BookMaria Gazouli, George E. Theodoropoulos, editors.
Summary: This book reviews recent knowledge of the role of stem cells in the gastrointestinal system. It covers extensive topics for each organ, including the pancreas, esophagus, liver, and colon, while also discussing the contributions of stem cells to therapeutic approaches toward gastrointestinal diseases, including inflammatory bowel diseases. Comprehensive and cutting-edge, Digestive System Diseases: Stem Cell Mechanisms and Therapies deepens a reader's theoretical expertise in gastrointestinal stem cell biology. It furthers scientists' understanding of gastrointestinal stem cells and, most importantly, the development of novel therapeutic targets. Graduate and postdoctoral students, medical doctors (including gastroenterologists and surgeons), and principal investigators in both academia and industry will benefit from this book. In particular, it is a valuable resource for professionals within the fields of gastrointestinal research, pharmaceutical science, molecular biology, regenerative medicine, and genetics.
Contents:
Intro; Preface; Digestive System Diseases: Stem Cell Mechanisms and Therapies; About the Editors; Contents; Introduction: Gastrointestinal Stem Cells in Human Health and Disease; References; Introduction to Stem Cell Principles and Biology; Embryonic Stem Cells (ESCs); Induced Pluripotent Stem Cells (iPSCs); Fetal Stem Cells (FSCs); Amniotic Fluid (AF); Umbilical Cord Blood; Stem Cells Derived from Extraembryonic Tissues; Amniotic Membrane (AM); Placenta; Adult Stem Cells; Hematopoietic Stem Cells (HSCs); Mesenchymal Stromal Cells (MSCs); Neural Stem Cells (NSCs) Activation of Gene Signalling Pathways Phenotypical Changes via Drug Resistance; Mechanisms Evade DNA Damage; Modification of Cell Cycle Phases; Therapeutic Potential of CSCs in Colorectal Cancer; Concluding Remarks; References; The Role of Stem Cells in the Treatment of Anal Fistulas; Introduction; Perianal Fistula; Stem Cell Properties; Techniques; Isolation of Stem Cells; Administration; Results; Conclusions; References; Stem Cells in Inflammatory Bowel Disease: From Pathogenesis to Clinical Practice; Introduction; Pathophysiology of GI SCs; Therapeutic Value of HSCs in IBD Neural Stem Cells in the Developing Brain Regenerative Medicine; Conclusion; References; The Truth Behind Esophagus: The Stem Cells' Significance; Introduction; Stem Cells Are the Main Factors of Esophageal Homeostasis; Stem Cells in Esophageal Cancer; Stem Cells in Novel Esophageal Therapeutic Attempts; Conclusion; References; Pancreatic Diseases: The Role of Stem Cells; The Role of Stem Cells in Pancreatic Cancer; Introduction; Cancer Stem Cells in Pancreatic Cancer; Clinical Significance of Pancreatic Cancer Stem Cells; The Role of Stem Cells in the Treatment of Pancreatic Cancer Paracrine Effect of Mesenchymal Stem/Stromal Cells in Liver DiseasesConclusion; References; The Role of Stem Cells in Colorectal Cancer Carcinogenesis and Treatment; Introduction; The Intestine and the Origin of Colorectal CSCs; Colorectal CSCs: Phenotypic and Functional Characterisation; Role of CSCs in the Pathogenesis of Colorectal Carcinoma; CSCs in Initiation of Colorectal Carcinoma; CSCs in Vasculature of Colorectal Carcinoma; CSCs in Metastasis in Colorectal Carcinoma; CSC in Escaping Apoptosis in Colorectal Carcinoma; Roles of CSCs in Colorectal Carcinoma Therapy Resistance The Use of Genetically Engineered Mesenchymal Stem Cells to Induce Tumor Apoptosis; The Use of Genetically Engineered Mesenchymal Stem Cells in Gene-Directed Enzyme Prodrug Therapy; The Role of Stem Cells in Acute and Chronic Pancreatitis; Introduction; Stem Cells in the Treatment of Acute Pancreatitis; Stem Cells in the Treatment of Chronic Pancreatitis; Current Limitations of Stem Cell-Based Therapies; References; Stem Cell Therapy for Liver Diseases; Stem Cell Categories for Liver Disease Therapy; Extrahepatic Adult Stem Cells; Liver-Derived Stem Cells; Stem Cell-Treated Liver Diseases