Books

Point and click your way to performing statistics! Many people are intimidated by learning statistics, but A Gentle Introduction to Statistics Using SAS Studio in the Cloud is here to help. Whether you need to perform statistical analysis for a project or, perhaps, for a course in education, psychology, sociology, economics, or any other field that requires basic statistical skills, this book teaches the fundamentals of statistics, from designing your experiment through calculating logistic regressions. Serving as an introduction to many common statistical tests and principles, it explains concepts in an intuitive way with little math and very few formulas. The book is full of examples demonstrating the use of SAS Studio's easy point-and-click interface accessed with SAS OnDemand for Academics, an online delivery platform for teaching and learning statistical analysis that provides free access to SAS software via the cloud. Topics included in this book are: How to access SAS OnDemand for Academics Descriptive statistics One-sample tests T tests (for independent or paired samples) One-way analysis of variance (ANOVA) N-way ANOVA Correlation analysis Simple and multiple linear regression Binary logistic regression Categorical data, including two-way tables and chi-square Power and sample size calculations Questions are provided to test your knowledge and practice your skills.

Caring for critically ill children and their families -- Pulmonary system -- Cardiovascular system -- Neurologic system -- Renal system -- Endocrine system -- Gastrointestinal system -- Hematology and immunology systems -- Multisystem issues -- Professional issues: quality, safety, work environment, and wellness.

"Succinct, complete guidance on how to safely and competently care for adult, critically ill patients and their families written by top clinical experts. Endorsed by the American Association of Critical-Care Nurses (AACN), this acclaimed textbook sets the standard for critical care nursing education. Recognizing the learner's need to assimilate foundational knowledge before attempting to master more complex critical care nursing concepts, the book features a practical building-block organization that starts with the basics and logically progresses to advanced topics. Bolstered by helpful tables and essential content cases, AACN Essentials of Critical Care Nursing is an essential tool for clinicians at the point of care, and those preparing for CCRN® certification in critical care nursing. AACN Essentials of Critical Care Nursing, Fourth Edition is presented in four sections: The Essentials presents core information that new clinicians must understand to provide safe, competent nursing care to all critically ill patients, regardless of their underlying medical diagnoses. Pathologic Conditions covers pathologic conditions and management strategies commonly encountered among adult critical care patients. Advanced Concepts in Caring for the Critically Ill Patient moves beyond the essentials and includes information about specific pathologic conditions that require specialized critical care management. Key Reference Information features normal laboratory and diagnostic values, troubleshooting guides for hemodynamic monitoring, summary tables of critical care drugs, and cardiac rhythms and treatment guides. Learning aids include Knowledge Competencies that can be used to gauge progress, Principles of Management to summarize key concepts and "Essential Content" case studies with questions and answers to further reinforce the learners' knowledge"-- Provided by publisher.

The AACN Procedure Manual for High Acuity, Progressive, and Critical Care, 7th Edition, authored by the American Association of Critical-Care Nurses, is the authoritative reference to procedures performed in high acuity, progressive, and critical care settings. It visually guides you through procedures unique to the adult critical care environment, including those performed by advanced practice nurses, in an illustrated, step-by-step format. This edition features 17 new procedures, new illustrations, and updated content throughout, reflecting the latest evidence-based guidelines and national and international protocols.

Vol. 1 Contains standards for equipment, decontamination of medica by steam, ethylene oxide, gamma radiation, and electron beam radiation. -- Vol. 2 Contains standards for biomedical equipment. -- Vol. 3 Contains all documents developed under the auspices of the Renal Disease and Detoxification Committee and Hemodialyzer Reuse Submittee.

"AAOS Comprehensive Orthopaedic Review, 3rd edition offers sweeping coverage of the core of orthopaedic knowledge that spans the spectrum of the orthopaedic specialties. This convenient, comprehensive and user-friendly text combines the specific information you need to prepare for your examination. Study to prepare for your Board Exam! This 3-volume study set is designed to prepare orthopaedic residents for the Orthopaedic In Training Exam (OITE), and the American Board of Orthopaedic Surgery (ABOS) Board Certification examination. Dr. Lieberman and his editorial team of Board-certified orthopaedic surgeons edited and present this thorough text in a concise outline format, giving you ready access to the important facts as a quick bulleted review of the concepts you need to know. Study to retain knowledge! With relevant content developed and updated by over 400 physician contributors and editors, this third edition reinforces what you've learned on your daily rounds and skills labs. Organized by specialty, each of the 149 chapters is loaded with color images, illustrations, tables, and charts to support the material and help you retain the information. Study to achieve proficiency! Pinpoint areas for further study by self-testing with nearly 500 multiple-choice companion study questions. Each question includes the preferred response with additional discussion and explanation of the topics. This set is your ideal exam study prep program"--Provided by publisher.

The AAP Healthy Development and Well-Child Support Chart provides pediatric health professionals with a quick and easy-to-use reference on some of the most important areas covered in the pediatric well-child visit.

I. User Guide -- II. Parameters to be reported for polysomnography -- III. Technical and digital specificatioins -- IV. Sleep staging rules -- Part 1. Rules for adults -- Part 2. Rules for children -- Part 3. Rules for infants -- V. Arousal rule -- VI. Cardiac rules -- VII. Movement rules -- VIII. Respiratory rules -- Part 1. Rules for adults -- Part 2. Rules for children -- IX. Home sleep apnea testing (HSAT) rules for adults -- Part 1: HAST utilizing repiratory flow and/or effort parameters -- Part 2: HSAT utilizing peripheral arterial tonometry (PAT) -- X. Development process -- XI. Procedural notes -- XII. Glossary ot terms.

Introduction to abbreviated breast magnetic resonance imaging / Christopher E. Comstock -- History of MRI in breast cancer screening / Janice S. Sung and Elizabeth A. Morris -- Current clinical evidence on abbreviated breast MRI / Christiane Kuhl -- Technical aspects of abbreviated breast MRI : the original approach / Christiane Kuhl -- Techniques for performing abbreviated breast MRI / R. Edward Hendrick -- Abbreviated breast MR imaging protocols and clinical implementation / Gillian M. Newstead -- Interpretation guidelines / Janice S. Sung and Constance D. Lehman -- MRI-guided biopsy techniques / Carol H. Lee.

This book describes 83 theories of behaviour change, identified by an expert panel of psychologists, sociologists, anthropologists and economists as relevant to designing interventions. For each theory, the book provides a brief summary, a list of its component constructs, a more extended description and a network analysis to show its links with other theories in the book. It considers the role of theory in understanding behaviour change and its application to designing and evaluating interventions.

ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.

Clear and concise, this easy-to-use book offers an introductory course on the language of gene cloning, covering microbial, plant, and mammalian systems. It presents the nuts and bolts of gene cloning in a well-organized and accessible manner. Part I of this book outlines the essentials of biology and genetics relevant to the concept of gene cloning. Part II describes common techniques and approaches of gene cloning, ranging from the basic mechanics of DNA manipulation, vector systems, process transformation, to gene analysis. Part III & IV present application technologies of major impact in agriculture, biomedicine, and related areas. The ABCs of Gene Cloning, Third Edition contains updates including a tutorial chapter on gene-vector construction, methodologies on exome sequencing in finding disease genes, revised topics on gene therapy and whole genome sequencing, new developments for gene targeting and genome editing, as well as the current state of next generation sequencing. With more than 140 illustrations, this new edition provides an invaluable text for students and anyone who have interest in gaining proficiency in reading and speaking the language of gene cloning.

Covers novel, state-of-the-art strategies in engineering and clinical analysis. Explores approaches for analyzing abdominal imaging, including lung, mediastinum, pleura, liver, kidney and gallbladder. Offers present and future applications as applied to the abdomen and thoracic imaging with the most world-renowned scientists in these fields.

In this book a team of leading experts come together to provide a comprehensive overview of modern imaging of the abdomen and pelvis, with detailed sections on both gastrointestinal and genitourinary imaging. Each chapter has an identical structure and focuses on a particular organ or organ system, allowing the reader to approach the field one topic at a time. Indications for a variety of imaging techniques and examination protocols are clearly described, and the imaging features of normal anatomy and pathologic entities are depicted in an abundance of high-quality images. Care is taken to consider all recent technical developments and new indications, and the diagnostic performance of different imaging modalities is carefully compared. It is anticipated that this book will come to be regarded as the standard work of reference on abdominal and pelvic radiology.

Abdominal radiography -- Gastrointestinal fluoroscopy -- Gastric wall thickening/masses -- Hollow viscus perforation -- Small bowel obstruction -- Bowel wall thickening -- Imaging of the postoperative bowel -- Mesenteric ischemia -- Colorectal cancer and screening -- Right upper quadrant pain -- Right lower quadrant pain -- Pancreatitis -- Solid pancreatic masses -- Cystic pancreatic lesions -- Chronic liver disease -- Imaging of the cirrhotic liver -- Benign focal liver lesions -- Cholecystitis -- Jaundice -- Splenomegaly/splenic lesions -- Lymphadenopathy -- Urolithiasis -- Cystic renal masses -- Solid renal lesions -- Diffuse renal parenchymal disorders -- Urinary tract obstruction -- Urothelial lesions -- Adrenal gland enlargement and nodules -- Prostate imaging -- Testicular lesions -- Endometrial/junctional zone thickening -- Focal uterine lesions -- Cystic adnexal lesions -- Solid adnexal lesions -- Müllerian abnormalities -- Pelvic floor disease -- Postoperative imaging -- Abdominal/pelvic trauma -- Pitfalls.

Diagnostic approach to protocoling and interpreting MR studies of the abdomen and pelvis -- Liver -- Gallbladder and biliary system -- Pancreas -- Spleen -- Gastrointestinal tract -- Peritoneal cavity -- Adrenal glands -- Kidneys -- Retroperitoneum and body wall -- Bladder and nongender pelvis -- Male pelvis -- Female urethra and vagina -- Uterus and cervix -- Adnexa -- Maternal conditions in pregnancy -- Fetus -- Chest -- Contrast agents -- Magnetic resonance-positron emission tomography (MR-PET).

Classification and principals of treatment -- Inflammatory mediators in Intra-abdominal sepsis -- Intra-abdominal sepsis and imaging considerations -- High-risk patients and prognostic factors for abdominal sepsis -- Acute appendicitis: what is the best strategy to treat acute appendicites (both complicated and uncomplicated)? -- Acute cholecystitis -- Acute cholangitis -- Pyogenic liver abscess -- Gastroduodenal perforations -- Small bowel perforations -- Acute colonic diverticulitis -- Postoperative peritonitis: etiology, diagnosis, and treatment -- Damage control surgery in managing abdominal sepsis (Fausto Catena, Italy) -- Ongoing peritonitis -- Evolving treatment strategies for severe Clostridium difficile colitis: defining the therapeutic window -- Complicated intra-dominal infections: principles of antimicrobial therapy -- Antimicrobial armamentarium -- Antimicrobial resistance in intra-abdominal infections -- The role of Candida in abdominal sepsis -- The value and interpretation of microbial specimens in the management of cIAI -- Appropriate antimicrobial therapy in critically ill patients -- Hemodynamic support -- Adjunctive therapies in abdominal sepsis -- Impact and management of abdominal compartment syndrome in patients with abdominal sepsis -- Thromboprophylaxis in patiens with abdominal sepsis -- Nutritional support for abdominal sepsis.

1. Immunosuppression in solid organ transplantation -- 2. Infection Complications after Abdominal Organ Transplantation -- 3. National Transplant Network. Donor selection and evaluation criteria -- 4. The safety of donor -- 5. Medical disease after abdominal solid organ transplantation and the risk of solid and hematologic malignant tumor after transplantation) -- 6 Indication and timing -- 7. The donor procurement -- 8. Orthotopic liver transplantation -- 9. Anesthetic and perioperative management for liver transplantation -- 10 Living donor liver transplantation -- 11. Hepatic Acute and chronic rejection -- 12. Postoperative technical complications -- 13. Percutaneous management of biliary and vascular complications -- 14. Re-transplantation (Causes, Outcome) -- 15. Indication and timing -- 16. The donor procurement: Standard technique for procurement in cadaveric donors -- 17. Live donor evaluation -- 18. Living donor nephrectomy -- 19. Renal Transplantation: Surgical technique -- 20. The intraoperative and perioperative management of Kidney transplantation -- 21. Kidney acute and chronic rejection -- 22. Kidney Transplantation: Post-Operative Technical Complications -- 23. Indications and timing -- 24. The donor procurement -- 25 Transplantation -- 26 Abdominal wall transplantation and technique -- 27. Anesthetic and perioperative management for Intestinal transplantation -- 28. Segmental Living-related Small Bowel Transplantation -- 29. Intestinal Acute and Chronic rejection -- 30. Combined Kidney-Liver Transplantation -- 31. Kidney-pancreas Transplantation.

General -- Basic physical and technical principles -- Blood vessels : the aorta and its branches, the vena cava and its tributaries -- Liver -- Porta hepatis -- Gallbladder -- Pancreas -- Stomach, duodenum, and diaphragm -- Spleen -- Kidneys -- Adrenal glands -- Bladder, prostate, and uterus -- Quick guide -- The sono consultant -- Documentation.

Abdominal Ultrasound for Surgeons provides a comprehensive guide to the use of ultrasonography in surgical practice of abdominal diseases. The content is divided into three major sections focusing on basic principles of ultrasound, ultrasound anatomy and pathology of the abdomen, and employment of ultrasound of the abdomen in surgical practice. A final section is dedicated to the logistics of incorporating ultrasound into a surgical practice. The first section provides an introduction to the principles of ultrasonography focusing on ultrasound physics, equipment, and instrumentation. A detailed approach to the various scanning methods and image interpretation is demonstrated with illustrations, images, and video. The second section focuses on ultrasound anatomy of the abdomen. Each chapter demonstrates the normal and abnormal ultrasound anatomy of specific abdominal organ or organ systems (abdominal wall, liver, pancreas, biliary, stomach, anorectum, retroperitoneum, vascular) with illustrations and images. The current status and technique of endoscopic ultrasound of the upper and lower gastrointestinal tracks is addressed in this section. The third section provides a state-of-the-art review of the status of each major application of abdominal ultrasound in surgery. Topics range from trauma ultrasound and laparoscopic staging to techniques in ultrasound guidance and three-dimensional targeting. This section provides a comprehensive review of the employment of interventional, intraoperative, laparoscopic, transabdominal and endoscopic ultrasound. The fourth and last section addresses the practice aspects of incorporation of ultrasound into a surgical practice. Abdominal Ultrasound for Surgeons will serve as a very useful resource and guide for surgeons and students with little to some experience in ultrasound, including practicing surgeons, surgical fellows, and surgical residents.

This book presents different patient-oriented perspectives from surgeons, economic evaluation and management researchers, and business companies active in the healthcare sector, striking a balance between the appropriateness/effectiveness of treatment and efficiency/cost. It does not include technical surgical details, but instead provides the necessary knowledge regarding different groups of patients to help economic and management researchers make accurate evaluations. Although partially based on the specific case of abdominal wall surgery in the Italian health system, the book defines a model that can, with the necessary adaptations, be applied in other national contexts. It also analyzes different reimbursement systems and methods of data collection. This approach supports the evolution form evidence-based medicine (EBM) to the future of real-world data (big data analysis). Further, it highlights the critical issue of "silos" reimbursement, which is the pillar of DRG, and proposes methodology to evaluate the direct and indirect benefit and costs of surgery (for example quality of care, costs incurred in cases of surgical complications due to the use of inappropriate, low-cost material or due to surgical procedure. It is a valuable resource for clinicians, surgeons, policymakers and managers in the field.

"Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up"--Publisher's description.

pt. I. Science of clinical oncology -- sect. A. Biology and cancer -- sect. B. Genesis of cancer -- sect. C. Diagnosing cancer -- sect. D. Preventing and treating cancer -- pt. II. Problems common to cancer and its therapy -- sect. A. Hematologic problems and infections -- sect. B. Metabolic and paraneoplastic syndromes -- sect. C. Local effects of cancer and its metastasis -- sect. D. Complications of therapy -- sect. E. Special populations -- pt. III. Specific malignancies.

I. General topics -- Are you ready for your surgical rotation? -- Cardiopulmonary resuscitation -- How to treat all cardiac dysrhythmias -- How to think about shock -- Congestive heart failure (CHF) and pulmonary insufficiency -- Mechanical ventilation -- Why get arterial blood gases? -- Fluids, electrolytes, Gatorade, and sweat -- Nutritional assessment, parenteral, and enteral nutrition -- What does postoperative fever mean? -- Surgical wound infection -- Priorities in evaluation of the acute abdomen -- Surgical infectious disease -- Risks of blood-borne disease -- Sepsis -- Frailty -- II. Trauma. Initial assessment -- Posttraumatic hemorrhagic shock -- Traumatic brain injury -- Spinal cord injuries -- Penetrating neck trauma -- Blunt thoracic trauma -- Penetrating thoracic trauma -- Blunt abdominal trauma -- Penetrating abdominal trauma -- Hepatic and biliary trauma -- Splenic trauma -- Pancreatic and duodenal injury -- Trauma to the colon and rectum -- Pelvic fractures -- Upper urinary tract injuries -- Lower urinary tract injury and pelvic trauma -- Extremity vascular injuries -- Facial lacerations -- Maxillofacial trauma -- Basic care of hand injuries -- Burns -- Pediatric trauma -- III. Abdominal surgery. Appendicitis -- Gallbladder disease -- Pancreatic cancer -- Acute pancreatitis -- Diagnosis and therapy of chronic pancreatitis -- Portal hypertension and esophageal varices -- Gastroesophageal reflux disease -- Esophageal cancer -- Acid-peptic ulcer disease -- Small bowel obstruction -- Intestinal ischemia -- Diverticular disease of the colon -- Acute large bowel obstruction -- Inflammatory bowel disease -- Upper gastrointestinal bleeding -- Lower gastrointestinal bleeding -- Colorectal polyps -- Colorectal carcinoma -- Anorectal disease -- Inguinal hernia -- Bariatric surgery -- IV. Endocrine surgery. Hyperparathyroidism -- Hyperthyroidism -- Thyroid nodules and cancer -- Surgical hypertension -- Adrenal laparoscopic adrenalectomy incidentaloma -- V. Breast surgery. Breast masses -- Primary therapy for breast cancer -- VI. Other cancers. What is cancer? -- Melanoma -- Non-melanoma skin cancer -- Parotid tumors -- Neck masses -- VII. Vascular surgery. What is atherosclerosis? -- Arterial insufficiency -- Carotid disease -- Abdominal aortic aneurysm -- Venous disease -- Noninvasive vascular diagnostic laboratory -- VIII. Cardiothoracic surgery. Coronary artery disease -- Mitral stenosis -- Mitral regurgitation -- Aortic valvular disease -- Thoracic surgery for non-neoplastic disease -- Lung cancer -- Solitary pulmonary nodule -- Dissecting aortic aneurysm -- IX. Pediatric surgery. Hypertrophic pyloric stenosis -- Intestinal obstruction of neonates and infants -- Tracheoesophageal malformations -- Tracheoesophageal malformations -- Congenital diaphragmatic hernia -- Abdominal tumors -- Congenital cysts and sinuses of the neck -- X. Transplantation. Liver transplantation -- Kidney and pancreas transplantation -- Heart transplantation -- Mechanical circulatory support -- Lung transplantation -- Penile and scrotal urologic emergencies -- Urolithiasis -- XI. Urology. Renal cell carcinoma -- Bladder cancer -- Prostate cancer -- Urodynamics and voiding dysfunction -- Pediatric urology -- XII. Health care. Can health care be reformed? -- Ethics in the surgical intensive care unit -- Professionalism -- Required reading.

The natural environment for plants is composed of a complex set of abiotic and biotic stresses; plant responses to these stresses are equally complex. Systems biology allows us to identify regulatory hubs in complex networks. It also examines the molecular "parts" (transcripts, proteins and metabolites) of an organism and attempts to combine them into functional networks or models that effectively describe and predict the dynamic activities of that organism in different environments. This book focuses on research advances regarding plant responses to abiotic stresses, from the physiological level to the molecular level. It highlights new insights gained from the integration of omics datasets and identifies remaining gaps in our knowledge, outlining additional focus areas for future crop improvement research. Plants have evolved a wide range of mechanisms for coping with various abiotic stresses. In many crop plants, the molecular mechanisms involved in a single type of stress tolerance have since been identified; however, in order to arrive at a holistic understanding of major and common events concerning abiotic stresses, the signaling pathways involved must also be elucidated. To date several molecules, like transcription factors and kinases, have been identified as promising candidates that are involved in crosstalk between stress signalling pathways. However, there is a need to better understand the tolerance mechanisms for different abiotic stresses by thoroughly grasping the signalling and sensing mechanisms involved. Accordingly, this book covers a range of topics, including the impacts of different abiotic stresses on plants, the molecular mechanisms leading to tolerance for different abiotic stresses, signaling cascades revealing cross-talk among various abiotic stresses, and elucidation of major candidate molecules that may provide abiotic stress tolerance in plants.

This book introduces the clinical application of ABO-incompatible transplantation. In the first part, it starts with the history, blood group antigen, antibody associated with ABO blood type, pathophysiology and pathology and related knowledge. In the second part, it covers clinical experience sharing of ABO-incompatible of heart, liver, lung and kidney transplantation. It provides a systematic methodologies and protocols. .

"Abrahams' and McMinn's Clinical Atlas of Human Anatomy, 8th Edition delivers the straightforward visual guidance you need to perform confidently in all examinations and understand spatial relationships required during your medical training, while also acquiring the practical anatomical knowledge needed for your future clinical career. Respected authority Prof. Peter Abrahams and his team of leading international anatomists and radiologists link a vast collection of clinical images to help you master all the essential correlations between the basic science of anatomy and its clinical practice"--Publisher's description.

"The 'Interventional Radiology' volume of the landmark reference "Abrams' Angiography" has now been expanded and thoroughly revised to reflect dynamic advances in interventional radiology. More than 60 contributors representing a "Who's Who" of the specialty provide comprehensive, step-by-step coverage of all contemporary vascular and nonvascular interventional procedures. Major sections discuss today's equipment and describe interventions for specific disorders of each organ system, as well as for trauma, pediatric diseases, abscess drainage, and miscellaneous disorders. More than 1,100 illustrations complement the text. This edition incorporates an extensive new section on interventional oncologic procedures. The section covers all organ-specific cancers for which interventional therapies are used. Other sections include artervenous malformations, liver diseases, arterial occlusive disease, aneurysms, traumatic arterial injuries, hemorrhage, and venous diseases. It also has full color and an accompanying online site to access the content anytime"--Provided by publisher.

"Urodynamics has two basic aims: To reproduce the patient's symptomatic complaints while making key observations. To provide a pathophysiological explanation by correlating the patient's symptoms with the urodynamic findings. These two basic aims are crucial to the purpose of urodynamics - essentially it is a diagnostic test that will aid in the management of patients. The need to make urodynamic observations reflects the fact that the patient's symptoms are important, but they might be somewhat misleading. Most patients with lower urinary tract dysfunction (LUTD) present to their doctor with symptoms. However, lower urinary tract symptoms (LUTS - Table 1) should not simply be taken at face value, since a range of differing mechanisms may result in rather similar symptomatic presentations. The statement "the bladder is an unreliable witness" (1) reflects how symptoms are the starting point, but do not actually identify the ultimate explanation. Since treatment should correct the underlying cause, it is necessary to identify mechanisms, avoiding assumption or prejudice coming from taking symptoms at face value. An excellent example of this is voiding LUTS in men, where the cause on urodynamic testing may prove to be bladder outlet obstruction (BOO) and/or detrusor underactivity (DUA); BOO should respond fully to surgery to relieve obstruction such as transurethral resection of prostate (TURP), while such surgery is potentially not helpful in the second (2). Voiding LUTS in males are of unreliable diagnostic value, and only slow stream and hesitancy show any correlation with the urodynamic findings of BOO (3-5). Even with flow rate assessment, one cannot be sure whether BOO is present [Figure 1.1]. The difficulty of assessing LUTD by symptoms alone is the uncertainty about establishing truly what is going on in the individual describing them"-- Provided by publisher

For more than 40 years, Auditory Brainstem Responses (ABRs) have been used as a diagnostic tool for hearing disorders and brainstem disorders in the pediatric audiology and neurotology and child neurology. While there are many publications in this field, this new volume will review hearing problems and neurological disorders in babies, infants and children, and discuss important new advances such as ABR figure and threshold changes with infant development. The book will also cover auditory neuropathy, its numerous and new sub-classifications. Readers will be thoroughly briefed on all the new perspectives in interpreting data. Researchers and clinicians will find the text to be a valuable tool in the correct diagnosis of hearing problems and neurological diseases among babies and infants.

A high-yield review for the American Board of Surgery In-Training Exam, this text is a comprehensive review for the American Board of Surgery in-Training Exam. It delivers everything needed to excel on the exam: test-taking tips, high-yield facts, more than 300 multiple-choice questions, clinical pearls, illustrations of key anatomy, and bullet point text. Features: focused exclusively on the ABSITE exam, rather than being a combined ABSITE and board review book; organized by organ system; and valuable as last-minute review or a general framework for preparing for the exam.

