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  • Peptides are used ubiquitously for studies in biology, biochemistry, chemical biology, peptide based medicinal chemistry, and many other areas of research. There is a number of marketed peptide drugs, and the prospects for the development of new peptide drugs are very encouraging. The second edition of Peptide Synthesis and Applications expands upon the previous editions with current, detailed methodologies for peptide synthesis. With new chapters on laboratory protocols for both the specialist and the non-specialist. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis and Application, Second Edition seeks to aid scientists in understanding different approaches to the synthesis of peptides by using a broad range of methods and strategies.
  • Peptide-based drug design 2008
    Springer Protocols
    Peptide-based drug design : here and now / Laszlo Otvos, Jr. -- Strategies for the discovery, isolation, and characterization of natural bioactive peptides from the immune system of invertebrates / Philippe Bulet -- Sequence analysis of antimicrobial peptides by tandem mass spectrometry / Christin Stegemann and Ralf Hoffmann -- The spot technique : synthesis and screening of peptide macroarrays on cellulose membranes / Dirk F.H. Winkler and William D. Campbell -- Analysis of A[beta] interactions using ProteinChip technology / Eleni Giannakis ... [et al.] -- NMR in peptide drug development / Jan-Christoph Westermann and David J. Craik -- Molecular dynamics simulations of peptides / Jeffrey Copps, Richard F. Murphy and Sandor Lovas -- Short linear cationic antimicrobial peptides : screening, optimizing, and prediction / Kai Hilpert, Christopher D. Fjell and Artem Cherkasov -- Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach : a tool to identify new bacterial targets amenable to the design of novel antibiotics / Marco Scocchi ... [et al.] -- Serum stability of peptides / Håvard Jenssen and Stein Ivar Aspmo -- Preparation of glycosylated amino acids suitable for Fmoc solid-phase assembly / Mare Cudic and Gayle D. Burstein -- Synthesis of O-phosphopeptides on solid phase / David Singer and Ralf Hoffmann -- Peptidomimetics : Fmoc solid-phase pseudopeptide synthesis / Predrag Cudic and Maciej Stawikowski -- Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines / Brandon Y. Chua, Weiguang Zeng and David C. Jackson -- Synthesis of a multivalent, multiepitope vaccine construct / Laszlo Otvos, Jr. -- Cysteine-containing fusion tag for site-specific conjugation of therapeutic and imaging agents to targeting proteins / Marina V. Backer ... [et al.].
  • The perception-action cycle is the circular flow of information that takes place between the organism and its environment in the course of a sensory-guided sequence of behaviour towards a goal. Each action causes changes in the environment that are analyzed bottom-up through the perceptual hierarchy and lead to the processing of further action, top-down through the executive hierarchy, toward motor effectors. These actions cause new changes that are analyzed and lead to new action, and so the cycle continues. The Perception-action cycle: Models, architectures and hardware book provides focused.
  • This book provides a comprehensive source for all aspects of percutaneous image-guided biopsy. A synthesis of rationale, technique and evidence-based medicine, it offers a clear approach to imaging, devices, procedures and patient care.
  • Percutaneous aortic valve replacement and percutaneous mitral valve repair are emerging alternatives for high-risk patients with severe valve disease. Interventional cardiologists are faced with the challenge represented by this complex procedure. This practical guide specifically deals with a comprehensive knowledge of the techniques and approach to percutaneous treatment of left side cardiac valve disease and discusses the potential complications and expected or potential morbidity from the procedure.
  • Leading authorities on percutaneous tumor ablation come together in this volume to provide a complete overview of everything physicians and other health professionals need to know to successfully implement and administer an image-guided ablation service. After an introduction to the protocols and attendant physics of ablation technology, concise organ-based chapters focus on a wide range of both straightforward and atypical cases to teach readers how to handle the unique clinical and technical challenges associated with percutaneous tumor ablation in different areas of the body. Succinct, step-by-step descriptions complement high-resolution images throughout to illustrate the nuances of each procedure. This must-have clinical reference will develop the technical and clinical tumor ablation skills of every fellow and practicing physician in interventional radiology, oncology, and surgical oncology.
  • "Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. The book's comprehensive scope and abundantly illustrated format provide you with better understanding of the natural history of cancer, the physical methods of radiation application, the effects of radiation on normal tissues, and the most judicious ways in which you can employ radiation therapy in patient care. Traditionally available as a printed textbook, now it comes with acompletely revamped digital experience, powered by Inkling! NEW to the Sixth Edition ... site-specific chapters include relevant background information on each tumor including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results, and more. Over 1,400 full-color illustrationshighlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy. Increased emphasis on new approaches and technologies improve your understanding of three-dimensional treatment planning, intensity-modulated radiotherapy, combined modality therapy, and particle therapy. Greater emphasis on palliative and supportive carereflects the role of radiation treatment in non-curative roles. New editors and contributors let you benefit from their decades of experience. Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into the text, and much more."
  • Often times the symptoms of pericardial disease such as fever, chest pain, and shortness of breath are non-specific, making an accurate diagnosis a challenging task. Now, you can detect and treat pericardial disease in time to save many more patients. This title in the brand-new Clinical Diagnostic Imaging Atlas Series offers you authoritative guidance from a well-known cardiologist and imaging expert about when and how to perform the latest diagnostic imaging tests, interpret the results, and effectively treat the emergency. Detailed discussions of hot topics, full-color illustrations, and a DVD of procedural video clips, animations, and downloadable image libraries help you provide fast, appropriate treatment for each challenging case you face. Offers detailed advice on when and how to screen for the most prevalent but often difficult-to-diagnose pericardial diseases to help you improve care and increase survival rates. Discusses the hottest topics in pericardial disease, including imaging of the pericardium ₅ pericarditis₅ pericardial effusions ₅ pericardial tamponade ₅ pericardial constriction ₅ masses and encasement of the pericardium ₅ pneumopericardium ₅ and more that help you quickly diagnose the non-specific symptoms associated with pericardial disease. Presents 49 fully illustrated case presentations with teaching points that make information easy to understand and digest. Addresses the advantages and limitations of chest radiology, transthoracic and transesophageal echocardiography, cardiac CT, MR, angiography, and nuclear cardiology techniques so you can quickly determine the best imaging approach. Includes supporting evidence and current AHA/ACC guidelines for more accurate interpretations of your imaging findings. Uses a consistent, easy-to-follow chapter format that includes topic overview, an outline of imaging/diagnostic options, and case-based examples to make reference easy. Provides more than 400 full-color illustrations for expert visual guidance. Includes a bonus DVD containing 100 hundred videos of techniques and animations that show you what to look for and how to proceed as well as downloadable image libraries for use in electronic presentations.
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    We provide a broad overview of human brain development with associated malformations and injuries that occur in the period between early embryogenesis and delivery. The aim of this review is to summarize current understanding of the molecular and environmental cues that shape the developing brain. For each developmental stage, we give examples of disorders that arise from genetic and/or environmental insults to illustrate critical points of neurological susceptibility.
  • Perinatal Depression among Spanish-Speaking and Latin American Women:A Global Perspective on Detection and Treatment. As more is known about postpartum depression, the more it is recognized as a global phenomenon. Yet despite the large numbers, information about this condition as experienced by Spanish speaking women and Latinas has not always been easy to come by. Perinatal Depression among Spanish-Speaking and Latin American Women focuses on four diverse Latina populations (Mexico, Chile, Spain, and U.S.) to analyze key similarities and differences within this large and wide-ranging group. This first-of-its-kind reference reviews current research on the topic, including prevalence, screening methods, interventions, and--of particular salience for this population--barriers to care. Findings on psychoeducation, assessment tools, and cognitive-behavioral and other forms of therapy provide important insights into best practices, and continuity of care. And psychosocial, cultural, and linguistic considerations in working with Latinas are described in depth for added clinical usefulness. This landmark volume: Outlines characteristics of Spanish-speaking women and Latinas screened for postpartum depression Introduces the Edinburgh Postnatal Depression Scale, English and Spanish versions, and reviews their use with Latina women Compares postpartum depression and health behaviors in Spanish and Latina immigrant mothers Offers streamlined assessment-to-intervention models Provides two in-depth case studies illustrating cultural factors influencing the treatment of Latinas with perinatal depression Presents an instructive firsthand account of postpartum depression. Between its thorough coverage of the issues and its innovative clinical ideas, Perinatal Depression among Spanish-Speaking and Latin American Women has a wealth of information of interest to researchers and practitioners in maternal and child health, obstetrics/gynecology, mental health, and women's health.
