Books

Summary: In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient outcomes. Individual chapters are devoted to particular tumor types and subtypes, and all aspects of transplantation for patients with T cell and NK cell lymphomas are discussed. As such, the book offers a valuable resource for hematologists, oncologists, hematopathologists, and all those seeking an up-to-date overview of how new, targeted therapies are delivering better disease control and improved quality of life.

Contents:
1. Epidemiology and pathology of T- and NK-cell lymphomas
2. Molecular and genomic landscape of peripheral T-cell lymphoma
3. Tumor microenvironment in T-cell lymphomas
4. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)
5. Angioimmunoblastic T-cell lymphoma
6. Anaplastic large cell lymphoma: contemporary concepts and optimal management
7. Adult T-cell leukemia-lymphoma
8. NK-cell lymphomas
9. Hepatosplenic T-cell lymphomas
10. Rare T-cell subtypes
11. Primary cutaneous T-cell lymphomas: mycosis fungoides and Sezary syndrome
12. CD30-positive lymphoproliferative disorders
13. Transplantation.

Contents:
200 million thymocytes and I: A beginner's survival guide to t cell development
Development of [gamma][delta] T cells, the special-force soldiers of the immune system
Genetic tools to study T cell development
Assessment of T cell development by flow cytometry
Flow cytometry analysis of thymic epithelial cells and their subpopulations
Identifying the spatial relationships of thymic stromal and thymocyte subsets by immunofluorescence analysis
Purification of thymocyte and T cell subsets
Retroviral transduction of T cells and T cell precursors
Bone marrow and fetal liver radiation chimeras
In vitro analyses of T cell effector differentiation
Studying T cell development in thymic slices
FTOC-based analysis of negative selection
Reconstituted thymus organ culture
Induction of T cell development in vitro by delta-like (Dll)-expressing stromal cells
In vitro analysis of thymocyte signaling
Molecular analysis of mouse T cell receptor [alpha] and [beta] gene rearrangements
Intrathymic injection
Analysis of cell proliferation and homeostasis using EdU labeling
Characterization and isolation of human T cell progenitors
Approaches to study human T cell development
Humanized mice to study human T cell development
Using the zebrafish model to study T cell development.

Contents:
Overview of orchestration of CD4+ T cell subsets in immune responses
Th1/Th2 cell differentiation and molecular signals
Th1/Th2 cell?s function in immune system
Regulatory T Cell differentiation and their function in immune regulation
Th17 differentiation and their pro-inflammation function
Tfh Cell differentiation and their function in promoting B cell responses
Differentiation, Regulation and Function of Th9 Cell
The biology and functions of Th22 cell.

Contents:
Isolation of T cells from the skin / Beate Lorenz and Esther von Stebut
Isolation of leukocytes from mouse central nervous system / Iva Lelios and Melanie Greter
Isolation of T cells from the gut / Sonja Reissig, Christopher Hackenbruch, and Nadine Hövelmeyer
T cell isolation from mouse kidneys/ Isis Ludwig-Portugall and Christian Kurts
Intracellular staining for cytokines and transcription factors / Florian Mair and Vinko Tosevski
Tracking cells and monitoring proliferation / Vinko Tosevski and Florian Mair
Mass cytometry analysis of human T cell phenotype and function / Evan W. Newell and Lai Li Yun
Detection of NF-[kappa]B pathway activation in T helper cells / Oliver Gorka, Stefan Wanninger, and Jürgen Ruland
Assessing the suppressive activity of Foxp3⁺ regulatory T cells / Christian Thomas Mayer and Tim Sparwasser
In vitro generation of microbe-specific human Th17 cells / Julia M. Braun and Christina E. Zielinski
In vitro polarization of T-helper cells / Julie Rumble and Benjamin M. Segal
A method for the generation of TCR retrogenic mice / Elisa Kieback, Ellen Hilgenberg, and Simon Fillatreau
Mouse models of allergic airway disease / Helen Meyer-Martin, Sebastian Reuter, and Christian Taube
Induction of colitis in mice (T-cell transfer model) / Benno Weigmann
Manipulation of T cell function and conditional gene targeting in T cells / Anna Śledzińska,Lynsey Fairbairn, and Thorsten Buch
Aldara-induced psoriasis-like skin inflammation : Isolation and characterization of cutaneous dendritic cells and innate lymphocytes / C.T. Wohn ... [et al.]
Induction of passive EAE using myelin-reactive CD4+ T cells / Rhoanne C. McPherson ... [et al.]
Experimental mouse models of T cell-dependent inflammatory bowel disease / George X. Song-Zhao and Kevin J. Maloy
Analysis of chromosomal aberrations in murine HCC / Kristian Unger and Mathias Heikenwälder.

Summary: This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.

Summary: This book addresses one of the major challenges of immunology today that is being directed to the translation of the rapidly emerging volume of basic science contributions of immunology to clinical medicine. In so doing, the book systemically introduces and discusses concepts, classifications, phenotypic and functional descriptions of regulatory T (Treg) cells in health and disease. The authors of the 15 chapters were selected from among the most qualified experts in the field of Treg cell research who provide a comprehensive overview of Treg cells and their biology in the ensuing chapters. The beginning chapters provide a useful contemporary classification of Treg cell populations and then progress to chapters that explore basic mechanisms of Treg cell function and epigenetic control. In addition to descriptions of typical CD4+ Foxp3+ cells, other chapters provide detailed presentations of Treg subsets such as CD8+ Tregs and IL-10-producing Tr1 cells. The differences of various Treg subsets, as well as circulating and resident Treg cell populations, are next compared. Importantly, the next chapters provide the clinical correlation of Treg cells with autoimmune diseases, inflammatory diseases, metabolic diseases, cancer and organ transplantation and progress to chapters that highlight emerging innovative technology including nanoparticle-Treg cells and their translational values. In summary, the book will provide a valuable resource not only for graduate students and researchers in the fields of immunology, cell biology and translational medicine but also for all others interested in learning more about Treg cells and their application in human health and disease.

Summary: This book details the advances in cardiac MRI that have enabled quantitative tissue characterization of the myocardium using myocardial and blood T1 measurements, which have enabled reliable detection of diffuse pathological processes in both the cardiomyocytes and the interstitial cells of the myocardium. Evaluation of the native myocardial and interstitial fibrosis, and measurement of the extracellular volume fraction has allowed an unprecedented opportunity to elucidate the pathology, diagnosis and prognosis of cardiovascular disease. T1-Mapping in Myocardial Disease: Principles and Applications reviews a wide spectrum of significant cardiovascular disease and provides relevant guidance for the clinical implementation of this innovative technique. The specific topics covered include principles of T1-mapping in cardiovascular disease and the role of T1-mapping in hypertensive heart disease and hypertrophic cardiomyopathy, cardiotoxicity from cancer treatment, cardiacfibrosis, left ventricular hypertrophy in aortic stenosis, peri-infarct injury in ischemic cardiomyopathy, and stem cell therapy. This comprehensive coverage of the utility of T1-mapping in cardiovascular diseases will greatly appeal to the entire cardiovascular medicine and imaging communities.

Contents:
I. Geistes-, Nerven-, Augen-, Ohren-, Herz- und Gefässerkrankungen sowie Verdauungsstörungen infolge Tabakmissbrauchs
II. Der Tabak in gewerbehygienischer Bezichung.

Contents:
Growth and development
The orthopaedic history
The orthopaedic examination : a comprehensive overview
The orthopaedic examination : clinical application
Gait analysis
The limping child
Back pain
Disorders of the neck
Scoliosis
Kyphosis
Other anatomic disorders of the spine
Disorders of the upper extremity
Developmental dysplasia of the hip
Legg-calvé-perthes disease
Slipped capital femoral epiphysis
Congenital coxa vara
Disorders of the femur
Disorders of the leg
Disorders of the foot
Limb length discrepancy
Limb deficiencies
Arthritis
Infections of the musculoskeletal system
General principles of tumor management
Benign musculoskeletal tumors
Malignant bone tumors
General principles of managing orthopaedic injuries
Spinal injuries
Upper extremity injuries
Lower extremity injuries
Disorders of the brain
Disorders of the spinal cord
Poliomyelitis
Disorders of the peripheral nervous system
Muscle diseases
Skeletal dysplasias
Orthopaedic-related syndromes
Metabolic and endocrine disorders of bone
Hematologic disorders
Pediatric sports medicine : issues in contemporary sports participation.

Summary: This state-of-the-art book brings together the full range of issues that can inform care for patients experiencing the effects of concussion. Written by an international panel of experts and edited by a critical care physician and by a cognitive neuroscientist, the book serves as a primer of the various domains of study and application, while providing clinical insights and evidence to bring towards treatment. Chapters span the basic mechanics and pathophysiology of concussion, through its assessment, management, and complications. Comprehensive and timely, this book is accessible to healthcare professionals, and researchers eager to learn something about this field.

Contents:
Concussion Mechanism: Biomechanical Perspectives
The Pathophysiology of Concussion
Neuroimaging of Concussion
The Path Toward a Blood Test for Concussion : A Review of Biofluid Biomarkers for Concussive and Subconcussive Brain Trauma
Sport-related Concussion Guideline Development: Acute Management to Return-to-activity
Concussion Evaluation and Neurocognitive Outcomes
Psychological and Mental Health Sequelae of Concussion: Prevalence, Treatment Recommendations, Novel Biomarkers, and Diagnostic Challenges
Management of Concussion and Prolonged Symptoms Post Concussion
Neuroprotective Pharmacological Antioxidant Therapies for Concussions
Sex, Gender and Concussion
Chronic Traumatic Encephalopathy.

Summary: "We have a geographically diverse collection of authors who have helped us to present the most important topics in TIVA in a clear and easily readable style. Our vision is to empower readers to start or continue using this technique. Ideally this should be in young, healthy patients undergoing relatively straightforward surgery without the use of muscle relaxants"-- Provided by publisher.

Summary: This practical, insightful title is a must read for anyone interested in or recently appointed to a leadership role in an academic medical center. Taking the Lead: A Guide for Emerging Leaders in Academic Medical Centers represents the highly accomplished authors more than 60 years of collective insights about leadership and leading effectively in an academic medical center environment. The authors present creative and highly applicable themes synthesized from their knowledge, career experiences, unique reflections, practice, mistakes, and observations of successful (and not so successful) leaders. The result is a book of leadership wisdom a wealth of ideas, concepts, and insights to inform the readers career journey and to become the best leader they can be. Organized in five parts, this work examines the successful leadership transition in the unique (and sometimes perplexing) academic medical center environment. Informal, conversational in tone, and often engagingly humorous, Taking the Lead: A Guide for Emerging Leaders in Academic Medical Centers represents a concise and invaluable introductory read for the next generation of leaders, as well as a helpful resource for experienced healthcare leaders.

Contents:
Chapter 1 . Introduction: Why You Should Read this Book
Part I: Leadership in the Academic Medical Center: Insights and Perspectives
Chapter 2. The Milieu of the Academic Medical Center
Chapter 3. Transitioning to Leadership in the Academic Medical Center: Conceptual Considerations
Chapter 4. Transitioning to Leadership in the Academic Medical Center: Practical Considerations.-mChapter 5. Strengths and Motivations of the Leader.-Chapter 6. The Work of Leading in the Academic Medical Center
Part II: Deciding About Decision-Making
Chapter 7. The Multiple Dimensions of Decision-Making in the Academic Medical Center
Chapter 8. Making Leadership Decisions versus Clinical Decisions
Chapter 9. Getting Comfortable with the "Limits" of Decision-Making
Chapter 10. Decisions about Your Academic Medical Center Career Trajectory
Part III: Its the Little (or not so little) Things
Chapter 11. Leading by Following
Chapter 12. Understanding (and Following) the Academic Medical Centers "Chain of Command"
Chapter 13. The Value of "Invisible" Leadership
Chapter 14. The Leaders Role in Academic Medical Center Philanthropy
Chapter 15. Accreditation: The Regulatory "Lifeblood" of the Academic Medical Center
Part IV: Leadership Challenges & Challenges to Leadership
Chapter 16. Leading Change in the Academic Medical Center
Chapter 17. Leading Conflict Resolution
Chapter 18. Crisis Leadership in the Academic Medical Center
Chapter 19. Betrayal: Such is the Life of a Leader
Part V: Epilogue
Chapter 20. You Cant Lead if You Dont Take Care of Yourself.

Contents:
Xanthomonas and the TAL effectors: nature's molecular biologist
TAL effector DNA-binding principles and specificity
The development of TALE nucleases for biotechnology
Online tools for TALEN design
Assembly of customized TAL effectors through advanced ultimate system
Engineering customized TALENs using the platinum gate TALEN kit
Design, assembly, and characterization of TALE-based transcriptional activators and repressors
A new approach to dissect nuclear organization: TALE-mediated genome visualization (TGV)
TALEN-induced translocations in human cells
Mutagenesis in newts: Protocol for Iberian ribbed newts
Targeted mutagenesis in Bombyx mori using TALENs
Geneknockout by targeted mutagenesis in a hemimetabolous insect, the two-spotted cricket Gryllus bimaculatus, using TALENs
Methods for talen evaluation, use, and mutation detection in the mosquito Aedes aegypti
Methods for TALEN-mediated genomic manipulations in drosophila
Targeted mutagenesis in zebrafish by TALENs
Mutagenesis in xenopus and zebrafish using TALENs
Genome editing in mice using TALE nucleases
Genome editing in rats using tale nucleases
Designer nuclease-mediated generation of knockout THP1 cells.

Contents:
Impact of host factors and comorbid conditions
Preoperative pulmonary assessment and management of pulmonary complications
Preoperative cardiac assessment and management of perioperative cardiac complications
Preoperative hematologic assessment and management of hematologic complications
Metabolic complications of urologic surgery
Anesthetic complications in urologic surgery
Infectious complications of urologic surgery
Classification of complications and assessment of quality of care
Complications of the incision and patient positioning
Management of vascular complications in urology
Management of bowel complications
Management of urinary fistula
Management of urine leak
Management of ureteral injury
Management of complications related to traumatic injuries
Urologic surgery in the obese
Urologic surgery in the pregnant patient
Management of complications of gender confirmation surgery
Complications of genitourinary surgery in the irradiated pelvis
Prostate biopsy complications
Complications of upper tract drainage
Complications of intravesical therapy
Complications of renal tissue ablation
Complications of prostate cryosurgical ablation
Complications of transurethral resection of bladder tumors
Complications of endoscopic procedures for benign prostatic hyperplasia
Complications of ureteroscopic surgery
Complications of percutaneous renal surgery
Complications of extracorporeal shock wave lithotripsy
Special considerations in laparoscopy
Special considerations in robot-assisted surgery
Complications of robotic-assisted laparoscopic radical prostatectomy
Complications of robotic pelvic floor reconstruction
Complications of laparoscopic/robotic nephrectomy and partial nephrectomy
Complications of robotic upper urinary tract reconstruction
Complications of robotic cystectomy
Complications of nephrectomy
Complications of open partial nephrectomy
Complications of adrenal surgery
Complications of lymphadenectomy
Complications of radical cystectomy and urinary diversion
Complications of radical retropubic prostatectomy
Complications of ureteral reconstructive surgery
Complications of renal transplantation
Complications of conduit urinary diversion
Complications of continent cutaneous diversion
Complications of orthotopic neobladder
Complications of bladder augmentation and surgery for neurogenic bladder
Complications of female incontinence surgery
Complications of surgery for male incontinence
Complications of urethral reconstruction
Complications of surgery for erectile dysfunction and peyronie's disease
Complications of surgery of the testicle, vas deferens, epididymis, and scrotum
Special considerations in the pediatric patient
Complications of pediatric endoscopic surgery
Complications of pediatric laparoscopic and robotic surgery
Complications of surgery for posterior urethral valves
Complications of ureteral reimplantation, antireflux surgery, and megaureter repair
Complications of exstrophy and epispadias repair
Complications of hypospadias repair
Complications of surgery for disorders of sex development
Complications of pediatric urinary diversions and bladder augmentation.

Contents:
Introduction
Part I General Post-Mortem Processes: Degradation of Soft Tissue, Bone and Associated Materials
1 Gross Post-Mortem Changes in the Human Body
2 Microscopic Post-Mortem Changes: the Chemistry of Decomposition
3 Profiling Volatile Organic Compounds of Decomposition
4 Blood Degradation and Bloodstain Age Estimation
5 DNA Degradation: Current Knowledge and Progress in DNA Analysis
6 Taphonomic Alterations to Hair and Nail
7 Taphonomy of Teeth
8 The Taphonomy of Natural Mummies
9 Degradation of Clothing in Depositional Environments
10 Post-Mortem Interval Estimation: an Overview of Techniques
Part II The Depositional Environment
11 Relationships between Human Remains, Graves and the Depositional Environment
12 Bacterial Symbionts and Taphonomic Agents of Humans
13 Forensic Entomology and Funerary Archaeoentomology
14 Forensic Botany and Stomach Contents Analysis: Established Practice and Innovation
15 The Effects of Weathering on Bone Preservation
16 The Effects of Terrestrial Mammalian Scavenging and Avian Scavenging on the Body
17 Decomposition in Aquatic Environments
18 Post-Mortem Differential Preservation and its Utility in Interpreting Forensic and Archaeological Mass Burials
19 Reconstructing the Original Arrangement, Organisation and Architecture of Burials in Archaeology
Part III Anti-, Peri- and Post-Mortem Modifications to the Body
20 Forensic Toxicology of Decomposed Human Remains
21 Thermal Alteration to the Body
22 Concealing the Crime: the Effects of Chemicals on Human Tissues
23 Distinguishing between Peri- and Post-Mortem Trauma on Bone
24 Collection Care and Management of Human Remains
Part IV Case Studies
25 The Use of Volatile Fatty Acid Biomarkers to Estimate the Post-Mortem Interval
26 A Taphonomic Study Based on Observations of 196 Exhumations and 23 Clandestine Burials
27 Case Studies on Taphonomic Variation between Cemetery Burials
28 Forensic Entomology Case Studies from Mexico
29 Recovery of Skeletonised Human Remains and Textile Degradation: a Case Study
30 Saponified Brains of the Spanish Civil War
31 Analysis and Interpretation of Burned Human Remains from a Homicide
32 A Soldier's Story: Forensic Anthropology and Blast Injury
33 Decomposition in an Unusual Environment: Body Sealed in Concrete
34 A Case Study from Los Angeles: Baby in Concrete
Part V Past, Present and Future Considerations
35 History and Development of the First Anthropology Research Facility, Knoxville, Tennessee
36 Crime Scene Investigation, Archaeology and Taphonomy: Reconstructing Activities at Crime Scenes.

Summary: This book talks about developing and improvising upon medical presentations by equipping readers with critical technical tips and tricks to use popular presentation programs like PowerPoint or Keynote effectively. The book details numerous remedial measures for qualitative improvement of average medical presentations. It has three sections: first covers the general aspects of preparing a presentation; the second provides practical details and refinements of preparing a medical presentation; the last section deals with niceties of podium and webinar presentations. The chapters cover many serious mistakes and remedial measures to improve average medical presentations, such as a description of purposeful use of colors in a slide, a brief discourse on technicalities of appropriate clinical image formats for projection ensues; the use of drawing and photo-editing programs to inject excellence in the contents of a medical presentation to help it stand out in the crowd, details on the importance of lexical correctness- typography, line spacing and alignment to enhance the impact of the presented text and many more. Several short videos support and actively promote the viewpoints discussed in the text. This book elaborates on the exquisite art of creating remarkable medical presentations for a specialized audience. This book is a must-have for all healthcare professionals of all specialties and grades who make podium presentations in a medical conference webinar or submit posters for display.

Contents:
Philosophy of inception: Why a book on presentations
Optics of slide design & projection
Rational use of colour in presentations
Digital Imaging and formats
Supportive Apps
Background
The text slides
Data presentation: Use of tables and graphics
Use of photographs in medical presentations
Showing X-ray, MRI, CT, and Ultrasound images in presentations
Use of illustrations in medical presentations
Adding Videos in presentations
Posters for medical & scientific meetings
An approach to podium and webinar presentations
Audiovisual planning for a large medical conference.

Summary: This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes' avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.

Contents:
Intro; Preface; Contents;
Chapter 1: Protective Responses of Different Organs to Environmental Toxicants or Stresses; 1.1 Introduction; 1.2 Protective Responses to Environmental Toxicants or Stresses in the Intestine; 1.2.1 Superoxide Dismutase (SOD) Proteins; 1.2.2 MTL-1 and MTL-2; 1.2.3 Heat Shock Proteins (HSPs); 1.2.4 PMK-1, SKN-1/Nrf, and GST-4; 1.2.5 Transcriptional Factor DAF-16; 1.2.6 Antimicrobial Proteins; 1.2.7 Mitochondrial Unfolded Protein Response (UPR); 1.2.8 Endoplasmic Reticulum (ER) UPR; 1.2.9 Autophagy 1.3 Protective Responses to Environmental Toxicants or Stresses in Epidermis1.3.1 Antimicrobial Proteins; 1.3.2 Autophagy; 1.4 Protective Responses to Environmental Toxicants or Stresses in Neurons; 1.4.1 SKN-1/Nrf; 1.4.2 JNK Signaling; 1.4.3 ERK Signaling; 1.4.4 Antimicrobial Proteins; 1.4.5 Autophagy; 1.5 Protective Responses to Environmental Toxicants or Stresses in Muscle; 1.6 Perspectives; References;
Chapter 2: Avoidance Behavior of Nematodes to Environmental Toxicants or Stresses; 2.1 Introduction 2.2 Neurons Involved in the Regulation of Avoidance Behavior to Environmental Toxicants or Stress2.2.1 ASH Sensory Neurons; 2.2.1.1 Involvement of ASH Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.1.2 Molecular Basis for ASH Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.1.2.1 G Proteins; 2.2.1.2.2 Seven-Transmembrane Protein DCAR-1; 2.2.1.2.3 Neurotransmitter Signals; 2.2.2 ADL Sensory Neurons; 2.2.2.1 Involvement of ADL Sensory Neurons in Response to Environmental Toxicants or Stresses 2.2.2.2 Molecular Basis for ADL Sensory Neurons in Response to Environmental Toxicants or Stresses2.2.3 ASK Sensory Neurons; 2.2.4 ASJ Sensory Neurons; 2.2.4.1 Involvement of ASJ Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.4.2 Molecular Basis for ASJ Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.5 ADF Sensory Neurons; 2.2.6 ASI Sensory Neurons; 2.2.7 AWB Sensory Neurons; 2.2.8 AWC Sensory Neurons; 2.2.9 BAG Sensory Neurons; 2.2.9.1 Involvement of BAG Sensory Neurons in Response to Environmental Toxicants or Stresses 2.2.9.2 Molecular Basis for BAG Sensory Neurons in Response to Environmental Toxicants or Stresses2.2.10 OLL Sensory Neurons; 2.2.11 Interneurons; 2.3 Neuronal Circuit for the Avoidance Behavior to Environmental Toxicants or Stresses and the Underlying Molecular Basis; 2.3.1 ASI-ADF-ASH and ASH-RIC-ASI Neuronal Circuits; 2.3.1.1 ASI-ADF-ASH Neuronal Circuit; 2.3.1.2 ASH-RIC-ASI Neuronal Circuit; 2.3.1.3 Cross-Inhibitory Neural Circuitry Between ASHs and ASIs; 2.3.2 ADL-AIB Neuronal Circuit; 2.3.3 ASJ-RIM/RIC Neuronal Circuit; 2.3.4 AWB-AIZ/RMG Neuronal Circuit; 2.3.5 OLL-RMG Neuronal Circuit

Summary: The main objective of this book is to provide radiation oncologists with a clear, up-to-date guide to tumor delineation and contouring of organs at risk. With this in mind, a detailed overview of recent advances in imaging for radiation treatment planning is presented. Novel concepts for target volume delineation are explained, taking into account the innovations in imaging technology. Special attention is paid to the role of the newer imaging modalities, such as positron emission tomography and diffusion and perfusion magnetic resonance imaging. All of the most important tumor entities treated with radiation therapy are covered in the book. Each chapter is devoted to a particular tumor type and has been written by a recognized expert in that topic.

Contents:
Introduction and Overview.-Target Volume Delineation: Different Tumor Entities
Brain Gliomas and Brain Metastases
Base of the Skulls/Orbita
Spinal Column/ Spinal Cord
Head- and Neck-Tumors
Lung Tumors
Liver and Pancreas Tumors.-Gastrointestinal Tumor: Esophagus
Stomach
Colorectal Carcinoma
Anal Carcinoma
Sarcoma
Lymphomas
Prostate Cancer
Gynecological Cancer
Bladder
Mamma.

Summary: This practical guide, now in a revised and updated second edition with more clinical cases for different stages, is designed as a concise reference on the delineation of target volumes in radiation oncology. Clear guidance is provided on simulation, setup, and field design for all of the malignancies commonly encountered by practicing radiation oncologists, and slice-by-slice examples are provided for different clinical stages and scenarios. The new edition of this book fully covers modern radiotherapy field design, with inclusion of guidelines on immobilization and simulation for 3D-conformal radiotherapy, intensity-modulated radiation therapy, and stereotactic body radiation therapy. Target Volume Delineation and Field Setup: A Practical Guide for Conformal and Intensity-Modulated Radiation Therapy is written by leading radiation oncologists who provide their expert opinions on all relevant aspects.

Contents:
1.Nasopharyngeal Cancer
2.Oropharyngeal Cancer
3. Stereotactic Body Radiotherapy for Head and Neck Cancer
4. Larynx Cancer
5.Hypopharyngeal Cancer
6.Oral Cavity Cancer
7.Nasal cavity and Paranasal Sinus Cancer
8.Major Salivary Glands
9.Thyroid Cancer
10.Squamous Cell Carcinomas of Unknown Primary in the Head and Neck
11.Early Breast Cancer
12.Regional Lymph Node Irradiation for Breast Cancer
13.Lung Cancer
14.Esophageal Cancer
15.Gastric Cancer
16.Pancreatic Cancer
17.Hepatocellular Cancer
18.Rectal Cancer
19.Anal Cancer
20.Postoperative Therapy for Cervical, Vaginal, and Endometrial Cancer
21.Definitive Therapy for Cervical, Vaginal, and Endometrial Cancer
22.Image-guided brachytherapy Ovarian Cancer
23.Vulvar Cancer
24.Advanced Technologies and Treatment Techniques for Gynecologic Malignancies
25.Prostate Adenocarcinoma
26.Bladder Cancer
27.Testicular Seminoma
28.Brain Metastases
29.Benign Tumors of the CNS
30.Malignant tumors of the CNS
31.Hodgkin's and Non-hodgkin's Lymphoma
32.Soft Tissue Sarcoma
33.Pediatric Sarcoma
34.Pediatric Brain Tumors.