"High yield review for the American Board of Surgery In-Training Exam"-- Provided by publisher.

This book serves as a tool for general psychiatrists, medical students, residents, and fellows looking for a clinically relevant and high-yield overview of addiction psychiatry in preparation for their board exams - or for everyday clinical practice. Written by expert educators in addiction psychiatry, the text is organized by substances misused and populations affected. This book serves as both a primary learning tool for those new to the field, as well as a reference for those working in addiction treatment. Each chapter begins with summaries of high yield clinical pearls, followed by general information including treatment, and then ends with accompanying board-style review questions. The scope includes understanding substances of misuse and substance use disorders (SUDs), how to evaluate, diagnose, and monitor SUDs, how to treat SUDs both pharmacologically and behaviorally, and critical information for specific populations of patients. Absolute Addiction Psychiatry for Clinical Practice and Review is an excellent resource for all medical students, residents, fellows, and professionals taking certification exams in addiction, including those in psychiatry, addiction medicine, emergency medicine, internal medicine, pain medicine, and others. The chapter "Laboratory Testing for Substance Use Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book offers a comprehensive review of allergy and immunology, specifically dedicated as a board review preparation. The book is a collective effort and participation of over 90 well known allergists, immunologists, and rheumatologist who are academician and or practitioners. Chapters are presented in a " Case-Based" format. Each chapter presents 2 cases; each case is followed by multiple choice questions/ answers and discussions. Each chapter also offers a list of specific references used in the text, that will enhance the readers' portfolio of resources. Allergy and Immunology Board Review is a must-have resource for allergy & immunology fellows-in-training and all allergy practitioners as well as any medical provider including residents, medical students and allied health who rotate in allergy divisions.

This concise review book provides a set of evidence-based and up-to-date study questions that demonstrate knowledge of common neurological diseases. Presented in a case-based format, each chapter includes several questions that are intended for medical students, residents rotating through neurology, and neurologists looking for study sources. Filling a need for a supplemental resource to use when studying for board exams, particularly the NBME and RITE, Absolute Case-Based Neurology serves as an invaluable guide to neurology rotations, tests and daily practice.

This book contains the most essential information needed for an epilepsy/ EEG rotation. Chapters are formatted with bullet points and feature clinical pearls. Concise and easy-to-read, this quick reference provides neurology residents, clinical neurophysiology and epilepsy fellows, and other clinicians with the most critical information in epilepsy and EEG in a simplified, yet comprehensive format. Divided into two sections, the book first covers the diagnosis, characteristics, and treatment of epilepsy. The second section focuses on EEG placement, procedures, and patterns in various neurological disorders.

This book provides a comprehensive yet concise review of geriatric psychiatry in preparation for the board exam, or for reference during practice. Written by experts in the field, this text thoroughly reviews over 500 developmental, biological, diagnostic, and treatment questions for board certification. Unlike any other text on the market, this book takes a broader approach to the subject, making it accessible for physicians as well as other clinicians, including nurses, therapists, and social workers. Absolute Geriatric Psychiatry Review is an excellent resource for all clinicians who will care for the mental health of aging patients, including psychiatrists, neurologists, psychologists, therapists, nurses, social workers, nursing home administrators, and all others.

This concise guide covers the evolution and expanding scope of hospital medicine and the variety of clinical, ethical and administrative situations a Hospitalist encounters. 500 questions on inpatient care, co-management of patients and hospital system management are provided with the goal of assessing clinical and academic competency. Questions feature actual cases with evidence-based solutions. Useful to physicians, house staff and advanced nurse practitioners, this up-to-date referenced learning text encompasses all aspects of hospital care.

Written in a succinct question and answer format, this comprehensive resource covers all areas of nephrology and common clinical scenarios. Nearly 1000 questions with detailed answers provide nephrology fellows, practicing nephrologists and clinicians a better understanding of nephrology and aid preparations for nephrology and internal medicine boards. Absolute Nephrology Review features the latest evidence and guidelines while fulfilling a critical need within the nephrology community.

Written in a succinct question and answer format, this comprehensive book is a resource on all areas of nephrology and common clinical scenarios. The updated volume covers the basic physiology of fluids, electrolytes and acid-base problems, renal disorders and management, chronic kidney disease, hypertension, and other essential subjects. The nearly 1000 detailed questions and answers prepare readers for nephrology and internal medicine boards and provide a better understanding of nephrology as a whole. This new edition of Absolute Nephrology Review features the latest evidence and guidelines needed by nephrology fellows, practicing nephrologists, and clinicians.

This practical question and answer book covers topics within the field of neurocritical care, including aspects of neurology, neurosurgery, general critical care, and emergency medicine. Each chapter serves as a standalone test, comprised of approximately 100 questions, and closely mimics the tone and scope of the United Council for Neurologic Subspecialties (UCNS) certification exam in neurocritical care. Rationale and discussion are provided in the answers section at the end of each exam. This practical study guide will help prepare critical care fellows and residents from a variety of backgrounds (including internal medicine, neurology, anesthesiology, and emergency medicine) for the UCNS exam.

This practical book features more than 1000 questions and answers with illustrations for pediatric neurologists, adult neurologists, general pediatricians and students taking their initial board examination and maintenance of certification. All questions are in multiple choice format and followed by the correct answer with a full explanation and appropriate references. Chapters are sectioned by different topics in pediatric neurology, including Epilepsy, Metabolic Disorders and Movement Disorders and other topics. Timely and thorough, this is a handy and succinct resource.

This book provides a concise and up-to-date review of key rheumatology topics along with extensive practice questions to assist in preparing for the American Board of Internal Medicine (ABIM) Rheumatology Certification Exam. Each chapter focuses on a single disease and starts with a short review (primarily tables and figures) to highlight the main points and key issues. The review is followed by 10-20 board-style multiple choice questions with detailed explanations for each topic. The chapters and associated preparation questions are written by established experts from top institutions in the United States. The book concludes with a 50-question practice test reflecting the format used by the ABIM Board Certification Exam. Absolute Rheumatology Review is an essential resource for not only graduate students, residents, and fellows in rheumatology and internal medicine studying for board exams but also rheumatologists, physicians, and related professionals preparing for recertification.

1. [Symposia I-III] -- 2. [Symposia IV-VII] -- 3. Colloquia I-XIV -- 4. General sessions A-F -- 5. General sessions G-J -- [6] Author index -- [7] Supplement I-

"The seventh biennial Harrison Survey, jointly sponsored by the Association of American Medical Colleges (AAMC) and the Society for Academic Continuing Medical Education (SACME), documents an academic enterprise that displays three major characteristics, somewhat in opposition to its traditional image as an isolated, passive educational entity. First, continuing medical education/ continuing professional development (CME/CPD) is increasingly integrated into the functions and missions of academic medical centers, academic health systems, and medical schools of the United States and Canada. Second, it demonstrates numerous examples of innovation and scholarship in educational design and operation. Finally, possibly as a result of the first two elements, there is an increased focus on assessing the impact of CME/CPD activities on learner competence, performance, and health care outcomes. The purpose of the survey is to help identify and understand the placement and alignment of the CME/CPD unit within the academic medical center (AMC). Survey findings will benefit those in the CME/CPD field who can use the data to assess and enhance the shape and scope of CME/CPD and who will share the information with AMC leaders, including deans, CEOs, and others. The survey generates broad but important findings for discussion and analysis in three areas: CME/CPD's structure, its function relative to relationships and educational methods, and its scope, reach, and impact. Throughout this report, data from the last Harrison Survey in 2013 are used for comparative purposes"--Executive summary.

Part 1. General Considerations -- 1. Global Burden of Surgical Disease and the Role of Academia -- 2. Promoting, Developing, and Sustaining Academic Global Surgery Programs.-3. Ethics in Global Surgery -- Part 2. Career -- 4. Preparing and Sustaining Your Career in Academic Global Surgery -- 5. Balancing Global Surgery with Traditional Career and Life Demands -- Part 3. Clinical -- 6. Guidelines and Parameters for Ideal Short-Term Interactions: Disaster Relief -- 7. How to Set Up for an Ideal Long Term Clinical Interaction -- Part 4. Research -- 8. Current Research Needs and Priorities -- 9. Research Methods Appropriate and Applicable to Global Surgery -- 10. Funding for Global Surgical Programs -- Part 5. Education -- 11. Developing Educational Opportunities for Trainees on Both Sides -- 12. The Role of Educational Research in the Global Setting -- Part 6. Resources -- 13. Tools Useful for the Academic Global Surgeon.

Part I. What You Should Know Before You Start -- 1. The Structure of Academic Careers -- 2. Hiring from the Institution's Point of View -- Part II. Planning and Timing Your Search -- 3. Becoming a Job Candidate: The Timetable for Your Search -- 4. Deciding Where and When to Apply -- 5. Building an Academic Network -- 6. Letters of Recommendation -- 7. Learning About Openings -- Part III. Written Materials for the Job Search: Suggestions and Samples -- 8. Responding to Position Announcements -- 9. CVs -- 10. Additional Application Materials -- 11. Online Presence -- 12. Job Hunting Correspondence -- IV. Conducting the Search -- 13. Interviewing -- 14. Preliminary Interviews -- 15. The Campus Visit -- 16. Job Offers, Negotiations, Acceptances, and Rejections -- Part V. After You Take the Job -- 17. Starting the Job -- 18. Knowing About and Getting Tenure -- 19. Changing Jobs -- Part VI. Additional Considerations -- 20. Dual-Career Couples and Pregnant on the Job Market -- 21. International Job Search -- 22. Cultural and Experiential Diversity -- Part VII. Beyond Faculty Careers -- 23. Exploring the Expanded Job Market -- Appendices -- Appendix 1: National Job Listing Sources and Scholarly and Professional Associations -- Appendix 2: Additional Resources -- Appendix 3: Sample Application Package -- Index -- Comments.

Attaining professional success and finding personal happiness in academic medicine is not an easy path, yet both are critical if the future is to be brighter through better science, better clinical care, better training, better responsiveness to communities, and better stewardship and leadership in the health professions. This concise, easy to read title consists of "mini" chapters intended as a resource to assist early- and middle-career physicians, clinicians, and scientists in understanding the unique mission of academic medicine and building creative, effective, and inspiring careers in a challenging field.

This comprehensive text is the definitive academic pain medicine resource for medical students, residents and fellows. Acting as both an introduction and continued reference for various levels of training, this guide provides practitioners with up-to-date academic standards. In order to comprehensively meet the need for such a contemporary text--treatment options, types of pain management, and variables affecting specific conditions are thoroughly examined across 48 chapters. Categories of pain conditions include orofacial, neuropathic, visceral, neck, acute, muscle and myofascial, chronic urogenital and pelvic, acute, and regional. Written by renowned experts in the field, each chapter is supplemented with high-quality color figures, tables and images that provide the reader with a fully immersive educational experience. Academic Pain Medicine: A Practical Guide to Rotations, Fellowship, and Beyond is an unprecedented contribution to the literature that addresses the wide-spread requisite for a practical guide to pain medicine within the academic environment.

This volume deals with philosophically grounded theories of animal generation as found in two different traditions: one, deriving primarily from Aristotelian natural philosophy and specifically from his Generation of Animals; and another, deriving from two related medical traditions, the Hippocratic and the Galenic. The book contains a classification and critique of works that touch on the history of embryology and animal generation written before 1980. It also contains translations of key sections of the works on which it is focused. It looks at two different scholarly communities: the physicians (medici) and philosophers (philosophi), that share a set of textual resources and philosophical lineages, as well as a shared problem (explaining animal generation), but that nevertheless have different concerns and commitments. The book demonstrates how those working in these two traditions not only shared a common philosophical background in the arts curricula of the universities, but were in constant intercourse with each other.0This book presents a test case of how scholarly communities differentiate themselves from each other through methods of argument, empirical investigation, and textual interpretations. It is all the more interesting because the two communities under investigation have so much in common and yet, in the end, are distinct in a number of important ways.

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

Plant improvement has shifted its focus from yield, quality and disease resistance to factors that will enhance commercial export, such as early maturity, shelf life and better processing quality. Conventional plant breeding methods aiming at the improvement of a self-pollinating crop, such as wheat, usually take 10-12 years to develop and release of the new variety. During the past 10 years, significant advances have been made and accelerated methods have been developed for precision breeding and early release of crop varieties. This work summarizes concepts dealing with germplasm enhancement and development of improved varieties based on innovative methodologies that include doubled haploidy, marker assisted selection, marker assisted background selection, genetic mapping, genomic selection, high-throughput genotyping, high-throughput phenotyping, mutation breeding, reverse breeding, transgenic breeding, shuttle breeding, speed breeding, low cost high-throughput field phenotyping, etc. It is an important reference with special focus on accelerated development of improved crop varieties.

1. Accelerated predictive stability: an introduction -- 2. Regulatory expectations and industry practice on stability testing -- 3. Theory and fundamentals of accelerated predictive stability (APS) studies -- 4. Practical considerations -- 5. The humidity exposure of packaged products -- 6. Data evaluation and statistical methods -- 7. Strategies for improving the reliability of accelerated predictive stability (APS) studies -- 8. Integration of APS into a rapid, early clinical drug product development paradigm -- 9. Accelerated predictive stability (APS) regulatory strategies -- 10. Embedding APS within business -- 11. Implementing an accelerated predictive stability program -- 12. Accelerated stability assessment program (ASAP) applications in a postapproval environment -- 13. ASAP application: unstable drug candidate in early development -- 14. ASAP application in suspension, liquid, lyophilized, and controlled-release drug products -- 15. Applications of ASAP to generic drugs -- 16. ASAP application: nicotine lozenges -- 17. ASAP applications in clinical development: prediction of degradation and dissolution performance -- 18. Accelerated predictive stability (APS) applications: packaging strategies for controlling dissolution performance -- 19. Accelerated stability modeling: investigation of disintegration time of a drug product with sodium bicarbonate -- 20. Accelerated stability modeling: an ionic liquid drug product -- 21. Accelerated stability modeling: assay loss of nicotine lozenges -- 22. Accelerated stability modeling: desolvation of a solvate drug product.

"Beyond simulation and algorithm development, many developers increasingly use MATLAB even for product deployment in computationally heavy fields. This often demands that MATLAB codes run faster by leveraging the distributed parallelism of Graphics Processing Units (GPUs). While MATLAB successfully provides high-level functions as a simulation tool for rapid prototyping, the underlying details and knowledge needed for utilizing GPUs make MATLAB users hesitate to step into it. Accelerating MATLAB with GPUs offers a primer on bridging this gap. Starting with the basics, setting up MATLAB for CUDA (in Windows, Linux and Mac OS X) and profiling, it then guides users through advanced topics such as CUDA libraries. The authors share their experience developing algorithms using MATLAB, C++ and GPUs for huge datasets, modifying MATLAB codes to better utilize the computational power of GPUs, and integrating them into commercial software products. Throughout the book, they demonstrate many example codes that can be used as templates of C-MEX and CUDA codes for readers' projects. Download example codes from the publisher's website: http://booksite.elsevier.com/9780124080805/ Shows how to accelerate MATLAB codes through the GPU for parallel processing, with minimal hardware knowledge -- Explains the related background on hardware, architecture and programming for ease of use -- Provides simple worked examples of MATLAB and CUDA C codes as well as templates that can be reused in real-world projects."--Provided by publisher.

Introduction to mindfulness and acceptance-based therapies for psychosis / Joseph E. Oliver, Candice Joseph, Majella Byrne, Louise C. Johns and Eric M.J. Morris -- Theory on voices / Fran Shawyer, Neil Thomas, Eric M.J. Morris and John Farhall -- Emotional processing and metacognitive awareness / Claire Hepworth, Helen Startup and Daniel Freeman -- Clinical assessment and assessment measures / John Farhall, Fran Shawyer, Neil Thomas and Eric M.J. Morris -- Acceptance and commitment therapy case formulation / Patty Bach -- Engaging people with psychosis in acceptance and commitment therapy and mindfulness / Brandon A. Gaudiano and Andrew M. Busch -- Acceptance and commitment therapy for voices / Neil Thomas, Eric M.J. Morris, Fran Shawyer and John Farhall -- Acceptance and commitment therapy for delusions / José Manuel García Montes, Marino Pérez Álvarez and Salvador Perona Garcelán -- Acceptance and commitment therapy for emotional dysfunction following psychosis / Ross White -- Person-based cognitive therapy for distressing psychosis / Lyn Ellett -- Spirituality: a new way into understanding psychosis / Isabel Clarke -- The service user experience of acceptance and commitment therapy and person-based cognitive therapy / Joseph E. Oliver, Mark Hayward, Helena B. McGuiness -- Acceptance and commitment therapy for first-episode psychosis / Joseph E. Oliver and Eric M.J. Morris -- Acceptance and commitment therapy for psychosis in acute psychiatric admission settings / Gordon Mitchell and Amy McArthur -- Developing acceptance and commitment therapy for psychosis as a group-based intervention / Amy McArthur, Gordon Mitchell and Louise C. Johns -- Group person-based cognitive therapy for distressing psychosis / Clara Strauss and Mark Hayward -- Appendix A: chessboard metaphor -- Appendix B: leaves-on-the-stream metaphor -- Appendix C: passengers-on-the-bus metaphor -- Appendix D: person-in-the-hole metaphor -- Appendix E: polygraph metaphor -- Appendix F: see the wood for the trees (and other helpful advice for living life) -- Appendix G: skiing metaphor -- Appendix H: tug-of-war-with-the-monster metaphor.

The history of the treatment of mental illness -- Acceptance and the recovery paradigm in mental health care -- The multiple dimensions of the acceptance of mental illness -- Barriers and facilitators to acceptance of mental illness -- The process of acceptance of mental illness -- Acceptance of mental illness among women : intersectional stigma -- Acceptance of mental illness among men : exploring masculinities and mental health -- Racial-ethnic cultural factors in the process of acceptance of mental illness -- LGBT factors in the process of acceptance of mental illness -- Clinical applications and investigation of the acceptance of mental illness.

"The use of venous access devices (VADs) is central to the care that nurses provide to patients with cancer. Oncology nurses must base their practice on evidence-based research when available, but a lack of evidence has been a professional challenge for decades. With limited research to guide practice, ongoing controversies remain regarding optimal device management. Since 1989, the Oncology Nursing Society (ONS) has provided guidelines to establish a foundation for access device management. With this new text, ONS has identified practice standards, developed from a synthesis of evidence, critical review, and analysis of aspects of access device management for which nursing is accountable. Access Device Standards of Practice for Oncology Nursing reviews the controversies in access device care, explores the range of devices currently available, details the advantages and disadvantages of each device to ensure optimal selection based on patient needs, and discusses the key legal ramifications concerning access devices and their management. With access device technology becoming more complex, this text is an essential resource for nurses practicing in a wide range of settings to ensure safe, effective care of patients with VADs."--Publisher's description.

This salient volume surveys the state of access to primary care and preventive health services by migrants, refugees, and asylum seekers across Europe. Experts in public health and allied fields identify obstacles to healthcare interventions for migrants, including costs, legal status, health-related behaviors and beliefs, and cultural and language barriers. The book includes the latest data concerning access to specific preventive services (e.g., vaccinations, colorectal screenings), specific issues of women and sexual minorities, and the potential for health promotion in prevention. Best practices for improving access are outlined as a basis for public health and policy directives toward reducing health disparities between migrant and native populations. Among the topics covered: Access to medical examination for prevention among migrants Access and barriers to infant vaccinations, female cancer screening and colorectal screening among migrant populations Provision and policy gap between the primary and preventive care required by and the care provided to LGBTQ+ migrants, refugees, and asylum seekers. Health related lifestyles and intermediate health conditions of migrants. Quality of primary healthcare and preventive health services provided to migrants Adaptations of primary health care for migrants Access to primary health care and policies on migration and health at a time of economic crisis Dedicated to bridging research and policy gaps in this vital area, Primary Care Access and Preventive Health Services of Migrants is intended for an international audience of academics, researchers, policymakers, and practitioners in public health and related disciplines. -- Publisher description.

"AccessDermatologyDxRx is a comprehensive resource for all physicians and other healthcare providers including medical students, dermatology residents, internists, oncologists, and infectious disease specialists. With thousands of images that include all of the essential information to help you with clinical decision-making, this resource covers the full scope of dermatologic conditions."--Website.

Clinical cases selected from the LANGE Case Files series, edited by Eugene C. Toy, MD.

"AccessPediatrics from McGraw-Hill Medical covers the entire span of pediatric practice, from neonatology through adolescent medicine. Updated regularly and optimized for viewing on any device, this comprehensive online pediatric resource provides instant access to information essential for completing evaluation, diagnosis, and case management decisions, as well as for pursuing research or self-assessment and board review -- all in one place."--Website.

"AccessPediatrics from McGraw-Hill Medical covers the entire span of pediatric practice, from neonatology through adolescent medicine. Updated regularly and optimized for viewing on any device, this comprehensive online pediatric resource provides instant access to information essential for completing evaluation, diagnosis, and case management decisions, as well as for pursuing research or self-assessment and board review -- all in one place."--Website.

Interactive self-assessment section of AccessSurgery website. Allows users to create and take custom tests based on standard review texts.

Since it was first published, Accident and Emergency Radiology: A Survival Guide has become the classic in-my-pocket-reference and an indispensable aid to all those who work in the Emergency Department. The core and substantial value lies in the step-by-step analytical approaches which help you to answer this question: "These images look normal to me, but . . . how can I be sure that I am not missing a subtle but important abnormality?" Ensure accuracy in reading and interpretation of any given image. Common sources of error and diagnostic difficulty are highlighted. Prevent mistakes. Pitfalls and associated abnormalities are emphasized throughout. Avoid misdiagnoses. Normal anatomy is outlined alongside schemes for detecting variants of the norm. Each chapter concludes with a summary of key points. Will provide a useful overview of the most important features in diagnosis and interpretation.Easily grasp difficult anatomical concepts. Radiographs accompanied by clear, explanatory line-drawings.

This book provides a state-of-the-art look at the applied biomechanics of accidental injury and prevention. The editors, Drs. Narayan Yoganandan, Alan M. Nahum and John W. Melvin are recognized international leaders and researchers in injury biomechanics, prevention and trauma medicine. They have assembled renowned researchers as authors for 29 chapters to cover individual aspects of human injury assessment and prevention. This third edition is thoroughly revised and expanded with new chapters in different fields. Topics covered address automotive, aviation, military and other environments. Field data collection; injury coding/scaling; injury epidemiology; mechanisms of injury; human tolerance to injury; simulations using experimental, complex computational models (finite element modeling) and statistical processes; anthropomorphic test device design, development and validation for crashworthiness applications in topics cited above; and current regulations are covered. Risk functions and injury criteria for various body regions are included. Adult and pediatric populations are addressed. The exhaustive list of references in many areas along with the latest developments is valuable to all those involved or intend to pursue this important topic on human injury biomechanics and prevention. The expanded edition will interest a variety of scholars and professionals including physicians, biomedical researchers in many disciplines, basic scientists, attorneys and jurists involved in accidental injury cases, and governmental bodies. It is hoped that this book will foster multidisciplinary collaborations by medical and engineering researchers, and academicians and practicing physicians for injury assessment and prevention and stimulate more applied research, education and training in the field of accidental-injury causation and prevention.

The predisposition to many diseases is strongly influenced by the genome of an individual. However, the association between the genome and most diseases is not fully understood, so there is an ongoing effort to characterize these associations. One way to characterize disease-genome associations is by studying the familial and ancestral origin of individuals in the context of disease. This kind of study relies on the fact that individuals with shared origins tend to have genomes and phenotypes that are similar to one another. Detailed information regarding familial and ancestral origin is often unknown, however, it can be inferred computationally by examining the genome. Therefore, it is important that we have accurate methods to infer this information in order to facilitate disease-genome associations. In this dissertation, I describe the contributions I have made to accurately inferring the ancestry and relatedness of individuals based on their genomes. First, I describe my work on ALLOY, a method to infer the ancestral origin of segments of the genome based on a factorial HMM. Next, I present PARENTE, a method to infer which individuals in a group are related to one another by detecting genomic segments that are identical-by-descent (IBD) using an embedded likelihood ratio test. Finally, I present PARENTE2, an extension of PARENTE that incorporates linkage disequilibrium information and results in significantly higher accuracy.

This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewing the evidence and providing a rationale for the appropriate use of RAS antagonists in cardiovascular diseases. It is written in an easy-to-follow format and with many illustrations to aid clarity and the assimilation of information. Each chapter is written by established authorities in their fields who are also experienced in explaining often complex concepts. The result is a unique book which is not only comprehensive but also clear and useful for the busy medical practitioner.