  • Introduction / Melisa M. Adams -- Reproductive Health Issues / Melisa M. Adams -- Maternal Morbidity / Melisa M. Adams -- Maternal Mortality / Melisa M. Adams -- Infant Morbidity / Melisa M. Adams -- The Continuum of Reproductive Loss from Pregnancy Through Infancy / Melisa M. Adams -- Birth Weight, Gestational Duration, and Fetal Growth / Melisa M. Adams -- Conclusion / Melisa M. Adams.
  • "Preface Humans, like all mammals, have an inborn desire to nurture and suckle their young and the act of feeding is important for the bonding between mother and child. The birth of a critically ill preterm infant disrupts this, but for a mother, the use of her milk to feed her infant may be the most tangible role she has in the medical care of her critically sick child. Parents and caregivers see growth and feeding as important milestones first demonstrating increasing stability, then signaling the start of recovery, and finally showing readiness for discharge home. Despite our intuitive and emotional connection with growth, preterm infants grow poorly after birth and very commonly develop ex utero growth restriction (EUGR) or postnatal growth failure. There are many reasons for this including the associated medical conditions of prematurity, but inadequate nutrient intake plays a large part. This results both from technical difficulties in providing adequate nutrition, and from fears about the complications associated with doing so, including metabolic derangements such as hyperglycemia and hyperlipidemia, and diseases such as necrotizing enterocolitis. At the time of hospital discharge, many preterm infants are profoundly growth retarded, and their average weight is as little as 70% of that expected for their peers who were not born prematurely. Preterm infants show variable amounts of catchup growth after discharge, but typically remain smaller than the term-born peers throughout childhood and adolescence. This pattern of early growth restriction followed by variable amounts of catch-up growth has drawn parallels with the in utero growth restricted (IUGR), small-forgestational age, infant"--Provided by publisher.
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    v.1 Reproductive health; v.2 Reproductive risk.
  • Perinatal patient safety and professional liability issues / Kathleen Rice Simpson -- Integrating cultural beliefs and practices when caring for childbearing women and families / Lynn Clark Callister -- Physiologic changes of pregnancy / Susan Tucker Blackburn -- Antenatal care / Mary Lee Barron -- Hypertensive disorders of pregnancy / Judith H. Poole -- Bleeding in pregnancy / Mary Ellen Burke Sosa -- Preterm labor and birth / Nancy Jo Reedy -- Diabetes in pregnancy / Julie M. Daley -- Cardiac disease in pregnancy / Julie Arafeh -- A pulmonary complications in pregnancy / Suzanne McMurtry Baird and Betsy B. Kennedy -- Multiple gestation / Nancy A. Bowers -- Obesity in pregnancy / Mary Ann Maher -- Maternal fetal transport / Judy Wilson-Griffin -- Labor and birth / Kathleen Rice Simpson and Nancy O'Brien-Abel -- Fetal assessment during labor / Audrey Lyndon, Nancy O'Brien Abel, and Kathleen Rice Simpson -- Pain in labor : nonpharmacologic and pharmacologic management / Carol Burke -- Postpartum care / Dotti C. James -- Newborn adaptation to extrauterine life / Debbie Fraser -- Newborn physical assessment / Lyn Vargo -- Newborn nutrition / Jill Janke -- Common neonatal complications / Joan Renaud Smith and Annette Carley.
  • A historical perspective on the psychiatry of motherhood / I. Brockington -- Diagnostic classification of perinatal mood disorders / A. Riecher-Rössler, A. Rohde -- Maternal adversity, vulnerability, and disease / S.G. Matthews, M.J. Meaney -- Behavioral perinatology / P.D. Wadhwa -- Maternal depression: an adverse early environment / A.J. Beach ... [et al.] -- Perinatal infanticide and suicide / M.G. Spinelli -- Relevance of gonadal hormones to perinatal mood and anxiety disorders / A. Ahokas ... [et al.] -- Pharmacotherapy for psychiatric disorders in pregnancy / L.E. Ross ... [et al.] -- Maternal depression in the postpartum period: impact of breast-feeding on treatment planning / Z.N. Stowe, K. Ragan, D.J. Newport -- The use of interpersonal psychotherapy for perinatal mood and anxiety disorders / S. Stuart, M.W. O'Hara -- Group psychotherapy for depression in early stages of motherhood / M. Hofecker-Fallahpour, A. Riecher-Rössler -- Alternative treatment strategies for perinatal depression and anxiety / M. O'Higgins, V. Glover, M. Corral.
  • Subgingival biofilm structure / V. Zijnge, T. Ammann -- Microbial diversity and interactions in subgingival biofilm communities / P.I. Diaz -- Innate cellular responses to the periodontal biofilm / M. Benakanakere, D.F. Kinane -- Neutrophils in periodontal inflammation / D.A. Scott, J.L. Krauss -- Antimicrobial peptides in periodontal innate defense / S.-U. Gorr -- Modern approaches to non-surgical biofilm management / D.A. Apatzidou -- Animal models to study host-bacteria interactions involved in periodontitis / D.T. Graves ... [et al.] -- Antimicrobial advances in treating periodontal diseases / A. Mombelli -- Regenerative periodontal therapy / D.W.K. Kao, J.P. Fiorellini -- Paradigm shift in the pharmacological management of periodontal diseases / H. Hasturk, A. Kantarci, T.E. Van Dyke.
  • Part I: Preoperative Conditions -- General Principles and Practices of Perioperative Medicine -- The Prevalence of Disabling Musculoskeletal Conditions and the Demand for Orthopedic Surgery in the 21st Century -- The Connective Diseases: The Rheumatologist's Perspective -- The Pathophysiologic Events of Total Joint Replacement Surgery -- Part II: Anesthesiological Management -- Anesthesiology in the Orthopedic Patient -- Pediatric Anesthesia for Orthopedic Surgery -- Anesthetic Techniques and Their Clinical Application for Specific Orthopedic Procedures -- The Role of the Post-Anesthesia Care Unit in the Perioperative Care of the Orthopedic Patient -- Postoperative Pain Management in the Orthopedic Setting -- Part III: Medical Management in Specific Clinical Settings -- Perioperative Care of the Orthopedic Patient with Connective Tissue Disease -- Perioperative Care of the Orthopedic Patient with Cardiac Disease -- Perioperative Care of the Orthopedic Patient with Chronic Pulmonary Disease -- Perioperative Care of the Orthopedic Patient with Renal Disease -- Perioperative Care of the Orthopedic Patient with Diabetes Mellitus -- Perioperative Care of the Orthopedic Patient with Gastrointestinal and Liver Issues -- Perioperative Care of the Orthopedic Patient with Neurological Disease -- Perioperative Care of the Orthopedic Patient with Psychiatric Disease -- Part IV: Specific Perioperative Problems in Orthopedic Surgery -- Perioperative Care of the Elderly Orthopedic Patient -- Venous Thromboembolism and Orthopedic Surgery -- Coagulation Disorders and Orthopedic Surgery -- Perioperative Nutrition in the Orthopedic Surgical Patient -- Infection and Perioperative Orthopedic Care -- Risk and Benefits of Bilateral Total Knee Replacement Surgery -- Compartment Syndrome and Orthopedic Surgery: Diagnosis and Management -- Bone Health and Orthopedic Surgery -- Perioperative Care of theComplex Spine and Scoliosis SurgeryPatient -- Management of Blood Products in Orthopedic Surgery -- Part V: Role of Allied Services -- Professional Nursing Practice in the Orthopedic Care Setting -- The Approach to Physical Therapy Following Orthopedic Reconstructive Surgery -- Quality Improvement in the Perioperative Orthopedic Setting -- Introduction of Clinical Pathways in Orthopedic Surgical Care: The Experience of the Hospital for Special Surgery -- Ethical Considerations in Perioperative Orthopedic Medicine.
  • This book is written by experts in ultrasonography, it follows an evidence-based-medicine approach, exploring the latest ultrasound applications for regional anesthesia and pain relief procedures, as well as diagnostic and critical care medicine. A companion DVD shows you how to perform the techniques discussed in the text.
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  • All anesthesiologists are confronted with patients who show bleeding disorders, whether congenital, acquired, or pharmacologically induced. Although many studies, meta-analyses, guidelines, and textbooks have been published on the subject, they mostly cover specific aspects or require a thorough knowledge of hemostasis. The goal of this book is to provide the anesthetist with an overview of hemostasis and the mechanisms underlying bleeding and coagulation in general and to assist in the understanding of specific coagulation disorders as they may occur in the various anesthetic subspecialties. It is hoped that, through the provision of practical information and tools, the book will help residents and trained anesthetists to manage one of the most frustrating challenges that they face: the bleeding patient. A full understanding of coagulation requires a lifelong career, and this book is not intended to replace the consulting hematologist, whose expert opinion should always be sought. The available procoagulant blood products and drugs all have potentially dangerous side-effects; furthermore, in bleeding disorders pitfalls are frequent and a misdiagnosis can have potentially catastrophic consequences. The aim of the editors is thus instead to enhance the collaboration between the disciplines of Anesthesiology and Hematology.