Summary: This textbook is designed to help the busy radiation oncologist to accurately and confidently delineate tumor volumes for conformal radiation therapy (including IMRT). The book provides an atlas of clinical target volumes (CTVs) for commonly encountered cancers, with each chapter illustrating CTV delineation on a slice-by-slice basis, on planning CT images. Common anatomic variants for each tumor are represented in individual illustrations, with annotations highlighting differences in coverage. The anatomy of each site and patterns of lymphatic drainage are discussed, and their influence on the design of CTVs is explained in detail. Utilization of other imaging modalities, including MRI, to delineate volumes is highlighted. Key details of simulation and planning are briefly reviewed. Although the emphasis is on target volume delineation for conformal techniques, information is also provided on conventional radiation field setup and design when IMRT is not suitable.

Contents:
Head and Neck Cancer: Nasopharynx
Oropharynx Cancer
Early Larynx
Advanced larynx
Hypopharyngeal Cancer
Oral Cavity Cancer
Paranasal Sinuses
Major Salivary gland
Thyroid Cancer
Cranial Nerves
Unknown Primary.- Head and Neck
Neck
Breast Cancer: Early Breast Cancer
Locally Advanced Breast
Thorax: Locally Advanced NSCLC &SCLD
SBRT and post-OP NSCLC
Gastrointestinal Cancer: Esophagus
Gastric
Pancreatic
HCC/Cholangiocarcinoma
Rectal Cancer
Anal Cancer
Gynecological Cancer: Cervical Cancer
Endometrial Cancer
Ovarian Cancer
Vaginal Cancer
Vulvar Cancer
Genitourinary Cancer: Prostate Cancer
Bladder Cancer.-Seminoma
CNS: Brain Metastasis
Benign
Low and High Grade Glioma
Lymphoma: Hodgkin's Disease
Non-Hodgkin's Disease
Musculoskeletal
Pediatrics: Sarcoma
Pediatric CNS.

Contents:
Intro; Preface; Contents;
1: Central Nervous System Normal Structures; 1.1 Introduction; 1.2 Visual System; 1.2.1 Lens; 1.2.2 Retina; 1.2.3 Optic Nerves, Chiasm, and Optic Tracts; 1.2.4 Visual Impairment; 1.3 Hypothalamus/Pituitary Gland; 1.4 Temporal Lobe; 1.4.1 Hippocampus; 1.5 Brainstem; 1.6 Temporal Bone: Cochleas; 1.6.1 Ototoxicity; References;
2: Noncentral Nervous System Normal Structures; 2.1 Introduction; 2.2 Head and Neck; 2.2.1 Head and Neck OAR (Fig. 2.1); 2.3 Chest; 2.3.1 Chest OAR (Fig. 2.2); 2.3.1.1 Lungs; 2.3.1.2 Heart Subsegments (Fig. 2.3) 2.3.1.3 Major Vessels2.3.1.4 Ribs and Chest Wall; 2.3.1.5 Brachial Plexus; 2.3.1.6 Spinal Cord; 2.3.1.7 Esophagus; 2.4 Abdomen; 2.4.1 Abdominal OAR (Fig. 2.4); 2.4.1.1 Liver; 2.4.1.2 Kidneys; 2.4.1.3 Bowel; 2.4.1.4 Pancreas; 2.4.1.5 Spleen; 2.5 Pelvis; 2.5.1 Pelvic OAR (Fig. 2.5); 2.6 Extremities; 2.6.1 Extremity OAR (Fig. 2.6); References;
3: Medulloblastoma; 3.1 Background; 3.1.1 Histology; 3.1.2 Staging; 3.1.3 Principles of Management; 3.2 Craniospinal Irradiation Contouring; 3.3 Focal Boosts to Resection Bed Plus Margins in Average-Risk Medulloblastoma 3.4 Whole Posterior Fossa Boosts in High-Risk Medulloblastoma3.5 Metastases; References;
4: Ependymoma; 4.1 Background and Epidemiology; 4.1.1 Pre-radiotherapy Imaging and Evaluation; 4.2 Management and Treatment of Intracranial Childhood Ependymoma; 4.2.1 Intracranial Ependymoma: Principles of Management; 4.2.2 Intracranial Ependymoma (Nondisseminated): General Considerations for Radiotherapy; 4.3 Management and Treatment of Childhood Spinal Ependymoma; 4.3.1 Spinal Cord Ependymoma: Principles of Management; 4.3.2 Spinal Cord Ependymoma: General Considerations for Radiotherapy 4.4 Special Considerations4.4.1 Disseminated Ependymoma; References; Suggested Reading;
5: Pediatric Intracranial Germinomas; 5.1 Introduction; 5.2 Diagnostic Workup, Stratification, and Staging; 5.3 Evolution of Radiation Fields; 5.4 Treatment Paradigm; 5.5 Simulation and Daily Localization; 5.6 Radiation Technique and Target Delineation (See Figs. 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, and 5.8); 5.7 Late Toxicity; References;
6: Craniopharyngioma; 6.1 Background; 6.1.1 Epidemiology; 6.1.2 Histologic Subtypes; 6.2 Presenting Findings and Anatomic Relationships; 6.3 Imaging 6.4 Surgery6.5 Radiotherapy; 6.5.1 Radiotherapy Techniques; 6.5.2 Planning and Simulation; 6.5.3 Image Fusion; 6.5.4 Normal Tissue Delineation; 6.5.5 Gross Tumor Volume Delineation; 6.5.6 Clinical Target Volume; 6.5.7 Planning Target Volume; 6.5.7.1 Imaging; 6.5.7.2 Operative Procedure; 6.5.7.3 Radiotherapy Planning; 6.5.7.4 Imaging; References;
7: Gliomas in Children; 7.1 Introduction; 7.2 Background; 7.3 Imaging; 7.4 General Principles; 7.5 Cases; 7.5.1 Juvenile Pilocytic Astrocytoma (JPA); 7.5.2 Low-Grade (Grade 2) Glioma; 7.5.3 High-Grade Glioma

Contents:
Part I: Overview. Overview of targeted quantitation of biomarkers and its applications / Naidong Weng
Translational application of biomarkers / Ray Bakhtiar
Current regulatory guidance pertaining biomarker assay establishment and industrial practice of fit-for-purpose and tiered approach / Naidong Weng
Modern liquid chromatography and mass spectrometry for targeted biomarker quantitation / Wenying Jian
Comparison between LC-MS and ligand-binding assay approaches for biomarker quantification / QingQing Wang, Lili Guo, and Ian A. Blair
Sample preparation methods for targeted biomarker quantification by LC-MS / Shichen Shen, Bo An, and Jun Qu
Overcome the endogenous levels in biomarker quantitation using LC-MS / Guowen Liu
Part II: Challenges and approaches. Sample collection for targeted biomarker quantitation by LC-MS / Yuzhong Deng and Xiaorong Liang
Nonspecific binding in LC-MS bioanalysis / Aimin Tan and John C. Fanaras
Strategies for improving sensitivity for targeted quantitation by LC-MS / Long Yuan and Qin C. Ji
Strategies to improve specificity for targeted biomarker quantitation by LC-MS / Yuan-Qing Xia and Jeffrey D. Miller
Biomarker quantitation using relative approaches / Shane M. Lamos and Katrina E. Wiesner
Part III: Applications. Targeted quantification of amino acid biomarkers using LC-MS / Barry R. Jones, Raymond F. Biondolillo, and John E. Buckholz
Targeted quantification of peptide biomarkers: a case study of amyloid peptides / Lieve Dillen, Marc De Meulder, and Tom Verhaeghe
Targeted protein biomarker quantitation by LC-MS / Yongle Pang, Chuan Shi, and Wenying Jian
Glycoprotein biomarkers / Shuwei Li, Stefani N. Thomas, and Shuang Yang
Targeted lipid biomarker quantitation using liquid chromatography-mass spectrometry (LC-MS) / Ashkan Salamatipour, Ian A. Blair, and Clementina Mesaros
Targeted LC-MS quantification of androgens and estrogens for biomarker development / Daniel Tamae
Steroid biomarkers / Mike (Qingtao) Huang, Shefali Patel, and Zhongping (John) Lin
Bile acids as biomarkers / Clara John, Philipp Werner, Joerg Heeren, and Markus Fischer
Biomarkers for vitamin status and deficiency: LC-MS based approach / Stanley (Weihua) Zhang and Jonathan Crowther
Quantitation of acyl-coenzyme A thioesters as metabolic biomarkers / Nathaniel Snyder
Neurotransmitter biomarkers / Guodong Zhang
Targeted quantification of carbohydrate biomarkers using LC-MS / Cong Wei and Hong Gao
Nucleoside/nucleotide biomarkers / Guodong Zhang
LC-MS of RNA biomarkers / Michael G. Bartlett, Babak Basiri, and Ning Li.

Summary: This book elaborates on various aspects of targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. Many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. An overview of pathways of intracellular uptake is presented with emphasis on RME pathways. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also clinical trials, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. This section also includes a chapter on cellular assays which was conceived to provide hands on training to young and nouveau researchers in the field of targeted nanomedicine.

Contents:
Part 1-Introduction and overview
Intracellular Delivery in Cancer and Infectious Diseases
Intracellular Delivery by Receptor Mediated Endocytosis
Part 2-Receptor and Receptor Medicated Endocytosis in Cancer
Receptors Relevant for Cancer Therapeutics
(chapters 3-8)
Part 3-Receptors and Receptor Medicated Endocytosis in Infectious Diseases
Receptors Relevant for Infectious Disease Therapeutics
(chapters 9-13)
Part 4-Common Receptors for Receptors and Receptor Mediated Endocytosis in Cancer and Infectious Diseases
Chapters 14-17)
Receptors Relevant for Cancer and Infectious Disease Therapeutics
Part 5-Models for Evaluation of Targeted Delivery in Cancer and infectious Diseases
In vitro and in vivo Models for Cancer and Infectious Diseases
In vitro and in vivo Models for Infectious Diseases
Part 6- Regulatory and Toxicity Issues
Regulatory and Toxicity Issues in Targeted Delivery.

Summary: Targeted intraoperative radiotherapy is a major advance in the management of cancer patients and has been attracting massive interest worldwide following publication of the results of an important randomized controlled trial in The Lancet. This textbook is designed to introduce this innovative technology in a comprehensive manner to clinicians dealing with cancer patients. Throughout, the emphasis is on practical aspects, and the text is supported by many excellent illustrations. The editors of the book have extensive experience in targeted intraoperative radiotherapy and include co-directors of the TARGIT Academy, which runs international training courses on the technology in the United Kingdom and Germany. They have brought together multidisciplinary contributors from different centers across the world who have wide experience in the field and whose work has been recognized internationally. It is the editors' hope that this book will succeed in ensuring that targeted intraoperative radiotherapy is used effectively worldwide.

Summary: "In this volume the authors promote, endorse and stimulate research in the vibrant field of biological inorganic chemistry. They provide an overview of metallodrugs which have been rationally designed to target specific biomolecules in the human body with a view to generating targeted drugs or prodrugs with widespread biomedical applications. The volume focuses on recent trends and advances in relation to targeted metallodrugs as anti-cancer, anti-microbial and anti-viral agents with an emphasis on their design, development and mode of action. It also include recent advances in the use of nanoparticles and nanoclusters as important chaperones to deliver metallodrugs to their sites of action"-- Provided by publisher.

Contents:
Metal-Based Prodrugs Activated by Cancer-Specific Stimuli
Light-Activated Drugs for Photodynamic and Photoactivated Therapy
Mitochondria as a Metallo-Drug Target for Therapeutic Purposes
Transition Metal-Based Anti-Viral Agents against SARS-CoV-2 and Other Pathogenic
Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs
Evaluating the Potential of Novel Metal-Based Drugs for Treating Drug Resistant Bacteria
Prospective Metallo-Drugs Including Bioactive Compounds: Selection of Co-Ligands to Tune Biological Activity against Neglected Tropical Diseases
Challenges in Targeting Cyanide Poisoning: Advantages in Exploiting Metal Complexes in Its Treatment
Advanced Microscopy Methods for Elucidating the Localization of Metal Complexes in Cancer Cells
Metalloproteomics: A Powerful Technique for Metals in Medicine
Metal-Based Nanoclusters for Biomedical Applications Radiometals in Molecular Imaging and Therapy.

Summary: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patients genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Contents:
1. EGFR
2. ALK
3. ROS1
4. B-RAF
5. MET
6. HER2
7. NTRK
8. SCLC
9. Complexities of the Lung Tumor Microenvironment
10. KRAS
11. Targeting Epigenetic Regulators in Cancer to Overcome Targeted Therapy Resistance.

Summary: This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Contents:
Introduction
Oncogene Addiction in Solid Tumors
Pharmacology and Clinical Development of New Molecularly Targeted Agents
Biomarkers as Prognostic, Predictive and Surrogate Endpoints
Evaluation of Response in Malignant Tumors Treated with Targeted Agents
Targeted Therapies for HER2-Positive Breast Cancer
Role of PARP Inhibitors in Triple Negative Breast Cancer (TNBC)
Targeted Therapies in Squamous Cell Carcinoma of the Head and Neck
Targeted Therapies for NSCLC
Targeted Therapies for Gastric Cancer
Targeted Therapies for Pancreatic Cancer
Targeted Therapies in Hepatocellular Carcinoma
Targeted Therapies for Colorectal Cancer
Targeted Therapy in Gastrointestinal Stromal Tumors
Targeted Therapies in Kidney Cancer
Targeted Therapies in Melanoma
Targeted Therapies for Prostate Cancer
Targeted Therapies for Bone Metastases.

Summary: This book aims to educate nurses and advanced practice providers (APP's) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP's are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP's with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Contents:
Chapter 1. Introduction
Chapter 2. Introduction to Mutation Testing
Chapter 3. Nursing Considerations with EGFR inhibitors in NSCLC
Chapter 4. Nursing Considerations with ALK and ROS1 inhibitors in NSCLC
Chapter 5. BRAF in Non-Small Cell Lung Cancer
Chapter 6. Mechanisms of acquired resistance to targeted therapy in NSCLC: Role of Repeat Biopsy and Nursing Considerations
Chapter 7. The Impact and Toxicity of Checkpoint Inhibitors in Management of Lung Cancer
Chapter 8. The Role of Anti-Angiogenic Agents (VEGF)
Chapter 9. Nursing Considerations for Patients Treated with Targeted Therapies.

Summary: This book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. The chapter topics include the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53, and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. In addition, chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells, and leukemia metabolism, provide insight into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies complete the overview of the multi-dimensional therapeutic landscape, where leukemia specialists develop treatment strategies, which are expected to bring forth critical breakthroughs in the field of leukemia.

Contents:
Preface Chapter 1- Colorectal Cancer Subtypes- the current portrait. 1 Peter Jordan Chapter 2- Targeting colon cancers with mutated BRAF and microsatellite instability. 17 Paulo Matos and Peter Jordan Chapter 3
Targeting KRAS mutant CMS3 subtype by metabolic inhibitors. 50 Oscar Aguilera and Roberto Serna-Blasco Chapter 4- Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer. 77 Maria Sofia Fernandes, João Miguel Sanches and Raquel Seruca Chapter 5- Targeting PTEN in colorectal cancers. 117 Larissa Kotelevets, Mark G.H. Scott and Eric Chastre Chapter 6- Wnt signalling-targeted therapy in the CMS2 tumour subtype: a new paradigm in CRC treatment? 162 Cristina Albuquerque and Lucília Pebre Pereira Chapter 7- Impact of the microenvironment on tumour budding in colorectal cancer. 216 Laurent MC Georges, Laurine Verset, Inti Zlobec, Pieter Demetter, Olivier De Wever Chapter 8- Anti-EGFR Therapy to treat metastatic colorectal cancer: not for all 241 Marta Martins, André Mansinho, Raquel Duarte, Soraia Lobo Martins and Luís Costa Chapter 9- miRNAs as modulators of EGFR therapy in colorectal cancer. 282 Diane M. Pereira and Cecília M. P. Rodrigues Index.

Contents:
Autophagy as a Therapeutic Target in Cancer.-Autophagy in Cancer Cells vs Cancer Tissues: two different stories
Small-Molecule Regulators of Autophagy as Potential Anti-Cancer Therapy
Regulation of autophagy by microRNAs: Implications in cancer therapy
Targeting PI3-kinases in modulating autophagy and anti-cancer therapy
Adult and Cancer Stem Cells:Perspectives on Autophagic Fate Determinations and Molecular Intervention
Role of autophagy in tumor progression and regression.

Summary: This book offers a much-needed discussion on the targeting of biofilm-related infections. Chapters include discussions on the impact of biofilm on medical implants, industrial applications, as well as wound and tissue infections. It also offers discussions on regulatory management for industrial sectors and medical environments. Given that there continues to be a paucity of effective antimicrobial products, devices, and coatings in clinical and industrial use that effectively reduce rates of infection or biofilm-related problems, Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors, offers a fresh and much-needed perspective aimed at helping create healthier controlled environments and safer devices. This comprehensive book is indispensable for industrial and academic translational researchers, device developers, and regulatory experts looking to create more effective antimicrobial products.

Summary: The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: Cancer Genes and Genomes; Cancer Pathways; Tumor Cell Biology; Cancer Growth & Progression; Innate & Adaptive Immune Responses; and Enabling Technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.

Contents:
Symposium participants
Foreword. Cancer stem cells : Normal and neoplastic stem cells / Melissa N. McCracken, Benson M. George, Kevin S. Kao, Kristopher D. Marjon, Tal Raveh, and Irving L. Weissman
Targeting the epithelial-to-mesenchymal transition: the case for differentiation-based therapy / Diwakar R. Pattabiraman and Robert A. Weinberg
Trimming the vascular tree in tumors: metabolic and immune adaptations / Elizabeth Allen, Rindert Missiaen, and Gabriele Bergers
Cell of origin and cancer stem cells in tumor suppressor mouse models of Glioblastoma / Sheila R. Alcantara Llaguno, Zuanhua Xie, and Luis F. Parada. Genetics and epigenetics : The enigma of p53 / Guillermina Lozano
Alterations in three-dimensional organization of the cancer genome and epigenome / Joanna Achinger-Kawecka, Phillippa C. Taberlay, and Susan J. Clark
COmposition and function of mammalian SWI/SNF chromatin remodeling complexes in human disease / John L. Pulice and Cigall Kadoch
The essential transcriptional function of BRD4 in acute myeloid leukemia / Jae-Seok Roe and Christopher R. Vakoc. Metabolism : Reexamining how cancel cells exploit the body's metabolic resources : Craig B. Thompson and Wilhelm Palm
Autophagy, metabolism, and cancer / Jessie Yanxiang Guo and Eileen White
A time for MYC: metabolism and therapy / Chi V. Dang
Beyond the oncogene revolution: four new ways to combat cancer / Thorsten Berger, Mary E. Saunders, and Tak W. Mak
Lipid synthesis is a metabolic liability of non-small cell lung cancer / Robert U. Svensson and Reuben J. Shaw. Targets, vaccines, and therapeutics : Cancer immunogenomics: computational neoantigen identification and vaccine design / Jasreet Hundal, Christopher A. Miller, Malachi Griffith, Obi L. Griffith, Jason Walker, Susanna Kiwala, Aaron Graubert, Joshua McMichauel, Adam Coffman, and Elaine R. Mardis
Targeting HIF2 in clear cell renal cell carcinoma / Hyejin Cho and William G. Kaelin
BET bromodomain proteins as cancer therapeutic targets / Shaokun Shu and Kornelia Polyak
To prime, or not to prime: that is the question / Danielle S. Potter and Anthony Letai
Genetic dissection of cancer development, therapy response, and resistance in mouse models of breast cancer / Stefano Annunziato, Marco Barazas, Sven Rottenberg, and Jos Jonkers. Microenvironment and metastasis : Tumor-stroma interactions in bone metastasis: molecular mechanisms and therapeutic implications / Hanqiu Zheng, Wenyang Li, and Yibin Kang
Cancer, oxidative stress, and metastasis / Jennifer G. Gill, Elena Piskounova, and Sean J. Morrison
RON signaling is a key mediator of tumor progression in many human cancers / Najme Faham and Alana L. Welm
Physical and chemical gradients in the tumor microenvironment regulate tumor cell invasion, migration, and metastasis / Madeleine J. Oudin and Valerie M. Weaver. Models of cancer : Pathways involved in formation of mammary organoid architecture have keys to understanding drug resistance and to discovery of druggable targets / Saori Furuta and Mina J. Bissell
Explaining the paucity of intratumoral T cells: a construction out of known entities / Douglas T. Fearon
Modeling breast cancer intertumor and intratumour heterogeneity using xenografts / Alejandra Bruna, Oscar M. Rueda, and Carlos Caldas
Challenges and opportunities in modeling pancreatic cancer / Michael E. Feigin and David A. Tuveson. Cancer genomics and tumor heterogeneity : Functional genomic characterization of cancer genomes / Thomas P. Howard, Francisca Vazquez, Aviad Tsherniak, Andrew L. Hong, Mik Rinne, Andrew J. Aguirre, Jesse S. Boehm, and William C. Hahn
How cancer genomics drives cancer biology: does synthetic lethality explain mutually exclusive oncogenic mutations? / Harold Varmus, Arun M. Unni, and William W. Lockwood
A pipeline for drug target identification and validation / Eusebio Manchado, Chun-Hao Huang, Nilgun Tasdemir, Darjus F. Tschaharganeh, John E. Wilkinson, and Scott W. Lowe
SIngle-cell analysis of circulating tumor cells as a window into tumor heterogeneity ? David T. Miyamoto, David T. Ting, Mehmet TOner, Shyamala Maheswaran, and Daniel A. Haber
Discovery of double-stranded genomic DNA in circulating exosomes / Raghu Kalluri and Valerie S. LeBleu. Summary : Moving closer to victory / Taru Muranen and Joan S. Brugge. Dorcas Cummings lecture : Charles Sawyers. Conversations at the symposium : Gabriele Bergers
Joan Brugge
Karen Cichowski
Susan Clark
Gerard Evan
Daniel Haber
William Kaelin
Raghu Kalluri
Scott Lowe
Guillermina (Gigi) Lozano
David Lyden
Elaine Mardis
Sean Morrison
Benjamin Neel
Luis Parada
Sir Michael Stratton
David Tuveson
Christopher Vakoc
Harold Varmus
Karen Vousden
Valerie Weaver
Robert Weinberg
Eileen White. Author index. Subject index.

Contents:
Targeting carbonic anhydrases / Clemente Capasso & Claudiu T. Supuran
Overview of carbonic anhydrase families/isoforms / Clemente Capasso & Claudiu T. Supuran
Classical sulfonamides and their bioisosters as carbonic anhydrase inhibitors / Jean-Yves Winum
Next-generation primary sulfonamide carbonic anhydrase inhibitors / Suleyman Akocak & Marc A. Ilies
Next-generation secondary/tertiary sulfonamide carbonic anhydrase inhibitors / Sébastien Thibaudeau, Hélène Carreyre, Agnès Mingot & Claudiu T. Supuran
Next-generation polyamine human carbonic anhydrase inhibitors / Fabrizio Carta & Andrea Scozzafava
Next-generation phenol carbonic anhydrase inhibitors / Pedro Alfonso Colinas
Coumarins that inhibit carbonic anhydrase / Sally-Ann Poulsen
Next-generation dithiocarbamate carbonic anhydrase inhibitors / Fabrizio Carta, Murat Bozdag, Muhammet Tanc & Claudiu T. Supuran
Protozoan, fungal and bacterial carbonic anhydrases targeting for obtaining anti-infectives / Clemente Capasso & Claudiu T. Supuran
Amine, amino acid and oligopeptide carbonic anhydrase activators / Giuseppina De Simone, Clemente Capasso & Claudiu T. Supuran
Targeting carbonic anhydrases in biotechnology / Clemente Capasso & Claudiu T. Supuran.

Contents:
Intro; Contents; Contributors; 1 An Introduction to the Book; Abstract; 2 Chitin: Structure, Chemistry and Biology; Abstract; 2.1 Introduction; 2.2 Chemistry; 2.3 Chemistry to Structure; 2.4 Structure to Biology; 2.5 Concluding Remarks; Acknowledgements; References; 3 Chitin Prevalence and Function in Bacteria, Fungi and Protists; Abstract; 3.1 Introduction; 3.2 Bacteria that Produce Chitin Oligosaccharides; 3.2.1 Nodulation Genes and Their Functions in Establishing Rhizobia-Legume Symbiosis; 3.3 Recognition of LCOs by Host Receptors 3.4 Fungi that Deposit Chitin (and Chitosan) as a Component of Cell (and Spore) Walls3.5 Cell and Spore Wall Structure in Fungi; 3.5.1 Structure and Regulation of the Chitin Synthase in Fungi; 3.5.2 Evolution and Classification of Fungal CHS Genes; 3.5.3 Chitin as a Target for the Immune System and Its Function in Pathogenicity and Symbiosis; 3.6 Chitin in Protists; 3.7 Methods Used for Chitin Detection in Protists; 3.8 Occurrence of Chitin in Protists; 3.9 Chitin in Pathogenic Protists; 3.10 Chitin Formation in Heterokont and Archaeplastidal Algae; 3.11 Conclusions; References 4.3.2.3 PRRs in Other Species4.3.3 Relevant Signal Transduction Pathways Involved in Chitin Perception; 4.3.3.1 Chitin-Induced Signal Transduction in Arabidopsis; AtPBL27; AtBIK1; 4.3.3.2 Chitin-Induced Signal Transduction in Rice; OsRLCK185; OsRac1; OsBSR1; 4.4 Concluding Remarks; References; 5 Chitin Organizing and Modifying Enzymes and Proteins Involved In Remodeling of the Insect Cuticle; Abstract; 5.1 Introduction; 5.2 Chitin Synthases, the Enzymes that Polymerize Precursors of Chitin; 5.2.1 A Mechanistic View on Chitin Synthesis, Translocation and Fibrillogenesis 5.2.2 Specialization Among CHS Isoforms5.3 Chitinases; 5.3.1 Group I Chitinases; 5.3.2 Group II Chitinases; 5.3.3 Group III Chitinases; 5.3.4 TEM Analyses of Cuticle; 5.3.5 Group IV Chitinases; 5.3.6 Group V Chitinases; 5.3.7 Group VI Chitinases; 5.3.8 Other Chitinase Families; 5.4 N-acetylglucosaminidases; 5.5 Molting Fluid-Associated Chitinolytic Enzymes; 5.6 Chitin Deacetylases (CDAs); 5.6.1 Arthropod/Insect CDAs; 5.7 Chitin-Remodeling Proteins; 5.7.1 Knickkopf Family of Proteins; 5.7.2 CPAP Proteins; 5.7.3 Peritrophic Matrix Proteins (PMPs); 5.7.4 CPR Family Proteins

Summary: The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected.