Surgical anatomy / Norbert Peter Tesch, Axel Gänsslen, Friedrich Anderhuber, Wolfgang Grechenig, and Stephan Grechenig -- Biomechanics / Axel Gänsslen, Michael Nerlich, and Stephan Grechenig -- Radiological diagnostics / Axel Gänsslen and Stephan Grechenig -- Classification of acetabulum fractures / Axel Gänsslen, Stephan Grechenig, and Michael Nerlich -- Epidemiology / Paul Schmitz, Axel Gänsslen, and Florian Baumann -- Indications and planning / Michael Müller, Daniel Popp, Axel Gänsslen, and Matej Cimerman -- Approaches / Axel Gänsslen, Stephan Grechenig, Norbert Peter Tesch, Friedrich Anderhuber, Wolfgang Grechenig, Hans-Gunther Clement, and Jan Lindahl -- Posterior wall fractures / Axel Gänsslen, Arne Berner, Michael Nerlich, and Mario Staresinic -- Posterior column fractures / Axel Gänsslen, Stephan Grechenig, Michael Nerlich, and Bore Bakota -- Associated posterior column and posterior wall fractures / Veronika Matzi, Axel Gänsslen, and Michael Nerlich -- Anterior wall fractures / Gloria Hohenberger, Axel Gänsslen, Paul Schmitz, Daniel Popp, and Jan Lindahl -- Anterior column fractures / Axel Gänsslen, Paul Schmitz, and Michael Nerlich -- Associated anterior column plus posterior hemitransverse fractures / Michael Müller, Axel Gänsslen, and Michael Nerlich -- Pure transverse fractures / Axel Gänsslen, Michael Mueller, and Michael Nerlich -- Transverse plus posterior wall fractures / Michael Müller, Axel Gänsslen, and Michael Nerlich -- T-type fractures / Axel Gänsslen, Michael Müller, and Michael Nerlich -- Both-column fractures / Axel Gänsslen, Thomas Dienstknecht, Michael Nerlich, and Jan Lindahl -- Fractures in the elderly / Florian Baumann, Paul Schmitz, Michael Müller, and Axel Gänsslen -- Acetabular fractures in children / Axel Gänsslen and Florian Baumann -- Heterotopic ossifications / Axel Gänsslen, Johannes Weber, and Michael Müller -- Thromboembolic complications / Axel Gänsslen, Johannes Weber, and Michael Müller -- Special screws and views / Axel Gänsslen, Frank Hildebrand, Markus Klebingat, Michael Nerlich, and Jan Lindahl -- Outcome scoring / Christian G. Pfeifer, Arne Berner, Michael Müller, and Axel Gänsslen -- Femoral head fractures : Pipkin IV / Axel Gänsslen and Stephan Grechenig -- Periprosthetic acetabular fractures / Axel Gänsslen, Paul Schmitz, and Frank Hildebrand.

Practical actions for healthcare providers / Val Moore -- Identifying a high quality evidence base / Paul Chrisp and Sara Twaddle -- Key challenges to implementation and effective interventions / Elaine Whitby and Julie Royce -- Using financial systems to support improved care / Jennifer Field -- Using measurement to support change and improvements in healthcare / Nick Baillie -- Conclusion and reflections / Danny Keenan and Sasha Abraham.

"The idea of person-centred health systems is widely advocated in political and policy declarations to better address health system challenges. A person-centred approach is advocated on political, ethical and instrumental grounds and believed to benefit service users, health professionals and the health system more broadly. However, there is continuing debate about the strategies that are available and effective to promote and implement 'personcentred' approaches. This book brings together the world's leading experts in the field to present the evidence base and analyse current challenges and issues. It examines 'person-centredness' from the different roles people take in health systems, as individual service users, care managers, taxpayers or active citizens. The evidence presented will not only provide invaluable policy advice to practitioners and policymakers working on the design and implementation of person-centred health systems but will also be an excellent resource for academics and graduate students researching health systems in Europe"-- Provided by publisher.

This publication offers a systemic analysis of sustainability in the food system, taking as its framework the Sustainable Development Goals of the 2030 Agenda of the United Nations. Targeted chapters from experts in the field cover main challenges in the food system and propose methods for achieving long term sustainability. Authors focus on how sustainability can be achieved along the whole food chain and in different contexts. Timely issues such as food security, climate change and migration and sustainable agriculture are discussed in depth. The volume is unique in its multidisciplinary and multi-stakeholder approach. Chapter authors come from a variety of backgrounds, and authors include academic professors, members of CSO and other international organizations, and policy makers. This plurality allows for a nuanced analysis of sustainability goals and practices from a variety of perspectives, making the book useful to a wide range of readers working in different areas related to sustainability and food production. The book is targeted towards the academic community and practitioners in the policy, international cooperation, nutrition, geography, and social sciences fields. Professors teaching in nutrition, food technology, food sociology, geography, global economics, food systems, agriculture and agronomy, and political science and international cooperation may find this to be a useful supplemental text in their courses.

v. 1. Biographie -- v. 2. Bibliographie -- v. 3. Briefwechsel

This book provides a concise yet comprehensive overview of acid-base disorders. Each chapter reviews an acid-base disorder, covering pathophysiology, evaluation, and management of the disorder. The chapters include clinical cases and a Q & A section, based on scenarios and questions that clinicians regularly encounter when treating patients with these disorders. The book concludes with two chapters on acid-based disorders in special patient populations, including critically ill patients, pregnant patients, and surgical patients. Written by an expert in the field, Acid-Base Disorders: Clinical Evaluation and Management is a state-of-the-art resource that should assist clinicians and practitioners in managing patients with acid-base disorders.

"The ACL-Deficient Knee: A Problem Solving Approach, focuses on problem analysis and problem solving, as well as analyzing the possibility of prevention. In each chapter, the biomechanics, anatomy, etc. that are relevant to the topic are reviewed. There are chapters where highly specialized surgical techniques are presented (v. gr. double bundle reconstruction or meniscal transplant), as well as developing areas such as ACL tears in children, where we are finding a growing number of injuries due to the increase of sports at early ages."--publisher's website

This book examines the short- and long-term impact of ACL injuries, covering training programs shown to reduce the rate of injuries in female athletes, and post-surgical rehabilitation for reducing the risk of future injury. Includes many color illustrations.

Part I. Anatomy and Histology of the ACL -- Chapter 1. Functional Anatomy of the ACL Fibers on the Femoral Attachment -- Chapter 2. The Anatomical Features of ACL Insertion Sites and Their Implications for Multi-Bundle Reconstruction -- Chapter 3. Discrepancy Between Macroscopic and Histological Observations -- Chapter 4. Tibial Insertion of the ACL: 3D-CT Images, Macroscopic, and Microscopic Findings -- Chapter 5. Mechanoreceptors in the ACL -- Part II. Biomechanics of the ACL -- Chapter 6. Mechanical Properties and Biomechanical Function of the ACL -- Chapter 7. Biomechanics of the Knee with Isolated One Bundle Tear of the Anterior Cruciate Ligament -- Chapter 8. Function and Biomechanics of ACL Remnant -- Chapter 9. Biomechanics of Single- and Double-Bundle ACL Reconstruction -- Chapter 10. ACL Injury Mechanisms -- Part III. Diagnostics of ACL Injury -- Chapter 11. Physical Examinations and Device Measurements for ACL Deficiency -- Chapter 12. Diagnostics of ACL Injury Using Magnetic Resonance Imaging (MRI) -- Chapter 13. Diagnosis of Injured ACL Using Three-Dimensional Computed Tomography: Usefulness for Preoperative Decision Making -- Part IV. Basic Knowledge of ACL Reconstruction -- Chapter 14. Graft Selection -- Chapter 15. Portal Placement -- Chapter 16. Femoral Bone Tunnel Placement -- Chapter 17. Tibial Bone Tunnel Placement in Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendons -- Chapter 18. Tensioning and Fixation of the Graft -- Chapter 19. Tendon Regeneration after Harvest for ACL Reconstruction -- Chapter 20. Second-Look Arthroscopic Evaluation after ACL Reconstruction -- Chapter 21. Bone Tunnel Changes After ACL Reconstruction -- Chapter 22. Graft I impingement -- Chapter 23. Fixation Procedure -- Part V Multiple bundle ACL Reconstruction -- Chapter 24. Single- vs. Double-Bundle ACL Reconstruction -- Chapter 25. Anatomic Double-Bundle Reconstruction Procedure -- Chapter 26. Triple-Bundle ACL Reconstruction with the Semitendinosus Tendon Graft -- Part VI. ACL Augmentation -- Chapter 27. History and Advantages of ACL Augmentation -- Chapter 28. Surgical Technique of ACL Augmentation -- Part VII. ACL Reconstruction Using Bone-Patella Tendon-Bone -- Chapter 29. An Overview -- Chapter 30. Anatomical Rectangular Tunnel ACL Reconstruction with a Bone-Patellar Tendon-Bone Graft -- Chapter 31. Rectangular vs. Round Tunnel -- Part VIII. Computer-Assisted Navigation in ACL Reconstruction -- Chapter 32. Intraoperative Biomechanical Evaluation Using a Navigation System -- Chapter 33. Application of Computer-Assisted Navigation -- Part IV. ACL Injury in Patients with Open Physes -- Chapter 34. ACL Reconstruction with Open Physes -- Chapter 35. Avulsion Fracture of the ACL -- Part V. Revision ACL Reconstruction -- Chapter 36. Double-Bundle Technique -- Chapter 37. Bone-Patellar Tendon-Bone Graft via Round Tunnel -- Chapter 38. Anatomical Revision ACL Reconstruction with Rectangular Tunnel Technique -- Chapter 39. One- vs. Two-Stage Revision Anterior Cruciate Ligament Reconstruction -- Part VI. Complications of ACL Reconstruction -- Chapter 40. Complications of ACL Reconstruction -- Part VII. Future of ACL Reconstruction -- Chapter 41. Future Challenges of Anterior Cruciate Ligament Reconstruction: Biological Modulation Using a Growth Factor Application for Enhancement of Graft Healing -- Chapter 42. Strategies to Enhance Biological Tendon-Bobe Healing in Anterior Cruciate Ligament Reconstruction -- Chapter 43. Tissue engineering approach for ACL healing.

Part 1: Overview of ACLS. Introduction ; Systems of care ; Systematic approach -- Part 2: Preventing arrest. Recognition: signs of clinical deterioration ; Acute coronary syndromes ; Acute stroke ; Bradycardia ; Tachycardia: stable and unstable -- Part 3: High-performance teams. High-performance team roles and dynamics ; Respiratory arrest ; Cardiac arrest: VF/pVT ; Cardiac arrest: PEA and asystole ; Cardiac arrest: selected special situations ; Post-cardiac arrest care -- Appendices: Testing checklists and learning station checklists ; ACLS pharmacology summary table ; Science summary table ; Glossary.

This book brings together world-famous acne researchers and specialists to compile a source of comprehensive, state-of-the-art information for management of acne. It examines acne as a chronic skin disease from pathogenesis to treatment. The book covers the clinical aspects of acne, topical treatments, light therapies, environmental factors and more alongside real patient photos from around the world. Treatments that chapters explore include photodynamic therapy and topical retinoids. In addition to genetic and hormonal causes of acne, chapters also include discussions on the connections between acne and diet, and acne and environmental factors. International contributors make this text unique in that it can focus solely on acne but also include international factors. Throughout the text, authors present the most up-to-date knowledge of acne pathophysiology, clinical features, differential diagnosis, treatment, and more. Pathophysiology, in particular, includes information on bacteria, immunity, endocrinologic factors, various deteriorating factors and environmental factors. As for clinical features, adult acne, differences in clinical patterns by region and race, and acne fulminans are covered. Regarding treatment, the latest knowledge on existing treatments or treatment methods, new drugs, and core outcome measures are mentioned. Acne: Current Concepts and Management is written for the dermatologist community from resident to researcher to privately practicing clinician.

Dermatologists commonly treat acne, which affects 40 to 50 million Americans each year and about 85 percent of all patients at some point in their lives. Dermatologists, primary care doctors, and pediatricians see these patients every day in practice. It is important to treat the skin effectively not only to reduce the risk of physical scarring, but also to address the negative psychosocial impact this disease carries. Improving the skin can improve self-confidence, interpersonal relationships, and performance in school or at work. Acneiform Eruptions in Dermatology is a practical, full-color guide to the differential diagnosis of acne vulgaris and the treatment of acne-like conditions. It is organized into sections by subtype of condition (e.g., infections, genetic syndromes, medication-caused) and includes a section of variants of acne that may be misdiagnosed. Within the sections, individual chapters discuss each variant of the condition and begin with a helpful bulleted summary of its defining clinical features. Extensive color clinical images appear throughout the book.

Foreword -- Introduction -- Part I Diagnosis of acquired myopathies -- Auto-Antibodies in Neuromuscular Disorders -- Electromyography -- Imaging of the Muscle -- Peripheral Nerve Ultrasound -- Magnetic Resonance Imaging of the Peripheral Nerve -- Part II Clinical Entities -- The Spectrum of Inflammatory Myopathies: Dermatomyositis, Polymyositis, Necrotizing Myositis and Inclusion Body Myositis -- Necrotising Myopathy -- Statin Myopathy -- Myasthenia Gravis -- Acquired Autoimmune Rippling Muscles with Myasthenia Gravis -- Endocrinological Myopathies -- Vitamin D deficiency in Muscle -- Intensive Care Unit Acquired Weakness -- Part III Neurogenic disorders -- Idiopathic Chronic Immune-Mediated Neuropathies: Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy -- GBS Immune Neuropathies -- Amyotrophic Lateral Sclerosis -- Epidemiology and Risk Factors -- Paraneoplastic Diseases of the Peripheral Nervous System -- Diabetic Neuropathy -- Infectious Neuropathies -- Toxic Neuropathies.

This book provides a state-of-the-art overview of the pathogenesis, diagnosis, and treatment of a range of inflammatory, autoimmune, and idiopathic disorders. The opening section covers clinical tools with a particular focus on the role of electromyography and MRI imaging. The second section then presents the differential diagnosis of acquired myopathies based on clinical, electrophysiological, muscle biopsy, and serological criteria, discussing in detail relevant clinical conditions such as including myasthenia gravis, polymyositis, and statin myopathies. The third section examines acute and chronic immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic diseases, and diabetic polyneuropathy, offering clear guidance on available treatments and descriptions of the latest advances in immunotheraphy, drug therapy, and physiotherapy. This clinically oriented book also includes numerous illustrative figures and contributions by international authors from leading centers.

Acquisition of Complex Arithmetic Skills and Higher-Order Mathematics Concepts focuses on typical and atypical learning of complex arithmetic skills and higher-order math concepts. As part of the series Mathematical Cognition and Learning, this volume covers recent advances in the understanding of children's developing competencies with whole-number arithmetic, fractions, and rational numbers. Each chapter covers these topics from multiple perspectives, including genetic disorders, cognition, instruction, and neural networks. Covers innovative measures and recent methodological advances in mathematical thinking and learning Contains contributions that improve instruction and education in these domains Informs policy aimed at increasing the level of mathematical proficiency in the general public.

1. History of Acrodermatitis Enteropathica -- 2. Epidemiology and Etiology -- 2.1. Epidemiology -- 2.2. Etiology -- 2.2.1. Molecular Etiology of AE -- 2.2.2. Hypothetical Etiology 1: the Alteration of Zinc Bioavailability -- 2.2.3. Hypothetical Etiology 2: a Defective Zinc Transporter -- 2.2.4. Alternative Forms of AE-like Zinc Deficiencies -- 3. Analysis of Disorder -- 3.1. Clinical Forms of AE -- 3.2. Nomenclature of Zinc Deficiencies -- 3.3. Acquired Non-hereditary Zinc Deficiency -- 3.3.1. Zinc Deficient Maternal Breast Milk -- 3.3.2. Zinc Deficient Caused by Metabolism Disorders -- 4. Clinical Symptoms -- 5. Diagnosis -- 5.1. Laboratory Diagnosis of Zinc Deficiency -- 5.2. Histopathology -- 5.3. Biological Diagnosis of AE -- 5.4. Clinical Diagnosis -- 5.5. Molecular Diagnosis -- 5.6. Differential Diagnosis -- 6. Disease Course and Treatment -- 6.1. Treatment -- 7. The Role of Zinc in Different Body Systems -- 7.1. Biochemistry of Zinc Metabolism -- 7.2. Skin and Hair Physiology -- 7.3. Gastrointestinal System and Other Organs -- 7.4. Neurological Development, Growth, and Mental Status -- 7.5. Enzymes -- 7.6. Endocrine System -- 7.7. Metabolism of Nucleic Acids -- 7.8. Mitosis and Meiosis Cycles -- 7.9. Cell Membranes -- 7.10. Synthesis of Proteins and Collagen -- 7.11. Immune System -- 8. History of AE in Adults -- 9. Iranian Hospital Cases in Literature -- 9.1. Patient One -- 9.2. Patient Two -- 9.3. Patient Three -- 9.4. Patient Four -- 9.5. Zinc Deficiency Similarities to AE in Infants (Fifth Patient) -- 10. Clinical Research -- 10.1. Abstract -- 10.2. Synopsis of Study -- 10.3. Purpose of Study -- 10.4. The Considered Hypotheses -- 10.5. Introduction -- 10.5. Methods -- 10.6. Ethical Considerations -- 10.7. Results -- 10.8. Discussion -- 11. Evaluation of Symptoms in Razi Dermatology Hospital -- 12. Case Photos.

Reviewing the most current literature, this text is a guide to medical decision-making regarding the diagnosis and treatment of patients with acromegaly. The scope of the book is comprehensive, covering all relevant facets of acromegaly, beginning with a history of the disorder and a review of the somatotrophic axis. Etiology is then discussed, including growth hormone secreting pituitary adenomas and other neuroendocrine tumors. Subsequent chapters present imaging modalities and diagnosis via radiology and clinical findings, as well as comorbid symptoms such as sleep apnea, musculoskeletal considerations, cardiovascular disorders, cancer and diabetes. Both medical and surgical management chapters describe each in detail, including radiotherapy, transsphenoidal surgery, somatostatin analogues and dopamine agonists. Concluding chapters present long-term follow-up as well as an extended selected patient story detailing life with the disease. Bringing together the latest in endocrinologic and neurosurgical evidence and practice, Acromegaly will be the go-to resource for this challenging condition for years to come. .

Intro; Preface; Contents; About the Editor; Abbreviations; 1: Actin Polymerization: A Cellular Perspective for Motility; 1.1 Introduction; 1.1.1 Cancer and Polycystic Ovarian Syndrome (PCOS); 1.1.2 Age-Related Neurodegenerative Disorders; 1.2 Actin: A Vital Player in Cell Motility; 1.2.1 Swimming: A Cellular Motility Phenomenon; 1.2.2 Actin-Driven Cellular Motility; 1.2.2.1 Directional Motility; 1.2.2.2 Cytokinesis; 1.2.2.3 Organelle Transport and Protein Trafficking; 1.3 Gliding Motility; 1.3.1 Gliding Motility in Apicomplexan; Bibliography 2: Actin: The Central Ubiquitous Player in the Phenomenon2.1 Introduction; 2.2 Sequence Analysis of the G-Actin; 2.3 Structure of G-Actin; 2.3.1 3D Structure of G-Actin; 2.3.1.1 Architecture of G-Actin; 2.3.1.2 Loops; 2.3.1.2.1 S-Loop (Residues 11-16) and G-Loop (Residues 154-161); 2.3.1.2.2 H-Loop (Residues70-78); 2.3.1.3 Dnase-Binding Loop (D-Loop, Residues 38-52); 2.3.1.4 Loop 60-69; 2.3.1.5 W-Loop (Residues 165-172); 2.3.1.6 Hydrophobic Plug (H-Plug) (Residues 264-273); 2.3.1.7 C-Terminal (Residues 349-375) and N-Terminal (Residues 1-10) Loops; 2.4 Role of Metal Ions 2.5 Conformational States of Actin2.6 Upsi-Phosphate Sensing; 2.7 Filamentous Actin (F-Actin); 2.7.1 Actin Polymerization; 2.8 Mechanism of Actin Polymerization; 2.9 Kinetics of Actin Polymerization; 2.10 Thermodynamics of Actin Polymerization; 2.11 Stability of Actin Filament; 2.12 Drugs Binding to Actin; Bibliography; 3: Formin: The Multidomain Elongator of Actin Polymer; 3.1 Introduction; 3.2 Localization; 3.3 Function; 3.4 Domain Organization; 3.4.1 Formin Homology-1 (FH1) Domain; 3.4.2 Formin Homology-2 (FH2) Domain; 3.4.3 Diaphanous Autoregulatory Domain (DAD) 3.4.4 Other Accessory Domains3.4.5 Domain-Isotype Relationship; Bibliography; 4: Profilin: The Associates of Formin; 4.1 Introduction; 4.2 Functions; 4.3 Structure; 4.4 Binding Partners of Profilin; 4.5 Poly-Proline-Binding Site; 4.6 Actin-Binding Sites; 4.7 Affinity of Profilin for Actin; 4.8 Hydrophobic Core; 4.9 Regulators of Profilin; Bibliography; 5: ADF (Actin Depolymerizing Factor): The Breaker of the Polymer in Homeostasis; 5.1 Introduction; 5.2 Isoforms of ADF; 5.3 Functions; 5.4 Structure; 5.5 Stability of ADF; 5.6 Regulators of ADF; 5.6.1 PIP2; 5.6.2 Phosphorylation; 5.6.3 pH

Epidemiology of actinic keratosis / Green, A.C -- Patients' perspectives on actinic keratosis / Esmann, S. -- Photodamage : all signs lead to actinic keratosis and early squamous cell cancer / Wei, J.; Kok, L.F.; Byrne, S.N.; Halliday, G.M. -- Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma / Joseph, S.R.; Munoz, L.; Gaffney, D.C.; Saunders, N.A.; Simpson, F. -- The actinic keratosis virome : can we prevent squamous cell carcinoma with a vaccine? / Frazer, I.H. -- Do actinic keratoses and superficial squamous cell carcinomas have a specific immunoprofile? / Wells, J.W. -- Mouse models for actinic keratosis and squamous cell carcinoma / Handoko, H.Y.; Ferguson, B.; Walker, G.J. -- Keratinocyte cancer and its precursors in organ transplant patients / Jenni, D.; Hofbauer, G.F.L. -- Clinical features of actinic keratoses and early squamous cell carcinoma / Wheller, L.; Soyer, P. -- The many clinico-pathologic faces of actinic keratosis : an atlas / Massone, C.; Cerroni, L. -- Dermoscopy of actinic keratosis, intraepidermal carcinoma and squamous cell carcinoma / Zalaudek, I.; Argenziano, G. -- The future of keratinocyte skin cancer surveillance : automated image analysis to identify and monitor keratinocyte dysplasia / Hames, S.C.; Prow, T.W. -- Reflectance confocal microscopy : hallmarks of keratinocyte cancer and its precursors / Prow, T.W.; Tan, J.-M.; Pellacani, G. -- Optical coherence tomography and its role for delineating the thickness of keratinocyte dysplasia and neoplasia / Themstrup, L.; Jemec, G.B.E. -- Teledermatology : its use in the detection and management of actinic keratosis / Janda, M. -- Conventional treatment of actinic keratosis : an overview / Peris, K.; Fargnoli, M.C. -- Field cancerization : from molecular basis to selective field-directed management of actinic keratosis / Philipp-Dormston, W.G. -- Update on photodynamic treatment for actinic keratosis / Wiegell, S.R. -- Laser treatment and its implications for photodamaged skin and actinic keratosis / de Vries, K.; Prens, E.P. -- Ingenol mebutate : from common weed to cancer cure / Zarchi, K.; Jemec, G.B.E. -- Oral nicotinamide and actinic keratosis : a supplement success story / Kim, B.; Halliday, G.M.; Damian, D.L.

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

The purpose of the The Active Female: Health Issues Throughout the Lifespan, 2nd Edition is twofold: (1) to increase the awareness of wellness and fitness issues for active females and their family members; and (2) to provide an avenue for medical practitioners, allied health professionals, health educators, and certified individuals in sports medicine to gain critical, updated knowledge of a field specific to active females. Part I of the book offers a foundation to help the reader understand the interrelationship among body image concerns, the female reproductive cycle, and musculoskeletal anatomy/physiology of females that makes their health risks and concerns unique. Reproductive health is discussed by a prominent researcher in reproduction/endocrinology. An overview of the Female Athlete Triad which is a syndrome of three interrelated conditions (isordered eating, menstrual disturbances and bone loss) is presented in Part II. Physicians and certified professionals in sports medicine discuss the individual components of the triad, relating not only to the athletic female but also to the recreationally active woman throughout the lifespan. In Part III, Prevention and management of common musculoskeletal injuries is addressed by a female orthopedic surgeon who sub-specializes in treating female athletes. Finally, appropriate exercise and nutritional guidelines for active females are discussed in Parts IV-V of the book by certified professionals and licensed physicians in sports medicine. An invaluable addition to the literature, The Active Female: Health Issues Throughout the Lifespan, 2nd Edition will be of great interest to physicians, allied health care practitioners, medical/other wellness educators, and students who are interested in advancing women's health issues. Sports medicine specialists, family practitioners, gynecologists, team physicians, residents in sports medicine, athletic trainers, health educators, nurses, physicians assistants, physical therapists, sport psychologists, counselors, athletic trainers, and other members of the sports medicine team should also find this title of significant interest.

"This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions."--Publisher's description.

This volume focuses on explorative activity-based proteomics, biomedical applications of activity-based proteomics, and chemical strategies in activity-based proteomics providing a concise overview of activity-based protein profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Activity-Based Proteomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.-- Source other than the Library of Congress.

