BookKeith A. Foster, editor.
Summary: Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins, and is both up to date and authoritative.
Contents:
Overview and history of botulinum neurotoxin research and exploitation
Pharmacology of botulinum neurotoxins
Absorption and transport of botulinum neurotoxins
The botulinum neurotoxin complex and the role of ancillary proteins
Neurotoxin structure
The dual receptor recognition of botulinum neurotoxins
Translocation, entry into the cell
Protease activity of the botulinum neurotoxins
Molecular basis for persistence of botulinum neurotoxins
Clostridium botulinum genomes and genetic diversity
Botulinum neurotoxin risks and detection in environment, agriculture and food chains
Botulism as a disease of humans
Prevention and treatment of botulism.