Contents:
Structural Biology of Notch Signaling
Non-Canonical Notch Signaling
Dual Function of Notch Signaling in Cancer
Oncogene and Tumorsuppressor
Out on the Fringe: Modulation of Notch Signaling by Glycosylation
Notch signaling: A pivot regulator of adaptive and innate immunity
Notch in Ovarian Cancer
Notch Signaling in Graft-versus-Host Disease
Notch Signaling in T-Cell Acute Lymphoblastic Leukemia and Other Hematologic Malignancies
The Role of Notch in Breast Cancer
Notch in Lung Cancer
Notch Signaling in Pediatric Soft tissue Sarcoma
Notch Ligands in Hematopoietic Stem Cell production
Notch Signaling in the normal intestine and intestinal Cancer
Notch Signaling in Estrogen-Dependent Cancers
Index.

Contents:
Epidemiology and Management: Epidemiology
Emerging Role of HPV
Management of Oral Cancer. Development and Biomarkers: Molecular Progression and Signaling
Stem Cells and Tumor Development
Prognostic/Predictive Biomarkers
EIF4e as Biomarker and Target. Breaking Developments and New Drug Discovery: Current Clinical Trials
Emerging Drug Targets
Targeting the UPR
Targeting Meditators of Coagulation
Resveratrol Pre-Sensitizing
Academic High Throughput Drug Discovery.

Summary: This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17-Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals.

Contents:
Introduction
Overview of IL-17 family.-Il-17 in host defense
Th17 cells: differentiation and regulation
The role of the IL-17/Th17 pathway in the pathogenesis of autoimmune inflammatory diseases
Therapeutic applications: strategies and molecules targeting the IL-17/Th17 pathway
Concluding remarks.

Contents:
Preface
The tattooed and the social environment. The cultural heritage of tattooing: a brief history
Epidemiology of tattoos in industrialized countries
The practise of tattooing. Tattoo machines, needles and utilities
The technique and craftsmanship of tattooing in the professional tattoo parlour
Tattoo as art, the drivers behind the fascination and the decision to become tattooed
Personal records from my tattoo parlour: deep emotions drawn as life-long pictures on the skin's canvas
Tattooist-customer relationships in a diversified environment of professional tattooists and 'scratchers'
Tattoos and adverse events. Tattoo complaints and complications: diagnosis and clinical spectrum
Complications of cosmetic tattoos
Chronic tattoo reactions cause reduced quality of life equaling cumbersome skin diseases
Contraindications for tattooing
Laser tattoo removal, precautions, and unwanted effects
Nano-scale observations of tattoo pigments in skin by atomic force microscopy
Manufacturing, materials and properties of marketed tattoo ink stock products. Manufacturing of tattoo ink products today and in future
The realistic variables underlying true safety in tattoo pigment manufacturing
Making innovative tattoo ink products with improved safety: possible and impossible ingredients in practical usage
Tailored surface engineering of pigments by layer-by-layer coating
Ingredients, chemical analysis and safety of marketed tattoo ink stock products. Chemical purity and toxicology of pigments used in tattoo inks
Survey on european studies of the chemical characterisation of tattoo ink products and the measurement of potentially harmful ingredients
Tattoo inks: legislation, pigments, metals and chemical analysis
The challenges and limitations of chemical analysis of particulate pigments of very low solubility
Photostability and breakdown products of pigments currently used in tattoo inks
Carbon black nanoparticles and other problematic constituents of black ink and their potential to harm tattooed humans
Absorption, distribution, metabolism and excretion of tattoo colorants and ingredients in mouse and man: the known and the unknown
Towards the limiting of health risks associated with tattooing: whitelists for tattoo pigments and preservatives
Survey of studies on microbial contamination of marketed tattoo inks
Regulation of and intervention in the tattoo business. The European landscape of national regulations of tattoo inks and businesses
Implementation of European Council Resolution ResAP(2008)1 in Italy. National and regional regulation of tattoo practices: diversity and challenges
EU actions to ensure the safety of tattoos and the protection of consumers
Surveillance of tattoo-related adverse events by the EU RAPEX System and by national monitoring
The Amsterdam model for control of tattoo parlours and businesses
Hygiene standards for tattooists
Hygiene standards in the tattoo parlour and practices for prevention of infection
Seamless prevention of adverse events from tattooing: integrated strategy emphasising the customer-tattooist interaction
Regulation of tattoo ink production and the tattoo business.

Summary: This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Contents:
1) Structure and role of Tau molecule
(1) Tau structure in solution: FRET study
(2) Tau structure in solution: NMR study
(3) Structure of NFT: Biochemical approach
(4) Structure of NFT: CryoEM approach
(5) MAPT tau gene and FTDP-17 mutation
(6) Tau phosphorylation
(7) Tau acetylation
(8) Tau truncation
(9) Tau interacted proteins: interactome
(10) Tau clearance mechanism
2) Tau localization and function
(11) Localization of Tau
(12) Axonal transport
(13) Synaptic localization of tau
(14) Role of tau in synapse
(15) Tau in nucleus and nucleic acids
(16) Tau and the translational stress response
3) Tauopathies; pathology, drivers, and marker
(17) Tau pathology with aging
(18) Clinical symptom and pathology of FTD including FTDP-17
(19) Chronic Traumatic Encephalopathy
(20) Myotonic dystrophies
(21) Tau PET
(22) Tau PET/connectome/fMRI
(23) Stress
(24) Diabetes
(25) Relationship between ApoE and tau
(26) Relationship between Ab and tau
4) Tau aggregation, and therapy
(27) Tau Oligomer
(28) Tau droplet formation
(29) Stress granule
(30) Tau secretion
(31) Tau seeding
(32) Prion-like Tau propagation
(33) Experimental models for tauopathies
(34) Dementia therapy targeting tau
(35) Tau aggregation inhibitor.

Summary: Taurine 9 contains original articles and critical reviews based on the oral and poster presentations of XIX International Taurine Meeting held in Kraków, Poland in May 2014. The purpose of the book is to present current ideas, new avenues and research regarding biological functions and clinical applications of taurine and taurine derivatives. It focuses on all aspects of taurine research including the cardiovascular system, the immune system, diabetes, the central nervous system, endocrine system and the role of taurine supplements in nutrition. It also includes presentations of novel animal experimental models using Cdo1 and CSAD knock-out mice.

Summary: This book provides comprehensive, authoritative descriptions of the microbes involved in cleaning up oil spills and degrading climate-altering hydrocarbons such as methane, and has detailed discussions about the taxonomy, ecology, genomics, physiology and global significance of these hydrocarbon-degrading microbes.

Contents:
Prokaryotic Hydrocarbon Degraders
Aerobic Hydrocarbon-Degrading Archaea
Eukaryotic Hydrocarbon Degraders
Aerobic Hydrocarbon-degrading Bacteroidetes
Aerobic Hydrocarbon-Degrading Alphaproteobacteria: Rhodobacteraceae (Roseobacter)
Aerobic Hydrocarbon-Degrading Alphaproteobacteria: Sphingomonadales
Hydrocarbon Degradation by Betaproteobacteria
Marine, Aerobic Hydrocarbon-Degrading Gammaproteobacteria: Overview
Aerobic Hydrocarbon-degrading Gammaproteobacteria
Oleiphilaceae
Marine, Aerobic Hydrocarbon-Degrading Gammaproteobacteria: The Family Alcanivoracaceae
Aerobic Hydrocarbon-Degrading Gammaproteobacteria: Porticoccus
Aerobic Hydrocarbon-Degrading Gammaproteobacteria: Xanthomonadales
Anaerobic Hydrocarbon-Degrading Deltaproteobacteria
The Methane-Oxidizing Bacteria (Methanotrophs)
Facultative Methane Oxidizers
Hormoconis resinae, The Kerosene Fungus
Global Consequences of Ubiquitous Hydrocarbon Utilizers
Occurrence and Roles of the Obligate Hydrocarbonoclastic Bacteria in the Ocean When There Is No Obvious Hydrocarbon Contamination
Hydrocarbon-Degrading Microbes as Sources of New Biocatalysts.-.

Contents:
A history of pediatric ophthalmology and strabismus
Epidemiology and the worldwide impact of visual impairment in children
Clinical embryology and development of the eye
Developmental biology of the eye
Clinical aspects of normal and abnormal visual development and delayed visual maturation
Milestones and normative data
Examination, history and special tests in pediatric ophthalmology
Managing refractive errors in children
Visual electrophysiology : how it can help you and your patient
Imaging the child's eye, orbit, and visual pathways
Genetics and pediatric ophthalmology
Congenital infections of the eye
Conjunctivitis of the newborn
Preseptal and orbital cellulitis
Endophthalmitis
External eye disease and the oculocutaneous disorders
Ocular manifestations of hiv/aids in children
Disorders of the eye as a whole
Lids : congenital and acquired abnormalities ? practical management
Lid and orbital infantile periocular hemangiomas (capillary hemangiomas) and other vascular diseases
Lacrimal system
The management of orbital disease in children
Neurogenic tumors
Orbital rhabdomyosarcoma
Other mesenchymal abnormalities
Metastatic, secondary and lacrimal gland tumors
Histiocytic, hematopoietic, and lymphoproliferative disorders
Craniofacial abnormalities
Cystic lesions and ectopias
Inflammatory disorders
Conjunctiva and subconjunctival tissue
Conjunctival tumors
Anterior segment developmental anomalies including aniridia
Corneal abnormalities in childhood
Corneal dystrophies
The lens
Childhood cataracts
Childhood glaucoma
Pediatric iris disorders
Uveitis
Albinism
Vitreous
Retinoblastoma
Retinopathy of prematurity
Current treatment of retinopathy of prematurity
Inherited retinal disorders
Retinal dystrophies with systemic associations and the retinal ciliopathies
Inherited macular dystrophies
Congenital pigmentary and vascular abnormalities of the retina
Retinal flecks, dots and crystals
Acquired and other retinal diseases (including juvenile x-linked retinoschisis)
Retinal detachment in childhood
Congenital anomalies of the optic discs
Hereditary optic neuropathies
Other acquired optic disc abnormalities in children
Demyelinating, inflammatory, infectious, and infiltrative optic neuropathies
The optic chiasm
Headache in children
Raised intracranial pressure
The brain and cerebral visual impairment
Delivering bad news
Common issues arising in children with visual impairment
Visual conversion disorders : fabricated or exaggerated symptoms in children
Dyslexia
Neurometabolic disease and the eye
Pupil anomalies and reactions
Leukemia
Phakomatoses (including the neurofibromatoses)
Accidental trauma in children
Child maltreatment, abusive head trauma, and the eye
Refractive surgery in children
Binocular vision
Amblyopia : basics, questions, and practical management
Anatomy of strabismus
The orthoptic evaluation
Infantile esotropias
Accommodative esotropias
Special esotropias (acute comitant, sensory deprivation, myopia-associated and microtropia)
Intermittent exotropia
Special forms of comitant exotropia
Vertical strabismus
"a," "v," and other pattern strabismus
Congenital cranial dysinnervation disorders
Ocular motor nerve palsies
Strabismus : nonsurgical treatment
Strabismus surgery
Minimally invasive strabismus surgery
Strabismus surgery complications and how to avoid them
Nystagmus in childhood
Supranuclear eye movement disorders, acquired and neurologic nystagmus
"I think my baby can't see!"
"My baby's got a red eye, doctor!"
"My child keeps blinking and closing his eye"
"M child seems to hate the bright light"
"M child's eyes keep watering!"
Proptosis at different ages
"M child's teacher says she can't see properly!"
"M child could see perfectly but now the vision is weak!"
The child with a dual sensory loss (deafblind)
"M little girl tells me she sees strange things"
Wobbly eyes in infancy
Abnormal head postures in children
Hand defects and the eye
Optimizing compliance in patching therapy
Vision screening
Self-inflicted ocular injuries
Apps and all that ? (how my smartphone changed my life).

Contents:
Skin of color : a historical perspective
Defining skin of color
Epidemiology of cutaneous diseases
Multicultural competence in dermatologic practice
The impact of traditional cultures on health care practices : an overview
The impact of traditional African American cultures on heath care practices
The impact of traditional Asian cultures on health care practices
The impact of traditional Hispanic cultures on health care practices
The impact of traditional Arabian Gulf cultures on health care practices
Psychiatric aspects of skin of color
The structure and function of skin of color
Histology
Genetics of skin diseases
Biology of hair follicles
Biology of nails
Biology of the oral mucosa
Biology of wounds and wound care
Acute effects of light on the skin
Chronic effects of light on the skin
Nuances of skin of color
Skin lesions : normal and pathologic
Dermatosis papulosa nigra
Seborrheic dermatitis
Psoriasis
Pityriasis rosea
Lichen planus and lichen nitidus
Atopic dermatitis and other eczemas
Allergic contact dermatitis
Photosensitivity
Erythema chronicum perstans and related disorders
Amyloidosis
Acquired bullous diseases.

Summary: "Taylor's Differential Diagnosis manual is a quick-reference pocket book, written for primary care professionals who face diagnostic problems in brief office visits. It offers evidence-based guidelines on which key questions to ask and what data to obtain in order to provide sound diagnoses of common adult problems. More than 140 chapters in eighteen sections cover symptoms and signs in mental health problems, vision, ear nose and throat, cardiovascular, respiratory, urologic, female reproductive, musculoskeletal, dermatology and more. New for this edition are new chapters on abnormal mammogram, anticoagulation, bipolar disorder, corneal abrasion, dyspareunia and loss of vision as well as the latest clinical evidence and changes in clinical practice since the prior edition"--Provided by publisher.

Contents:
How to use this text to pass
Test taking strategies
Special considerations
Clinical practice : head and neck
Clinical practice : trunk
Clinical practice : extremity and wound
Continuum of care for trauma
Professional issues
Environmental & pharmacology
Special populations : pediatric, geriatric, bariatric
Special populations : obstetrical, newborn.

Summary: This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book's final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.

Contents:
1 Introduction: How we encountered TCTP and our purpose in studying it
2 Structural insights into TCTP and its interactions with ligands and proteins
3 Structure-Function relationship of TCTP
4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation
5 Current understanding of the TCTP interactome
6 Role and fate of TCTP in protein degradative pathways
7 Roles of the Translationally Controlled Tumor Protein (TCTP) in plant development
8 Function of Translationally controlled tumor protein in organ growth: Lessons from Drosophila studies
9 Translationally controlled tumor protein (TCTP/HRF) present in animal venoms
10 Tctp in Neuronal Circuitry Assembly
11 Elusive role of TCTP protein and mRNA in cell cycle and cytoskeleton regulation
12 TCTP protein and the cellular response to ionizing radiation-induced DNA damage
13 TCTP has a crucial role in the different stages of Prostate Cancer malignant progression
14 Role of TCTP for cellular differentiation and cancer therapy
15 Targeting TCTP with sertraline and thioridazine in cancer treatment
16 . History of Histamine Releasing Factor (HRF)/TCTP including a Potential Therapeutic Target in Asthma and Allergy.

Summary: "With expert guidance on all aspects of gynecologic surgery, Te Linde's Operative Gynecology, Thirteenth Edition, edited by Drs. Linda Van Le and Victoria L. Handa, remains your go-to resource from preoperative to postoperative care. Comprehensive, step-by-step instructions on how to perform all contemporary gynecologic procedures, updated diagnostic and management approaches, a greatly expanded illustration program, and new procedural videos, edited by Dr. Danielle Patterson, make this classic text an ideal reference for trainees as well as experienced practitioners." Provided by publisher

Contents:
Section I: Preparing for surgery
Section II: Basic principles of gynecologic surgery
Section III: Postoperative care
Section IV: Contemporary gynecologic surgical procedures
Section V: Gynecologic oncology
Section VI: Surgery for pelvic floor disorders
Section VII: Complications of pelvic surgery
Section VIII: Surgical management of selected gynecologic conditions.

Contents:
Operative gynecology before the era of laparoscopy: a brief history
The ethics of pelvic surgery
Psychological aspects of pelvic surgery
Risk prevention, risk management, and professional liability
The changing environment in which we practice gynecologic surgery
Training the gynecologic surgeon: maintaining and improving surgical skills
Surgical anatomy of the female pelvis
Preoperative care of the gynecologic patient
Postanesthesia and postoperative care
Water, electrolyte, and acid-base metabolism
Postoperative infections: prevention and management
Shock in the gynecologic patient
Wound healing suture material, and surgical instrumentation
Incisions for gynecologic surgery
Principles of electrosurgery and laser energy applied to gynecologic surgery
Diagnostic and operative laparoscopy
Robotic surgery
Operative hysteroscopy
Control of pelvic hemorrhage
The impact of assisted reproductive technology on gynecologic surgery
Reconstructive tubal surgery
Endometriosis
Surgical conditions of the vulva
Surgical conditions of the vagina and urethra
Surgery for anomalies of the müllerian ducts
Normal and abnormal uterine bleeding
Tubal sterilization
Surgery of benign disease of the ovary
Persistent or chronic pelvic pain
Pelvic inflammatory disease
Leiomyomata uteri and myomectomy
Abdominal hysterectomy
Vaginal hysterectomy
Laparoscopic hysterectomy
Management of abortion
Ectopic pregnancy
Surgical management of obstetric complications
Ovarian tumors complicating pregnancy
Pelvic organ prolapse: basic principles
Reconstruction of the anterior vagina for prolapse
Posterior compartment defects
Vaginal vault prolapse
Nonsurgical management of pelvic organ prolapse: the use of vaginal pessaries and pelvic floor muscle training
Stress urinary incontinence
Operative injuries to the ureter
Vesicovaginal and urethrovaginal fistulas
Anal incontinence and rectovaginal fistula
Diseases of the breast
The verminform appendix in relation to gynecology
Intestinal surgery for the gynecologic surgeon
Nongynecologic conditions encountered by the gynecologic surgeon
Malignancies of the vulva
Cervical cancer precursors and their management
Cancer of the cervix
Endometerial cancer
Ovarian cancer
Pelvic extenteration
Surgical reconstruction of the pelvis in gynecologic cancer patients.

Contents:
Section I Preparing for Surgery: Surgical anatomy of the female pelvis
Preoperative care of the gynecologic patient
Section II Principles of Gynecologic Surgery: Anesthesia primer for the gynecologist
Patient positioning for pelvic surgery
Surgical techniques, instruments, and suture
Incisions for gynecologic surgery
Surgical control of pelvic hemorrhage
Principles of laparoscopy
Principles of robotic surgery
Section III Perioperative and Postoperative Care of the Gynecologic Patient: Postoperative care of the gynecologic patient
Section IV Contemporary Gynecologic Surgical Procedures
Dilation and curettage
Hysteroscopy
Surgical management of abortion and its complications
Surgery for benign vulvar conditions
Tubal sterilization
Surgery of the ovary and fallopian tube
Myomectomy
Vaginal hysterectomy
Abdominal hysterectomy
Laparoscopic and robotic-assisted hysterectomy
Section V: Gynecologic Oncology
Section VI: Surgery for Pelvic Floor Disorders
Section VII: Management of Selected Gynecologic Conditions
Section VIII: Surgery for Obstetrical Complications.

Summary: Teaching Anatomy: A Practical Guide is the first book designed to provide highly practical advice to both novice and experienced gross anatomy teachers. The volume provides a theoretical foundation of adult learning and basic anatomy education and includes chapters focusing on specific issues that teachers commonly encounter in the diverse and challenging scenarios in which they teach. The book is designed to allow teachers to adopt a student-centered approach and to be able to give their students an effective and efficient overall learning experience. Teachers of gross anatomy and other basic sciences in undergraduate healthcare programs will find in this unique volume invaluable information presented in a problem-oriented, succinct, and user-friendly format. Developed by renowned, expert authors, the chapters are written concisely and in simple language, and a wealth of text boxes are provided to bring out key points, to stimulate reflection on the reader?s own situation, and to provide additional practical tips. Educational theories are selectively included to explain the theoretical foundation underlying practical suggestions, so that teachers can appropriately modify the strategies described in the book to fit their own educational environments. Comprehensive and a significant contribution to the literature, Teaching Anatomy: A Practical Guide is an indispensable resource for all instructors in gross anatomy.

Contents:
1. Elements Of Successful Adult Learning.- 2. Characteristics Of Students Of The Millennial Generation.- 3. Students Learning Styles In Anatomy.- 4. Outcome-Based Approach To Student Learning
5. Competencies Needed For Teaching Anatomy Effectively And Efficiently.- 6. Using Teaching Assistants In Anatomy.- 7. Engaging Residents And Clinical Faculty In Anatomy Education.- 8. Giving A Lecture.- 9. Engaging Students In Active Learning In The Large Group Setting
10. Preparing and Recording Lectures For On-Line Delivery
11. Evaluating Your Own Performance In A Lecture.- 12. Choosing Between Lecture and Briefing Session.- 13. Facilitating Small Group Discussion
14. Engaging Students With Different Learning Styles And Behavioral Problems
15. Promoting The Learning Of Anatomy In PBL Environment
16. Promoting The Learning Of Anatomy In CBL Environment.- 17. Promoting The Learning Of Anatomy In TBL Environment.- 18. Giving Feedback To Students
19. Using Body Painting To Teach Anatomy.- 20. Evaluating Your Own Performance In Leading A Small Group Discussion.- 21. Running A Body Donation Program.- 22. Designing Gross Anatomy Laboratory To Meet The Needs Of Today?s Learner.- 23. Preparing Students Emotionally For The Human Dissection Experience
24. Promoting Reflection In The Laboratory.- 25. The Pros And Cons Of Dissection And Prosection.- 26. Use Of Fresh Specimens In Anatomy Teaching And Learning.- 27. Instruments For Facilitating Anatomy Learning In The Laboratory.- 28. The Use Of Digital Human Models.- 29. Essential E-Learning and M-Learning Methods for Teaching Anatomy.- 30. The Use Of Low-Tech Models To Enhance The Learning Of Anatomy.- 31. The Use Of The Gross Anatomy Museum For Teaching And Learning.- 32. Different Methods For Assessing Anatomical Knowledge.- 33. Writing Good Questions In Anatomy.- 34. Assessing Non-Discipline Related Skills And Competencies.- 35. The Anatomy Components In Different Types Of Curricula.- 36. The Role Of An Anatomist In A Healthcare Curriculum.- 37. Identity Of Anatomy Teacher In An Integrated Curriculum.- 38. Hidden Curriculum In Anatomy
39. Dental Program.- 40. Allied Health Program.- 41. Research Methods In Anatomy Education.- 42. Educational Research Opportunities In Anatomy.

Summary: This book considers the evolution of medical education over the centuries, presents various theories and principles of learning, and discusses different forms of medical curriculum and the strategies employed to develop them, citing examples from medical schools in developed and developing nations. Instructional methodologies and tools for assessment and evaluation are discussed at length and additional elements of modern medical teaching, such as writing skills, communication skills, evidence based medicine, medical ethics, skill labs, and webinars, are fully considered. In discussing these topics, the authors draw upon the personal experience that they have gained in learning, teaching and disseminating knowledge in many parts of the world over the past four decades. .

Contents:
Introduction
Evolution of medical education over millennia
Medical education in twentieth century
Theories and principles of learning :Pedagogy and Andragogy
The triangle of medical education
Curriculum development
Instructional strategies
Assessment and evaluation
Research methodology
Medical writing
Evidence Based Medicine
Communication skills
Medical ethics, etc
Case study and a model of COME ( Community Oriented Medical Education)
Some other models eg. MLEs and curricula in the Caribbean medical schools
Medical education at American University of Barbados
Some other models to view
Epilogue.

Contents:
Clinical reasoning and diagnostic error / Robert L. Trowbridge Jr., Mark L. Graber
Theoretical concepts to consider in providing clinical reasoning instruction / Temple A. Ratcliffe, Steven J. Durning
Developing a curriculum in clinical reasoning / Joseph J. Rencic, Robert L. Trowbridge Jr., Steven J. Durning
Educational approaches to common cognitive errors / James B. Reilly
General teaching techniques / Cynthia H. Ledford, L. James Nixon
Assessment of clinical reasoning / Valerie J. Lang, Lambert Schuwirth, Joseph J. Rencic, Steven J. Durning
Faculty development and dissemination / Jennifer R. Kogan, Eric Holmboe
Lifelong learning in clinical reasoning / Gurpreet Dhaliwal
Remediation of clinical reasoning / Michael Elnicki, Joan M. von Feldt
Novel approaches and future directions / Jeffrey S. La Rochelle, Anthony R. Artino, Dario M. Torre
Afterword : teaching clinical reasoning : where do we go from here? / Steven J. Durning, Joseph J. Rencic, Lambert Schuwirth, Robert L. Trowbridge Jr.