  • The kidneys participate in all vital processes of the body to maintain overall homeostasis and health. When kidneys are injured during surgical interventions, metabolic and hemodynamic control is disrupted, leading to dysfunction associated with greater mortality, length of hospital stay, and cost. Peri-operative Kidney Injury presents the epidemiology, risk factors, diagnosis, treatment, and outcomes associated with kidney injury during the peri-operative period. Concepts and principles of care to prevent kidney complications during surgical procedures are provided to equip health care professionals along with strategies to manage acute kidney injury and associated challenges when they occur. Chapters detail diverse surgical settings, ranging from the more common, such as abdominal, cardiac, and vascular surgeries, to the intricately complex, including the use of the left ventricular assist device and organ transplants. This practical and comprehensive text blends the evidence-based standards of care with cutting edge advances in the field, while also providing the reader with a peek into innovations on the horizon.
  • Role of the Medical Consultant -- Preoperative Testing -- Perioperative Medication Management -- Perioperative Management of Anticoagulation -- Venous Thromboembolism Prophylaxis -- Prevention of Infective Endocarditis (Bacterial Endocarditis Prophylaxis) -- Surgical Site Infection Prophylaxis -- Anesthesiology for the Nonanesthesiologist -- Abdominal Surgery -- Thoracic Surgery -- Vascular Surgery -- Orthopedic Surgery -- Neurosurgery -- Gynecologic Surgery -- Urologic Surgery -- Bariatric Surgery -- Ophthalmic Surgery -- Otolaryngologic Procedures -- Electroconvulsive Therapy -- Cardiac Disease -- Pulmonary Disease -- Endocrine Disease -- Hematologic Disease -- Cancer -- HIV -- Chronic Kidney Disease -- GI Disease -- Rheumatic Disease -- Neurological Disease -- Psychiatric Conditions -- Substance Abuse -- The Pregnant Surgical Patient -- Postoperative Fever -- Postoperative Hypertension/Hypotension -- Postoperative Arrhythmias -- Perioperative Chest Pain/Dyspnea -- Postoperative Pulmonary Complications -- Postoperative Venous Thromboembolism (DVT and PE) -- Postoperative Fluid, Electrolyte, and Acid/Base Disorders -- Postoperative Renal Failure -- Anemia and Bleeding -- Postoperative Jaundice -- Postoperative Stroke and Seizures -- Postoperative Delirium -- Pain Management.
  • This resource presents best management approaches for achieving optimal perioperative outcomes. It reviews the potential risks to all major organ systems by examining the incidence and significance of organ dysfunction, assessing the etiology of particular organ dysfunctions, defining the preoperative and intraoperative risk factors and offering perioperative protection strategies to minimize potential complications. A consistent chapter format combined with color-coded algorithms, summary tables and boxes enable you to quickly locate specific guidance.
  • Principles and the normal heart -- Getting started with echocardiography: the twenty standard views -- Principles and physics: principles of ultrasound -- Principles and physics: principles of Doppler ultrasound -- Principles and physics: equations to remember (the Bernoulli equation, velocity-time integrals, and the continuity equation) -- Principles and physics: transducer characteristics -- Principles and physics: imaging artifacts and pitfalls -- Normal anatomy and flow during the complete examination: components of the complete examination -- Normal anatomy and flow during the complete examination: epiaortic imaging -- Normal anatomy and flow during the complete examination: three-dimensional views: replicating the surgeon's view -- Normal anatomy and flow during the complete examination: extracardiac anatomy -- Quantitative and semiquantitative echocardiography: dimensions and flows -- Quantitative and semiquantitative echocardiography: ventricular and valvular physiology -- Understanding how transesophageal echocardiography demonstrates cardiovascular pathology -- Myocardial ischemia and aortic atherosclerosis -- Aortic valve anatomy and embryology -- Mitral valvular disease -- Tricuspid valvular disease -- Pulmonic valvular disease -- Cardiomyopathies -- Aneurysms and dissections -- Endocarditis -- Imaging of cardiac tumors and solid and gaseous materials -- Intracardiac devices, catheters, and cannulas -- Echocardiographic evaluation of pericardial disease -- Adult congenital heart disease -- Pulmonary hypertension -- Recent advances -- Maintaining quality of perioperative echocardiography -- Indications for transesophageal echocardiography -- Complications of transesophageal echocardiography -- Equipment, infection control, and safety -- Oversight and administration -- Training and certification for transesophageal echocardiography -- Medical insurance claims, compliance, and reimbursement for anesthesiology -- Regulatory, legal, and liability issues pertaining to transesophageal echocardiography.
  • A history of transfusion / Bruce Spiess and Richard K. Spence -- The contemporary economics of transfusion / Timothy J. Hannon and Kathy Paulson Gjerde -- Blood supplies now and in the future / Mike Fitzpatrick -- Medical ethics, transfusion and the standard of practice / Kenneth Kipnis -- Oxygen transport monitoring: the basis for developing transfusion triggers / Kevin Ward and Ivo Torres Filho -- Physiology of anemia and red blood cell transfusion / Howard Corwin and Paul C. Høbert -- Physiology of hemostasis / Wayne L. Chandler -- Platelet physiology: cellular and protein interactions / Christine S. Rinder -- Iron metabolism and erythopoiesis / Kenneth R. Bridges -- New concepts in oxygen transport / Aryeh Shander, Tanuja S. Rijhwani, and Carmine Gianatiempo -- Infectious risks of transfusion / Eberhard W. Fiebig and Michael P. Busch -- Immunomodulation by transfusion / Neil Blumberg and Joanna M. Heal -- Serious acute transfusion reactions / Ira A. Shulman and Aryeh Shander -- A surgeon's guide to blood banking and transfusion medicine / Kimberly W. Sanford and Susan D. Roseff -- Blood storage / Ian Chin-Yee and Richard K. Spence -- Quality control and hospital blood utilization / Kathy Walsh-Kaminsky -- Preoperative autologous donation / F. Mercuriali, G. Inghilleri, and Richard K. Spence -- Erythropoetin therapy / Lawrence T. Goodnough -- Hemoglobin based oxygen carriers / Gregory M.T. Hare and C. David Mazer -- Perfluorocarbon emulsions: artificial gas transport media / Bruce D. Spiess -- Initial resuscitation of the hemorrhaging patient / Richard P. Dutton -- Transfusion and coagulation therapy in trauma and burns / James K. Wright, Harriet W. Hopf, and Lewis J. Kaplan -- Acute gastrointestinal bleeding and transfusion management / Richard Peterson, Patricia Parce, and Richard K. Spence -- Coagulation in trauma: dilution and massive transfusion / Richard K. Spence and Anthony Martinez -- Coagulation product use in the perioperative period / Richard K. Spence and Aryeh Shander -- Coagulation monitoring in the perioperative period / Linda Shore-Lesserson and Bruce D. Spiess -- Surgery in patients with acquired platelet and clotting deficiencies / Richard K. Spence and Andrew Green -- Surgery in patients with congenital clotting deficiencies / Richard K. Spence and Andrew Green -- Perioperative implications of anticoagulant and antiplatelet therapy / Jeffrey A. Green -- Pharmacological approaches to prevent or decrease bleeding in surgical patients / Jerrold H. Levy -- Fibrin glue and platelet gel / Bruce Searles and Cody Trowbridge -- Anesthesia techniques in blood conservation / Aryeh Shander and Tanuja Rijhwani -- Perioperative red cell salvage and autotransfusion / Jonathan H. Waters -- Intraoperative acute nomovolemic hemodilution / Aryeh Shander and Tanuja S. Rijhwani -- Hypothermia and hemorrhage / Richard P. Dutton -- Surgery in patients with red cell disorders: sickle hemoglobinopathies, polycythemia, and autoimmune hemolytic anemia / Imoigele P. Aisiku -- Surgery in the Jehovah's Witness / Richard K. Spence ... [et al.] -- Coagulation, transfusion, and cardiac surgery / Simon S. Body and David S. Morse -- Blood loss and transfusion alternatives in vascular surgery / Richard K. Spence -- Solid organ transplantation / Nicolas Jabbour, S. Ram Kumar, and Singh Gagandeep -- Blood use in orthopedic surgery / E. Michael Keating and John B. Meding -- Blood management in obstetrics and gynecology / Arnold J. Friedman -- Hemorrhage in pediatric patients / Thomas V. Whalen -- Transfusion in oncologic surgery / Patricia A. Ford and Jason Mastoris -- Transfusion and coagulation dysfunction in neurosurgery / Robert S. Graham and J. Chris Zacko -- Transfusion and outcome / Bruce D. Spiess, Richard K. Spence, and Aryeh Shander -- The transfusion decision / Bruce D. Spiess, Richard B. Counts, and Steven A. Gould -- Undertransfusion / Richard K. Spence and Aryeh Shander -- A philosophy of blood management / Aryeh Shander, Richard K. Spence, and Bruce D. Spiess.