I. L'énergie (points, méridiens, circulation) -- II. Le maniement de l'énergie.

This book systematically introduces the Brain in Traditional Chinese Medicine (TCM) and its acupuncture treatments. It discusses the origin and development of the TCM Brain theory, and presents current research on brain and acupuncture, the unique brain related techniques such as scalp acupuncture and Dao-qi technique, the new developing acupuncture treatment methods for brain-related conditions, such as stroke, Parkinson's, dementia, Alzheimer's disease, multiple sclerosis, traumatic brain injury, autism, cerebral palsy and depression, anxiety, bipolar disorder among others. This book is of interest to TCM and acupuncture practitioners in the West, as well as acupuncture researchers and lecturers. It gives a new understanding of the brain and treatments for brain-related conditions from a complementary medicine point of view.

Acupuncture for Pain Management is intended as the premier resource for learning the fundamentals of the art of medical acupuncture. Edited by top pain medicine specialists at Harvard and UCLA, and based on their popular annual workshop at the American Society for Anesthesiologists, the book is the perfect synthesis of Western and Chinese medicine. Anesthesiologists, pain medicine specialists, primary care physicians, osteopaths, neurologists, psychiatrists, physical medicine and rehabilitation specialists, and other health professionals looking to add acupuncture to their repertoire will benefit from the concise and practical approach of the book. Features: Each individual meridian discussed in detail acupuncture for 25 clinical conditions, including headache, menstrual pain, low back pain, insomnia, and more. Aimed at acupuncturists as well as practitioners who want to add acupuncture to their clinical armamentarium.

Section I: Foundations. Principles for practice development to facilitate outcomes and productivity -- Billing, reimbursement, and setting up a clinic -- Anatomy and physiology of skin and soft tissue -- Wound-healing physiology and factors that affect the repair process -- Types of skin damage and differential diagnosis -- Skin and wound inspection and assessment -- Section II: Pressure ulcers. Pressure ulcers: impact, etiology, and classification -- Developing and maintaining a pressure ulcer prevention program -- Support surfaces -- Section III: Lower extremity wounds. Lower extremity assessment -- Arterial ulcers -- Venous ulcers -- Lymphedema -- Neuropathic wounds: the diabetic wound -- Foot and nail care -- Section IV: Wound bed preparation. Wound infection: diagnosis and management -- Wound debridement -- Principles of wound healing and topical management -- Section V: Biophysical and biologic agents. Cellular- and/or tissue-based products for wounds -- Molecular and cellular regulators -- Negative pressure wound therapy -- Hyperbaric oxygenation -- Electrical stimulation -- Ultraviolet light and ultrasound -- Section VI: Critical cofactors. Wound pain: impact and assessment -- Managing wound pain -- Nutritional assessment and support -- Perfusion and oxygenation -- Eliminating noncompliance -- Section VII: Acute and traumatic wounds. Uncommon wounds and manifestations of intrinsic disease -- Traumatic wounds: bullets, blasts, and vehicle crashes -- Burns -- Reconstructive surgery -- Surgical wounds and incision care -- Section VIII: Special patient populations. Skin care needs of the obese patient -- Skin care needs of the neonatal and pediatric patient -- Managing wounds in palliative care -- Management of draining wounds and fistulas -- Percutaneous tube management -- Appendix A: Tool examples to support skin and wound care -- Appendix B: Self-assessment exercises.

Part I. Surgery -- 1. Acute Appendicitis -- 2. Acute Biliary Tract Diseases -- 3. Acute Pancreatitis -- 4. Nontraumatic Gastroduodenal Perforations -- 5. Symptomatic Abdominal Wall Hernias -- 6. Symptomatic Diaphragmatic Hernia -- 7. Intestinal Obstruction -- 8. Acute Inflammatory Bowel Disease -- 9. Spleen -- 10. Abdominal Trauma -- 11. Miscellaneous Conditions -- Part II. Gynecology -- 12. Adnexal Torsion -- 13. (Isolated) Torsion of the Fallopian Tube -- 14. Ruptured/Bleeding Ovarian Cysts/Tumors -- 15. Ruptured Ectopic Pregnancy -- 16. Spontaneous Uterine Rupture -- 17. Torsion of the Gravid Uterus -- 18. Degenerating Uterine Myomas -- 19. Pelvic Inflammatory Disease and Tubo-ovarian Abscess.

This book will help readers recognize, diagnose and efficiently treat acute abdominal disorders encountered in the pregnant patient, whether associated with or incidental to the pregnancy. Includes more than 200 figures relevant to diagnosis and treatment.

Neglected finger injuries may lead to chronic lesions that often have detrimental consequences for the practice of a ball sport, whether at a recreational level or at the top athlete level. The initial injury management is crucial. Depending on the type and the severity of the lesions, different people may get involved: the players themselves or their entourage, physiotherapists, club doctors, emergency physicians, family doctors, sports doctors or hand surgeons. Treatment is usually conservative: the long fingers require rapid mobilization to prevent stiffness and contrary to that, the thumb requires stability. Surgery may be necessary to reach these goals especially for athletes, because of the demands of their sport. Chronic lesions are also in part related to repeated trauma, requiring specialized long-term multidisciplinary treatment. They can often lead to the end of a sporting career, but also may limit the functionality of the fingers at the time of conversion.

This is a comprehensive practical guide to the practice of the new subspecialty of critical care echocardiography. The text covers all aspects of clinical practice and describes how to use transthoracic echocardiography to approach and manage common clinical questions. Specific emphasis is placed on the appropriate use of clinical echocardiographic data in the context of the patient's critical illness; this is illustrated by the frequent use of case studies including both still and moving echocardiographic images. The text covers assessment of, and disorders affecting, the left and right heart, including shock and sepsis. It also looks at how to interpret diastolic information during critical illness and the effect of that illness on valve disease and function. The important subject of fluid responsiveness is explored in detail, as is the influence of organ support and illness on the diagnosis of cardiac tamponade. The information given in the text is summarized using algorithms in a field guide for the critical care echocardiographer, which also provides a rapid guide to assessing time-critical patient presentations.

This pocket guide is a single-volume source of the most common and important formulas and laboratory values used in the daily practice of acute care and critical care medicine. Information is presented in outline format and as tables, graphics, and algorithms to facilitate quick look up. Acute and Critical Care Formulas and Laboratory Values is designed to help clinicians interpret clinical data, apply formulas, understand laboratory values, and integrate this information with their knowledge of pathophysiology to promote the delivery of evidence-based care. Essential formulas and laboratory values. Multiple ways to derive a value, where appropriate. Non-clinical formulas useful for understanding physiologic concepts or that underlie diagnostic tests or clinical measurement.

1. An Introduction to the Acute Care for Elders / Michael L. Malone, Ji Won Yoo, and James S. Goodwin -- 2. The Team Approach to Interdisciplinary Care / Maryjo Cleveland, Carolyn Holder, Ariba Khan, and Aileen Jencius -- 3. Patient and Hospital Factors That Lead to Adverse Outcomes in Hospitalized Elders / Edgar Pierluissi, Deborah C. Francis, and Kenneth E. Covinsky -- 4. An Overview of Hospital-Based Models of Care / Elizabeth A. Capezuti and Marie Boltz -- 5. The Acute Care for Elders Unit / Robert M. Palmer and Denise M. Kresevic -- 6. How to Develop, Start, and Sustain an Acute Care for Elders Unit / Ellen S. Danto-Nocton, Carolyn Holder, Rebecca Ramsden, Jonny Macias Tejada, Anita Steliga, and Karen Padua -- 7. How to Disseminate the ACE Model of Care Beyond One Unit / Roger Y. Wong, Marsha Vollbrecht, and Patti Pagel -- 8. How to Use the ACE Unit to Improve Hospital Safety and Quality for Older Patients: From ACE Units to Elder-Friendly Hospitals / Samir K. Sinha, Sandra Liliana Oakes, Selma Chaudhry, and Theodore T. Suh -- 9. ACE Unit Business Model / Kyle Allen, Peter DeGolia, Susan Hazelett, and Diane Powell -- 10. Models of Care to Transition from Hospital to Home / Ella Harvey Bowman, Kellie L. Flood, and Alicia I. Arbaje -- 11. What Is the Role of Hospitalists in the Acute Care for Elders? / Heidi L. Wald and Melissa L. P. Mattison -- 12. How to Improve Care for Seniors in the Emergency Department / Soryal Soryal, Marie Boltz, Scott Wilber, and Michael L. Malone -- 13. How to Improve Care for Older Patients in the Intensive Care Unit / Leanne Boehm, E. Wesley Ely, and Lorraine Mion -- 14. The Future of Acute Care for Elders / Kanwardeep Singh and Michael L. Malone.

Acute Care General Surgery provides a succinct focused overview of a myriad of general surgical emergencies. Each chapter has a concise, practical framework on the workup and management of a specific topic. The book covers a wide array of pathology from the more common appendicitis, diverticulitis and cholecystitis to those less frequently encountered such as toxic megacolon, Fournier's gangrene and volvulus. Learning objectives for each chapter are clearly defined. In addition to differential diagnosis, the work up and management is comprehensively discussed. In addition, a pithy clinical pearl is included to serve as a memory aid for each diagnosis. Upon reviewing this volume, clinicians who encounter the acute care surgical patient in their practices will be better equipped to rapidly assess, evaluate, diagnose and managing their complex and often challenging problems.

Part 1. Introduction -- 1. Acute Care Setting -- 2. The Medical Record -- Part 2. Body Systems -- 3. Cardiac System --4. Pulmonary System -- 5. Musculoskeletal System -- 6. Nervous System -- 7. Vascular System and Hematology -- 8. Gastrointestinal System -- 9. Genitourinary System -- 10. Endocrine System -- Part 3. Diagnoses -- 11. Oncology -- 12. Burns and Wounds -- 13. Infectious Diseases -- 14. Organ Transplantation -- 15. Fluid and Electrolyte Imbalances -- 16. Amputation -- 17. Physical Therapy Considerations for Patients Who Complain of Chest Pain -- Part 4. Interventions -- 18. Medical-Surgical Equipment in the Acute Care Setting -- 19. Pharmacologic Agents -- 20. Anesthesia: Perioperative Considerations for the Physical Therapist -- 21. Acute Pain Management -- 22. Postural Drainage -- 23. Functional Tests -- Appendix A. Preferred Practice Patterns.

This book reviews the common clinical scenarios that might trigger emergent consultation for neurosurgical intervention, with attention to key components of the clinical interview and exam, optimal diagnostic evaluation, indications for and the goals of operative intervention, perioperative considerations, and strategies for complication mitigation. This is not a surgical atlas, but rather, a road map for the journey to the operating room door. The intent is to establish a systematic, evidence-based action plan for the patient presenting in neurologic crisis. Each chapter opens with a relevant case vignette and then unfolds through uniform sections to tell the story of how one might approach the disease entity in question, from initial request for consultation to definitive management, highlighting steps of the decision-making process. Each chapter is punctuated by 3-5 teaching pearls, summarizing these key elements. The overall goal is to create a framework for assessment that might be applied in the emergency department, the trauma bay, or the ICU when a neurologic emergency arises. The scope encompasses not only cranial and spinal trauma, but also entities such as shunt failure, stroke, aneurysmal subarachnoid hemorrhage, pituitary apoplexy, cauda equina syndrome, and central nervous system infection that might require time-sensitive intervention. An additional section addresses issues requiring emergent neurosurgical response in the ICU setting, including sudden neurologic worsening, status epilepticus, and abnormal clotting/ coagulopathy. .

"Substantially updated with more illustrations and brand-new chapters that reflect the growth and advances in the field, this latest edition of Acute Care Surgery features an editorial board drawn from the ranks of trauma surgery, emergency surgery, and critical care surgery. A comprehensive, updated, and timely overview of this fledgling specialty!"--Provided by publisher.

Section I. Radiology basics -- Section II. Abdomen -- Section III. Chest -- Section IV. Soft tissue -- Section V. Trauma.

This pocket manual is a practically oriented, wide-ranging guide to acute care surgery general aspects and℗ℓto non-gastrointestinal emergencies. It covers the most common problems in thoracic, obstetric, gynecologic, anorectal, vascular and skin surgery and also includes chapters on postoperative complications in bariatric surgery, antibiotic management, nutrition and interventional radiology in acute care surgery. This guide stems from collaboration with the World Society of Emergency Surgery (WSES) and aims to provide general surgeons, ℗ℓresidents and trainees with a comprehensive and up-to-date overview℗ℓof the℗ℓmost relevant operative techniques and with useful℗ℓ "tips and tricks" applicable in daily clinical practice. A second volume on gastrointestinal and abdominal surgical emergencies is also available.

This volume focuses on acute trauma to the adult elbow, including fractures, dislocations, tendon ruptures, and vascular and nerve injuries. Each chapter addresses anatomical key features, surgical and conservative therapeutic procedures, postoperative regimes and complication strategies. International elbow experts explore a range of surgical approaches, the usage of modern implants, advances in surgical techniques, and pearls and pitfalls for each trauma entity. Moreover, the authors describe total elbow arthroplasty and radial head replacement in detail, outline current clinical outcomes, and provide recommendations for therapeutic approaches and salvage measures. The book enables the orthopedic surgeon to deal with the entire spectrum of acute simple and complex elbow injuries in adults.

Section I. Introduction -- Section II. Pathophysiology -- Section III. Diagnostic Strategy -- Section IV. Subtypes of Acute Encephalopathy -- Section V. Subtypes of Acute Encephalitis -- Section VI. Encephalopathy/Encephalitis With Refractory Epileptic Status: Rima Nabbout -- Section VII. Management of Acute Encephalopathy and Encephalitis.

This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology, state-of–the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF. The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end stage liver diseases than HBV induced ACLF. This volume 1 has 6 chapters and focuses on the definition, research technology, virology, genetics, and immunology.

Section 1: Basics -- 1. Pathophysiology of ischemic stroke -- 2. Pathophysiology of moyamoya disease -- 3. Radiological assessment of ischemic stroke -- 4. Pathology of blood clot -- Section 2: Medical Practices -- 5. General management & intensive care of ischemic stroke -- 6. Cardiac evaluation and management after ischemic cerebral stroke -- 7. Intravenous thrombolytic therapy -- 8. Pediatric ischemic stroke -- Section 3: Endovascular Practices -- 9. History and overview -- 10. Clot aspiration technique -- 11. Stent retriever technique -- 12. Intracranial stenting -- 13. Treatment of arterial dissection -- Section 4: Surgical Practices -- 14. Surgical embolectomy -- 15. Bypass surgery -- 16. Decompressive hemicraniectomy.

Acute kidney injury epidemiology : from recognition to intervention / Wang, Y., Fang, Y., Teng, J., Ding, X. -- Acute kidney injury prevention / Chopra, T.A., Brooks, C.H., Okusa, M.D. -- Renal recovery after acute kidney injury / Macedo, E., Mehta, R.L. -- Pathophysiology of septic acute kidney injury / Mårtensson, J., Bellomo, R. -- Biomarkers for diagnosis, prognosis and intervention in acute kidney injury / Fuhrman, D.Y., Kellum, J.A. -- The acute kidney injury to chronic kidney disease transition : a potential opportunity to improve care in acute kidney injury / Palant, C., Amdur, R., Chawla, L.S. -- Electronic data systems and acute kidney injury / Cheungpasitporn, W., Kashani, K. -- Fluid management in acute kidney injury / Chuang, C.-L. -- Multidimensional approach to adequacy of renal replacement therapy in acute kidney injury / Villa, G., Ricci, Z., Romagnoli, S., Ronco, C. -- Timing of renal replacement therapy in acute kidney injury / Ostermann, M., Wald, R., Bagshaw, S.M. -- Pediatric continuous renal replacement therapy / Ricci, Z., Goldstein, S.L. -- Management of cardiac surgery-associated acute kidney injury / Ding, X., Xu, J., Jiang, W., Fang, Y., Teng, J.

This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis. Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

The new edition of this well-received book provides a timely update of current knowledge on the biology, disease classification, and treatment of the acute leukemias - acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Throughout, the focus is on the provision of state of the art information and guidance that will meet the needs of clinicians. Chapters have been extensively revised to take into account advances in understanding and management that have been achieved over the past few years. In addition, new chapters have been included on selection of AML patients for therapy, a broader discussion of stem cell transplantation in AML, the role of immunotherapy in ALL, the approach to newly diagnosed pediatric ALL, and the diagnosis and management of BCR-ABL-like ALL. New therapies, including investigational ones, are fully covered. As progress continues in the management of acute leukemias this book will be a valuable asset for clinicians at all levels of experience.

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ​

Emergency General Surgery has become a cornerstone of Acute Care Surgery over the past decade. Once the scope of community general surgeons, the growing complexity of patients with acute surgical diseases has increasingly driven their care to tertiary referral centers. The aging population confounds this problem further as these patients present with more complex comorbidities, life-threatening physiology, and progressively severe anatomic disease severity. To ensure better outcomes, the practice has evolved to focus on evidence-based practice management guidelines in order to standardize care and optimize outcomes. This text provides a comprehensive volume for any surgeon who treats patients with acute surgical diseases. The first section is a comprehensive analysis of the background of Emergency General Surgery. The goal of this section is to provide the reader background into the acute surgical practice and to introduce the reader to the important concepts discussed in the remainder of the text. The second section discuss specific acute surgical diseases. Individual chapters outline the diagnostic approach, current treatment standards, operative approaches, and expected outcomes with an emphasis on practice management guideline implementation into practice. As acute surgical diseases and surgical critical care are integral to each other, the last section will be Critical Care for the Acute Care Surgeon. These topics focus on the critical care concepts essential to surgeons who care for acute diseases. This comprehensive text is targeted to any surgeon who takes emergency calls for any of the listed diseases including community and referral general and vascular surgeons. In addition, this would be an excellent resource for all general surgery residents. Lastly, this would also serve as a resource to intensivists who care for acute surgical patients.

"Acute Medicine offers an accessible and concise guide to the practical management of all acute medical problems likely to be encountered in the emergency department, ambulatory care centre, acute medical unit or on the wards. Reflecting the maturation of acute medicine as a separate specialty, the book is divided into common presentations, specific problems and procedures. New to the fifth edition is a chapter on bed-side ultrasonography; throughout, emphasis is placed on patient safety, and the use of flow diagrams, tables and figures ensures that key information is quickly accessible. Thoroughly revised by experts in the subject, and updated to reflect current approaches to diagnosis and management, Acute Medicine is an excellent companion for the trainee as well as an aide-mm̌oire for the more experienced physician"--Provided by publisher.

This book, written by a team of leading experts, provides a comprehensive overview of acute myeloid leukemia (AML), the most frequent acute leukemia in adults. The opening chapters present current knowledge of epidemiology, etiologic factors, and the pathogenesis and molecular development of AML. Detailed guidance is offered on laboratory and clinical diagnostic workup and disease classification, and the patient- and disease-related factors that determine prognosis and treatment allocation are identified. On the basis of these general considerations, initial treatments in patients considered fit for intensive treatment and in older and co-morbid patients are reviewed, and the available relapse treatment strategies, explained. For all clinical scenarios, the most recent data on the optimal use of newly approved agents in different AML subgroups are presented. Separate chapters address the treatment of acute promyelocytic leukemia, current practice of allogeneic stem cell transplantation, and special clinical situations. Finally, promising approaches in drug development, current standards and challenges in assessment of measurable residual disease, immune approaches, and ideas for innovative trial designs are considered.

This volume describes up-to-date techniques used in understanding the molecular biology of acute myeloid leukemia (AML) and addressing advances in diagnosis, classification, prognostication, and therapeutic strategies to potentially impact overall patient survival. The chapters in this book cover topics such as: cytochemical staining, single-cell mass cytometry of AML and Leukemia stem/progenitor cells, microsphere-based assessment of DNA methylation for AML prognosis, a zebrafish model for evaluating the function of human leukemic gene IDH1 and its mutation, and the isolation of biologically active exosomes from plasma of patients with cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Acute Myeloid Leukemia: Methods and Protocols is a valuable resource for scientists and researchers to further their studies and advancements in the field of AML.

This practical guide provides the reader with answers to important clinically relevant questions regarding the evaluation and management of acute kidney injury (AKI). All aspects of critical care nephrology are covered, from pathophysiology and diagnosis to prevention and treatment. The questions considered relate to a wide range of issues, such as: How do I diagnose AKI? How can I protect the kidney in clinical practice? How do I manage patients with AKI? When should I initiate and how do I perform renal replacement therapy (RTT)? Which type of RTT is most appropriate for my patient? Should I give specific nutrients? In addition to providing practical guidelines and treatment algorithms, the book includes calculators for continuous RRT and anticoagulant dosing. The authors are internationally renowned experts in the fields of Intensive Care Medicine and Nephrology, and all contributions are written in a clear and concise style and have been peer reviewed. Acute Nephrology for the Critical Care Physician will serve as a very useful source for intensivists, internists, anesthesiologists, and nephrologists involved in the management and treatment of critically ill patients at risk of or affected by AKI.

The book provides detailed information on all major neuroemergencies, and includes a detailed checklist for practical care during the first hour of an emergency. Reinforcing the concept of quality care for better outcomes in patients with neurological diseases, the book discusses approaches to comatose patients, neurological evaluation, neuropharmacology, neuroradiology, traumatic brain and spine injury, and various other neurological disorders. The field of neuroanesthesiology and neurocritical care has expanded with the advent of newer, complex surgeries, and neurocritical care is becoming an established subspecialty of neuroscience. Neurological emergencies require special care since prevention of secondary damage to the brain is of paramount importance. A valuable resource for intensivists, neurointensivists, emergency medicine physicians, neurology and neurosurgeons and nursing professionals involved in neurocare, this book also serves as study material for participants of the two-day course on "Acute Neuro Care" designed by the Indian Society of Neuroanesthesiology and Critical Care (ISNACC).

This practical guide for trainees and advanced practice providers covers the essential management of hospitalized patients with acute neurologic conditions. Divided into five sections, this text serves as an incredibly easy-to-use, visually accessible, how-to manual that covers exactly what every responding clinician needs to know to care for the patient in front of them. The first section provides tangible guidance about how to pre-round, structure a presentation, examine neurologically ill patients, and interpret the core diagnostics obtained in many neurology patients: CT, MRI and EEG. The next three sections cover common complaints encountered in the hospital: spanning from non-vascular admissions, vascular & stroke neurology topics, and core neurocritical care principals and chief complaints. Throughout are checklists, scoring systems, pro-tips, images, helpful reminders, as well as concise summary of the pertinent literature. This is an ideal guide for medical students, neurology & neurosurgery trainees and advanced practice providers, as well as experienced professionals who want to brush up on the latest updates.

This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.

This book provides recommendations for evaluation and therapy in the area of acute pediatric neurology; these are presented didactically with frequent use of illustrations and algorithms. Chapters in the first part of the book discuss presenting symptoms of acute neurological conditions. The second part of the book covers major areas of acute pediatric neurology and each of these chapters has three key elements: description of presenting symptoms; recommended assessments; and recommended interventions. Acute Pediatric Neurology provides an accessible, clinically focused guide to assist physicians in the emergency ward or intensive care unit in decisions on diagnosis and therapeutic interventions in all major acute pediatric neurological diseases.

History of APL -- Molecular Targets of Treatment in APL -- The Leukemic Stem Cell -- The Molecular Genetics of APL -- APL Coagulopathy -- Early Death in APL -- Prognostic Factors in APL -- First-line therapy for APL: Chemotherapy-based approach -- First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach -- Cure of APL without Chemotherapy -- Minimal Residual Disease in APL -- Treatment of refractory and relapsed APL -- Hematopoietic Stem Cell Transplantation in APL -- APL in Children -- Management of APL in the Elderly -- Special Situations in APL -- APL in Developing Countries: A Chemotherapy-Based Approach -- APL in Developing Countries: ATO based Approach -- Therapy-Related APL -- Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes -- Management of Treatment-Related Complications in APL.

This book covers all clinical aspects of acute respiratory distress syndrome (ARDS), from definition to treatment, focusing on the more recent recommendations and evidence-based medicine. The addressed topics are the various ventilation strategies, the impact of prone positioning, the use of partial and total extracorporeal support, the value of vasodilators, the weaning from mechanical ventilation, the pharmacological interventions, noninvasive ventilation, and the strategies using anti-inflammatory agents and stem cells. Furthermore, different related topics are also discussed, such as lung imaging, sedation, metabolic support, and hemodynamic instability. A concluding chapter specifically addresses ARDS in children. This up-to-date volume, written by experts in the field, will be of value for all health care practitioners seeking state of the art on the management of patients with this complex syndrome.

Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease. Although acute respiratory distress syndrome (ARDS) is defined by the acute onset of noncardiogenic pulmonary edema, hypoxemia and the need for mechanical ventilation, it is a heterogeneous disease entity, which makes it difficult to develop specific therapies. Treatment tends to focus on lung-protective ventilation, and no specific pharmacotherapies have been identified. All chapters were written by respected experts in the field, and summarize the latest trends, share recent research findings, and outline future prospects. Specific chapters are devoted to novel, promising diagnostic approaches, such as microRNA, which may improve our ability to identify early ARDS or at-risk patients. In addition, a dedicated chapter explores cell-based therapies and regenerative medicine, which offer potential therapeutic options. Acute Respiratory Distress Syndrome - Advances in Diagnostic Tools and Disease Management offers a valuable reference guide not only for young physicians and trainees, but also for experienced or teaching physicians, medical educators, and basic researchers. Readers will find the latest information on ARDS and come to understand the current challenges, encouraging them to further advance the diagnosis, treatment and clinical research on this disease.

