Books

Summary: "This brand new book discusses the most relevant technique or combination thereof for each disease and provides guidance on which modality to use -It is a disease oriented reference meant for interpreting integrated imaging studies. While it focuses on PET-CT and SPECT-CT, it also integrates PET-MR were applicable. Features: Allows clinical hybrid imaging users to compare modalities and decide whether to use PET/CT, PET/MR or SPECT/CT to solve a clinical question. Focus on clinical applications sans technological & radiopharmaceutical details. Inclusion of emerging field of PET/MR. New PART III on workflow and normal scans with various clinical tracers. Only book that incorporates PET/MR in a systematic way"--Provided by publisher.

Summary: This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg "Hallmarks of Cancer" are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the books closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease.

Contents:
Preface
Molecular and Cell Biology of Cancer when cells break the rules and hijack their own planet
Cancer as an Evolutionary Process
Cell signaling in cancer
The cell cycle, cytoskeleton and cancer
Genomic Instability: DNA Repair and Cancer
Cell metabolism in cancer
an energetic switch
Cancer immunoediting and hijacking of the immune system
Angiogenesis
vessels recruitment by tumor cells
Tumor niche disruption and metastasis: the role of epithelial-mesenchymal transition (EMT)
Case studies
Molecular Pathology perspective and impact on oncologic patients management
Index.

Contents:
Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here
1. Introduction
2. Preclinical In Vitro and In Vivo Models of Metastasis
2.1. In Vitro Models
2.2. In Vivo Models
3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level)
3.1. Lab Tests/Histopathology
3.2. Noninvasive Blood Tests
3.3. Small Animal Imaging
3.4. Molecular-Genetic Imaging (Promoter-Based Protocols)
3.5. Circulating Tumor Cells
4. Approaches Used to Detect Metastatic Lesions (on a Clinical Level)
4.1. Biomarkers for Metastasis
4.2. Imaging Procedures
4.3. Circulating Tumor Cells
5. Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics)
6. Challenges Faced in Detecting Metastatic Cells
7. Conclusions and Future Directions
Acknowledgments
References
Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment
1. Introduction
2. Models to Study Tumor Cell Dormancy
3. Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy
4. Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment
5. Endosteal and Perivascular Niches Support Cancer Cell Dormancy
6. Reactivation from Dormancy
7. The Immune System and Dormancy
8. Summary and Outlook
References
Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches
1. Introduction
2. Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations
2.1. Epidemiological Analysis
2.2. Genetic Analysis Human Cohorts
3. Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis
3.1. Breast Cancer
3.2. Prostate Cancer
3.3. Melanoma
4. Conclusions
Acknowledgments
References
Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic ...
Concluding Thoughts
Acknowledgments
References
Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy
1. Introduction
2. Key Players
2.1. Monocytes
2.2. Macrophages
2.3. Neutrophils
2.4. T Lymphocytes
2.5. Natural Killer Cells
3. Invasion and Intravasation
3.1. Macrophages
3.2. Neutrophils
3.3. T Lymphocytes
4. Survival and Extravasation
4.1. Monocytes
4.2. Neutrophils
4.3. T Lymphocytes
4.4. NK Cells
5. Ectopic Growth
5.1. Macrophages
5.2. Neutrophils
5.3. T Lymphocytes
5.4. NK Cells
6. Therapeutic Implications
Acknowledgments
References
Chapter Six: MicroRNA and Metastasis
1. MicroRNAs
1.1. Noncoding RNAs and the Discovery of MicroRNAs
1.2. miRNA Biogenesis and Mechanisms of Action
1.3. miRNA Functions
2. miRNAs in Cancer ...

Summary: The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

Contents:
1. Solving the puzzle of neurodegeneration / Michael S. Wolfe
2. Prion diseases / Robert C.C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David A. Harris
3. Alzheimer's Disease: toward a quantitative biological approach in describing its natural history and underlying mechanisms / Colin L. Masters, Ben Gu, Simon Laws, Yen Y Lim, Blaine Roberts, Victor L. Villemagne and Konrad Beyreuther
4. Neurodegeneration and the ordered assembly of tau / Michel Goedert
5. Amyotrophic lateral sclerosis and other TDP-43 proteinopathies / Jorge Gomez-Deza and Christopher E. Shaw
6. Parkinson's disease and other synucleinopathies / Mark R. Cookson
7. Huntington's disease and other polyglutamine repeat diseases: molecular mechanisms and pathogenic pathways / Audrey S. Dickey and Albert R. La Spada
8. Prion-like propagation in neurogenerative diseases / Wouter Peelaerts, Veerle Baekelandt and Patrik Brundin
9. Neurodegenerative diseases as protein folding disorders / Jermey D. Baker, Jack M. Webster, Lindsey B. Shelton, John Koren, III, Vladimir N. Uversky, Laura J. Blair and Chad A. Dickey
10. Heat shock proteins and protein quality control in Alzheimer's disease / Fred W. Van Leeuwen and Harm H. Kampinga
11. Neurodegenerative diseases and autophagy / Angeleen Fleming, Mariella Vicinanza, Maurizio Renna, Claudia Puri, Thomas Ricketts, Jens Füllgrabe, Ana Lopez, Sarah M. De Jager, Avraham Ashkenazi, Mariana Pavel, Floriana Licitra, Andrea Caricasole, Stephen P. Andrews, John Skidmore and David C. Rubinsztein
12. Neurodegenerative Diseases and axonal transport / Lawrence S. Goldstein and Utpal Das
13. Mitochondrial function and neurodegenerative diseases / Heather M. Wilkins, Ian Weidling, Scott Koppel, Xiaowan Wang, Alex Von Schulze and Russell H. Swerdlow
14. Non-cell autonomous degeneration: role of astrocytes in neurodegenerative diseases / Sarah E. Smith and Azad Bonni
15. Neurodegenerative diseases and RNA-mediated toxicity / Tiffany W. Todd and Leonard Petrucelli
16. Neuroinflammation in are-related neurodegenerative diseases / Kathryn P. MacPherson, Maria E. De Sousa Rodrigues, Amarallys F. Cintron and Malú G. Tansey
17. Neurodegenerative diseases and the aging brain / Stephen K. Godin, Jinsoo Seo and Li-Huei Tsai
Index.

Contents:
Intro
Preface
Contents
Contributors
1 An Introduction to Phagocytosis
Introduction to Phagocytosis
The Cell Biology of Phagocytosis
Phagocytosis Dissected
The Importance of Phagocytosis
Evolution and Phagocytosis
Introduction to the Chapters in This Book
2 A Brief History of Phagocytosis
Introduction
Purpose of Chapter
Let's Start at the Very Beginning
The Eureka Moment of Metchnikoff
Inside the Phagocyte
Phagosomal pH
Ca2+ Ions and Phagocytosis
Conclusion
3 The Role of Membrane Surface Charge in Phagocytosis
Introduction Lipids That Contribute to Phagocytosis and Phagosome Maturation
Phospholipid Dynamics and Inner Leaflet Charge During Phagocytosis and Phagosome Maturation
Role of Electrostatic Interactions in Protein Localization During Phagocytosis and Phagosome Maturation
Relevance of Inner Leaflet Surface Charge to Phagocytes and Immunity
Concluding Remarks
4 Receptor Models of Phagocytosis: The Effect of Target Shape
Introduction
Why Modelling?
Receptor Models of Phagocytosis
The Basic Receptor Model
Phagocytosis Versus Other Types of Endocytosis
The Effect of Target Shape Known Experimental Results
Modelling Shape Dependence
Model Extensions and the Future
Summary
5 Decision Making in Phagocytosis
Introduction
Uptake, Processing, and Release of Long Particles
Uptake of a Long Particle
Phagosome Processing
Release of a Particle
Myosin-II Does Not Accumulate on the Incipient Phagosome
Conversion of a Tubular Phagosome into a Bleb
Simultaneous Uptake and Release of Particles
Struggle for a Bacterium
Discussion
6 Membrane Tension and the Role of Ezrin During Phagocytosis
Introduction Apparent Expansion of Cell Surface Area During Phagocytosis
Exocytotic Addition to the Plasma Membrane
Cell Surface "Wrinkles"
Membrane Tension and Cell Shape Changes
Wrinkles and Membrane Tension
Molecular Maintenance of Membrane Tension
Ezrin
Ezrin and Membrane Tension
Ezrin and Phagocytosis
Regulation Membrane Tension by Ezrin During Phagocytosis
Actin Push and the Brownian Ratchet
Conclusion and Synthesis
7 Molecular Mechanisms of Calcium Signaling During Phagocytosis
Abbreviations
Introduction
Overview of Ca2+ Signaling
Phagocytic Ca2+ Signals Ca2+-Permeable Channels Involved in Phagocytic Ca2+ Signals
ORAI Channels, STIM Proteins and Junctate
TRPC Channels
TRPC3
TRPC4/5
TRPC6
TRPM Channels
TRPM2
TRPM8
TRPML Channels
TRPV Channels
TRPV1 and TRPV2
TRPV4
P2X Channels
P2X7
P2X4
Conclusions and Future Directions
8 Calpain Activation by Ca2+ and Its Role in Phagocytosis
Introduction
Ca2+ in Phagocytosis and Cell Shape Change
Calpain Activation in Shape Change
Calpain in Phagocytosis
Structure of Calpain 1 and 2
Physiological Activation of Calpain by Ca2+ in Cells Conclusions

Contents:
1. Molecular and extracellular cues in motor neuron specification and differentiation / R.L. Swetenburg, S.L. Stice and L. Karumbaiah
2. Natural history of amyotrophic lateral sclerosis / M.J. Magnussen and J.D. Glass
3. Genetics of amyotrophic lateral sclerosis / K.P. Kenna, J.E. Landers and N. Ticozzi
4. Molecular mechanisms of amytrophic lateral sclerosis / M. Collins and R. Bowser
5. An introduction to natural history, genetic mapping, and clinical spectrum of spinal muscular atrophy / A. McDonough, L. Urquia and N. Boulis
6. Genetics of spinal muscular atrophy / A.H.M. Burghes and V.L. McGovern
7. Introduction to gene and stem-cell therapy / D.M. O'Connor
8. Gene therapy for amytrophic lateral sclerosis / A. Dosante
9. Stem cell therapy for amytrophic lateral sclerosis / K.S. Chen and E.L. Feldman
10. Gene therapy for spinal muscular atrophy / M.R. Miller, E.Y. Osman and C.L. Lorson
11. Cellular therapy for spinal muscular atrophy / I. Faravelli and S. Corti
12. Clinical trials to date / B.J. Mader and N. Boulis.

Summary: This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.

Summary: This book provides the most up-to-date coverage of the combined use of imaging modalities in order to acquire important functional and morphological information on cardiovascular disease and enhance disease detection. The recent developments in PET/MRI, cardiac CT, PET/CT, and SPECT/CT and their impact on clinical practice are explained, and special attention is also devoted to imaging parameters and protocols for use in practice and research. The utility of multimodality imaging techniques for diagnosis and evaluation is discussed in the context of various clinical scenarios, including ischemic cardiomyopathy, myocarditis, myocardial fibrosis, cardiac sarcoidosis, and atherosclerotic plaque disease. Written by renowned researchers and clinicians, the book is an ideal concise reference on today's most advanced imaging techniques. It will appeal to all clinicians, trainees, and technicians who are involved in the diagnosis and risk assessment of cardiovascular disease.

Contents:
PET/MRI: Physics, Instrumentation, and Scanners
Potential Role of Cardiac PET/MRI in Cardiovascular Disease
Initial Experience
PET/MRI for Cardiac Imaging
Technical Considerations
Role of PET and MRI in Assessing Cardiac Sarcoidosis
Myocardial Viability: Hibernating and Stunning Myocardium
underlying Pathophysiology
Concepts of SPECT, PET and MRI in the assessment of myocardial viability leading to PET/MRI
Adding T-1 Mapping and MRI for Myocardial Fibrosis Assessment
Potential of PET/MRI in Assessment of Cardiovascular Plaque Burden and Activity
CT in Assessing Coronary Morphology, Perfusion and Viability
3D Fusion Display of CT-Coronary Angiography and Scintigraphic Perfusion Imaging
3D Fusion Display of CT-Coronary Angiography and PET-Determined Myocardial Flow Reserve. Is it the Future?
Adding CT-measurements of Coronary Artery Calcification to SPECT Perfusion Imaging for Risk Stratification
Cardiac Risk Stratification in Heart Failure Patients
Combining Assessment of Myocardial Viability with Sympathetic Innervations.

Summary: Throughout history black seeds, Nigella sativa seeds, have been highly revered for its medicinal properties. Thymoquinone (TQ), an active principle component of the volatile oil of black cumin seeds, is an emerging natural compound with a wide range of medical applications, and has several beneficial pharmacological actions i.e anti-oxidant, anti-diabetic, anti-inflammatory, anti-microbial, anti-tumor, anti-mutagenic, anti-epileptic, hepatoprotective, neuroprotective, and nephroprotective. As such, it is important to move TQ from the bench to bedside. This book illustrates the therapeutic importance of TQ, offering a detailed account of some of its molecular and therapeutic properties, and discussing in depth its anti-diabetic, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial, anti-epileptic and hepatoprotective actions. Lastly, the book examines the future prospects of TQ research and its use as a pharmaceutical.

Contents:
Intro; Preface; Contents; Contributors; About the Editor;
1: Introduction; 1.1 History of Using Black Cumin Seeds for Therapeutic Purposes; 1.2 Components of Nigella sativa Seeds; 1.3 Therapeutic Actions of Thymoquinone; References;
2: Antidiabetic Action of Thymoquinone; 2.1 Diabetes and Glycation; 2.2 Antidiabetic Action of N. sativa Seeds; 2.3 Antidiabetic Action of Thymoquinone (TQ); 2.4 Conclusions; References;
3: Anticancer Action of Thymoquinone; 3.1 Introduction; 3.2 Structure and Function of Thymoquinone; 3.3 Possible Mechanism of Action of Thymoquinone. 3.20 Nano-formulation of Thymoquinone and Its Role in Killing Cancel Cells3.21 Conclusion and Future Prospective; References;
4: Antioxidant and Anti-inflammatory Action of Thymoquinone; 4.1 Oxidative Stress and Antioxidants; 4.2 Antioxidant Action of Thymoquinone; 4.3 Anti-inflammatory Action of Thymoquinone; References;
5: Antimicrobial Action of Thymoquinone; 5.1 Introduction; 5.2 Antibacterial Activity; 5.3 Antiviral Activity; 5.4 Antifungal Activity; 5.5 Conclusions; References;
6: Hepatoprotective Action of Thymoquinone; 6.1 Introduction. 3.4 Action of Thymoquinone on Cancer3.5 Thymoquinone Action Against Cancer Through Modulation of Molecular Targets; 3.6 Cell Cycle; 3.7 Enzymes Linked with Cancer Initiation; 3.8 Growth Factors; 3.9 Protein Kinases; 3.10 Antioxidant Enzymes; 3.11 Apoptosis; 3.12 Transcription Factor; 3.13 P53 and PTEN Gene; 3.14 Phase I and Phase II Enzyme; 3.15 Androgen Receptor; 3.16 Telomerase; 3.17 Cellular Components/Microtubules Degradation; 3.18 Human Trial Study Based on Thymoquinone; 3.19 LD 50, Safety and Toxicity Level of Thymoquinone. 6.2 Protective Action of TQ Under In Vitro Conditions6.3 Protection of Isolated Mice/Rat Hepatocytes by TQ; 6.4 Protective Effect of TQ in Mice/Rat Liver Under In Vivo Conditions; 6.5 Conclusions; References;
7: Anti-epileptic Action of Thymoquinone; 7.1 Epilepsy; 7.2 Anti-epileptic Activity of TQ; 7.3 Role of TQ in Temporal Lobe Epilepsy (TLE); 7.4 Beneficial Interaction of TQ with Known Anti-epileptic Drugs; References;
8: Future Prospects and Conclusions; 8.1 Potential Use of Thymoquinone (TQ) in the Inhibition of Important Cell Signaling Pathways; 8.2 Inhibition of Akt Signaling.

Summary: This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader to benefit from their experiences by providing a valuable tool for the implementation of these techniques in daily practice. Though the use of molecular techniques is well established in surgical biopsies, to date they are not widely used in connection with cytological material. However, in some fields like lung cancer or aspirates from the pancreas and biliary tract the only available material for diagnosis is the cytological preparation a fact that has created a need for the standardization of molecular techniques on cytology. .

Contents:
Why Cytology for Molecular Testing? Pros and Cons
How to Prepare Cytological Samples for Molecular Testing
Molecular Tests Use in Cytological Material (analytical phase)
Molecular Cytology Applications on Head and Neck
Molecular Cytology Applications on Lung
Molecular Cytology of Serous Effusions
Molecular Cytology Applications on Urine
Molecular Cytology Applications on Gynecological Cytology
Molecular Applications in Hematolymphoid Cytology
Molecular Cytology Application on Thyroid
Molecular Cytology Applications on Pancreas and Biliary Tract
Molecular Cytology Applications in Soft Tissue (Pediatric tumors)
Molecular Cytology Applications in Metastases
Clinical Integration of Molecular Results on Cytology (post-analytical phase).

Summary: Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy.

Summary: This book discusses molecular approaches in plant as response to environmental factors, such as variations in temperature, water availability, salinity, and metal stress. The book also covers the impact of increasing global population, urbanization, and industrialization on these molecular behaviors. It covers the natural tolerance mechanism which plants adopt to cope with adverse environments, as well as the novel molecular strategies for engineering the plants in human interest. This book will be of interest to researchers working on the impact of the changing environment on plant ecology, issues of crop yield, and nutrient quantity and quality in agricultural crops. The book will be of interest to researchers as well as policy makers in the environmental and agricultural domains.

Contents:
Molecular approaches in plant biology and environmental challenges
Promising transcription factors for salt and drought tolerance in plants
Role of superoxide dismutases (SODs) in stress tolerance in plants
Receptor-like kinases and environmental stress in plants
Role of histone acetyltransferases in plant abiotic stress
Function of plant heat shock transcription factors in abiotic stress
Mode of communication between plants during environmental stress
Molecular approaches for combating multiple abiotic stresses in crops of arid and semi-arid region
Applications of landscape genetics to study the effect of varying landscapes and environmental challenges in plant populations
Arsenic in rice grain : role of transporters in arsenic accumulation
Metabolic engineering of stress protectant secondary metabolites to confer abiotic stress tolerance in plants
An update on the applications of CRISPR/Cas9 technology in tomato
Transgenic approaches for enhancement of salinity stress tolerance in plants
Genome engineering in rice : applications, advancements and future perspectives
Secondary metabolite pathways in medicinal plants : approaches in reconstruction and analysis
Molecular biology of glandular trichomes and their functions in environmental stresses
Gene regulatory networks : current updates and applications in plant biology
Genomics and transcriptomics advance in plant sciences
Molecular interventions to ameliorate environmental stresses in orchids
Development of bryophytes as a new model system to understand the phenomenon of terrestrialization with environmental changes
Role of endosymbionts in nutritional uptake of sap sucking insects.

Summary: Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins, and is both up to date and authoritative.

Contents:
Overview and history of botulinum neurotoxin research and exploitation
Pharmacology of botulinum neurotoxins
Absorption and transport of botulinum neurotoxins
The botulinum neurotoxin complex and the role of ancillary proteins
Neurotoxin structure
The dual receptor recognition of botulinum neurotoxins
Translocation, entry into the cell
Protease activity of the botulinum neurotoxins
Molecular basis for persistence of botulinum neurotoxins
Clostridium botulinum genomes and genetic diversity
Botulinum neurotoxin risks and detection in environment, agriculture and food chains
Botulism as a disease of humans
Prevention and treatment of botulism.

Summary: The book offers an integrated overview of plant-pathogen interactions. It discusses all the steps in the pathway, from the microbe-host-cell interface and the plant's recognition of the microbe to the plant's defense response and biochemical alterations to achieve tolerance / resistance. It also sheds light on the classes of pathogens (bacteria, fungus and viruses); effector molecules, such as PAMPs; receptor molecules like PRRs and NBS-LRR proteins; signaling components like MAPKs; regulatory molecules, such as phytohormones and miRNA; transcription factors, such as WRKY; defense-related proteins such as PR-proteins; and defensive metabolites like secondary metabolites. In addition, it examines the role of post-genomics, high-throughput technology (transcriptomics and proteomics) in studying pathogen outbreaks causing crop losses in a number of plants. Providing a comprehensive picture of plant-pathogen interaction, the updated information included in this book is valuable for all those involved in crop improvement.

Contents:
Intro; Preface; Contents; Contributors; About the Editors; Abbreviations;
1: Arabidopsis thaliana as a Model Organism to Study Plant-Pathogen Interactions; 1.1 Introduction; 1.2 Plant-Pathogen Interactions; 1.3 How Arabidopsis thaliana Recognize and Respond to Pathogens?; 1.4 Arabidopsis thaliana: An Important Model Host for Studying Plant-Pathogen Interactions; 1.5 A. thaliana-Pathogen Interactions; 1.5.1 Arabidopsis-Virus Interactions; 1.5.2 Arabidopsis-Bacterium Interactions; 1.5.3 Arabidopsis-Fungus Interactions; 1.6 Conclusion; Glossary; References. 2.2.4.7 Magnaporthe oryzae2.2.5 Bacterial Biotrophy and Necrotrophy; 2.2.6 Basis of Bacterial Pathogenicity: The HRP System; 2.2.7 Effector Proteins Synthesized by the Bacteria; 2.2.8 Extracellular Polysaccharide and Toxins Produced by Bacteria; 2.2.9 Plant Cell Wall-Degrading Enzymes (PCWDE); 2.3 Plant Defense Responses Against Pathogen Attack; 2.4 Use of Effector Proteins in Plant Breeding; 2.5 Prospects; Glossary; References;
3: Plantâ#x80;#x93;Virus Interactions; 3.1 Introduction; 3.2 Environment and Evolution Modulate Plant Pathogenesis; 3.3 Plantâ#x80;#x93;Virus Relationships.
2: Fungal and Bacterial Biotrophy and Necrotrophy2.1 Introduction; 2.2 Fungal Biotrophy and Necrotrophy; 2.2.1 Effector Proteins Secreted by Fungal Plant Pathogens; 2.2.2 Effectors Produced by Pathogens Disturb the Phytohormonal Signaling; 2.2.3 Phytotoxins Released by Fungal Pathogens; 2.2.4 Significant Effector Proteins Secreted by Few Biotrophic, Hemibiotrophic, and Necrotrophic Fungi; 2.2.4.1 Cladosporium fulvum; 2.2.4.2 Ustilago maydis; 2.2.4.3 Blumeria graminis; 2.2.4.4 Botrytis cinerea; 2.2.4.5 Sclerotinia sclerotiorum; 2.2.4.6 Alternaria brassicicola. 3.3.1 Compatible Hostâ#x80;#x93;Virus Relationships3.3.2 Non-compatible Hostâ#x80;#x93;Virus Relationships; 3.4 Methods of Diagnosis of Viruses; 3.4.1 Serological Assays: Traditional Molecular Method of Disease Detection; 3.4.2 Molecular Techniques or Nucleic Acid-Based Methods for Virus Detection; 3.4.3 Innovative Detection Methods; 3.4.3.1 Lateral Flow Microarrays (LFM); 3.4.3.2 Methods Based on the Analysis of Volatile Compounds as Biomarkers; 3.5 Transmission of Viruses; 3.6 Virus Accumulation and Movement in the Host; 3.6.1 Viral Factors Involved in Plant Pathogenesis. 3.6.2 Viral Long-Distance Movement3.7 Responses of Plants to Viruses; 3.7.1 Cellular Stress; 3.7.2 Development Defects; 3.7.3 Abnormalities in Chloroplast; 3.8 Viral Infection and Physiological Functioning of Host Plants; 3.8.1 Virion Disassembly and Viral Genome Translation; 3.8.1.1 Host Factors in Virion Decoating; 3.8.2 Viral Replication Complex Composition; 3.8.2.1 Host Factors in Viral Genome Translation; 3.8.2.2 Regulation of Viral Replication by Viral Protein Modifications; 3.8.2.3 Interference of Viral and Plant Factors with Hormone Regulation.

Summary: This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions - including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction - that will be of interest to scientists and researchers from various disciplines in the life sciences.