  • Normal TEE Views -- Doppler and Hemodynamics -- Ventricles -- Native Valves -- Prosthetic Valves Transcatheter Valves and Valve Repairs -- Aorta -- Congenital Heart Disease -- Variants, Foreign Material, Masses and Endocarditis -- Ventricular Assist Devices and Heart Transplant -- Hypertrophic Obstructive Cardiomyopathy and Diastolic Dysfunction -- Pericardium.
  • Peripheral and cerebrovascular disease / Vijay Nambi and Deepak L. Bhatt -- Lower extremity intervention / Samir K. Shah and Daniel G. Clair -- Critical limb ischemia / Raghotham Patlola and Craig Walker -- Renal and mesenteric intervention / Ramy A. Badawi and Christopher J. White -- Subclavian and upper extremity interventions / Khung Keong Yeo and John R. Laird -- Carotid and vertebral intervention / Douglas E. Drachman, Nicholas J. Ruggiero II and Kenneth Rosenfield -- Intracranial intervention / Muhammad Shazam Hussain and Rishi Gupta -- Abdominal and thoracic aortic aneurysms / Aravinda Nanjundappa ... [et al.] -- Venous intervention / Andrew B. McCann and Robert M. Schainfeld.
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  • Evolution of endovascular therapy: diagnostics and therapeutics -- Pathophysiology of vascular disease -- Training and credentialing in vascular and endovascular surgery -- Assessment of vascular patients and indications for therapy -- Anesthesia techniques for endovascular surgery -- Intraprocedural monitoring for endovascular procedures -- Safety considerations for endovascular surgery -- Endovascular intervention suite design -- Angioscopy: instrumentation, techniques, and applications -- Duplex-guided balloon angioplasty from the carotid to the plantar arteries -- Intravascular ultrasound imaging -- Biomaterials: considerations for endovascular devices -- Ancillary endovascular equipment: catheters, guidewires, and procedural considerations -- Balloon angioplasty -- Endovascular intervention for lower extremity deep venous thrombosis -- Remote femoral and iliac artery endarterectomy -- Intravascular stents -- Intravascular laser technologies -- Endovascular devices for abdominal aortic aneurysms -- Endovascular devices for thoracic aortic aneurysms -- Critical limb ischemia -- Renal stents -- Inferior vena cava filters: the impact of endovascular technology -- Carotid stenting -- Neuroendovascular interventions -- The current status of hybrid repair of thoracoabdominal aortic aneurysms -- Laparoscopic aortic surgery -- Endovenous surgery -- Thoracic outlet syndrome: endoscopic transaxillary first rib approach: 23 years experience (1985-2008) -- Prevention of lesion recurrence in endovascular devices -- Management of the percutaneous puncture site -- Endovascular practice in Asia-Pacific -- Future imaging and guidance for endovascular procedures.
  • The new edition of this practical multimedia resource shows you exactly how to perform successfully a full range of peripheral nerve block techniques. Over four hundred illustrations, the majority of which are in colour, the relevant surface anatomy, the internal anatomy, the ultrasonographic anatomy to vividly depict correct needle placement in real patients.
  • Peripheral nerve disorders 2013
    "Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities"--Publisher's description.
  • The Peripheral Nervous System: Anatomy and Function -- Reactions to Injury -- Regeneration and Recovery of Function -- Clinical Aspects of Nerve Injury -- Operating on Peripheral Nerves.
  • History of peripheral nerve stimulation / Slavin, K.V. -- Central Mechanisms of Peripheral nerve stimulation in headache disorders / Bartsch, T., Goadsby, P.J. -- Peripheral nerve stimulation for chronic neurogenic Pain / Al-Jehani, H., Jacques, L. -- Percutaneous peripheral nerve stimulation / Al, K.M., Abramova, M.V., Richter, E.O. -- Peripheral nerve stimulation for the treatment of truncal pain / Cairns, K.D., McRoberts W.P., Deer, T. -- Peripheral subcutaneous stimulation for intractable abdominal pain / Barolat, G. -- Subcutaneous occipital region stimulation for intractable headache syndromes / Weiner, R.L. -- Peripheral nerve stimulation for occipital neuralgia: surgical leads / Kapural, L., Sable, J. -- Occipital nerve stimulation: technical and surgical aspects of implantation / Trentman, T.L., Zimmerman, R.S., Dodick, D.W. -- Peripheral neuromodulation for migraine headache / Ellens, D.J., Levy, R.M. -- Occipital neuromodulation for refractory headache in the chiari malformation population / Vadivelu, S., Bolognese, P., Milhorat, T.H., Mogilner, A.Y. -- Peripheral nerve stimulation in chronic custer headache / Magis, D., Schoenen, J. -- Peripheral nerve stimulation for fibromyalgia / Plazier, M. ... [et al.] -- Hybrid neurostimulator : simultaneous use of spinal cord and peripheral nerve field stimulation to treat low back and leg pain / Lipov, E.G. -- Stimulation of the peripheral nervous system for the painful extremity / McRoberts, W.P., Cairns, K.D., Deer, T. -- Sphenopalatine ganglion interventions: technical aspects and application / Oluigbo, C.O. ... [et al.] -- Spinal nerve root stimulation / Kellner, C.P., Kellner, M.A., Winfree, C.J. -- Technical aspects of peripheral nerve stimulation: hardware and complications / Slavin, K.V. -- Peripheral nerve stimulation: definition / Abejcentn, D., Perez-Cajaraville, J. -- The future of peripheral nerve stimulation / Stanton-Hicks, M. ... [et al.].
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    Basic concepts and glossary of common clinical terms -- Anatomic classification of peripheral nervous system disorders -- Evaluation and management of the patient with peripheral neuropathy -- Electrodiagnostic, imaging, nerve, and skin biopsy investigations in peripheral nerve diseases -- Case presentations illustrating the diagnostic method -- Acute immune-mediated neuropathies -- Chronic immune-mediated neuropathies -- Neuropathies associated with monoclonal gammopathies and cancer -- Infectious and granulomatous neuropathies -- Diabetic and other endocrine neuropathies -- Neuropathies associated with vitamin deficiencies and malabsorption -- Vascular/ischemic neuropathies -- Neuropathies associated with organ failure -- The hereditary neuropathies -- Hereditary metabolic/multisystem disorders with neuropathy -- The toxic neuropathies : principles of general and peripheral neurotoxicology, pharmaceutical agents -- The toxic neuropathies : industrial, occupational, and environmental agents -- Focal neuropathies : nerve injuries, entrapments, and other mononeuropathies -- Plexopathies -- Disorders of peripheral nerve hyperexcitability.
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    Ch. 1 Viewing the peripheral fundus -- Ch. 2 Anatomy of the peripheral fundus -- Ch. 3 Developmental anomalies, degeneration, and diseases of the peripheral retina and pars plana -- Ch. 4 Vitreous degeneration related to peripheral retinal breaks and retinal detachment -- Ch. 5 Peripheral retinal breaks -- Ch. 6 Retinal detachment -- Ch. 7 Proliferative vitreoretinopathy -- Ch. 8 Choroidal detachment .
  • Peripheral vascular disease : basic and clinical perspectives / Erich Minar & Martin Schillinger -- Epidemiology, risk factors & prognosis / Beau M. Hawkins & Michael R. Jaff -- Clinical and noninvasive diagnosis / Wolfgang Mlekusch -- Lifestyle and exercise therapy for peripheral vascular disease / Curt Diehm & Nicolas Diehm -- Medical therapy for peripheral vascular disease / Rudolf Kirchmair & Peter Marschang -- Endovascular therapy for peripheral vascular disease / Martin Schillinger & Erich Minar -- Surgical approaches in peripheral vascular disease / Mehtab Ahmad & Andrew Bradbury -- Index.
  • General -- Material -- Methods -- Abdomen -- Lower extremities -- Upper extremities -- Other endovascular interventions -- Complications -- Recurrent stenosis -- Documentation and postprocessing.