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today's available information and guidance into a single, convenient resource.

Neural plasticity is high during developmental critical periods, then declines by adulthood. Here by acutely disrupting PirB function at different ages, we show that Paired immunoglobulin like receptor B (PirB) actively restricts plasticity both during and after the critical periopd. Chapter 1 introduces ocular dominance (OD) plasticity as a model of circuit and synaptic change, and presents a review of the literature on the study of mechanisms of OD plasticity, critical period timing, and manipulations that can alter plasticity later in life. Chapter 2 presents an overview of the methodological approaches used. PirB function was disrupted with temporal precision via either a conditional PirB allele or by minipump infusion of a soluble PirB ectodomain into mouse visual cortex. Chapter 3 details the effects of disrupting PirB function on plasticity in healthy animals. OD plasticity is enhanced not only during the critical period, but also when PirB function is disrupted in adulthood. The effects of adult deletion can occur even when PirB is only lost in excitatory neurons of the forebrain. Acute blockade of PirB for 10 days after the close of the critical period increases spine density on apical and basolateral dendrites of Layer 5 pyramidal neurons. Chapter 4 presents a proof of concept for therapeutic disruption of PirB function in cases of neurological dysfunction and disease. Long term monocular deprivation (LTMD) during the critical period leads to a lasting loss of vision in the deprived eye and to a decrease in dendritic spine density that does not recover even with subsequent binocular vision. However, acute blockade of PirB following LTMD allows for full recovery of spine density. MeCP2308/y mice, a mouse model of Rett Syndrome (a syndromic autism), were found to have increased MHC Class I expression and a concurrent loss of OD plasticity during the critical period, which can be rescued by acute blockade of PirB. Taken together, these results imply that mechanisms for enhanced structural and functional plasticity are present in adult visual cortex but are actively repressed by PirB. By removing negative regulators such as PirB, we show that it is possible to engage these endogenous mechanisms to facilitate recovery from otherwise irreversible effects of dysfunctional development. Our observations suggest that similar manipulations may be useful in other situations where restoring synaptic plasticity and increasing spine density have therapeutic value.

This book provides clear guidance on how to manage a wide range of side effects frequently encountered when treating patients with radiation therapy. For each potential side effect, incidence, mechanism, symptoms, and grading are carefully described. All aspects of management are addressed, drawing on the latest available evidence and highlighting key details of importance in clinical routine. The introduction of new radiation therapy techniques such as 3D conformal radiation therapy, intensity-modulated radiation therapy, and image-guided radiation therapy has reduced normal tissue doses and, accordingly, treatment complications. Nevertheless, a significant percentage of patients still experience acute side effects, in part because the threshold doses for these toxicities are typically lower than those for late effects. Acute toxicities may lead to interruption of treatment and be associated with an increase in late damage. A swift and effective response is therefore essential. This book will enable the reader to provide effective care for each side effect, thereby improving patient compliance with treatment and treatment outcomes.

You have just encountered a possible stroke patient. You ask yourself: what should I do first? How do I know it is a stroke? Is it too late to reverse the damage? This book provides integral assistance in answering these critical questions. All content is arranged in chronological order, covering all considerations in assessing and treating patients in the emergency room, stroke unit, and rehabilitation facilities. This new edition offers readers the latest information on stroke treatment, and features brand new chapters on stroke radiology, endovascular therapy, the uncommon causes of stroke, cerebral venous thrombosis, stroke prevention, and the transition to outpatient care. The comprehensive set of appendices contains useful reference information, including dosage algorithms, conversion factors, and stroke scales.

This book contains a compilation of the revolution of mechanical thrombectomy (MT) in the treatment of strokes. The initial chapters summarize information about the best medical management of acute ischemic stroke, imaging modalities and patient selection for MT. The book then focuses on the nuances of MT, providing detailed information about the best approaches for anesthesia during MT, access, intra-arterial thrombolysis, recent devices and catheters and technical pitfalls of MT. A specific chapter is dedicated to MT in the venous system. This is followed by a chapter about the most common complications of MT and post-procedural care of these patients. The last chapter covers different aspects of acute stroke care and MT in the developing world. The authors of this book comprise of a multidisciplinary group of world experts in the field and were encouraged to include teaching cases to deliver a book with a practical approach. Acute Stroke Management in the Era of Thrombectomy is intended for all healthcare providers who care for patients with stroke; with special emphasis for the proceduralists who are interested in technical tips to improve outcomes and minimize complications.

This book aims to familiarize readers with the most common acute surgery topics encountered in clinical practice and is unique in its use of infographics. It will be used in clinical rotations in surgery as a supplement to the knowledge gained, and will also provide instructors with a complementary tool, offering a wide-ranging guide to general aspects of acute surgery, with some hints on gynecologic and urologic emergencies. The book is intended to provide medical students and junior residents in medicine or surgery with a comprehensive and up-to-date overview of the most relevant operative techniques.

Brief introduction to the history of anti-doping / Ljungqvist, A. -- The development of the world anti-doping code / Young, R. -- Is the fight against doping in sport a legal minefield like any other? / Haas, U. -- How will the legal and sport environment influence a future code? / Niggli, O. -- Structure and development of the list of prohibited substances and methods / Kinahan, A.; Budgett, R.; Mazzoni, I. -- Therapeutic use exemptions / Gerrard, D.; Pipe, A. -- Challenges in modern anti-doping analytical science / Ayotte, C.; Miller, J.; Thevis, M. -- Achievements and challenges in anti-doping research / Bowers, L.D.; Bigard, X. -- Gene and cell doping : the new frontier : beyond myth or reality / Neuberger, E.W.I.; Simon, P. -- The athlete biological passport : how to personalize anti-doping testing across an athlete's career? / Robinson, N.; Sottas, P.-E.; Schumacher, Y.O. -- Next generation "omic" approaches in the "fight" against blood doping / Wang, G.; Karanikolou, A. ; Verdouka, I.; Friedmann, T.; Pitsiladis, Y. -- Integration of the forensic dimension into anti-doping strategies / Marclay, F.; Saugy, M. -- How to develop intelligence gathering in efficient and practical anti-doping activities / Holz, M; Robertson, J. -- Education in anti-doping: the art of self-imposed constraints / Loland, S. -- Can we better integrate the role of anti-doping in sports and society? : a psychological approach to contemporary value-based prevention / Petróczi, A. ; Norman, P.; Brueckner, S. -- Sport, society, and anti-doping policy : an ethical overview / Bloodworth, A.J.; McNamee, M. -- A moral foundation for anti-doping : how far have we progressed? where are the limits? / Murray, T.H. -- Conclusion and perspectives / Howman, D.

Accessible Routes -- Site Elements -- Vertical Access -- Architectural Elements -- Restrooms & Bathing Facilities -- Other Elements -- A Word or Two on Existing Projects -- Innovative Ideas on Access World-Wide.

"This clinically oriented book gives dental practitioners and students a hands-on guide to incorporating dental implants into their practices. Taking a clear and concise approach to the subject, the book offers basic information on all aspects of dental implants. Topics covered encompass the pros and cons of implants, patient factors, clinical considerations to success and failure, and implant restoration. Photographs, radiographs, and illustrations support the text, demonstrating the concepts discussed. The ADA Practical Guide to Dental Implants starts with a brief history of the subject then examines the clinical and economic considerations for implants. Patient factors, including systemic, oral, and periodontal health, diet, age, gender, and more are discussed. The book also looks at the experience of the clinician, followed by clinical considerations such as case planning, implant design, surgical techniques, antibiotics, and more. The last chapters cover post-surgical follow-up and the many factors that lead to a successful outcome. The ADA Practical Guide to Dental Implants is a useful introduction and guide to dental implants for any practitioner interested in incorporating implants into clinical practice"-- Provided by publisher.

The extraoral and intraoral soft tissue head and neck screening examination -- Soft tissue head and neck pathology description and documentation -- Common oral soft tissue lesions -- Differential diagnosis of common oral soft tissue lesions -- Guidelines for observation and/or referral of patients lesions -- The art and science of biopsy and cytology -- Sample patient histories and discussion.

Ch. 1. Approach to the patient with neurologic disease -- Ch. 2. Imaging, electrophysiologic, and laboratory techniques for neurologic diagnosis -- Ch. 3. Motor paralysis -- Ch. 5. Ataxia and disorders of cerebellar function -- Ch. 6. Tremor, myoclonus, focal dystonias, and tics -- Ch. 7. Disorders of stance and gait -- Ch. 10. Headache and other craniofacial pains -- Ch. 11. Pain i n the back, neck, and extreities -- Ch. 12. Disorders of smell and taste -- Ch. 13. Disturbances of vision -- Ch. 14. Disorders of ocular movement and pupillary function -- Ch. 15. Deafness, dizziness, and disorders of equilibrium -- Ch. 16. Epilepsy and other seizure disorders -- Ch. 17. Coma and related disorders of consciousness -- Ch. 18. Faintness and syncope -- Ch. 19. Sleep and its abnormalities -- Ch. 20. Delirium and other acute confusional states.

"The definitive text on the full spectrum of neurology presented in full color and better than ever! Long considered the field's gold-standard text, Adams and Victor's Principles of Neurology provides the very latest treatment and management strategies needed to confidently handle both common and rare neurologic conditions. Presented in full color, this classic resource meets the needs of the seasoned professional or the aspiring clinician, and has been hailed as the most detailed, thorough, and authoritative text on the subject. Reviewers have favorably compared the book's consistent, single voice to consulting with an experienced senior colleague. The latest scientific research is included in just the right amount of detail to serve as a clinical reference or a starting point for additional learning. The text is logically divided into six sections: The Clinical Method of Neurology; Cardinal Manifestations of Neurologic Disease; Growth and Development of the Nervous System in the Neurology of Aging; Major Categories of Neurologic Diseases; Diseases of the Spinal Cord, Peripheral Nerve, and Muscle; Psychiatric Disorders"-- Provided by publisher. "The wise application of science, evidence from trials, and the traditional virtues of the neurological history and examination are the main purpose of this edition of Principles of Neurology"-- Provided by publisher.

"Adams and Victor’s Principles of Neurology provides up to date treatment and management strategies needed to confidently handle both common and rare neurologic conditions. Presented in full color, this enduring resource meets the needs of today’s aspiring clinician or seasoned professional, and has been hailed as the most detailed, thorough, and authoritative text on the subject"-- Publisher's description.

This book highlights state-of-the-art research and practices for adaptation to climate change in food production systems (agriculture in particular) as observed in Japan and neighboring Asian countries. The main topics covered include the current scientific understanding of observed and projected climate change impacts on crop production and quality, modeling of autonomous and planned adaptation, and development of early warning and/or support systems for climate-related decision-making. Drawing on concrete real-world examples, the book provides readers with an essential overview of adaptation, from research to system development to practices, taking agriculture in Asia as the example. As such, it offers a valuable asset for all researchers and policymakers whose work involves adaptation planning, climate negotiations, and/or agricultural developments.

1. The Inductive Agency of Stress: From Perinatal to Adolescent Induction / Trevor Archer and Richard M. Kostrzewa -- Part I. Introductory Concepts -- 2. Making Sense of Stress: An Evolutionary-Developmental Framework / Marco Del Giudice, Bruce J. Ellis, and Elizabeth A. Shirtcliff -- 3. Prenatal and Maternal Psychosocial Stress in Primates: Adaptive Plasticity or Vulnerability to Pathology? / Dario Maestripieri and Amanda C.E. Klimczuk -- Part II. Adaptive and Maladaptive Consequences of Developmental Stress In Humans -- 4. The Everyday Stress Resilience Hypothesis: Unfolding Resilience from a Perspective of Everyday Stress and Coping / Jennifer A. DiCorcia, Akhila V. Sravish, and Ed Tronick -- 5. Ontogeny of Stress Reactivity in the Human Child: Phenotypic Flexibility, Trade-Offs, and Pathology / Mark V. Flinn, Davide Ponzi, Pablo Nepomnaschy, and Robert Noone -- 6. Consequences of Developmental Stress in Humans: Prenatal Stress / Nadine Skoluda and Urs M. Nater -- 7. Consequences of Developmental Stress in Humans: Adversity Experienced During Childhood and Adolescence / Urs M. Nater and Nadine Skoluda -- Part III. Adaptive and Maladaptive Consequences of Developmental Stress in Animal Models -- 8. Behavioural and Neuroendocrine Consequences of Prenatal Stress in Rat / Sara Morley-Fletcher, Jérôme Mairesse, and Stefania Maccari -- 9. Developmental Consequences of Prenatal Administration of Glucocorticoids in Rodents and Primates / Jonas Hauser -- 10. Early Developmental Trajectories of Brain Development: New Directions in the Search for Early Determinants of Health and Longevity / F. Cirulli and A. Berry -- 11. Adaptive Regulations in Developing Rodents Following Neonatal Challenges / Laurence Coutellier -- 12. Adaptive and Maladaptive Regulations in Response to Environmental Stress in Adolescent Rodents / Simone Macrì and Giovanni Laviola -- 13. Oxidative Stress and Hormetic Responses in the Early Life of Birds / David Costantini.

Organismic evolution involves both selective and neutral forces, although their relative contributions are often unknown. This thesis proposes novel statistical methods for analyzing genetic data from a variety of organisms, including yeast, Mycobacterium tuberculosis, and humans. The chapters of this thesis provide complimentary perspectives on the relative roles of selection and neutrality, from the molecular to the population level, and present various statistical tools for genetic data analysis. Chapter 2 proposes a maximum-likelihood based method with which to classify and identify interactions, or epistasis, between pairs of genes. Chapter 3 details a study of genetic data from Mycobacterium tuberculosis isolated from human Aboriginal Canadian communities; our analyses suggest that the bacterium spread to these communities via the Canadian fur trade in the 18th and 19th centuries. Chapter 4 discusses the detection of signatures of natural selection in the genomes of 12 diverse African human populations, and proposes novel considerations for identifying biological functions under selection and for comparing signals of selection between populations. Finally, Chapter 5 details the inference of the genetic basis and evolutionary history of light skin pigmentation and short stature in the genetically diverse [not equal to sign] Khomani Bushmen of the Kalahari Desert of South Africa, believed to be one of the world's most ancient human populations. These chapters emphasize that a more complete understanding of the evolutionary history of humans and other organisms requires not only the consideration of neutral and selective processes, but also both phenotypic and genetic information. The statistical methods and approaches presented in the following chapters have the potential to improve inferences of natural selection and demography from genetic data, as well as provide insight into the relative roles of both.

This dissertation studies mechanisms that mediate inhibitory and excitatory synaptic transmission in the healthy brain and in animal models of stroke and epilepsy. Stroke is a major cause of disability yet lacks pharmacotherapies for recovery (Donnan et al., 2008). During the repair phase, spontaneous cortical circuit plasticity and reorganization adjacent to the stroke site (peri-infarct) promote functional recovery (Carmichael, 2006; Dijkhuizen et al., 2001; Murphy and Corbett, 2009; Nudo et al., 1996). Elucidating mechanisms that target these endogenous brain repair processes could lead to new therapeutics with a broad treatment window. Inhibiting the post stroke increase in tonic (extrasynaptic) GABA signaling during the repair phase was reported to enhance functional recovery in mice, suggesting that GABA plays an important function in modulating brain repair (Clarkson et al., 2010). While tonic GABA appears to suppress brain repair after stroke, the role of phasic (synaptic) GABA during the repair phase is unknown. In Chapter 2, we report a post-synaptic increase in phasic GABA signaling within the peri-infarct cortex that is specific to layer 5 pyramidal neurons; we measured increased numbers of alpha-1 receptor subunit containing GABAergic synapses detected using array tomography, and an associated increased efficacy of spontaneous and miniature inhibitory post-synaptic currents in pyramidal neurons. In contrast to the reported effects of tonic inhibition, enhancing phasic GABA signaling in the recovery phase using zolpidem, an alpha-1 subunit positive allosteric modulator (Crestani et al., 2000), improved behavioral recovery. These data identify a novel role for phasic GABA signaling in brain repair, indicate zolpidem's potential to improve recovery, and underscore the necessity to distinguish the role of tonic and phasic inhibition in stroke recovery. Temporal lobe epilepsy (TLE) is the most common form of adult seizure disorder and is often associated with drug refractory epilepsy (Wiebe, 2000). GABAARs are thought to play a key role in the pathophysiology of many types of epilepsy, including TLE, and are the target site of benzodiazepines, commonly used as antiepileptic medications (Noebels et al., 2012a; Gonzalez and Brooks-Kayal, 2011). Previous studies have shown dentate granule cells display an increased pharmacological response to the central benzodiazepine receptor (CBR) antagonist flumazenil (FLZ) after status epilepticus (SE) in an animal model of temporal lobe epilepsy. It has been previously reported that in slices taken from pilocarpine-induced epileptic rats, hippocampal dentate granule cells demonstrate a FLZ induced reduction in mIPSC half width. This is in contrast to control animals, where FLZ application has no effect on dentate granule cell mIPSC kinetics. The mechanism(s) by which FLZ reduces mIPSC half width in SE tissue is not known, but one hypothesis is that an endogenous compound active at the CBR may be upregulated after SE. However, in Chapter 3 I performed preliminary experiments in animals with SE and did not find a consistent reduction in mIPSC parameters after SE previously reported (Leroy et al., 2004). My results demonstrate that FLZ is not acting as a pure negative allosteric modulator (NAM), but instead may act occasionally as a NAM and predominantly as a positive allosteric modulator (PAM) or that NAMs are expressed after seizures and actually weaken IPSCs. These experiments suggest that a small subset of dentate granule cells respond to FLZ with varying response profiles. Synaptic transmission requires a continuous supply of neurotransmitter for release. Although most types of neurons use direct reuptake to recycle released neurotransmitters, evidence indicates that glutamatergic synapses rely predominantly on astrocytes for generation and recycling of glutamate (Hertz, 1979). Although biochemical studies suggest that excitatory neurons are metabolically coupled with astrocytes to generate the glutamate necessary to maintain glutamatergic neurotransmission, direct electrophysiological evidence is lacking. In fact, a requirement for the cycle has only been demonstrated during epileptiform activity, a disease setting in which glutamate release is greatly increased (Bacci et al., 2002; Otsuki et al., 2005; Tani et al., 2010). The large distance between cell bodies and axon terminals limits the contribution of somatic sources to the pool of glutamate available for synaptic release and predicts that glutamine-glutamate cycle is synaptically localized. In Chapter 4, we investigated neurotransmitter release from isolated nerve terminals in brain slices by transecting hippocampal Schaffer collaterals and cortical layer I axons. Stimulating with alternating periods of high frequency (20 Hz) and rest (0.2 Hz), we identified an activity-dependent reduction in synaptic efficacy that correlated with reduced glutamate release. This was enhanced by inhibition of astrocytic glutamine synthetase and reversed or prevented by exogenous glutamine. Importantly, this activity dependence was also revealed with an in vivo derived natural stimulus both at network and cellular levels. These data provide direct electrophysiological evidence that an astrocyte-dependent glutamate-glutamine cycle is required to maintain active neurotransmission at excitatory terminals.

Myelin sheaths, specialized segments of oligodendrocyte plasma membranes in the central nervous system, facilitate fast, saltatory conduction of action potentials down axons. Myelination of the central nervous system requires the generation of functionally mature oligodendrocytes from oligodendrocyte precursor cells. Changes to the fine structure of myelin in a neural circuit are expected to affect conduction velocity of action potentials. Recent evidence from humans and animal models suggests that myelination may be sensitive to experiences during development and adulthood, and that varying levels of neuronal activity may underlie these experience-dependent changes in myelin and myelin-forming cells, perhaps selectively instructing myelination of an active neural circuit. In this thesis, I present work using optogenetic stimulation of premotor cortex in awake, behaving mice to demonstrate that neuronal activity elicits a mitogenic response of neural and oligodendrocyte precursor cells, promotes oligodendrogenesis and increases myelination within the deep layers of the premotor cortex and subcortical white matter. Neuronal activity-regulated oligodendrogenesis and myelination is associated with improved motor function of the corresponding limb. Oligodendrogenesis and myelination appear necessary for the observed functional improvement, as epigenetic blockade of oligodendrocyte differentiation and myelin changes prevents the activity-regulated behavioral improvement. A deeper understanding of adaptive myelination may provide insights into diseases involving damage and dysregulation of myelin and myelin-forming cells.

An evidence-based review of diagnostic and treatment strategies for successfully managing alcohol and substance use disorders in older adults. With contributions from leaders in the field of addiction treatment, this volume offers the most current clinical recommendations and describes best practices for implementing effective treatments in this growing patient population.

1. The nature of addictive disorders / John B. Saunders -- 2. Epidemiology and prevention / Peter Anderson, Katherine M. Conigrave, Louisa Degenhardt, Wayne Hall, and Tim Stockwell -- 3. Pharmacology and pathophysiology / Kazutaka Ikeda, Daisuke Nishizawa, David J. Nutt, and John B. Saunders -- 4. The scope of intervention / Sawitri Assanangkornchai and John B. Saunders -- 5. Establishing the diagnosis / Glenys Dore, Noeline C. Latt, and John B. Saunders -- 6. Acute care / Glenys Dore, Noeline C. Latt, E. Jane Marshall, John B. Saunders, and Peter Thompson -- 7. Ongoing management of substance use disorders / Stephen Jurd and John B. Saunders -- 8. Tobacco / Renee Bittoun, Katherine M. Conigrave, Hisatsugu Miyata, and Nicholas Zwar -- 9. Alcohol / Robert Batey, Katherine M. Conigrave, Colin Drummond, Noeline C. Latt, E. Jane Marshall, David J. Nutt, Richard Saitz, and John B. Saunders -- 10. Cannabis / H. Valerie Curran, Margaret Haney, David J. Nutt, and John B. Saunders -- 11. Opioids / Robert Batey, Katherine M. Conigrave, Noeline C. Latt, David J. Nutt, John B. Saunders, Andrew J. Saxon, and George Woody -- 12. Pain and opioids / James Bell -- 13. Benzodiazepines and the other sedative-hypnotics / Noeline C. Latt, David J. Nutt, and John B. Saunders -- 14. Psychostimulants / Glenys Dore, Walter Ling, and David J. Nutt -- 15. Hallucinogens and dissociative drugs / David J. Nutt and Adam R. Winstock -- 16. Other drugs / Jenny Bearn, Jonathan Brett, Adam Brodie, Katherine M. Conigrave, Shivani Khan, Janie Sheridan, Iain Smith, Catherine Woodstock Striley, David Taylor, and Adam R. Winstock -- 17. Polysubstance use / Jason P. Connor and Gerald F. X. Feeney -- 18. Injecting drug use / Robert Batey, Katherine M. Conigrave, Paul Haber, and John Strang -- 19. Gambling / Henrietta Bowden-Jones, Sanju George, Yasunobu Komoto, David J. Nutt, <i>and Taku Sato</i> -- 20. Gaming / Hideki Nakayama and Hiroshi Sakuma -- 21. Other addictive disorders / Takayuki Harada, Susumu Higuchi, Satoko Mihara, and John B. Saunders -- 22. Psychiatric comorbidity / Glenys Dore, Anne Lingford-Hughes, and John B. Saunders -- 23. Specific clinical situations / Noeline C. Latt, John B. Saunders, and Sue Wilson -- 24. Special populations / Sawitri Assanangkornchai, Tatiana Balachova, Yvonne Bonomo, Katherine M. Conigrave, Ilana B. Crome, Glenys Dore, Bradley Freeburn, Marianne Jauncey, Michael Levy, Corinne Lim, Ross McCormick, and Kim Wolff -- 25. Substance use and specific health care settings / Jonathan Brett, Tim Neumann, Richard Saitz, John B. Saunders, Claudia Spies, and Pierluigi Struzzo -- 26. Legal and ethical issues / Katherine M. Conigrave, Glenys Dore, Emily Finch, Ralph Hingson, Noeline C. Latt, Sally Porter, and John B. Saunders.

This book provides an accessible, up-to-date understanding of how to treat patients with substance and non-substance-related addiction. It covers all the typical substance and non-substance use disorders and presents evidence in a case-based format. Concise and comprehensive, opening chapters relay a preliminary assessment of addiction disorders and their neurobiology. Subsequent chapters then offer specific treatment options, challenges, and cases relating to the abuse of distinct substances. The substances mentioned earlier include alcohol, opioids, stimulants, hallucinogens, and sedatives. Additionally, one chapter covers the unique issues associated with treating behavioral addictions, such as sex and gambling. Each chapter will outline cases in a fashion that will optimize the reader's experience. In closing, the book examines co-occurring substance use disorders and mental illness. An invaluable addition to the Psychiatry Update Series, Addiction Medicine is an essential reference for mental health clinicians, as well as primary care and family medicine clinicians.

