Bookedited by Lynne M. Coluccio.
Summary: Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact. Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.
Contents:
Introduction
Myosin Structure
Cargo Binding by Unconventional Myosins
Cryo-EM of Actin-Myosin Structures
Small Molecule Effectors of Myosin Function
Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction
High-Speed Atomic Force Microscopy to Study Myosin Motility
How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches
How Actin Tracks Affect Myosin Motors
Myosins in the Nucleus
Myosins in Cytokinesis
Myosins and Disease
Myosins and Hearing
The Actomyosin Systems in Apicomplexa
Approaches to Identify and Characterise MYO6-Cargo Interactions
Class IX Myosins: Motorized RhoGAP Signaling Molecules
Myosin X
Myosin XVI
Myosin XVIII
Myosin XIX.