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  • Diagnostic Biopsy Procedures -- Cutaneous Surgery -- Hand Surgery -- Foot Surgery -- Hernia Surgery -- Head and Neck Surgery.
  • Indications for central venous cannulation in critically ill patients have increased dramatically in recent years owing to the use of more complex therapies unsuitable for delivery via peripheral veins. The main drawbacks of central venous access are morbidity and the growing scarcity of experienced operators. Ultrasound-guided peripheral venous access offers a solution, in that it reduces morbidity and can be performed by a dedicated nursing team. The aim of this book is to teach the fundamentals of this emerging technique. Advice is provided on the choice of materials and on vein selection. The advantages and disadvantages of peripherally inserted central venous catheters (PICC) in relation to other types of central venous catheter are discussed, and the principles of use and practical applications of ultrasound for venipuncture are explained. Maneuvers for PICC positioning, techniques for the evaluation of PICC tip placement, and the prevention, diagnosis, and management of complications are all described in detail. Advice is also provided on the organization of a dedicated PICC team within a hospital or a supportive care program, and psychological, legal, and economic issues are considered. Peripherally Inserted Central Venous Catheters will be of interest to a wide range of professionals, including nutritionists, oncologists, anesthesiologists, surgeons, registered nurses, nurse practitioners, physicians, physician assistants, and radiologists.
  • Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.
  • Preface / Ronco, C -- The International Vicenza Course on Peritoneal Dialysis, 30 year anniversary / Nolph, KD -- Twenty years of bicarbonate solutions / Feriani, M -- Peritoneal dialysis solution and nutrition / Verger, C -- Alternative dialysis strategies with icodextrin / Panzer, SE; Teitelbaum, I -- Are current peritoneal dialysis solutions adequate for pediatric use? / Verrina, EE ...[et al.] -- Brazillan Peritoneal Dialysis Multicenter Study (BRAZPD), from conception to execturion of a national peritoneal dialysis reality check / Divino-Filho, JC ... [et al.] -- Comparing outcomes of hemodialysis and peritoneal dialysis patients, consider the pitfalls / Mehrotra R -- Hypogonadism in males with chronic kidney disease, another cause of resistance to erythropoiesis-stimulating agents? / Stenvinkel P; Barany P -- Getting the right patient on the right renal replacement therapy / Perez Fontan M ... [et al.] -- Doubts on the long-term survival of peritoneal dialysis patients are no longer a medical barrier to home dialysis / Lameire, N ; Van Biesen, W -- How to avoid technique failure in peritoneal dialysis patients? / Lobbedez, T ... [et al.] -- Clinical practice guidelines, an important tool in improving dialysis quality / Lamiere, N; Van Biesen, W -- Remote monitoring for continuous peritoneal dialysis / Rosner, MH; Ronco, C -- e-Health, remote health care models in peritoneal dialysis / Struijk, DG -- Remote monitoring of peritoneal dialysis in special locations / Nayak, A; Antony, S; Nayak, KS -- Dialysis modality choice for the elderly patient with end-stage renal disease / Rosner, MH; Ronco, C -- Anemia management in patients on peritoneal dialysis / Del Vecchio, L; Cavalli, A; Locatelli, F -- Maximizing the erythropoietin response, iron strategies / Prabhu, MV ... [et al] -- Lipid disorders in uremia and dialysis / Bakris, GL -- Statins and lipid-lowering strategies in PD / Heimburger, O -- Statin therapy is associated with decreased small, dense low-density lipoprotein levels in patients undergoing peritoneal dialysis / Clementi, A ... [et al.] -- Phosphate control in peritoneal dialysis / Cozzolino, M ... [et al.] -- Role of vitamin D receptor activators in peritoneal dialysis / Bover, J ... [et al.] -- Calcimimetics in peritoneal dialysis patients / Messa P; Castelnovo, C; Scalamogna, A -- Factors affecting loss of residual renal function(s) in dialysis / Raimann, JG; Kitzler, TM; Levin, NW -- Prospective safety study of bardoxolone methyl in patients with Type 2 diabetes mellitus, end-stage renal disease and peritoneal dialysis / Warnock, DG ... [et al.] -- Assessment of fluid status in peritoneal dialysis / Woodrow G; Ronco C -- Fluid transport and homeostasis in peritoneal dialysis / Teixido Planas, J -- Bioimpedance and brain natriuretic peptide in peritoneal dialysis patients / Crepaldi, C ... [et al.] -- Role of peritoneal dialysis as a chronic renal replacement therapy in cardiorenal patients / Pego, C; Rodrigues, A; Ronco, C -- Vascular and arterial calcification in peritoneal dialysis patients, state of the art 2012 / Heymann, EP; Penny, H; Goldsmith, DJA -- Adequacy in peritoneal dialysis / Ryckelynck, J-P ... [et al.] -- Setting up research in peritoneal dialysis -- Continuous flow peritoneal dialysis, update 2012 / Amerling, R; Winchester, JF; Ronco, C -- Combination therapy, five days PD and one day HD-what are the benefits? / Burkart, J -- Peritoneal dialysis access, what's the best approach? / Riella, MC; Chula DC -- Time between peritoneal dialysis catheter insertion and use / Elhassan E; Teitelbaum, I -- Peritoneal diallysis membrane evaluation in clinical practice / Krediet, RT; Struijk -- Bioelectrical impedance analysis in the assessment of hydration status in peritoneal dialysis patients / Haapio, M ... [et al.] -- Today's approaches to prevent peritonitis / Piraino, B -- Transplant outcomes and dialysis modality / Fuquay, R; Teitelbaum, I -- Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis, the case of neutrophil gelatinase-associated lipocalin / Martino, FK ... [et al.] -- Prognostic factors for peritonitis outcome / van Esch, S; Krediet, RT; Struijk, DG -- Improving the care of diabetic patients on peritoneal dialysis / Dalal, P; Misra, M -- How to select among dialysis options / Mooney, A.
  • 1. Anatomy of Peritoneum and Preoperative Assessment of Patients with Peritoneal Surface Malignancies -- 2. Surgical Technique for Cytoreductive Surgery -- 3. Intraperitoneal Chemotherapy Applications -- 4. Management of Special Issues -- 5. Molecular Mechanism of Peritoneal Metastases.
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  • Introduction: Formulation of the problem -- Normal or innocent murmurs -- Cardiac malpositions -- Isolated congenital complete heart block -- Congenital abnormalities of the pericardium -- Congenitally corrected transposition of the great arteries -- Congenital aortic stenosis: Congenital aortic regurgitation -- Coarctation of the aorta and interrupted aortic arch / Congenital obstruction to left atrial flow: Mitral stenosis, cor triatriatum, pulmonary vein stenosis -- Endocardial fibroelastosis -- Congenital pulmonary stenosis -- Congenital pulmonary valve regurgitation -- Ebstein's anomaly of the tricuspid valve -- Primary pulmonary hypertension -- Atrial septal defect: Simple and complex -- Pulmonary stenosis with interatrial communication -- Ventricular septal defect -- Ventricular septal defect with pulmonary stenosis -- Double outlet ventricle -- Patent ductus arteriosus aortopulmonary window -- Anomalous origin of the left coronary artery from the pulmonary trunk -- Congenital coronary arterial fistula -- Congenital aneurysms of the sinuses of valsalva -- Pulmonary atresia with intact ventricular septum -- Tricuspid atresia -- Univentricular heart -- Complete transposition of the great arteries -- Truncus arteriosus -- Congenital anomalies of vena caval connection -- Congenital pulmonary arteriovenous fistula -- Hypoplastic left heart -- Congenital anomalies of the coronary circulation.
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    "Permanent Present Tense tells the incredible story of Henry Gustave Molaison, known only as H. M. until his death in 2008. In 1953, at the age of twenty-seven, Molaison underwent a dangerous "psychosurgical" procedure intended to alleviate his debilitating epilepsy. The surgery went horribly wrong, and when Molaison awoke he was unable to store new experiences. For the rest of his life, he would be trapped in the moment. But Molaison's tragedy would prove a gift to humanity. The amazing specificity of his impairment shed new light on the functions and structures of the human brain, revolutionizing neuroscience. Today, the case of H. M. stands as one of the most consequential and widely referenced in this fast-expanding field. Renowned neuroscientist Suzanne Corkin worked with Molaison for nearly five decades. In Permanent Present Tense, she tells the full story of his life and legacy, leading her reader to the cutting edge of neuroscience with great clarity, sensitivity, and grace. "-- Provided by publisher.
