BookMasahiro Kizaki, editor.
Contents:
1. Identification and biology of CML stem cells
2. Molecular mechanisms of CML stem cell maintenance
3. Roles for signaling molecules in the growth and survival of CML cells
4. Goals of CML treatment in the tyrosine kinase inhibitor era
5. Biomarkers for determining the prognosis of CML
6. Updated European LeukemiaNet recommendations for the management of CML
7. Optimal monitoring of CML treatment: molecular and mutation analysis
8. Recommendations for the management of CML in the era of second-generation TKIs
9. The role of new TKIs and combinations with interferon-α for the treatment of CML
10. Safety profiles of first-line TKIs and managing adverse effects
11. Molecular mechanism of TKI resistance and potential approaches to overcome resistance
12. Discontinuation of therapy and treatment-free remission in CML.