective DNA endonucleases / William D. Wright, Kirk T. Ehmsen, and Wolf-Dietrich Heyer -- In vitro assays for DNA pairing and recombination-associated DNA synthesis / Jie Liu, Jessica Sneeden, and Wolf-Dietrich Heyer -- In vitro assay for monitoring the formation and branch migration of holliday junctions mediated by a eukaryotic recombinase / Yasuto Murayama and Hiroshi Iwasaki -- Reconstituting the key steps of the DNA double-strand break repair in vitro / Matthew J. Rossi [and others] -- Biochemical studies on human Rad51-mediated homologous recombination / Youngho Kwon, Weixing Zhao, and Patrick Sung -- Studying DNA replication fork stability in xenopus egg extract / Yoshitami Hashimoto and Vincenzo Costanzo -- Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies / Ilya J. Finkelstein and Eric C. Greene -- FRET-based assays to monitor DNA binding and annealing by Rad52 recombination mediator protein / Jill M. Grimme and Maria Spies -- Visualization of human Dmc1 presynaptic filaments / Michael G. Sehorn and Hilarie A. Sehorn -- Tracking of single and multiple genomic loci in living yeast cells / Imen Lassadi and Kerstin Bystricky -- Cell biology of homologous recombination in yeast / Nadine Eckert-Boulet, Rodney Rothstein, and Michael Lisby -- Live cell imaging of meiotic chromosome dynamics in yeast / Harry Scherthan and Caroline Adelfalk -- Chromosome structure and homologous chromosome association during meiotic prophase in Caenorhabditis elegans / Kentaro Nabeshima.
  • v. 1-<2>, 1981-<83>
    Friedberg, Errol C.; Hanawalt, Philip C.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 Springer
    Balajee, Adayabalam S.
    Human premature aging disorders and dysfunction of DNA repair / Byungchan Ahn and Vilhelm A. Bohr -- DNA repair aspects for RecQ helicase disorders / Takehisa Matsumoto -- Trichothiodystrophy: a disorder highlighting the crosstalk between DNA repair and transcription / Miria Stefanini -- Roles of the BRCA1 and BRCA2 breast cancer susceptibility proteins in DNA repair / Katrin Gudmundsdottir, Emily Witt and Alan Ashworth -- Radiosensitivity of cells derived from Down syndrome patients: is defective DNA repair involved? / Adayapalam T. Natarajan -- The Fanconi anemia/BRCA pathway: FANCD2 at the crossroad between repair and checkpoint responses to DNA damage / Massimo Bogliolo and Jordi Surrallés -- Is ataxia telangiectasia a result of impaired coordination between DNA repair and cell cycle checkpoint regulators? / Adayabalam S. Balajee and Charles R. Geard -- Mechanisms of DNA damage and repair in Alzheimer disease / V. Prakash Reddy ... [et al.] -- Orchestration of telomeres and DNA repair factors in mammalian cells: implications for cancer and ageing / M. Prakash Hande -- Defective solar protection in xeroderma pigmentosum and Cockayne syndrome patients / Colette ApRhys and Daniel Judge.
    Also available: Print – 2006
  • 2012 ScienceDirect
    2012 ClinicalKey
    Kelley, Mark Richard.
    Introduction and overview of current targets: bench to clinic / Mark R. Kelley -- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu -- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto -- 4. PARP inhibitors -- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew -- 5. Inhibiting selective DNA polymerases for therapeutic intervention / Anthony J. Berdis -- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick -- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle -- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller -- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li -- 10. DNA repair signaling targets / Susan Ashwell -- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis -- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan -- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko -- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
  • 2013 Springer
    Cabarcas, Stephanie M.; Hurt, Elaine M.; Mathews, Lesley A.
    The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
  • pt. A-B, 2006. ScienceDirect
    pt. B ScienceDirect
    Campbell, Judith L.; Modrich, Paul.
    Also available: Print – pt. A-B, 2006.
  • 2005 Springer Protocols
    Henderson, Daryl S.
    Biochemical assays for the characterization of DNA helicases / Robert M. Brosh Jr. and Sudha Sharma -- Repair synthesis assay for nucleotide excision repair activity using fractionated cell extracts and UV-damaged plasmid DNA / Maureen Biggerstaff and Richard D. Wood -- Assaying for the dual incisions of nucleotide excision repair using DNA with a lesion at a specific site / Mahmud K.K. Shivji ... [et al.] -- Analysis of proliferating cell nuclear antigen (PCNA) associated with DNA excision repair sites in mammalian cells / A. Ivana Scovassi and Ennio Prosperi -- Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates / Jill A. Mello, Jonathan G. Moggs, and Geneviève Almouzni. Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage / Xuan Huang and Zbigniew Darzynkiewicz -- Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication) / Zbigniew Darzynkiewicz, Xuan Huang, and Masaki Okafuji -- In vitro rejoining of double-strand breaks in genomic DNA / George Iliakis and Nge Cheong -- Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR / Michael J. Villalobos, Christopher J. Betti, and Andrew T.M. Vaughan -- Plasmid-based assays for DN