Summary: Practicing evidence-based medicine is widely regarded both as best clinical practice, and as the cornerstone of meeting the ACGME competencies in Practice-Based Learning and Improvement. Training programs recognize the need to teach the skills of EBM and yet struggle with readily available content and guidance on putting together a curriculum. Time frames for delivering curricula in residency can be very tight, often restricted to scattered one hour conferences. This book provides a modular curriculum structure for instructors, with each topic area taking up one section, or one hour of instructional time. Developed over the past 14 years as an introductory course for interns in the internal medicine residency program at Duke, the curriculum will cover core content areas in evidence-based medicine and best teaching practices for them and skills such as literature searching and applying evidence to patients. Most importantly, it will center on actual patient questions and use current literature as examples that instructors can use as teaching exercises. There will also be ample diagrams that have been shown to be effective with learners and each module will include a video tutorial of a sample teaching session, including visual aids and small group teaching techniques. The curriculum can be implemented in any time frame necessary, compressed or longitudinal, to a variety of learners. This is an ideal guide for residency program directors and core faculty, either within internal medicine or more broadly in family medicine, pediatrics, surgery, OB-gyn, as well as medical school faculty for use with students.

Contents:
1. How To Use This Book
2. Clinical Question and Study Design
3. Searching the Medical Literature
4. Therapy: Assessing the Value of Clinical Interventions
5. Non-inferiority Study Designs
6. Harm and Causation: Assessing the Value of Studies of Harm
7. Diagnostic Testing: Assessing the Value of Studies of Diagnostic Tests
8. Screening
9. Prognosis
10. Systematic Reviews and Meta-Analysis
11. Shared Decision Making.

Contents:
Teaching medicine
Meet the attending
Building the team
A safe, supportive environment
Bedside and beyond
How to think about thinking
Role models
The sacred act of healing
Putting it all together.

Summary: This book uses real-world clinical case analyses of hot topics to provide insights into noninvasive mechanical ventilation (NIV). Written by leading international teachers and experts, it features a selection of "major controversial topics in clinical practice" and demonstrates how these cases can be used to teach about NIV. It then presents a discussion of the topics in various scenarios (anesthesiology, critical care, emergency and pneumology). The chapters allow readers to develop a case-by-case understanding of NIV in acute and chronic respiratory disorders, and perioperative and in intensive care patients, also thanks to Electronic Supplementary Materials. Lastly the authors summarize five key points / recommendations. This book is an attractive resource also for universities/ educational seminars/ national and international postgraduate courses and hot-topics sessions at national/international congresses.

Contents:
Part I. CLINICAL CASES IN NONINVASIVE VENTILATION INTERFACES, METHODOLOGY
1. Facemask and total face mask
2. HELMET
3. Mouthpiece Ventilation
4. DISCOMFORT AND ADAPTATION IN NON INVASIVE MECHANICAL VENTILATION: MASK INTERFACE PROBLEMS
5. Discomfort and adaptation. Mask interface problems
6. Unusual Facial Muscle Atrophy associated with Noninvasive ventilation
7. Noninvasive Ventilation: Continuous Positive Air Pressure Ventilation (CPAP) and Pressure Support Ventilation (PSV)
8. Continuous Positive Airway Pressure (CPAP)
9. How Do Hybrid Pressure Ventilation Modes Respond to Patients Varying Ventilatory Requirements? Insights from Respiratory Bench Simulations
Part II. CLINICAL CASES AND NON INVASIVE VENTILATION PHYSIOLOGY
10. Noninvasive ventilation Extrapulmonary response determinants
11. Noninvasive ventilation .Patterns response (apnea, hypopnea, tachypnea)
12. LUNG MECHANICS- COMPLIANCE AND RESISTANCE-EXTRAPULMONARY RESPONSE
Part III. CLINICAL CASES AND NON INVASIVE VENTILATION PATTERN RESPONSE
13. Early and Late Failure during Noninvasive Ventilation
14. Noninvasive ventilation. Rebreathing
15. Bilateral Pneumothorax in neuromuscular disease associated with noninvasive ventilation and mechanical insufflation-exsufflation
16. Early and Late Failure During Noninvasive Ventilation
Part IV. NON INVASIVE VENTILATION INTERACTION, MONITORING AND METHODOLOGY
17. Patient ventilator asynchrony
18. Non invasive ventilation in Patient Ventilator Asynchrony
19. Clinical cases in Non Invasive Ventilation - Pressure waveform
20. Pressure waveform. Clinical interpretation -Acute Respiratory failure in COPD
21. Intensive Care Unit Ventiltors some aspects in noninvasive mechanical ventilation
Part V. CLINICAL CASES IN NONINVASIVE VENTILATION - NIV IN PROCEDURES APPLICATIONS
22. Non invasive mechanical ventilation and echocardiografic procedure
23. lung and diaphragm ultrasound for monitoring patients ongoing non-invasive mechanical ventilation
24. Non invasive mechanical ventilation and Bronchoscopy
25. Clinical cases in Noninvasive Ventilation - NIV in procedures applications. Bronchoscopy
Part VI. CLINICAL CONDITIONS -ACUTE HYPOXEMIC RESPIRATORY FAILURE
26. Noninvasive Ventilation in Hematology- Oncology Patients with acute respiratory failure
27. Treatment of acute respiratory failure in patient with congestive heart failure and pneumonia
28. Neurally adjusted ventilator (NAVA) mode
29. Non-invasive mechanical ventilation in pneumonia
30. Non invasive ventilation in High risk infections
31. Clinical conditions -acute hypoxemic respiratory failure: Non invasive ventilation in Pneumonia
32. Non invasive ventilation in asthma exacerbation
33. UNUSUAL CASE OF ACUTE PULMONARY EDEMA TREATED BY NON INVASIVE VENTIATION a 30 years ago "cold case"!
34. Non-invasive mechanical ventilation in acute cardiac pulmonary edema
35. Clinical Conditions Acute Hypoxemic respiratory failure - Non invasive ventilation in Thoracic Trauma
36. Thoracic Surgery, a clinical case in non-invasive Ventilation -Clinical conditions in the perioperative period
37. Non-Invasive Ventilation following Thoracotomy. Clinical Case
38. Noninvasive Ventilation in Acute Respiratory Distress Syndrome
39. Nasal high flow oxygen During Post-Extubation Period in a Patient with Traumatic Brain Injury
Part VII. CLINICAL CONDITIONS SLEEP BREATHING DISORDERS
40. Treatment-Emergent Central Sleep Apnea: Always Look for an Air Leak
41. Non invasive ventilation in Sleep apnea syndrome
42. Nocturnal Hypoventilation and Sleep Breathing Disorders
43. Non invasive ventilation, nocturnal hypoventilation and sleep breathing disorders
Part VIII. CLINICAL CONDITIONS CHRONIC HYPERCAPNIC RESPIRATORY FAILURE
44. Noninvasive ventilation in Chronic obstructive pulmonary disease ventilating the patient with severe respiratory acidosis
45. Noninvasive ventilation in Chronic obstructive pulmonary disease
46. Non-invasive ventilation in adults with cystic fibrosis
47. Non invasive mechanical ventilation in idiopathic pulmonary fibrosis: a clinical case
48. Non invasive ventilation, Pulmonary rehabilitation and chest physiotherapy 1
49. Non invasive ventilation, Pulmonary rehabilitation and chest physiotherapy 2
50. Obesity Hypoventilation Syndrome
51. ELDERLY NON INVASIVE MECHANICAL VENTILATION APPLICATIONS
52. Elderly-NIV: Non-invasive mechanical ventilation treatment in elderly patient with usual interstitial pneumonia
53. Clinical case in Non Invasive Ventilation in End of life
54. Non invasive ventilation in Home mechanical ventilation
55. Comorbidities conditions impact (Renal failure/Liver failure/Neurologic) in non invasive mechanical ventilation
56. Clinical cases in Noninvasive Ventilation Clinical conditions - hypercapnic failure- Neuromuscular disorders
57. Clinical case in Noninvasive Ventilation Clinical conditions Respiratory care of neuromuscular disorders: a rare case of Charcot-Marie-Tooth disease (CMT2S)
58. Clinical case in Noninvasive Ventilation Clinical conditions hypercapnic failure- Neuromuscular disorders in amyotrophic lateral sclerosis
59. Noninvasive ventilation in Ventilatory Pump Failure: When is Oxygen Administration Deadly?
60. Clinical case in Non Invasive Ventilation . Ethical aspects of the palliative use
61. Clinical cases in Noninvasive Ventilation in Quality of life
62. Pediatric Non-Invasive Ventilation: Non-invasive ventilation treatment in a pediatric patient with catathrenia.

Contents:
1. Introduction
2. Paradigmatic shifts in the theory, practice and teaching of medicine in recent decades
3. Teaching behavioral and social sciences to medical students
4. Difficulties in learning and teaching patient interviewing
5. Overcoming difficulties in teaching patient interviewing
6. Doctor-patient relations
7. Barriers to doctor-patient communication
8. Diagnostic utility of the physical examination and ancillary tests
9. Physical-examination skills: learning difficulties
10. Learning and teaching physical-examination skills by clinical context
11. Recording the clinical data base
12. Recording personal and social data and examination of asymptomatic persons
13. Recording the patient's history
14. Intuitive vs analytic clinical reasoning
15. Should clinical training rely on role modeling?.

Contents:
Cardiology
Endocrinology
Gastroenterology
Hematology-Oncology
Infectious Disease
Intensive Care
Nephrology
Neurology
Pulmonary
Rheumatology.

Summary: This book discusses how effective navigation requires a team approach to oncology care and should never be considered an "add-on" resource or service. The Academy of Oncology Nurse & Patient Navigators (AONN) is the only national professional organization for navigation professionals, and has more than 6,000 members, 90% of which are oncology nurse navigators. They are the experts on creating team-based programs, which remove the risk of others trying to reinvent the wheel by designing a navigation program from scratch. They also understand the role of effective navigation across the entire continuum of care, and understand and are able to apply other key aspects of navigation, including clinical trial screenings and tumor board coordination and monitoring, as well as measurement using evidence-based navigation metrics, to name but a few.It is the only book designed to educate and support anyone developing a new navigation program, or wanting to improve one they have created.As such it offers a guide for cancer centers needing to develop and implement an oncology navigation program; understand and successfully meet and exceed the Commission on Cancer accreditation standards linked to navigation; expand or improve their current navigation program as well as demonstrate its value using reliable measurable results, including patient satisfaction and improved- quality clinical outcomes. This comprehensive book also provides insights into applying the information presented to the real world of oncology care.

Contents:
Historical background
Teamwork in theory
Teamwork in practice
Clinical teamwork
Team communication
Examples of team rehabilitation settings
Concluding discussion.

Summary: This book is a comprehensive guide to the application of recently introduced and emerging technologies in minimally invasive spine surgery (MISS). These technologies, including 2D and 3D navigation, endoscopy, virtual and augmented reality, robotics, and 3D printing, are helping to overcome previous limitations of MISS, such as the steep learning curve and the need for a great deal of experience in order to achieve optimal outcomes. Compared with traditional techniques, their use is designed to reduce local operative tissue damage, alleviate systemic surgical stress, and enable earlier return to function. The book provides detailed and extensively illustrated accounts of the role of the new technologies and techniques in a wide range of indications. In essence, all spine conditions, whether degenerative, traumatic, or oncologic, will in the near future be amenable to MISS using these approaches. The book will be a source of insight and practical assistance for all surgeons who perform MISS, regardless of their level of experience.

Summary: Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

Contents:
Rational for Focal Therapy
Concept of Index lesion
Definition and Principles of Focal Therapy
Eligibility for Focal Therapy: Patient Selection
Imagingfor Focal Therapy
Biopsies strategy
Focal Cryotherapy
Focal HIFU
Focal Brachytherapy
Focal PhotoDynamic Therapy
Focal Laser Thermal Therapy
Cyberknife Focal Therapy
New Energies
Follow-up after Focal Therapy
Failure or Recurrence Management
Focal Therapy Limitations
Perspective
Conclusion.

Contents:
The Artisan, the Sage and the Irony: An Outline of Knowledge Sociogenesis
Technicization of the Neurosciences: Uses of Image-Processing Software in Brain Research
Cryptography, a Human Science? Models, Matrices, Tools and Frames of Reference
The Beauty of Equation: The Anthropologist and the Engineer in Design Processes
Conclusion: Confrontations with Confusions: Stakes to be Re-established.

Summary: "In 1990, Dr. Kenneth Krackow wrote The Technique of Total Knee Arthroplasty to teach the basics of TKA for end-stage arthritis--everything from nonsurgical to surgical intervention and postoperative rehabilitation. Now completely revised for a new generation of surgeons, the 2nd Edition of this classic text continues its original goal of helping advanced practitioners acquire more knowledge and skill in primary and revision total knee arthroplasty. This fully updated volume, revised by Dr. Krackow and his former fellows Drs. William M. Mihalko and Michael A. Mont, keeps you current with major changes and advances in field, including patient optimization, outpatient procedures, robotics and new technology, difficult decisions during surgery, and more"-- publisher's description.

Summary: "Due to close collaboration between otorhinolaryngologists and neurosurgeons, endoscopic endonasal brain surgery has become part of the surgical armamentarium for successful treatment of various cranial base pathologies. Today, it is considered the gold standard surgical technique for many types of skull base tumors. Techniques and Key Points for Endoscopic Cranial Base Reconstruction by pioneering otorhinolaryngologist Carlos D. Pinheiro-Neto and neurosurgeon Maria Peris-Celda, co-editor of Thieme's acclaimed Rhoton's Atlas of Head, Neck, and Brain, encompasses the most important endoscopic cranial base reconstruction techniques performed in the last two decades. The book features contributions from an impressive group of additional experts in this field."--Provided by publisher.

Summary: "Cartilage defects are common. Cartilage repair surgery is not only fascinating but also surgically challenging. There are books dealing with basic science and some surgical aspect. This book fills a gap in surgical techniques for cartilage repair. All of the surgical chapters are logically organised, covering patient selection, patient setup/positioning, surgical approach, potential complications and troubleshooting. An attempt is made to compare with various surgical techniques. This book also covers anaesthesia, postoperative follow-up, pain management and rehabilitation. Both the editors and the authors are renowned experts in the field. This book will be invaluable for orthopaedic and sports medicine surgeons (consultants and training doctors) and is also of potential interest to physiotherapists, medical students, general practitioners, physical medicine and rehabilitation specialists, and rheumatology specialists."--Publisher's website.

Summary: This book comprehensively covers minimally invasive laparoscopic and robotic surgical techniques suitable for use in abdominal operations. Chapters describe relevant techniques for abdominal wall reconstruction, esophageal, bariatric, hepatobiliary, and colorectal surgery. Detailed step-by-step procedural guidance is provided with relevant photographic illustrations. Techniques in Minimally Invasive Surgery is a vital resource for surgeons who perform minimally invasive gastrointestinal operations. The book is particularly addressed to trainees, fellows, and junior faculty.

Summary: This book provides a guide to the surgical techniques required in thoracic surgery. Minimally invasive surgery (MIS) has become a standard surgical technique in the field of thoracic surgery recently. In addition, the evolution of video equipment and surgical instruments, and robotic devices lead to the rapid development of surgical techniques. Providing the latest and detailed surgical techniques and reviews of video-assisted thoracic surgery and robotic surgery in commonly performed thoracic surgery, and is expected to be of great help to thoracic surgeon who starts minimally invasive surgery.

Contents:
A.Lung
1. Establishment of Minimally Invasive Thoracic Surgery Program
2. Video-Assisted Thoracic Surgery wedge resection. 3. Video-Assisted Thoracic Surgery Lobectomy
4. Video-Assisted Thoracic Surgery Segmentectomy
5. Video-Assisted Thoracic Surgery Pneumonectomy
6. Video-Assisted Thoracic Surgery Mediastinal Lymph Node Dissection in Lung CancerSurgery
7. Management of Complications During Video-Assisted Thoracic Surgery Lung Resection and Lymph Node Dissection
8. Robot-Assisted Thoracic Surgery in Non-small Cell Lung Cancer
B. Esophagus
1. Video-Assisted Thoracic Surgery Esophagectomy
2. Video-Assisted Thoracic Surgery Intrathoracic Anastomosis Technique
3. Robot-Assisted Thoracoscopic Esophagectomy with Total Mediastinal
4. Lymphadenectomy: A Guide to a Systematic Approach Using the Concept of Fascial Plane Dissection
C. Thymectomy and others
1. Video-Assisted Thoracic Surgery Thymectomy: Transpleural Approach
2. Video-Assisted Thoracic Surgery Thymectomy: Subxiphoid Approach
3. Robot-Assisted Thoracic Surgery Thymectomy
4. Non-intubated Video-Assisted Thoracic Surgery
5. Non-conservative Management of Chylothorax.

Contents:
Chapter 1: Principles of Doppler ultrasound
Chapter 2: Carotid color duplex scanning
Chapter 3: Carotid interpretation
Chapter 4: Vertebral & subclavian artery imaging
Chapter 5: Venous anatomy and hemodynamics
Chapter 6: Venous duplex imaging : lower extremities
Chapter 7: Imaging methods for venous insufficiency
Chapter 8: Venous imaging of upper extremities
Chapter 9: Arterial hemodynamics, anatomy, and physiology
Chapter 10: Physiologic arterial testing : lower extremities
Chapter 11: Color duplex imaging : lower extremity arteries
Chapter 12: Arterial bypass grafts & stents
Chapter 13: Arterial evaluation of the upper extremities
Chapter 14: Hemodialysis access fistulas & grafts
Chapter 15: Transcranial Doppler
Chapter 16: Abdominal Doppler fundamentals
Chapter 17: Statistics & quality assurance
Chapter 18: Glossary
Lab and personal resources
Chapter-based educational exercises
CME post-test application information.

Contents:
Front Cover
Techniques in Ophthalmic Plastic Surgery
Copyright Page
Preface
Acknowledgments
Contents
Video Contents
1 The Art of Surgical Technique
Videos
Introduction
Preparation for the Operation
Firm Plan With Contingencies
Room Setup
Equipment Setup
Skin Marking and Local Anesthesia
Preparing and Draping The Patient
Instruments
Cutting the Skin
Hand Position
Scalpel Blades
Other Cutting Tools
Placement of Skin Incisions
Anxiety and Tremor
Cutting Tissue with Scissors
How do scissors cut?
Types Of Scissors Scissors Length
Scissors Caliber
Scissors Tips
Scissors Blade Design
Scissors Cutting Motion
Cutting With Scissors (You Learned this as a Child)
Retraction and Exposure
Fingers As Retractors
Skin Hooks
Forceps
Dissection Technique
Retractors
Hemostasis
Preoperative Considerations
Tamponade
Cautery
Bipolar Cautery
Unipolar Cautery
Bone Wax
Drugs
Drains
Suction
Suturing
Types Of Suture Material
Types Of Needles
Needle HolDers
Suturing Technique
Passing the Needle
Superficial and Deep Sutures
Tying the Suture The Surgical Assistant
Suggested Reading
2 Clinical Anatomy
VIDEO
Introduction
Periocular Anatomy
Skin Creases And Folds
Eyebrows
Eyelids
Orbital Bones
Orbital Rim
Bones of the Orbital Rim
Tripod fracture
Orbital Walls
Boundaries of the Walls
Blowout Fracture
Bones of the Orbital Walls
Fissures, Foramina, Grooves, and Canals
Periorbita
Muscles That Close the Eyes
Orbicularis Muscle
Corrugator And Procerus Muscles
Underactive Muscles: Facial Nerve Palsy Overactive Muscles: Orbicularis Myokymia, Facial Tics, Essential Blepharospasm, And Hemifacial Spasm
Canthal Tendons
Lateral Canthal Tendon
Slope of the Eyelid
Lower Eyelid Laxity: The Cause of Ectropion
Lateral Tarsal Strip Operation
Lateral Canthal Dystopia
Medial Canthal Tendon
Medial Canthal Tendon Laxity
Telecanthus
Muscles That Open the Eyes
Levator Muscle
Whitnall's Ligament
Horns of the Levator Aponeurosis
Müller's Muscle
Ptosis Of The Upper Eyelid
Frontalis Muscle
Lower Eyelid Retractors
Involutional Entropion
Horner Syndrome Preaponeurotic Fat and the Orbital Septum
Preaponeurotic Fat
Orbital Septum
Conjunctiva
Bulbar, Palpebral, And Fornix Conjunctiva
Diseases Of The Conjunctiva
Anterior And Posterior Lamellae Of The Eyelid
Lacrimal System
Tear Film
Lacrimal Gland
Lacrimal Drainage System
Puncta
Canaliculi
Lacrimal Sac
Nasolacrimal Duct
Lacrimal Pump
Nasal Anatomy
Anatomy of the Paranasal Sinuses
Ethmoid Sinus
Frontal Sinus
Maxillary Sinus
Sphenoid Sinus
Innervation to the Periocular Area
Sensory Innervation

Contents:
1. Wrist arthroscopy portals
2. Trapeziometacarpal and scaphotrapezial arthroscopy portals
3. Triangular fibrocartilage tears
4. Foveal tears and arthroscopy of the distal radioulnar joint
5. Ulnocarpal impaction syndrome and ulnar styloid impaction syndrome
6. The role of wrist arthroscopy in scapholunate instability
7. Lunotriquetral injuries: Arthroscopic management
8. Arthroscopic management of dorsal radiocarpal ligament tears
9. The role of arthroscopy in midcarpal instability
10. Arthroscopic treatment of scaphoid fractures and nonunions
11. Arthroscopic treatment of distal radius fractures
12. Arthroscopic treatment of intraarticular malunions of the distal radius
13. The role of arthroscopy in perilunate injuries
14. Arthroscopic wrist capsulotomy
15. Arthroscopy in arthritis
16. The use of arthroscopy in kienböck disease
17. Arthroscopic wrist ganglionectomy
18. Arthroscopic radial styloidectomy
19. Arthroscopic partial scaphoidectomy for scaphoid nonunion
20. Arthroscopic partial wrist fusions --21. Arthroscopic proximal row carpectomy
22. Metacarpophalangeal joint arthroscopy
23. Arthroscopic treatment of first metacarpal base fractures
24. Arthroscopic reduction and percutaneous fixation of fifth carpometacarpal fracture dislocations --25. Arthroscopic treatment of trapeziometacarpal osteoarthritis
26. Arthroscopic treatment of scaphotrapeziotrapezoidal osteoarthritis.

Contents:
PART I. General
1. The Economics of Hernia Surgery
2. Surgical anatomy of groin and groin hernia
3. Abdominal wall hernia classification
4. Imaging techniques for abdominal wall hernias
5. Future Consideration
PART II. Groin Hernia
6. Biomaterials for Inguinal Hernia Repair
7. Anaesthesia for Laparoscopic Abdominal Wall Hernia Repair
8. Surgical techniques for Inguinal hernia repair: Open Technique
Tissue repairs
9. Surgical techniques for inguinal hernia repair: open tension-free repairs
10. Total extra-peritoneal repair (TEP)
11. Trans-abdominal pre-peritoneal repair (TAPP)
12. Open and Laparoscopic Repair of Femoral Hernia
PART IIII. Abdominal Wall Hernia
13. Biomaterials For Abdominal Wall Hernia Repair
14. Components Separation Technique For Repair Of Complex Abdominal Wall Hernia
15. Laparoscopic Incisional And Ventral Hernia Mesh Repair
16. Laparoscopic repair of Peripheral Abdominal Wall Hernias
17. Laparoscopic Pre-peritoneal Onlay Mesh (PPOM) repair for ventral and incisional hernia
18. Muscle- aponeurotic plication associated with dermolipectomy in the treatment of ventral hernias and recti diastasis
A functional and aesthetic approach
19. Minimally invasive subcutaneouscopic and robotic rectus plication
20. Parastomal Hernia
21. Complications inguinal hernias: Strangulated incarcerated and obstructed hernias
22. Sportsman Hernia
23. Groin Hernia In The Elderly
24. Obesity and Abdominal wall hernias
25. Recurrent Inguinal Hernia.

Summary: "Hearing, health and technologies are entangled in multi-faceted ways. The edited volume addresses this complex relationship by arguing that modern hearing was and is increasingly linked to and mediated by technological innovations. The volume will be of interest to all scholars and students of disability studies, sound studies, sociology of health and illness, medical history, health and society as well as those interested in the practices and techniques of self-monitored and smart hearing"-- Provided by publisher.

Summary: This book provides a complete and thorough guide to the performance of robotic urinary tract reconstruction procedures, including the principals of successful reconstructive techniques in the kidney, ureter, bladder, prostate and urethra. Reviewing patient positioning, trocar placement, instrumentation, detailed steps of procedure, and available outcome data, it outlines both common and advanced techniques, such as revision of uretero-intestinal anastomoses, buccal mucosa graft for long segment ureteral strictures, management of complex fistulas and urethral stricture. Illuminating unusual anatomy, including horseshoe kidney, retrocaval ureter, ureteral duplication, ectopic/malrotated kidneys, and retroperitoneal fibrosis, this book also highlights potential complications, their avoidance and management. Written by experts in the field, Techniques of Robotic Urinary Tract Reconstruction: A Complete Approach guides clinical practitioners in the utilization of advanced novel technology to aid intraoperation and demonstrates the ways in which robotics enables the performance of reconstructive procedures in an area difficult to reach via open techniques.

Contents:
Why Robotic Surgery?
Keys for Intraoperative Success: Principles of Urinary Tract Reconstruction
Principles of Reconstruction: Spatulation, Blood Supply, Wound Healing
Tissue Substitution in reconstruction: Graft, Flaps
Adult Robotic Pyeloplasty
Pediatric Robotic Pyeloplasty
Managing Stones; Unusual Anatomy in a Patient with UPJ Obstruction
Recurrent Ureteropelvic Junction Obstruction
Proximal Ureteral Reconstruction: Ureteo-Ureterostomy, Buccal Mucosa Graft, Retrocaval Ureter
Ureteral Reconstruction– An Overview of Appendiceal Interposition and Ureterocalicostomy
Robotic Renal Autotransplantation and Ileal Ureter
Ureterolysis and Boari Flap
Proximal and Mid-Ureteral Reconstruction in the Pediatric Population
Diagnosis, Evaluation and Preoperative Considerations in Distal Ureteral Reconstruction
Robot-Assisted Reconstructive Surgery of the Distal Ureter
Distal Ureteral Injury and Repair in Children
Distal Ureteral Reconstruction in Children
Adult Bladder Diverticulectomy and Partial Cystectomy
Pediatric Bladder Augmentation and Urinary Diversion
Robot-Assisted Laparoscopic Bladder Surgery for Nonmalignant Conditions in the Pediatric Patient (Bladder Diverticulectomy, Urachal Cyst Excision, and Cystolithotomy)
Surgical Complications after Robot-Assisted Radical Cystectomy
Orthotopic Ileal Neobladder and Continent Catheterizable Urinary Diversion
Robotic-Assisted Ileal Conduit Urinary Diversion
Urinary Diversion: Robot-Assisted Laparoscopic Malone Antegrade Continence Enema (MACE) and Mitrofanoff Appendicovesicostomy (MAPV)
a. simple prostatectomy
Robotic Assisted Laparoscopic Bladder Neck Reconstruction
Robot-Assisted Bladder Neck Artificial Urinary Sphincter Implantation
Rectourethral and Colovesical Fistula
Ureter-Vaginal Fistula
Robotic Management of Vesicovaginal Fistulas
Posterior Urethroplasty.