Contents:
Intro; Foreword; Preface; Contents; About the Editors;
1: Aging Principles and Perspectives for Intervention; 1.1 Introduction; 1.2 Basis of Survival: Homeostasis Versus Homeodynamics; 1.3 Genetics and Epigenetics of Aging; 1.4 Molecular Mechanisms of Aging; 1.5 Aging Interventions: Treatment, Prevention or Management; 1.5.1 Piecemeal Remedies; 1.5.2 Replenishment and Supplementation; 1.5.3 Strengthening the Homeodynamics; 1.5.4 Gene Therapy and Intelligent Redesigning; 1.6 Recapitulation; References 2.12 Non-coding RNAs and Amyotrophic Lateral Sclerosis (ALS)2.13 miRNAs and circRNAs as Potential Targets for Neurodegenerative Diseases; 2.14 Progress Being Made; 2.15 Strategies Ahead; 2.16 Advent of Non-coding RNAs as an Early Diagnostic Tool; 2.17 C. elegans as Model Organism to Study the Role of Non-coding RNAs for Neurodegenerative Diseases; 2.18 Future Directions; References;
3: The Potential Role of Stem Cell Reprogramming in Antiaging; 3.1 Stem Cells and Aging; 3.2 Recent Advances in Cellular Reprogramming Era; 3.3 Molecular Mechanism of Stem Cell Reprogramming
2: Non-coding RNAs as Potential Targets for Treatment and Early Diagnosis of Age-Associated Neurodegenerative Diseases2.1 Introduction; 2.2 Neurodegenerative Diseases; 2.2.1 Alzheimer's Disease; 2.2.2 Parkinson's Disease; 2.3 Challenges in Treating the Neurodegenerative Diseases; 2.4 Treatments Available; 2.5 Junk DNA Hypothesis; 2.6 Non-coding RNAs; 2.7 History of miRNA; 2.8 Role of Non-coding RNAs in Various Disease Progressions; 2.9 Non-coding RNAs and Alzheimer's Disease; 2.10 Non-coding RNAs and Parkinson's Disease; 2.11 Non-coding RNAs and Huntington's Disease 3.4 Antiaging Strategy with In Vivo and In Vitro Stem Cell Reprogramming3.5 Therapeutic Approaches of Aging; 3.6 Conclusion; References;
4: Tissue Engineering and Regenerative Medicine: A Translational Research for Antiaging Strategy; 4.1 Introduction; 4.2 Stem Cells, Sources, and Its Therapeutic Potential; 4.3 Tissue Engineering for Aging-Associated Disorder; 4.4 Biomaterials; 4.5 Tissue Engineering Strategies for Aging-Associated Liver Disorders; 4.6 Tissue Engineering Strategies for Aging-Associated Cardiovascular Disorders

Summary: This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. Aimed at oncologists, researchers, and all medical professionals who work with cancer.

Contents:
Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
Essential Concepts and Techniques in Molecular Biology
Cancer Genomics
Cancer Cytogenetics
The Epigenetic Basis of Human Cancer
Cancer Proteomics
An Overview of Cancer Genes
Oncogenes and the Initiation and Maintenance of Tumorigenesis
Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors
Senescence, Apoptosis, and Cancer
Novel Cancer Therapies Targeting Angiogenesis
Beyond the Primary Tumor: Progression, Invasion, and Metastasis
Simple Sequence Mutations
Single Nucleotide Polymorphisms and Cancer Susceptibility
Chromosomes and Chromosomal Instability in Human Cancer
Epigenetic Mechanisms in Cancer Development
MicroRNAs and Cancer
Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas
Viral Mechanisms in Human Carcinogenesis
Hormonal Carcinogenesis: The Role of Estrogens
Sporadic Cancers
Hereditary Cancer
Retinoblastoma: Clinical and Molecular Perspectives
Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light
Hereditary Colorectal Cancer
Hereditary Breast and Ovarian Cancer
The Molecular Basis of Prostate Carcinogenesis
Molecular Basis of Lung Carcinogenesis
The Molecular Basis of Skin Carcinogenesis
The Molecular Biology of Leukemias
Molecular Mechanisms in Non-Hodgkin Lymphoma
The Molecular Pathology of Head and Neck Squamous Cell Carcinoma
Ovarian Cancer
Molecular Pathology of Bone and Soft Tissue Tumors
The Molecular Biology of Human Brain Tumors
Cancer Drug Discovery and Anticancer Drug Development
Biological Principles and Clinical Application of EGFR Inhibitors in Cancer
Targeting Oncoproteins for Molecular Cancer Therapy
Therapeutic Agents that Inhibit Angiogenesis
Small Molecule Inhibitors
Molecular Detection and Diagnosis of Cancer
Gene Therapy in the Treatment of Human Cancer
Personalized Medicine for the Treatment of Human Cancer.

Summary: This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in "nonlinear anomalies." An example includes medical countermeasures for Ebola and Marburg viruses under the "Animal Rule." Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question "what informs molecular mechanisms of resilience?" that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.

Contents:
Prologue
Preface
Social Entropy
Virus among Us
Non-linear Anomalies
Bacterial Infectious Disease
Cure 2000
Chemicals in the Environment
Immune Defense
Metabolic Defense
Analog Genetics
Eteplirsen
Regulating Resilience.

Summary: "Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves"--Publisher's description.

Contents:
Unit 1: Basic chemical and biological principles. Cells and organisms
Basic genetics
DNA, RNA, and protein
Genes, genomes, and DNA
Manipulation of nucleic acids
Unit 2: The genome. The polymerase chain reaction
Cloning genes for analysis
DNA sequencing
Genomics and systems biology
New chapter to cover metagenomics, symbiosis, epigenomics etc
Unit 3: The central dogma of molecular biology. Cell division and DNA replication
Transcription of genes
Protein synthesis
Protein structure and function
Proteomics: global analysis of proteins
Unit 4: Regulating gene expression. Regulation of transcription in prokaryotes
Regulation of transcription in eukaryotes
Processing of RNA
Regulation at the RNA level
Genome defense (RNAi and CRISPR)
Analysis of gene expression (transcriptome)
Unit 5: Subcellular life forms. Plasmids
Viruses
Mobile DNA
Unit 6: Changing the DNA blueprint. Mutations and repair
Recombination
Bacterial genetics
Molecular evolution.

Contents:

v. 1. Nature and metabolism of extracellular proteins.

Summary: This book examines key issues in lncRNA biology, including critical studies that have led to the discovery and annotation of lncRNAs in numerous species and the molecular mechanisms for a few lncRNA that have begun to emerge.

Contents:
Preface
Chromatin regulation by long non-coding RNAs
Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs
Roles of long non-coding RNAs in X-chromosome inactivation
Roles of Long Non-Coding RNAs in Genomic Imprinting
Dysregulation of long noncoding RNAs in human disease
Functions of long non-coding RNAs in non-mammalian systems
Emerging technologies to study long non-coding RNAs
Long non coding RNAs and nuclear body formation and function
The role of long non-coding RNAs in immunity
Novel methods to study long non-coding RNAs
OMICs of long non-coding RNAs
Cancer epigenetics and long non-coding RNAs
Roles of long non-coding RNAs in human development
Index.

Summary: This book provides an essential update on the startling array of novel insecticidal toxins and drugs produced by the fascinating bacterium Photorhabdus. The respective chapters describe everything from the detailed molecular biology of the 'Toxin complexes' or Tc's to the complexity of insect immune response in relation to both the bacterium and its nematode vector. The volume covers both primary (toxin production and regulation) and secondary (natural product synthesis and regulation) metabolism and emphasises the potential use of toxins and drugs in both agriculture and medicine. It also discusses in detail two totally novel quorum sensing mechanisms and the likely role of LuxR solos in sensing the presence of different bacterial hosts. Lastly, the book explores the unique case of P. asymbiotica, which seems to have evolved the ability to infect both insects and humans. This synthesis proves that Photorhabdus truly does offer a 'gold mine' for the discovery of novel insecticidal proteins and novel natural products with potential uses in agriculture and medicine alike.

Contents:
Insecticidal Toxin Complexes from Photorhabdus luminescens
Identifying Anti-host Effectors in Photorhabdus
Flagellar Regulation and Virulence in the Entomopathogenic Bacteria
Xenorhabdus nematophila and Photorhabdus luminescens
Natural Products from Photorhabdus and Other Entomopathogenic Bacteria
The Regulation of Secondary Metabolism in Photorhabdus
Quorum Sensing and LuxR Solos in Photorhabdus
Insect Immunity to Entomopathogenic Nematodes and Their Mutualistic Bacteria
Photorhabdus asymbiotica as an Insect and Human Pathogen
A Review of Clinical Cases of Infection with Photorhabdus Asymbiotica
A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus

Summary: "As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know," introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens."-- Provided by publisher.

Contents:
Cells and genomes
Cell chemistry and bioenergetics
Proteins
DNA, chromosomes, and genomes
DNA replication, repair, and recombination
How cells read the genome: from DNA to protein
Control of gene expression
Analyzing cells, molecules, and systems
Visualizing cells
Membrane structure
Membrane transport of small molecules and the electrical properties of membranes
Intracellular compartments and protein sorting
Intracellular membrane traffic
Energy conversion: mitochondria and chloroplasts
Cell signaling
The cytoskeleton
The cell cycle
Cell death
Cell junctions and the extracellular matrix
Cancer
Development of multicellular organisms
Stem cells and tissue renewal
Pathogens and infection
The innate and adaptive immune systems.

Contents:
Part I. Introduction to the Cell
Chapter 1. Cells, genomes, and the diversity of life
Chapter 2. Cell chemistry and bioenergetics
Chapter 3. Proteins
Part II. Basic Genetic Mechanisms
Chapter 4. DNA, chromosomes, and genomes
Chapter 5. DNA replication, repair, and recombination
Chapter 6. How cells read the genome : From DNA to protein
Chapter 7. Control of gene expression
Part III. Ways of Working with Cells
Chapter 8. Analyzing cells, molecules, and systems
Chapter 9. Visualizing cells and their molecules
Part IV. Internal Organization of the Cell
Chapter 10. Membrane structure
Chapter 11. Small-molecule transport and electrical properties of membranes
Chapter 12. Intracellular organization and protein sorting
Chapter 13. Intracellular membrane traffic
Chapter 14. Energy conversion and metabolic compartmentation : Mitochondria and chloroplasts
Chapter 15. Cell signaling
Chapter 16. The cytoskeleton
Chapter 17. The cell cycle
Chapter 18. Cell death
Part V. Cells in Their Social Context
Chapter 19. Cell junctions and the extracellular matrix
Chapter 20. Cancer
Chapter 21. Development of multicellular organisms
Chapter 22. Stem cells in tissue homeostasis and regeneration
Chapter 23. Pathogens and infection
Chapter 24. The innate and adaptive immune systems
Glossary
Index.

Summary: This book presents the cellular details and the basic molecular biology approaches for understanding cardiac valvular disease. It provides novel cellular targets for developing future clinical trials and comprehensive clinical discussion of this expanding field. Molecular Biology of Valvular Heart Disease will guide physicians on the potential medical therapies to treat valvular heart disease while providing a platform for cellular targeting of valvular heart disease. Residents and fellows in cardiology, interventional cardiology, cardiac surgery, and current and future valve biologists alike will find this book to be an invaluable resource for developing further interest and understanding of the cellular basis for cardiac valvular disease treatment.

Contents:
Part I. Manipulation of DNA
Getting oriented: practicing with micropipettes
Purification and digestion of plasmid (vector) DNA
Completion of vector preparation and polymerase chain reaction amplification of egfp
Preparation on insert DNA (egfp) PCR product
DNA ligation and transformation of Escherichia coli
Part II. Screening transformants
Screening of transformants, part I
Screening of transformants, part II
Analysis of DNA sequence from a positive clone
Part III. Expression, detection, and purification of recombinant proteins from bacteria
Expressions of fusion protein from positive clones, SDS-PAGE and Western Blot: Part I
Expressions of fusion protein from positive clones, SDS-PAGE and Western Blot: Part II
Extraction of recombinant protein from Escherichia coli using a glutathione affinity culture
Analysis of purification fractions
Part IV. Analysis of mRNA levels
Total RNA purification
Analysis of gst:egfp mRNA levels by RT-qPCR: Part I
Analysis of gst:egfp mRNA levels by RT-qPCR: Part II
Analysis of gst:egfp mRNA levels by semiquantitative RT-PCR, Part I
Analysis of gst:egfp mRNA levels by semiquantitative RT-PCR, Part II
Part V. Modulation of gene expression
Culturing mammalian cells
Transient transfection of mammalian cells
RNAi-mediated knockdown of EGFP, Part I
RNAi-mediated knockdown of EGFP, Part II
RNAi-mediated knockdown of EGFP, Part III
CRISPR-mediated knockout of EGFP, Part I
CRISPR-mediated knockout of EGFP, Part II
Advanced CRISPR, Part I
Advanced CRISPR, Part II
Interim laboratory session
Advanced CRISPR, Part III
Advanced CRISPR, Part IV
Advanced CRISPR, Part V
Advanced CRISPR, Part VI.

Contents:
1. Introduction
2. Advantage of molecular testing using cytologic materials
3. Validation of molecular techniques in liquid-based specimens
4. Establishment of molecular cytology laboratory
5. Researches on molecular cytopathology
6. Molecular Biomarkers in cervical cytology
7. Molecular Biomarkers in thyroid cytology
8. Molecular Biomarkers in head and neck cytology
9. Molecular Biomarkers in pulmonary cytology
10. Molecular Biomarkers in breast cytology
11. Molecular Biomarkers in urine cytology
12. Molecular Biomarkers in hepatobiliary and pancreatic cytology
13. Molecular Biomarkers in mesothelioma and body fluid cytology
14. Molecular Biomarkers in soft tissue cytology
15. Molecular Biomarkers in brain tumors
16. Molecular cytopathology in therapeutic surveillance.

Contents:
Introduction to R statistical environment
Simple sequence analysis
Annotating gene groups
Next-generation sequencing : introduction and genomic applications
Quantitative transcriptomics : qRT-PCR
Advanced transcriptomics : gene expression microarrays
Next-generation sequencing in transcriptomics : RNA-seq experiments
Deciphering the regulome : from CHIP to CHIP-seq
Inferring regulatory and other networks from gene expression data
Analysis of biological networks
Proteomics : mass spectrometry
Measuring protein abundance with ELISA
Flow cytometry : counting and sorting stained cells.

Summary: Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor β (TGFβ); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive β-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.

Summary: Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer.^However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome.^The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

Contents:
1 Cancer Stem Cells in gynecologic cancer
2 Patient-derived xenograft models in gynaecological malignancies
3 Cancer genomic profiling of gynecological malignancies by Todai OncoPanel, a twin DNA and RNA panel
4 Investigating the molecular carcinogenesis of ovarian high-grade serous cancer
5 The role of G protein-coupled receptor signaling in gynecologic malignancy
6 Tailor-made therapy according genetic alteration in epithelial ovarian cancers
7 Signaling and drug resistance
8 Molecular analysis in endometrial carcinoma
9 Molecular Landscape in Ovarian Clear Cell Carcinoma
10 Molecular pathology and clinicopathological significance of endometrial carcinoma
11 Novel approach for therapeutics of cervical cancer based on HPV-associated carcinogenesis at the cervix
12 Hereditary gynecological malignancy and molecular features.

Summary: Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.

Contents:
Clinical FISH Testing for the Diagnosis of Solid Tumors
Epidermal Growth Factor Receptor Testing in Lung Adenocarcinoma
The Human Epidermal Growth Factor Receptor 2 (HER2)
Tamoxifen and Irinotecan Pharmacogenomics
Hepatitis C Virus Testing
Laboratory Testing for HIV Infection: Advances after 27 years
Detection of Herpes Simplex Virus in Cerebrospinal Fluid using Real-time PCR
Toward a Safer Blood Supply: The Impact of Molecular Testing
Chromosomal Microarrays
BRCA1 and BRCA2 Testing in Inherited Breast Cancer
Cystic Fibrosis: Carrier Testing, Newborn Screening, and Diagnostic Testing
Newborn Screening by Tandem Mass Spectrometry and Molecular Confirmation
Next Generation Clinical Diagnostics: The Sequence of Events.

Contents:
Nucleic acids and proteins
Gene expression and epigenetics
Nucleic acid extraction methods
Resolution and detection of nucleic acids
Analysis and characterization of nucleic acids and proteins
Nucleic acid amplification
Chromosomal structure and chromosomal mutations
Gene mutations
DNA sequencing
DNA polymorphisms and human identification
Detection and identification of microorganisms
Molecular detection of inherited diseases
Molecular oncology
DNA-based tissue typing
Quality assurance and quality control in the molecular laboratory.

Summary: The books Molecular Diagnostics Part 1 and 2 provide a comprehensive and practical overview of the state-of-the-art molecular biological diagnostic strategies that are being used in a wide variety of disciplines. The editors and experts in their respective fields have combined their knowledge to write these two books. Many years of experience in the development, application and quality control of molecular diagnostic methods is reflected herewith. Molecular Diagnostics Part 1 is dedicated to the theoretical backgrounds of the technologies often applied in molecular diagnostics, in which nucleic acid amplification methods (such as real-time PCR), sequencing and bioinformatics are the basic tools. The assay design and -development, combined with items of trouble-shooting are described in detail. As a foundation of reliable molecular diagnostic assays, the quality control required for validation, implementation and performance of molecular diagnostic assays is thoroughly discussed. This book also provides extensive information for those working with molecular techniques in a wide variety of research applications using conventional and real-time PCR technology, Sanger and high throughput sequencing techniques, and bioinformatics. Molecular Diagnostics Part 2 highlights the applications of the molecular diagnostic methods in the various diagnostic laboratories, comprising: - Clinical microbiology - Clinical chemistry - Clinical genetics - Clinical pathology - Molecular hematopathology - Veterinary health - Plant health - Food safety Both full-color and well-illustrated books are particularly valuable for students, clinicians, scientists and other professionals who are interested in (designing) molecular diagnostic methods and for those who wish to broaden their knowledge on the current molecular biological revolution. The information in the books highlights the trend of the integration of multiple (clinical) disciplines into one universal molecular laboratory.

Contents:
The importance of nucleic acids in diagnostics
Background and analysis of nucleic acids
Primers and probes
Basic principles of nucleic acid hybridisation
Principles of PCR
Quality assurance, management and control in molecular diagnostics
Quantitative isothermal molecular amplification techniques
DNA sequencing
Bioinformatics
The ongoing revolution of MALDI TOF Mass Spectrometry for Molecular Diagnostics
Information in the amplification curve.

Summary: "This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers -- clinicians, pathologists, laboratorians, and other inquisitive minds -- independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing "excise and pray" approaches with personalized medicine."--Publisher's website.

Contents:
1. Introduction
2. Basics of Nucleic Acids and Molecular Biology
3. Molecular Methods
4. Melanoma. Part I. Risk Assessment, Diagnosis, and Prognosis: Using Molecular Tools to Diagnose Melanoma, Predict Its Behavior, and Evaluate for Inheritable Forms
5. Melanoma. Part II. Personalized Medicine: Using Molecular Tools to Guide Targeted Therapy
6. Leukemia and Lymphoma. Part I. Mycosis Fungoides and Sézary Syndrome: Using Molecular Tools to Aid in the Diagnosis, Staging, and Therapy for Mycosis Fungoides and Sézary Syndrome
7. Leukemia and Lymphoma. Part II: Primary Cutaneous B-Cell Lymphoma and Other Non-MF/SS HematopoieticTumors
8. Tumors of the Soft Tissue: Using Molecular Tools to Aid in the Diagnosis of Soft Tissue Tumors and the Management of the Sarcoma Patient
9. Genodermatoses. Part I: Muir-Torre Syndrome
10. Genodermatoses. Part II: Other Hereditary Dermatologic Disease
11. Infectious Disease Testing
12. Emerging Molecular Applications and Summary.

Contents:
Novel insights/translational implication from the emerging biology of melanoma / Antoni Ribas
Emerging clinical issues in melanoma in the molecularly targeted era / Ryan J. Sullivan and Michael B. Atkins
Integrating molecular biomarkers into current clinical management in melanoma / Ragini Kudchadkar, Geoffrey Gibney, and Vernon K. Sondak
Advances in adjuvant therapy : potential for prognostic and predictive biomarkers / Diwakar Davar [and three others]
Immunologic monitoring of cancer vaccine trials using the ELISPOT assay / Lisa H. Butterfield and Mary Jo Buffo
Markers for anti-cytotoxic T-lymphocyte antigen 4 (CTLA- 4) therapy in melanoma / Michael A. Postow [and four others]
Marker utility for combination therapy / Ester Simeone, Antonio M. Grimaldi, and Paolo A. Ascierto
Assaying for BRAF V600E in tissue and blood in melanoma / David J. Panka, James W. Mier, and Ryan J. Sullivan
Selecting patients for KIT inhibition in melanoma / Richard D. Carvajal, Omid Hamid, and Cristina R. Antonescu
Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma / Roger S. Lo and Hubing Shi
Current status of diagnostic and prognostic markers in melanoma / Danielle Levine and David E. Fisher
Chromosomal copy number analysis in melanoma diagnostics / Jeffrey P. North, Swapna S. Vemula, and Boris C. Bastian
Construction and analysis of multiparameter prognostic models for melanoma outcome / Bonnie E. Gould Rothberg and David L. Rimm
Immunohistochemical diagnostic and prognostic markers for melanoma / Mehdi Nosrati and Mohammed Kashani-Sabet
Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma / Xiaowei Xu [and four others]
Tumor-infiltrating lymphocytes and their significance in melanoma prognosis / Tobias Schatton [and three others]
Pathological staging of melanoma / David E. Elder
Genotyping of human leukocyte antigen (HLA) ancestral haplotypes as prognostic marker in cancer using PCR analysis / Lisa Villabona [and three others]
B7-H abnormalities in melanoma and clinical relevance / Barbara Seliger
Melanoma susceptibility genes and risk assessment / Alexander Marzuka-Alcalá, Michele Jacobs Gabree, and Hensin Tsao
Clinical, pathologic, and imaging features and biological markers of uveal melanoma / Alia B. Rashid and Hans E. Grossniklaus
Prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile / J. William Harbour
Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma / Arupa Ganguly, Jennifer Richards-Yutz, and Kathryn G. Ewens
ERBB4 mutation analysis : emerging molecular target for melanoma treatment / Christopher Lau [and three others]
Epigenetic markers of prognosis in melanoma / Luca Sigalotti [and four others]
Isolation of melanoma cell subpopulations using negative selection / Ana Slipicevic [and three others]
Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients / Eiji Kiyohara [and three others]
Detection of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma / Yangyang Wang [and three others]
Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma / Brian A. Boone and Michael T. Lotze
The clinical use of PET/CT in the evaluation of melanoma / Khun Visith Keu and Andrei H. Iagaru
Immune system functional pathway analysis using single cell network profiling (SCNP) : a novel tool in cancer immunotherapy / Alessandra Cesano and David Spellmeyer
Quantitative and spatial image analysis of tumor and draining lymph nodes using immunohistochemistry and high-resolution multispectral imaging to prdict metastasis / Kim R.M. Blenman and Peter P. Lee
COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing / Elena Castellanos-Rizaldos [and seven others]
Isolation of circulating microRNAs from microvesicles found in human plasma / John F. Quackenbush [and seven others]
Detection of circulating tumor cells by photoacoustic flowmetry / Ryan M. Weight and John A. Viator
Statistical design and evaluation of biomarker studies / Kevin K. Dobbin
Tissue resources for clinical use and marker studies in melanoma / Jonathan L. Curry [and five others].

Summary: This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Contents:
Introduction of molecular diagnostics
Molecular Diagnostics in Bladder cancer
Molecular Diagnostics in Lung cancer
Molecular Diagnostics in Brain cancer
Molecular Diagnostics in Melanoma
Molecular Diagnostics in Breast cancer
Molecular Diagnostics in Non-Hodgkin lymphoma
Molecular Diagnostics in Cervical cancer
Molecular Diagnostics in Colorectal cancer
Molecular Diagnostics in Pancreatic cancer
Molecular Diagnostics in Oral cancer
Molecular Diagnostics in Prostate cancer
Molecular Diagnostics in Kidney cancer
Molecular Diagnostics in Skin cancer
Molecular Diagnostics in Leukaemia
Molecular Diagnostics in Thyroid cancer
Molecular Diagnostics in Liver cancer
Molecular Diagnostics in Uterine cancer
Molecular Diagnostics in Ovarian cancer
Pharmacogenomics Testing for Medication & Drug Response.

Summary: Although all living beings modify their environment, human beings have acquired the ability to do so on a superlative space-time scale. As a result of industrialization and the use of new technologies, the anthropogenic impact has been increasing in the last centuries, causing reductions in the sizes or the extinction of numerous wild populations. In this sense, from the field of conservation genetics, various efforts have been made in recent decades to provide new knowledge that contributes to the conservation of populations, species, and habitats. In this book, we summarize the concrete contributions of researchers to the conservation of the Neotropical mammals using Molecular Ecology techniques. The book is divided into three major sections. The first section provides an up-to-date review of the conservation status of Neotropical mammals, the applications of the molecular markers in its conservation, and the use of non-invasive and forensic genetic techniques. The second and third sections present, respectively, a series of case studies in various species or taxonomic groups of Neotropical mammals.

Contents:
Chapter 1 - Introduction
Section 1 - Background and Technical Notes
Chapter 2 - Conservation status of Neotropical mammals: A review
Chapter 3 - The use of molecular markers in Neotropical mammal conservation
Chapter 4 - Non-invasive genetic sampling techniques applied to conservation genetic studies in mammals
Chapter 5 - Landscape Genomics in wildlife conservation
Chapter 6 - The use of forensic DNA on the conservation of Neotropical mammals
Chapter 7 - Leveraging conservation through massive sequencing technologies
Chapter 8 - The importance of considering genetic factors in population viability analysis
Section 2 - Case studies
Chapter 9 - Effects of the sample sizes in the determination of the true number of haplogroups within a species with conservation purposes: the case of the Cebus albifrons in Ecuador, and the cases of the jaguarundi, the kinkajou and the coati throughout Latin America
Chapter 10 - Molecular Ecology Approaches to Study Neotropical Bats
Chapter 11 - Phylogeographic approximation of the subspecies Odocoileus virginianus veraecrusis (Goldman & Kellogg 1940) in the South Eastern Coastal Plain, Mexico.-Chapter 12 - Perspectives on Neotropical primate conservation genetics
Chapter 13 - The use of Genetic Footprints as a tool to trace the origin of the heavily trafficked White-footed tamarins (Saguinus leucopus) in Colombia
Chapter 14 - Schrödinger's cat in genetics for the conservation of species in the tropical Andes: bibliographical review of the order Carnivora
Chapter 15 - Conservation genetics of rodents in Argentina
Chapter 16 - Conservation genetics of caviomorphs and sigmodontine rodents in the Neotropics.-Chapter 17 - Aquatic Mammals of the Amazon: a review of gene diversity, population structure and phylogeography
Conclusion
Chapter 18 - Concluding remarks.