  • Introduction / Leopold Flohé and J. Robin Harris -- Evolution of the peroxiredoxins / Bernard Knoops, Eléonore Loumaye and Valérie Van Der Eecken -- Structural survey of the peroxiredoxins / P. Andrew Karplus and Andrea Hall -- The catalytic mechanism of peroxiredoxins / Leslie B. Poole -- Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite / Madia Trujillo ... [et al.] -- The peroxiredoxin repair proteins / Thomas J. Jönsson and W. Todd Lowther -- Peroxiredoxins in bacterial antioxidant defense / James M. Dubbs and Skorn Mongkolsuk -- The NADH oxidase-Prx system in Amphibacillus xylanus / Youichi Niimura -- Peroxiredoxin systems in mycobacteria / Timo Jaeger -- Peroxiredoxin systems of protozoal parasites / Marcel Deponte, Stefan Rahlfs and Katja Becker -- The trypanothione system / Luise R. Krauth-Siegel, Marcelo A. Comini and Tanja Schlecker -- Functions of typical 2-Cys peroxiredoxins in yeast / Brian A. Morgan and Elizabeth A. Veal -- The dual function of plant peroxiredoxins in antioxidant defence and redox signaling / Karl-Josef Dietz -- Mitochondrial peroxiredoxins / Zhenbo Cao, J. Gordon Lindsay and Neil W. Isaacs -- Peroxiredoxins in the lung with emphasis on peroxiredoxin VI / Bruno Schremmer ... [et al.] -- Peroxiredoxins in gametogenesis and embryo development / Isabelle Donnay and Bernard Knoops -- Peroxiredoxins in the central nervous system / Fumiyuki Hattori and Shinzo Oikawa -- Stress-induced peroxiredoxins / Tetsuro Ishii and Toru Yanagawa.
  • PPARs : history and advances / Jihan Youssef and Mostafa Z. Badr -- PPAR-alpha cloning, expression, and characterization / Suong N.T. Ngo and Ross A. McKinnon -- PPARGC1A and PPARG genotyping : beginner's guide to genotyping with unlabeled probes / Viera Habalova and Jozef Židzik -- Generation of an inducible, cardiomyocyte-specific transgenic mouse model with PPAR [beta]/[delta] overexpression / Teayoun Kim [and others] -- Specific knockdown of PPAR[delta] gene in colon cancer cells by lentivirus-mediated RNA Interfering / Lie Yang, Zong-Guang Zhou, and Xiao-Feng Sun -- Dominant-negative and knockdown approaches to studying PPAR activity / Sudhir Singh and Robert G. Bennett -- Producing PPARgamma2 knockdown in mouse liver / Tomomi Yamazaki and Osamu Ezaki -- Adipose tissue-specific PPAR[gamma] gene targeting / Weimin He -- Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs / Nico Mitro [and others] -- PPAR SUMOylation : some useful experimental tips / Benoit Pourcet, Bart Staels, and Corine Glineur -- Analyzing phosphorylation-dependent regulation of subcellular localization and transcriptional activity of transcriptional coactivator NT-PGC-1[alpha] / Ji Suk Chang and Thomas W. Gettys -- In vivo studies of PPAR-chromatin interactions : chromatin immunoprecipitation for single-locus and genomewide analyses / Till Adhikary and Rolf Müller -- FISH analysis using PPAR[gamma]-specific probes for detection of PAX8-PPAR[gamma] translocation in follicular thyroid neoplasms / Noor Akmal Syed Husain Sharifah, Zubaidah Zakaria, and Wai Kit Chia -- Immunohistochemical techniques to identify and localize proteins of interest in paraffin embedded tissue sections / Carolyn M. Komar and Mary Jane Long -- Determination of PPAR expression by western blot / Aziz Guellich and Catherine Coirault -- Fluorescence resonance energy transfer techniques to study ligand-mediated interactions of PPARs with coregulators / Nico Mitro, Cristina Godio, and Maurizio Crestani -- Estimation of the PPAR[alpha] agonism of fibrates by a combined MM-docking approach / Fabio Lannutti, Alessandro Marrone, and Nazzareno Re -- Combined biophysical and cell-based approaches for the assessment of ligand binding to PPAR[gamma] / Silvia Zorrilla and Dolores Pérez-Sala -- Exploring PPAR modulation in experimental mice / Anna Rull [and others] -- Induction of adipogenic differentiation in three-dimensional culture model on a novel microfabricated scaffold / Yoshitaka Miyagawa, Hajime Okita, and Nobutaka Kiyokawa -- Analyzing PPAR[alpha]/ligand interactions by chemical cross-linking and high-resolution mass spectrometry / Mathias Q. Müller, Christian H. Ihling, and Andrea Sinz -- Synthesis, mass spectrometric characterization, and analysis of the PPAR[delta] agonist GW1516 and its major human metabolites : targets in sports drug testing / Mario Thevis [and others] -- LC-MS-based method for the qualitative and quantitative analysis of the novel PPAR[gamma] agonist KR-62980 / Min-Sun Kim and Myung Ae Bae -- Behavioral paradigms to evaluate PPAR modulation in animal models of brain injury / Dana Greene-Schloesser, Caroline I. Schnegg, and Mike E. Robbins.
  • Introduction -- History of PPAR Discovery -- Peroxisome Proliferator-Activated Receptors -- PPAR Ligands -- Tissue Distribution and Versatile Functions of PPARs -- PPARs and Drug Metabolism -- Molecular Aspects of PPAR Actions -- Animal Models in PPAR Research -- Safety of PPAR Agonists -- The Future of PPAR Research.
  • Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. In recent years it has become increasingly clear that peroxisomes are involved in a range of important cellular functions in almost all eukaryotic cells. In higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid alpha-oxidation, glyoxylate detoxification, etc, and in humans peroxisomes are associated with several important genetic diseases.
  • Scientific basis of cancer chemotherapy -- Norton-Simon hypothesis -- Drug resistance -- Principles of chemotherapy -- Clinical trials -- Hematopoietic growth factors -- Biologic response modifiers: principles of biotherapy -- Intraventricular and intrathecal therapy -- Intraperitoneal chemotherapy -- Intraarterial chemotherapy -- Hematopoietic stem cell transplantation -- Oral toxicity -- Dermatologic toxicity -- Extravasation -- Hypersensitivity reactions -- Ocular side effects of cancer therapeutics -- Cardiotoxicity of cancer therapy -- Pulmonary toxicity of chemotherapeutic agents -- Gastrointestinal complications of chemotherapy -- Hepatotoxicity of chemotherapeutic agents -- Chemotherapy-induced renal and electrolyte dysfunction -- Chemotherapy-induced peripheral neuropathy -- Vascular toxicity of antineoplastic agents -- Second malignancies after chemotherapy -- Chemotherapy in pregnancy -- Gonadal complications and teratogenicity of cancer therapy -- Central venous access for chemotherapy -- Systemic therapy for advanced melanoma -- Chemotherapy of primary brain tumors -- Chemotherapy for head and neck cancer -- Chemotherapy of lung cancer -- Breast cancer -- Gastrointestional cancer -- Endocrine tumors -- Chemotherapy of genitourinary cancer -- Chemotherapy of gynecologic cancers -- Chemotherapy of carcinoma of unknown primary site -- Chemotherapy of bone and soft tissue sarcomas -- Chemotherapy for pediatric solid tumors -- Chemotherapy for childhood leukemia -- Chemotherapy of Hodgkin lymphoma -- Non-Hodgkin lymphoma -- Chronic lymphocytic leukemia -- Acute myeloid leukemia -- Myelodysplastic syndromes -- Management of myeloproliferative disorders and chronic myeloid leukemia -- Chemotherapy of multiple myeloma -- Appendics: I: Chemotherapeutic agents -- II: Chemotherapy programs -- III: Common terminology criteria for adverse events (CTCAE) version 4.0.
  • The book revisits the causes of persisting undernutrition in India, but moves away from the usual focus on women and children to a broader view of the entire population. It estimates the economic losses resulting from ignoring undernutrition in the adult working population, and questions the current narrow focus of nutrition interventions, suggesting that a family-based approach may provide quicker results and long-term sustainability. It compares the best and worst performing states in the country to glean learnings from both successes and failures and emphasizes the need to hand over the ownership of nutrition outcomes from the state to the community and family for more sustainable results. The book is organized in three sections: Part 1 details the nutrition status of the population, regional variations in nutrition outcomes, and government response in terms of interventions. Part 2 reviews issues and concerns like gender discrimination, poor child nutrition status, ineffective implementation of government programmes in the field, and the possible impacts of emerging issues like climate change. Part 3 seeks solutions from both international and country experiences.