Summary: "Technological Addictions is the first guide designed to provide insight and strategies to clinicians, patients, and families grappling with the collateral damage of technology's pervasiveness and pull. Mental health professionals are beginning to understand that video games, online pornography, internet gaming, internet gambling, and other technological pastimes can be every bit as addictive as substances such as alcohol, tobacco, and illicit drugs. Editor Petros Levounis is among the foremost experts on addiction and, together with coeditor James Sherer and a roster of prominent contributors, has created a groundbreaking book that emphasizes the lived reality of the people who struggle with these addictions every day. In 10 rigorous yet down-to-earth chapters, the book explores the psychological and cultural context of each technology and related behavior, from social media to cybersex, and examines thoroughly the difference between healthy engagement with technology and addiction. This discussion premised on the understanding that technology should not be rolled back or restricted but is an increasingly beneficial and even necessary part of modern life. Two chapters specifically focus on the way technology addictions impact particular populations, such as children and adolescents and older adults. Addiction to technology does not discriminate; no preexisting psychological or physical conditions are required, and everyone is susceptible. Technological Addictions provides guidance found nowhere else, guidance that both clinicians and laypeople will find useful and compelling"-- Provided by publisher.

Contents:
Video Games : From Harmless Pastime to Internet Gaming Disorder / James Sherer
Cybersex and Online Pornography : Hacking the Human Sex Drive / Lancer Naghdechi, Muhammad Aadil, Faisal Kagadkar, Petros Levounis
Internet Gambling : An Old Behavior in a New Age / Robert Rymowicz
Texting, Emailing, and Other Online Messaging : When Does a Communication Tool Become a Burden? / Heather Wurtz, Donya Nazery
Internet Surfing and Information Overload / Diego Garces Grosse
Social Media : The Self vs. the Selfie / Lukman-Afis (Lukmon) Babajide
Online Shopping and Auctions : The Ease and Sleaze / Faisal Kagadkar, Ana Claudia Zacarkim Pinheiro dos Santos, Lancer Naghdechi
Children and Adolescents : Codependence Between Youth and Tech / Muhammad Aadil, Aitzaz Munir, Lancer Naghdechi, Yonatan Kaplan
Special Considerations for Older Adults / Seyed Parham Khalili
New and Emerging Addictive Technologies : Where Do We Go From Here? / Rafael Coira.

Summary: The book explores how kidney disease care is being changed by new technologies, from inception and diagnosis to dialysis and kidney transplant. Massive technological advances have affected health care in the past decade, and doctors are moving quickly to change the way we provide care for kidney diseases. We are rapidly shifting from hospital- and clinic-based systems to providing care at home, with technologies that help monitor care and intervene remotely. Some of the technologies covered include genetic testing for diagnostic and therapeutic purposes, metabolism/ezposome assessment, AI-driven tool for drug dosing, and apps available to patients. This book aims to educate providers on the many new scientific and technological interventions that can help monitor and mitigate kidney disease.

Contents:
Ther New Surgeon: Patient-Centered, Disease-Focused, Technology-Driven, and Team-Oriented
The Ever-Changing Departments of Surgery: The New Paradigm-The Roadmap to a Modern Department of Surgery
Genomics in Surgery, Trauma, and Critical Care: How Do We Control the Future?
Nanotechnologies in Surgery: The New Paradigm
Telemedicine for Trauma and Intensive Care: Changing the Paradigm of Telepresence
Augmented Reality in Surgery
The Lean Innovation Model for Academic Medical Discovery
Changing the Protocol: Is There Still Room for the Professor's Viewpoint?
Ethical Implications of Advanced Technologies in Surgical Care. Dedicated Resuscitation Operating Room for Trauma
End Points Resuscitation
Abdominal Trauma: Not Everything that Bleeds Needs and Operation
Neurosurgical Advances in Trauma Management
Damage Control and Organ Injury Priority Management of Trauma Patients
Multiorgan Dysfuction in Trauma and Surgical Intensive Care Units
Advances in Burn Care
Biology of Nutrition Support and Gut Access in Critically Ill Patients
Advances in Head and Neck Surgery
Neck Cancer: Imaging Techniques and Progress on the Operative Approach
Advances in Thyroid and Parathyroid Care
Neuron Based Surgery: Are We There Yet? Technical Developments in the Surgical Treatment of Brain Injury and Disease
Brain Cancer: The New Frontiers
Advanced Thoracoscopic Surgery to Modern Pulmonary Disease: The Japanese Approach
The Role of Robotics in Selective Throacic Surgical Problems: Technical Considerations
Cardiac Surgery Advances: Do We Still Remember How to Do Open Bypass?
Artificial Hearts and Cardiac Assist Devices: The Spectrum of the New Era
New Valves: Where Do We Stand?
Technological Advances in Endovascular Surgery
Carotid Disease: The Stents and the Evidence-Based Medicine-What Happened to the Old Surgery?
Laporascopic Approaches in General Surgery: Is There Anything New?
Robotic Applications in Advancing General Surgery
Natural Orifice Transluminal Endoscopic Surgery (NOTES)
Bariatric Surgery: The Less, The Better
New Minimally Invasive Treatments for Acid Reflux
Minimally Invasive Hepato-Pancreato-Biliary Surgery and Associated GI Interventions
Pancreatic Advances
Laparoscopic Liver Resection for Hepatocellular Carcinoma
Advances in Colorectal Surgery
Technological Advances in Heart and Lung Transplantation: Concomitant Cardiac Valve Surgery
Abdominal Organ Transplantation: An Overview
Small Bowel Transplantation: Is There a Hope on the Horizon?
Islet Cell Transplantation: New Techniques for an Old Disease
Face Transplant: The Future is Better Than Current Concepts
Limp Transplantation
Advances in Immunosuppressive Therapy
Tissue Repair and Wound Healing: A Trip Back to the Future
Surgical Advances in the Treatment of Abdominal Wall Hernias
Use of Biologic Grafts in Surgery
Artifical Limbs for Upper Extremity Amputation
Advanced Technologies in Pediatric Critical Care/Surgery and Fetal Surgery.

Contents:
Glycemic control
Home blood glucose monitoring
Continuous glucose monitoring
Insulin delivery system
Closed-loop insulin-delivery system
Alternatives to insulin injection
Devices to support treatmtne decisions
Electronic medical record.

Summary: Global climate change is one of the most serious threats to the environment of the earth and to the crop production. Crop vulnerability to climate change stress caused by the greenhouse gases emission is a serious concern. This book describes various technologies and methods including the simulation of the future climate changes, studying the response of crop plants and characterizing their responses physiologically and biochemically. It includes the latest information of protocols and technologies for climate change research on agriculture. This book is of interest to teachers, researchers, climate change scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists, policy makers will also find this to be a useful read.

Contents:
Intro
Foreword
Preface
Acknowledgements
Contents
About the Authors
Abbreviations
1: Introduction
1.1 General Introduction
1.2 Importance of Technologies in Climate Change Research on Agriculture
1.3 Summary
References
2: Carbon Dioxide
2.1 Measurements of Carbon dioxide (CO2) in the Atmosphere, Soil and Agricultural Crops
2.1.1 Infrared Gas Analysis
2.1.2 Eddy Covariance Technique
Components of Eddy Covariance System
Major Components Used in Eddy Covariance Technique
Sonic Anemometer
Data Storage
Power Supply
Flux Calculations Enteric Tracer Ratio
External Tracer Ratio
Mass Balance from Barns
3.1.4 Micrometeorological Techniques
Mass Balance
Integrated Horizontal Flux (IHF)
Modified Mass Difference (MMD) Approach
Vertical Flux Techniques
Eddy Covariance (EC)
3.2 Modelling Techniques
3.3 Mitigation Technologies
3.3.1 Potassium Amendment
3.3.2 Midseason Drainage
3.3.3 Alternate Wetting and Drying (AWD) Technology
3.3.4 Nitrogen Fertilizer on Methane Emissions
3.3.5 Biocovers of Landfills
3.3.6 Biological Aspect of the Amendment of Methanogenic Activity Land-Based Enhanced Rock Weathering Method of Carbon Sequestration:
2.4.2 Zero-Tillage
2.4.3 Agroforestry
2.4.4 Crop Residue Management
2.4.5 Biofuels
2.4.6 Biochar
2.4.7 Mycorrhiza
2.4.8 Microalgae
2.4.9 Organic Agriculture
2.5 Summary
References
3: Methane
3.1 Technologies Associated with Methane (CH4) Emission and Crop Response Studies
3.1.1 Measurements of Methane Emission in Stationary Mode
3.1.2 Fourier Transform Infrared Spectroscopy (FTIR)
3.1.3 Non-micrometeorological Techniques
Chamber Techniques:
Calculation of Methane Flux Measurements Using Eddy Covariance Flux Towers
Limitations
2.1.3 Gas Chromatography
2.1.4 Spectroscopic Methods
2.1.5 Carbon Stock Measurement Technique
2.1.6 Wet Digestion
2.1.7 Dry Combustion
2.1.8 Dry Combustion in an Elemental Analyser
2.1.9 Fractionation of Soil Organic Carbon
2.1.10 Physical Fractions
2.1.11 Chemical Fractionation
2.1.12 Spectroscopic Method
2.1.13 Laser-Induced Breakdown Spectroscopy (LIBS)
2.1.14 Inelastic Neutron Scattering (INS)
2.1.15 CO2 Emission Measurement from Soil: Quantitative Approach
Alkali Trap Method Soil Respirator Method
Infrared Gas Analysis Method
Closed-Chamber Method
2.1.16 Space-Borne Measurements
2.2 Technologies Associated with CO2 Enrichment Studies (Crop Response Studies)
2.2.1 Leaf Cuvettes
2.2.2 Sunlit-Controlled Environment Chambers
2.2.3 Soil Plant Atmosphere Research (SPAR) System
2.2.4 Portable Field Chamber
2.2.5 Open-Top Chamber
2.2.6 Screen-Aided CO2 Control (SACC)
2.2.7 Free Air CO2 Enrichment Technology (FACE)
2.3 Modelling Techniques
2.4 Mitigation Technologies
2.4.1 Carbon Sequestration

Summary: This comprehensive book provides a framework for healthcare providers working with the dual challenges and opportunities presented by the intersection of mental health and technology. Technology and Adolescent Mental Health provides recent, evidence-based approaches that are applicable to clinical practice and adolescent care, with each chapter including a patient case illustrating key components of the chapter contents. Early chapters address the epidemiology of mental health, while the second section of the book deals with how both offline and online worlds affect mental health, presenting both positive and negative outcomes, and focusing on special populations of at-risk adolescents. The third section of the book focuses on technology uses for observation, diagnosis or screening for mental health conditions. The final section highlights promising future approaches to technology, and tools for improving intervention and treatment for mental health concerns and illnesses. This book will be a key resource for pediatricians, family physicians, internal medicine providers, adolescent medicine and psychiatry specialists, psychologists, social workers, as well as any other healthcare providers working with adolescents and mental health care.

Contents:
Part I Epidemiology of mental health and technology
An overview of adolescent mental health / Henry Berman
Adolescents seeking online health information: Topics, approaches, and challenges / Jason B. Colditz, Michelle S. Woods, and Brian A. Primack
How mental health conditions affect online use and access / Yolanda N. Evans
Technology use among special populations / Allison Schimmel-Bristow and Kym R. Ahrens
Part II Associations between mental health symptoms and technology use
Positive and negative associations between adolescent mental health and technology / Linda Charmaraman, Tracy Gladstone, and Amanda Richer
Social media use and display of depressive symptoms online by adolescents and young adults / Ana Radovic, Olga Santesteban-Echarri, Mario Álvarez-Jiménez, John Gleeson, Simon M. Rice, and Megan A. Moreno
Cyberbullying and mental health / Rajitha Kota and Ellen Selkie
Media multitasking and mental health / Nancy A. Cheever, Kristin Peviani, and Larry D. Rosen
Internet gaming disorder / Jeffrey N. Rokkum, Jorge A. Blanco-Herrera, Manuela E. Faulhaber, and Douglas A. Gentile
When does internet and smartphone use become a problem? / Nancy A. Cheever, Megan A. Moreno, and Larry D. Rosen
Part III Use of technology for diagnosis, intervention, and treatment
Identifying symptoms using technology / Afsaneh Doryab
Social media data for online adolescent suicide risk identification: Considerations for integration within platforms, clinics, and schools / Molly Adrian and Aaron R. Lyon
Telemental health / Jennifer Mc Williams and Kathleen Myers
Social media interventions for adolescents and young people with depression and psychosis / Olga Santesteban-Echarri, Mario Álvarez-Jiménez, John Gleeson, and Simon M. Rice
The role of texting in addressing mental health / Megan L. Ranney, Anthony R. Pisani, and Lauren S. Chernick
Online therapy for adolescent mental health / Huma Ali Khan, Karen Bernstein, and Benjamin Van Voorhees
Video games and their impact on teens' mental health / Melissa E. DeRosier and James M. Thomas
Apps for mental health / Oliver Lindhiem and Jordan L. Harris
Comprehensive approaches using technology to address mental health / Scottye J. Cash, Stephanie Craig Rushing, and David Stephens.

Summary: This book explores the pivotal role played by technology over the past decade in advancing global public health and health care. At present, the global community faces unprecedented healthcare challenges fueled by an aging population, rising rates of chronic disease, and persistent health disparities. New technologies and advancements have the potential to extend the reach of health professionals while improving quality and efficiency of service delivery and reducing costs within the public and the private health systems. The chapters highlight the barriers faced by the global healthcare workforce in using technology to promote health and human rights of communities: Role of Digital Health, mHealth, and Low-Cost Technologies in Advancing Universal Health Coverage in Emerging Economies Telehealth and Homecare Agencies Technology and the Practice of Health Education in Conflict Zones The Worldwide Digital Divide and Access to Healthcare Technology Technology for Creating Better Professional Teams to Strengthen Healthcare Systems Global Public Health Disaster Management and Technology As a resource on the evolution of technology as a valuable and integral component in the promotion and practice of public health and health care, with a focus on SDG 3 targets, Technology and Global Public Health should engage students, instructors, practitioners, and other professionals interested in public health, universal health care, health technology, digital health, and health equity. Dr. Murthy has been a respected leader and mentor on scientific health-related matters within the UN system for many years. Her book develops a theoretical system connecting concepts that have coined global public health with the rapid development of technology, all with the focus to achieve Sustainable Development Goal number three, within the time frame set by World Leaders. - Henry L. Mac-Donald, Former Permanent Representative of Suriname to the United Nations.

Contents:
Preface
Part I: Reflections
Space and Global Health
Universal Health Coverage in Japan: Leveraging Technologies to Ensure Equitable, Affordable, and Quality Health Care for All
Georgia's Success Towards Universal Health Coverage
Women, Girls, and STEM
Role of New Media in Advancing Gender Equality
Part II: Technology in Advancing Health: Meeting Sustainable Development Goal 3 Targets
Chapter 1. Role of Digital Health, mHealth, and Low-Cost Technologies in Advancing Universal Health Coverage in Emerging Economies
Chapter 2. Social Media and the Practice of Public Health
Chapter 3. The Role of Technology in Women's Empowerment and Well-Being and Addressing Gender-Based Violence
Chapter 4. Telehealth and Homecare Agencies
Chapter 5. Health Transformation in Saudi Arabia via Connected Health Technologies- Chapter 6. Simple Technology for Menstrual Hygiene Management: A Case Study from Northern Ethiopia
Chapter 7. Technology and the Practice of Health Education in Conflict Zones
Chapter 8. Law, Technology, and Public Health
Chapter 9. mHealth for Better Quality of Life, Healthier Lifestyles, and More Meaningful Lives
Chapter 10. Digital Health Transforming Health Care in Rural and Remote Australia
Chapter 11. Telehealth and Traumatic Brain Injury
Chapter 12. Leveraging Technology for Attaining Sustainable Development Goal 3: The Road Ahead
Part III: Types of Innovative Technology in Health Care
Chapter 13. Technology vs. Mercury: The Metal that Scars Civilization
Chapter 14. Trafficking, Technology, and Public Health: The Malignant Malady of Modern Slavery
Chapter 15. The Worldwide Digital Divide and Access to Healthcare Technology
Chapter 16. Technology for Creating Better Professional Teams to Strengthen Healthcare Systems
Chapter 17. Global Public Health Disaster Management and Technology
Chapter 18. Employing Data Science Technologies Towards Shaping a Sustainably Healthy Future: The Efforts in Contemporary Taiwan
Chapter 19. Telemedicine in India and Its Impact on Public Health
Chapter 20. The Role of Technology in Sustainable Development Goal Performance in Taiwan
Chapter 21. Reducing the Burden of Oral Diseases Through Technology
Chapter 22. Future and Impact of Rehabilitation Robotics on Post-Stroke Care and Recovery
Epilogue.

Summary: This book provides a complete overview on the latest available technologies in dermatology, while discussing future trends of this ever-growing field. This handy guide provides clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today. It also includes a section on imaging techniques for the evaluation of skin tumors, with chapters devoted to dermoscopy, in vivo and ex vivo reflectance confocal microscopy, high frequency ultrasound, optical coherence tomography, and a closing part on latest approaches to wound management. Completed by over 200 clinical images, Current Technology in Practical Dermatology: Non-Invasive Imaging, Lasers and Ulcer Management is both a valuable tool for the inpatient dermatologist and for physicians, residents, and medical students in the field.

Contents:
Foreword
Preface
Section I
Imaging techniques for the evaluation of skin diseases
1. Dermoscopy: fundamentals and technology advances
2. Dermoscopy for benign melanocytic skin tumors
3. Dermoscopy for Melanoma
4. Dermoscopy for non-melanocytic benign skin tumors
5. Demoscopy for non-melanocytic malignant skin tumors
6. Dermoscopy for inflammatory diseases
7. Dermoscopy for infectious diseases
8. Digital dermoscopy analysis
9. Optical super-high magnification dermoscopy
10. Fluorescence videodermoscopy
11.Total body photography and sequential digital dermoscopy for melanoma diagnosis
12. History and Fundamentals of Reflectance Confocal Microscopy
13.In vivo reflectance confocal microscopy for benign melanocytic skin tumors
14. In vivo reflectance confocal microscopy for melanoma
15. In vivo reflectance confocal microscopy for non melanocytic benign skin tumors
16. In vivo reflectance confocal microscopy for non melanocytic malignant skin tumours
17. In vivo Reflectance Confocale Microscopy for Inflammatory Diseases
18. In vivo reflectance confocal microscopy for infectious diseases
19. In vivo reflectance confocal microscopy for mucous membranes
20. Ex vivo confocal microscopy
21. Ultrasound
22. Optical coherence tomography
23. High-Definition optical coherence tomography
24. 3D imaging
25. Raman spectroscopy
26. Multispectral and Hyperspectral Imaging for skin acquisition and analysis
27. Electrical impedance in dermatology
Section II
Lasers and light sources technologies in dermatology
28. Laser Light and Light-tissue Interaction
29. Laser and light sources: safety and organization issues
30. Intense polichromatic lights and light emitting diodes:what's new
31. Vascular lasers: tips and protocols
32. Broadband intense pulsed lights for vascular malformations
33. Pigment specific lasers for benign skin lesions and tattoos: long pulsed, nanosecond and picos econd lasers
34. Skin resurfacing: ablative and non-ablative lasers
35. Photorejuvenation: concepts, practice, perspectives
36. Laser hair removal: updates
37. Biophotonic therapy induced photobiomodulation
38. Photodynamic Therapy
Section III
Technological advances in wound management
39. Temporary dressing
40. Extracellular matrices
41. Skin bank bioproducts: the basics
42. Clinical applications of skin bank bioproducts
43. Negative Pressure Wound Therapy
44. Tissue Engineered skin substitutes
45. Biologics in Wound Management
46. Stem Cell in Wound Healing
Section IV
New complementary tools for dermatologic diagnosis
47. Microbiopsy in dermatology
48. Noninvasive genetic testing: adhesive patch-based skin biopsy and buccal swab
49. Liquid biospsies.

Contents:
1. An introduction to the third dimension for routine cell culture
Part I. Aggregate-Based Technologies
2. Gravity-enforced microtissue engineering
3. Physiologically relevant spheroid models for three-dimensional cell culture
4. NanoCulture Plate: a scaffold-based high-throughput three-dimensional cell culture system suitable for live imaging and co-culture
5. Micro-moulded non-adhesive hydrogels to form multicellular microtissues- the 3D petri dish
6. Organotypic microtissues on an air-liquid interface
Part II. Hydrogels
7. Materials and assay systems used for three-dimensional cell culture
8. HyStem, a customisable hyaluronan-based hydrogel matrix for 3D cell culture
9. 3-D life biomimetric hyrdogels: a modular system for cell environment design
Part III. Scaffolds
10. Alvetex, a highly porous polystyrene scaffold for routine three-dimensional cell culture
11. CelluSponge and Go Matrix as innovative three-dimensional cell culture platforms
12. Mimetix electrospun scaffold: an easy-to-use tool for 3D cell culture in drug discovery and regenerative medicine
Part IV. 3D Bioreactor Technologies
13. Quasi Vivo bioreactor technology
14. Three-dimensional cell-based assays in hollow fibre bioreactors
15. Three-dimensional engineered tissues for high-throughput compound screening: mechanical properties of skin and ageing
16. Three-dimensional cell culture in the Rotary Cell Culture System
Glossary
Index.

Summary: "Show me your teeth," the great naturalist Georges Cuvier is credited with saying, "and I will tell you who you are." In this shattering new work, veteran health journalist Mary Otto looks inside America's mouth, revealing unsettling truths about our unequal society. Teeth takes readers on a disturbing journey into America's silent epidemic of oral disease, exposing the hidden connections between tooth decay and stunted job prospects, low educational achievement, decreased social mobility, and the troubling state of our public health. Otto's subjects include the pioneering dentist who made Shirley Temple and Judy Garland's teeth sparkle on the silver screen and helped create the all-American image of "pearly whites"; Deamonte Driver, the young Maryland boy whose tragic death from an abscessed tooth sparked congressional hearings; and a marketing guru who offers advice to dentists on how to push new and expensive treatments and how to keep Medicaid patients at bay. In one of its most disturbing findings, Teeth reveal that toothaches are not an occasional inconvenience, but rather a chronic reality for millions of people, including disproportionate numbers of the elderly and people of color. Many people, Otto reveals, resort to prayer to counteract the uniquely devastating effects of dental pain. Otto also goes back in time to understand the roots of our predicament in the history of dentistry, showing how it became separated from mainstream medicine, despite a century of growing evidence that oral health and general bodily health are closely related. Muckraking and paradigm-shifting, Teeth exposes for the first time the extent and meaning of our oral health crisis. It joins the small shelf of books that change the way we view society and ourselves - and will spark an urgent conversation about why our teeth matter. -- from dust jacket.

Contents:
Part I. Bad Teeth: Beauty
Suffering
Emergencies
The world beneath our noses
Part II. Dental Art: The birth of American dentistry
Separate lives
Adventurers and auxiliaries
The system
Color lines
Part III. A Sentinel Event: Deamonte's world
Riding into the epidemic
Sons and daughters of Chapin Harris.

Contents:
1 Introduction
2 Overview and Background
PART I
Fields of application 3 The community: Early diagnosis and prevention
4 The hospital: Improving hospital care for people with cancer
5 Home-based care for a better quality of life: Treatment, monitoring and follow-up
PART II
Technical Issues 6 New technologies and new frontiers
7 The social web
PART III
Complex Scenarios and Special Settings
8 Rural and extreme rural settings
9 Tele-oncology in developing countries
PART IV
eLearning 10 Education and distant learning
11 Health education to improve prevention
12 Conclusions.

Summary: A timely, practical, and concise resource for advanced practice registered nursing (APRN) students, faculty, and providers, Telehealth Essentials for Advanced Practice Nursing provides readers with an understanding of and tools to embrace the emerging field of telehealth and optimize its application in clinical practice.

Contents:
Telehealth nursing / Patty Alane Schweickert, DNP, FNP-C
Telehealth basics / Rebecca A. Bates, DNP, FNP-C, Kristi Henderson, DNP, FNP-BC, FAAN, FAEN, and Carolyn M. Rutledge, PhD, FNP-BC
Building blocks of nursing telehealth education : the multimodal approach / Carolyn M. Rutledge, PhD, FNP-BC, Katherine E. Chike-Harris, DNP, APRN, CPNP-PC, NE, Susan V. Brammer, PhD, RN, CNE, and Patty Alane Schweickert, DNP, FNP-C
Telehealth technology / Richard L. Rose II, CTC, CWTS, Patty Alane Schweickert, DNP, FNP-C, David Cattell-Gordon, MDiv, MSW, Samuel Collins, MSc, Rebecca L Steele, MSN, RN, CNL, Christianne Nesbit, DNP, AGNP, PMHNP, Michele L. Bordelon, MSEd, and Brian Gunnell, BS, CTC
Legal and regulatory issues in telehealth / Karen S. Rheuban, MD and Kathy H. Wibberly, PhD
The role of the Advanced Practice Registered Nurse in implementing telehealth practice / Katherine E. Chike-Harris, DNP, APRN, CPNP-PC, NE
Advanced Practice Registered Nurse telehealth practice modalities / Patty Alane Schweickert, DNP, FNP-C, Lynn Wiles, PhD, RN, Katherine E. Chike-Harris, DNP, APRN, CPNP-PC, NE, R. Lee Tyson, DNP, PMHNP-BC, ANP-BC, Tonya L. Hensley, DNP, FNP, Kathryn B. Reid, PhD, FNP-C, Rosalyn Perkins, MNSc, CNP, WHNP-BC, Rebecca A. Bates, DNP, FNP-C, S. Craig Thomas, MSN, NP, ACNP-BC, ACNS-BC, CHFN, Teresa Gardner Tyson, DNP, FNP-BC, Brian Myers, MBA, MTS, and Allison Kirkner, MSN, RN, ACNP-BC
Telehealth competencies : knowledge and skills / Carolyn M. Rutledge, PhD, FNP-BC, Tina Gustin, DNP, CNS, and Patty Alane Schweickert, DNP, FNP-C
Telehealth and interprofessional collaboration / Carolyn M. Rutledge, PhD, FNP-BC, and Tina Gustin, DNP, CNS.