Summary: Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.

Contents:
Section I. Neuroinformatics, Computational Models and Data Analysis
Section II. Searching for New Genes: Natural Genetic Variation
Section III. Discovery of New Genes and New Functions of Genes Using Gene Expression Analyses
Section IV. Discovery of Genes and Biological Mechanisms: Forward Genetics and Other Screening-Based Methods
Section V. Manipulating Known Genes to Understand Biological Function: Reverse Genetics
Section VI. Ethical Considerations.

Summary: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.

Contents:
Early eye development: Specification and Determination
Generation of third dimension: Axial patterning in the developing Drosophila eye
Catching the Next Wave: Patterning of the Drosophila eye by the Morphogenetic Furrow
Ghost in the Machine- the Peripodail Epithelium
Cell Polarity in Drosophila Retina
Negative regulation for neural patterning in the Drosophila eye
Adhesion and the cytoskeleton in the Drosophila pupaleye
Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways
Drosophila cancer modeling using the eye imaginal discs
Recent contributions of the Drosophila eye to unraveling the basis of neurodegeneration
Genetic regulation of early eye development in non-dipteran insects
Eyes for an eye: A comparative account on compound eye of Drosophila melanogaster with vertebrate eye
Index.

Summary: "This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma"--Publisher's description.

Contents:
Introduction. Epidemiology of endometrial carcinoma: etiologic importance of hormonal and metabolic influences / Ashley S. Felix, Hannah P. Yang, Daphne W. Bell [and others]
Clinical behavior and treatment of endometrial cancer / Divya Gupta
Pathology of endometrial carcinoma / Sigurd F. Lax
Molecular profiling. Traditional approaches to molecular genetic analysis / Christopher J. Walker, Paul J. Goodfellow
Next-generation sequencing / Matthieu Le Gallo, Fred Lozy, Daphne W. Bell
Endometrial carcinoma: specific targeted pathways / Nuria Eritja, Andree Yeramian, Bo-Juen Chen, David Llobet-Navas [and others]
Mouse models. LKB1 as a tumor suppressor in uterine cancer: mouse models and translational studies / Christopher G. Peña, Diego H. Castrillón
Mig-6 mouse model of endometrial cancer / Tae Hoon Kim, Jung-Yoon Yoo, Jae-Wook Jeong
PI3K/PTEN/AKT genetic mouse models of endometrial carcinoma / Ayesha Joshi, Lora Hedrick Ellenson.

Summary: Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

Contents:
Part I: The Foundation of IBD Genetics, Human and Animal Studies. A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges / Xinjun Cindy Zhu and Richard P. MacDermott
Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies / Jonas Halfvarson
Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease / Emiko Mizoguchi, Atsushi Mizoguchi and Atul K. Bhan
Part II: The Genetic and Molecular Makeup of Inflammatory Bowel Disease. Complex Disease Genes and Their Discovery / Jeffrey C. Barrett and Mark J. Daly
The Genetics of Crohn's Disease / Andre Franke and Miles Parkes
Genetics of Ulcerative Colitis / Mauro D'Amato, Catherine Labbé and John D. Rioux
Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases / Charlie W. Lees and Alexandra Zhernakova
Molecular Profiling of IBD Subtypes/Response to Therapy / Isabelle Cleynen and Séverine Vermeire
Epigenetics of Inflammatory Bowel Disease / Robert Häsler, Stefan Schreiber and Stephan Beck
Part III: Pathogenetic Pathways in Inflammatory Bowel Disease. Nod1 and Nod2 and the Immune Response to Bacteria / Maria Kaparakis-Liaskos, Dana J. Philpott
The IL23-Th17 Axis in Intestinal Inflammation / Kevin J. Maloy
Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics / Natalia B. Nedelsky, Petric Kuballa and Adam B. Castoreno
The Epithelial Barrier / Stefan Koch, Asma Nusrat and Charles A. Parkos
Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" / Nouara Lhocine and Philippe J. Sansonetti
Cytokines in Inflammatory Bowel Disease / Matthias A. Engel and Markus F. Neurath
Part IV: Concluding Remarks and Future Perspectives. Towards Personalized Therapy in Inflammatory Bowel Disease / Dermot P.B. McGovern.

Summary: Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn's disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

Contents:
Part 1: The Foundation of IBD Genetics, Human and Animal Studies
A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges
Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies
Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease
Part 2: The Genetic and Molecular Makeup of Inflammatory Bowel Disease
Complex Disease Genes and their Discovery
The Genetics of Crohn's Disease
Genetics of Ulcerative Colitis
Genetic Overlap between Inflammatory Bowel Disease and Other Diseases
Molecular Profiling of IBD Subtypes/Response to Therapy
Epigenetics of Inflammatory Bowel Disease
Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease
Nod1 and Nod2 and the Immune Response to Bacteria
The IL-23-Th17 Axis in Intestinal Inflammation
Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics
The Epithelial Barrier
Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli"
Cytokines in Inflammatory Bowel Disease
Part 4: Concluding Remarks and Future Perspectives
Towards Personalized Therapy in Inflammatory Bowel Disease
Index.

Summary: A comprehensive collection of perspectives by experts in mycobacterial molecular biology, written by leading experts in the field. This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

Summary: This book provides a comprehensive overview of the importance of molecular imaging in multiple myeloma, with detailed explanation of its clinical impact. Other important features are the definition of criteria that will aid PET/CT interpretation; identification and explanation of the most frequent pitfalls; a brief overview of the advantages and limitations of DWI MR imaging, still an experimental technique in multiple myeloma; and examination of the possible role of emerging PET tracers. When appropriate, clinical cases are used to illustrate key teaching points. All physicians involved in oncological imaging should regularly reassess and update their routine practice in the evaluation of multiple myeloma patients. This is especially true now, given the recent clarification by the International Myeloma Working Group (IMWG) of the criteria for bone damage requiring therapy and the emerging data supporting the role of the newer functional imaging techniques in predicting outcome and/or evaluating response to therapy. In this challenging context, Molecular Imaging in Multiple Myeloma will be of high value for nuclear medicine physicians, radiologists, and hematologists.

Contents:
1.Multiple Myeloma: clinical aspects
2. What does a clinician need from new imaging procedures?
3.FDG PET in Multiple Myeloma
4. Role of Standard Magnetic Resonance Imaging
5.Whole Body Diffusion-Weighted Magnetic Resonance Imaging: A new era for whole body imaging in myeloma?
6.CXCR4 imaging in Multiple Myeloma
7.PET/CT with Standard NON-FDG Tracers
8. The issue of interpretation
9. Clinical Teachning Cases: FDG PET/CT .

Summary: The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications in the era of evidence-based medicine.

Contents:
Computed tomography and magnetic resonance imaging
Single photon emission computed tomography
tracer
Non-peptidyl 18F-labelled PET tracers as radioindicators for the noninvasive detection of cancer
Ultrasound Imaging
Optical and opto-acoustic imaging
Multifunctional magnetic imaging probes
Modern X-ray concepts-differential phase-contrast imaging
Pre-clinical SPECT and SPECT-CT
Optical and photo-acoustic imaging
Applications of small animal PET
Preclinical molecular imaging using PET and MRI
Molecular ultrasound imaging
Advanced microscopy techniques
Mass spectroscopy
Quantitative SPECT-CT
Optical imaging of breast tumors and of gastrointestinal cancer by laser-induced fluorescence
FDG PET and PET-CT
Non-FDG PET-CT
Clinical MR biomarkers
Clinical PET-MR
Advanced ultrasound imaging
Radiomics and Radiogenomics
Cross validation techniques
Image-guided brain surgery
Image-guided abdominal surgery
Photon radiation therapy
Particle radiation therapy
Internal radiotherapy
Future challenges of multimodality imaging.

Contents:
Chapter 1. Molecular imaging
Chapter 2. Basic cell & molecular biology
Chapter 3. Ovreview of imaging modalities
Chapter. 4. Molecular imaging strategies
Chapter 5. Assays
Chapter 6. Nanoparticle imaging
Chapter 7. Clinical applications
Chapter 8. Molecular imaging examples
Chapter 10. Frequently asked questions
Chapter 11. Useful tables
Chapter 12. Probe structures table.

Summary: Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.

Contents:
From Amoeba to Macrophages: Exploring the Molecular Mechanisms of Legionella pneumophila Infection in Both Hosts / Pedro Escoll and Monica Rolando
The Legionella pneumophila Two-Component Regulatory Systems that Participate in the Regulation of Icm/Dot Effectors / Gil Segal
Facets of Small RNA-Mediated Regulation in Legionella pneumophila / Hana Trigui, Nilmini Mendis and Laam Li
Type II Secretion and Legionella Virulence / Nicholas P. Cianciotto
Effector Translocation by the Legionella Dot/Icm Type IV Secretion System / Jiazhang Qiu and Zhao-Qing Luo
Modulation of Small GTPases by Legionella / Roger S. Goody and Aymelt Itzen
Host Lipidation: A Mechanism for Spatial Regulation of Legionella Effectors / Stanimir S. Ivanov and Craig Roy
Phosphoinositide Lipids and the Legionella Pathogen Vacuole / Ina Haneburger and Hubert Hilbi
Legionella Phospholipases Implicated in Virulence / Katja Kuhle and Antje Flieger
Cytotoxic Glucosyltransferases of Legionella pneumophila / Yury Belyi, Thomas Jank and Klaus Aktories
Modulation of the Ubiquitination Machinery by Legionella / Andree Hubber, Tomoko Kubori and Hiroki Nagai
Host Signal Transduction and Protein Kinases Implicated in Legionella Infection / Andrew D. Hempstead and Ralph R. Isberg
Mouse Models of Legionnaires' Disease / Andrew S. Brown and Ian R. van Driel.

Contents:
Part 1. Introduction
1. History of Research on Pathogenesis of Idiopathic Nephrotic Syndrome
Part 2. Minimal-change nephrotic syndrome (MCNS)
2. Hemopexin in Minimal Change Nephrotic Syndrome
3. Angiopoietin-like-4 (Angptl4) in MCNS
4. Co-stimulatory molecule CD80 (B7.1) in MCNS
5. Energy and Mammalian target of rapamycin complex 1 (mTORC1) in minimal change nephrotic syndrome
6. The role of c-mip in the pathogenesis of Minimal Change Nephrotic Syndrome
7. REGULATORY T-CELLS AND OXIDATIVE STRESS IN MINIMAL CHANGE NEPHROPATHY
8. CYTOKINES AS ACTIVE FACTORS IN MINIMAL CHANGE NEPHROTIC SYNDROME
Part 3. Focal segmental glomerulosclerosis (FSGS)
9. Soluble urokinase-type plasminogen activator receptor (suPAR) in Focal Segmental Glomerulosclerosis
10. CYTOKINES AS ACTIVE FACTORS IN FOCAL SEGMENTAL GLOMERULOSCLEROSIS
Part 4. Idiopathic Membranous Nephropathy (IMN)
11. M-Type Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) in Membranous Nephropathy
12. Cationic Bovine Serum Albumin as Cause of Membranous Nephropathy: From Mice to Men
Part 5. Treatment in Idiopathic Nephrotic Syndrome
13. Podocytes as a direct target of drugs used in Idiopathic Nephrotic Syndrome.

Summary: This book presents a novel molecular description for understanding the regulatory mechanisms behind the autonomy and self-organization in biological systems. Chapters focus on defining and explaining the regulatory molecular mechanisms behind different aspects of autonomy and self-organization in the sense of autonomous coding, data processing, structure (mass) formation and energy production in a biological system. Subsequent chapters discuss the cross-talk among mechanisms of energy, and mass and information, transformation in biological systems. Other chapters focus on applications regarding therapeutic approaches in regenerative medicine. Molecular Mechanisms of Autonomy in Biological Systems is an indispensable resource for scientists and researchers in regenerative medicine, stem cell biology, molecular biology, tissue engineering, developmental biology, biochemistry, biophysics, bioinformatics, as well as big data sciences, complexity and soft computing.

Contents:
Intro; Dedication; Preface; Contents;
Chapter 1: The Relativity ofCode, Energy, andMass Versus theRelativity ofEnergy andMass; 1.1 Introduction; 1.2 Biological Systems Are Highly Autonomous; 1.3 Significance andFundamental Applications ofRegulatory Mechanisms ofAutonomy inBiological Systems; 1.4 Chemical Foundation ofLife; 1.5 Physical Foundation ofLife: Thermodynamics andGeneral Relativity ofEnergy andMass; 1.6 Code: TheThird Dimension ofNature's Law; 1.7 Relativity ofCode, Energy, andMass: TheMolecular Mechanism ofAutonomy inBiological Systems; References 2.3 Cognitive Chemistry Algorithm: ABiomimetic Multilayer Molecular Coding Algorithm forSolving NP ProblemsReferences;
Chapter 3: Molecular Mechanism ofSelf-Organization inBiological Systems; 3.1 An Introduction toSelf-Organization andEmbryonic Organogenesis; 3.2 Potential Applications ofSelf-Organization inTechnology andBiomedical Sciences; 3.3 Remarkable Properties ofSelf-Organization; 3.3.1 Polarity Formation; 3.3.2 Energy Balance; 3.4 Self-Organization Is aBottom-Up Process; 3.5 Developmental Biology ofEmbryonic Organogenesis 3.5.1 Developmental Biology ofAutonomous Morphogenesis andSpontaneous Pattern Formation3.5.2 Developmental Biology ofAutonomous Specification andDifferentiation; 3.5.3 Molecular andPhysical Foundation ofEmbryonic Self-Organization byCognitive Chemistry andRelativity ofCode Energy andMass; References;
Chapter 4: Molecular Mechanism ofSelf-Fueling inBiological Systems by Relativity ofCode, Energy, andMass; 4.1 Self-Fueling Property ofLiving Systems andtheMaintenance ofCell Organization; 4.2 Photosynthesis: ANatural Sustainable Energy Solution forLife 4.3 Quantum Coherence: TheEfficiency ofSolar Energy Uptake andConversion inPhotosynthesis4.4 Photosynthesis: Quantum Coherence, Energy Transfer, andProduction ofDesigner Mass; 4.5 Photosynthesis: APromising Model Illustrating theRelativity ofCode, Energy, andMass intheNature; 4.6 Photosynthesis Is aCode-Based Energy andMass Transformation System; 4.7 Inspiring fromPhotosynthesis andConstruction ofaCycle ofMolecular Code, Energy, andMass forSustainability; References
Chapter 2: Molecular Mechanism ofCoding andAutonomous Decision-Making inBiological Systems2.1 Molecular Mechanism ofAutonomous Coding andData Processing Based onPhysical andChemical Foundation ofLife; 2.2 Basic Principles ofCoding andData Processing inBiological Systems; 2.2.1 Information Storage inMolecules andMaterials; 2.2.2 Multilayer Coding; 2.2.3 Molecular Coding and Algorithmic Chemistry; 2.2.4 Inherent andConserved Coding; 2.2.5 Conditional Coding; 2.2.6 Dynamic andDe Novo Coding; 2.2.7 Integration ofSoftware andHardware

Contents:
Early Development of the Gonads
Origin and Differentiation of the Somatic Cells of the Genital Ridges
The formation and migration of primordial germ cells in mouse and man
The Gonadal Supporting Cell Lineage and Mammalian Sex Determination: the Differentiation of Sertoli and Granulosa Cells
Mesonephric cell migration into the gonads and vascularization are processes crucial for testis development
Origin and Differentiation of Androgen-producing Cells in the Gonads
Germ cell commitment to oogenic versus spermatogenic pathway
the role of retinoic acid
Ovarian Folliculogenesis
Control of oocyte growth and development by intercellular communication within the follicular niche
Biology of the Sertoli cell in the Fetal, Pubertal and Adult Mammalian Testis
Mechanisms Regulating Spermatogonial Differentiation
Stem cells in mammalian gonads
A Role of microRNAs in Cell Differentiation during Gonad Development
The Battle of the Sexes: Human Sex Development and its Disorders
Methods for the study of gonadal development.

Summary: This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the worlds population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Contents:
Inflammation, immunity and vaccine development for the gastric pathogen Helicobacter pylori
Impact of Helicobacter pylori Virulence Factors on the Host immune Response and Gastric Pathology
Genetic polymorphisms in inflammatory and other regulators in gastric cancer: risks and clinical consequences
MALT lymphoma as a model of chronic inflammation-induced gastric tumor development
Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis
Importance of toll-like receptors in pro-inflammatory and anti-inflammatory responses by Helicobacter pylori infection
Role of NOD1 and ALPK1/TIFA signalling in innate immunity against Helicobacter pylori infection
Carbohydrate-dependent and antimicrobial peptide defense mechanisms against Helicobacter pylori infections
The sweeping role of cholesterol depletion in the persistence of Helicobacter pylori infections
Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion
Mechanisms of inflammasome signaling, microRNA induction and resolution of inflammation by Helicobacter pylori
Impact of the gastrointestinal microbiome in health and disease: co-evolution with the host immune system
Resolution of gastric cancer-promoting inflammation: a novel strategy for anti-cancer therapy.

Summary: This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the worlds population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Contents:
Inflammation, immunity and vaccine development for the gastric pathogen Helicobacter pylori
Impact of Helicobacter pylori Virulence Factors on the Host immune Response and Gastric Pathology
Genetic polymorphisms in inflammatory and other regulators in gastric cancer: risks and clinical consequences
MALT lymphoma as a model of chronic inflammation-induced gastric tumor development
Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis
Importance of toll-like receptors in pro-inflammatory and anti-inflammatory responses by Helicobacter pylori infection
Role of NOD1 and ALPK1/TIFA signalling in innate immunity against Helicobacter pylori infection
Carbohydrate-dependent and antimicrobial peptide defense mechanisms against Helicobacter pylori infections
The sweeping role of cholesterol depletion in the persistence of Helicobacter pylori infections
Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion
Mechanisms of inflammasome signaling, microRNA induction and resolution of inflammation by Helicobacter pylori
Impact of the gastrointestinal microbiome in health and disease: co-evolution with the host immune system
Resolution of gastric cancer-promoting inflammation: a novel strategy for anti-cancer therapy.

Summary: This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments"--Publisher's description.

Contents:
Introduction to molecular mechanisms in notch signal transduction and disease pathogenesis / Benedetto Daniele Giaimo, Tilman Borggrefe
Molecular mechanisms of receptor/ligand interactions. Structural insights into notch receptor-ligand interactions / Penny A. Handford, Boguslawa Korona, Richard Suckling, Christina Redfield, Susan M. Lea
The molecular mechanism of notch activation / Klaus N. Lovendahl, Stephen C. Blacklow, Wendy R. Gordon
Regulation of notch function by O-glycosylation / Beth M. Harvey, Robert S. Haltiwanger
Modeling the notch response / Udi Binshtok, David Sprinzak
Endocytic trafficking of the notch receptor / Bj̲örn Schnute, Tobias Troost, Thomas Klein
Intracellular signaling mechanisms. The notch interactome: complexity in signaling circuitry / Diana M. Ho, K. G. Guruharsha, Spyros Artavanis-Tsakonas
Integration of drosophila and human genetics to understand notch signaling related diseases / Jose L. Salazar, Shinya Yamamoto
Mechanisms of non-canonical signaling in health and disease: diversity to take therapy up a notch? / Victor Alfred, Thomas Vaccari
The notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms / Diana Bellavia, Saula Checquolo, Rocco Palermo, Isabella Screpanti
Notch and neurogenesis / Anna Engler, Runrui Zhang, Verdon Taylor
Notch and stem cells / Anna Bigas, Cristina Porcheri
Oscillatory control of notch signaling in development / Ryoichiro Kageyama, Hiromi Shimojo, Akihiro Isomura
CSL-associated corepressor and coactivator complexes / Franz Oswald, Rhett A. Kovall
Disease links and therapeutics. Notch and senescence / Matthew Hoare, Masashi Narita
Control of blood vessel formation by notch signaling / Fabian Tetzlaff, Andreas Fischer
Notch and T cell function: a complex tale / Jyothi Vijayaraghavan, Barbara A. Osborne
Notch in leukemia / Anna C. McCarter, Qing Wang, Mark Chiang.

Summary: This book discusses the pathology of the retina, and reviews current research on the use of cell replacement therapy and short peptides to restore functional activity in retinal neurons. As the book describes, pathologies of the retina, including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, present a long-standing challenge in the practice of clinical ophthalmology. Modern treatment for these conditions, which lead to irreversible blindness, includes laser exposure, surgical intervention, and drugs. These treatments aim to reduce the risk of new complications in the eye; pathogenetic therapy of degenerative diseases of the retina is practically absent in current ophthalmic practice. The first section of the book reviews the molecular mechanisms of age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, and reports on methods of treatment. The second section presents the results of recent experimental studies of the effects of short peptides on pluripotent embryonic cells; on proliferative activity in retinal cells and pigment epithelium; on expression of markers of differentiation or retinal neurons and pigment epithelium; and on the course of hereditary retinal pigmentation in Campbell rats. The third section offers results of clinical studies on the effectiveness of short peptides in patients with macular degeneration, and in patients with retinitis pigmentosa. The author concludes that the regular use of peptides in the treatment of degenerative diseases of the retina can slow the progression of the pathological process and preserve the patient's vision for some 10-15 years. In addition, in 80 percent of patients, it is possible to increase visual function by increasing visual acuity, improving the boundaries of the visual field and the fundus.

Contents:
Chapter 1. Literature review
Chapter 2. Results of experimental studies of short peptides (cytogens) in ophthalmology
Chapter 3. Results of the clinical study of short peptides (cytogens) in ophthalmology
Conclusion.

Summary: Presents the latest molecular diagnostic techniques to support clinical care and basic and clinical research. The authors-all experienced researchers and diagnosticians-have conducted a comprehensive review and evaluation of this rapidly evolving field and written a book that offers a broad range of practical guidance and techniques. Encapsulates the current state of the science and points to new avenues for research that will broaden the application and usefulness of molecular diagnostics.

Contents:
Chapter 28 : Diagnostic Approaches to Genitourinary Tract Infections / Claire C. Bristow, Jeffrey D. Klausner
Chapter 29 : Syndromic Diagnostic Approaches to Bone and Joint infections / Alexander J. McAdam
Virology
Chapter 30 : Molecular Detection and Characterization of Human Immunodeficiency Virus Type 1 / Angela M. Caliendo, Colleen S. Kraft
Chapter 31 : Molecular Detection and Characterization of Hepatitis C Virus / Michael S. Forman, Alexandra Valsamakis
Chapter 32 : Molecular Detection and Characterization of Hepatitis B Virus / Jeffrey J. Germer, Joseph D.C. Yao
Chapter 33 : Molecular Detection of Human Papillomaviruses / Denise I. Quigley, Elizabeth R. Unger
Chapter 34 : Molecular Diagnostics for Viral Infections in Transplant Recipients / Matthew J. Binnicker, Raymund R. Razonable
Fungi and Protozoa
Chapter 35 : Molecular Detection and Identification of Fungal Pathogens / Katrien Lagrou, Johan Maertens, Marie Pierre Hayette
Chapter 36 : Molecular Approaches for Diagnosis of Chagas' Disease and Genotyping of Trypanosoma cruzi / Patricio Diosque, Nicolas Tomasini, Michel Tibayrenc
Chapter 37 : Molecular Approaches for Diagnosis of Malaria and the Characterization of Genetic Markers for Drug Resistance / Lisa C. Ranford-Cartwright, Laura Ciuffreda
Chapter 38 : Molecular Detection of Gastrointestinal Parasites / Jaco J. Verweij, Alex Van Belkum, C. Rune Stensvold
Point-of-Care/Near-Care Diagnostics
Chapter 39 : Molecular Diagnostics and the Changing Face of Point-of-Care / David L. Dolinger, Anne M. Whalen
Chapter 40 : Point-of-Care Technologies for the Diagnosis of Active Tuberculosis / Grant Theron
Chapter 41 : Molecular Diagnostics for Use in HIV/AIDS Care and Treatment in Resource-Limited Settings / Maurine M. Murtagh
Chapter 42 : Rapid Point-of-Care Diagnosis of Malaria and Dengue Infection / Lieselotte Cnops, Marjan Van Esbroeck, Jan Jacobs
The Host and Host Response
Chapter 43 : Implications of Pharmacogenetics for Antimicrobial Prescribing / Ar Kar Aung, Elizabeth J. Phillips, Todd Hulgan, David W. Haas
Chapter 44 : Exploiting MicroRNA (miRNA) Profiles for Diagnostics / Abhijeet Bakre, Ralph A. Tripp
Chapter 45 : Host Response in HIV Infection / Paul J. McLaren, Amalio Telenti
Chapter 46 : Biomarkers of Gastrointestinal Host Responses to Microbial Infections / Rana E. El Feghaly, Hansraj Bangar, David B. Haslam
Information Technology
Chapter 47 : Point-of-Care Medical Device Connectivity: Developing World Landscape / Jeff Baker
Chapter 48 : WHONET: Software for Surveillance of Infecting Microbes and Their Resistance to Antimicrobial Agents / John Stelling, Thomas F. O'brien
Chapter 49 : Cloud-Based Surveillance, Connectivity, and Distribution of the GeneXpert Analyzers for Diagnosis of Tuberculosis (TB) and Multiple-Drug-Resistant TB in South Africa / Wendy S. Stevens, Brad Cunningham, Naseem Cassim, Natasha Gous, Lesley E. Scott
Quality Assurance
Chapter 50 : Molecular Method Verification / Donna M. Wolk, Elizabeth M. Marlowe
Chapter 51 : Molecular Microbiology Test Quality Assurance and Monitoring / Matthew J. Bankowski
Chapter 52 : Proficiency Testing and External Quality Assessment for Molecular Microbiology / Roberta M. Madej
Chapter 53 : Practices of Sequencing Quality Assurance / Kara L. Norman, David M. Dinauer
Chapter 54 : Verification and Validation of Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry-Based Protocols / Matthew L. Faron, Blake W. Buchan, Nathan A. Ledeboer
The Business of Diagnostics
Chapter 55 : Improved Diagnostics in Microbiology: Developing a Business Case for Hospital Administration / Elizabeth M. Marlowe, Susan M. Novak-Weekley, Mark Larocco
Chapter 56 : Molecular Diagnostics and the Changing Legal Landscape / Mark L. Hayman, Jing Wang, Jeffrey M. Libby
Index.

