Bookedited by Hubert Hilbi.
Summary: Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
Contents:
From Amoeba to Macrophages: Exploring the Molecular Mechanisms of Legionella pneumophila Infection in Both Hosts / Pedro Escoll and Monica Rolando
The Legionella pneumophila Two-Component Regulatory Systems that Participate in the Regulation of Icm/Dot Effectors / Gil Segal
Facets of Small RNA-Mediated Regulation in Legionella pneumophila / Hana Trigui, Nilmini Mendis and Laam Li
Type II Secretion and Legionella Virulence / Nicholas P. Cianciotto
Effector Translocation by the Legionella Dot/Icm Type IV Secretion System / Jiazhang Qiu and Zhao-Qing Luo
Modulation of Small GTPases by Legionella / Roger S. Goody and Aymelt Itzen
Host Lipidation: A Mechanism for Spatial Regulation of Legionella Effectors / Stanimir S. Ivanov and Craig Roy
Phosphoinositide Lipids and the Legionella Pathogen Vacuole / Ina Haneburger and Hubert Hilbi
Legionella Phospholipases Implicated in Virulence / Katja Kuhle and Antje Flieger
Cytotoxic Glucosyltransferases of Legionella pneumophila / Yury Belyi, Thomas Jank and Klaus Aktories
Modulation of the Ubiquitination Machinery by Legionella / Andree Hubber, Tomoko Kubori and Hiroki Nagai
Host Signal Transduction and Protein Kinases Implicated in Legionella Infection / Andrew D. Hempstead and Ralph R. Isberg
Mouse Models of Legionnaires' Disease / Andrew S. Brown and Ian R. van Driel.
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