Summary: "Offering significant benefits to both healthcare providers and patients, telehealth is a key component in the future of urology and patient care. Telehealth in Urology is a step-by-step, illustrated guide for clinicians who are beginning a telehealth offering or are interested in adopting new digital technologies--all specific and relevant to today's urology practice. It covers the key information you need to know--from necessary equipment to the practice team--with clear explanations of how you can best use telemedicine to provide timely, effective care to every patient"-- publisher's description.

Summary: "Success with telemedicine rests upon five essential pillars: 1. Patient success. Patients need to receive teh quality of care they desire, in the way they prefer. 2. Clinician success. Clinicians and organizations need to provide quality care in a way that works for them. 3. Technology success. Telehealth technology must work well and be easy to use. 4. Financial success. Clinicians, payers, and patients need to benefit financially from using telehealth. 5. Compliance success. Clinicians need to stay out of legal trouble and use healthcare laws and regulations to their advantage. Using a combination of personal stories, compelling research, and telehealth data, Drs. Welch and Joshi show how to be successful with telehealth across all five domains." -- inside book jacket.

Contents:
Section 1: Patient success
Patient access
Quality of care
Patient experience
Section 2: Clinician success
Clinical impact on workforce
Remote care delivery
Organizational success
Implementation
Section 3: Technology success
Selecting the right technology
Technology components
EHR integration
Section 4: Financial success
Medicaid and Medicare
Government-led healthcare
Private payers
Costs
Section 5: Compliance success
Malpractice
Fraud
Prescribing laws
Patient privacy
Information privacy
Information security
Medical boards
Organizational compliance.

Summary: This volume provides a comprehensive, state-of-the art review of inflammatory bowel disease and its management through the use of telemedicine applications. The book reviews barriers to successful outcomes in patients with IBD and offers a rationale for how self-management and telemedicine approaches can improve care in chronic illnesses such as IBD. This volume also includes a summary of the burden of telephone encounters in patients with IBD, characteristics of frequent callers to the office, outcomes associated with high telephone use, and strategies to provide education via telephone to patients with IBD. Prior literature on implementation of teleconsultation in research and clinical practice, as well as mobile applications used to track symptoms, quality of life, diet, and medication use in IBD are also explored in the book. Written by experts in the field, Telemanagement of Inflammatory Bowel Disease is a valuable resource for gastroenterologists, surgeons, and other clinicians dealing with, and interested in, this novel adjunct to routine care for inflammatory bowel disease.

Contents:
Barriers to Successful Outcomes in Patients with Inflammatory Bowel Diseases
Experience with Telemedicine Systems in Chronic Illness: What Can We Learn?
Telephone Encounters in Inflammatory Bowel Disease Care: Burden, Risk Factors, and Opportunities for Intervention
Teleconsultation in the Care of Patients with IBD
Self-Management Techniques in IBD
Mobile Applications for Patients with Inflammatory Bowel Disease
Telemonitoring and Self-Care in Patients with IBD
Teleconferences to Facilitate Multidisciplinary Care and Education in IBD
System Requirements for Delivery of Telemedicine Services
Legal, Regulatory, and Ethical Issues in the Use of Telemedicine
Future Directions in Telemedicine Applications for IBD.

Summary: This book provides an overview of key issues with regards to implementing telemedicine services as well as an in depth overview of telemedicine in pulmonary, critical care, and sleep medicine. Topics range from specific practices to program development. Telemedicine has experienced explosive growth in recent years and yet, implementing telemedicine solutions is complex with substantial regulatory, legal, financial, logistical, and intra-organization/intra-personal barriers that must be overcome. This book provides the necessary information and guidance to address those complex issues. This book is broadly divided into two parts 1) a primer on requisite steps before embarking on telemedicine service development and 2) specific applications and examples where telemedicine is successfully utilized to improve quality of care in pulmonary, critical care, and sleep medicine. The first part includes coverage of telemedicine and finance, regulatory and legal issues, and program development. The second part delves into specifics with information on ambulatory telemedicine programs, inpatient consultations, and tele-ICU programs. All chapters are written by interprofessional authors that are leaders in the field of telemedicine with extensive knowledge of diverse telemedicine programs and robust real-world experience on the topic. This is an ideal guide for telehealth program managers, and pulmonary, critical care, and sleep medicine professionals interested in improving their telehealth practice.

Contents:
SECTION I: Primer on Telemedicine Program Development
Overview and History of Telemedicine
Regulatory and Legal Issues
Telemedicine and Finance
Intra- versus Inter-organizational Issues in Telemedicine Program Development
Telehealth Services Framework
Technology and Data System Considerations
People Issues in Telemedicine
How Telemedicine Can Support High Quality Care
SECTION II: Application of Telemedicine in Pulmonary, Critical Care, and Sleep Medicine
Ambulatory Telemedicine Programs for Pulmonary Diseases
Emergency Department Based Consultations
Inpatient Consultations
Tele-ICU Programs.

Summary: This book provides an overview of the innovative concepts, methodologies and frameworks that will increase the feasibility of the existing telemedicine system. With the arrival of advanced technologies, telehealth has become a new subject, requiring a different understanding of IT devices and of their use, to fulfill health needs. Different topics are discussed - from the basics of TeleMedicine, to help readers understand the technology from ground up, to details about the infrastructure and communication technologies to offer deeper insights into the technology. The use of IoT and cloud services along with the use of blockchain technology in TeleMedicine are also discussed. Detailed information about the use of machine learning and computer vision techniques for the proper transmission of medical data - keeping in mind the bandwidth of the network - are provided. The book will be a readily accessible source of information for professionals working in the area of information technology as well as for the all those involved in the healthcare environment.

Contents:
Introduction and Fundamentals to Telemedicine
Infrastructure and systems of Tele-Medicine and Remote Health Monitoring
Legal perspective of Telemedicine - Policies, Legal and Regulatory Issues
Integration of IoT and Cloud with Telemedicine
Different technologies involved in Telemedicine
M-Health Applications
Machine Learning Techniques for TeleMedicine
The Role of Computer Vision in TeleMedicine
Communication technologies in telemedicine and M-Health and Ubiquitous healthcare
E- Health and Cyber Medicine
The Role of Blockchain in TeleMedicine
Security and Privacy issue in TeleMedicine: issues, solutions, and standards
The Role of TeleMedicine in COVID-19
TeleMedicine: A future of Healthcare Sector in India
Methodologies for Improving the Quality and Safety of Telehealth Systems
The role of computational bioinformatics in tele-based healthcare
Telemedicine in Children Health
Introducing Tele-Medicine into Surgical Care: Case Study
1Tele-Medicine in Oncology: Case Study 2 or other case studies in Tele-Medicine
A predictive model for disease diagnosis using machine-learning techniques
The network of TeleMedicine in Developing countries
Telemedicine: Present and Future applications.

Summary: Telemedicine and telehealth have consistently been shown to be effective for remote areas or limited-resource locations, regular medical and surgical practice, primary care, second opinion, extreme conditions, major crises, and disaster management. The aim of this book is to bring all aspects of telemedicine and e-health to the reader, in a simple, make-sense approach, in one tome. The book is structured in four parts with 29 chapters written by the best experts in the field from around the world, including clinicians, scientists, and administrators of telemedicine programs. Part I deals with basic principles of telemedicine and telepresence. Historical journeys of telemedicine and strategies, building sustainable telemedicine and telehealth programs in the United States and in the Balkans, as well as incorporation of telemedicine in the current ongoing pandemic COVID-19 are well described and are must read. Current technological developments, rules and regulations, legal and business aspects and consent are also addressed. Part II describes strategies for building sustainable telemedicine and telehealth programs. Telehealth patient portals and public-private partnership modes of technology, as well the role of international telemedicine and how to make it work, are valuable chapters of great significance. Part III describes outcomes-based evidence clinical applications of telemedicine in trauma, burns, intensive care, pediatric care, psychiatry, and stroke. Finally, one important chapter for the readers is the telemedicine for prison and jail population. The final part, Part IV depicts surgical telementoring and teleproctoring, a chapter written by 18 various surgical experts, a true gem for the readers. The book ends with promises and hurdles of telemedicine in austere conditions. Telemedicine, Telehealth and Telepresence serves as a valuable resource that focuses on providing patients care from a distance using store and forward technology to live actual performance of operations at a distance.

Contents:
First Trainees. The Golden Anniversary of the Early History of Telemedicine Education at the Massachusetts General Hospital and Harvard (1968-1970)
Initiate-Build-Operate-Transfer (IBOT) Strategy Twenty-years Later: Tales from the Balkans and Africa
Clinical Telemedicine Practice: From Ad Hoc Medicine to Modus Operandi
Incorporation of Telemedicine in Disaster Management: Beyond The Era of COVID-19 Pandemic
Telemedicine and Health Information Exchange: An Opportunity for Integration
Telehealth Dissemination and Implementation (D & I) Research: Analysis of the PCORI Telehealth-Related Research Portfolio
Standards and Guidelines in Telehealth: Creating a Compliance and Evidence-based Telehealth Practice
Federal and State Policies on Telehealth Reimbursement
Legal and Regulatory Implications of Telemedicine
Business Aspects of Telemedicine
Advancing Telehealth to Improve Access to Health in Rural America
Innovative Governance Model for a Sustainable State-Wide University-Based Telemedicine Program
Telehealth Patient Portal: Opportunities and Reality
Technology Enabled Remote Health Care in Public Private Partnership Mode: A Story From India
International and Global Telemedicine: Making it Work
Technological Advances Making Telemedicine and Telepresence Possible
Survey of the Direct-to-Hospital (DTH) Telemedicine and Telehealth Services Industry (2014-2018)
Telemedicine for Trauma and Emergency Care Management
Telemedicine for Burn Care: The Commonsense Telemedicine
Telemedicine for Intensive Care
Telehealth in Pediatric Care
Overview of Child Telebehavioral Interventions Using Real-Time Videoconferencing
Telemedicine for Psychiatry and Mental Health
Telecardiology
Telestroke and Teleneurology
Telemedicine for Prisons and Jail Population: A Solution to Increase Access to Care
Surgical Telementoring and Teleproctoring
The Promise and Hurdles of Telemedicine in Diabetes Foot Care Delivery
Telemedicine in Austere Conditions.

Summary: "This book describes in detail the potential role of ICT and electronic systems, together with the application of Web 2.0 technologies, in telepediatrics and child health. Rather than simply proposing engineering solutions that may soon become outdated, it is designed to address those real needs that telemedicine and developers are asked to meet. The orientation of the book is very much toward primary care, and both low- and high-income settings as well as extreme or complex scenarios are considered. The first two sections of the book describe different fields of application, such as the community, the hospital, and children with chronic illnesses or special needs, and examine technical issues. The use of telemedicine in delivery of care in extreme rural settings and developing countries is then discussed, with attention also to major emergencies and humanitarian crises. The closing chapters consider the role of modern technologies in the education of caregivers who work with children. Child health is a crucial issue in both industrialized and developing countries. Telemedicine for Children's Health will be an excellent guide to the potential value of telemedicine devices in reducing the burden for children and parents and in offering quick and concrete solutions in low-resource scenarios"--Provided by publisher.

Contents:
1. Perceived needs in paediatrics and children's health: overview and background
PART I. FIELDS OF APPLICATION. 2. The community
3. Telemedicine in acute settings and secondary care: the hospital
4. Management at home: the chronic child
5. Overtaking the distances: the child with special needs
PART II. TECHNICAL ISSUES. 6. Connectivity, devices and interfaces: worldwide interconnections
7. Technology and social web: social worldwide interactions
PART III. COMPLEX SCENARIOS AND SPECIAL SETTINGS. 8. Rural and extreme rural settings: reducing distances and managing extreme scenarios
9. Telepediatrics in developing countries: a better care for children in low-income settings
PART IV. e-LEARNING. 10. eLearning: distant learning for health professionals that works with children
11. Health education: teaching healthy lifestyles for a high quality of life
12. Conclusions.

Summary: As the healthcare landscape evolves towards value-based treatment models, healthcare providers will be forced to find ways to deliver healthcare in a cost-effective, resource mindful way that provides good care, all the while maintaining appropriate patient satisfaction. Telemedicine offers a way to achieve this goal, in both rural and urban settings and with a varied and diverse patient population - not to mention during global health emergencies, where in-person visits and consultations are not ideal. This book will serve as an introduction to telemedicine and digital health for the orthopedic and sports medicine provider. It will provide a general overview of telemedicine as well as specific suggestions and recommendations: where and how to get started, how to implement a telemedicine program, how to do research in telemedicine, and how to develop clinical guidelines and best practices for work in telemedicine. Specific chapters cover important nuts-and-bolts topics like regulation and licensing, billing and coding, and ethics and etiquette. Suggestions and considerations for provider-to-provider, direct-to-consumer, and school-based telemedicine service are likewise presented. Finally, insights into global telemedicine implementation and research are detailed. While describing specific applications to orthopedic and sports medicine practices, Telemedicine in Orthopedic Surgery and Sports Medicine will cater to any clinician - from the individual solo practitioner to the C-suite level executive - who has a vision for implementation of telemedicine across an entire health system.

Contents:
History and Evolution of Telemedicine
Telemedicine Regulation and Licensing
Telemedicine Billing and Coding
Legal Compliance in Telemedicine
Ethical Concerns in Telemedicine
Telemedicine Etiquette
Virtual Musculoskeletal Examination Using Telemedicine
Development and Implementation of Telemedicine in Practice
A Case Study in Telemedicine: Cerebral Palsy
Provider-to-Provider Telemedicine Consultation
Direct-to-Consumer Telemedicine
School-Based Telemedicine Services
Telemedicine in a Time of Crisis: The COVID-19 Experience
Global Telemedicine Health and Educational Initiatives
Telemedicine Research and Quality Assessment.

Summary: This text provides a concise, yet comprehensive overview of telemedicine in the ICU. The first part of the book reviews common issues faced by practitioners and hospital administrators in implementing and managing tele-ICU programs, including the merits of different staffing models, the challenges of building homegrown programs versus contracting for services, and the impact of state laws and payer policies on reimbursement for tele-ICU services. The second part of the book presents the current state of evidence for and against ICU telemedicine, based on clinical trials, before-and-after implementation studies, and observational data. The third part dives deeper into specific use cases for telemedicine in the ICU, including telestroke, pediatric and cardiac intensive care, and early treatment of declining patients with sepsis. Written by experts in the field, Telemedicine in the ICU is a practical guide for intensive care physicians and hospital administrators that provides all the information necessary in building and maintaining a successful tele-ICU program.

Contents:
Mobile Application for Medical Diagnosis
Emerging Paradigms in Transform-Based Medical Image Compression for Telemedicine Environment
Adopting m-Health in Clinical Practice: A Boon or a Bane?
Investigation of Telecardiology System to Detect Cardiac Abnormalities
Microaneurysms Detection for Early Diagnosis of Diabetic Retinopathy Using Shape and Steerable Gaussian Features
Telemetry System for Early Detection of Hyperbilirubinemia in Neonates
WBAN: Driving e-healthcare Beyond Telemedicine to Remote Health Monitoring: Architecture and Protocols
Remote Monitoring of Children With Chronic Illness Using Wearable Vest
A Predictive Model for Hypertension Diagnosis Using Machine Learning Techniques
From Telediagnosis to Teletreatment: The Role of Computational Biology and Bioinformatics in Tele-Based Healthcare
m-Health in Public Health Practice: A Constellation of Current Evidence
The Egyptian-African Telemedicine Network: The Treat and Teach Comprehensive Model
An Extended Views Based Big Data Model Toward Facilitating Electronic Health Record Analytics
Security and Privacy in Remote Healthcare: Issues, Solutions, and Standards
Virtual Clinic: A CDSS Assisted Telemedicine Framework.

Contents:
Introduction to telemental health and its use in resource-limited settings / Hussam Jefee-Bahloul
Telemental health modalities : videoconferencing, store-and-forward, web-based, and Mhealth / Jessica Becker
Telemental health in Africa / Sinclair Wynchank and Dora Wynchank
Telemental health in South Africa / Maurice Mars
Telemental health in the Middle East / Hussam Jefee-Bahloul and Zakaria Zayour
Telemental health in India / Rangaswamy Thara, Sujit John, and Kotteswara Rao
Telemental health services in Sri Lanka / Sisira Edirippulige and Rohana B. Marasinghe
Telemental health in Taiwan / Hsui-Hsin Tsai
Telemental health services for indigenous communities in Australia : a work in progress? / Sisira Edirippulige, Matthew Bambling, and Pablo Fernandez
Refugee telemental health in Denmark / Davor Mucic
Telemental health delivery for rural Native American populations in the United States / Shawn S. Sidhu, Chris Fore, Jay Shore, and Erin Tansey
Telemental health in Latin America and the Caribbean / Tammi-Marie Phillip
Cross-cultural telemental health / Niklas Skov Pape, Rasmus Christian Jørgensen, and Rune Weise Kofoed
Telemental health in post disaster settings / Eugene F. Augusterfer, Richard F. Mollica, and James Lavelle
Connecting the world : a way forward in global telemental health / Juan Rodriguez Guzman and Andres Barkil-Oteo.

Contents:
Teleneurology in the United States Veteran Health Administration
International Teleneurology
Military Telemedicine
Telemedicine Technology
Telestroke
Teleneurointensive Care Unit (TeleneurolICU)
Teleneurology and Neurointerventional Therapy for Acute Stroke
Teleneurosurgery
Hospital Teleneurology
Telemedicine and Parkinson Disease
Telebeuropatholgy
Tele-Epilepsy and Tele-Electroencephalography
The Emerging Relevance of Telemedicine in Sleep Medicine
Teledementia
The Emerging Role of Telemedicine in the Evaluation of Sports-related Concussion
Teleneurology in Contemporary Graduate Medical Education
Legal Considerations in the Use of Telemedicine in Neurology
Reimbursement in Teleneurology.

Contents:
Applications of Teleophthalmology: Systemic Diseases (Applications)
Ocular Diseases. Methods used in Teleophthalmology: Novel Imaging Devices
Information Technologies.

Summary: "Performing telephone triage requires the ability to make quick and effective decisions based on limited information. This rapid-access resource delivers more than 200 triage protocols for evaluating patients' symptoms over the telephone. Each symptom entry lists questions, grouped by urgency level, to determine whether the caller should seek emergency care immediately, seek medical care the same day, call back for appointment, or follow home care instructions. Detailed home care instructions are then provided. Simple, direct, and useful, this is the most comprehensive and user-friendly telephone triage book available"--Provided by publisher.

Summary: "Triage Protocols for Nurses is a resource to assist health care professionals make quick and effective decisions based on limited information using an algorithmic approach"-- Provided by publisher.

Summary: This book details the practice of telerheumatology. Telemedicine is defined as the delivery of healthcare and the exchange of healthcare information across distances. Following, telerheumatology is the delivery of rheumatology care through telemedicine. There exists an increasing demand from patients, caregivers, and healthcare systems for access to academic specialists through telemedicine. This has been the case for the past several years and the demand has only increased with the ongoing COVID-19 pandemic. There is currently a lack of rheumatologists in rural areas and that is expected to spread to a general lack by 2025. Telerheumatology offers an excellent and timely solution to fill these gaps and provide care Telerheumatology care has been shown to be feasible and quite effective. The current COVID-19 pandemic has thrust the concept of telemedicine into the spotlight. However, not all telerheumatology care is the same and there exists many nuances and differences when examining telerheumatology care across the United States and the world. After comprehensively reviewing the origins of telerheumatology, this work defines in detail the current practice of telerheumatology, along with the specific impact of the COVID-19 pandemic and all applications of telerheumatology. Expert authors also provide a detailed roadmap for providers to initiate, sustain, and grow a telerheumatology program. The book concludes by covering future directions of telerheumatology, including areas for expansion, improvement, and innovation. After reading this work, the editor and all the contributing authors hope that it will inspire, provoke thought and discussion, and lead to increased adaptation of providing telerheumatology care by rheumatologists and rheumatology providers.

Contents:
INTRODUCTION
Telerheumatology: A Historical Perspective
Overview of Synchronous and Asynchronous Modalities
The Role of eConsults
Equipment, Technology, and Support
Telepresenter Training and the Virtual Physical Exam
Documentation, Licensing, and HIPAA Compliance
Legal and Regulatory Primer for the Practice of Telemedicine in the United States
Best Practices for Billing and Coding
Determining the Value of Telerheumatology
MEASURING DISEASE ACTIVITY AND FUNCTIONAL CAPACITY IN TELERHEUMATOLOGY
Rheumatology Telementoring: The ECHO Model
Rural Health Care and Telerheumatology
TELERHEUMATOLOGY AND THE CHRONIC CARE MODEL
Telerheumatology and the Department of Veterans Affairs
Review of the Evidence for Telerheumatology
Satisfaction with Telerheumatology Care: Patient and Clinician Perspectives
Telerheumatology During the COVID-19 Pandemic and Beyond
Private Practice and Telerheumatology
Pediatric Telerheumatology
Telerheumatology With Learners
PATIENT PERSPECTIVES AND NARRATIVES
Future Directions and Innovation.

Contents:
The history of telocyte discovery and understanding / Jian Wang, Meiling Jin, Wen-huan Ma, Zhitu Zhu, Xiangdong Wang
Decoding telocytes / Junjie Xiao, Yihua Bei
Extracellular microvesicles (EXMVs) in cell to cell communication: a role of telocytes / Mariusz Z. Ratajczak, Daniel Ratajczak, Daniel Pedziwiatr
Telocytes in chronic inflammatory and fibrotic diseases / Lidia Ibba-Manneschi, Irene Rosa, Mirko Manetti
Telocytes: new players in gallstone disease / Artur Pasternak, Krzysztof Gil, Andrzej Matyja
Features of telocytes in agricultural animals / Ping Yang, Nisar Ahmed, Shakeeb Ullah, Qiusheng Chen, Yonghua Zheng
The telocyte subtypes / Maria-Giuliana Vannucchi, Maria-Simonetta Faussone-Pellegrini
Telocytes in cardiac tissue architecture and development / Daniele Bani
The potential role of telocytes for tissue engineering and regenerative medicine / Raymund E. Horch, Annika Weigand, Justus P. Beier, Andreas Arkudas, Anja M. Boos
Presence of telocytes in a non-innervated organ: the placenta / Cleofina Bosco, Eugenia Díaz
Telocytes in exocrine glands stroma / Mihnea Ioan Nicolescu
Telocyte behaviour during inflammation, repair and tumour stroma formation / L. Díaz-Flores, R. Gutiérrez, M. González-Gómez, L. Díaz-Flores Jr, F. Valladares [and others]
Paracrine signaling in the prostatic stroma: a novel role for the telocytes revealed in rodents' ventral prostate / Bruno D. A. Sanches, Lara S. Corradi, Patricia S. L. Vilamaior, Sebastião R. Taboga
Primary extragastrointestinal stromal tumours in the hepatobiliary tree and telocytes / Somanath Padhi, Hemanta Kumar Nayak
Cardiac telocytes in regeneration of myocardium after myocardial infarction / Liao Zhaofu, Cai Dongqing
Myocardial telocytes: a new player in electric circuitry of the heart / Winston Shim
Roles of telocytes in the development of angiogenesis / Yonghua Zheng, Xiangdong Wang,
Telocytes in inflammatory gynaecologic diseases and infertility / Xiao-Jun Yang
Electrophysiological features of telocytes / Daniel Dumitru Banciu, Adela Banciu, Beatrice Mihaela Radu
The cutaneous telocytes / Catalin G. Manole, Olga Simionescu,
The third dimension of telocytes revealed by fib-sem tomography / Dragos Cretoiu
Immunohistochemistry of telocytes in the uterus and fallopian tubes / Sanda Maria Cretoiu
A tale of two cells: telocyte and stem cell unique relationship / Zeinab M. El Maadawi
Vascular telocytes / Hongqi Zhang
Juxtacerebral tissue regeneration potential: telocytes contribution / Laura Cristina Ceafalan, Bogdan Ovidiu Popescu
Telocytes of fascial structures / Joanna Dawidowicz, Natalia Matysiak, Sylwia Szotek, Krzysztof Maksymowicz
Hepatic telocytes / Yingying Zhao, Xiaoyu Chen, Fei Wang, Changqing Yang.

Contents:
Temporal bone dissection laboratory
Anatomy of the temporal bone
Transmastoid approaches
Translabyrinthine approaches
Facial nerve decompression
Middle cranial fossa approaches
Retrosigmoid retrolabyrinthine approach
Transotic approach
Modified transcochlear approach (type A)
Infratemporal fossa approaches
Bibliography.

Summary: This volume comprehensively reviews the current literature on temporal bone cancer and the multidisciplinary approaches used to managing these rare tumors. The text will review important medical issues as they specifically relate to temporal bone cancer such as advanced imaging, pathologic classification, skull base surgery, plastic reconstructive surgery, and advances in osseointegrated implants for hearing restoration. Additional chapters are dedicated to the evaluation and management, diagnostic radiology, surgical planning and techniques, radiotherapy, chemotherapy, and rehabilitation. An emphasis is placed on the multidisciplinary approach required for the optimal care of these rare tumors. Written by leaders in the field, Temporal Bone Cancer will be an invaluable resource for residents and fellows in Otolaryngology, Neurosurgery and Neurotology, and clinicians with interest in the primary tumors of the temporal bone. .