Contents:
Molecular dynamics simulations / Erik R. Lindahl
Monte Carlo simulations / David J. Earl and Michael W. Deem
Hybrid quantum and classical methods for computing kinetic isotope effects of chemical reactions in solutions and in enzymes / Jiali Gao ... [et al.]
Comparison of protein force fields for molecular dynamics simulations / Olgun Guvench and Alexander D. MacKerell, Jr.
Normal modes and essential dynamics / Steven Hayward and Bert L. de Groot
Calculation of absolute protein-ligand binding constants with the molecular dynamics free energy perturbation method / Hyung-June Woo
Free energy calculations applied to membrane proteins / Christophe Chipot
Molecular dynamics simulations of membrane proteins / Philip C. Biggin and Peter J. Bond
Membrane-associated proteins and peptides / Marc F. Lensink
Implicit membrane models for membrane protein simulation / Michael Feig
Comparative modeling of proteins / Gerald H. Lushington
Transmembrane protein models based on high-throughput molecular dynamics simulations with experimental constratints / Andrew J. Beevers and Andreas Kukol
Nuclear magnetic resonance-based modeling and refinement of protein three-dimensional structures and their complexes / Gloria Fuentes, Aalt D.J. van Dijk, and Alexandre M.J.J. Bonvin
Conformational changes in protein function / Haiguang Liu ... [et al.]
Protein folding and unfolding by all-atom molecular dynamics simulations / Hongxin Lei and Yong Duan
Modeling of protein misfolding in disease / Edyta B. Małolepsza
Identifying putative drug targets and potential drug leads : starting points for virtual screening and docking / David S. Wishart
Receptor flexibility for large-scale in silico ligand screens : chances and challenges / B. Fischer, H. Merlitz, and W. Wenzel
Molecular docking / Garrett M. Morris and Marguerita Lim-Wilby.

Summary: "Discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification"-- Provided by publisher.

Summary: Reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others.

Contents:
Basic principles of neuropharmacology
Cellular basis of communication
Synaptic transmission
Signal transduction in the brain
Excitatory and inhibitory amino acids
Widely projecting systems: monoamines, acetylcholine, and orexin
Neuropeptides
Atypical neurotransmitters
Autonomic nervous system
Neural and neuroendocrine control of the internal milieu
Pain
Neuroinflammation
Sleep and arousal
Higher cognitive function and behavioral control
Mood and emotion
Reinforcement and addictive disorders
Schizophrenia and bipolar disorder
Neurodegeneration
Seizure disorders
Stroke and migraine.

Summary: "The book's structure permits the incorporation of a great deal of clinical information, much of it representing the integration of modern molecular genetics and brain imaging with neuropharmacology"-- Provided by publisher.

Contents:
Basic Principles of Neuropharmacology
Cellular Basis of Communication
Synaptic Transmission
Signal Transduction in the Brain
Excitatory and Inhibitory Amino Acids
Widely Projecting Systems : Monoamines, Acetylcholine, and Orexin
Neuropeptides
Atypical Neurotransmitters
Autonomic Nervous System
Neural and Neuroendocrine Control of the Internal Milieu
Pain
Neuroinflammation
Sleep and Arousal
Higher Cognitive Function and Behavioral Control
Mood and Emotion
Reinforcement and Addiction
Schizophrenia and Bipolar Disorder
Neurodegeneration
Seizure Disorders
Stroke and Migraine.

Summary: "The genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target"-- Provided by publisher. "This book was conceived more than five years before its publication date. It was intended to provide a resource that summarized technology, biochemistry, molecular pathophysiology, and targeted therapeutics. As contributors were being recruited and chapters written the field that was being described changed at an accelerating pace. It is a tribute to scientific progress that volumes like this one are out-of-date as they are published, but books like this are not meant to contain the most current laboratory discovery or report the most recent FDA approval"-- Provided by publisher.

Contents:
Part 1.1. Analytical techniques: analysis of DNA
Part 1.2. Analytical techniques: analysis of RNA
Part 2.1. Molecular pathways underlying carcinogenesis: signal transduction
Part 2.2. Molecular pathways underlying carcinogenesis: apoptosis
Part 2.3. Molecular pathways underlying carcinogenesis: nuclear receptors
Part 2.4. Molecular pathways underlying carcinogenesis: DNA repair
Part 2.5. Molecular pathways underlying carcinogenesis: cell cycle
Part 2.6. Molecular pathways underlying carcinogenesis: other pathways
Part 3.1. Molecular pathology: carcinomas
Part 3.2. Molecular pathology: cancers of the nervous system
Part 3.3. Molecular pathology: cancers of the skin
Part 3.14 Molecular pathology: endocrine cancers
Part 3.5. Molecular pathology: adult sarcomas
Part 3.6. Molecular pathology:lymphoma and leukemia
Part 3.7. Molecular pathology: pediatric solid tumors
Part 4. Pharmacologic targeting of oncogenic pathways.

Contents:
Part I. Overview of Basic Cellular Biology
1. Normal molecular biology and definition of terms
2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins
3. Standard nomenclature
introduction and brief overview
Part II. Molecular Oncology Methodology
4. General principles of Oncology testing
5. Molecular methodologies
6. General principles of validating a molecular test
Part III. Molecular testing in Solid Tumors
7. Lung and mediastinum
8. Breast
9. Head and neck (salivary glands)
10. Thyroid and parathyroid (endocrine)
11. Gastrointestinal and Pancreatobiliary
12. Soft tissue
13. Genitourinary system
14. Central Nervous System
15. Skin and adnexa
16. Common Hereditary Cancer Syndromes
Part IV. The future is here
17. Application of next generation sequencing
Part V. Quality Assurance and Regulatory affairs
18. Quality Assurance
pre-analytic, analytic and post-analytic
19. Regulatory affairs (including accreditation)
20. Coding and re-imbursement.

Contents:
1. Identification and biology of CML stem cells
2. Molecular mechanisms of CML stem cell maintenance
3. Roles for signaling molecules in the growth and survival of CML cells
4. Goals of CML treatment in the tyrosine kinase inhibitor era
5. Biomarkers for determining the prognosis of CML
6. Updated European LeukemiaNet recommendations for the management of CML
7. Optimal monitoring of CML treatment: molecular and mutation analysis
8. Recommendations for the management of CML in the era of second-generation TKIs
9. The role of new TKIs and combinations with interferon-α for the treatment of CML
10. Safety profiles of first-line TKIs and managing adverse effects
11. Molecular mechanism of TKI resistance and potential approaches to overcome resistance
12. Discontinuation of therapy and treatment-free remission in CML.

Summary: Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.

Contents:
Preface
Molecular Pathology and Diagnostics of Gliomas.-Molecular Pathology and Diagnostics of Thyroid and Parathyroid Malignancies
Molecular Pathology and Diagnostics of Breast Cancer
Molecular Pathology and Diagnostics of Non-Small Cell Lung Carcinoma
Molecular Pathology and Diagnostics of Colorectal Cancer
Molecular Pathology and Diagnostics in Esophago-Gastric Cancer
Molecular-Genetic Testing in Hepatocellular Carcinoma and Its Premalignant Conditions
Molecular Diagnostics of Pancreatic Cancer
Molecular Pathology and Diagnostics of Prostate Cancer
Molecular Diagnosis of Bladder and Kidney Cancer
Molecular-Genetic Testing in Penile, Scrotal, and Testicular Cancer
Molecular Pathology and Diagnostics of Gynecologic Malignancies
Molecular Pathology of Bone and Soft Tissue Neoplasms and Potential Targets for Novel Therapy
Molecular Pathology and Diagnostics of Pancreatic Endocrine Neoplasms
Molecular Pathology and Diagnostics of Childhood Tumors
Molecular Pathology and Diagnostics of Cutaneous Malignancy
Molecular Diagnostics of Lymphoid Neoplasms
Molecular Diagnostics of Myeloid Neoplasms.

Summary: Molecular Pathology and the Dynamics of Disease bridges the basic science of, and primary clinical literature on, human disease. Topics covered include several major disease areas, such as inflammation and host response, vascular disease, obesity, weight regulation and appetite, cancer biology, drug development, and gene- and cell-based therapeutics that are all presented in a way that emphasizes the interplay between clinical care and investigation. As new technologies and techniques are constantly changing and laboratory scientists plays a critical role in validating data used by clinicians in diagnosing patients, this book provides a timely guide that includes a clinical, research and theory perspective.

Contents:
1. Molecular pathology introduction and research review
2. Challenges in molecular pathology
3. Review of clinical human medical genetics
4. Molecular medicine in action
5. Mechanisms of disease
Index.

Contents:
I. Genetics
II. Inherited Cancers
III. Solid Tumors
IV. Neoplastic Hematopathology
V. Infectious Diseases
VI. Identity Testing
VII. HLA Typing
VIII. Evolving Clinical Molecular Technologies
IX. Laboratory Management.-Index.

Summary: This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.

Contents:
1. Hereditary Predisposition to Primary CNS Tumors
2. Brain Tumor Stem Cells
3. Molecular Pathology Techniques.- 4. Low-grade Gliomas.- 5. Ependymoma.- 6. Adult High Grade (Diffuse) Glioma.- 7. High-Grade Gliomas and DIPG (Pediatric)
8. Oligodendroglial Tumors: Current Treatments and the Promise of Molecular Genetics.- 9. Molecular Pathology of Nervous System Tumors: Medulloblastoma and CNS Primitive Neuroectodermal Tumors.- 10. Subependymal Giant Cell Astrocytoma.- 11. Germ Cell Tumors.- 12. Choroid Plexus Tumors.- 13. Atypical Teratoid Rhabdoid Tumors.- 14. Hemangioblastoma.- 15. Schwannomas.- 16. Molecular Pathology of Nervous System Tumors.- 17. Molecular Genetic Pathology of Meningiomas. .

Summary: This book discusses the application of molecular biology in resource science and authentication of traditional Chinese medicine (TCM). It also reviews the latest developments in pharmacognosy, introduces new perspectives and insights, discusses the hotspots and focuses in the field of molecular pharmacognosy, and predicts new directions of study. In the last five years, the technologies and scope of molecular pharmacognosy have constantly expanded and evolved. As such, this new edition includes extra content, such as the molecular phylogeography of medicinal plants, functional genome of medicinal plants, and synthetic biology of active compounds. Elucidating the concept, theory, and methodology of molecular pharmacognosy, it promotes the full use of the newly developed technologies and methodologies within the framework of molecular pharmacognosy to solve problems in the field.

Contents:
Emerging Molecular Pharmacognosy
Molecular Identification of Traditional Medicinal Materials
Molecular phylogeography of Medicinal plants
The Mechanism of Formation of Dao-di herbs
Seeking for New members of Origin Materials for CMM
Salvation of Rare and Endangered Medicinal Plants
Functional Genome of medicinal plants
Gene Modification of Pharmic Plant Germplasm Resources
Regulation of the Active Constituents Production of medicinal Plants
Synthetic biology of active compounds.

Contents:
Plant Taxonomy: An Historical Perspective, Current Challenges and Perspectives
Guidelines for the Choice of Sequences for Molecular Plant Taxonomy
Leaf Tissue Sampling and DNA Extraction Protocols
DNA Extraction from Herbarium Specimens
Analysis of Variation in Chloroplast DNA Sequences
Mitochondrial Genome and Plant Taxonomy
Nuclear Ribosomal RNA Genes: ITS Region
New Technologies for Ultra-High Throughput Genotyping in Plant Taxonomy
Development of Microsatellite Enriched Libraries
Randomly Amplified Polymorphic DNA (RAPD) and Derived Techniques
Multilocus Profiling with AFLP, ISSR and SAMPL
Transposon Based Tagging: IRAP, REMAP and iPBS
Phylogenetic Reconstruction Methods: An Overview
The Application of Flow Cytometry for Estimating Genome Size and Ploidy Level in Plants
Molecular Cytogenetics (FISH and Flurochrome Banding): Resolving Species Relationships and Genome Organisation
GISH: Resolving Interspecific and Intergeneric Hybrids
On the Relevance of Molecular Tools for the Taxonomy Revision in Malvales, Malvaceae s.l. and Dombeyoideae
What Has Molecular Systematics Contributed to Our Knowledge of the Plant Family Proteaceae.

Contents:
Molecular Radiobiology: Hypoxia
Molecular Targeting of Growth Factor Receptor Signaling
Molecular Targeting of Cell Adhesion Molecules
Tumor Pathophysiology
DNA Repair
Cancer Stem Cells
Normal Tissue. Biomarkers/Personalized Radiation Oncology: EGFR and other RTKs
HPV
Hypoxia
Study design for Biomarker research in radiation oncology
Gene expression/system biology. Molecular Imaging in Radiation Oncology:FMISO as a biomarker for clinical radiation oncology
FDG and beyond
Molecular imaging techniques beyond PET.

Summary: Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Contents:
Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges
Translating Targeted Radiosensitizers into the Clinic
Cartography of the Radiogenome of Human Cancers
Mechanisms and Markers of Clinical Radioresistance
Preclinical Strategies for Testing of Targeted Radiosensitizers
3D Radiation Biology for Identifying Radiosensitizers
Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments
Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers
Targeting the DNA Damage Response for Radiosensitization
Targeting Tumor Metabolism to Overcome Radioresistance.-Targeting Tumor Hypoxia
Normalizing the Tumor Microenvironment for Radiosensitization
Radiosensitizers in the Era of Immuno-Oncology
Index.

Summary: This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

Summary: Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers. Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.

Summary: This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.

Contents:
Intro; Preface; Contents;
Chapter 1: Molecular Basis for Oxidative Stress Induced by Environmental Toxicants in Nematodes; 1.1 Introduction; 1.2 Evidence for the Direct Association of Oxidative Stress with Toxicity of Environmental Toxicants; 1.2.1 Induction of Oxidative Stress in Targeted Organs of Environmental Toxicants; 1.2.2 Pharmacological Evidence for the Association of Oxidative Stress and Toxicity Formation of Environmental Toxicants; 1.2.3 Association of Induction of Oxidative Stress in Intestine and Toxicity Formation in Other Targeted Organs 1.3 Molecular Machinery for the Activation of Oxidative Stress in Nematodes1.3.1 Role of GAS-1 in the Activation of Oxidative Stress; 1.3.2 Role of MEV-1 in the Activation of Oxidative Stress; 1.3.3 Role of ISP-1 in the Activation of Oxidative Stress; 1.3.4 Role of CLK-1 in the Activation of Oxidative Stress; 1.3.4.1 Mitochondrial CLK-1; 1.3.4.2 Nuclear CLK-1; 1.4 Response Signals with the Functions to Defend Against the Oxidative Stress; 1.4.1 Superoxide Dismutases (SODs); 1.4.1.1 SOD-1; 1.4.1.2 SOD-2 and SOD-3; 1.4.1.3 SOD-4; 1.4.1.4 SOD-5; 1.4.2 Catalases (CATs); 1.4.3 Insulin Signaling 1.6 Molecular Basis for Induction of Oxidative Stress in Nematodes Exposed to Environmental Toxicants1.6.1 Alteration in Primary Molecular Mechanism for the Control of Oxidative Stress Induced by Environmental Toxicants; 1.6.2 Induction of Expression for Proteins with the Functions to Defend Against the Oxidative Stress Induced by Environmental Toxicants; 1.6.3 Suppression in Expressions of Genes Mediating the Protection Response Defending Against Oxidative Stress in Nematodes After Chronic Exposure to Certain Environmental Toxicants

Contents:
Array-Based Immunoassays with Rolling-Circle Amplification Detection
Analysis of Protein Changes Using Two-Dimensional Difference Gel Electrophoresis
Assessment of Pathological and Physiological Changes in Mouse Lung Through Bronchoalveolar Lavage
Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex System
Detection of DNA Methylation by MeDIP and MBDCap Assays: An Overview of Techniques
Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR)
Strategies for Measurement of Biotransformation Enzyme Gene Expression
Genotyping Technologies: Application to Biotransformation Enzyme Genetic Polymorphism Screening
TaqMan Fluorogenic Detection System to Analyze Gene Transcription in Autopsy Material
32P-Postlabeling Analysis of DNA Adducts
Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot
DNA Isolation and Sample Preparation for Quantification of Adduct Levels by Accelerator Mass Spectrometry
Analysis of DNA Strand Cleavage at Abasic Sites
Premature Chromosome Condensation in Human Resting Peripheral Blood Lymphocytes Without Mitogen Stimulation for Chromosome Aberration Analysis Using Specific Whole Chromosome DNA Hybridization Probes
Mutagen Sensitivity as Measured by Induced Chromatid Breakage as a Marker of Cancer Risk
Pulsed-Field Gel Electrophoresis Analysis of Multicellular DNA Double-Strand Break Damage and Repair
Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
The Blood-Based Glycophorin A (GPA) Human In Vivo Somatic Mutation Assay
Flow Cytometric Quantification of Mutant T Cells with Altered Expression of the T-Cell Receptor: Detecting Somatic Mutants in Humans and Mice
Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes. (Continued)
Quantifying In Vivo Somatic Mutations Using Transgenic Mouse Model Systems
The Human T-Cell Cloning Assay: Identifying Genotypes Susceptible to Drug Toxicity and Somatic Mutation
Molecular Analysis of Mutations in the Human HPRT Gene
Simultaneous Quantification of t(14; 18) and HPRT Exon 2/3 Deletions in Human Lymphocytes
Mutation Screening of the TP53 Gene by Temporal Temperature Gel Electrophoresis (TTGE)
Detection of Point Mutations of K-ras Oncogene and p53 Tumor-Suppressor Gene in Sputum Samples
ACB-PCR Quantification of Somatic Oncomutation
Gel-Based Nonradioactive Single-Strand Conformational Polymorphism and Mutation Detection: Limitations and Solutions
Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions
Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells
The Sister Chromatid Exchange (SCE) Assay
The Gene Cluster Instability (GCI) Assay for Recombination
Measuring Recombination Proficiency in Mouse Embryonic Stem Cells
Microsatellite Instability: An Indirect Assay to Detect Defects in the Cellular Mismatch Repair Machinery
Unscheduled DNA Synthesis: The Clinical and Functional Assay for Global Genomic DNA Nucleotide Excision Repair
Analysis of Actively Transcribed DNA Repair Using a Transfection-Based System
An Immunoassay for Measuring Repair of UV Photoproducts
Analysis of Double-Strand Break Repair by Nonhomologous DNA End Joining in Cell-Free Extracts from Mammalian Cells
Bioenergetic Analysis of Intact Mammalian Cells Using the Seahorse XF24 Extracellular Flux Analyzer and a Luciferase ATP Assay
Quantification of Selective Phosphatidylserine Oxidation During Apoptosis
Quantitative Method of Measuring Phosphatidylserine Externalization During Apoptosis Using Electron Paramagnetic Resonance (EPR) Spectroscopy and Annexin-Conjugated Iron
Detection of Programmed Cell Death in Cells Exposed to Genotoxic Agents Using a Caspase Activation Assay.

Summary: This title discusses all aspects of non-infectious and non-cancer -- so called NINC -- vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. Practical perspectives of patentability of vaccines are discussed. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.

Contents:
Non-infectious and non-cancer vaccines
Adjuvants and nanotechnology
In silico and delivery systems
Patenting, manufacturing, registration.

Summary: This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives.

Contents:
Chapter 1. Introduction
Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers
Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices
Chapter 4. Water Compatible Molecularly Imprinted Polymers
Chapter 5. Stimuli Responsive Imprinted DDS
Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery
Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents
Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs
Chapter 9. MIP as Drug Delivery Systems for Special Application
Chapter 10. Outlook.

Summary: "Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field"--Provided by publisher.

Contents:
An introduction to SIRS and the rule of 20 / Rebecca Kirby
Fluid balance / Elke Rudloff and Rebecca Kirby
Blood pressure / Lauren Sullivan
Albumin and colloid osmotic pressure / Adesola Odunayo
Glucose / Natara Loose
Electrolytes / Linda Barton
Acid base status / Jan Kovacic and Ryan Wheeler
Oxygenation and ventilation / Christin Reminga and Lesley King
Coagualation / Andrew Linklater
Red blood cells and hemoglobin / Andrew Linklater and Veronica Higgs
Heart rate, rhythm and contractility / Dennis Burkett
Neurological status / Christine Iacovetta
The renal system / Lee Herold
White blood cells, immune status and antimicrobial stewardship
/ Carol Haak
Gastrointestinal system motility and integrity / Jennifer Klaus
Nutrition / Caroline Tonozzi
Temperature / Conni Wehausen
Drug selection and dosing regimens / Dawn Merton Boothe
Pain management / Armi Pigott
Veterinary nursing care / Heather Darbo and Cheryl Page
Wounds and bandages / Jennifer Devey, Andrew Linklater and Rebecca Kirby
Anesthesia of the critical patient / Sue Leonard.

Summary: "This is the fifth edition of what we hope continues to be a practical textbook for those studying or carrying out the important task of protecting workers from hazards. The previous edition was published in 2010, and that built upon work by Indira Ashton and Frank Gill going back to the first edition published in 1982. In that near 40 year span the book has developed considerably and has expanded to include hazards such as nanoparticles and exposure routes including skin contact and inadvertent ingestion of chemicals that were not considered in the first work. Since the 4th Edition published in 2010, new chemical regulations (REACH) have become increasingly widely adopted in Europe. Hazard assessment procedures under REACH often require the generation of robust exposure data, thus stimulating the need to measure or model exposure to chemicals"-- Provided by publisher.

Contents:
Front Matter
INTRODUCTION. Occupational Hygiene and Risk Assessment
Identifying Hazards
Exposure, Exposure Routes and Exposure Pathways
The Exposure Context
Modelling Exposure
Why Measure?
How to Carry Out a Survey
Analysis of Measurement Results
Introduction to Control
The Importance of Good Records and How to Write a Survey Report
Risk Assessment
Risk Communication
HAZARDOUS SUBSTANCES. An Introduction to Hazardous Substances
Dust, Particles and Fibrous Aerosols
Gases and Vapours
Bioaerosols
Dermal and Inadvertent Ingestion Exposure
Human Biomonitoring
PHYSICAL AGENTS. An Introduction to Physical Agents
Noise
Vibration
Heat and Cold
Lighting
Ionising Radiation
Non-Ionising Radiation
CONTROL OF HAZARDS. Assessing the Effectiveness of Exposure Controls
Assessing Local Ventilation Control Systems
Personal Protective Equipment
THE FUTURE. Monitoring for Hazards at Work in the Future
Appendix: Survey Checklists
Equipment Suppliers
Chemical Analytical Services
Index

Summary: This is an introduction to the patient monitoring technologies that are used in today's acute care environments, including the operating room, recovery room, emergency department, intensive care unit, and telemetry floor. To a significant extent, day-to-day medical decision-making relies on the information provided by these technologies, yet how they actually work is not always addressed during education and training. The editors and contributors are world-renowned experts who specialize in developing, refining, and testing the technology that makes modern-day clinical monitoring possible. Their aim in creating the book is to bridge the gap between clinical training and clinical practice with an easy to use and up-to-date guide. ·How monitoring works in a variety of acute care settings ·For any healthcare professional working in an acute care environment ·How to apply theoretical knowledge to real patient situations ·Hemodynamic, respiratory, neuro-, metabolic, and other forms of monitoring ·Information technologies in the acute care setting ·New and future technologies.