"Integrating scientific knowledge with today’s most effective treatment options, Addiction Medicine: Science and Practice, 2nd Edition, provides a wealth of information on addictions to substances and behavioral addictions. It discusses the concrete research on how the brain and body are affected by addictions, improving your understanding of how patients develop addictions and how best to personalize treatment and improve outcomes. This essential text is ideal for anyone who deals with patients with addictions in clinical practice, including psychiatrists, health psychologists, pharmacologists, social workers, drug counselors, trainees, and general physicians/family practitioners"--Publisher's description.

"While there is a wealth of published information on addiction medicine, the psychological aspects of alcohol abuse, and behavioral medicine with regard to addiction, virtually none of the existing resources were written with the primary care provider in mind. Addressing Unhealthy Alcohol Use in Primary Care is a handy reference for primary care clinicians who are confronted by patients with these problems daily, and who wish to successfully address these issues in their practice. Focusing on the literature and science relevant to practicing providers, this book covers the range of interventions appropriate for this setting. Topics include assessment, brief counseling interventions, pharmacotherapy, referrals to both specialty care and Alcoholics Anonymous (and other self-help programs), psychiatric comorbidity and other drug use, and other information specific to the needs of the primary care clinician. The vast majority of people with health risks and consequences related to alcohol use receive little to no attention from healthcare, despite the fact that alcohol is a leading cause of early preventable death. This book is a guide to identifying and addressing unhealthy alcohol use in hopes of improving the lives of patients."--publisher's website

This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical atlas documenting the techniques used in the EGJ region, with superb color images and stepwise description of procedures. Against the background of the rapidly increasing incidence in EGJ cancer, especially evident in Western countries, there is a need for greater uniformity in management strategies, which currently vary significantly across the world. This book provides appropriate guidance that will assist all practitioners involved in the diagnosis and treatment of EGJ cancers, including surgeons, oncologists, and radiotherapists.

This book aims to provide updated facts and treatments for practicing gynecologists and postgraduate doctors to enhance their understanding of pathogenesis, pathology, symptoms and diagnostic imaging technology of adenomyosis, such as to select appropriate treatments, to improve the symptoms, fertility and the quality of life of women with adenomyosis. This book also particularly introduces the new treatment for adenomyosis using the non-invasive High Intensity Focused Ultrasound ablation treatment. Hopefully, it will provide a better understanding of its operation, effectiveness, and pregnancy outcome, to formulate a more successful treatment strategy for this disease.

Adenosine and Metabolism--A Brief Historical Note / Bertil B. Fredholm -- Adenosine Metabolism, Adenosine Kinase, and Evolution / Jaoek Park and Radhey S. Gupta -- Adenosine and Energy Metabolism--Relationship to Brain Bioenergetics / Xuesong Chen, Liang Hui and Jonathan D. Geiger -- Adenosine and Autocrine Metabolic Regulation of Neuronal Activity / Masahito Kawamura Jr. and David N. Ruskin -- Physiologic and Metabolic Regulation of Adenosine: Mechanisms / Chris G. Dulla and Susan A. Masino -- The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books / Stephanie zur Nedden, Alexander S. Doney and Bruno G. Frenguelli -- Downstream Pathways of Adenosine / Ana M. Sebastião, Sofia Cristóvão-Ferreira and Joaquim A. Ribeiro -- Astrocytic ATP Release / Dustin J. Hines and Philip G. Haydon -- Role of Striatal A2A Receptor Subpopulations in Neurological Disorders / Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart and Seema Gulyani, et al. -- Sleep and Adenosine: Human Studies / Tarja Porkka-Heiskanen -- Adenosine and Other Purinergic Products in Circadian Timing / Christine Muheim and Steven A. Brown -- Adenosine in the Immune System / György Hask, Balázs Koscsó́ and Balázs Csóka -- The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation / Kelly L. Drew and Tulasi R. Jinka -- Adenosine and Stroke / Felicita Pedata, Anna Maria Pugliese, Francesca Corti and Alessia Melani -- The Many Roles of Adenosine in Traumatic Brain Injury / Patrick M. Kochanek, Jonathan D. Verrier, Amy K. Wagner and Edwin K. Jackson -- Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury / Kwaku D. Nantwi -- Adenosine and Pain / Jana Sawynok -- Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson's Disease / Annalisa Pinna, Nicola Simola, Lucia Frau and Micaela Morelli -- Adenosine Receptors and Alzheimer's Disease / David Blum, Ursula Sandau, Cyril Laurent, Vânia Batalha and Antoine Leboucher, et al. -- Adenosine Receptors in Huntington's Disease / David Blum, Alberto Martire, Sylvie Burnouf, Bernard Sablonnière and Pierre Krystkowiak, et al. -- Adenosine and Multiple Sclerosis / Maria Victoria Sánchez-Gómez, Estibaliz González-Fernández, Rogelio O. Arellano and Carlos Matute -- Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis / Benjamin K. Yee, Philipp Singer and Detlev Boison -- The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation / John D. Salamone, Merce Correa, Patrick A. Randall, Eric J. Nunes and Marta Pardo, et al. -- Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities / Julia Svedova, Inge-Marie Eigsti and Susan A. Masino -- Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes / Traci N. Plumb, Sarah R. Sterlace, Kelly A. Cavanaugh and Thomas R. Minor -- Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation / Detlev Boison -- Ketogenic Diet and Epilepsy: The Role of Adenosine / Jong M. Rho, Beth Zupec-Kania and Susan A. Masino -- Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery / Eleanor M. Pritchard, Detlev Boison and David L. Kaplan -- Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy / Zsolt Kovács and Arpád Dobolyi.

Adenosine receptor biology in the central nervous system / Michael Freissmuth and Karl-Norbert Klotz -- Adenosine signaling throughout development / Stefania Zappettini and Christophe Bernard -- Influence of adenosine on synaptic excitability / Detlev Boison, Raquel B. Dias, Traci Plumb, Sofia Cristóvão-Ferreira and Ana M. Sebastião -- Regulation of synaptic transmission by adenosine at the neuromuscular junction / Paula Pousinha and Joaquim A. Ribeiro -- Gene regulation of adenosine A₂a receptors in the central nervous system -- Sleep, adenosine, and neurodegeneration / Theresa E. Bjorness and Robert W. Greene -- National vs glial cell contribution to adenosine A₂a receptor-induced neurodegeneration / Antonella Ferrante, Maria T. Tebano, Alberto Martire, Maria R. Domenici and Patrizia Popoli -- Adenosine and oxygen/glucose deprivation in the brain / Felicita Pedata, Ilaria Dettori, Irene Fusco, Elisabetta Coppi, Anna M. Pugliese and Alessia Melani -- Adenosine receptors and memory disorders / Alexandre De Mendonca, David Blum and Jonathan D. Geiger -- Control of motor function by adenosine A₂a receptors in Parkinson's and Huntington's disease / Annalisa Pinna, Jadwiga Wardas, Maria R. Domenici, Patrizia Popoli, Giovanni Cossu and Micaela Morelli -- Adenosine receptors oligomers in Parkinson's disease / Víctor Fernández-Dueñas and Francisco Ciruela -- Adenosine control of striatal function / Sergi Ferré.

Biophysical methods to monitor structural aspects of the adenovirus infectous cycle / Rosa Menéndez-Conejero ... [et al.] -- Proteome analysis of adenovirus using mass spectrometry / Sara Bergström Lind, Konstantin A. Artemenko, and Ulf Pettersson -- Capsid modification strategies for detargeting adenoviral vectors / Alan L. Parker ... [et al.] -- Use of dodecahedron "VLPs" as an alternative to the whole adenovirus / Pascal Fender -- Study of adenovirus and CAR axonal transport in primary neurons / Charleine Zussy and Sara Salinas -- The use of chromatin immunoprecipitation (hIP) to study the binding of viral proteins to the adenovirus genome in vivo / Yueting Zheng and Patrick Hearing -- DNA microarray to analyze adenovirus-host interactions / Stefania Piersanti, Enrico Tagliafico, and Isabella Saggio -- Determination of the transforming activities of adenovirus oncogenes / Thomas Speiseder, Michael Nevels, and Thomas Dobner -- Oncolytic adenovirus characterization : activity and immune responses / Raul Gil-Hoyos, Juan Miguel-Camacho, and Ramon Alemany -- The analysis of innate immune response to adenovirus using antibody arrays / Nelson C. Di Paolo and Dmitry M. Shayakhmetov -- Engineering adenovirus genome by bacterial artificil chromosome (BAC) technology / Zsolt Ruzsics, Frederic Lemnitzer, and Christian Thirion -- Construction, production, and purification of recombinant adenovirus vectors / Susana Miravet ... [et al.] -- Sealable production of adenovirus vectors / Ana Carina Silva ... [et al.] -- Canine adenovirus downstream processing protocol / Meritxell Puig ... [et al.] -- Production of high-capacity adenovirus vectors / Florian Kreppel -- Production of chimeric adenovirus / Marta Miralles ... [et al.]

Adenovirus infection: Global Status is one in a series of GIDEON ebooks which explore all individual infectious diseases, drugs, vaccines, outbreaks, surveys and pathogens in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature. The ebook includes: 1. Descriptive epidemiology 2. Clinical features 3. Distribution map 4. Images 5. Global status and status in every relevant country 6. References.

Parents will find the latest recommendations for the treatment and care of children with ADHD in the fully revised and updated edition of this award-winning guide.

Neuroscience, Neuropsychology, and Attention-Deficit Hyperactivity Disorder: ADHD as a Model of Brain-Behavior Relationships -- ADHD, Attention, and DSM Diagnosis: History and Context -- ADHD and Neuropsychological Nomenclature -- Diagnostic Systems and Etiological Models -- Neuropsychological Models of Attention and ADHD -- Broad-Based Neuropsychological Test Batteries and ADHD -- Preliminary Answers to the Question -- Dimensional Approaches for Evaluating Disorders: Research Domain Criteria -- The Neocortex, Regional Functional Specialization, and Cognitive Networks -- Large-Scale Brain Networks and Functional Connectivity -- The Ontogeny of Functional Brain Networks -- Large-Scale Brain Network Disturbances in ADHD -- The Selection Problem -- The Basal Ganglia -- The Basal Ganglia and Intention Programs -- The Basal Ganglia: Focused Attention and Learning Through Integrative Networks -- Reward Circuitry and the Basal Ganglia -- The Cerebellum -- The Modular Organization of the Cerebellum -- The Development of Motor Skills, Executive Functions, and a Relationship to ADHD: A Preliminary Review -- Revisiting Neuropsychological Testing and the Paradox of ADHD -- Neural Network Dynamics: How Large-Scale Brain Networks Interact -- Concluding Remarks.

ADHD in Adults: A Practical Guide to Evaluation and Management is the product of a unique collaboration of international specialists. This volume offers easy-to-read guidance, and includes checklists, rating scales and treatment planning tools. It was designed for a broad audience of caregivers working in diverse settings, including psychiatrists, social workers, primary care physicians, nurse specialists and psychologists. The authors are highly acclaimed clinicians, investigators and educators. They offer step-by-step guidance for implementation of best practices, drawing from clinical research and their experience treating thousands of patients. They cover diagnosis, treatment planning, and state-of-the-art application of pharmacology, psychotherapy, skill-building, family system and environmental interventions - for both simple and complex cases. The scales and worksheets in this Guide were developed to efficiently facilitate assessment and management. The Editor is an international leader in the field from the Clinical and Research Program in Adult ADHD at Massachusetts General Hospital (MGH) and Harvard Medical School, which has made pioneering and highly cited contributions to the understanding of ADHD. This Guide is a definitive, indispensable resource for all health providers who wish to optimize their approach to adult patients with ADHD.

"Attention-deficit/hyperactivity sisorder (ADHD) is one of the most common behavior disorders of childhood. Mental health and school practitioners are frequently faced with the challenge of assessing children and adolescents who might have ADHD. The ADHD Rating Scale-5 is widely used by medical, mental health, and educational practitioners for a variety of activities including screening, diagnostic assessment, and evaluation of treatment outcome"--Provided by publisher.

Part I. What is known about adherence behavior -- 1. Impact of Non-Adherence in Dermatology -- 2. Models of Adherence -- 3. Impact of demographic and treatment-related factors -- 4. Non-attendance, predictors and interventions -- Part II. Methods of measuring adherence -- 5. Using Retrospective Databases to Study Adherence -- 6. Measuring Adherence in Clinical Trials -- 7. How providers can assess their patients' adherence in clinical settings -- Part III. Adherence in specific diseases -- 8. Topical application and variability of the de facto applied dose: technical aspects -- 9. Adherence in Acne -- 10. Psoriasis and adherence to therapy: individual, treatment-related and general factors -- 11. Adherence in atopic dermatitis -- 12. Adherence in Other Dermatologic Conditions -- Part IV. Strategies to improve adherence -- 13. Optimizing the Physician-Patient Relationship and Educating the Patient about Adherence -- 14. Choosing the treatment the patient is most likely to use -- 15. Dealing with forgetfulness -- 16. Building Motivation and Self-Efficacy.

Poor adherence to therapy is one of the main obstacles to treatment effectiveness in schizophrenia. It is the main determinant of relapse, hospitalization, symptom persistence, and poor psychosocial functioning and outcome. Adherence to treatment is affected by various factors related to the disease characteristics, to the patient him- or herself, to the treatment, and to the therapeutic relationship. Some of these factors are modifiable, and both pharmacological and non-pharmacological strategies have been developed for this purpose.This book addresses the different aspects of adherence to treatment in schizophrenia and related disorders in a systematic but easy-to-use manual format. Chapters focus on a full range of issues, including pharmacological and non-pharmacological strategies to enhance adherence and continuity of care, relevant psychological factors, the importance of the patient-doctor relationship, and the need for an alliance with other care-givers. Adherence to Antipsychotics in Schizophrenia will be an invaluable asset for all who are involved in the care of patients with schizophrenia.

The book documents the history of the prevention-of-mother-to child transmission of HIV (PMTCT) program in Guyana, as well as the impact of HIV on pregnant and postpartum women's adherence to antiretroviral therapy (ART). The book shows research work by reviewing the literature to investigate relevant adherence studies, presenting in-depth interviews on adherence perspectives of clinic patients and healthcare providers, and a cross-sectional descriptive study of pregnant women that investigated general adherence to pregnancy-related behaviours and ART, and the efficacy of a theoretical model (Health Belief Model) to understand and predict ART adherence within this group. Author discusses the factors affecting ART adherence among pregnant and postpartum women, since existing studies may not account for cultural and other local variations. The findings provide insight into the local situation, and will also inform policy and practice in Guyana, and the wider Caribbean Community (CARICOM).

Staphylococcus aureus is both a transient skin colonizer and a formidable human pathogen, ranking among the leading causes of skin and soft tissue infections as well as severe pneumonia. The secreted bacterial alpha-toxin is essential for S. aureus virulence in these epithelial diseases. To discover host cellular factors required for alpha-toxin cytotoxicity, we conducted a genetic screen using mutagenized haploid human cells. Our screen identified a cytoplasmic member of the adherens junctions, plekstrin-homology domain containing protein 7 (PLEKHA7), as the second most significantly enriched gene after the known alpha-toxin receptor, a disintegrin and metalloprotease 10 (ADAM10). Here we report a new, unexpected role for PLEKHA7 and several components of cellular adherens junctions in controlling susceptibility to S. aureus alpha-toxin. We find that despite being injured by alpha-toxin pore formation, PLEKHA7 knockout cells recover after intoxication. By infecting PLEKHA7−/− mice with methicillin-resistant S. aureus USA300 LAC strain, we demonstrate that this junctional protein controls disease severity in both skin infection and lethal S. aureus pneumonia. Our results suggest that adherens junctions actively control cellular responses to a potent pore-forming bacterial toxin and identify PLEKHA7 as a potential non-essential host target to reduce S. aureus virulence during epithelial infections.

Introduction: history of the adhesion GPCR field / J̲örg Hamann, Alexander G. Petrenko -- Molecular and pharmacological properties of adhesion GPCRs. Classification, nomenclature, and structural aspects of adhesion GPCRs / Arunkumar Krishnan, Saskia Nijmeijer, Chris de Graaf, Helgi B. Schi̲th -- 7TM domain structure of adhesion GPCRs / Chris de Graaf, Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst -- Understanding the structural basis of adhesion GPCR functions / Demet Araç, Norbert Sträter, Elena Seiradake -- Control of adhesion GPCR function through proteolytic processing / Matthias Nieberler, Robert J. Kittel, Alexander G. Petrenko, Hsi-Hsien Lin [and others] -- Tethered agonism: a common activation mechanism of adhesion GPCRs / Ines Liebscher, Torsten Sch̲öneberg -- Versatile signaling activity of adhesion GPCRs / Ayush Kishore, Randy A. Hall -- Adhesion GPCR-related protein networks / Barbara Knapp, Uwe Wolfrum -- The relevance of genomic signatures at adhesion GPCR loci in humans / Peter Kovacs, Torsten Sch̲öneberg -- Adhesion GPCRs as pharmakotargets in organ function and development. Adhesion GPCRs as a putative class of metabotropic mechanosensors / Nicole Scholz, Kelly R. Monk, Robert J. Kittel, Tobias Langenhan -- Adhesion GPCRs govern polarity of epithelia and cell migration / David Strutt, Ralf Schnabel, Franziska Fiedler, Simone Pr̲mel -- Adhesion GPCRs as novel actors in neural and glial cell functions: from synaptogenesis to myelination / Séverine M. Sigoillot, Kelly R. Monk, Xianhua Piao, Fekrije Selimi, Breanne L. Harty -- Control of skeletal muscle cell growth and size through adhesion GPCRs / James P. White -- Adhesion GPCR function in pulmonary development and disease / Marie-Gabrielle Ludwig, Klaus Seuwen, James P. Bridges -- Adhesion GPCRs as modulators of immune cell function / J̲örg Hamann, Cheng-Chih Hsiao, Chang Sup Lee, Kodi S. Ravichandran, Hsi-Hsien Lin -- Heart development, angiogenesis, and blood-brain barrier function is modulated by adhesion GPCRs / Gentian Musa, Felix B. Engel, Colin Niaudet -- Adhesion GPCRs in tumorigenesis / Gabriela Aust, Dan Zhu, Erwin G. Van Meir, Lei Xu.

This book focuses on the subsets of soft tissue tumors that show adipocytic, vascular or skeletal muscle differentiation. It reviews the surgical pathologists approach to diagnosing soft tissue tumors guided by vital morphological and immunohistochemical data in the differential diagnosis of this family of tumors. Written by experts in the field, the text contains a concise yet comprehensive summary of the current status of the field that helps guide diagnosis and patient management, and stimulates investigative efforts. The book is filled with high-quality drawings of the salient histologic features of these various tumors, alongside photomicrographs and tips and tricks that help the relatively untrained or inexperienced eye to recognize the various structures or cell types that comprise each of these lesions. This innovative approach seeks to make recognition of these tumors easier. Adipocytic, Vascular and Skeletal Muscle Tumors serves as a valuable resource for pathologists, oncologists, surgeons, and researchers dealing with and interested in these complex and challenging tumors.

Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes, stromal cells, immune cells and vascular elements, with adipose tissue depots in other locations throughout the body and with other tissues in order to regulate physiologic processes of energy intake, utilization, and distribution. Since disturbances, both qualitative and quantitative, in adipocytokine function contribute significantly to many of the comorbidities associated with obesity, including diabetes, cardiovascular disease and cancer, this volume, which discusses most of the major adipocytokines independently and collectively and their roles in normal and pathologic processes, should be useful to all individuals seeking a deeper understanding of these processes. Moreover, it provides a valuable complement to the series on Energy Balance and Cancer, in which each volume is focused on a specific aspect of this process, which now constitutes an expanding problem as the obesity pandemic continues and more of the population reaches the age where cancer is most prevalent. This volume should provide a valuable resource to all clinicians and scientists engaged in caring for susceptible patients and in exploring the relation between energy balance and cancer as well as an important platform to providing the background for research development.

The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

Preface: Obesity, Adipose Tissue and Cancer Progression -- Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link -- Increased Adiposity and Colorectal Cancer -- Adiposity and Diabetes in Breast and Prostate Cancer -- Increased Adipocity and Endometrial Cancer Risk -- Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer -- Animal Models to Study the Interplay between Cancer and Obesity -- Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved -- Trafficking of Cells from Adipose Tissue to Tumor Microenvironment -- The Impact of Obesity Intervention on Cancer: Clinical Perspectives -- Index.

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.

Traces the author's post-retirement work as a surgeon and teacher in such remote areas as Nepal and Ukraine, illuminating the challenges of working in difficult regions and finding purposeful work after a career.

This concise guide takes a practical approach to adolescent and young adult (AYA) rheumatology, aiming to cover the needs of any healthcare professional dealing with young people aged 10-24 years. Each chapter contains key management points for readers to readily access disease-specific management as well as highlighting specific AYA issues which differ from pediatric and adult practice. The coverage is comprehensive but concise and designed to act as a primary reference tool for subjects across the field of rheumatology. The book is designed for pediatric/adult rheumatologists, primary care physicians, nurses, allied health professionals and other professionals to understand each topic covered and to take a practical approach to to delivering developmentally appropriate rheumatology health care.

This reader-friendly book takes a practical approach to caring for the adolescent athlete. Logically organized by joint, experts in sports medicine address both chronic and acute injuries in addition to congenital conditions.

Adolescent brain development is a fascinating, newly developing field that has so much to offer almost anyone interested in learning more. Adolescence has only come to be established as a unique developmental phase in the last few decades or so. We now know that the human brain undergoes dramatic developmental changes in the postnatal period, not only early after birth but also extending all the way into adulthood. These changes are not uniform, in that the brain regions undergoing the most change during adolescence are not the same as the regions that changed most in the early life period, and the processes of change also differ as we age. Some of the most important changes that we see during the adolescent period are: 1) pruning (or removal) of excessive neural connections, 2) increases in white matter, the portion of brain matter that allows different regions to communicate with one another, and 3) thinning of the cortex, which is comprised of the outer layers of brain matter. Compared with other areas of the brain, the frontal and temporal cortices undergo the most protracted changes in their structure, implying that developments in these areas play a large role in providing the foundation for adolescent behavioural changes. In this book, we compare adolescent behavioural changes with ongoing changes in the brain and discuss potential implications for health and educational policy-making.

AMSTARs: Adolescent Contraception: Basics and Beyond highlights the fundamental aspects of contraception with an overview of contraceptive methods and epidemiology, provides up-to-date guidance on medical eligibility criteria, and reviews critical policy advances supporting contraceptive access.

Adolescent Dating Violence: Theory, Research, and Prevention summarizes the course, risk/protective factors, consequences and treatment/prevention of adolescent dating violence. Dating violence is defined as physical, sexual, psychological, and cyber behavior meant to cause emotional, physical, or social harm to a current or former intimate partner. The book discusses research design and measurement in the field, focuses on the recent influx of longitudinal studies, and examines prevention and intervention initiatives. Divided into five sections, the book begins by reviewing theory on and consequences of dating violence. Section II discusses risk factors and protective factors such as peer influences, substance use, and past exposure to violence in the family of origin. Section III discusses how social and cultural factors can influence teen dating violence, addressing the prevalence of dating violence among different ethnicities and among LGBTQ teens, and the influence of social media. Section IV discusses recent research priorities including gender inequality, measurement, psychological abuse, and the dual nature of dating violence during adolescence. Section V reviews evidence-based practice for treatment and prevention across various age groups and settings.

"This book offers a comprehensive and clinically relevant survey of adolescent gynecology. Adolescent Gynecology: A Clinical Casebook addresses the many intersecting considerations of gynecologic and reproductive health care for this population using a concise, case-based format. Organized in four sections, the first introduces chapters on adolescent confidentiality, puberty, and well care. Section II covers varied menstrual disorders, while Section III highlights issues in reproductive health care including sexually transmitted infection and adolescent pregnancy. Finally, Section IV addresses special populations of adolescents, including chapters on girls who have sex with girls, girls who are victims of abuse and girls with special health care needs and chronic health conditions. In each section common gynecologic health issues are discussed in the context of these clinical cases, provide the knowledge needed to further improve comprehensive care of adolescent patients.Adolescent Gynecology: A Clinical Casebook is a unique resource that delivers essential clinical information for Adolescent Medicine and Pediatric and Adolescent Gynecology fellowship trainees, as well as for medical students, resident trainees, and primary care practitioners who are the front-line caregivers for adolescent girls"--Provided by publisher.

This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and the clinical and prognostic implications of primordial prevention in healthy adolescents. All of these elements are subsequently reviewed using a multidimensional approach, in order to offer extensive information on the complex changes that characterize adolescents' physiological, psychological, and neurobiological development. In addition, the book depicts the preventive strategies currently used in various social settings (school, family, sport club, health policies) aimed not only at reducing lifestyle risk behaviors, but also at improving resilience, happiness, social involvement, self-esteem, and sociability. This update is essential in the light of the fact that, to date, prevention has mainly been directed towards adolescents with physical or mental disorders rather than their healthy peers. As such, the book offers a valuable tool for pediatricians, child and adolescents psychiatrists, and for all professionals involved in Health Promotion and Disease Prevention.

1. Introduction -- 2. Description of the Disorder -- 3. Theoretical Models and Rationale -- 4. Diagnosis and Treatment Indications -- 5. Treatment -- 6. Adolescent Identity Treatment (AIT) Case Illustration -- 7. Efficacy -- 8. Training and Supervision.

