BookEric J. Nestler, MD, PhD, Nash Family Professor and Chair of Neuroscience, Director,
... Show More Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, Steven E. Hyman, MD, Harvard University Distinguished Service Professor, Professor of Stem Cell and Regenerative Biology, Director, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, David M. Holtzman, MD, Andrew B. and Gretchen P. Jones Professor, Chair, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, Robert C. Malenka, MD, PhD, Pritzker Professor of Psychiatry, Deputy Director, Stanford Neurosciences Institute, Stanford University, Palo Alto, California.
Summary: Reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others.
Contents:
Basic principles of neuropharmacology
Cellular basis of communication
Synaptic transmission
Signal transduction in the brain
Excitatory and inhibitory amino acids
Widely projecting systems: monoamines, acetylcholine, and orexin
Neuropeptides
Atypical neurotransmitters
Autonomic nervous system
Neural and neuroendocrine control of the internal milieu
Pain
Neuroinflammation
Sleep and arousal
Higher cognitive function and behavioral control
Mood and emotion
Reinforcement and addictive disorders
Schizophrenia and bipolar disorder
Neurodegeneration
Seizure disorders
Stroke and migraine.