BookHina Younus, editor.
Summary: Throughout history black seeds, Nigella sativa seeds, have been highly revered for its medicinal properties. Thymoquinone (TQ), an active principle component of the volatile oil of black cumin seeds, is an emerging natural compound with a wide range of medical applications, and has several beneficial pharmacological actions i.e anti-oxidant, anti-diabetic, anti-inflammatory, anti-microbial, anti-tumor, anti-mutagenic, anti-epileptic, hepatoprotective, neuroprotective, and nephroprotective. As such, it is important to move TQ from the bench to bedside. This book illustrates the therapeutic importance of TQ, offering a detailed account of some of its molecular and therapeutic properties, and discussing in depth its anti-diabetic, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial, anti-epileptic and hepatoprotective actions. Lastly, the book examines the future prospects of TQ research and its use as a pharmaceutical.
Contents:
Intro; Preface; Contents; Contributors; About the Editor;
1: Introduction; 1.1 History of Using Black Cumin Seeds for Therapeutic Purposes; 1.2 Components of Nigella sativa Seeds; 1.3 Therapeutic Actions of Thymoquinone; References;
2: Antidiabetic Action of Thymoquinone; 2.1 Diabetes and Glycation; 2.2 Antidiabetic Action of N. sativa Seeds; 2.3 Antidiabetic Action of Thymoquinone (TQ); 2.4 Conclusions; References;
3: Anticancer Action of Thymoquinone; 3.1 Introduction; 3.2 Structure and Function of Thymoquinone; 3.3 Possible Mechanism of Action of Thymoquinone. 3.20 Nano-formulation of Thymoquinone and Its Role in Killing Cancel Cells3.21 Conclusion and Future Prospective; References;
4: Antioxidant and Anti-inflammatory Action of Thymoquinone; 4.1 Oxidative Stress and Antioxidants; 4.2 Antioxidant Action of Thymoquinone; 4.3 Anti-inflammatory Action of Thymoquinone; References;
5: Antimicrobial Action of Thymoquinone; 5.1 Introduction; 5.2 Antibacterial Activity; 5.3 Antiviral Activity; 5.4 Antifungal Activity; 5.5 Conclusions; References;
6: Hepatoprotective Action of Thymoquinone; 6.1 Introduction. 3.4 Action of Thymoquinone on Cancer3.5 Thymoquinone Action Against Cancer Through Modulation of Molecular Targets; 3.6 Cell Cycle; 3.7 Enzymes Linked with Cancer Initiation; 3.8 Growth Factors; 3.9 Protein Kinases; 3.10 Antioxidant Enzymes; 3.11 Apoptosis; 3.12 Transcription Factor; 3.13 P53 and PTEN Gene; 3.14 Phase I and Phase II Enzyme; 3.15 Androgen Receptor; 3.16 Telomerase; 3.17 Cellular Components/Microtubules Degradation; 3.18 Human Trial Study Based on Thymoquinone; 3.19 LD 50, Safety and Toxicity Level of Thymoquinone. 6.2 Protective Action of TQ Under In Vitro Conditions6.3 Protection of Isolated Mice/Rat Hepatocytes by TQ; 6.4 Protective Effect of TQ in Mice/Rat Liver Under In Vivo Conditions; 6.5 Conclusions; References;
7: Anti-epileptic Action of Thymoquinone; 7.1 Epilepsy; 7.2 Anti-epileptic Activity of TQ; 7.3 Role of TQ in Temporal Lobe Epilepsy (TLE); 7.4 Beneficial Interaction of TQ with Known Anti-epileptic Drugs; References;
8: Future Prospects and Conclusions; 8.1 Potential Use of Thymoquinone (TQ) in the Inhibition of Important Cell Signaling Pathways; 8.2 Inhibition of Akt Signaling.