Bookedited by Danny R. Welch and Paul B. Fisher.
Contents:
Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here
1. Introduction
2. Preclinical In Vitro and In Vivo Models of Metastasis
2.1. In Vitro Models
2.2. In Vivo Models
3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level)
3.1. Lab Tests/Histopathology
3.2. Noninvasive Blood Tests
3.3. Small Animal Imaging
3.4. Molecular-Genetic Imaging (Promoter-Based Protocols)
3.5. Circulating Tumor Cells
4. Approaches Used to Detect Metastatic Lesions (on a Clinical Level)
4.1. Biomarkers for Metastasis
4.2. Imaging Procedures
4.3. Circulating Tumor Cells
5. Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics)
6. Challenges Faced in Detecting Metastatic Cells
7. Conclusions and Future Directions
Acknowledgments
References
Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment
1. Introduction
2. Models to Study Tumor Cell Dormancy
3. Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy
4. Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment
5. Endosteal and Perivascular Niches Support Cancer Cell Dormancy
6. Reactivation from Dormancy
7. The Immune System and Dormancy
8. Summary and Outlook
References
Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches
1. Introduction
2. Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations
2.1. Epidemiological Analysis
2.2. Genetic Analysis Human Cohorts
3. Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis
3.1. Breast Cancer
3.2. Prostate Cancer
3.3. Melanoma
4. Conclusions
Acknowledgments
References
Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic ...
Concluding Thoughts
Acknowledgments
References
Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy
1. Introduction
2. Key Players
2.1. Monocytes
2.2. Macrophages
2.3. Neutrophils
2.4. T Lymphocytes
2.5. Natural Killer Cells
3. Invasion and Intravasation
3.1. Macrophages
3.2. Neutrophils
3.3. T Lymphocytes
4. Survival and Extravasation
4.1. Monocytes
4.2. Neutrophils
4.3. T Lymphocytes
4.4. NK Cells
5. Ectopic Growth
5.1. Macrophages
5.2. Neutrophils
5.3. T Lymphocytes
5.4. NK Cells
6. Therapeutic Implications
Acknowledgments
References
Chapter Six: MicroRNA and Metastasis
1. MicroRNAs
1.1. Noncoding RNAs and the Discovery of MicroRNAs
1.2. miRNA Biogenesis and Mechanisms of Action
1.3. miRNA Functions
2. miRNAs in Cancer ...