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  • Book
    Ling Zhang, Haipeng Shao, Serhan Alkan, editors.
    Summary: This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists.

    Contents:
    Intro
    Preface
    Contents
    Contributors
    1: Anatomy and Histology of Normal Liver and Spleen
    Spleen
    Anatomy
    Embryology
    Normal Function
    Imaging Findings
    Gross
    Microscopic Findings
    White Pulp
    Red Pulp
    Liver
    Anatomy
    Embryology
    Normal Function
    Imaging Findings
    Gross
    Microscopic Findings
    References
    2: Diagnostic Approaches to Hematopoietic Disorders of the Spleen and Liver
    Introduction
    Spleen
    Indications of Splenectomy
    Indications of Splenic Fine Needle Aspirate and Needle Core Biopsy
    Grossing
    Spleen from Splenectomy Splenic Biopsy
    Laparoscopic Splenectomy
    Sample Processing
    Microscopy
    Ancillary Studies
    Immunohistochemistry Study
    Flow Cytometry
    Liver
    Indications for Liver Biopsy
    Imaging Study
    Grossing
    Liver Biopsy
    Resection/Lobectomy
    Sample Processing
    Fixation, Routine, and Special Staining
    Microscopic Examination
    Ancillary Studies
    Flow Cytometry
    Immunohistochemistry Study
    References
    3: Molecular and Genetic Diagnostic Approaches of Hematopoietic Disorders of the Spleen and Liver
    Introduction
    Cytogenetics
    Conventional Karyotyping Fluorescence In Situ Hybridization (FISH)
    Cytogenetic Abnormalities Detectable by Conventional Karyotyping or FISH in Lymphomas
    Array-Based Comparative Genomic Hybridization (aCGH) and Single-Nucleotide Polymorphism (SNP) Array
    Polymerase Chain Reaction
    B- and T-Cell Receptor Studies
    Sanger Sequencing
    Next-Generation Sequencing
    Genetic Mutations in Splenic and Hepatic Lymphomas
    References
    4: Hairy Cell Leukemia, Hairy Cell Leukemia Variant, and Splenic Diffuse Red Pulp Small B-Cell Lymphoma
    Introduction
    Hairy Cell Leukemia
    Definition
    Cell Origin Epidemiology
    Etiology and Pathogenesis
    Clinical Presentations
    Morphology
    Gross Features
    Microscopic Features
    Peripheral Blood
    Bone Marrow
    Spleen, Liver, and Lymph Nodes
    Cytochemical Findings and Immunophenotyping
    Cytogenetics
    Molecular Findings
    Differential Diagnosis
    Hairy Cell Leukemia Variant (HCL-V)
    Splenic Marginal Zone Lymphoma (SMZL)
    Mantle Cell Lymphoma
    Chronic Lymphocytic Leukemia (CLL)
    Splenic Diffuse Red Pulp Small B-Cell Lymphoma (SDRPL)
    Aplastic Anemia
    Prognosis and Treatment
    Diagnostic Caveats Splenic B-Cell Lymphoma/Leukemia, Unclassifiable
    Hairy Cell Leukemia, Variant
    Etiology and Pathogenesis
    Epidemiology
    Clinical Presentations
    Morphology
    Cytochemical Findings and Immunophenotyping
    Cytogenetics and Molecular Findings
    Differential Diagnosis
    Hairy Cell Leukemia (HCL)
    Splenic Marginal Zone Lymphoma (SMZL)
    Splenic Diffuse Red Pulp Small B-cell Lymphoma (SDRPL)
    Treatment
    Splenic Diffuse Red Pulp Small B-Cell Lymphoma (SDRPL)
    Etiology and Pathogenesis
    Epidemiology
    Clinical Presentations
    Morphology
    Digital Access Springer 2020