  • Inverted perspectives: triggering change / Tom Munnecke and Robert M. Kolodner -- A window of opportunity / Robert M. Kolodner -- HealthePeople: person-centered, outcomes-driven, virtual health systems / Gary A. Christopherson -- The value of electronic health records / Blackford Middleton -- Personal outcomes in health care / Thomas L. Garthwaite -- Human factors: changing systems, changing behaviors / Marion J. Ball and Judith V. Douglas -- Laying the foundations: information architecture for HealthePeople / James E. Demetriades -- Critical areas of standardization / Jeffrey S. Blair and Simon Cohn -- The role of terminology in future health information systems / Steven H. Brown, Michael J. Lincoln, and Peter L. Elkin -- Modeling for health care / Kenneth S. Rubin, Thomas Beale, and Bernd Blobel -- HealthePeople security architecture / Bernd Blobel and John M. Davis -- Open source health systems / Dipak Katra and David Forslund -- Critical standards convergence / Steven Wagner and J. Michael Fitzmaurice -- A European perspective on the cultural and political context for deploying the electronic health record / Angelo Rossi Mori and Gerard Freriks -- Convergence toward the Pan-Canadian electronic health record / Julie Richards, Shari Dworkin, and Nancy Gill -- HealthConnect: a health information network for all Australians / David Rowlands -- The Veterans Health Administration: quality, value, accountability, and information as transforming strategies / Jonathan B. Perlin and Robert M. Kolodner.
  • The next frontier for user-centered design : making user representations more usable -- The persona lifecycle : a framework for the persona approach -- Phase 1: Family planning (planning a persona effort) -- Phase 2: Conception & gestation (creating personas) -- Phase 3: Birth & maturation (launching and communicating personas) -- Phase 4: Adulthood (using personas) -- Phase 5: Lifetime achievement and retirement (ROI and reuse of personas) -- Contributed chapters: Users, roles and personas / by Larry Constantine -- Storytelling and narrative / by Whitney Quesenbery -- Reality and design maps / by Tamara Adlin & Holly Jamesen -- Marketing versus design personas / by Bob Barlow-Busch -- Why personas work : the psychological evidence / by Jonathan Grudin -- Appendix A: G4K organizational archetype and sample persona -- Appendix B: Example personas from real projects -- Appendix C: Sample image release form.
  • Another view of psychotherapy? / Herbert J. Schlesinger -- Personality in context : reflections on the contributions of David Shapiro / Paul L. Wachtel -- A new developmental foundation for David Shapiro's work on autonomy and character / E. Virginia Demos -- Two configurations of personality development and psychopathology : etiologic and therapeutic implications / Sidney J. Blatt -- Autonomy and schizophrenia : reflections on an ideal / Louis A. Sass -- Reconceptualizing defense, unconscious processes, and self-knowledge : David Shapiro's contribution / Morris N. Eagle -- Defensive styles of thinking to prevent dreaded states of mind / Mardi J. Horowitz -- Self-deceptive speech : a psycholinguistic view / Michael F. Schober and Peter J. Glick -- Neurotic self-deception as a reproductive strategy / Lawrence Josephs -- David Shapiro's characterology and complex systems theory / Craig Piers -- I don't want to want to : intentionality and craving in addiction / Mindy Greenstein -- Activity, passivity, and the subjective experience of hypomania / Andreas Evdokas and Ali Khadivi -- Appendix A : On two fundamental categories of psychopathology / David Shapiro -- Appendix B : Publications by David Shapiro.
  • Personalized management of breast cancer / Travis L. Holloway & Ismail Jatoi -- Diagnosis and biomarkers / Aysegul Sahin & Alexandra Shaye Brown -- Molecular subtypes of breast cancer / Henry O. Ebili, A. Olayiwola Oluwasola & Olufunmilayo I. Olopade -- Surgery and radiotherapy : patient selection and clinical outcomes / Travis Holloway & Ismail Jatoi -- Hormone-blocking therapy : patient selection and clinical outcomes / Annie R. Su & Mothaffar F. Rimawi -- EGF receptor inhibitors : patient selection and clinical outcomes / Sean Warsch, Gabriel Tinoco, Stefan Glück, Kiran Avancha & Alberto J. Montero -- Antiangiogenic therapy : patient selection and clinical outcomes / Sheeba Irshad, Andrew Tutt & Paul Ellis -- Current guidelines of breast cancer management / Cristina Falci, Zora Baretta & Silvio Monfardini -- Management algorithms of breast cancer / Paolo Carli, Loredana Militello, Elena Torrisi, Alessando Tuzi & Andrea Veronesi -- Index.
  • Personalized management of colorectal cancer / Alfredo Falcone & Fotios Loupakis -- Adjuvant treatment of stage II colon cancer : yes or no, what, when and why? / Joleen Hubbard & Daniel J. Sargent -- Adjuvant treatment of stage III colon cancer : where are we and will we ever move forward? / Benoît Rousseau & Christophe Tournigand -- Challenges in the neoadjuvant treatment of rectal cancer / Robert Glynne-Jones -- Molecular markers in radically resected colorectal cancer : from prognosis to prediction / Wu Zhang, Peter M. Wilson, Sebastian Stintzing & Heinz-Josef Lenz -- Liver-limited resectable stage IV : current reality and future perspectives / Dario Ribero & Simone Conci -- Choosing the right biologic agent in the 'continuum-of-care era' : a clinical perspective / Chiara Cremolini & Axel Grothey -- Index.
  • Current therapies for HNC : why is immunotherapy not yet in the forefront? / Theresa L. Whiteside -- Etiology and risk factors / Ana Neumann, Lei Jin & Qingyi Wei -- Molecular diagnostics of head and neck cancer / Diana Bell & Adel K. El-Naggar -- Classification and prevalence / Luiz Paulo Kowalski -- Surgery and radiotherapy : patient selection and clinical outcomes / Jonas T. Johnson -- Chemotherapy and molecularly targeted therapies for previously untreated SCCHN / Scott A. Kono, Nabil F. Saba & Dong M. Shin -- Chemotherapy and molecularly targeted therapies for recurrent head and neck cancer / Thomas K. Hoffmann & Patrick J. Schuler -- Prognostic biomarkers in squamous cell carcinoma of the head and neck / Vasu Divi & Carol Bradford -- Consensus guidelines / Carol M. Lewis & Randal S. Weber -- Index.
  • Personalized management of lung cancer / Ritsuko Komaki -- Molecular subtypes of non-small-cell lung cancer / Thomas E. Stinchcombe -- Screening and risk factors / Claudia I. Henschke, James P. Smith, David F. Yankelevitz & Rowena Yip -- Staging and prognosis / Elizabeth A. David, Daniel R. Gomez, Ritsuko Komaki & Garrett L. Walsh -- Surgical approach : patient selection and clinical outcomes / Boris Sepesi -- Radiotherapy : patient selection and clinical outcomes / Heath D. Skinner & Ritsuko Komaki -- Adjuvant therapy for non-small-cell lung carcinoma following surgical resection / Steven H. Lin -- Chemotherapy and molecularly targeted agents for advanced non-small-cell lung cancer / Charles Lu -- Use of thoracic radiation therapy for small-cell lung cancer / Steven E. Schild -- Limited-stage small-cell lung cancer : prophylactic cranial irradiation / Cecile Le Pechoux & Hweej Al Mokhles -- Small-cell lung cancer : treatment of extensive-stage disease / Lauren Averett Byers & John V. Heymach -- EGFR inhibitors : patient selections and clinical outcome / Rafael Rosell & Laura Bonanno -- Antiangiogenic therapy for non-small-cell lung cancer : patient selection and clinical outcomes / Suresh S. Ramalingam & Chandra P. Belani -- Considerations of practice guidelines and recommendations / Nan Bi & Feng-Ming (Spring) Kong -- Novel agents in development and future directions / George R. Simon -- Index.
