BookLing Zhang, Haipeng Shao, Serhan Alkan, editors.
Summary: This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists.
Contents:
Intro
Preface
Contents
Contributors
1: Anatomy and Histology of Normal Liver and Spleen
Spleen
Anatomy
Embryology
Normal Function
Imaging Findings
Gross
Microscopic Findings
White Pulp
Red Pulp
Liver
Anatomy
Embryology
Normal Function
Imaging Findings
Gross
Microscopic Findings
References
2: Diagnostic Approaches to Hematopoietic Disorders of the Spleen and Liver
Introduction
Spleen
Indications of Splenectomy
Indications of Splenic Fine Needle Aspirate and Needle Core Biopsy
Grossing
Spleen from Splenectomy Splenic Biopsy
Laparoscopic Splenectomy
Sample Processing
Microscopy
Ancillary Studies
Immunohistochemistry Study
Flow Cytometry
Liver
Indications for Liver Biopsy
Imaging Study
Grossing
Liver Biopsy
Resection/Lobectomy
Sample Processing
Fixation, Routine, and Special Staining
Microscopic Examination
Ancillary Studies
Flow Cytometry
Immunohistochemistry Study
References
3: Molecular and Genetic Diagnostic Approaches of Hematopoietic Disorders of the Spleen and Liver
Introduction
Cytogenetics
Conventional Karyotyping Fluorescence In Situ Hybridization (FISH)
Cytogenetic Abnormalities Detectable by Conventional Karyotyping or FISH in Lymphomas
Array-Based Comparative Genomic Hybridization (aCGH) and Single-Nucleotide Polymorphism (SNP) Array
Polymerase Chain Reaction
B- and T-Cell Receptor Studies
Sanger Sequencing
Next-Generation Sequencing
Genetic Mutations in Splenic and Hepatic Lymphomas
References
4: Hairy Cell Leukemia, Hairy Cell Leukemia Variant, and Splenic Diffuse Red Pulp Small B-Cell Lymphoma
Introduction
Hairy Cell Leukemia
Definition
Cell Origin Epidemiology
Etiology and Pathogenesis
Clinical Presentations
Morphology
Gross Features
Microscopic Features
Peripheral Blood
Bone Marrow
Spleen, Liver, and Lymph Nodes
Cytochemical Findings and Immunophenotyping
Cytogenetics
Molecular Findings
Differential Diagnosis
Hairy Cell Leukemia Variant (HCL-V)
Splenic Marginal Zone Lymphoma (SMZL)
Mantle Cell Lymphoma
Chronic Lymphocytic Leukemia (CLL)
Splenic Diffuse Red Pulp Small B-Cell Lymphoma (SDRPL)
Aplastic Anemia
Prognosis and Treatment
Diagnostic Caveats Splenic B-Cell Lymphoma/Leukemia, Unclassifiable
Hairy Cell Leukemia, Variant
Etiology and Pathogenesis
Epidemiology
Clinical Presentations
Morphology
Cytochemical Findings and Immunophenotyping
Cytogenetics and Molecular Findings
Differential Diagnosis
Hairy Cell Leukemia (HCL)
Splenic Marginal Zone Lymphoma (SMZL)
Splenic Diffuse Red Pulp Small B-cell Lymphoma (SDRPL)
Treatment
Splenic Diffuse Red Pulp Small B-Cell Lymphoma (SDRPL)
Etiology and Pathogenesis
Epidemiology
Clinical Presentations
Morphology