Summary: This book, featuring more than 180 high spatial resolution images obtained with state-of-the-art MDCT and MRI scanners, depicts in superb detail the anatomy of the temporal bone, recognized to be one of the most complex anatomic areas. In order to facilitate identification of individual anatomic structures, the images are presented in the same way in which they emanate from contemporary imaging modalities, namely as consecutive submillimeter sections in standardized slice orientations, with all anatomic landmarks labeled. While various previous publications have addressed the topic of temporal bone anatomy, none has presented complete isotropic submillimeter 3D volume datasets of MDCT or MRI examinations. The Temporal Bone MDCT and MRI Anatomy offers radiologists, head and neck surgeons, neurosurgeons, and anatomists a comprehensive guide to temporal bone sectional anatomy that resembles as closely as possible the way in which it is now routinely reviewed, i.e., on the screens of diagnostic workstations or picture archiving and communication systems (PACS).

Contents:
Preface
Temporal bone imaging techniques
MDCT and MRI
Axial CT images
Coronal CT images
Oblique coronal (Stenvers) CT images
Axial MR images
Alphabetical index.

Contents:
Introduction to temporal bone dissection / Howard W. Francis and John Niparko
Anatomy of the temporal bone / Howard W. Francis and John Niparko
Mastoidectomy / Howard W. Francis and John Niparko
Endoscopic middle ear dissection / Alejandro Rivas
Labyrinthectomy / Howard W. Francis and John Niparko
Translabyrinthine exposure of the internal auditory canal / Howard W. Francis and John Niparko
Middle cranial fossa approach to the internal auditory canal / Rick Friedman
Infratemporal dissection / Rick Friedman
Skill transfer to the operating room including management of complications / Melville da Cruz
Promoting competence in temporal bone surgical dissection / Melville da Cruz, Nasir I. Bhatti, John Niparko, and Howard w. Francis.

Summary: This book provides a complete overview of imaging of normal and diseased temporal bone. After description of indications for imaging and the cross-sectional imaging anatomy of the area, subsequent chapters address the various diseases and conditions that affect the temporal bone and are likely to be encountered regularly in clinical practice. The classic imaging methods are described and discussed in detail, and individual chapters are included on newer techniques such as functional imaging and diffusion-weighted imaging. There is also a strong focus on postoperative imaging. Throughout, imaging findings are documented with the aid of numerous informative, high-quality illustrations. Temporal Bone Imaging, with its straightforward structure based essentially on topography, will prove of immense value in daily practice.

Contents:
Indications for temporal bone imaging: the clinician's approach
Temporal bone imaging techniques
Cross-sectional imaging anatomy of the temporal bone
External ear imaging
Acute otomastoiditis and its complications
Chronic otomastoiditis without cholesteatoma
Imaging of cholesteatoma
Otosclerosis
Temporal bone trauma
Temporal bone tumours
Congenital malformations of the temporal bone
Imaging of cerebellopontine angle and internal auditory canal lesions
Inner ear pathology
Imaging of cochlear implants
Petrous apex lesions
Pathology of the facial nerve
Imaging of the jugular foramen
Vascular temporal bone lesions
Post-operative temporal bone imaging
MultiPlanar reformation in CT of the temporal bone.

Summary: This book presents standard imaging techniques, basic anatomy and an approach to common pathology encountered in temporal bone imaging. Intended as a survival guide for residents and general radiologists, it covers all topics comprehensively, and provides intuitive point-by-point summaries, similar to those of popular radiology reference sites, for easy comprehension at a glance. The book also offers guidance on the pertinent points that need to be included in a report and how to answer basic questions that are likely to be asked by the referring clinician or supervising radiologist. This book will be a valuable resource for general radiologists, radiology residents, ENT residents, otology surgeons and anyone involved in the occasional temporal bone study.

Contents:
Part I. Basic Anatomy and Approach to Common Symptoms; Making Sense of History
Basic Temporal Bone Imaging Anatomy; External, Middle and Inner Ear
Temporal Bone Imaging Techniques; Computer Tomography, Cone Beam CT and Magnetic Resonance Imaging
Imaging Approach to Conductive Hearing Loss
Imaging Approach to Sensorineural Hearing Loss
Imaging Approach to Tinnitus
Imaging Approach to Otorrhea
Imaging Approach to Otalgia
Common Otoscopic Signs, Imaging of Common Surgeries and Implants
Part II. Imaging of External Ear Pathology
Radiological Features of Otitis Externa
Imaging of External Ear Masses; Cholesteatoma and Tumours
Imaging of External Ear Malformations, Canal Stenosis and Exostosis
Part III. Imaging of Middle Ear and Mastoid Air Cells Pathology
Imaging of Otomastoiditis, Acute and Chronic
Radiological Features of Acquired and Congenital Cholesteatoma
Radiological Features of Oval Window Atresia
Part IV. Imaging of Inner Ear Pathology
Imaging of Inner Ear Malformations and Vestibular Aqueduct Syndrome
Radiological Features of Otosclerosis
Other Causes of Inner Ear Hearing Loss: Meniere's Disease, Labyrinthitis & Semicircular Canal Dehiscence
Part V. Imaging of Temporal Bone Trauma, Petrous Apex, Cerebello-Pontine Angles, Jugular Foramen & Facial Nerve
Imaging of Temporal Bone Trauma
Imaging of the Petrous Apex, Cerebello-Pontine Angles & Jugular Foramen
Imaging of the Facial Nerve: Approach and Pathology.

Summary: "A valuable resource on how to diagnose and treat temporomandibular disorders (TMD) The newly and thoroughly revised 2nd Edition of Temporomandibular Disorders: A Problem-Based Approach delivers a systematic and logical approach to diagnosing and treating temporomandibular disorders. Using a case-based approach to assist readers with understanding and retention, the book discusses the practical realities of managing patients and promoting effective treatment of temporomandibular disorders. Containing full colour clinical images and diagrams throughout, the chapters include practical guides on how to make splints and samples of patient information sheets which can be used as templates. Readers will get access to topics such as: The clinical aspects of anatomy, function, pathology, and classification; Differential diagnosis of temporomandibular joint problems; Clicking joint problems and the use of preliminary investigation in disc displacement; Temporomandibular joint locking diagnosis and treatment, including final treatment plans; Facial pain examinations, differential diagnosis, and questions to ask patients regarding pain in general; Headaches, worn teeth, dislocated jaws, and more issues that arise in the treatment of temporomandibular joint problems"-- Provided by publisher.

Contents:
About the book
Clinical aspects of anatomy, function, pathology and classification
Articulatory system examination
I've got "TMJ"
I've got a clicking joint
I've got a locking joint
I've got a grating joint
You've changed my bite
I've got pain in my face
I've got a dislocated jaw
My teeth are worn
I've got a headache
I've got whiplash
What's of use to me in practice?
You and the lawyer
The referral letter
How to make a splint
Current knowledge of aetiology and management of bruxism
Splint therapy for the management of TMD patients : an evidence-based discussion
Patient information.

Summary: This book on the local and systemic manifestations and correlates of temporomandibular joint disorders (TMDs) encompasses the two intertwined facets of translational science -- translational research and translational effectiveness -- as they relate specifically to TMDs. The first part of the book, on recent translational research, focuses on topics such as the neuroanatomy and neurophysiology of the trigeminal nerve and trigeminal network system, the manifestations of neuroinflammation in TMDs, and the molecular mechanisms underlying TMDs. The second part discusses the clinical effectiveness of treatment approaches from the perspective of evidence-based dentistry, with careful attention to the critical relationships between dental malocclusions, the signs and symptoms of TMDs, and airway/breathing disorders. Interventions to correct for malocclusal conditions that lead to TMDs are examined, with explanation of the ways in which they can ameliorate a variety of local and systemic symptoms. This will be an excellent reference book for established practitioners, residents, interns, and students as well as a powerful cutting-edge document for researchers in the field. .

Summary: This book is designed to provide a crisp and necessary information for all the under-graduate and post-graduate medical students, Oral and Maxillofacial Surgeons, ENT Surgeons, General Surgeons, General Dentists and other health care workers who deal with TMDs in their practise. It includes contributions from eminent surgeons across the world who treat TMJ disorders and diseases using various conventional to modern state of the art techniques. Temporomandibular joint disorders (TMDs) are familiar yet difficult to diagnose in routine practice due to the complexity of the joint and its surrounding structures. The symptoms usually associated with TMDs present with pain, joint sounds such as click or crepitus, difficulty during mastication, reduced mouth opening are some of the many presentations. Definite diagnosis of the TMDs can be challenging as the patients present with varying symptoms. These disorders of the joint can vary from a simple disc displacement to complex pathologies. Management of the TMDs can be tricky and hence need a thorough evaluation of the joint and surrounding structures. There has been a tremendous leap in managing these disorders from simple conservative management to several advanced surgeries to salvage the joint. This compilation highlights all the relevant details regarding TMDs and its management which will offer utmost details to practising surgeons who often deal with TMDs. This book will be a delight to read for all the clinicians and surgeons who are interested in treating the small yet complex jaw joint in the facial region.

Contents:
Part I Introduction
Introduction
TMJ Biomechanics
TMJ TJR Biomaterials Considerations
History of TMJ TJR (Mercuri)
Part II TMJ TJR Devices
Stock TMJ TJR Devices
Custom TMJ TJR Devices
Part III Advanced TMJ TJR Techniques
TMJ TJR in combination with orthognathic procedures
Mandibular replacement utilizing TMJ TJR devices
Part IV Complications
TMJ TJR surgical Complications, prevention and management
Material Hypersensitivity
Tribocorrosion and TMJ TJR devices
Management of failing and failed TMJ TJR Devices
Part V Future Considerations
Bioengineered Tissue TMJ TJR.

Summary: This comprehensive office guide will provide up-to-date diagnostic and management information for various tendinopathies seen in the clinic. Opening chapters discuss the basic science of tendons: physiology, pathophysiology and biomechanics, including mechano-transduction. Subsequent chapters focus anatomically on both the upper and lower extremities, from the rotator cuff to the wrist and hand, and from the groin and gluteus down to the foot and ankle. Each of these chapters follows a concise, easy-to-use format, consisting of an introduction followed by clinical presentation, physical examination, imaging and radiographic grading, and treatment strategies both surgical and non-surgical, including indications for surgical referral. The concluding chapters present emerging mechanical, orthobiologic and chemical in-office procedures as well as emerging operative techniques. Practical and user-friendly, Tendinopathy will be an excellent resource for sports medicine specialists, orthopedic surgeons, physical therapy and rehabilitation specialists, and any other clinicians treating these common athletic injuries.

Contents:
Biological and Biomechanical Adaptation of Young and Aging Tendons to Exercise
The Pathogenic Mechanisms of Tendinopathy
Rotator Cuff Tendon
Biceps Tendon
Common Extensor Tendon/Common Flexor Tendon
Tendons in Wrist and Hand
Rectus Abdominis and Hip Adductor Tendon
Proximal Hamstring Tendinopathy
Lateral Gluteal Tendinopathy
Quadriceps Tendon
Patellar Tendinopathy
Distal Hamstring, Pes Anserine, Popliteal Tendinopathy
Peroneal Tendinopathy
Anterior/Dorsal Ankle Tendons
Medial Ankle/Plantar Foot Tendinopathy
Achilles Tendon
Plantar Fascia
Office-Based Mechanical Procedures for Tendons
Office-Based Orthobiologic Procedures for Tendons
Emerging In-Office Procedures: Chemical Ablation, Dextrose Hyperosmolar Injections
Emerging Operative Procedures for Tendons.

Summary: Injuries of the foot and ankle can be debilitating and lead to chronic instabilities that can impede the daily activities of patients. As a result, it requires a solid understanding of foot and ankle anatomy and pathology in order to diagnosis these types of injuries and establish a clear treatment regimen for the patient to be functional and prevent long-term complications. For the foot and ankle specialist, the understanding of the injury patterns and treatment algorithms continues to evolve with the addition of new information on non-surgical and surgical techniques that are continuing to be introduced to the medical community. However, it is important to determine how the latest developments and treatment advances are disseminated through an evidence-based approach, to allow for proper evaluation of their usefulness as well as how to properly initiate and perform these treatments during patient care. To that end, this book provides a comprehensive overview of the diagnosis and management of muscle, tendon and ligament injuries of the foot and ankle. Opening with a review of diagnostic and imaging procedures, focused, concise chapters then describe the current evaluation and management strategies for a wide variety of soft tissue conditions, including turf toe, Lisfranc injuries, acute and chronic later ankle injuries, subtalar joint injuries, peroneal tendon injuries, and Achilles tendon injuries, among others. Each chapter brings together and reviews the latest literature on the topic, offering evidence-based guidelines for foot and ankle specialists, orthopedic surgeons and podiatrists as well as residents, fellows and all staff involved in the treatment of these injuries and conditions.

Contents:
Imaging of Soft tissue Injuries of the Foot and Ankle
Turf Toe Injuries
Plantar Plate Injuries
Lisfranc Injuries
Anterior Tibial Tendon Injuries
Peroneal Tendon Injuries
Posterior Tibial Tendon Injuries
Plantar Fascia Injuries
Medial Deltoid Ligament Injuries
Lateral Ankle Ligament Injuries
Syndesmotic Injuries
Achilles Tendon Injuries.

Contents:
Section I: Etiology
Definition, Causes and Epidemiology
Tennis Elbow in Athletes: More Than Just Tennis?
Golfer's Elbow: Treatment Distinctions
Section II: Conservative Treatment
Evidence for No Treatment and Self-limited Treatment
Medical Management: The Role of NSAIDS and Topical
Therapy
Splints
Steroid Injections
Blood and PRP Injections
Other Treatments: Prolotherapy, Acupuncture, ESWL
Section III: Surgery
Open Surgical Treatment
Arthroscopic Treatment
Denervation
Percutaneous Release
Outcomes of Treatment and Return to Play: The Evidence
Complications of Surgical Treatment and Salvage Procedures for Failed Surgery.

Summary: This book will serve as a key resource for all clinicians working in orthopedics, sports medicine, and rehabilitation for the sport of tennis. It provides clinically useful information on evaluation and treatment of the tennis player, covering the entire body and both general medical and orthopedic musculoskeletal topics. Individual sections focus on tennis-related injuries to the shoulder, the elbow, wrist, and hand, the lower extremities, and the core/spine, explaining treatment and rehabilitation approaches in detail. Furthermore, sufficient sport science information is presented to provide the clinical reader with extensive knowledge of tennis biomechanics and the physiological aspects of training and rehabilitation. Medical issues in tennis players, such as nutrition and hydration, are also discussed, and a closing section focuses on other key topics, including movement dysfunction, periodization, core training, and strength and conditioning specifics. The expansive list of worldwide contributors and experts coupled with the comprehensive and far-reaching chapter provision make this the highest-level tennis medicine book ever published.

Contents:
Section I
Biomechanics & Pathophysiology: 1Biomechanics of the Tennis Serve
2 Biomechanics of Groundstrokes and volleys
3 Epidemiology of Tennis
4 Pathophysiology of Tennis Injuries: The Kinetic Chain
5 Biomechanics & Physical Properties of the Tennis Racquet, Strings, Ball Contact and Shoe/Court Interface: Implications for Injury in Tennis Players
Section II
Player Evaluation: 6Physical Evaluation of the Shoulder and Elbow in Tennis Players
7 Physical Evaluation of the Hip
8 Physical Evaluation of the Spine
9 Imaging of the Shoulder and Hip
10 Musculoskeletal Screening for the Elite and Developing Tennis Player (The USTA HPP and ATP PIPS)
11 The Pre-Participation Physical – The WTA Experience & Findings
12 Fitness Testing / Screening in Elite Tennis Players
Section III
Shoulder Injuries: 13 Rotator Cuff Injuries (include Full Thickness and Partial thickness)
14 Labral Injuries and Posterior Impingement in Tennis Players
15 Scapulothoracic Evaluation & Treatment in Tennis Players
16 Rehabilitation of the Shoulder in Tennis Players
17 Osteo Arthritis and the Senior Tennis Player
Section IV- Elbow Wrist & Hand Injuries: 18 Pathophysiology of Tendon Injury: Implications for Tennis Elbow
19 Humeral Epicondylitis in Elite Tennis Players: (Include injections & Surgical Management) & Indications for Elbow Arthroscopy
20 Rehabilitation of the Elbow
21 Minimally invasive treatment of wrist and hand lesions in tennis players
22 Pathophysiology of wrist and hand injuries in tennis players: tendons, ligaments and TFCC lesions
23 Wrist and Hand Rehabilitation
Section V
Lower Extremity Injuries
24 Principles of Hip Arthroscopy in Elite Tennis Players
25 Treatment of Labral Injuries & FAI in Tennis Players
26
Rehabilitation of Hip Injuries
27 Thigh and Knee Injuries
28 Pathophysiology and Treatment of Patellar Tendonitis
29 Rehabilitation of Knee Injuries
30 Foot and Ankle Injuries in Tennis players: Rehabilitation of Foot and Ankle Injuries including Orthotic Management for Prevention and Treatment of Lower Extremity Injuries in Tennis Players
31 Acute Management of Foot & Ankle Injuries (Taping and Padding)
Section VI
Spinal Injury: 32 Injuries to the Spine in Elite Tennis Players & Spondylolisthesis in Developing Tennis Players: Special Considerations and Research Findings
33 Spinal Rehabilitation
34 Core Stability in Tennis Players
Section VII
Medical Issues: 35 Key Medical Issues for Tennis Players
36 Sports Nutrition for Tennis Players
37 Heat Illness and Hydration for Tennis Players
38 Special chapter on Tournament Physician Issues at an event
39 Dermatologic Considerations in Elite Tennis Players
Section VIII
Special Topics: 40 Strength and Conditioning in Elite and Developmental Tennis Players
41 Movement Dysfunction Syndromes
42 Strength & Conditioning of the Hips and Core
43 The Role of Scheduling &Periodization in Elite Tennis Players: (chapter on management and planning of player scheduling/off-season /number of matches needed for development etc).

Summary: This revised new edition containing numerous new and heavily updated chapters provides readers with the essential information needed to understand the central topics of terminology in healthcare, the understanding of which is an asset to be leveraged in care and research. Twenty-five years ago the notion that terminology should be concept-based was all but unknown in healthcare; now almost all important terminologies are at least partly concept-based. With no general model of what a terminology was or should be, there were no tools to support terminology development and maintenance. Steady progress since then has improved both terminology content and the technology and processes used to sustain that content. This new edition uses real world examples from the health sector to delineate the principal issues and solutions for the field of data representation. It includes a history of terminologies and in particular their use in healthcare, including inter-enterprise clinical and research data aggregation. Terminology, Ontology and their Implementations covers the basis, authoring and use of ontologies and reference terminologies including the formalisms needed to use them safely. The editor and his team of carefully chosen contributors exhaustively reviews the field of concept-based indexing and provides readers with an understanding of natural language processing and its application to health terminologies. The book discusses terminology services and the architecture for terminological servers and consequently serves as the basis for study for all students of health informatics.

Contents:
Intro
Introduction
Contents
Chapter 1: History of Health Terminology
References
Chapter 2: Knowledge Representation and Logical Basis of Ontology
Mapping Free Text Data into a Structured and Logical Form
Symbolic Logic
Glossary
Identity of Compositional Expressions Can Be Expressed in the Following Fashion
Object Orientation
What Is UML?
UML Views
UML Diagrams
Class Diagram
Class Attributes
Class Operations
Visibility
Object Diagram
Use Case Diagram
Sequence Diagram
Collaboration Diagram
Class Model for Database Design Mapping Tables to the Classes
Mapping Columns to the Attributes
Views
Keys
Constraints
Object Constraint Language (OCL)
Invariant
Pre- and Postconditions
OCL Types
Collection Operations
Unified Modeling Language
What Is a Model?
UML Model: Foundation Core
UML Metamodel: Model Management
UML Metamodel: Common Behaviors
UML Metamodel: Extension Mechanisms
Web Ontology Language (OWL)
Ontology Definitions
What Is the Semantic Web?
Use of Ontologies in Health Informatics
Resource Description Framework (RDF)
Web Ontology Language (OWL) Basic OWL Elements
Class Identifiers
Enumeration
Property Restrictions
Value Restrictions
Cardinality Constraints
Property Constraints
OWL Individuals
Properties
Data Types
OWL Language Elements
OWL Abstract Syntax
Class Axioms
Property Axioms
Restrictions
Purpose of Axioms
OWL Language and Its Formal Logic
Membership in OWL Classes
Characteristics of the Members of OWL Classes
OWL Properties with If and Only If (Iff) Characterizations
OWL Properties with If Characterizations
Reasoning in OWL
SPARQL Query Language Writing a Simple Query
Common Logic
Features of Common Logic Include
Conclusion
References
Chapter 3: Theoretical Foundations of Terminology
Types of Terminologies
Lists
Definitions
Systematic Definitions
Formal Definitions
Hierarchies Within Terminologies
Best Practices in Terminology Design and Evaluation
Terms and Definitions
General Principles
The Basics
Concept Orientation
Non-redundancy
Non-ambiguity
Non-vagueness
Internal Consistency
Purpose and Scope of a Terminology
Coverage
Comprehensiveness
Mapping Systematic Definitions
Formal Definitions
Explicitness of Relations
Reference Terminologies
Atomic Reference Terminologies
Colloquial Terminologies
Structure of the Terminology Model
Terminology Structures
Compositional Terminologies
Compositionality
Atomic Concept
Composite Concept
Pre-coordinated Concept
Post-coordinated Concept
Types of Atomic and Pre-coordinated Concepts
Kernel Concept
Modifiers and Qualifiers: Terms Which Refine the Meaning of a Kernel Concept
Normalization of Content
Normalization of Semantics
Multiple Hierarchies

Summary: This set of teaching notes provides extensive guidance for educators related to its sister title and contains numerous tools and questions to help educators provide didactics and evaluation of students in this essential area of biomedical informatics. This is needed to understand the central topics of ontology, terminology and terminological systems in healthcare. Twenty-five years ago the notion that ontology would be essential to knowledge representation in healthcare was all but unknown. Almost all important terminologies and many ontologies are now in wide use and are growing in importance. With no general model of what a ontology and terminology should be, there are an increasing number of tools to support ontology / terminology development, implementation and maintenance. Steady progress since then has improved both ontology / terminology content and the technology and processes used to sustain that content. Terminology, Ontology and their Implementations: Teaching Guide and Notes provides extensive teaching materials to accompany Terminology, Ontology and their Implementations . It provides further definition of the topic and explains the use of reference terminologies needed to use them safely. It contains questions and explanations from each section of the textbook, making it easier to use the text in teaching Health Informatics students. The authors also provide supplementary information about the questions, their relevance and their relation to other concepts. This book augments Terminology, Ontology and their Implementations by assisting the understanding of terminology services and the architecture for terminological servers, and consequently serves as an essential tool for educators in their efforts to teach students in their study of health informatics.

Contents:
Introduction
History of Terminology and Ontology
Knowledge Representation and the Logical Basis of Ontology
Theoretical Foundations of Terminology
Terminology Requirements and Standards Development
Terminology Design
Maintenance
Quality Control
Realism Based Ontology
What is an ontology?
Ontology vs. terminology
Ontology vs. taxonomy
Ontologies and databases
Ontology and the Semantic Web
Ontology in biomedical informatics
Bad ontologies
The concept orientation
Why ontologies so often fail
Recipes for success
Examples of successful ontologies and of how they are being used
The place of Referent Tracking in Biomedical Informatics
Introduction: what is Referent Tracking (RT)? How does it relate to ontology? What does it aim to achieve? Why does it matter?
Basic principles: how RT is build on top of three important distinctions made in realism-based ontology: particulars types, continuants occurrents, referents references
Syntax and semantics of RT-expressions
RT as a development tool for ontologies
Using RT to detect and prevent flaws in scientific research and ambiguities and inconsistencies in reports and papers
RT as a solution for semantic interoperability
Werner Ceusters
Bioontology in Service of Translational Science
Introduction to Bioontologies and the OBO Foundry
The Gene Ontology
Overview of GO Content and Structure
GO annotation
Term Enrichment/Pathway Analysis
Success Stories
Challenges
Bioontologies and Data Annotation Systems
ImmPort/HIPC
Kidney Precision Medicine Project
GEO and Array Express
Disease and Phenotype Annotation for Translational Studies
Use of Ontologies at Mouse Genome Informatics
HPO and the Monarch Project
Compositionality: An Implementation Guide
Interface Terminologies
SNOMED CT
RxNorm and NDF-RT and ATC codes
LOINC
SOLOR
ICD
CPT
HCC Codes / Risk Adjustment and MACRA / MIPS
DRGs
NCI EVS
Nursing Terminologies
RED / MED
UMLS Metathesauras and knowledge sources
Terminological Systems
HL7 FHIR and APIs
Lessons Learned and Suggested Research Agenda
The future of coding and coding systems
Conclusion.

Summary: "From injuries caused by lead poisoning to the devastating effects of atmospheric pollution, infectious disease, and industrial waste, Americans of color are harmed by environmental hazards in staggeringly disproportionate numbers. This systemic onslaught of toxic exposure and institutional negligence causes irreparable physical harm to millions of people across the country--cutting lives tragically short and needlessly burdening our health care system. But these deadly environments create another insidious and often overlooked consequence: robbing communities of color, and America as a whole, of intellectual power. The 1994 publication of The Bell Curve and its controversial thesis catapulted the topic of genetic racial differences in IQ to the forefront of a renewed and heated debate. Now, in A Terrible Thing to Waste, award-winning science writer Harriet A. Washington adds her incisive analysis to the fray, arguing that IQ is a biased and flawed metric, but that it is useful for tracking cognitive damage. She takes apart the spurious notion of intelligence as an inherited trait, using copious data that instead point to a different cause of the reported African American-white IQ gap: environmental racism--a confluence of racism and other institutional factors that relegate marginalized communities to living and working near sites of toxic waste, pollution, and insufficient sanitation services. She investigates heavy metals, neurotoxins, deficient prenatal care, bad nutrition, and even pathogens as chief agents influencing intelligence to explain why communities of color are disproportionately affected--and what can be done to remedy this devastating problem"--Dust jacket.

Contents:
Introduction: IQ matters
Part I: Color-coded intelligence? The prism of race : how politics shroud the truth about our nation's IQ
Part II: The brain thieves. The lead age : heavy metals, low IQs
Poisoned world : the racial gradient of environmental neurotoxins
Prenatal policies : protecting the developing brain
Bugs in the system : how microbes sap U.S. intelligence
Part III: Mission possible : how to bolster the nation's IQ. Taking the cure : what can you do, now?
A wonderful thing to save : how communities can unite to preserve brainpower
Glossary
List of known chemical brain drainers.