Contents:
Section I. Fundamental Principles of Monitoring
Overview of Clinical Monitoring
Monitoring in Acute Care Environments: Unique Aspects of Intensive Care Units, Operating Rooms, Recovery Rooms, Telemetry Floors
Introduction to Signals
Signal Analysis: Acquisition, Storage, and Analysis of Physiological Signals
Information Displays and Ergonomics
Decision Support and Closed-Loop Systems
Section II. Hemodynamic Monitoring
Introduction to Hemodynamic Monitoring
Pulmonary Artery Catherization
Non-invasive Cardiac Output Monitoring
Transpulmonary Thermodilution
Echocardiography in the Acute Care Setting
Non-invasive Arterial Pressure Monitoring
Heart Rate Variability
Preload-Dependent Monitoring
Monitoring the Microcirculation in Critically Ill Patients
Hemodynamic Monitoring During Cardiopulmonary Bypass
Closed-Loop Fluid Management and Hemodynamic Optimization
Section III. Respiratory Monitoring
Introduction to Respiratory Monitoring
Photoplethysmography: Analysis of the Pulse Oximeter Waveform
Time and Volumetric Capnography
Monitoring Diaphragmatic Function
The Anesthesia Machine as a Monitor
Ventilator Settings in Acute Care Environments
Monitoring Respiratory Rate
Closed-Loop Mechanical Ventilation
Section IV. Neuromonitoring
Introduction to Neuromonitoring
Transcranial Doppler
Brain Oxygenation
Intracranial Pressure and SvjO2
Monitoring the EEG for Assessing Depth of Anesthesia
Monitoring Analgesia
Neuromonitoring during Spine Surgery
Closed-loop Anesthesia Based on Neuromonitoring
Target-Controlled Infusions
Section V. Metabolic Monitoring
Glucometrics and Measuring Blood Glucose in Critically Ill Patients
Noninvasive Hemoglobin Monitoring
Monitoring of O2 Uptake and CO2 Elimination During Anesthesia and Surgery
Gastric Tonometry
Temperature Monitoring
Section VI. Other Forms of Monitoring in the Acute Care Environment
Point-of-Care Coagulation Monitoring
Pediatric Monitoring
Fetal Monitoring
Other Forms of Monitoring in the Acute Care Environment
Ultrasound
Section VII. Information Technologies in the Acute Care Setting
Overview of Electronic Health Records
Benefits and Drawbacks of Health Information Technology
Special Case: Perioperative Information Management Systems
Section VIII. New and Emerging Technologies
Intelligent Patient Monitoring and Clinical Decision-Making
Robotization.

Summary: This widely praised, first-of-its-kind book has been thoroughly updated, expanded, and enriched with extensive new case material, illustrations, and link-outs to multimedia, practice guidelines, and more. Written and edited by outstanding world experts, this was the first and remains the leading single-source volume on intraoperative neurophysiological monitoring (IOM). It is aimed at graduate students and trainees, as well as members of the operative team, including anesthesiologists, technologists, neurophysiologists, surgeons, and nurses. Now commonplace in procedures that place the nervous system at risk, such as orthopedics, neurosurgery, otologic surgery, vascular surgery, and others, effective IOM requires an unusually high degree of coordination among members of the operative team. The purpose of the book is to help students, trainees, and team members acquire a better understanding of one another's roles and thereby to improve the quality of care and patient safety. From the reviews of the First Edition: "A welcome addition to reference works devoted to the expanding field of nervous system monitoring in the intraoperative period ... will serve as a useful guide for many different health care professionals and particularly for anesthesiologists involved with this monitoring modality ... An excellent reference ... [and] a helpful guide both to the novice and to the developing expert in this field."--Canadian Journal of Anesthesia "Impressive ... [The book] is well written, indexed, and illustrated ... The chapters are all extensively referenced. It is also very good value at the price ... I would recommend this book to all residents and especially to all neuroanesthesiologists. It will make a worthwhile addition to their library." --Journal of Neurosurgical Anesthesiology.

Contents:
SECTION I. Monitoring Techniques
1. Somatosensory-Evoked Potentials
2. Transcranial Motor-Evoked Potentials
3. Auditory-Evoked Potentials
4. Visual-Evoked Potentials
5. Deep Brain Stimulation
6. Monitoring of Spinal Cord Functions
7. Electromyography
8. The Use of Reflex Responses for IOM
9. Brain and Spinal Cord Mapping
10. EEG Monitoring
11. Clinical Application of Raw and Processed EEG
12. A Guide to Central Nervous System Near-Infrared Spectroscopic Monitoring
13. Transcranial Doppler Ultrasound
14. Monitoring of Jugular Venous Oxygen Saturation
15. Intracranial Pressure Monitoring
16. IOM Instrumentation Layout and Electrical Interference
17. Signal Optimization in Intraoperative Neuromonitoring
SECTION II. Anesthesia Considerations
18. Anesthesia for Awake Neurosurgery
19. Anesthesia Management and Intraoperative Electrophysiological Monitoring
SECTION III. Clinical Applications
20. Monitoring Applications and Evaluating Changes
21. Intraoperative Neurophysiological Monitoring for Intracranial Aneurysm Surgery
22. Intracranial Arteriovenous Malformation Surgery
23. Intraoperative Neurophysiologic Monitoring During Surgery for Supratentorial Mass Lesions
24. Surgery for Infratentorial Mass
25. Trigeminal Microvascular Decompression
26. Surgery for Hemifacial Spasm
27. Skull Base Surgery
28. Surgery for Chiari Type I Malformation
29. ENT and Anterior Neck Surgery
30. Carotid Surgery
31. Anterior Cervical Spine Surgery
32. Posterior Cervical Spine Surgery
33. Surgery for Scoliosis Correction
34. Neurophysiological Monitoring in Thoracic Spine Surgery
35. Intraoperative Neurophysiologic Monitoring for Lumbo-Sacral Spine Procedures
36. Intramedullary Spinal Cord Surgery
37. Intraoperative Monitoring in Tethered Cord Surgery
38. Surgery in the Peripheral Nervous System
39. Surgery of the Aortic Arch
40. Electrophysiological Monitoring During Thoracic Aortic Aneurysm Surgery
41. Monitoring During Cardiopulmonary Bypass
42. Interventional Neuroradiology
43. Intra-operative Neuromonitoring in Pediatric Surgery
SECTION IV. Intensive Care
44. Monitoring in the Intensive Care Unit
45. Epilepsy and Seizures: OR and ICU Applications of EEG
46. Monitoring Cerebral Blood Flow.

Summary: Monitoring Vesicular Trafficking in Cellular Responses to Stress, Volume 164-165 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

Contents:
Antigen production for monoclonal antibody generation / Giovanni Magistrelli and Pauline Malinge
Method for the generation of antibodies specific for site and posttranslational modifications / Hidemasa Goto and Masaki Inagaki
Immunization, hybridoma generation, and selection for monoclonal antibody production / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo
Hybridoma technology for the generation of rodent mAbs via classical fusion / Efthalia Chronopoulou [and three others]
Generation of rabbit monoclonal antibodies / Pi-Chen Yam and Katherine L. Knight
Screening hybridomas for cell surface antigens by high-throughput homogeneous assay and flow cytometry / Alejandro Uribe-Benninghoff [and four others]
Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker / Suba Dharshanan and Cheah Swee Hung
Design and generation of synthetic antibody libraries for phage display / Gang Chen and Sachdev S. Sidhu
Selection and screening using antibody phage display libraries / Patrick Koenig and Germaine Fuh
Yeast surface display for antibody isolation : library construction, library screening, and affinity maturation / James A.Van Deventer and Karl Dane Wittrup
Human B cell immortalization for monoclonal antibody production / Joyce Hui-Yuen, Siva Koganti, and Sumita Bhaduri-McIntosh
Using next-generation sequencing for discovery of high- frequency monoclonal antibodies in the variable gene repertoires from immunized mice / Ulrike Haessler and Sai T. Reddy
Cloning, reformatting, and small-scale expression of monoclonal antibody isolated from mouse, rat, or hamster hybridoma / Jeremy Loyau and François Rousseau
Cloning of recombinant monoclonal antibodies from hybridomas in a single mammalian expression plasmid / Nicole Müller-Sienerth [and three others]
Monoclonal antibody purification by ceramic hydroxyapatite chromatography / Larry J. Cummings, Russell G. Frost, and Mark A. Snyder
Rapid purification of monoclonal antibodies using magnetic microspheres / Pauline Malinge and Giovanni Magistrelli
Generation of cell lines for monoclonal antibody production / Krista Alvin and Jianxin Ye
Expression and purification of recombinant antibody formats and antibody fusion proteins / Martin Siegemund [and four others]
Purification of antibodies and antibody fragments using CaptureSelect [trademark] affinity resins / Pim Hermans, Hendrik Adams, and Frank Detmers
Reformatting of scFv antibodies into the scFv-Fc format and their downstream purification / Emil Bujak [and three others]
Antibody V and C domain sequence, structure, and interaction analysis with special reference to IMGT® / Eltaf Alamyar [and three others]
Measuring antibody affinities as well as the active concentration of antigens present on a cell surface / Palaniswami Rathanaswami
Determination of antibody structures / Robyn L. Stanfield
Affinity maturation of monoclonal antibodies by multi-site- directed mutagenesis / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo
Epitope mapping with membrane-bound synthetic overlapping peptides / Terumi Midoro-Horiuti and Randall M. Goldblum
Epitope mapping by epitope excision, hydrogen/deuterium exchange, and peptide-panning techniques combined with in silico analysis/ Nicola Clementi [and five others]
Fine epitope mapping based on phage display and extensive mutagenesis of the target antigen / Gertrudis Rojas
Epitope mapping with random phage display library / Terumi Midoro-Horiuti and Randall M. Goldblum
Epitope mapping of monoclonal and polyclonal antibodies using bacterial cell surface display / Anna-Luisa Volk, Francis Jingxin Hu, and Johan Rockberg
Ion exchange-high-performance liquid chromatography (IEX-HPLC) / Marie Corbier, Delphine Schrag, and Sylvain Raimondi
Size exclusion-high-performance liquid chromatography (SEC-HPLC) / Delphine Schrag, Marie Corbier, and Sylvain Raimondi
N-glycosylation characterization by liquid chromatography with mass spectrometry / Song Klapoetke
Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization / Stefanie Derer [and six others]
Labeling and use of monoclonal antibodies in immunofluorescence : protocols for cytoskeletal and nuclear antigens / Christoph R. Bauer
Generation and use of antibody fragments for structural studies of proteins refractory to crystallization / Stephen J. Stahl, Norman R. Watts, and Paul T. Wingfield
Antibody array generation and use / Carl A.K. Borrebaeck and Christer Wingren.

Summary: Intended to promote a more appropriate and modern therapeutic approach to migraine management, this book is the first to deal with monoclonal antibodies in this context. Authored by the most respected migraine experts from around the globe and drawing on the lessons learned in both clinical trials and clinical practice, it reviews the current state of knowledge on this important therapeutic innovation, which has produced impressive data in randomized controlled trials, and the efficacy and safety of which have been confirmed in day-to-day real-world use. Given its scope, the book will appeal to a broad range of specialists, including pharmacologists, clinical pharmacologists, neurologists and internists, but also to residents and medical students.

Contents:
The CGRP family of neuropeptides and their receptors in the trigeminovascular system
Pharmacology; where do the mAbs act, gepants vs mAbs
Monoclonal Antibody Biology
Guidelines for clinical trials
Human Models
CGRP Antibodies for Animal Models of Primary and Secondary Headache Disorders
Galcanezumab
Eptinezumab
Erenumab
Fremanezumab
Potential side effects and pregnancy
Real-world data, clinical practice so far
Migraine vs Cluster headache and potential other indications.

Summary: This second edition provides a comprehensive list of the latest taxonomy including the updated relevant plant data. All succulent species of the monocotyledonous plant families and genera are described in detail. This work will be particularly useful to botanists, plant taxonomists and scholars as well as to herbaria and botanic gardens. It will also appeal to the committed collector of succulent plants, horticultural cognoscenti and succulent plant lovers. -- Provided by publisher.

Summary: This book provides essential information on the morphology, biology, phytochemistry, pharmaceutical prospects, evolution, phylogeny, biogeography, and taxonomy of Paris (Melanthiaceae), a morphologically distinctive plant genus with great economic importance. Since the establishment of this genus, 70 species and 24 subspecific taxa have been described, resulting in considerable confusion in species delimitation. In this book, the taxonomy of all described taxa is carefully revised. Based on multi-disciplinary evidences, a revised classification system of Paris containing five sections is outlined. Every species is provided with a concise but diagnostic description, a color illustration, photographs that highlight distinguishing characters, examined specimens and distribution range. The interspecific relationships are clarified with an identification key. This monograph offers taxonomists, evolutionary biologists, ecologists, horticulturalists, phytochemists, and practitioners a thorough and up-to-date overview about this interesting plant group. It is equally valuable for undergraduate and graduate students, teachers and professionals engaged in related fields.

Contents:
Intro
Preface
Acknowledgements
Contents
Chapter 1: Introduction: Taxonomic History
1.1 Establishment of the Genus
1.2 Affinities
1.3 History of Species Discoveries
1.4 Generic Circumscription and Subdivision
1.5 Issues to Be Resolved
References
Chapter 2: Morphology
2.1 Gross Morphology
2.1.1 Rhizome
2.1.2 Mycorrhiza
2.1.3 Leaves
2.1.4 Flower
2.1.5 Fruit
2.1.6 Seeds
2.1.7 Taxonomic Significance
2.2 Pollen Morphology
2.2.1 Pollen Size, Shape, and Ornamentation
2.2.2 Taxonomic Implications
References
Chapter 3: Biology 3.1 Distribution and Habitat
3.2 Phenology
3.3 Propagation and Growth
3.3.1 Pollination
3.3.2 Seed Production
3.3.3 Seed Dispersal
3.3.4 Life Cycle
3.4 Chromosomes
3.4.1 Karyotype
3.4.2 B Chromosomes
3.4.3 Chromosome Evolution
3.5 Genomes
3.5.1 Genome Size
3.5.2 Possible Mechanisms Underlying the Formation of Large Genomes
3.5.3 Plastid Genomes
3.5.3.1 General Features
3.5.3.2 Pseudogenization of Plastid cemA
3.5.3.3 Hotspots of Sequence Variation
References
Chapter 4: Economic Importance
4.1 Medicinal Importance 4.1.1 Overall Information
4.1.2 Traditional Uses and Ethnopharmacological Properties
4.2 Horticultural Potential
4.2.1 P. cronquistii (Takht.) H. Li
4.2.2 P. delavayi Franch
4.2.3 P. lancifolia Hayata
4.2.4 P. luquanensis H. Li
4.2.5 P. marmorata Stearn
4.2.6 P. yunnanensis Franch
4.3 Phytochemistry
4.3.1 Steroidal Saponins
4.3.2 Phytoecdysones
4.3.3 Phytosterols
4.3.4 Flavonoids
4.3.5 Triterpenoid Saponins
4.3.6 Others
4.4 Pharmaceutical Prospects
4.4.1 Anti-Tumor
4.4.2 Hemostatic Activity
4.4.3 Uterine Contractile Agonistic Activity 4.4.4 Antimicrobial
4.4.5 Other Activities
References
Chapter 5: Phylogeny, Classification, Biogeography, and Evolution
5.1 Ancient and Recent Hybridization
5.2 Generic Circumscription
5.3 Infrageneric Classification
5.4 Historical Biogeography
5.5 Species Diversification
5.6 Origin and Evolution of Genomic Gigantism
References
Chapter 6: Taxonomic Revision
6.1 Section Paris
6.2 Section Kinugasa
6.3 Section Thibeticae
6.4 Section Axiparis
6.5 Section Euthyra
References
Chapter 7: Conservation Considerations
7.1 Conservation Status 7.1.1 Species Rarity
7.1.2 Extinction Risk
7.2 Principal Threats
7.2.1 Commercial Collecting
7.2.2 Arbitrary Introduction
7.2.3 Habitat Degradation
7.3 Conservation Priorities
7.4 Conservation Strategies
7.4.1 Commercial Cultivation
7.4.2 In situ Conservation
7.4.3 Ex situ Conservation
References

Contents:
vol.
1. Protospathidiidae, Arcuospathidiidae, Apertospathulidae --

Contents:
Foreword
1. Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes
2. Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants
3. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions
4. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1
5. Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples With Single Substrates
6. Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and their Role in Cardiovascular Disease
7. Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s
8. Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates,- 9. Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources
10. Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs
11. Biological Diversity of Cytochrome P450 Redox Partner Proteins
12. Cytochrome P450cin (CYP176A1)
13. Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins that Combine Peroxidase and Cytochrome P450 Properties.

Contents:
Part I: Perioperative care. Surgical history and physical examination
Fluids and electrolytes
Nutrition
Wound healing
Surgical risk assessment
Suture types, needle types, and instruments
Part II: Anesthesia. Local anesthesia
Conscious sedation
Part III: Surgical critical care. Surgical infection
Hemorrhage and coagulation
Shock
Cardiopulmonary monitoring
Mechanical ventilation
Part IV: Trauma surgery. Primary and secondary survey
Abdominal trauma
Thoracic trauma
Extremity trauma
Burns
Neurosurgical emergencies
Part V: Gastrointestinal surgery. Acute abdomen
Abdominal wall hernias
Gastrointestinal bleeding
Intestinal obstruction
Peptic ulcer disease
Inflammatory bowel disease
Benign colorectal disease
Appendix
Benign pancreatic disease
Bariatric surgery
Part VI: Surgical oncology. Tumor biology, syndromes, and genetic mutations
Head and neck malignancy
Esophageal malignancy
Gastric malignancy
Small bowel malignancy
Malignant colorectal and perianal disease
Malignant pancreas disease
Diseases of the breast
Malignant skin lesions
Part VI: Hepatobiliary surgery. Malignant gallbladder and biliary tree
Liver tumors
Part VIII: Transplant surgery. Renal transplantation
Liver transplantation
Pancreas transplantation
Part IX: Endocrine surgery. Thyroid
Parathyroid
Adrenal gland
Neuroendocrine tumors
Part X: Vascular surgery. Thromboembolic disease
Aneurysms
Peripheral vascular disease
Carotid disease
Mesenteric ischemia
Dialysis access
Diabetic patient
Part XI: Dardiothoracic surgery. Benign tumors of the lung
Malignant tumors of the lung
Thymus and mediastinal tumors
Cardiac surgery
Cardiac transplantation
Part XII: Surgical subspecialties. General pediatric surgery
Neurosurgery
Orthopedic surgery
Plastic surgery: breast reconstruction
Part XIII: Future of surgery. Robotics and new surgical technologies
Part XIV: Procedures.
Part XV: Rapid references.

Summary: "Mood disorders are the most common mental illnesses with a lifetime prevalence of up to 20% worldwide 1. Major depressive disorder (MDD) and Bipolar Disorder (BD) are significant health problems in the US and worldwide 2. In the United States alone, the lifetime prevalence of MDD is up to 17%, and that of BD about 2.1% 2 that can go up to 4% of individuals with mood episodes not meeting episodic criteria are included. Both are chronic and recurrent illnesses characterized by recurrent episodes of depression and mania and depression in MDD and BD respectively"-- Provided by publisher.

Contents:
What is protein moonlighting and why is it important? / Constance J. Jeffery
Exploring structure-function relationships in moonlighting proteins / Sayoni Das, Ishita Khan, Daisuke Kihara, Christine Orengo
Overview of protein moonlighting in bacterial virulence / Brian Henderson
Moonlighting proteins as cross-reactive autoantigens / Wim van Eden
Chaperonin 60 paralogues in mycobacterium tuberculosis and tubercle formation / Brian Henderson
Legionella pneumophila chaperonin 60 an extra- and intra-cellular moonlighting virulence-related factor / Karla N. Valenzuela-Valderas, Angela L. Riveroll, Peter Robertson, Lois E. Murray, and Rafael A. Garduño
An overview of peptidylprolyl isomerases in bacterial virulence / Brian Henderson
GAPDH : a multifunctional moonlighting protein in eukaryotes and prokaryotes / Michael A. Sirover
Streptococcus pyogenes GAPDH : a cell surface major virulence determinant / Vijay Pancholi
Group B streptococcus GAPDH and immune evasion / Paula Ferreira and Patrick Trieu-Cuot
Mycobacterium tuberculosis cell surface gapdh functions as a transferrin receptor / Vishant M Borradia, Manoj Raje, Chaaya Iyengar
Gapdh and probiotic organisms / Hideki Kinoshita
Impact of streptococcal enolase in virulence / Marcus Fulde and Simone Bergmann
Streptococcal enolase and immune evasion / Masaya Yamaguchi and Shigetada Kawabata
Borrelia burgdorferi enolase and plasminogen binding / Catherine A. Brissette
Triosephosphate isomerase from staphylococcus aureus and plasminogen receptors on microbial pathogens / Reiko Ikeda, Tomoe Ichikawa
Moonlighting functions of bacterial fructose-1,6 bisphosphate-aldolases / Neil J Oldfield, Fariza Shams, Karl G Wooldridge and David PJ Turner
Pyruvate dehydrogenase and plasminogen binding in mycoplasmas / Anne Gründel, Kathleen Friedrich, Melanie Pfeiffer, Enno Jacobs, Roger Dumke
Unexpected interactions of leptospiral ef-tu proteins / Natalia Salazar and Angela Barbosa
Mycobacterium tuberculosis antigen 85 family proteins : mycolyl transferases and matrix-binding adhesins / Christopher P. Ptak, Chih-Jung Kuo, and Yung-Fu Chang
Miscellaneous il-1[beta]-binding proteins of aggregatibacter actinomycetemcomitans / Riikka Ihalin
Bacteriophage moonlighting in the control of bacterial pathogenicity / Janine Bowring, Alberto Marina, José R. Penadés and Nuria Quiles-Puchalt
Viral entry glycoproteins and viral immune evasion / Jonathan D. Cook and Jeffrey E. Lee.

Contents:
Overview and Basic Concepts
Back
Upper Limb
Thorax
Abdomen
Pelvis and Perineum
Lower Limb
Head
Neck
Summary of Cranial Nerves.

Summary: "Known for its hallmark Clinical Blue Boxes, Moore's Essential Clinical Anatomy, 7th Edition, combines an easy-to-read approach, dynamic surface anatomy and medical imaging features, and engaging digital resources to build clinical confidence and equip users for success from foundational science courses through clinical training and practice. The concise, user-friendly format emphasizes structures and functions critical to physical diagnosis for primary care, interpretation of diagnostic imaging, and understanding the anatomical basis of emergency medicine and general surgery. This updated 7th Edition reflects the latest clinical perspectives and is supported by valuable self-assessment tools, case studies, and interactive BioDigital software to enrich understanding for students and practitioners alike. NEW! Sex and gender content clarifies important gender considerations and reflects an equitable focus on female as well as male anatomy. Extensively revised Clinical Blue Boxes highlight the practical applications of anatomy, accompanied by helpful icons, illustrations, and images that distinguish the type of clinical information covered. Revised comprehensive surface anatomy photographs ensure accurate, effective physical examination diagnoses with integrated natural views of unobstructed surface anatomy and illustrations superimposing anatomical structures with landmarks for more accurate physical examination. Insightfully rendered, anatomically accurate illustrations, combined with many photographs and medical images, strengthen comprehension of anatomical concepts and retention of "mental images" of anatomical structures. Medical Imaging sections familiarize students with plain and contrast radiographic, MRI, CT, and ultrasonography studies they'll use in clinical practice. Comprehensive tables clarify complex information about muscles, veins, arteries, nerves, and other structures for easy study and review. "-- Provided by publisher.

Summary: "Twenty-two years have passed since the first edition of Essential Clinical Anatomy was published. The main aim of the sixth edition is to provide a compact yet thorough textbook of clinical anatomy for students and practitioners in the health care professions and related disciplines. With each edition, we strive to make the book even more student friendly. This edition has been thoroughly revised, keeping in mind the many invaluable comments received from students, colleagues, and reviewers"--Provided by publisher.

Contents:
Overview and basic concepts
Back
Upper limb
Thorax
Abdomen
Pelvis and perineum
Lower limb
Head
Neck
Review of cranial nerves.