Adolescents have unique nutritional needs when compared to young children and adults. As youth go through physical, cognitive, and behavioral development, nutrition needs are dynamic and changing. If these needs go undetected and remain unaddressed, the results can derail physical and social maturation and include life-long effects on health. This comprehensive text offers a multidisciplinary perspective on aspects of adolescent nutrition. Using clinical cases, it covers relevant topics related to adolescent health including normal development, chronic health conditions, and complex biopsychosocial dynamics, among others. The first section of the text contains an overview of adolescent nutrition that is further broken down into more specific topics such as developmental nutrition needs, needs of active youth and athletes and media influences on body image. The next section focuses on health disparities such as culturally appropriate care, health equity, international considerations and food insecurity. The following section specifically addresses eating disorders ranging from anorexia and bulimia to binge eating. Finally, the last section covers additional health considerations such as polycystic ovarian syndrome, teen pregnancy, substance use and gender non-conforming youth. Written by experts in the field, this book is a helpful resource for primary care medical providers, registered dietitians, adolescent medicine specialists as well as advanced practice nurses, physician assistants and athletic trainers.

This volume presents a comprehensive and practical approach to the treatment of suicide and NSSI for adolescents utilizing a mentalizing framework. The beginning of the text provides up-to-date information on the theory of a mentalizing therapy in order to ground the readers in the neuroscientific underpinnings of a mentalizing approach. Next chapters provide information on the fundamental building blocks of a mentalizing therapy at the individual and family level. These chapters provide step-by-step approaches in order to provide examples of the techniques involved in mentalizing treatment that can be employed to address suicidality and NSSI. The next chapter builds on these concepts as the reader learns about mentalizing failures involved in common co-morbidities in adolescents who are experiencing suicidality and/or employing NSSI. The next several chapters cover practical issues related to working within this patient population including the key concept of social systems and connections for both providers and adolescents, the ability of mentalizing theory and therapy to integrate with other effective therapies, how to approach sessions after a suicide attempt, resiliency for patient, family and the provider, along with important self-care for a therapist if a patient commits suicide. The final chapter brings all of the aforementioned elements together in order for the reader to conceptualize employing a mentalizing approach to adolescents and their families when suicide and NSSI concerns are a predominate focus of care. Illustrations of specific therapeutic approaches and a list of resources and guidelines where available are also included. Adolescent Suicide and Self-Injury is an excellent resource for all clinicians working with youths at risk for suicide and/or self-injury, including psychiatrists, psychologists, pediatricians, family medicine physicians, emergency medicine specialists, social workers, and all others.

Adolescent and transitional urology : an introduction -- Anatomical and cystic anomalies -- Stones -- Prune-belly syndrome -- Renal function in adolescents -- Structural anomalies and reconstruction of the ureter -- Vesico-ureteric reflux -- The neuropathic bladder and spina bifida -- Lower urinary tract replacement and reconstruction -- Urinary diversion and undiversion -- Other bladder conditions -- Exstrophy and epispadias -- Cloacal exstrophy -- Posterior urethral valves -- Hypospadias -- Scrotal abnormalities -- The overvirilized female -- The undervirilized male -- Adolescent sexuality and counseling -- Neoplastic disease : outcomes in survivors.

"Adolescence is a challenging stage for all individuals, especially for those with Autism Spectrum Disorder (ASD). Individuals with ASD face increased social isolation and engage in more challenging behaviors during adolescence. They also experience increased mental health challenges including anxiety and depression, and they are among the least likely of any disability group to attend college, be competitively employed, or live independently. At the same time, adolescents with ASD face a major shift in available services and support as they exit the K-12 educational system. The need to present what is known about this group in order to inform clinicians, researchers, and educators cannot be understated. Adolescents with Autism Spectrum Disorder synthesizes current science on adolescents and young adults with ASD in order to inform mental health practitioners and education professionals who work directly with these individuals. While early childhood interventions for ASD have been extensively developed and tested, research on adolescents and young adults with ASD has lagged behind until recently. This comprehensive handbook can be utilized to train students and professionals in applied mental health roles. The handbook includes three sections: Part I reviews diagnosis and treatment of adolescents with ASD; Part II details how to support their educational needs; and Part III discusses special populations including college students and young women. Chapters highlight recommendations for clinicians and include study questions and additional resources."-- Provided by publisher.

Vitamin B3 in health and disease : toward the second century of discovery / Myron K. Jacobson and Elaine L. Jacobson -- Monitoring poly(ADP-Ribosyl)ation in response to DNA damage in live cells using fluorescently tagged macrodomains / Rebecca Smith and Gyula Timinszky -- In vitro techniques for ADP-ribosylated substrate identification / Giovanna Grimaldi, Giuliana Catara, Carmen Valente, and Daniela Corda -- Assessment of intracellular auto-modification levels of ARTD10 using mono-ADP-ribose-specific macrodomains 2 and 3 of murine Artd8 / Mareike Bütepage, Sarah Krieg, Laura Eckei, Jinyu Li, Giulia Rossetti, Patricia Verheugd, and Bernhard Lüscher -- Biochemical and biophysical assays of PAR-WWE domain interactions and production of iso-ADPr for PAR-binding analysis / Zhizhi Wang and Wenqing Xu -- Assays for NAD+-dependent reactions and NAD+ metabolites / Michael B. Schultz, Yuancheng Lu, Nady Braidy, and David A. Sinclair -- Generating protein-linked and protein-free mono-, oligo-, and poly(ADP-ribose) in vitro / Ken Y. Lin, Dan Huang, and W. Lee Kraus -- Methods to study TCDD-inducible poly-ADP-ribose polymerase (TIPARP) mono-ADP-ribosyltransferase activity / David Hutin, Giulia Grimaldi, and Jason Matthews -- Dictyostelium as a model to assess site-specific ADP-ribosylation events / Anna-Lena Kolb, Duen-Wei Hsu, Ana B. A. Wallis, Seiji Ura, Alina Rakhimova, Catherine J. Pears, and Nicholas D. Lakin -- Mono-ADP-ribosylation catalyzed by arginine-specific ADP-ribosyltransferases / Linda A. Stevens and Joel Moss -- Monitoring expression and enzyme activity of ecto-ARTCs / Stephan Menzel, Sahil Adriouch, Peter Bannas, Friedrich Haag, and Friedrich Koch-Nolte -- ADP-ribosyl-acceptor hydrolase activities catalyzed by the ARH family of proteins / Masato Mashimo and Joel Moss -- Mono-ADP-ribosylhydrolase assays / Jeannette Abplanalp, Ann-Katrin Hopp, and Michael O. Hottiger -- Hydrolysis of ADP-ribosylation by macrodomains/ Melanija Posavec Marjanovic, Gytis Jankevicius, and Ivan Ahel -- HPLC-based enzyme assays for sirtuins / Jun Young Hong, Xiaoyu Zhang, and Hening Lin -- Small-molecule screening assay for mono-ADP-ribosyltransferases / Teemu Haikarainen, Sudarshan Murthy, Mirko M. Maksimainen, and Lari Lehtiö -- Simple, sensitive, and generalizable plate assay for screening PARP inhibitors / Ilsa T. Kirby, Rory K. Morgan, and Michael S. Cohen -- Nonlocalized searching of HCD data for fast and sensitive identification of ADP-ribosylated peptides / Thomas Colby, Juan José Bonfiglio, and Ivan Matic -- Quantitative determination of MAR hydrolase residue specificity in vitro by tandem mass spectrometry / Robert Lyle McPherson, Shao-En Ong, and Anthony K. L. Leung -- Detection of ADP-ribosylating bacterial toxins / Chen Chen and Joseph T. Barbieri -- Preparation of recombinant alphaviruses for functional studies of ADP-ribosylation / Rachy Abraham, Robert Lyle McPherson, Easwaran Sreekumar, Anthony K. L. Leung, and Diane E. Griffin -- Monitoring the sensitivity of T cell populations towards NAD+ released during cell preparation / Björn Rissiek, Marco Lukowiak, Friedrich Haag, Tim Magnus, and Friedrich Koch-Nolte -- Identifying target RNAs of PARPs / Florian J. Bock and Paul Chang -- ADPr-peptide synthesis / Hans A. V. Kistemaker, Jim Voorneveld, and Dmitri V. Filippov -- Identifying genomic sites of ADP-ribosylation mediated byspecific nuclear PARP enzymes using click-ChIP / Ryan A. Rogge, Bryan A. Gibson, and W. Lee Kraus -- Methods for using a genetically encoded fluorescent biosensor to monitor nuclear NAD+ / Michael S. Cohen, Melissa L. Stewart, Richard H. Goodman, and Xiaolu A. Cambronne.

Acute Dialysis Quality Initiative (ADQI) / Ronco, C., Kellum, J., Bellomo, R., Mehta, R. -- Implementation of novel biomarkers in the diagnosis, prognosis, and management of acute kidney injury : executive summary from the tenth consensus conference of the Acute Dialysis Quality Initiative (ADQI) / McCullough, P.A., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group -- Diagnosis of acute kidney injury using functional and injury biomarkers : workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference / McCullough, P.A., for the ADQI 10 Workgroup -- Differential diagnosis of AKI in clinical practice by functional and damage biomarkers : workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference / Endre, Z.H., for the ADQI 10 Workgroup -- Use of biomarkers to assess prognosis and guide management of patients with acute kidney injury / Cruz, D.N., for the ADQI 10 Workgroup -- Physiological biomarkers of acute kidney injury : a conceptual approach to improving outcomes / Okusa, M.D., for the ADQI 10 Workgroup -- Pathophysiology of the cardiorenal syndromes : executive summary from the eleventh onsensus conference of the Acute Dialysis Quality Initiative (ADQI) / McCullough, P.A., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group. Pathogenesis of cardiorenal syndrome type 1 in acute decompensated heart failure : workgroup statements from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Haase, M., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group -- Pathophysiology of cardiorenal syndrome type 2 in stable chronic heart failure : workgroup statements from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Cruz, D.N., ; for the Acute Dialysis Quality Initiative (ADQI) Consensus Group -- Cardiorenal syndrome type 3 : pathophysiologic and epidemiologic considerations / Bagshaw, S.M., for the Acute Dialysis Quality Initiative 11 Working Group -- Cardiorenal syndrome type 4 : insights on clinical presentation and pathophysiology from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Tumlin, J.A., for the Acute Dialysis Quality Initiative (ADQI) 11 Consensus Group -- Cardiorenal syndrome type 5 : clinical presentation, pathophysiology, and management strategies from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Mehta, R.L., for the Acute Dialysis Quality Initiative (ADQI) 11 Working Group.

Adrenal disorders are often difficult to diagnose due to common symptoms, and challenging to treat due to common comorbidities. Adrenal Disorders: 100 Cases from the Adrenal Clinic provides a comprehensive, case-based approach to the evaluation and treatment of both common and uncommon adrenal disorders, offering practical, real-world guidance highlighted by detailed laboratory evaluations, computed cross sectional images, nuclear medicine images, and gross pathology photographs. Features 100 two-page cases covering a wide range of common and uncommon adrenal disorders. Includes case report, investigations, treatment, and outcome for each case, plus a case overview with expert advice, take-home points, and references. Organizes comprehensive content by type of disorder, including adrenal masses (benign and malignant), primary aldosteronism, ACTH-independent Cushing syndrome, ACTH-dependent Cushing syndrome, adrenal carcinoma, pheochromocytoma, adrenal and ovarian hyperandrogenism, and adrenal disorders in pregnancy. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices-- Provided by publisher.

1. Introduction -- 2. Diagnostic assessment -- 3. Diagnostic instruments -- 4. Treatment -- 5. Treatment: coaching adults with ADHD -- 6. Setup and organization of a specialist department.

This updated volume provides a clinical based overview of the assessment and treatment of ADHD in adults by a clinical researcher with extensive experience. Its practical focus allows each chapter to answer common questions encountered within clinical practice. Differential diagnosis of ADHD is also discussed in relation to comorbidity with bipolar disorder, borderline personality disorder, chronic fatigue syndrome, and chronic delayed sleep phase. Adult ADHD: Diagnostic Assessment and Treatment, fourth edition aims to help readers identify ADHD effectively and put in place suitable treatments. The book is relevant for psychiatrists, neurologists, and healthcare professionals involved in the diagnosis and treatment of adult ADHD.

"This text reviews the anatomy and physiology of neuromodulation for treatment of various pathology of the human body, with specific emphasis on sacral neuromodulation for bladder and bowel dysfunction in the adult and pediatric populations. In addition to historical overview of the various methods of neuromodulation, present day applications will be discussed as well as possible future directions for use. Adult and Pediatric Neuromodulation will be of great value to medical professionals who are interested in the use of neuromodulation as a possible therapy option for their patients, particularly when other traditional or medical management options have failed. Each chapter is written by experts in the topic of various modalities of neuromodulation."-- Provided by publisher.

This book elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.

Part 1. Introduction to adult congenital heart disease -- Part 2. Specific lesions -- Part 3. General management issues of adult congenital heart disease.

This book describes the most popular topics concerning adult congenital heart disease (ACHD), especially focusing on indications and re-intervention procedures for some major ACHDs. Thanks to advances in medical and surgical therapy for congenital heart disease over the last half century, many patients who underwent surgical correction reached adulthood. However, as can be seen from the explosive increase in the number of ACHD patients, postoperative residua and sequelae have also become apparent. The purpose of this book is to highlight complicated problems in connection with ACHD, including its present status, as well as methods for its management including medical and surgical treatment. The content primarily focuses on two areas - general information for cardiologists, and information on re-intervention for interventionists and cardiac surgeons -, setting it apart from the majority of books on congenital heart disease.

There is an evident practice gap in education of general adult cardiologists on long-term management of congenital heart disease (CHD). The goal of this book is to help general cardiologists, but also pediatricians and related care providers in the management and diagnosis of adult CHD. Adult Congenital Heart Disease in Clinical Practice provides clear, practical advice on adult CHD for the busy fellow, resident and practicing clinician. It includes training and revision material to assist learning and is formatted in such a way as to provide short, concise content designed for easy recall of salient facts.

This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.

This book is intended to offer a “virtual fellowship” in hip surgery that will give readers the opportunity to join distinguished hip surgeons in the operating room, learning key points and solutions to technical difficulties from the beginning to the end of 100 surgical cases. All of these cases have been carefully selected by renowned orthopaedists who work at the world’s top centers and perform surgery based on evidence. To facilitate quick learning, the cases are presented using a uniform template, guiding the reader from clinical evaluation and preoperative planning, through the decision-making process, to the surgical procedure and the final outcome. At the end of each case, the editor invites the surgeon to answer specific questions in order to further elucidate crucial issues with reference to current evidence. The book is divided into four sections: conservative hip surgery, primary hip arthroplasty, complex hip arthroplasty, and revision arthroplasty. It will be of value across the world to specialist hip surgeons and surgeons in training who are interested in hip surgery.

"As knee replacement surgeries continue to grow in number worldwide, the need for an authoritative and comprehensive reference in this key area is a must for today's orthopaedic surgeon. The Adult Knee: Knee Arthroplasty, Second Edition, brings together the knowledge and expertise of internationally recognized experts in the field in one convenient volume. Covers knee biomechanics relevant to knee arthroplasty, alternatives to knee arthroplasty to alleviate arthritis, and primary total knee arthroplasty, including perioperative issues. Discusses complications including stiff knee, periprosthetic fractures, and instability, revision total knee arthroplasty, and management of infections in total knee replacement"-- Provided by publisher

Defining Adult Lumbar Scoliosis -- Imaging Adult Lumbar Scoliosis -- Radiographic Parameters for Adult Lumbar Scoliosis -- Patient Reported Outcome Measures Available for Adult Lumbar Scoliosis -- Impact of Depression on the Treatment of Adult Lumbar Scoliosis -- Pre-Operative Clinical Evaluation of Adult Lumbar Scoliosis -- Non-Operative Management of Adult Lumbar Scoliosis -- Surgical Alignment Goals for Adult Lumbar Scoliosis -- Intra-Operative Management of Adult Lumbar Scoliosis -- Biologics for Adult Lumbar Scoliosis -- Assessing the Need for Decompression for Adult Lumbar Scoliosis -- Minimally Invasive Techniques for Adult Lumbar Scoliosis -- Anterior Column Release for Adult Lumbar Scoliosis -- Anterior Column Support Options for Adult Lumbar Scoliosis -- Releases and Osteotomies Used for the Correction of Adult Lumbar Scoliosis -- Distal Fixation for Adult Lumbar Scoliosis: Indications and Techniques -- Diagnosis and Classification of Proximal Junctional Kyphosis and Proximal Junctional Failure -- Prevention Strategies for Proximal Junctional Kyphosis -- Complications Following Surgical Intervention for Adult Lumbar Scoliosis -- Peri-Operative Patient Management of Adult Lumbar Scoliosis -- Patient Reported Outcomes Following the Treatment of Adult Lumbar Scoliosis -- Health Economic Value of the Treatment for Adult Lumbar Scoliosis -- Future Directions for Adult Lumbar Scoliosis.

Simple protocol to isolate, characterize, and expand dental pulp stem cells / Federica Di Scipio, Andrea Elio Sprio, Maria Elisabetta Carere, Zhiqian Yang, and Giovanni Nicolao Berta -- Derivation of mesenchymal stem cells from embryonic stem cells : a non-variable and inexhaustive source of adult stem cells / Glen Lester Sequiera, Niketa Sareen, Ejlal Abu El-Rub, and Sanjiv Dhingra -- Compact bone-derived multipotent mesenchymal stromal cells (MSCs) for the Tteatment of Sjogren's-like disease in NOD mice / Ghada Abu Elghanam, Younan Liu, Saeed Khalili, Dongdong Fang, and Simon D. Tran -- Manipulating the proliferative potential of cardiomyocytes by gene transfer / Giulia Prosdocimo and Mauro Giacca -- Assessment of energy metabolic changes in adipose tissue-derived stem cells / Ghazaleh Hajmousa and Martin C. Harmsen -- Isolation and in vitro characterization of epidermal stem cells / Kasper S. Moestrup, Marianne S. Andersen, and Kim B. Jensen -- Endothelial progenitor cells : procedure for cell isolation and applications / Garikipati V.N. Srikanth and Raj Kishore -- Therapeutic application of placental mesenchymal stem cells reprogrammed neurospheres in spinal cord injury of SCID / Vikram Sabapathy, Franklin Jebaraj Herbert, and Sanjay Kumar -- Therapeutic application of human wharton jelly mesenchymal stem cells in skin injury of SCID / Vikram Sabapathy, Balasubramanian Sundaram, and Sanjay Kumar -- Isolation, characterization, and expansion of cancer stem cells / Luke A. Torre-Healy, Artem Berezovsky, and Justin D. Lathia -- Cardiac progenitor cell extraction from human auricles / Paolo Di Nardo and Francesca Pagliari -- Isolation and culture of satellite cells from mouse skeletal muscle / Antonio Musarò and Silvia Carosio -- Isolation of stromal stem cells from adipose tissue / Maria Prat, Francesca Oltolina, Silvia Antonini, and Andrea Zamperone -- Human-induced pluripotent stem cell-derived mesenchymal stem cells as an individual-specific and renewable source of adult stem cells / Glen Lester Sequiera, Sekaran Saravanan, and Sanjiv Dhingra -- Simplified and systematic method to isolate, culture, and characterize multiple types of human dental stem cells from a single tooth / Mohammed Bakkar, Younan Liu, Dongdong Fang, Camille Stegen, Xinyun Su, Murali Ramamoorthi, Li-Chieh Lin, Takako Kawasaki, Nicholas Makhoul, Huan Pham, Yoshinori Sumita, and Simon D. Tran -- Measurement of autophagy by flow cytometry / Silvia Zappavigna, Angela Lombardi, Gabriella Misso, Anna Grimaldi, and Michele Caraglia -- Echocardiography-guided intramyocardial injection method in a murine model / Kay Maeda, Rick Seymour, Marc Ruel, and Erik J. Suuronen -- Noninvasive assessment of cell fate and biology in transplanted mesenchymal stem cells / Federico Franchi and Martin Rodriguez-Porcel -- Methods for long-term storage of murine bone marrow-derived mesenchymal stem cells / Niketa Sareen, Ejlal Abu-El-Rub, Glen Lester Sequiera, Meenal Moudgil, and Sanjiv Dhingra -- Therapeutic application of adult stem cells in the heart / Taylor A. Johnson and Dinender K. Singla -- Patient-derived and intraoperatively formed biomaterial for tissue engineering / Shalmli U. Joshi, Rares O. Barbu, Melissa Carr-Reynolds, Brian Barnes, and Syam P. Nukavarapu -- Three-dimensional printed scaffolds with multipotent mesenchymal stromal cells for rabbit mandibular reconstruction and engineering / Dongdong Fang, Michael Roskies, Mohamed-Nur Abdallah, Mohammed Bakkar, Jack Jordan, Li-Chieh Lin, Faleh Tamimi, and Simon D. Tran -- Optimal environmental stiffness for stem cell mediated ischemic myocardium repair / Honghai Liu, Christian Paul, and Meifeng Xu -- Assessment of MiRNA regulation of endothelial progenitor cell mediated angiogenesis / Darukeshwara Joladarashi and Prasanna Krishnamurthy -- Stem cell exosomes : cell-freetherapy for organ repair / Mohsin Khan and Raj Kishore.

Speakers at the symposium -- Stem cells in adult intestine / Feng, J., Sperka, T. -- Molecular mechanisms of muscle stem cell aging / Schwërer, S., Tümpel, S. -- Mechanism of functional alterations in hematopoietic stem cell aging / Morita, Y. -- The microenvironment, aging, and disease / Geiger, H. -- Sestrins in aging and metabolism / Tang, D., Tao S. -- Telomeres and stem cell aging / Felix, D.A. -- DNA damage and checkpoint responses in adult stem cells / Romanov, V., Shukla, A., Ju, Z.

This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.

Anatomy -- Ideal Shape of Umbilicus -- Classification -- History -- Position of Umbilicus -- Umbilical Reconstructive Techniques -- Melanoma -- Complications and Outcome.

After introductory chapters devoted to the safe production and distribution of vaccines, the book addresses the question of adult vaccination in the framework of a life-course approach to vaccination. It presents the proceedings of multidisciplinary expert discussions with an excellent summary of the current state of knowledge on adult vaccination in various diseases, as well as an overview of the professionals involved and the obstacles to achieving greater vaccine uptake, and how these may be addressed. The book systematically discusses the major vaccine-preventable diseases, as well as regulatory issues in vaccine provision, and presents the results of an expert meeting designed to identify the obstacles to vaccination, and solutions for addressing these barriers. It goes on to extend the discussion beyond the traditional boundaries of human health to encompass the “one health” concept. The book is intended for all those with an interest in vaccination, including physicians (from a wide range of disciplines including geriatrics/gerontology, infectious diseases, pediatrics, internal medicine, and other non-organ specialties), other healthcare professionals, pharmacists, representatives of the pharmaceutical industry and regulatory bodies (EMEA, national authorities), policymakers, the media and the general public.

Substitution and adulteration in traded herbal raw material are common practice in the herbal industry due to the extinction of required species, deforestation and incorrect taxonomical identification. Herbalists have adopted methods to create high quality adulteration which cannot be detected without performing microscopic examination or chemical analysis. It is difficult to establish specific quality control standards due to the complex nature and innate unpredictability of the chemical constituents of medicinal herbs.The main parameters for measurement and adulteration prevention in medicinal herbs are morphological and microscopic investigation, chemical profiling and DNA barcoding. The need for highly sensitive and more effective approaches for the authentication of medicinal herbs is necessary in order to promote the acceptance of herbal products. Adulteration In Traditional Medicinal Herbs is aimed at promoting awareness of adulteration in traditional herbal medicines for the worldwide scientific community. Parameters are established for the prevention of adulteration through classical and modern scientific tools. Valuable case studies are presented based on ethno-medicinal surveys performed in many herbal markets in Pakistan. Collections of various samples were obtained from these shops then compared with the original plants collected from field. Various phytochemical, organoleptic and DNA barcoding techniques were used in order to detect adulteration in the marketed herbal samples. This book is the first of its kind and is aimed at helping the scientific community to identify particular medicinal plants which are facing adulteration problems in herbal markets and to estimate the extent of adulteration and substitution in commonly used medicinal herbs.

This volume gives an overview on the currently debated ethical issues regarding advance directives from an international perspective. It focuses on a wider understanding of the known and widely accepted concept of patient self-determination for future situations. Although advance directives have been widely discussed since the 1980s, the ethical bases of advance directives still remain a matter of heated debates. The book aims to contribute to these controversial debates by integrating fundamental ethical issues on advance directives with practical matters of their implementation. Cultural, national and professional differences in how advance directives are understood by health care professions and by patients, as well as in laws and regulations, are pinpointed.

This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.