Summary: "This text should serve to highlight test taking weaknesses and the skills or strategies that may be useful to improve those weaknesses. Such weaknesses include a poor approach to the exam, difficulty reasoning through concepts, difficulty categorizing information, and anchoring. These weaknesses are the focus of this text. There are also skills and strategies that are important to refine as we become expert test-takers, such as time management, approach to reviewing labs, dealing with under confidence, and re-viewing answer choices at the end of an exam. You will be lead through general and specific test taking skills and weaknesses with practice questions so that upon completion of this text, you will hopefully be fully equipped to achieve the score (and career) of your dreams"--Publisher's description.

Contents:
Skills & pitfalls
The 5-step approach
Weakness: reasoning
Weakness: categorizing information & illness scripts
Weakness: anchoring
Additional practice questions.

Contents:
1. Biological background of testicular autoimmunity
2. Microcircumstance for induction and prevention of testicular autoimmunity
3. Human testicular autoimmunity as a result of breakdown of testicular immune privilege
4. Testicular autoimmunity by immunization with testicular antigens alone in experimental animals
5. Testicular autoimmunity by the systemic treatment with immuno-potentiating agents in experimental animals
6. Testicular autoimmunity by local injury of the testis in experimental animals
7. Testicular autoimmunity by alteration of the immune system in experimental animals
8. The future directions of testicular autoimmunity investigation
Erratum.

Summary: Text and Atlas of Wound Diagnosis and Treatment delivers outstanding visual guidance and clear, step-by-step instruction on caring for patients with wounds. Packed with hundreds of full-color illustrations and clear, concise text, this unique learning tool provides thorough easy-to-understand coverage of evidence-based concepts of would treatment.

Contents:
Integumentary basics
Wound diagnosis
Wound bed preparation
Adjunctive therapies

Summary: "Wound care is covered in the 2nd or 3rd year of Physical Therapy school and is a part of every school's curriculum. Examples of interventions that are provided by physical therapists inlcude sharp debridement, dressing selection and application, compression for both chronic venous insufficiency and lymphedema, electrical stimulation, total contact casets and orthotic fabrication for neuropathic wounds, ultrosound, pulsed lavage with suction and negative pressure wound therapy. In addition, many worund therapists are included in the diagnostic provecess, especially determining the functional and gait impairments that may contribute to wound formation"-- Provided by publisher.

Contents:
-- PART ONE: Integumentary Basics
Chapter 1: Anatomy and Physiology of the Integumentary System
Chapter 2: Healing Response in Acute and Chronic Wounds
Chapter 3: Examination and Evaluation of the Patient with a Wound
PART TWO: Wound Diagnosis
Chapter 4: Vascular Wounds
Chapter 5: Lymphedema
Chapter 6: Pressure Injuries and Ulcers
Chapter 7: Diabetes and the Diabetic Foot
Chapter 8: Atypical Wounds
Chapter 9: Flaps and Skin Grafts
Chapter 10: Burn Wound Management
Chapter 11: Factors That Impede Wound Healing
PART THREE: Wound Bed Preparation
Chapter 12: Wound Debridement
Chapter 13: Wound Dressings
PART FOUR: Biophysical Technologies
Chapter 14: Electrical Stimulation
Chapter 15: Negative Pressure Wound Therapy
Chapter 16: Ultrasound
Chapter 17: Pulsed Lavage with Suction
Chapter 18: Hyperbaric Oxygen Therapy
Chapter 19: Ultraviolet C
Chapter 20: Low-Level Laser Therapy --

Summary: This book combines clear explanatory text with a wealth of images of ECG recordings in order to provide an accessible, up-to-date source of information and guide to interpretation for all professionals seeking to increase their expertise in electrocardiography. ECG results are presented and discussed for a wide range of conditions, including all forms of arrhythmia, Wolff-Parkinson-White syndrome, bundle branch blocks, ischemic cardiomyopathy, atrial and ventricular enlargement, pericardial and myocardial diseases, diseases of the pulmonary circulation, and post pacemaker implantation. Normal ECG findings are fully described, and helpful introductory information is included on the principles of electrophysiology. The practically oriented text accompanying the ECG recordings covers both electrophysiological and clinical aspects. More than 100 years after its first use by Willem Einthoven, electrocardiography continues to be the first diagnostic tool applied in most cardiac patients. This text atlas provides a sound basis for the correct ECG interpretation essential for appropriate patient management.

Contents:
1 General principles of anatomy and cellular electrophysiology
2 ECG leads
3 Normal ECG
4 Electrogenesis of arrhythmias
5 Bradyarrhythmias
6 Tachyarrhythmias
7 Wolff-Parkinson-White syndrome
8 Bundle branch blocks
9 Genetically determined arrhythmias
10 Post pacemaker implantation
11 Ischemic cardiomyopathy
12 Atrial and ventricular enlargement
13 Pericardial and myocardial diseases
14 Diseases of the pulmonary circulation
15 ECG and special issues.

Contents:
v. 1. Head and neck
v. 2. Chest
v. 3. Abdomen
v. 4. Bones, joints and soft tissues.

Summary: A reliable, cost-effective approach to extracting priceless business information from all sources of text Excavating actionable business insights from data is a complex undertaking, and that complexity is magnified by an order of magnitude when the focus is on documents and other text information. This book takes a practical, hands-on approach to teaching you a reliable, cost-effective approach to mining the vast, untold riches buried within all forms of text using R. Author Ted Kwartler clearly describes all of the tools needed to perform text mining and shows you how to use them to identify practical business applications to get your creative text mining efforts started right away. With the help of numerous real-world examples and case studies from industries ranging from healthcare to entertainment to telecommunications, he demonstrates how to execute an array of text mining processes and functions, including sentiment scoring, topic modelling, predictive modelling, extracting clickbait from headlines, and more. You'll learn how to: -Identify actionable social media posts to improve customer service -Use text mining in HR to identify candidate perceptions of an organisation, match job descriptions with resumes, and more -Extract priceless information from virtually all digital and print sources, including the news media, social media sites, PDFs, and even JPEG and GIF image files -Make text mining an integral component of marketing in order to identify brand evangelists, impact customer propensity modelling, and much more Most companies' data mining efforts focus almost exclusively on numerical and categorical data, while text remains a largely untapped resource. Especially in a global marketplace where being first to identify and respond to customer needs and expectations imparts an unbeatable competitive advantage, text represents a source of immense potential value. Unfortunately, there is no reliable, cost-effective technology for extracting analytical insights from the huge and ever-growing volume of text available online and other digital sources, as well as from paper documents-until now.

Contents:
What is text mining?
Basics of text mining
Common text mining visualizations
Sentiment scoring
Hidden structures : clustering, string distance, text vectors & topic modeling
Document classification : finding clickbait from headlines
Predictive modeling : using text for classifying & predicting outcomes
The OpenNLP Project
Text sources.

Contents:
v. 1. Principles and methods. Cornea and anterior chamber
v. 2. Lens and zonule
v.3. Iris, vitreous body, conjunctiva.

Contents:
Part I: Role, scope, and standards of the Acute Care Nurse Practitioner. Role of the Acute Care Nurse Practitioner
Part II: Clinical practice of the Acute Care Nurse Practitioner: disorders of the body systems. Head, eyes, ears, nose and throat disorders ; Cardiovascular disorders ; Cardiovascular surgery ; Thoracic surgery ; Vascular disorders ; Pulmonary disorders ; Endocrine disorders ; Hematologic and oncologic disorders ; Gastrointestinal disorders ; Nutritional considerations in acute care ; Kidney disorders ; Genitourinary and gynecologic disorders ; Integumentary disorders ; Musculoskeletal disorders ; Neurologic disorders ; Psychosocial, behavioral, and cognitive health disorders
Part III: General clinical topics for the Acute Care Nurse Practitioner. Infectious diseases ; Management of traumatic injury in adults and older adults ; Fluids, electrolytes, and acid-base disorders ; Shock ; Poisoning and drug toxicity ; Solid organ transplantation ; Gerontological principles of aging
Part IV: Special considerations for adult-gerontology acute care nursing practice. Palliative and end-of-life care ; Pain and pain management.

Summary: This textbook is the new edition of Purnell's famous Transcultural Health Care, based on the Purnell twelve-step model and theory of cultural competence. This textbook, an extended version of the recently published Handbook, focuses on specific populations and provides the most recent research and evidence in the field. This new updated edition discusses individual competences and evidence-based practices as well as international standards, organizational cultural competence, and perspectives on health care in a global context. The individual chapters present selected populations, offering a balance of collectivistic and individualistic cultures. Featuring a uniquely comprehensive assessment guide, it is the only book that provides a complete profile of a population group across clinical practice settings. Further, it includes a personal understanding of the traditions and customs of society, offering all health professionals a unique perspective on the implications for patient care.

Contents:
Introduction
Part I. Foundations for Cultural Competence
Chapter 1. Transcultural Diversity and Health Care: Individual and Organizational
Chapter 2. The Purnell Model and Theory for Cultural Competence
Chapter 3. Individual Competence and Evidence-Based practice (with inclusion of the International Standards)
Chapter 4. Organizational Cultural Competence
Chapter 5. Perspectives on Nursing in a Global Context
Part II. Aggregate Data for Cultural-Specific Groups
Chapter 6. People of African American Heritage
Chapter 7. The Amish
Chapter 8. People of Appalachian Heritage
Chapter 9. People of Arab Heritage
Chapter 10. People of Chinese Heritage
Chapter 11. People of Cuban Heritage
Chapter 12. People of European American Heritage
Chapter 13. People of Filipino Heritage
Chapter 14. People of German Heritage
Chapter 15. People of Guatemalan Heritage
Chapter 16. People of Haitian Heritage
Chapter 17. People of Hindu Heritage
Chapter 18. People of Hmong Heritage
Chapter 19. People of Japanese Heritage
Chapter 20. People of Jewish heritage
Chapter 21. People of Korean Heritage
Chapter 22. People of Mexican Heritage
Chapter 23. People of Polish Heritage
Chapter 24. People of Puerto Rican Heritage
Chapter 25. People of Russian Heritage.

Summary: This book provides a systemic approach to acute trauma care in line with the ABCDE paradigm and up-to-date information on assessing and managing major trauma from the pre-hospital to the rehabilitation phase. The book's early sections are dedicated to identifying and managing pathology caused by massive haemorrhage, airway, breathing, circulation or neurological trauma and examining the current evidence base relating to their management. The book then builds from fundamental skills to advanced interventions so that each level of responder can identify and implement aspects of clinical practice that will be of benefit to them at their stage. This approach also explains advanced interventions that may be executed subsequently, explaining how each phase of care sits together. This has a further benefit of producing seamless care for patients by practitioners of different levels using this book as a reference point. Later sections deal with specifics of in-hospital trauma care by specialty, including the explanation of decision making processes by specialties, use of diagnostic and interventional radiology, rehabilitation and psychological aspects of trauma care. The Textbook of Acute Trauma Care also focuses on non-clinical issues relevant to trauma such as training and logistics of retrieval and repatriation, aviation considerations in HEMS, legal and forensic evidence considerations and ethical issues dealing with trauma patients. In addition, the book contains chapters from international experts on cognitive and human factors relating to healthcare and suggests strategies for training and minimising errors. This book is an essential resource for all grades of practitioner, from first responders to Consultant/Attending Physician level providers.

Contents:
Human factors in trauma care
Dealing with death in trauma
Legal and ethical issues in trauma care
The evolution of trauma systems
Point of injury to rehabilitation
Massive haemorrhage control
Fundamentals of airway management in trauma
Drug assisted airway management
Breathing and chest trauma
Circulation
Disability and head injury
Traumatic cardiac arrest
Pain management in trauma
Initial approach to damage control resuscitation
Haemostasis and coagulopathy
In hospital REBOA for major trauma
Anticoagulants in trauma
History of pre-hospital medicine in the UK
Aviation considerations in PHEM
Scene safety
Mechanism of injury
Mass casualty incidents
Tactical trauma care
Trauma retrieval
Sedation and field amputation
Point of care ultrasound (POCUS)
Diagnostic radiology in trauma --Interventional radiology in trauma
Decisions-making in damage control surgery
Practical considerations of damage control laparotomy
Trauma in the intensive care unit (ICU)
Spinal and neurological trauma
Limb trauma
Pelvic trauma
Trauma in pregnancy
Paediatric trauma
Silver trauma
Ballistics and blast injury
Immersion and submersion
Burns and thermal injuries
Environmental trauma: CBRN incidents
Decompression illness and diving medicine
Rehabilitation after trauma
Preventing and treating trauma-related mental health problems.

Summary: Addiction is increasingly being recognized as a major global public health issue, and an ever-growing number of medical specialties, psychological and social science training programs, and professional associations are including addiction as part of their training and continuing education curricula. The first edition of this book presented an overview of the spectrum of addiction-related problems across different cultures around the globe. Sharing the experience and wisdom of more than 260 leading experts in the field, and promoted by the International Society of Addiction Medicine, it compared and contrasted clinical practices in the field of addiction medicine on the basis of neurobiological similarities as well as epidemiological and socio-cultural differences. Building on the success of this inaugural edition, and taking into account the formal and informal comments received as well as an assessment of current need, this textbook presents general updated information while retaining the most requested sections of the first edition as demonstrated by the number of chapter downloads. It also provides a basic text for those preparing for the ISAM annual certification exam. Written by some 220 international experts, it is a valuable reference resource for anyone interested in medicine, psychology, nursing, and social science.

Summary: This primary text encompasses the full scope of AGNP primary care practice across multiple healthcare settings including telehealth. The text emphasizes the best available evidence to promote person-centered care, quality improvement of care, interprofessional collaboration, and reducing healthcare costs. The text delivers timely information about current healthcare initiatives in the U.S., including care coordination across the healthcare continuum, interprofessional collaboration, and accountable care organizations. Disease-focused chapters contain general and specific population-based assessment and interprofessional care strategies to both common and complex health issues. They offer consistent content on emergencies, relevant social determinants of health, and ethical dilemmas. The text also prepares students for the administrative aspects of practice with information on the physical exam, medications, billing, coding, and documentation. Concise, accessible information is supported by numerous illustrations, learning objectives, quality and safety alerts, clinical pearls, and case studies demonstrating best practice. A robust ancillary package includes an Instructor's Manual with case studies and teaching guides, a Test Bank reflective of clinical situations and patient conditions, PowerPoints covering key concepts, and an Image Bank of skin conditions and other figures. -- Provided by publisher.

Contents:
Part I. Basic sciences/physiology/histology
Part II. Molecular biology and metabolism
Part III. Endogenous and exogenous factors
Part IV. Disease state/conditions with aging
Part V. Techniques, methods, and tools
Part VI. Toxicology/safety and microbiology
Part VII. Genomics
Part VIII. Skin scales and typing system
Part IX. Skin health, nutrition, resilience, rejuvenation, and management of aging skin
Part X. Psychosocial implications
Part XI. Aging perception
Part XII. Gender, ethnicity, and lifestyle differences
Part XIII. Sensitive skin and aging
Part XIV. Ingredients, products, and cosmetics for aging skin beauty
Part XV. Cosmetic surgeries
Part XVI. Mind/skin/body interaction
Part XVII. Global market place, social and emotional aspects for the aged
Index.

Summary: Allergies are a significant health issue, yet few books exist on allergen tolerance of separation; here the author classifies allergen tolerance breakdown in specific types, according to the possibility that the autonomic breakdown of allergen tolerance in the unified airway depends on a deficit of pro-tolerogenic neurotransmitters at the local level. This paradigm, which explains the pathogenesis of allergic disorders, opens to new approaches to allergen-specific immunotherapy (AIT). While focusing on the new atopic disorders of the unified airway, such as local allergic rhinitis, "dual" allergic rhinitis, local allergic asthma, and local allergic conjunctivitis, the work combines clinical examples of allergic diseases and their treatment with their immunological background. The topics range from the specific immune-derived maintenance of allergen tolerance and the role of the neuroimmune network in allergic inflammation to conventional atopic diseases and more particular issues of local atopic disorders in the unified airway, oral tolerance, and its breakdown, and its translation in genitourinary aspects of allergic inflammation. Specific chapters are also devoted to allergen-specific immunotherapy (AIT) and anti-allergy treatments. Thought for upper graduate students, it will also be a valued resource for allergy practitioners, pulmonologists, ENT specialists, pediatricians, and translational researchers, Textbook of Allergen Tolerance includes classical didactic features such as abstracts, keywords, background notes, discussion points, and Q&A., as well as 20 audio files Text-to-Speech for the visually impaired, and 10 video to support the readers. .

Contents:
Chapter 1) Antigens and Allergens
Chapter 2) Immune Tolerance at a Glance
Chapter 3) Immune-Derived Maintenance of Allergen Tolerance
Chapter 4) The Role of the Neuroimmune Network in Allergic Inflammation
Chapter 5) Conventional Atopic Diseases
Chapter 6) Local Atopic Disorders in the Unified Airway
Chapter 7) Food Allergies and Oral Tolerance
Chapter 8) Allergen-Specific Immunotherapy (AIT)
Chapter 9) Allergen Tolerance in the Genitourinary Tract
Chapter 10) Allergies in Covid-19 and Post-Covid Syndrome.

Summary: The most current, comprehensive work available to date, the Textbook of Antisocial Personality Disorder is the definitive source of information on this difficult and often poorly understood and underdiagnosed disorder. A group of distinguished international experts, researchers, and clinicians provide their unique perspectives on what has been learned so far about antisocial personality disorder (ASPD) and other forms of antisocial behavior, including childhood conduct disorder, adult antisocial behavior, and psychopathy. Highly useful for both clinicians tasked with caring for these patients and researchers involved in probing its causes and treatments, the book looks at the phenomenology and natural course of ASPD, as well as its neuropathology, neurophysiology, genetic risk factors, epigenetics, and social determinants. The authors also explore some promising directions regarding prevention and treatment. Throughout the book, illustrative case vignettes provide a real-world view of people diagnosed with ASPD, including symptoms, course, and severity. In addition, tables, graphs, and illustrations further define the important points. Urgently needed and written with authority by those at the forefront of this vexing disorder, the Textbook of Antisocial Personality Disorder provides useful information on topics such as • The history and definition of ASPD• Clinical concepts such as epidemiology, comorbidity, symptoms, and course• Suspected causes of the disorder• Neurophysiology, neurotransmitters, and neuroimaging of the disease• The relationship of ASPD to psychopathy• Current treatment recommendations Special coverage is included on antisocial women, antisocial children, antisocial sexual offenders, forensic aspects of ASPD, and preventive strategies.-- Provided by publisher.

Contents:
Part I: Definitiona and History
Part II: Clinical Concepts
Part III: Etiology and Pathophysiology
Part
Part IV: Clinical Management
Part V: Special Problems, Populations, and Settings.

Summary: Groundbreaking, comprehensive, and developed by a panel of leading international experts in the field, Textbook of Assisted Reproduction provides a multidisciplinary overview of the diagnosis and management of infertility, which affects 15% of all couples around the world. The book aims to cover all aspects of assisted reproduction. Particular attention is given to topics such as the assessment of infertile couples; assisted reproductive techniques (ARTs) including ovulation induction, intra uterine insemination (IUI), in vitro fertilization (IVF) and intracytoplasmic sperm injection (clinical and laboratory aspects); reproductive genetics; and obstetric and perinatal outcomes.

Contents:
IVF Lite (Accuvit + PGT-A)
Relevance of Embryo Aneuploidy in Medically Assisted Reproduction
PGT-M for couples with a single gene disorder
PGT-A in Recurrent Miscarriage
Part IX: IVF Laboratory
Setting Up an IVF Laboratory
Air Quality in the IVF Laboratory
pH, Temperature, and Light
A Comparison of Embryo Culture Incubators for the IVF Laboratory
Quality Management Systems
Risk Management in Medically Assisted Reproduction
Screening for Infections Prior to Medically Assisted Reproduction
Treating Patients with Blood-Borne Viruses
Laboratory Aspects of In Vitro Maturation Cycles
Complications of Oocyte Retrieval
Follicular Flushing at Oocyte Retrieval in Medically Assisted Reproduction
Handling Unhealthy or Poor-Quality Sperm Samples in a Medically Assisted Reproduction Laboratory
Conventional IVF
ICSI: Yesterday, Today and Tomorrow
Sperm Selection Techniques for ICSI
Selecting Sperm with Hyaluronic Acid: Evidence Base for Efficacy and Practical Applications
Sperm Separation Protocols
Embryo Development: From Zygote to Blastocyst
Time-Lapse Monitoring
Index s and Unexplained Infertility
Human Leukocyte Antigens (HLA) Typing in Medically Assisted Reproduction
Medically Assisted Reproduction in Women with Bleeding Disorders
Bleeding Disorders and Medically Assisted Reproduction
Medically Assisted Reproduction in Organ Transplant Recipients
Ovarian Hyperstimulation Syndrome
Same-Sex Couples and Single Women Undergoing Medically Assisted Reproduction
Treating the Transgender Patient
Transvaginal Sonography Guided Management of Ectopic Pregnancies.-Part IV: Improving Outcomes in Medically Assisted Reproduction
Multiple Pregnancies as a Complication of Medically Assisted Reproduction
Multiple Birth Minimisation Strategies
Multifetal Reduction Following Medically Assisted Reproduction
Perinatal Outcome of ART Pregnancies
Effectiveness and Safety of Freeze All Strategy with Regard to Medically Assisted Reproduction and Perinatal Outcomes
Blastocyst Transfer for Everyone?
Endometrial Receptivity Testing
Androgens for Improving Ovarian Response to Stimulation
Part V: Third Party Reproduction
Oocyte Donation
Sperm Donation
Embryo Donation
Gestational Surrogacy
Uterus Transplantation: An Experimental Approach
Part VI: Fertility Preservation
Semen Cryopreservation: A Practical Guide
Cryopreservation of Human Embryos: Basic Principles and Current Considerations
Fertility Preservation in Pre-Pubertal Children
Fertility Preservation for Prepubertal Boys at Risk of Infertility
Recent Advances in Fertility Preservation
Prevention of Gonadotoxicity.-Ovarian Tissue Cryopreservation
Effects of Ethnicity on Ovarian Stimulation and Fertility Preservation
Managing a Sperm Cryobank
Managing an Embryo Cryobank
Part VII: Counselling
Psychological Aspects of Infertility
Counselling Prior to Medically Assisted Reproduction
Part VIII: Genetic Testing
Noninvasive Prenatal Testing: Current Status
Reproductive Genetics for the Clinician.-.

Summary: "More than 40 years after the official recognition of infantile autism in DSM-III, advances continue to be made in our understanding of the possible causes, assessment and evaluation, and treatment of autism spectrum disorder (ASD). With contributions by dozens of experts in the field, this second edition of the Textbook of Autism Spectrum Disorders has been updated to reflect the latest research in ASD. Unrivaled in its thoroughness, this volume discusses issues of assessment and evaluation; examines the etiology of ASD and its recognized associations with other medical conditions; analyzes standard and experimental treatments; and delves into social policy issues pertinent to individuals with ASD and those who treat them. With summary points in each chapter and copious lists of recommended readings, this is an indispensable resource for psychiatrists, psychologists, neurologists, social workers, speech therapists, educators, and all others in the continuum of care"-- Provided by publisher.

Contents:
Cover
Half Title
Title
Copyright
Contents
Contributors List
Foreword
PART I: Assessment, Evaluation, and Target Symptoms
Part 1A: AASSESSMENT AND EVALUATION
1 Epidemiology
2 Psychiatric Assessment and Treatment
3 Pediatric and Neurological Assessments
4 Gender Dysphoria, Gender Incongruence, and Sexual Identity
5 Racial and Ethnic Disparities in Assessment and Evaluation
6 Digital Biomarkers in Diagnostics and Monitoring
Part 1B: TARGET AND COMORBID SYMPTOMS
7 Social Communication
8 Diet and Nutrition
PART II: Causes
Part IIA: OVERVIEW 9 Genetics and Genomics
10 Epigenomics
11 Prenatal, Perinatal, and Parental Risk Factors
12 Animal Models
13 Electrophysiological Studies
14 Environmental Toxicity and Immune Dysregulation
Part IIB: SYNDROMIC CAUSES
15 Overview of Syndromic Causes of ASD and Commonalities in Neurobiological Pathways
16 Fragile X Syndrome and Associated Disorders
17 Tuberous Sclerosis Complex
18 16p11.2 and Other Recurrent Copy Number Variants Associated With ASD Susceptibility
19 Rett Syndrome
20 Prader-Willi Syndrome
Part IIC: IMAGING AND ANATOMY 21 Neuroanatomical Findings
22 The Amygdala in ASD
23 Neurobiology of ASD Informed by Structural Imaging Research
24 Positron Emission Tomography
25 Functional Magnetic Resonance Imaging
PART III: Treatments and Interventions
Part IIIA: STANDARD PHARMACOLOGICAL TREATMENTS
26 Serotonergic Medication
27 Antipsychotics
28 Treating Hyperactivity in Children With Pervasive Developmental Disorders
Part IIIB: EXPERIMENTAL THERAPEUTICS
29 Complementary and Integrative Approaches
30 Oxytocin
31 Vasopressin
32 N-Acetylcysteine 33 Arbaclofen: From Animal Models to Clinical Trials
34 Cannabis, Cannabinoids, and Immunomodulatory Agents
Part IIIC: BEHAVIORAL AND EDUCATIONAL INTERVENTIONS
35 Behavioral Treatments
36 Early Start Denver Model
37 The Developmental, Individual Difference, Relationship-Based Intervention Model: A Comprehensive Parent-Mediated Approach
38 School-Based Interventions
39 Language and Communication: Challenges and Treatments
Part IIID: FUTURE TREATMENT DEVELOPMENTS
40 Transcranial Magnetic Stimulation
41 Stem Cell and Gene Therapy 42 Gene Therapy and Molecular Interventions
PART IV: Consortiums, Employment, and Advocacy
43 Consortiums
Developing Precision Medicine Approaches to ASD
Autism Biomarkers Consortium for Clinical Trials
Interactive Autism Network
44 Autism Strengths and Neurodiversity
45 Role of Patient Advocacy Groups in Treatment Development
Index
Plates
Back Cover