Contents:
Machine generated contents note: SECTION 1 Introduction
1.A History of Vascular Surgery / Wiley F. Barker
2.Embryology of the Vascular System / David S. Maxwell
SECTION 2 General Principles
3.Anatomy, Physiology, and Pharmacology of the Vascular Wall / Ted R. Kohler
4.Anatomy and Surgical Exposure of the Vascular System / Todd L. Rasmussen
5.Hemodynamics for the Vascular Surgeon / R. Eugene Zierler
6.Hemostasis and Thrombosis / Thomas G. DeLoughery
7.Atherosclerosis: Pathology, Pathogenesis, and Medical Management / Jessica Beth O'Connell
8.Nonatherosclerotic Vascular Disease / Gregory J. Landry
9.Venous Vascular Malformations / Peter Gloviczki
10.Congenital Arterial Malformations / Daiva Nevidomskyte
11.Antibiotic Prophylaxis in Vascular Disease Management / Taimur Saleem
12.Patterns of Diabetic Vascular Disease / Joseph L. Mills
13.Medical Management of Vascular Disease
Including Pharmacology of Drugs Used in Vascular Disease Management / Jessica Beth O'Connell
14.Noninvasive Vascular Diagnostic Laboratory / J. Dennis Baker
15.Principles of Imaging in Vascular Disease / Antoinette S. Gomes
SECTION 3 Arterial Occlusive Disease
16.Vascular Grafts: Characteristics and Rational Selection / Alik Farber
17.Introduction to Endovascular Surgery: Arterial Access, Guidewires, Catheters, Sheaths Angioplasty Catheters, and Stents / Alan B. Lumsden
18.Atherectomy and Arterial Closure Devices: Selection, Technique, and Results / Donald T. Baril
19.Extracranial Cerebrovascular Disease: The Carotid Artery / Wesley S. Moore
20.Surgical Reconstruction of the Supra-Aortic Trunks and Vertebral Arteries / Enrique Criado
21.Endovascular Repair of Extracranial Cerebrovascular Lesions / Peter A. Schneider
22.Carotid Body Tumors: Diagnosis and Surgical Management / Rameen S. Moridzadeh
23.Surgical Management of Aortoiliac Occlusive Disease / Michael Belkin
24.Angioplasty and Stenting for Aortoiliac Disease: Technique and Results / William D. Jordan, Jr.
25.Diagnosis and Surgical Management of the Visceral Ischemic Syndromes / Bruce L. Gewertz
26.Diagnosis and Management of Renal Vascular Occlusive Disease / Benjamin J. Pearce
27.Angioplasty and Stenting for Mesenteric and Renal Artery Disease / Emanuel Junio R. Tenorio
28.Surgical Management of Femoral, Popliteal, and Tibial Arterial Occlusive Disease / Enrico Ascher
29.Endoscopic Harvesting of the Saphenous Vein / Christian Eisenring
30.Infrainguinal Endovascular Reconstruction: Technique and Results / Peter A. Schneider
31.Endovascular Repair of Infrapopliteal Arterial Occlusive Disease / Joseph L. Mills
32.Thoracic and Lumbar Sympathectomy: Indications, Technique, and Results / Peter Gloviczki
33.Thoracic Outlet Syndrome and Vascular Disease of the Upper Extremity / David A. Rigberg
34.Natural History and Nonoperative Treatment of Chronic Lower Extremity Ischemia / Gregory L. Moneta
35.Thrombolysis for Arterial and Graft Occlusions: Technique and Results / Vikram Kashyap
SECTION 4 Arterial Aneurysm Disease
36.Descending Thoracic and Thoracoabdominal Aortic Aneurysms: General Principles and Open Surgical Repair / Hazim J. Safi
37.Endovascular Repair of Thoracic Aortic Aneurysm / Michel S. Makaroun
38.Combined Endovascular and Surgical (Hybrid) Approach to Aortic Arch and Thoracoabdominal Aortic Pathology / William J. Quinones-Baldrich
39.Fenestrated-Branched and Parallel Stent-Grafts for Endovascular Repair of Aortic Arch and Thoracoabdominal Aortic Aneurysms / Giuliano de A. Sandri
40.Acute and Chronic Aortic Dissection: Medical Management, Surgical Management, Endovascular Management, and Results / Benjamin W. Starnes
41.Aneurysms of the Aorta and Iliac Arteries / Jerry Goldstone
42.Endovascular Repair of Juxtarenal (Chimney), Infrarenal, and Iliac Artery Aneurysms / Ronald M. Fairman
43.Open Surgical and Endovascular Management of Ruptured Abdominal Aortic Aneurysm / Mario Lachat
44.Laparoscopic Aortic Surgery for Aneurysm and Occlusive Disease: Technique and Results / Catherine Cagiannos
45.Building a Hybrid Operating Suite Including Robotic Capability / Alan B. Lumsden
46.Splanchnic and Renal Artery Aneurysms / Jonathan L. Eliason
47.Aneurysms of the Peripheral Arteries / Fred A. Weaver
48.Surgical and Endovascular Management of Vascular Trauma Including Aortic Transection / David L. Gillespie
SECTION 5 Venous Disease
49.Venous Thromboembolic Disease / Thomas Wakefield
50.Thrombolysis and Mechanical Thrombectomy for Deep Venous Thrombosis and Pulmonary Embolism / Maxim L. Shaydakov
51.Surgical Management of Chronic Venous Obstruction / Ying Huang
52.Endovascular Repair of Chronic Venous Obstruction / Arjun Jayaraj
53.Etiology and Management of Varicose Veins: Surgery, Endovenous Ablation, and Sclerotherapy / David A. Rigberg
54.Management of Venous Leg Ulcers / Steven M. Farley
55.Portal Hypertension / Hugh A. Gelabert
56.Lymphedema / Thorn W. Rooke
57.Hemodialysis and Vascular Access / Ahmed Kayssi
SECTION 6 Complications in Vascular Surgery
58.Neointimal Hyperplasia / Melina R. Kibbe
59.Prosthetic Graft Infection / Julie Ann Freischlag
60.Noninfectious Complications in Vascular Surgery / Juan Carlos Jimenez
61.Management of Complications After Endovascular Abdominal Aortic Aneurysm Repair / Sharif H. Ellozy
SECTION 7 Miscellaneous Topics
62.Diabetic Foot Complications: A Primer for Vascular Surgeons / Joseph L. Mills
63.The Wound Care Center and Limb Salvage / Steven M. Farley
64.Lower Extremity Amputation / Juan Carlos Jimenez
65.Anterior Spine Exposure: Operative Techniques for the Vascular Surgeon / William J. Quinones-Baldrich
66.Carotid Sinus Stimulation: Background, Technique, and Future Directions / John D. Bisognano.

Summary: "This is the first book on the market or within academia dedicated solely to moral distress among health professionals. It aims to bring conceptual clarity about moral distress and distinguish it from related concepts. Explicit attention is given to the voices and experiences of health care professionals from multiple disciplines and many parts of the world. Contributors explain the evolution of the concept of moral distress, sources of moral distress including those that arise at the unit/team and organization/system level, and possible solutions to address moral distress at every level. A liberal use of case studies will make the phenomenon palpable to readers. This volume provides information not only for academia and educational initiatives, but also for practitioners and the research community, and will serve as a professional resource for courses in health professional schools, bioethics, and business, as well as in the hospital wards, intensive care units, long-term care facilities, hospice, and ambulatory practice sites in which moral distress originates."--Publisher's description.

Contents:
What We Know About Moral Distress / Lynn Musto, Patricia Rodney
Healthcare Professional Narratives on Moral Distress: Disciplinary Perspectives / Anne J. Davis, Marsha Fowler, Sophia Fantus, Joseph J. Fins, Michelle Joy, Katherine Kruse, Alyssa Burgart, Margaret Lindsey, Kim Mooney-Doyle, Tanya Uritsky, and Christine Grady
A Broader Understanding of Moral Distress / Stephen M. Campbell, Connie M. Ulrich, Christine Grady
Sources of Moral Distress / Mary K. Walton
Building Compassionate Work Environments: The Concept of and Measurement of Ethical Climate / Linda L. Olson
Moral Distress Research Agenda / Carol L. Pavlish, Ellen M. Robinson, Katherine Brown-Saltzman, Joan Henriksen
International Perspectives on Moral Distress / Connie M. Ulrich, An Lievrouw, Bo Van den Bulcke, Dominique Benoit, Ruth Piers, Georgina Morley, Renatha Joseph, Baraka Morris, Subadhra D. Rai, and Margaret Mei Ling Soon
Reflections on Moral Distress and Moral Success / Christine Grady, Nancy Berlinger, Arthur Caplan, Sheila Davis, Ann B. Hamric, Shaké Ketefian, Robert Truog, and Connie M. Ulrich.

Summary: As the worldwide prevalence of morbid obesity among adolescents continues to rise, recent years have seen a large increase in the performance of adolescent bariatric surgery. While surgical intervention often becomes necessary when conservative weight-loss therapies have failed, no standards regarding the post-operative regimen and long-term management of adolescent patients have been established. Thus, the treatment of obesity and its co-morbidities requires a multidisciplinary approach, taking into account epidemiological, clinical, nutritional, and genetic aspects of morbid obesity in the pediatric age group. This volume discusses both conventional therapy and surgical options for morbid obesity in the pediatric age group. In the first part, obesity-related diseases, genetics, and psychological factors are analyzed. The second part focuses on current bariatric surgery procedures, including dietary restrictions and guidelines to prevent nutritional deficiencies common after surgery. Therefore, the book will prove an invaluable resource for pediatricians, surgeons, nutritionists, dieticians, and all other health professionals who treat adolescent obesity.

Contents:
Paediatric Body Composition Measurement Techniques in Morbidly Obese Patients
Insulin Resistance in the Morbidly Obese Adolescent
Inflammation as a Trigger for Insulin Resistance and Cardiometabolic Disease
Inpatient Lifestyle Interventions to Treat Childhood Obesity
Conservative Treatment for Morbidly Obese Adolescents: The German Experience
Comorbidities: Non Alcoholic Fatty Liver in Childhood Obesity
Measurement of Atherosclerosis in Morbidly Obese Adolescents
Arthritis and Joint Problems in Morbidly Obese Adolescents
Bariatric Surgery in Adolescents: Practical Guidelines from a Pediatrician{u2019}s Point of View
Vitamin Deficiencies After Bariatric Surgery?
Laparoscopic Gastric Banding
Metabolic Surgery in Adolescents
Situation in Sweden
Experiences from Adolescents at the Viennese Center for Bariatric Surgery
Is There an Indication for BPD-DS/BPD? What the Potential Advantages/Disadvantages to RYNGB?
Psychological, Nutritional and Sports-Scientific Aspects of Obesity in Adolescence
Current Guidelines of Bariatric Surgery in Adolescents
Cardiovascular Risk in Childhood Obesity.

Summary: This book reveals the numerous ways in which moral, ethical and legal principles are being violated by those who provide, recommend or sell ‘complementary and alternative medicine’ (CAM). The book analyses both academic literature and internet sources that promote CAM. Additionally the book presents a number of brief scenarios, both hypothetical and real-life, about individuals who use CAM or who fall prey to ethically dubious CAM practitioners. The events and conundrums described in these scenarios could happen to almost anyone. Professor emeritus of complementary medicine Edzard Ernst together with bioethicist Kevin Smith provide a thorough and authoritative ethical analysis of a range of CAM modalities, including acupuncture, chiropractic, herbalism, and homeopathy. This book could and should interest all medical professionals who have contact to complementary medicine and will be an invaluable reference for patients deliberating which course of treatment to adopt.

Contents:
Medical ethics
Competence
Research
Education
Informed Consent
Truth
Exploitation
Conclusions
Glossary with short explanations of the main alternative therapies.

Summary: "Mary Bennet Ritter was a farmer's daughter who in the 1880s defied all conventions to pursure her passion: to receive medical training and become a physician. Ritter's memoir is a riveting account of her accomplishments and a revealing peek into an earlier era through her keen sense of observation, humor, savvy, and her courage to challenge gender norms. It is filled with adventures--house calls via horse and buggy rides through the dark streets of Berkeley, a spurned lover's suicide, a near drowning at Pacific Grove Beach, one of the first automobile rides across rugged California dirt roads, intercontinental rail travel, and voyages to the Far East. As the story unfolds, readers encounter the movers and shakers of the time--University of California presidents and families of wealth and influence, including the Scrippses, the Hearsts, and the Rockefellers"--Back cover.

Contents:
Childhood memories
Youthful days
Undercurrents
An interlude
Medical student and interne
First years in Berkeley
The "ply-wood" of life
University interests
Medical practice
Keeping pace with a biologist
The quest for a southern site
A transitional half-decade
Pioneering in a biological laboratory
The half decade 1913-1918
My war work
The turning of a long lane
Last years in La Jolla
The other side of the world
The South Sea Isles
Retirement
Washington days
Europe again
Sunset and afterglow.

Summary: American science produces the best--and most expensive--medical treatments in the world. Yet U.S. citizens lag behind their global peers in life expectancy and quality of life. Robert Kaplan brings together extensive data to make the case that health care priorities in the United States are sorely misplaced. America's medical system is invested in attacking disease, but not in addressing the social, behavioral, and environmental problems that engender disease in the first place. Medicine is important, but many Americans act as though it were all important. The U.S. stakes much of its health funding on the promise of high-tech diagnostics and miracle treatments, while ignoring strong evidence that many of the most significant pathways to health are nonmedical. Americans spend millions on drugs to treat high cholesterol, for example, which increase life expectancy by six to eight months on average. But they underfund education, which might extend life expectancy by as much as twelve years. Wars on infectious disease have paid off, but clinical trials for chronic conditions--costing billions--rarely confirm that new treatments extend life. By comparison, the National Institutes of Health spends just 3 percent of its budget on research in social and behavioral determinants of health, even though these factors account for 50 percent of premature deaths. America's failure to take prevention seriously costs lives. More than Medicine argues that we need a shake-up in how we invest resources, and it offers a bold new vision for longer, healthier living.-- Provided by publisher.

Contents:
Let's be average
Research promise and practice
Mistaking the meaning of health
Making health care safe and effective
Social determinants of health
The act of well-being
A way forward.

Summary: "Braithwaite and his coauthors, of Morehouse Medical School, describe the collaboration between community organizations and university faculty essential to public health and reliable research. They explain the Morehouse model of outreach in which citizen participation is a critical element for facilitating behavioral change in the community. Through case studies, exploratory research, surveys, and interventions, they provide lessons for advancing participatory research and promoting community health"-- Provided by publisher.

Contents:
Introduction to the Morehouse School of Medicine Model
Social Accountability, Medical Education, and Public Health
Community-Based Participatory Research (CBPR)
Evolution of the Morehouse Model for Community Engagement
Engaging Micropolitan and Rural Communities in Health Promotion and Disease Prevention
Educational and Leadership Development
For Communities, by Communities : The Strategic Engagement of Community Health Workers
The Medical School of Tomorrow.

Summary: This book approaches inner ear diseases from a perspective that is as multifaceted as the diseases themselves. Common among these disorders are sudden deafness, Mnires disease, and perilymphatic fistula. With an awareness of the generally insufficient understanding of the causes and etiologies of these and other inner ear diseases, the author helps to fill those gaps in knowledge. Several factors have impeded a clearer understanding of inner ear diseases, chiefly the small size of the organ and its location in the hard temporal bone and, consequently, the inadequate resolution of CT and MRI images for pathophysiological analysis. This book provides morphological information about the inner ear, elucidating its fluids and blood vessels to help familiarize the reader with the complicated inner ear structures. Important information about how the inner ear responds to various stimuli is also given for a better understanding of the characteristics of the organ. Included are chapters describing specific diseases and animal models of the diseases. Examples and illustrations are presented for surgical applications. For instance, patients with intractable vertigo of inner-ear origin require surgical treatment and the application of a laser to the vestibular labyrinth, described in detail. With its generous use of color photographs, this book is an excellent reference text for all doctors and trainees in the field of otolaryngology.

Contents:
Structure of the Inner Ear
Inner Ear Fluid
Blood Vessels
Sudden Deafness
Menieres Disease
Viral Disease
Laser Surgery
Presbycusis
Anomalies.

Contents:
Blood and bone marrow cells
Erythropoiesis and anaemia
Myelodysplastic syndromes
Acute myeloid leukaemia
Myeloproliferative neoplasms
Hypereosinophilia
Myelodysplastic/myeloproliferative neoplasms
Acute lymphoblastic and mixed phenotype leukaemia
Neoplasms of mature B, T and NK cells
Plasma cell proliferative disorders
Reactive bone marrow changes and non-haemopoietic neoplasms.

Summary: This compelling book examines mortality risk among former Hispanic and African-American players in Major League Baseball (MLB) during the 40-year period following desegregation in the League. Analyzing a variety of biological, cultural, social, and environmental factors, the author illustrates the potential health effects of racial disparities on these elite athletes and fills a significant gap in the mortality literature. Included in the coverage: The history and evolution of professional baseball in both the United States and Latin America Literature and statistical reviews of racial and ethnic inequalities in mortality in the US general population Overview and evaluation of methodologies used to statistically analyze mortality risk in this professional-athlete population Implications and applications of research findings related to Hispanic and African-American MLB-player mortality A unique perspective on a pressing public health issue, Mortality Among Hispanic and African-American Players After Desegregation in Major League Baseball is a salient read for public health professionals including epidemiologists, medical professionals, and social scientists, as well as athletes, historians, and those with broad interest in African American and Latino health.

Contents:
Preface.- List of Tables and Figures.- Part I
The Backstory.- The Roots of Baseball in the US.- A Mini-history of Latin America and Professional Baseball.- Literature and Statistical Review of Race/Hispanic Origin and Mortality.- Part II
Empirical Study Description and Preliminary Results.- Study Methods.- Births and Deaths in the Study Cohort.- Preliminary Testing of Main Study Hypotheses.- Part III
Other Independent Variables and More Definitive Testing of Study Hypotheses.- The Role of Educational Attainment.- Examination of Other Independent Variables.- Final Multivariate Testing of Study Hypotheses.- Part IV
External Analysis and Discussion.- Comparison of Mortality Rates Between Major League Baseball Players and the General Population .- Summary, Conclusions, and Implications.

Summary: Of ResultsDiscussion; References; Chapter 5: Body Mass Index (BMI); Introduction; General Literature Review; The Prevalence and Costs of Obesity; BMI Background; Literature Review of BMI and Mortality in Professional Basketball and Football; Professional Basketball; Professional Football; Methods; Measurement of BMI for This Study; Statistical Plan; Results; Descriptive Statistics; Height and Weight; BMI; Mortality Outcomes by BMI; Vital Status by BMI Categories and League; Cox Models Predicting Mortality Risk Based on BMI.

Contents:
Introduction
Methods
Life and death statistics
Part I. Internal risk factor analysis
Race
Body mass index (BMI)
Birthplace region
Playing experience
Multivariate analysis
Player position
Part II. External analysis
Mortality comparisons between NBA and NFL players versus the general population
Conclusions, implications, and discussion.

Contents:
pt.
1. Congenital cardiovascular malformations.

Summary: Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.

Summary: This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians. .

Contents:
Intro
Preface
Acknowledgments
Contents
1: Introduction
2: Mosaicism as a Biological Concept
2.1 Historical Beginnings
2.2 Mosaicism in Plants
2.3 Mosaicism in Animals
2.4 Mosaicism in Human Skin
2.5 Mosaicism Versus Chimerism
2.6 Does the Coat of Zebras Reflect Mosaicism?
References
3: The Major Categories of Mosaicism
3.1 Nonsegmental Versus Segmental Mosaicism of Autosomal Dominant Skin Disorders
3.1.1 Nonsegmental Mosaicism
3.1.2 Segmental Mosaicism
3.2 Genomic Versus Epigenetic Mosaicism
3.3 Genomic Mosaicism 3.3.1 Genomic Mosaicism of Autosomes
3.3.1.1 Mosaicism Caused by Loss of Heterozygosity
3.3.1.2 Genomic Mosaicism of Lethal Autosomal Mutations
Mosaicism Caused by Lethal Cytogenetic Abnormalities
Mosaicism Caused by Lethal Molecular Defects
3.3.1.3 Genomic Mosaicism of Nonlethal Autosomal Mutations
Simple Segmental Mosaicism of Autosomal Dominant Disorders
Superimposed Mosaicism of Autosomal Dominant Disorders
Monoallelic Versus Biallelic Mosaicism
Disseminated Mosaicism of Biallelic Autosomal Dominant Disorders
Isolated Segmental Biallelic Monoclonal Mosaicism Blue Rubber Bleb Angiomatosis ("Blue Rubber Bleb Nevus Syndrome"): A Unique Type of Postzygotic Mosaicism
3.3.2 Autosomal Recessive Mosaicism
3.3.3 Didymosis (Twin Spotting)
3.3.4 Revertant Mosaicism
3.3.5 Genomic X-Chromosome Mosaicism in Male Patients
3.3.6 Superimposed Segmental Manifestation of Polygenic Skin Disorders
3.4 Epigenetic Mosaicism
3.4.1 Epigenetic Mosaicism of Autosomal Genes
3.4.2 Epigenetic Mosaicism of X Chromosomes
3.4.2.1 Functional X-Chromosome Mosaicism in Female Patients
3.4.2.2 Why Do Women Live Longer? 3.4.2.3 Functional X-Chromosome Mosaicism in Male Patients
3.4.3 X-Linked Genes Escaping Inactivation
References
4: Relationship Between Hypomorphic Alleles and Mosaicism of X-Linked or Autosomal Mutations
4.1 Hypomorphic Alleles and X-Linked Dominant, Male-Lethal Cutaneous Syndromes
4.2 Hypomorphic Alleles in Autosomal Dominant Skin Disorders
References
5: The Archetypical Patterns of Segmental Cutaneous Mosaicism
5.1 Lines of Blaschko
5.1.1 Lines of Blaschko, Narrow Bands
5.1.2 Lines of Blaschko, Broad Bands 5.1.3 Analogy of Blaschko's Lines in Other Organs
5.1.4 Blaschko's Lines in Animals
5.1.5 Analogy of Blaschko's Lines in the Murine Brain
5.2 Flag-like Pattern
5.3 Phylloid Pattern
5.4 Lateralization Pattern
References
6: Less Well-Defined or So Far Unclassifiable Patterns
6.1 Oblique Pattern (Sash-Like Pattern)
6.2 Pallister-Killian Pattern
6.3 Midfacial Pattern
References
7: Nevi
7.1 The Theory of Lethal Genes Surviving by Mosaicism
7.2 Pigmentary Nevi
7.2.1 Melanocytic Nevi
7.2.1.1 Common Small Melanocytic Nevus

Summary: "Choose the drug handbook trusted by nurses for over 35 years! Mosby's 2024 Nursing Drug Reference makes it easy to find the most vital information on the drugs you administer most frequently. More than 5,000 drugs are profiled -- including more than 25 new entries for drugs recently approved by the FDA. And no other drug guide places a higher emphasis on patient safety, with Black Box Warnings for dangerous adverse reactions, High Alerts for drugs with the greatest risk, and a focus on both common and life-threatening side effects. From nursing pharmacology expert Linda Skidmore-Roth, this perennial bestseller proves there is a difference in drug guides. More than 5,000 generic and trade-name drugs are profiled, covering almost every drug you will administer in practice or in clinicals. Alphabetical organization by generic name provides quick and easy access to specific drugs, with both trade and generic names listed in the index. Bolded coverage of IV drug administration highlights dosage and IV administration instructions, including safety considerations and Y-site, syringe, and additive compatibilities. Nursing Process steps are used as the framework for organizing all nursing care information. Complete pharmacokinetic information is summarized in a table and includes the mechanism and absorption of the drug as well as its action, duration, and excretion. Side effects information is organized by body system and identified as common or life threatening, showing signs to watch for during assessments. High Alert headers highlight drugs that pose the greatest risk if administered improperly. Black Box Warnings provide alerts to FDA warnings of dangerous or life-threatening drug reactions. Overview of drug categories explains the safe administration of common classes of drugs, as well as their common side effects and interactions. [...] NEW! Drug monographs for more than 25 newly released, FDA-approved medications equip you with the latest drug information including generic names, trade names, pronunciations, do-not-confuse drugs, action, uses, contraindications, precautions, dosages and routes, side effects, pharmacokinetics, interactions (including drug/herb, drug/food and drug/lab test), nursing considerations, treatment of overdose, patient/family teaching, and more. NEW! Several online-only drug monographs are added to the Evolve website, creating an overall total of more than 100 Evolve-only drug monographs for lesser-used medications." -- Provided by publisher.

Contents:
Individual drug monographs
Appendixes: A. Selected new drugs
B. Ophthalmic, nasal, topical, and otic products
C. Vaccines and toxoids
D. Recent FDA drug approvals.

Summary: Ideal for chairside use by the entire dental team, Mosby's Dental Drug Reference, 11th Edition, provides the current, concise, dental-specific drug information you need at the point of care. More than 850 drug monographs make it easy to find indications and dosages, contraindications, interactions, side effects, serious reactions, and dental considerations. A companion website adds regular drug updates, a full-color pill atlas, printable patient education handouts, reference tables, and more. More than 850 drug monographs offer the vital dental-specific drug information you need. Drug information with relevant patient and family education guidelines in each monograph emphasize oral health, prevention, and treatment from the dental hygiene perspective. Durable and pocket sized, a succinct and organized format makes this guide ideal for chairside use. Bulleted lists provide quick and easy access to general and specific dental-related information in each monograph. .Primers on therapeutic management of common diseases and on medically compromised patients offer key foundational information relevant to the treatment of all patients. New monographs, FDA updates, a color pill atlas, images of common pathologic conditions, patient education handouts, quick-reference guides, and more are available online to help keep this guide compact and user-friendly.

Contents:
Front cover; Evolve page; Anesthesia Color Codes; Mosby's Dental Drug Reference; Copyright page; Drug Monograph Content Contributors and Reviewers; Preface; Table of Contents; About the Companion Website; Therapeutic Management of Common Oral Lesions: Based on Material from the American Academy of Oral Medicine (AAOM) Clinician's Guide to Treatment of Common Oral Conditions; Supportive Care; Herpes Simplex Infection; Primary Herpetic Gingivostomatitis; Etiology:; Clinical description:; Rationale for treatment:; Topical Anesthetics and Coating Agents; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx. Disp. Sig.; Systemic Antiviral Therapy; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Recurrent (Orofacial) Herpes Simplex Infection; Etiology:; Clinical description:; Rationale for treatment:; Prevention; Rx; Disp.; Sig.; Topical Antiviral Agents; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Systemic Antiviral Therapy; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Herpes Zoster (Shingles); Etiology:; Clinical description:; Rationale for treatment:; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Recurrent Aphthous Stomatitis; Etiology:; Clinical description. Rationale for treatment:Topical Steroids; For Mild-to-Moderate Cases:; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Systemic Steroids and Immunosuppressants for Severe Cases; Rx; Disp.; Sig.; Directions for using dexamethasone oral solution:; Rx; Disp.; Sig.; For Very Severe Cases; Rx; Disp.; Sig.; Candidiasis; Etiology:; Clinical description:; Rationale for treatment:; Topical Antifungal Agents; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Systemic Antifungal Agents; Rx; Disp.; Sig.; Rx; Disp. Sig. Systemic Antifungal Agents for Refractory Oropharyngeal Candidiasis; Rx; Disp.; Sig.; Angular Cheilitis; Etiology:; Clinical description:; Rationale for treatment:; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Actinic (Solar) Cheilitis; Etiology:; Clinical description:; Rationale for treatment:; Rx; Geographic Tongue (Benign Migratory Glossitis; Erythema Migrans); Etiology:; Clinical description:; Rationale for treatment:; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig. Xerostomia (Reduced Salivary Flow and Dry Mouth)Etiology:; Clinical description:; Rationale for treatment:; Saliva Substitutes; Rx; Disp.; Sig.; Saliva Stimulants; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Caries Prevention; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Lichen Planus; Etiology:; Clinical description:; Rationale for treatment:; Topical Steroids; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Systemic Steroids and Immunosuppressants for Severe Cases; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.; Rx; Disp.; Sig.

