BookTomoaki Shirao, Yuko Sekino, editors.
Summary: This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer's disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in various fields, including not only molecular biology, biophysics, cell biology, neuroscience, clinical studies, spermatogenesis, immunology, and cancer metastasis, but others as well. The structure of this book facilitates the understanding of the whole picture of studies on drebrin. The volume begins with a general introduction to drebrin, and then the chapters in the second part provide the basic knowledge for further understanding. The third part examines its function in the nervous system, and the fourth part discusses its function in the non-nervous system. This work will appeal to researchers who are interested in cytoskeletal dynamics at membrane-cytoskeletal interface as well as the number of them who use drebrin as a tool, such as a marker of synaptic function or a disease marker. This volume is kept as concise as possible in order to be understood by readers in diverse scientific disciplines"--Publisher's description.
Contents:
History of drebrin discovery as an general introduction. General introduction to drebrin / Tomoaki Shirao, Yuko Sekino
Basic information about drebrin. Molecular cloning of drebrin: progress and perspectives / Nobuhiko Kojima
Biochemistry of drebrin and its binding to actin filaments / Ryoki Ishikawa
Phosphorylation of drebrin and its role in neuritogenesis / Phillip R. Gordon-Weeks
Remodeling of actin filaments by drebrin a and its implications / Elena E. Grintsevich
Cell shape change by drebrin / Kensuke Hayashi
Drebrin in nervous system. Localization of drebrin: light microscopy study / Tomoaki Shirao, Noriko Koganezawa, Hiroyuki Yamazaki, Kenji Hanamura, Kazuyuki Imamura
Making of a synapse: recurrent roles of drebrin a at excitatory synapses throughout life / Chiye Aoki, Ang D. Sherpa
Drebrin in neuronal migration and axonal growth / Kenji Hanamura
Drebrin and spine formation / Hideto Takahashi, Yusuke Naito
Role of drebrin in synaptic plasticity / Yuko Sekino, Noriko Koganezawa, Toshiyuki Mizui, Tomoaki Shirao
Drebrin in Alzheimer's disease / Yuta Ishizuka, Kenji Hanamura
Drebrins and connexins: a biomedical perspective / Irina V. Majoul, Justus S. Ernesti, Eugenia V. Butkevich, Rainer Duden
Homer, spikar, and other drebrin-binding proteins in the brain / Hiroyuki Yamazaki, Tomoaki
Role of drebrin at the immunological synapse / Vera Rocha-Perugini, Mónica Gordon-Alonso, Francisco Sánchez-Madrid
Drebrin regulation of calcium signaling in immune cells / Jonathan Pabon, Man Kit Law, Avery August
Drebrin and spermatogenesis / Haiqi Chen, Michelle W.M. Li, C. Yan Cheng
Drebrin at junctional plaques / Wiebke K. Ludwig-Peitsch
Juxtanuclear drebrin-enriched zone / Wiebke K. Ludwig-Peitsch
Drebrin in renal glomeruli / Wiebke K. Ludwig-Peitsch.