This book provides novel arthroscopy techniques and applications to clinical practitioners, including sports medicine therapeutics, orthopaedic surgeons, specialist training candidates, rehabilitation clinicians. Small incisions per minimally invasive surgery using a camera mounted on a thin tube to visualize, repair and reconstruct joint-associated structures are accepted and welcomed by the sports medicine field. Arthroscopy technique as a minimally invasive surgical method, in Orthopeadics is not only for the treatment of intra-articular diseases but also an advanced conception for treatment of extra-articular diseases and peri-articular fractures. After performing years of arthroscopy, authors intend to provide an elite technique demonstration of each procedure, including indications, technique, complications, and results. There are three main parts of the book, including the extra-articular application of arthroscopy techniques, arthroscopic minimally invasive techniques for the treatment of intra-articular fractures, and Innovative technology for repair and reconstruction of bone and joint injuries. Key technical points and experience of arthroscopic repair of joint injuries, dislocation of joints, fixation of the intra-articular fractures, ligament release for limbs are illustrated. Special situations such as congenital torticollis, deltoid contracture, gluteal muscle contracture, bone grafting, removal of locking plate and screw and benign tumors treatment are also included.

Step by step, you'll hone your ability to perform effective health assessments, obtain valid data, interpret the findings, and recognize the range of conditions that can be indicated by specific findings to reach an accurate differential diagnosis. You'll have coverage of 170 conditions and symptoms across the lifespan at your fingertips.

"The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.

1. Frotiers for bulk nanostructured metals in biomedical applications -- 2. Stimuli-responsive materials used as medical devices in loading and releasing of drugs -- 3. Recent advances with liposomes as drug carriers -- 4. Fabrication, properties of nanoshells with controllable surface charge and its applications -- 5. Chitosan as an advanced healthcare material -- 6. Chitosan and low molecular weight chitosan: biological and biomedical applications -- 7. Anticipating behaviour of advanced materials in healthcare -- 8. Label-free biochips -- 9. Polymer MEMS sensors -- 10. Assembly of polymers/metal nanoparticles and their applications as medical devices -- 11. Combination of molecular imprinting and nanotechnology: beginning of a new horizon -- 12. Prussian blue and analogues: biosensing applications in health care -- 13. Efficiency of biosensors as new generation of analytical approaches at the biochemical diagnostics of diseases -- 14. Nanoparticles: scope in drug delivery -- 14. Smart polypeptide nanocarriers for malignancy therapeutics -- Index.

"Advances in Cardiac Imaging presents the latest information on heart disease and heart failure, major causes of death among western populations. In addition, the text explores the financial burden to public healthcare trusts and the vast amount of research and funding being channeled into programs not only to prevent such diseases, but also to diagnose them in early stages. This book provides readers with a thorough overview of many advances in cardiac imaging. Chapters include technological developments in cardiac imaging and imaging applications in a clinical setting with regard to detecting various types of heart disease"--Provided by publisher.

Part 1 Introduction -- Part 2 Systems of Care -- Part 3 Effective High-Performance Team Dynamics -- Part 4 The Systematic Approach -- Part 5 The ACLS Cases: Respiratory arrest case ; Acute coronary syndrome case ; Acute stroke case ; Cardiac arrest: VF/pulseless VT case ; Cardiac arrest: pulseless electrical activity case ; Cardiac arrest: asystole case ; Brachycardia case ; Tachycardia: stable and unstable ; Immediate post-cardiac arrest care case -- Appendix -- Index.

Part 1: Overview of ACLS. Introduction ; Systems of care ; Systematic approach -- Part 2: Preventing arrest. Recognition: signs of clinical deterioration ; Acute coronary syndromes ; Acute stroke ; Bradycardia ; Tachycardia: stable and unstable -- Part 3: High-performance teams. High-performance team roles and dynamics ; Respiratory arrest ; Cardiac arrest: VF/pVT ; Cardiac arrest: PEA and asystole ; Cardiac arrest: selected special situations ; Post-cardiac arrest care -- Appendices: Testing checklists and learning station checklists ; ACLS pharmacology summary table ; Science summary table ; Glossary.

Endoscopic Instruments -- Difficult Polpys: Conventional methods -- Endoscopic Mucosal Resection (EMR) -- Endoscopic Submucosal Dissection (ESD) -- Combined Endoscopic and Laparoscopic Surgery (CELS) -- Colonic Stenting -- Endoscopic Treatment of Perforations of Fistulas.

History of Colonoscopy -- Anatomic Basis of Colonoscopy -- Colonoscopy Photo Atlas -- How to Achieve High Rates of Bowel Preparation Adequacy -- Patient comfort during colonoscopy -- VTE Prophylaxis: How to optimize patients on anticoagulation and avoid infectious complications -- Endoscopic Equipment and Instrumentation -- Basic Colonoscopic Techniques to Reach the Cecum -- Basic Colonoscopic Interventions: Cold, Hot Biopsy Techniques, Submucosal Injection, Clip Application, Snare Biopsy -- Current Guidelines for Colonoscopy -- Difficult Colonoscopy: tricks and new techniques for getting to the cecum -- How to recognize, characterize, and manage premalignant and malignant colorectal polyps -- Detection: (CQI) Quality measures and tools for improvement -- Advanced endoscopic imaging: polyps and dysplasia detection -- Endoscopic Mucosal Resection (EMR) -- Endoscopic Mucosal Dissection -- Applications of intra-operative endoscopy -- Combined Endoscopic and Laparoscopic Surgery (CELS) -- Endoluminal Colorectal Stenting -- How to Avoid Complications/Treatment of Endoscopic Complications -- Alternative Colorectal Imaging -- Current Endoluminal Approaches: Transanal Endoscopic Microsurgery, Transanal Minimally Invasive Surgery and Transanal Total Mesorectal Excision.

In this book, leading international specialists in the field join forces to discuss topics, issues, and approaches that are of key importance in the optimal treatment of lumbar degenerative disk disease. The coverage is wide ranging, from current understanding of physiopathology and genetics and modern imaging techniques through to the diverse minimally invasive, non-fusion, and fusion surgical techniques. Detailed attention is drawn to the most important aspects to be considered when approaching the patient and making treatment decisions. The role of conservative management is appraised, and surgical techniques and their indications are carefully described. Emphasis is placed on the importance of sagittal balance for treatment success. Among the various other subjects covered are psychosocial issues, legal aspects, outcome evaluation, and the relative merits of evidence-based medicine and individual experience. In the concluding section, some of the top specialists from across the world reflect on the lessons that they have learned during lifetimes in spinal surgery. Advanced Concepts in Lumbar Degenerative Disk Disease is intended as the definitive book on this important subject. It will be an instructive and fascinating source of information for all spine surgeons and other spine care providers.

In this book, international experts present up-to-date techniques of otoplasty in which they have extensive personal experience. Both new and modified procedures are described with the aid of a wealth of high-quality illustrations. In addition to these detailed descriptions, ear embryology and anatomy, psychological issues, postoperative care, possible risks and complications, and outcomes are extensively covered in order to provide the reader with a state of the art account of all aspects of cosmetic otoplasty.

Learn to effectively address life-threatening and potentially life-threatening patient conditions, with Advanced Critical Care Nursing, 2nd Edition. Endorsed by the American Association of Critical-Care Nurses (AACN), this comprehensive, nursing-focused text centers on the clinical reasoning process as it helps you comprehend, analyse, synthesize, and apply advanced critical care knowledge and concepts. The book is organized within the structure of body systems along with synthesis chapters that address patient conditions involving multiple body systems. Numerous illustrations and graphs plus unfolding case studies further aid your understanding and help you apply text content. In all, Advanced Critical Care Nursing is the must-have resource dedicated to helping you oversee or care for critical care patients in any practice setting. -- Provided by publisher.

The physical basis of total internal reflection fluorescence (TIRF) microscopy and its cellular applications -- Two-photon excitation microscopy and its applications in neuroscience -- Live spheroid formation recorded with light sheet-based fluorescence microscopy -- Fluorescence microscopy-based RNA interference screening -- Fluorescence resonance energy transfer microscopy (FRET) -- Localizing protein-protein interactions in living cells using fluorescence lifetime imaging microscopy -- Analysis of biomolecular dynamics by FRAP and computer simulation -- Fluorescence correlation spectroscopy -- Homo-FRET imaging highlights the nanoscale organization of cell surface molecules -- Practical structured illumination microscopy -- 4Pi microscopy of the nuclear pore complex -- Application of STED microscopy to cell biology questions -- Three-dimensional photoactivated localization microscopy with genetically expressed probes -- Direct stochastic optical reconstruction microscopy (dSTORM) -- Optogenetics: Optical control of a photoactivatable Rac in living cells.

The ability to precisely modify the genome with high efficiency in a directed manner is dependent on generating and exploiting a double-strand break in DNA. The tools available to generate double-strand breaks include the recombinases and resolvases, the phage integrases, the homing endonucleases, zinc finger nucleases, transcription activator-like effector nucleases, and the CRISPR/Cas9 system, the most recently developed tool. These tools allow for in-depth studies of the function of genes and genome structure, the generation of organisms bearing economically important bio-synthetic pathways, and the development of novel gene and cell therapies for addressing previously untreatable diseases. Taking full advantage of each tool and knowing when to use each one requires a thorough understanding of how the tool functions. For most of the genome engineering toolkit, this understanding has been achieved. The CRISPR/Cas9 system, however, has been assumed to function in the same manner as the zinc finger and transcription activator-like effector nucleases despite generating blunt-end double-strand breaks rather than staggered breaks. This difference is important to understanding how Cas9-mediated double-strand breaks are repaired, and, thus, how best to exploit these breaks for genome engineering. This thesis illustrates the importance understanding how each genome engineering tool functions in developing advantageous methods for gene and cell therapies.

1 Advanced Glaucoma Surgery: An Overview -- 2 Trabecular Micro-bypass Stent for the Treatment of Co-existent Cataract and Mild Open-Angle Glaucomas -- 3 Trabectome-Mediated Ab Interno Trabeculectomy for Secondary Glaucoma or as a Secondary Procedure -- 4 Lens Extraction in Angle Closure Glaucoma -- 5 Gonioscopy Assisted Transluminal Trabeculotomy (GATT) for the Treatment of Adult and Developmental Glaucomas -- 6 Ab-Interno Subconjunctival Glaucoma Implant for Advanced Open-Angle Glaucomas -- 7 Nonpenetrating Glaucoma Surgery -- 8 Endoscopic Cyclophotocoagulation in the Treatment of Plateau Iris and Angle Closure Glaucomas -- 9 Ex-PRESS Miniature Glaucoma Shunt for the Treatment of Uveitic Glaucomas -- 10 Surgical Management of Normal Tension Glaucoma -- 11 Glaucoma Drainage Implant Surgery Combined with Pars Plana Vitrectomy and KPro Implantation -- 12 The Modified Schocket Procedure -- 13 Ab-interno Bleb Needling -- 14 Drainage of Choroidal Effusions -- 15 Surgical Management of Malignant Glaucoma -- Supplemental Video Table of Contents -- 1. Video 3.1. Trabectome Procedure with Goniosynechiolysis -- 2.Video 5.1. Gonioscopy Assisted Transluminal Trabeculotomy (GATT) -- 3.Video 6.1. Xen Gel implantation -- 4. Video 7.1. Non-Penetrating Glaucoma Surgery -- 5. Video 9.1. Ex-Press Shunt Implantation -- 6. Video 10.1. Trabeculectomy with adjunctive Mitomycin-C -- 7. Video 11.1. Glaucoma Drainage Implant Surgery Combined with Pars Plana Vitrectomy and KPro Implantation -- 8. Video 12.1. Modified Schocket Procedure -- 9. Video 13.1. Ab-Interno Trabeculectomy Revision -- 10. Video 15.1. .

Chapter 1. Migraine and Headache: General -- Chapter 2. Refractory(Difficult to Treat) Headache -- Chapter 3. Child and Adolescent Headaches -- Chapter 4. Cluster Headache. Chapter 5. Psychological Comorbidities -- Chapter 6. Case Studies -- Chapter 7. Miscellaneous.

"This textbook is a tool that is used to help students learn advanced health assessment techniques that focus on the assessment and diagnosis of common disorders of the systems of the body. Most Medical Schools, Physician Assistant School and Schools of Nursing have Advanced Practice curriculums which require an Advanced Health Assessment Course. Most courses are designed to provide students and young practitioners with a glimpse into the minds of experienced clinicians who are assessing and solving therapeutic problems on a daily basis. These students and new practitioners play a vital role in the health assessment of the public. They must know that the focus of the assessment is intense and complete and that the appropriate diagnostic intervention is selected based on solid evidence/clues from the health assessment, which will ensure that the right intervention is ordered for the right patient at the right time with due consideration of costs. It also ensures that the patient knows how, why and when to use the prescribed intervention. This textbook has met this benchmark and will continue to do so with a current edition"-- Provided by publisher.

"Advanced Healthcare Nanomaterials summarises the current status of knowledge in the fields of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, up and coming bio-engineering devices"-- Provided by publisher.

This book describes how to monitor and optimize cardiovascular dynamics using advanced hemodynamic monitoring in perioperative and intensive care medicine. The book outlines basic skills of hemodynamic monitoring, different techniques including invasive, minimally invasive, and non-invasive methods, and algorithms and treatment strategies for perioperative goal-directed hemodynamic therapy in different groups of surgical patients. Thus, the book reflects current diagnostic and therapeutic approaches in perioperative and intensive care medicine. All sections of this book have a learning-oriented style and are illustrated with tables and figures summarizing the main content. The volume is addressed both to specialists and residents using advanced hemodynamic monitoring; it reflects indications and limitations of current monitoring tools and discuss therapeutic strategies. It also helps readers to integrate new knowledge on monitoring of cardiovascular dynamics into clinical practice.

This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science. .

Test equipment in biology laboratories -- Automation software (acquisition, control and analysis concepts) -- Digital Image Processing (F. Sacerdoti) -- Statistic Analysis.-€ Cell identification -- Cell classification & Counting.-€ Cell aggregation -- Skin and body analysis (F. Melchi & F.M. Sacerdoti) -- Space or Space Simulation equipments -- Off-the-shelf Analysis Software. Commercial & Open Source -- Commercial Test Equipment -- Best practices.

Laser Fundamental Principles / Georgios E Romanos -- Lasers and Wound Healing / Georgios E Romanos -- Lasers in Oral Surgery / Georgios E Romanos -- Lasers and Bone Surgery / Georgios E Romanos -- Lasers in Periodontology / Georgios E Romanos -- Lasers and Implants / Georgios E Romanos -- Photodynamic Therapy in Periodontal and Peri-Implant Treatment / Anton Sculean, Georgios E Romanos -- Understanding Laser Safety in Dentistry / Vangie Dennis, Patti Owens, Georgios E Romanos -- Appendix A: Suggested Reading -- Appendix B -- Index.

Since the publication of the first edition of Urethral Reconstructive Surgery, important refinements have been added to the urologic surgical armamentarium. Extensively revised and updated, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition guides urologists in a practical manner on how to evaluate and manage complex urethral and male genital reconstructive challenges. Chapters have been added on wound healing, synchronous urethral strictures, non-transecting anastomotic urethroplasty (including muscle and vessel sparing), overlapping buccal grafts, male urethral slings, genital skin grafting, Peyronies surgery, priapism, pediatric strictures, and prosthetics. Such chapters greatly strengthen the overall appeal of the book. The volume closes with a new comprehensive appendix of preferred instruments. With broad contributions by international authorities in reconstructiveurologic surgery, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition is a valuable resource for all urologists, from residents to reconstructive surgeons.

Physiology and function of the gastrointestinal and hepatobiliary tract -- Dietary components relevant to gastrointestinal health -- Gastrointestinal disorders -- Hepatobiliary disorders.

Background to undernutrition -- Identification of undernutrition -- Nutrition requirements in nutrition support -- Nutritional interventions to prevent and treat undernutrition -- Undernutrition and nutritional support in clinical specialities.

"This addition to the British Dietetic Association Advanced Nutrition and Dietetics book series is written for clinicians and researchers who work with any aspect of obesity and its comorbid conditions. Featuring contributions from leading researchers and practitioners from around the globe Advanced Nutrition and Dietetics in Obesity offers a uniquely international perspective on what has become a worldwide public health crisis. Chapters cover a full range of new ideas and research on the underlying drivers of obesity in populations including discussions on the genetic and clinical aspects of obesity, along with expert recommendations on how to effectively manage and prevent this chronic and persistent disease. Providing a comprehensive overview of the key literature in this field, Advanced Nutrition and Dietetics in Obesity is an invaluable resource for all those all those whose work should or does embrace any aspect of obesity"--Provided by publisher.

Cancer prevention, screening, and early detection -- Genetic risk -- Cancer diagnosis and staging -- Chemotherapy, targeted biotherapy, and molecular therapy -- Surgery -- Radiation therapy -- Blood and marrow stem cell transplantation -- Complementary and integrative therapies -- Clinical research -- Pain, fatigue, and cognitive impairment -- Myelosuppression -- Cardiac and pulmonary toxicities -- Gastrointestinal, genitourinary, and hepatic toxicities -- Neurologic, ocular, and dermatologic toxicities -- Metabolic emergencies -- Structural oncologic emergencies -- Psychosocial management -- Cancer survivorship -- Palliative and end-of-life care -- Roles of the oncology advanced practice nurse -- Professional practice of advanced practice nurses -- Test questions.

pt. A. Structure and mechanisms -- pt. B. Reactions and synthesis.

This course book gives guidance on life-threatening emergencies in children. It covers recognition of the seriously ill child, basic life support, treatment of shock, in a structured approach to the seriously injured child.

"Pediatric healthcare experts agree that the health care needs of children are vastly different from those of adults. From infancy through adolescence, a child experiences many dramatic anatomical, physiologic, psychosocial, developmental, and cognitive changes. Thus, it is critical for the pediatric health care provider to possess specialized knowledge and skills to accurately assess children during health and illness. Concepts related to the health assessment and physical examination of adults cannot be universally applied to the care of children; children are not simply little adults"-- Provided by publisher.

A high-yield, clinically-relevant resource for understanding the epidemiology, pathophysiology, assessment, and management of a wide variety of perioperative emergencies. Each chapter opens with a clinical case, followed by a discussion of the relevant evidence. Case-based learning discussion questions, which can be used for self-assessment or in the classroom, round out each chapter. This work is an ideal resource for trainees, clinicians, and nurses who work in the perioperative arena, from the operating room to the postoperative surgical ward.

This advanced physiology and pathophysiology text is designed to address the specific learning needs of future nurse practitioners, physician assistants, and other advanced healthcare providers caring for patients across the lifespan. Focusing on practical applications of physiology, it facilitates in-depth understanding of important pathophysiological concepts as they relate to major disorders commonly seen in clinical practice and includes comprehensive pediatric and geriatric considerations. This knowledge is crucial to providing the foundation required to be an informed and confident clinical decision maker.

This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society for Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resource for endocrinology specialty trainees, general practitioners, medical and nursing students, expert patients and nurses working in specialties such as fertility, osteoporosis, oncology, obesity, urology and gynaecology, who look after patients with endocrine-related disorders. This volume includes 13 sections and 69 chapters providing a comprehensive overview of adult and paediatric endocrinology but also a section on advanced practice, role development and nursing research. It has been written by an international team of more than 100 eminent nurses, physicians, surgeons, psychologists and other healthcare professionals, which makes this book a valuable resource for any multidisciplinary team. Many patient advocacy groups have contributed with case studies which emphasises the close working relationships with patients.

This textbook explores issues central to the provision of recovery-orientated care based on ethical principles and human rights perspectives. Written by academics and nurse practitioners, this comprehensive text draws together theory, research and practice to map the landscape of Advanced Practice in Mental Health Nursing (APMHN) in Europe. Underpinned by a rights- and relational- based approach to care, the textbook is organized around six themes: theoretical and historical perspectives; foundations for collaborative working; therapeutic engagement in different contexts; beyond the clinical dimension of the APMHN role; advancing the evidence-based practice agenda and emerging issues and challenges. Each theme consists of a number of chapters that are designed to address different aspects of APMHN. With a focus on illuminating the collaborating aspect of their role and advancing nurses competencies, debates and guidance are provided in areas such as therapeutic alliance, assessment, care-planning, mental health promotion, family work, trauma, diversity and culture, spirituality, risk and uncertainty, and prescribing. In addition to addressing the leadership, education and advocacy role, specific chapters explore the APMHN role in linking evidence to practice, in the participatory generation of evidence and maintaining professional competence. With a focus on future challenges and opportunities the textbook concludes with discussion on issues, such as eMental Health and future challenges and possibilities facing APMHNs, including challenges in informing policy, democratizing services, working across service and disciplinary boundaries, collaboratively shaping the evidence agenda, as well sustaining their role into the future. Within the book theoretical debate is grounded in case studies and/or examples from across Europe. This textbook is especially relevant to Mental Health Nurses undertaking studies at the Advanced Practice level. It is also suited to all Mental Health Nurses studying at post-graduate level who wish to advance their practice irrespective of the country. Educators, researchers and policy-makers involved in the area of Mental Health and Advanced Nursing Practice along with people with lived experiences will find the text of relevance.

"Advanced Practice Nursing: Essential Knowledge for the Profession, Third Edition is a core advanced practice text used in both Master's Level and DNP programs. The Third Edition is a unique compilation of existing chapters from a variety of high-level Jones & Bartlett Learning works creating a comprehensive and well-rounded resource for the advanced practice nursing student. Similar to the previous edition, The Third Edition is framed around the AACN's Master's Essentials as well as the Essentials for Doctoral Education featuring the most up-to-date content on each set of Essentials. Throughout the Third Edition the authors address the rapid changes in the health care environment with a special focus on health care finance, electronic health records, quality and safety as well as emerging roles for the advanced practice nurse. Patient care in the context of the advanced nursing role is also discussed."--Publisher's website.

Advanced Practice Nursing: Essential Knowledge for the Profession, Fourth Edition is a core advanced practice text used in both Master's Level and DNP programs. Similar to the previous edition, The Fourth Edition is framed around the AACN's Master's Essentials as well as the Essentials for Doctoral Education featuring the most up-to-date content on each set of Essentials. Throughout the Fourth Edition the authors address the rapid changes in the health care environment with a special focus on health care finance, electronic health records, quality and safety as well as emerging roles for the advanced practice nurse. Patient care in the context of the advanced nursing role is also discussed.

Unit 1: The evolution of advanced practice -- Advanced practice nursing: doing what has to be done -- Emerging roles of the advanced practice nurse -- Role development: a theoretical perspective -- Educational preparation of advanced practice nurses: looking to the future -- Global perspectives on advanced nursing practice -- Unit 2: The practice environment -- Advanced practice nurses and prescriptive authority -- Credentialing and clinical privileges for the advanced practice registered nurse -- The kaleidoscope of collaborative practice -- Participation of the advanced practice nurse in health plans and quality initiatives -- Public policy and the advanced practice registered nurse -- Resource management -- Mediated roles: working with and through other people -- Unit 3: Competency in advanced practice -- Evidence-based practice -- Advocacy and the advanced practice registered nurse -- Case management and advanced practice nursing -- The advanced practice nurse and research -- The advanced practice nurse: holism and complementary and integrative health approaches -- Basic skills for teaching and the advanced practice registered nurse -- Culture as a variable in practice -- Conflict resolution in advanced practice nursing -- Leadership for APNs: if not now, when? -- Information technology and the advanced practice nurse -- Writing for publication -- Unit 4: Ethical, legal, and business acumen -- Measuring advanced practice nurse performance: outcome indicators, models of evaluation, and the issue of value -- Advanced practice registered nurses: accomplishments, trends, and future development -- Starting a practice and practice management -- The advanced practice nurse as employee or independent contractor: legal and contractual considerations -- The law, the courts, and the advanced practice registered nurse -- Malpractice and the advanced practice nurse -- Ethics and the advanced practice nurse.

Explore effective ways to enhance the wellness and independence of older adults across the wellness-illness continuum, including acute, primary, and long-term care. From an overview of the theories of aging and assessment through the treatment of disorders, including complex illnesses, this evidence-based book provides the comprehensive gerontological coverage you need to prepare for your role as an Advanced Practice Nurse. You'll be prepared for boards and for practice. -- From product description.

This book is distinctive in its focus on Advanced Practice Nursing leadership globally. It has a unique structure, first highlighting global APN leadership and then including case studies on leadership from various regions around the world. This beneficial and practical book has a specific emphasis on academic, clinical and policy leadership and is relevant for all readers. Finally, a section on leadership development focuses on coaching and mentoring, business acumen, collaboration and patient advocacy provides an important contribution. Authors are distinguished APN leaders from around the world along with junior authors who are emerging leaders being mentored by these leaders. This book will appeal to APN clinicians, students and emerging leaders who want to bring important global lessons to their work. The book will become an indispensable part of the libraries of all APN leaders at all stages in their development worldwide.

"We believe the procedures outlined will improve the marketability of the nurse practitioner and serve as a good reference tool for family and/or adult nurse practitioners in an ambulatory care setting. Prerequisites for this book are basic anatomy and physiology, microbiology, pharmacology, principles of aseptic technique, and basic nursing skills. The procedures in this book were chosen based on a comprehensive study of types of procedures currently used in the nurse practitioner's practice. Many of the procedures can be used in any ambulatory setting"-- Provided by publisher.

This is a comprehensive resource that addresses all aspects of palliative care, providing advanced practice content and practical reference for clinical practice across all settings.