Summary: With this best-selling reference, you will gain quick access to today's most important diagnostic tests and laboratory procedures. Clear, concise test entries are arranged alphabetically and reflect the latest advances in testing and research. Each test includes vital information such as alternate or abbreviated test names, a test description, contraindications, explanations of results, and guidelines to patient care before, during, and after the test. -- From publisher's description.

Contents:
User's guide to test preparation and procedures
Diagnostic and laboratory tests.

Summary: Find oncology information fast with this concise, all-in-one clinical reference! Mosby's Oncology Nursing Advisor, 3rd Edition uses a streamlined format to provide quick access to the most essential information on oncology nursing care. Evidence-based guidelines include topics such as the major cancers, principles of cancer management, and principles of symptom management, as well as oncologic emergencies, palliative care, and nursing practice considerations. This edition includes new information on cancer treatments, genetic risk, chemotherapy guidelines, and more. Written by a team of oncology nursing experts led by Susan Maloney-Newton, this book is ideal for use in any oncology nursing setting. Detailed descriptions of more than 50 major cancer types provide essential information on incidence, etiology and risk factors, signs and symptoms, diagnostic workup, histology, staging, treatment, prognosis, and prevention. Coverage of cancer management principles outlines a wide range of treatment and pharmacologic modalities, including surgery, chemotherapy, radiation therapy, hormonal therapy, immunotherapy, and complementary and alternative therapies. Symptom management guidelines offer in-depth coverage of pathophysiology, signs and symptoms, assessment tools, lab and diagnostic tests, differential diagnoses, interventions, patient education, follow up care, and resources for more than 30 common symptoms associated with cancer and cancer treatments. Essential information on oncologic emergencies and emergent issues prepares readers to respond quickly to structural, urologic, metabolic, and hematologic emergencies. Section on palliative care and end-of-life issues offers helpful guidelines for dealing with topics related to survivorship, palliative care, the final hours of the cancer patient, and loss, grief, and bereavement.

Summary: A concise, pocket-sized study tool and clinical reference based on the best-selling textbook Clinical Nursing Skills & Techniques, 9th Edition! This spiral-bound presents 85 key nursing skills in a convenient, A-to-Z format. Step-by-step instructions include full-color photos plus rationales explaining why and how to use specific techniques to help you troubleshoot potential problems and take appropriate actions to address them. With the latest in evidence-based practice this essential guide is a great tool to help you safely and effectively perform core nursing skills.

Contents:
Acapella device
Apical-radial pulse
Aquathermia and heating pads
Aspiration precautions
Assistive device ambulation (use of crutches, cane, and walker
Automated external defibrillator
Bladder volume measurement
Blood administration
Blood pressure by auscultation: upper extremities, lower extremities, palpation
Blood glucose testing
Blood pressure: automatic
Cardiac monitor: applying
Central venous access device care: central venous catheter, ports
Chest tube care
Cold applications
Condom catheter
Continuous passive motion machine
Continuous subcutaneous infusion
Dressings: dry and moist-to-dry
Dressings: hydrocolloid, hydrogel, foam, or alginate
Dressings: transparent
Ear drop administration
Ear irrigations
Electrocadiogram: obtaining a 12-lead electrocardiogram
Enemas
Enteral nutrition via a gastrostomy or jejunostomy tube
Enteral nutrition via a nasoenteric feeding tube
Epidural analgesia
Eye irrigation
Eye medications: drops and ointment
Fall prevention in a health care facility
Fecal impaction: removing digitally
Hypothermia and hyperthermia blankets
Using incentive spirometery
Intradermal injections
Intramuscular injections
Intravenous medications: intermittent infusion sets and mini-infusion pumps
Intravenous medications: intravenous bolus
Isolation precautions
Mechanical lifts
Metered-dose inhalers
Moist heat (compress and sitz bath)
Mouth care: unconscious or debilitated patients Nail and foot care
Nasoenteral tube: placement and irrigation
Nasogastric tube for gastric decompression: insertion and removal
Negative-pressure wound therapy
Oral medications
Oral medications: medication administration through an external feeding tube
Ostomy care (pouching)
Oxygen therapy: nasal cannula, oxygen mask, T tube, or tracheostomy collar
Parenteral medication preparation: ampules and vials
Parenteral medications: mixing medications in one syringe
Patient-controlled analgesia
Peripheral intravenous care: dressing care, discontinuation
Peripheral intravenous care: regulating intravenous flow rate, changing tubing and solution
Peripheral intravenous insertion
Peripherally inserted central catheter care
Preoperative teaching
Pressure bandages (applying)
Pressure injury risk assessment
Pressure injury treatment
Pulse oximetry
Rectal suppository insertion
Respiration assessment
Restraint application
Restraint-free environment
Seizure precautions
Sequential compression device and elastic stockings
Specialty beds: air-fluidized, air-suspension, and rotokinetic
Sterile gloving
Sterile technique: donning and removing cap, mask, and protective eyewear
Subcutaneous injections
Suctioning: closed (in-line)
Suctioning: nasopharyngeal, nasotracheal, and artificial airway
Suprapubic catheter care
Suture and staple removal
Topical skin applications
Tracheostomy care
Urinary catheter insertion
Urinary catheter care and removal
Urinary catheter irrigation
Urinary diversion: pouching an incontinent urinary diversion
Vaginal instillations
Venipuncture: collecting blood specimens and cultures by syringe and vacutainer method
Managing wound drainage evacuation
Wound irrigation
Appendix: Overview of CDC hand hygiene guidelines.

Contents:
V. I: Sect. I: From the gene to the neonate
Sect. II: Structure and function of the cardiovascular system
Sect. III: Diagnostic and therapeutic methods
Sect. IV: Electrophysiology
Sect. V: Pediatric cardiac intensive care
Sect. VI: Congenital cardiovascular malformations
Pt. A: Septal defects
Pt. B: Arterial abnormalities
V. II: Pt. C: Venous abnormalities
Pt. D: The right ventricle
Pt. E: Left ventricular inflow and outflow abnormalities
Pt. F: Abnormalities of the origin of the great arteries
Pt. G: Complex cardiac abnormalities
Sect. VII: Diseases of the endocardium, myocardium, and pericardium
Sect. VIII: Pulmonary vascular disease
Sect. IX: Unique issues regarding the young adult with congenital heart disease
Sect. X: Other special problems and issues.

Summary: Despite the importance of regaining social roles during recovery from mental illness, the intersection between motherhood and serious mental illness is often overlooked. This book aims to rectify that neglect. A series of introductory chapters describing current research and services available to mothers with serious mental illness are followed by personal accounts of clients reflecting on their parenting experiences. One goal of the book is to provide clinicians with information on this seldom addressed topic, which they can then use to help patients who are struggling with questions and barriers in their attempts to parent. The inclusion of personal accounts of mothers on issues such as stigma, fears, and discrimination in the context of parenting with a mental illness is intended to promote the message of mental illness recovery to a larger audience as well. Finally, it is hoped that this handbook will help inspire more research on mothers with mental illness and the creation of more services tailored to their needs.

Summary: Women are entering medical school in equal numbers as men, yet still face unique challenges in a profession where, overall, male physicians outnumber female physicians 3 to 1. Women in medicine also face decisions such as when to have a child during training and often struggle with work-life balance. This book features real stories and advice from mothers in medicine at all stages of training from medical student to practicing physician and addresses the topics that shape the lives, joys, and challenges of women in medicine today. The book is based on the best posts and wisdom shared on the Mothers in Medicine blog, which was established in 2008 by the editor and has published over 1500 posts and has over 4.8 million page views to date. The book is organized by themes that are unique to the physician-mother: career decisions, having children during training, navigating life challenges, practice issues, and work-life balance. Each chapter features an excerpt from the blog followed by an honest discussion of the key considerations, guidelines, and tips as related to each topic in the conversational, personal tone of the blog. The book concludes with a chapter that features the most popular questions posted on the Mothers in Medicine blog and a summary of the responses received from the community of readers. Mothers in Medicine: Career, Practice, and Life Lessons Learned is a valuable and contemporary resource for pre-medical students, medical students, residents, and physicians.

Contents:
Choosing Motherhood and Medicine: The First Questions.- Having and Raising Children During Physician Training: Medical School.- Having and Raising Children During Physician Training: Residency
Being a Mother in Medicine in Practice.- Choosing Where and How to Work
Balancing Work and Life.- Sharing the Humor in Being a Mother in Medicine.- Embracing the Mother in Medicine’s Village of Support.- Navigating Life Challenges as a Mother in Medicine.- Negotiating for the Job You Want.- Question and Answer: The Collective Wisdom of Mothers in Medicine.

Summary: This book illustrates the clinical interface between neurology and psychiatry by focusing on neuropsychiatric conditions characterised by alterations at the level of both motor function and behaviour. The neuropsychiatric approach to movement disorders and epilepsy is of key importance in clinically assessing and treating these common and often disabling conditions. While addressing the clinical challenges posed by the behavioural aspects of movement disorders and epilepsy, it invites readers on a journey through the evolving discipline of neuropsychiatry / behavioural neurology - both in the past and today.

Contents:
Neuropsychiatry and behavioural neurology
The neuropsychiatry of movement disorders
The neuropsychiatry of epilepsy
Conclusion: past, present and future.

Contents:
Section 1: Theories of motivation. Common and distinctive approaches to motivation in different disciplines / T. Strombach, S. Strang, S.Q. Park, P. Kenning
A benefit-cost framework of motivation for a specific activity / B. Studer, S. Knecht
Control feedback as the motivational force behind habitual behavior / O. Nafcha, E.T. Higgins, B. Eitam
Section 2: Assessing motivation. Quantifying motivation with effort-based decision-making paradigms in health and disease / T.T.-J. Chong, V. Bonnelle, M. Husain
Section 3: The neurobiology of motivation. Brain correlates of the intrinsic subjective cost of effort in sedentary volunteers / J. Bernacer, I. Martinez-Valbuena, M. Martinez, N. Pujol, E. Luis, D. Ramirez-Castillo, M.A. Pastor
To work or not to work: Neural representation of cost and benefit of instrumental action / N.B. Kroemer, C. Burrasch, L. Hellrung
Involvement of opioid signaling in food preference and motivation: Studies in laboratory animals / I. Morales, L. Font, P.J. Currie, R. Pastor
Exploring individual differences in task switching: Persistence and other personality traits related to anterior cingulate cortex function / A. Umemoto, C.B. Holroyd
Competition, testosterone, and adult neurobehavioral plasticity / A.B. Losecaat Vermeer, I. Riečanský, C. Eisenegger
Fatigue with up- vs downregulated brain arousal should not be confused / U. Hegerl, C. Ulke
Section 4: Targeting motivation: novel approaches to enhancing motivation, activity and learning in health and disease. Intrinsic motivation, curiosity, and learning: Theory and applications in educational technologies / P.-Y. Oudeyer, J. Gottlieb, M. Lopes
Applied economics: The use of monetary incentives to modulate behavior / S. Strang, S.Q. Park, T. Strombach, P. Kenning
Rewarding feedback promotes motor skill consolidation via striatal activity / M. Widmer, N. Ziegler, J. Held, A. Luft, K. Lutz
How motivation and reward learning modulate selective attention / A. Bourgeois, L. Chelazzi, P. Vuilleumier
Motivation and attention following hemispheric stroke / E. Olgiati, C. Russell, D. Soto, P. Malhotra
Increasing self-directed training in neurorehabilitation patients through competition / B. Studer, H. Van Dijk, R. Handermann, S. Knecht
The role of dopamine in the pathophysiology and treatment of apathy / T.T.-J. Chong, M. Husain
Changing health behavior motivation from I-must to I-want / S. Knecht, P. Kenning
Section 5: Conclusions. Motivation: What have we learned and what is still missing? / B. Studer, S. Knecht.

Contents:
1 Theories of Motor Development
2 Motor Assessment of the Developing Infant
3 Alberta Infant Motor Scale: Construction of a Motor Assessment Tool for the Developing Infant
4 Administration Guidelines
5 Prone Subscale
6 Supine Subscale
7 Sit Subscale
8 Stand Subscale
9 Clinical Uses of the Alberta Infant Motor Scale
10 Psychometric Properties of the AIMS
11 Norm-Referencing of the Alberta Infant Motor Scale
Appendix I Percentile Ranks
AIMS Score
Appendix II Percentile Ranks by Age Grouping
Appendix III Normative Data
Appendix IV Percentile Ranks
Index.

Summary: "This twelfth edition primarily updates the previous edition by adding more recent research and interpretations of the concepts and theoretical views associated with those concepts that were in the eleventh edition. Similar to the previous editions this new edition continues its two most distinctive features as an introductory motor learning and control textbook: its overall approach to the study of motor learning and control and the organization of the implementation of that approach. In every edition of this book, the overall approach has been the presentation of motor learning and control "concepts" to identify the common theme of each chapter. The concepts should be viewed as generalized statements and conclusions synthesized from collections of research findings. Following the concept statement is a description of a real-world application of the concept, which is then followed by discussions of specific topics and issues associated with the concept. An important part of these discussions are summaries of research evidence, on which we base our present knowledge of each topic and issue, as well as the implications of this knowledge for practitioners. The benefit of this organizational scheme is the presentation of motor learning and control as a set of principles and guidelines for practitioners, which are based on research evidence rather than on tradition or "how things have always been done"-- Provided by publisher

Contents:
Unit One. Introduction to motor skills and abilities
Unit Two. Introduction to motor control
Unit Three. Attention and memory
Unit Four. Introduction to motor skill learning
Unit Five. Instruction and augmented feedback
Unit Six. Practice conditions.

Contents:
Introduction to motor neuron disease
History of the recognition of motor neuron disease
Nomenclature & classification of motor neuron disease
Clinical anatomy, physiology and pathology of motor neuron disease
Clinical features of motor neuron disease
Frontotemporal dysfunction and dementia in amyotrophic lateral sclerosis
Laboratory tests for motor neuron disease
Biomarkers for motor neuron disease
Imaging in motor neuron disease
Diagnostic criteria for motor neuron disease
Differential diagnosis of motor neuron disease
Motor neuron disease progression
Epidemiology of amyotrophic lateral sclerosis
Genetics of amyotrophic lateral sclerosis and frontotemporal dementia
Genome-wide approaches to identify amyotrophic lateral sclerosis-associated genes
Pathology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
Convergence and divergence in amyotrophic lateral sclerosis syndrome: genetics, molecular pathways and molecular mechanisms:
Immunologic aspects of amyotrophic lateral sclerosis
Cyanobacteria, amyotrophic lateral sclerosis, and the BMAA hypothesis
Animal models of adult motor neuron disease
Multidisciplinary clinics and practice parameters and guidelines
Allied health and other providers
Respiratory assessment and management
Nutritional assessment and management
Communication assessment and management
Psychological and psychiatric assessment and management
Symptoms and management
Intimacy, sexuality and pregnancy
Quality of life
Caregiver issues
End of life care
Costs of amyotrophic lateral sclerosis care
Clinical trial designs in amyotrophic lateral sclerosis
Stem cell therapy for motor neuron disease.

Contents:
1. Fundamentals of being a sport surgeon
2. Motor learning principles for arthroscopic motor skill teaching
3. How to teach concepts of surgical skills and strategy of designing a programme
4. Setting up a curriculum
5. Defining essential skills
6. Arthroscopic skills training modalities
7. Simulators in surgical skills training
8. Aspects of a cource design
9. Establishing validation methods: measuring progress (measuring teaching effectiveness)- global rating scales
10. Certification of surgical skills
Conclusion.

Contents:
Approach to dysphagia / Gina R. Sam
Approach to nausea and vomiting / Aimee L. Lucas
Approach to abdominal pain / Jonathan Z. Potack
Approach to diarrhea / Bruce E. Sands
Approach to constipation / Mark A. Korsten, Hanumantha R. Ancha, and Miriam Kaminski
Approach to fecal incontinence / Sita S. Chokhavatia
Approach to gastrointestinal bleeding / Blair S. Lewis and Christina A. Tennyson
Approach to nutrition assessment / Laura Manning and Lauren K. Schwartz
Approach to the pregnant patient with GI disorders / Elana A. Maser
Gastroesophageal reflux disease / Lawrence B. Cohen
Barrett's esophagus / Sharmila Anandasabapathy
Eosinophilic esophagitis / Brijen J. Shah
Esophageal motility disorders / Barry W. Jaffin
Esophageal disorders related to medication, trauma, and infection / Stuart I. Finkel
Management of foreign bodies of the GI tract / James George
Functional dyspepsia / Sita S. Chokhavatia
Peptic ulcer disease / Neville D. Bamji and Ariel A. Benson
Helicobacter pylori treatment and eradication / Anthony A. Weiss
Gastroparesis / Eric S. Goldstein
GI complications of obesity surgery / Jonathan Z. Potack
Tumors of the foregut / Michelle Kang Kim
Short bowel syndrome and malnutrition / Lauren K. Schwartz and Benjamin L. Cohen
Bacterial overgrowth / Peter H. Rubin
Celiac disease / Ariel A. Benson and James Aisenberg
Infectious enteritis and colitis; bacterial food poisoning; intestinal protozoa and helminthic infestations / Jenny Sauk
Immunodeficiency and the GI tract / Saurabh Mehandru
GI stromal tumors / Peter E. Legnani
Neuroendocrine tumors / Richard R.P. Warner
Pancreatitis (acute, chronic, autoimmune) / Jeffrey R. Lewis and Yuki Young
Pancreatic cysts and tumors / Christopher J. DiMaio
Disorders of the biliary tract / Ron Palmon and Kalpesh K. Patel
GI complications of transplant / Vera Kandror Denmark
Vascular lesions of the GI tract / Jose Romeu
Irritable bowel syndrome / Charles D. Gerson
Crohn's disease / Joana Torres and Jean-Frédéric Colombel
Ulcerative colitis / Adam F. Steinlauf and Daniel H. Present
Complications of restorative proctocolectomy with ileal pouch-anal anastomosis / Joel J. Bauer and Stephen R. Gorfine
Radiation enterocolitis / Prashant Kedia and Adam Steinlauf
Clostridium difficile / Gerald Friedman
Ischemic disease of the small and large bowel / Ari Grinspan and Asher Kornbluth
Diverticular diseases of the colon / David B. Sachar
Adenocarcinoma of the large bowel and hereditary colon cancer syndromes / Steven H. Itzkowitz
Colonoscopic polypectomy / Jerome D. Waye
Surveillance for dysplasia in inflammatory bowel disease / Thomas A. Ullman
Diseases of the anus and rectum / Alexander J. Greenstein and Sergey Khaitov
Complications of GI endoscopy / James F. Marion.

Contents:
Introduction. DSM-5 / Evan Leibu, Michael B First
Research Domain Criteria (RDoC) / Tobias B Halene, Vilma Gabbay
Functional Neuroanatomy / James W Murrough, Amy R Glick, Nicholas S Stevens, Thomas P Naidich
Translational Neuroscience in Clinical Psychiatry / Ivan Chavarria-Siles, Emily Stern, Schahram Akbarian, Pamela Sklar, Eric J Nestler
Neuropsychological Assessment and Psychological Tests / Katherine E Burdick, Manuela Russo, Jane Martin
Clinical Use of Laboratory Tests, Brain Imaging, and Biomarkers / Carrie L Ernst, James W Murrough
Neuromodulation Treatments / Kyle AB Lapidus, Nigel I Kennedy, Wayne K Goodman, Charles H Kellner
General Principles of Psychotherapy / Asher B Simon, Michael Brus
Clinical Documentation / Amanda Focht, Gloria J Rodriguez, Brian Fuchs
Adult Disorders. Depressive Disorders / Hiwot Woldu, James W Murrough, Dan V Iosifescu
Bipolar Disorders / Le-Ben Wan, Joseph F Goldberg, Katherine E Burdick, Dan V Iosifescu
Anxiety Disorders / Marc S Lener, Dennis S Charney, Adriana Feder
Trauma- and Stressor-Related Disorders / Rachel Yehuda, Amy Lehrner, Laura C Pratchett
Obsessive-Compulsive and Related Disorders / Dorothy E Grice, Timothy Rice, Wayne K Goodman
Schizophrenia Spectrum and Other Psychotic Disorders / Rachel Moster, Larry J Siever, Sophia Frangou
Substance Use and Addictive Disorders / Allison K Ungar, Anna B Konova, Alkesh Patel, Rita Z Goldstein, Yasmin L Hurd
Personality Disorders / Antonia S New, M Mercedes Perez-Rodriguez, Jake Rosenberg
Psychiatric Presentations of Primary Medical Illness / Adam Karz, Madeleine Fersh, Akhil Shenoy, Kim Klipstein
Neuropsychiatric Illnesses / Silvana Riggio, Zorica Filipovic-Jewell, Devendra S Thakur
Somatic Symptom and Related Disorders, Including Illness Anxiety, Factitious, Malingering, and Conversion Disorders / Hansel Arroyo, Kim Klipstein, Carrie L Ernst, Jennifer Finkel
Sexual Dysfunctions, Gender Dysphoria, and Paraphilic Disorders / Stephen Snyder, William Byne, Sara Lozyniak
Eating Disorders / Thomas B Hildebrandt, Sharon M Batista, Matthew Shear, Yadira Alonso
Sleep-Wake Disorders / Akhil Shenoy, Rachel Fischer, Amir Garakani
Child/Adolescent Disorders. Assessment of Child Development / Suzanne Garfinkle, Mary M LaLonde, John O'Brien
Autism Spectrum Disorder / Benjamin N Angarita, Alexander Kolevzon
Intellectual Developmental Disorders in Children and into Adulthood / Jesse L Costales, Asher B Simon, Katharine A Stratigos
Child and Adolescent Anxiety Disorders / Thomas J DePrima, Vilma Gabbay
Attention-Deficit/Hyperactivity Disorder / Jeffrey H Newcorn, Laura Powers, Stacy McAllister
Child and Adolescent Disruptive, Impulse Control, and 'Across Cultures / Daniella Loh, Olanrewaju Dokun, Sharon M Batista
Complementary and Alternative Medicine in Psychiatry / Ellen Vora, Amy Aloysi, Rachel Zhuk
Models for Delivery of Care / Sabina Lim, Joseph M Cerimele.

Summary: This book is written for general readers with an interest in science, and offers the tools and ideas for understanding how climate change will affect mountains of the American West. A major goal of the book is to provide material that will not become quickly outdated, and it does so by conveying its topics through constants in ecological science that will remain unchanged and scientifically sound. The book is timely in its potential to be a long-term contribution, and is designed to inform the public about climate change in mountains accessibly and intelligibly. The major themes of the book include: 1) mountains of the American West as natural experiments that can distinguish the effects of climate change because they have been relatively free from human-caused changes, 2) mountains as regions with unique sensitivities that may change more rapidly than the Earth as a whole and foreshadow the nature and magnitude of change elsewhere, and 3) different interacting components of ecosystems in the face of a changing climate, including forest growth and mortality, ecological disturbance, and mountain hydrology. Readers will learn how these changes and interactions in mountains illuminate the complexity of ecological changes in other contexts around the world.

