BookGregory A. Hosler, Kathleen M. Murphy.
Summary: "This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers -- clinicians, pathologists, laboratorians, and other inquisitive minds -- independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing "excise and pray" approaches with personalized medicine."--Publisher's website.
Contents:
1. Introduction
2. Basics of Nucleic Acids and Molecular Biology
3. Molecular Methods
4. Melanoma. Part I. Risk Assessment, Diagnosis, and Prognosis: Using Molecular Tools to Diagnose Melanoma, Predict Its Behavior, and Evaluate for Inheritable Forms
5. Melanoma. Part II. Personalized Medicine: Using Molecular Tools to Guide Targeted Therapy
6. Leukemia and Lymphoma. Part I. Mycosis Fungoides and Sézary Syndrome: Using Molecular Tools to Aid in the Diagnosis, Staging, and Therapy for Mycosis Fungoides and Sézary Syndrome
7. Leukemia and Lymphoma. Part II: Primary Cutaneous B-Cell Lymphoma and Other Non-MF/SS HematopoieticTumors
8. Tumors of the Soft Tissue: Using Molecular Tools to Aid in the Diagnosis of Soft Tissue Tumors and the Management of the Sarcoma Patient
9. Genodermatoses. Part I: Muir-Torre Syndrome
10. Genodermatoses. Part II: Other Hereditary Dermatologic Disease
11. Infectious Disease Testing
12. Emerging Molecular Applications and Summary.