BookJayvadan K. Patel, Vijaykumar Sutariya, Jagat Rakesh Kanwar, Yashwant V. Pathak, editors.
Summary: This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
Contents:
Intro; Foreword; Preface; Contents; Contributors; Part I: Introduction and Basic Concept of Drug Delivery for Retina and Posterior Segment Disease;
Chapter 1: Anatomy and Physiology of Retina and Posterior Segment of the Eye; Introduction; Sensory Retina; Foveal Cytoarchitecture; Synaptic Connectivity; Uveal Arterial Circulation; Development and Anatomy of the Central Retinal Artery; Barrier System of the Retina; Optic Disc and Cup; Laminar Organization of the Optic Disc; Prelaminar Part; Laminar Region; Postlaminar Region; Myelination of the Ganglionic Axons
Chapter 3: Drug Delivery to Posterior Segment of the Eye: Conventional Delivery Strategies, Their Barriers, and RestrictionsIntroduction; Posterior Segment of the Eye; Drug Delivery Strategies for Posterior Eye, Their Barriers, and Restrictions; Topical Drug Application; Systemic Drug Delivery; Intravitreal Route; Periocular Route or Transscleral Diffusion; Transscleral Iontophoresis; Ocular Implants; References;
Chapter 4: Penetration Routes to Retina and Posterior Segment; Introduction; Systemic Route; Topical Route; Periocular and Suprachoroidal Routes; Intraocular Routes; Conclusion Metabolic Activity of the RPE and the PhotoreceptorsModulatory and Protective Role of the RPE; Optic and Non-optic Retina; Physiologic Properties of the Photoreceptors; Retinal Pathways and Synaptic Integration; Pupillary Light Reflex and Circadian Rhythm; Conclusions; References;
Chapter 2: Pharmacotherapy of Diabetic Macular Edema and Retinopathy; Introduction; Diabetic Retinopathy; Characteristics of Diagnosis; Treatments and Therapy; Diabetic Macular Edema; Characteristics of Diagnosis; Treatments and Therapy; Conclusion; Future Trends; References Specific Anti-VEGF DrugsOther Methods of Treatment; Routes of Drug Delivery; Conclusion; References; Part II: Nanotechnology Based Formulations for Retina and Posterior Segment Disease;
Chapter 6: Liposomes for Retina and Posterior Segment Disease; Introduction; Liposomes; Drug Loading; Drug Delivery; Targeted Drug Delivery; Application in Ocular Drug Delivery; Role of Surface Charge and Vesicle Type in Liposome-Corneal Interaction; Passive Targeting Drug-Encapsulated Liposomes; Low Molecular Weight Chitosan-Coated Liposomes