Contents:
Intro
Preface
Acknowledgments
Contents
Chapter 1: Introduction: What Persists, What Changes
Why These Mountains?
Where Are We Going?
What Doesn't Change in What Changes
Ice or Water, Snow or Rain
Evolution
Movement
Interactions
Concepts and Terms You Should Know
Variable
Parameter
Correlation
Feedback
Gradient
Succession
Disturbance
Treeline
Rain Shadow
Climatic Envelope
Connectivity
Limiting Factor
Scale
Uncertainty
Stationarity
Detection and Attribution
Chapter 2: The Mountains How Will It Affect the Western Mountains?
The Cascade Range and the Pacific Coast Ranges (to the Klamath and Trinity Mountains)
The Northern Rocky Mountains
The Sierra Nevada
The Pacific Coast Ranges (South of the Klamath and Trinity Mountains)
The Southern and Central Rocky Mountains
The Sky Islands and the Basin Ranges
Chapter 4: Water Towers of the West
The Magic Line: Snow or Rain, Frozen or Melted
Glaciers: A Pure Signal of a Warming Climate?
Changes in Mountain Hydrology
Eco-hydrological Models: How Can We Use Them for Climate-Change Projections? The Cascade Range: America's Alps
The Sierra Nevada: The Range of Light
The Rocky Mountains: The Continental Divide
The Pacific Coast Ranges
The Olympic Mountains
Siskiyou-Klamath-Trinity Mountains
Transverse and Peninsular Ranges
The Basin Ranges
The Sky Islands
Western Mountain Vulnerabilities
Vegetation
Glaciers, Snowpack, and Hydrology
Biogeochemistry
Wildlife
Wilderness Character
Chapter 3: It's Getting Warm Down Here
What Do We Know About Climate Change?
How Do We Know It?
How Well Do We Know It? The Pacific Coast Ranges (South of the Klamath and Trinity Mountains)
The Southern and Central Rocky Mountains
The Sky Islands and the Basin Ranges
Chapter 6: Ecological Disturbance
What Is a Disturbance?
Fire Regimes in the Western Mountains
Gradients of Fire Frequency and Severity at Different Scales
Smoke and Regional Haze
Wildfire and Climate: How We Know What We Know
Sediment Charcoal
Fire-Scarred Trees and Stand Reconstructions
Native American Burning: Confounding the Inference?
The Observational Record What Do We Expect for the Western Mountains?
Chapter 5: Trees, Forests, and Carbon
Forest Biology and Ecology: What Persists and What Changes
Forest Succession
Dispersal: Keeping Up?
Carbon: Source or Sink?
Feedbacks to Climate Change
Forests on the Brink? An Example of Detection and Attribution
Forest Models: How Can We Use Them for Climate-Change Projections?
What Do We Expect for the Western Mountains?
The Cascade Range and the Pacific Coast Ranges (to the Klamath and Trinity Mountains)
The Northern Rocky Mountains
The Sierra Nevada

Contents:
Modeling cancer using genetically engineered mice / Patricia Stiedl ... [and 4 others]
Lung adenocarcinomas : comparison between mice and men / Helmut H. Popper
Mouse models of breast cancer / Kazuhito Sakamoto, Jeffrey W. Schmidt, and Kay-Uwe Wagner
Genetically engineered mouse models to study prostate cancer / Elspeth A. Brzezinska ... [and 3 others]
Practical use of advanced mouse models for lung cancer / Roghaiyeh Safari and Ralph Meuwissen
Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations / Johan H. van Es and Hans Clevers
Induction of colorectal cancer in mice and histomorphometric evaluation of tumors / Ilija Crncec ... [and 3 others]
Mouse models of liver cancer / Jorge Matias Caviglia and Robert F. Schwabe
Current methods in mouse models of pancreatic cancer / Pawel K. Mazur ... [and 3 others]
Mouse models of nonmelanoma skin cancer / Nicole Amberg ... [and 5 others]
Clinicopathological characterization of mouse models of melanoma / Blake Ferguson, H. Peter Soyer, and Graeme J. Walker
Modeling BCR/ABL-driven malignancies in the mouse / Christine Schneckenleithner, Andrea Hoelbl-Kovacic, and Veronika Sexl
Methods to generate genetically engineered mouse models of soft tissue sarcoma / Rebecca D. Dodd ... [and 5 others]
Characterization of mouse model-derived osteosarcoma (OS) cells in vitro and in vivo / Özge Uluçkan, Latifa Bakiri, and Erwin F. Wagner
Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma / Claudia A. Benavente and Michael A. Dyer
Tumor imaging technologies in mouse models / Michael Bouvet and Robert M. Hoffman
Tumor angiogenesis : methods to analyze tumor vasculature and vessel normalization in mouse models of cancer / Federica Maione and Enrico Giraudo
Transplantable mouse tumor models of breast cancer metastasis / Rumela Chakrabarti and Yibin Kang
Methods to study primary tumor cells and residual tumor cells in mouse models of oncogene dependence / Caroline Botta ... [and 3 others]
Generation of transgenic mouse model using PTTG as an oncogene / Sham S. Kakar and Cohin Kakar
Modeling the study of DNA damage responses in mice / Julia Specks ... [and 3 others]
Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice / Eva Bauer ... [and 3 others].

Contents:
Part I Re-stenosis Models After Angioplasty
Wire-mediated endovascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia
Cuff-induced neointima formation in mouse models
Ligation of the Mouse Common Carotid Artery
Photochemically Induced Endothelial Injury
Part II Thrombosis and Hemostasis Models
Murine Models of Thrombosis and Hemostasis
Part III Transplant-Associated Atherosclerosis
Murine Heart Transplantation and Graft Arterial Disease
Murine Models of Vein Grafting
Part IV Hyperlipidemia-Induced Atherosclerosis
Mouse Models of Atherosclerosis
Part V Aneurysm in the Aorta
Angiotensin II-induced Aortic Aneurysms in Mice
Mouse model of abdominal aortic aneurysm induced by CaCl2
Mouse models of aortic aneurysm (tentative)
Part VI Intracranial Aneurysm Models
Technical aspects of mouse intracranial aneurysm model
Experimental model of cerebral aneurysms in ovariectomized rats
Part VII Vascular Disease in Cerebral Arteries
A model of stroke and vascular injury in the brain
Part VIII Kawasaki Disease
Analysis of Kawasaki disease using a mouse model, CAWS vasculitis in DBA/2 mice, induced with a water-soluble extracellular polysaccharide fraction obtained from Candida albicans.

Contents:
In situ Hybridization Methods for Mouse Whole Mounts and Tissue Sections with and Without Additional [beta]-galactosidase Staining
Two Color In Situ Hybridization of Whole-Mount Mouse Embryos
Detection and Monitoring of MicroRNA Expression in Developing Mouse Brain and Fixed Brain Cryosections
Laser Capture Microdissection of Embryonic Cells and Preparation of RNA for Microarray Assays
EMAGE: Electronic Mouse Atlas of Gene Expression
Real-time PCR Quantification of gene Expression in Embryonic Mouse Tissue
Identifying Essential Genes in Mouse Development Via an ENU-based Forward Genetic Approach
Generation of Mouse Embryos with Small Hairpin RNA-mediated Knockdown of Gene Expression
Generation of Tissue Organoids by Compaction Reaggregation
Ultra-Rapid Vitrification of Mouse Oocytes and Embryos
Mammalian Preimplantation Embryo Culture
Serum-Free Culture of Mid-Gestation Mouse Embryos: A Tool for the Study of Endoderm-Derived Organs
Genetically Encoded Probes Provide a Window On Embryonic Arrhythmia
Microscopic Computed Tomography-based Skeletal Phenotyping for Genetic Model Organisms
Gene Transfer Techniques in Whole Embryo Cultured Post-Implantation Mouse Embryos
Segmentation and Quantitative Analysis of Individual Cells in Developmental Tissues
Protein/Peptide Transduction in Metanephric Explant Culture
Direction of Cells Programmed to Die in Mouse Embroys
Microscopic Computed Tomography-based ?Virtual Histology of Embryos
Collection and Preparation of Rodent Embryonic Samples for Transcriptome Study
The Latest Improvements in the Mouse Sperm Preservation
Analyzing Gene Function in Whole Mouse Embryo and Fetal Organ in vitro
Using the Textpresso Site Specific Recombinases Web Server to Identify ?Cre Expressing Mouse Strains and Floxed Alleles
Live Imaging Mouse Embryonic Development: Seeing is Believing and Revealing
Genetic Cell Ablation
Essentials of Recombinase-based Genetic Fate Mapping in Mice.

Summary: Some geographic regions around the globe that are rich in terms of modern agriculture technologies, face a dilemma when it comes to storing excess produce, such as grains and even seasonal fruits and vegetable. They are often forced to destroy the surplus agricultural products due to the constraints of poor logistic systems, food warehouses and micro-economy system management. In contrast, millions of people in extreme rural areas are suffering from hunger and poverty. This book offers suggestions to resolve the problems of food security and poverty in rural areas and ensure minimum social justice so that those in rural areas have regular access to food and shelter. It also discusses how to develop sustainable foundations in extreme rural locations using indigenous resources to tackle issues like hunger, malnutrition, and chronic health problems.

Contents:
Intro; Preface; Contents; About the Authors; Abbreviations;
1: Move Towards Zero Hunger; 1.1 Envisioning Zero Hunger; 1.1.1 Genesis of Zero Hunger Concepts; 1.1.2 Strategic Plan for Food Security and Zero Hunger; 1.1.3 Social Inclusion for Zero Hunger; 1.1.4 Resilience-Building Approach; 1.1.4.1 Government and Governance; 1.1.4.2 Governance and Agriculture; 1.1.4.3 Governance and Food Security; 1.1.4.4 Entry Points for Food Security Initiatives; 1.1.4.5 Food Security Information System; 1.1.4.5.1 Resilience Social Habitat Approach; 1.1.5 What Causes Hunger?; 1.1.5.1 Poverty 1.1.5.2 Job Instability1.1.5.3 Food Shortages and Waste; 1.1.5.4 Food Price Volatility and Hunger; 1.1.5.5 Social Discrimination and Hunger; 1.1.6 Pillars of Food Security; 1.1.6.1 Availability; 1.1.6.2 Access; 1.1.6.3 Use and Utilisation; 1.1.6.4 Stability; 1.1.7 Challenges to Food Security; 1.1.7.1 Water Scarcity; 1.1.7.2 Land Degradation; 1.1.7.3 Climate Changes; 1.1.7.4 Agriculture Diseases; 1.1.7.5 Food Versus Biofuel; 1.1.7.6 Food Waste; References;
2: Water, Energy and Food Security: Pillars for Zero Hunger; 2.1 Introduction; 2.1.1 Water Security for Food 2.1.1.1 Water Scarcity2.1.1.2 Supply and Demand of Freshwater; 2.1.1.3 Water Availability in Rural Areas; 2.1.1.3.1 Groundwater; 2.1.1.3.2 Harnessing Seawater for Rural Livelihood; 2.1.1.3.3 Glaciers as Water Source; 2.1.1.3.4 Rainwater Harvesting; 2.1.2 Energy Security for Food; 2.1.2.1 What Is Energy Security?; 2.1.2.2 Access to Energy; 2.1.2.2.1 Access to Electricity; 2.1.2.2.2 Access to Natural Gas; 2.1.2.2.3 Access to Renewable Energy; 2.1.2.3 Solutions to Energy Crisis in Rural Areas; 2.1.2.3.1 Move for Renewable Resources; 2.1.2.3.2 Buy Energy-Efficient Products 2.1.2.3.3 Lighting Controls2.1.2.3.4 Grid Access; 2.1.2.3.5 Energy Simulation; 2.1.2.3.6 Energy Audit; 2.1.2.3.7 Common Stand on Climate Change; 2.1.2.3.8 Biowaste Recycling for Methanol Production; 2.1.2.3.9 Use of "Flex-Fuel" in Automobiles; 2.1.3 Food Security; 2.1.3.1 Factors for Food Availability; 2.1.3.1.1 Availability; 2.1.3.1.2 Access; 2.1.3.1.3 Use and Utilisation; 2.1.3.1.4 Stability; 2.1.3.2 International Organisation for Food Security; References;
3: Paradigm for Zero Hunger; 3.1 International Development; 3.1.1 Modernisation Theory; 3.1.2 Dependency Theory 3.1.3 World-Systems Theory3.1.4 Neoliberalism; 3.1.5 Good Governance; 3.1.6 Capability Approach; 3.2 Global Goals for Eradication of Hunger and Poverty; 3.2.1 Millennium Development Goals (MDGs); 3.2.2 Sustainable Development Goals; 3.3 Global Food System; 3.3.1 Conventional Food System; 3.3.1.1 Conceptual Development of Food System; 3.3.1.2 Conventional Farming; 3.3.1.3 Community Food System; 3.3.2 Alternative Food System; 3.3.2.1 Local Food System; 3.3.2.2 Organic Food System; 3.3.3 Cooperatives in Food System; 3.3.4 Fair Trade; 3.4 Food System Supply Chain Management

Summary: This book logically and systematically reviews the major movement disorder emergencies. It instructs the reader on how to recognize and manage these problems. This updated new edition of Movement Disorder Emergencies consists of five comprehensive sections. It begins with chapters that relay the various practical approaches one can administer when treating a patient with a movement disorder emergency. Section two then delves into specific hyperacute movement disorder emergencies such as acute parkinsonism, serotonin syndrome, and malignant catatonia. Following this, section three examines various acute movement disorder emergencies, including tic emergencies and Sydenham’s chorea. Sections four and five explore issues that can occur during treatment, such as pitfalls in diagnosis and risks in the clinic. Written by prominent neurologists from around the world, Movement Disorder Emergencies, 3rd edition is a practical reference that achieves excellence in diagnosis and management of movement disorder emergencies.

Summary: This book covers recent developments and possible pitfalls in the diagnosis of genetic movement disorders and related conditions. It is divided into three sections: technical and scientific aspects; clinical aspects with guidance towards work-up; and ethical and legal aspects of genetic testing in a clinical and research setting. The first section includes chapters on genetic analysis and counselling with critical discussion of potential problems when interpreting the results. Clinical chapters summarize genetic forms of movement disorders including parkinsonism, tics and dystonia with algorithms for hands-on daily practice. Related conditions such as RLS, ataxias and dementias are also covered. Finally, chapters on ethical and legal aspects of genetic testing are included. Movement Disorder Genetics is aimed at clinicians and scientists working in the field of movement disorders and related conditions. .

Contents:
Genetics of Mendelian Forms of Parkinson?s Disease
Genetics of Parkinson?s Disease
Genetics of Atypical Parkinsonism
Genetics of Dementia with Lewy Bodies
Genetics of Frontotemporal Dementia
Genetics of Primary Tremor Disorders
Genetics of Dystonia
Genetic Choreas
Genetics of Tourette Syndrome
Genetics of Paroxysmal Dyskinesia
Genetics of Dominant Ataxias
Genetics of Recessive Ataxias
Genetics of NBIA Disorders
Genetics of Metal Disorders (Excluding NBIA)
Genetics of Restless Legs Syndrome (RLS)
Genetics of Hereditary Spastic Paraplegias (HSP)
Genetics of ALS
Genetics of Mitochondrial Disease with Focus on Movement Disorders
Introduction to Genetics and Genetic Counseling for Clinicians
Genetic Testing
An Industrial Perspective
Direct-to-Consumer DNA Genetic and Genomic Testing
Current Ethical Issues Related to the Implementation of Whole Exome and Whole Genome Sequencing
Implications for Health and Life Insurances and Other Legal Aspects of Genetic Testing.

Contents:
Section I: Scientific foundations. Taxonomy and clinical features of movement disorders
Modeling disorders of movement
New transgenic technologies
Assessment of movement disorders in rodents
Drosophila
Use of Caenorhabditis elegans to model human movement disorders
Zebrafish
Techniques for motor assessment in rodents
Induced pluripotent stem cells (iPSCs) to study and treat movement disorders
Neurophysiologic assessment of movement disorders in humans
Neurophysiological and optogenetic assessment of brain networks involved in motor control
Functional imaging to study movement disorders
Human and nonhuman primate neurophysiology to understand the pathophysiology of movement disorders
Section II: Parkinson disease. The phenotypic spectrum of Parkinson disease
genetics and molecular biology of Parkinson disease
Genotype-phenotype correlations in Parkinson Disease
From man to mouse: the MPTP model of Parkinson disease
Rodent models of autosomal dominant Parkinson disease
Rodent models of autosomal recessive Parkinson disease
Drosophila models of Parkinson Disease
Primate models of complications related to Parkinson disease treatment
Rodent models of treatment-related complications in Parkinson disease
Methods and models of the nonmotor symptoms of Parkinson disease
Section III: Dystonia. Dystonia: phenotypes and genetics
Murine models of caytaxin deficiency
Animal models of focal dystonia
Mouse models of dystonia
Rodent models of autosomal dominant primary dystonia
Modeling dystonia-parkinsonism
Section IV: Huntington disease. Genetics of Huntington disease (HD), HD-like disorders, and other choreiform disorders
Murine models of HD
Use of genetically engineered mice to study the biology of huntingtin
Modeling Huntington disease in yeast and invertebrates
HDL2 mouse
Analysis of nonmotor features in murine models of Huntington Disease
Section V: Tremor. Essential tremor
Use of the harmaline and [alpha]1 knockout models to identify molecular targets for essential tremor
Physiological and behavioral assessment of tremor in rodents
Mouse models of the fragile X tremor/ataxia syndrome (FXTAS) and the fragile X premutation
Section VI: Myoclonus. Myoclonus: Classification, Clinical Features, and Genetics
Mouse model of Unverricht-Lundborg disease
Post-hypoxic myoclonus in rodents
Generating mouse models of mitochondrial disease
Secion VII: Tics. Tics and Tourette Syndrome: Phenomenology
Genetics of Tourette syndrome
Neural circuit abnormalities in Tourette syndrome
Animal models of Tourette Syndrome and obsessive-compulsive disorder
Section VIII: Paroxysmal movement disorders. Paroxysmal Movement Disorders: Clinical and Genetic Features
Mouse models of PNKD
Glut1 deficiency (G1D)
Animal models of episodic ataxia type 1 (EA1)
Mouse models of episodic ataxia type 2. Section IX: Tauopathies. Tauopathies: Classification, Clinical Features, and Genetics
Drosophila models of tauopathy
Tauopathy mouse models
Tau protein: biology and pathobiology
Section X: Other Parkinsonian syndromes: NBIA, MSA, PD + spasticity, PD + dystonia. Clinical Phenomenology and genetics of other parkinsonian syndromes associated with either dystonia or spasticity
Animal models of multiple-system atrophy
Modeling PKAN in mice and flies
Mouse models of FA2H deficiency
Mouse models of neuroaxonal dystrophy caused by PLA2G6 gene mutations
Section XI: Ataxias. Genetics and Clinical Features of Inherited Ataxias
Animal models of spinocerebellar ataxia type 1
Mouse models of SCA3 and other polyglutamine repeat ataxias
animal models of Friedreich ataxia
Ataxia-telangiectasia and the biology of ataxia-telangiectasia mutated (ATM)
Autosomal recessive ataxias due to defects in DNA repair
Caenorhabditis elegans models to study the molecular biology of ataxias
Section XII: Hereditary spastic paraplegia. Hereditary Spastic Paraplegias: Genetics and Clinical Features
Mouse models of autosomal dominant spastic paraplegia
Murine models of autosomal recessive hereditary spastic paraplegia
Modeling hereditary spastic paraplegia (HSP) in zebrafish
Drosophila models of hereditary spastic paraplegia
Caenorhabditis elegans models of hereditary spastic paraplegia
Use of arabidopsis to model hereditary spastic paraplegia and other movement disorders
Section XIII: Restless legs syndrome. Clinical Phenotype and Genetics of Restless Legs Syndrome
Combined D3 receptor/iron-deficient mouse model
Use of Drosophila to study restless legs syndrome
The A11 lesion/iron deprivation animal model of restless legs syndrome
Btbd9 knockout mice as a model of restless legs syndrome.

Summary: Inherited metabolic movement disorders are a significant and rapidly evolving field of study, linking two subspecialty areas of childhood-onset movement disorders and inborn errors of metabolism. Increasing the chance of early recognition of inherited metabolic movement disorders can have significant therapeutic implications for patients. Containing information on new disorders of post-translational modification and autophagy and their identification and treatment, there is thorough coverage of disorders of amino acids, energy metabolism, and lysosomal storage, amongst others. This key resource explores future directions in the field including next-generation genetic sequencing and novel therapeutic approaches such as deep brain stimulation. Supplementary videos are available on Cambridge Core, accessible via the code printed inside the cover. This essential text bridges the gap in communication between experts in genetic-metabolic medicine and movement disorder neurology. With an emphasis on treatable conditions that should not be missed, this volume guides you through various disorders from a clinical, biochemical and genetic perspective.

Contents:
Basal ganglia anatomy, biochemistry, and physiology
Cerebellar anatomy, biochemistry, physiology, and plasticity
Classification of movement disorders
Diagnostic evaluation of children with movement disorders
Motor assessments
Transient and developmental movement disorders in children
Tics and tourette syndrome
Motor stereotypies
Paroxysmal dyskinesias
Chorea, athetosis, and ballism
Dystonia
Myoclonus
Tremor
Ataxia
Parkinsonism
Hereditary spastic paraplegia
Inherited metabolic disorders with associated movement abnormalities
Movement disorders in autoimmune diseases
Movements that occur in sleep
Cerebral palsy
Movement disorders and neuropsychiatric conditions
Drug-induced movement disorders in children
Functional (psychogenic) movement disorders
Appendixes. Drug appendix
Search strategy for genetic movement disorders
Video atlas.

Summary: "Movement Disorders in Childhood, Third Edition provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. In this new edition, each chapter has been fully revised to include all of the latest scientific and therapeutic advances. Updates include new insights in motor development, control, goal-directed and habitual behaviors, classifications of movements and their complex and integrated circuitry. The authors also discuss developments in pathophysiologic mechanisms, immunology and metabolic disorders. New chapters include coverage of genetics of movement disorders and movement disorders in psychiatric conditions. Appendices include an updated and revised drug index and genetic search strategy. An updated Companion website hosts selected educational videos to help diagnose movement disorders" -- publisher's description.

Summary: "This book focuses on extrapyramidal signs and symptoms of all types of dementia, and addresses the issue of the artificial boundary between dementias and Parkinsonism, which represent the two most common symptoms found in degenerative central nervous system diseases. In Movement Disorders in Dementias, movement disorder specialists from around the world write on topics generally restricted to dementia experts. Important motor issues related to either medication in demented patients (drug-induced movement disorders) or manifestations common to all forms of dementia, regardless of underlying cause (gait disorders, falls, fear of falling), is followed by analysis of the relationship between motor and cognitive symptoms, from their common pathogenesis to specific medical treatments. Movement Disorders in Dementias is aimed at general neurologists, dementia specialists, movement disorders specialists, neuropsychologists and geriatricians."--Publisher's website.

Summary: This book discusses the diagnosis and therapy for movement disorders of the upper extremities in children caused by brachial plexus injuries, peripheral nerve lesions or spasticity. The diagnostic procedures are presented from the perspective of pediatricians and surgeons. In addition to detailed descriptions of primary reconstructive and secondary surgical procedures, it also presents essentials of non operative treatment, such as physiotherapy, occupational therapy and orthopedic technologies. The book is rounded out with information on the management of these patients and their parents. Written by experienced clinicians, it offers valuable reading for plastic surgeons, pediatricians and surgeons who are interested in this topic.

Contents:
Part 1. Introduction
1. Introduction
2. History of Reconstructive Operations
3. Obstetric risk factors
Part 2. Diagnostics
4. Diagnostics and therapy planning from the perspective of the neuropaediatrician
5. Surgical diagnostic and measurement procedures
6. Objective acquisition of pathological movement patterns of the upper extremity: muscular coordination and movement analysis
7. "Invasive" diagnostic procedures: Electromyography, Neurography and Evoked Potentials
8. Central neural plasticity
Part 3. Conservative Treatment Methods
9. Physiotherapy
10. Occupational therapy for children and adolescents
11. Orthopaedic Technology
12. Botulinum Toxin
13. Self-concept
14. Inclusion
Part 4. Primarily reconstructive interventions
15. Reconstruction of traumatized nerves
16. Neuroorthopaedic management of congenital joint stiffness and muscle spasticity
17. Neurosurgical Options
18. Rare clinical features
19. Anaesthesia in infants and young children with birth traumatic plexus lesion
Part 5. Secondary interventions
20. Principles of orthopaedic correction
21. secondary reconstructive surgery
22. Non neural microsurgery in children
23. Secondary Microsurgery
Part 6. Follow-up Treatment
24. Specific post-operative treatment
25. Research on peripheral nerves and muscles
Part 7. The non-medical concern
26. Three testimonials on obstetric brachial plexus palsy
27. At home and at school
28. Professional life and sports
29. Legal Benefits for the severely disabled - the process for filing an eligibility claim with the pension and benefits office
Part 8. Forensic and legal issues
30. Legal Issues and Forensic Problems in Obstetrical Brachial Plexus Paresis
31. The role of the reconstructive surgeon in medico-legal practice.

Summary: This book presents a comprehensive, practical approach to the evaluation of movement disorders using phenomenological basic principles, new discoveries in phenomenological research, and core values of outpatient neurology. Movement Disorders Phenomenology begins with an overview of phenomenology and common approaches to movement disorder patients. Subsequent chapters then accurately and concisely relay information on major hypokinetic disorders such as atypical Parkinsonism, idiopathic Parkinson's disease, cortical myoclonus, and complex motor tics. Expertly written text is further supplemented by patient vignettes at the beginning of select chapter that focus the reader's attention and highlight the urgency of the problem. These high quality videos aid in the astute clinical diagnosis of many movement disorders that are still largely dependent on visual pattern recognition in the clinic. The book closes with a timely discussion on the role of genetics in movement disorders. Written for the practicing physician, Movement Disorders Phenomenology is an indispensable reference for neurology residents, general neurologists, movement disorders fellows and clinicians, and to any clinician who encounters and evaluates patients in the outpatient arena.

Contents:
Chapter 1. What Is Phenomenology and Why Should We Care?
Chapter 2. The Approach to the Movement Disorders Patient
Chapter 3. Typical Parkinson's Disease Phenomenology
Chapter 4. Phenomenology of Atypical Parkinsonism
Chapter 5. Phenomenology of Myoclonus
Chapter 6. Phenomenology of Tics
Chapter 7. Phenomenology of Chorea
Chapter 8. Phenomenology of Tremor
Chapter 9. Phenomenology of Dystonia
Chapter 10. Phenomenology of Ataxia
Chapter 11. The Voice in Movement Disorders
Chapter 12. "The Eyes Have It"
Saccades and Fixation Defects in Movement Disorders
Chapter 13. Phenomenology of Gait and Balance
Chapter 14. Unusual Phenomenologies
Chapter 15. Movement Disorders Emergencies
Chapter 16. Very Unusual Phenomenologies
Chapter 17. Imaging in Movement Disorder Phenomenology
Chapter 18. Genetics in Movement Disorders Phenomenology.