BookPavan Muttil, Nitesh K. Kunda, editors.
Summary: This book focuses on the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes.It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. Mucosal Delivery of Drugs and Biologics in Nanoparticles emphasize the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs. It acknowledges the concerns around the potential toxicity of nanoparticles to the host; few chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host's immune cells is discussed. Moreover,it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book will be the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.
Contents:
Section I Background
Introduction to Nanomedicine
Characterization of Nanoparticles
Section II Drugs and Biologics Encapsulated in Nanoparticles
Routes of Delivery
Small molecule Delivery
Peptide and Protein Delivery
Gene Delivery (siRNA/CRISPR)
Phage Therapy
Section III Diseases
Non-infectious Diseases
Infectious Diseases
Cancer
Section IV Host Interactions with Nanoparticles
Interaction of Nanoparticles with Epithelial and Immune Cells
Toxicity of Nanoparticles to the Host
Nanoparticle Pharmacokinetics and Pharmacodynamics
Section V MIscellanous
Nanoparticles as Theranostics
Regulatory Perspectives
Manufacturing Scale-up of Nanoparticles.