BookDayong Wang.
Summary: This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.
Contents:
Intro; Preface; Contents;
Chapter 1: Molecular Basis for Oxidative Stress Induced by Environmental Toxicants in Nematodes; 1.1 Introduction; 1.2 Evidence for the Direct Association of Oxidative Stress with Toxicity of Environmental Toxicants; 1.2.1 Induction of Oxidative Stress in Targeted Organs of Environmental Toxicants; 1.2.2 Pharmacological Evidence for the Association of Oxidative Stress and Toxicity Formation of Environmental Toxicants; 1.2.3 Association of Induction of Oxidative Stress in Intestine and Toxicity Formation in Other Targeted Organs 1.3 Molecular Machinery for the Activation of Oxidative Stress in Nematodes1.3.1 Role of GAS-1 in the Activation of Oxidative Stress; 1.3.2 Role of MEV-1 in the Activation of Oxidative Stress; 1.3.3 Role of ISP-1 in the Activation of Oxidative Stress; 1.3.4 Role of CLK-1 in the Activation of Oxidative Stress; 1.3.4.1 Mitochondrial CLK-1; 1.3.4.2 Nuclear CLK-1; 1.4 Response Signals with the Functions to Defend Against the Oxidative Stress; 1.4.1 Superoxide Dismutases (SODs); 1.4.1.1 SOD-1; 1.4.1.2 SOD-2 and SOD-3; 1.4.1.3 SOD-4; 1.4.1.4 SOD-5; 1.4.2 Catalases (CATs); 1.4.3 Insulin Signaling 1.6 Molecular Basis for Induction of Oxidative Stress in Nematodes Exposed to Environmental Toxicants1.6.1 Alteration in Primary Molecular Mechanism for the Control of Oxidative Stress Induced by Environmental Toxicants; 1.6.2 Induction of Expression for Proteins with the Functions to Defend Against the Oxidative Stress Induced by Environmental Toxicants; 1.6.3 Suppression in Expressions of Genes Mediating the Protection Response Defending Against Oxidative Stress in Nematodes After Chronic Exposure to Certain Environmental Toxicants