  • Personalized management of multiple sclerosis / Bianca Weinstock-Guttman, Murali Ramanathan & Robert Zivadinov -- Epidemiology and classification / Julia Pakpoor & Sreeram V. Ramagopalan -- Pathophysiology of multiple sclerosis : a controversial new perspective / Johannes M. van Noort & Sandra Amor -- Symptoms and diagnosis of multiple sclerosis / Eva Havrdová & Jana Lizrova Preiningerova -- Management of acute multiple sclerosis attacks / Finn T. Sellebjerg -- Disease-modifying treatments for relapsing-remitting multiple sclerosis / Per Soelberg Sørensen -- Disease-modifying treatments for secondary progressive and progressive relapsing multiple sclerosis / Laura J. Edwards & Cris Constantinescu -- Head-to-head versus therapy-change studies / Carlo Pozzilli & Luca Prosperini -- MRI as a surrogate marker for clinical outcomes in multiple sclerosis / Maria Pia Sormani -- Measurement of cerebral atrophy in multiple sclerosis / Ernst-Wilhelm Radue, Kerstin Bendfeldt & Till Sprenger -- Symptomatic therapy for multiple sclerosis / Scott E. Jarvis, Aaron Mackie & Luanne M. Metz -- Neurologic rehabilitation in multiple sclerosis / Susan E. Bennett -- Treatment of pediatric multiple sclerosis / Angelo Ghezzi -- Complementary and alternative treatments / Allen C. Bowling -- Future directions in multiple sclerosis / Anat Achiron -- Index.
  • Opportunities and challenges in nutrigenetics/nutrigenomics and health / De Caterina, R. -- Genome-wide association studies and diet / Ferguson, L.R. -- Copy number variation, eicosapentaenoic acid and neurological disorders : with particular reference to Huntington's disease and associated CAG repeats and to myalgic encephalomyelitis and viral infection / Puri, B.K.; Manku, M.S. -- Nutrigenetics : a tool to provide personalized nutritional therapy to the obese / Marti, A.; Goyenechea, E.; Martínez, J.A. -- Xenobiotic metabolizing genes, meat-related exposures, and risk of advanced colorectal adenoma / Ferrucci, L.M. ... [et al.] -- Strategies to improve detection of hypertension genes / Hunt, S.C. -- Diet, nutrition and modulation of genomic expression in fetal origins of adult disease / Jackson, A.A.; Burdge, G.; Lillycrop, K. -- Choline : clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements / Zeisel, S.H. -- Dietary polyphenols, deacetylases and chromatin remodeling in inflammation / Rahman, I., Chung, S. -- Dietary manipulation of histone structure and function / Ho, E., Dashwood, R.H -- Changes in human adipose tissue gene expression during diet-induced weight loss / Svensson, P.-A. ... [et al.] -- Toxicogenomics and studies of genomic effects of dietary components / Thompson, K. -- Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis / Starlard-Davenport, A. ... [et al.] -- Redox dysregulation and oxidative stress in schizophrenia : nutrigenetics as a challenge in psychiatric disease prevention / Do, K.Q., Conus, P.; Cuenod, M. -- Nutrigenomics and agriculture : a perspective / Spence, J.T. -- Opportunities and challenges in nutrigenetics/nutrigenomics : building industry-academia partnerships / Gillies, P.J. ; Kris-Etherton, P.M. -- Tailoring foods to match people's genes in New Zealand : opportunities for collaboration / Ferguson, L.R. ... [et al.].
  • This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.
  • Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory or population studies into clinical application to reduce incidence of cancer, morbidity and mortality. It is becoming increasingly evident that cancer is a preventable disease. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention.
  • "Perspectives in Inflammation Biology" outlines detailed studies using preclinical murine models in Inflammation. The book is meant for academicians, industry persons, research scholars and students alike. The detailed perspective for a beginner and the exhaustive methodologies and analyses outlined, for the veteran researcher, makes this book a unique link between someone who is thinking of embarking on a study of inflammation and one who is delving deep into this area of specialization. The book deals with asthma and allergy as specific disease areas of inflammation of the lung, aseptic peritonitis as a disease of systemic inflammation and details how each role player in its pathophysiology has a unique niche of activity. Data acquisition, sequentiality and analyses in context demonstrate how each role player is validated systematically to become a target for drug discovery. Methods and models used in the course of my work and their relevance will demonstrate to the researcher how a study can be developed from an idea. Further into a researcher's ongoing work, this book is meant to stimulate new questions and pave ways for better dissection of a phenomenon. The highlights of this book are the detailed tables tabulating sub species of immune cells, their inflammatory recruitment indices, their translation into tissue-to-tissue traffic of the inflammatory stimulus and the delicate interplay of resident structural cells, cells recruited from circulation, their feedback poiesis in bone marrow, their instruction in the lymphoid organs and tissues as well as the non-cellular mediators synthesized from corresponding genetic instruction. The book shall definitely help students and researchers how a disease can be simplified from its complex ramifications and network of implications and put back into perspective and the whole thing falls into place without an intimate understanding of the mechanism and the compelling circumstances that causes a disease, a drug hunter cannot hope to begin her quest. To find the Achilles heel and effectively neutralize the enemy!
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  • KM and urban health. Knowledge management for the urban health context / M. Chris Gibbons, Rajeev K. Bali, and Nilmini Wickramasinghe -- Healthcare knowledge management : incorporating the tools technologies strategies and process of KM to effect superior healthcare delivery / Nilmini Wickramasinghe -- Knowledge Management in the urban health context : moving towards tacit-to-tacit knowledge transfer / Rajeev K. Bali, Vikram Baskaran, and Raouf N.G. Naguib -- Incorporating KM principles into urban health contexts. A childhood/adolescent knowledge management system for urban area health programs in the District of Columbia / Michael L. Popovich and Xiaohui Zhang -- Urban health in developing countries / Siddharth Agarwal, Aradhana Srivastava, and Sanjeev Kumar -- A pervasive wireless knowledge management solution to address urban health inequalities with indigenous Australians / Nilmini Wickramasinghe, Indrit Troshani, and Steve Goldberg -- The development of a framework to evaluate the management of HIV/AIDS programmes in rural and urban South Africa / Rochelle Sassman ... [et al.] -- The potential of serious games for improving health and reducing urban health inequalities / M. Chris Gibbons -- Measures and metrics for KM and urban health. A scalable and viable strategy for managing organization : typology of intervening into complex healthcare environment for enhancing its continual development / Murako Saito -- Amplifying resonance in organizational learning process : knowledge sharing for overcoming cognitive barriers and for assuring positive action / Murako Saito -- Developing new urban health metrics to reduce the know-do gap in public health / Carlos Castillo-Salgado and Michael Christopher Gibbons -- Recommendations on evaluation and development of useful metrics for urban health / Carlos Castillo-Salgado and M. Chris Gibbons -- Making sense of urban health knowledge / Rajeev K. Bali ... [et al.].
  • A brief history of SHAR -- Structures, mechanisms, and energetics in temporal processing -- Human auditory cortex: in search of the flying Dutchman -- From cajal to the connectome: building a neuroanatomical framework for understanding the auditory system -- Recording from hair cells -- Three decades of tinnitus-related research -- The sense of hearing in fishes -- A quarter-century's perspective on a psychoacoustical approach to loudness -- Nonsyndromic deafness: it ain't necessarily so -- Evolving mechanosensory hair cells to hearing organs by altering genes and their expression: the molecular and cellular basis of inner ear and auditory organ evolution and development -- The implications of discharge regularity: my forty-year peek into the vestibular system -- Aging, hearing loss, and speech recognition: stop shouting, i can't understand you -- Cochlear mechanics, otoacoustic emissions, and medical olivocochlear efferents: twenty years of advances and controversies along the areas ripe for new work -- Examining fish in the sea: a European perspective -- The behavioral study of mammalian hearing -- Hearing in insects: the why, when, and how -- The cognitive auditory system: the role of learning in shaping the biology of the auditory system -- Fundamentals of hearing in amniote vertebrates -- Directional hearing in insects and other small animals: the physics of pressure-difference receiving ears -- Distributed cortical representation of sound locations -- Pitch: mechanisms underlying the pitch of pure and complex tones -- Unavoidably delayed: apersonal perspective of twenty years of research on a sound localization cue -- Size matters in hearing: how the auditory system normalizes the sounds of speech and music for source size -- A changing view of the auditory system obtained from the ears of bats -- From cave fish to pile driving: a tail of fish bioacoustics -- Current topics in the study of sound conduction to the inner ear -- From degenerative debris to neuronal tracing: an anterograde view of auditory circuits -- Adventures in bionic hearing -- My dull deaf ears: four millennia of acquired hearing loss -- What's the use of genetics? -- Advances in the understanding of binaural information processing: consideration of the stimulus as processed -- Temporal processing: observations on the psychophysics and modeling of temporal integration and temporal resolution -- Psychoacoustics and auditory perception -- Appendix. The first 49 volumes.
  • Introduction to a conversation / Jeff Malpas and Norelle Lickiss -- Human dignity and human worth / Daniel P. Sulmasy -- Human dignity and human being / Jeff Malpas -- On human dignity: fragments of an exploration / Norelle Lickiss -- Two conceptions of dignity : honour and self-determination / Andrew Brennan and Y.S. Lo -- Human dignity and charity / Rosalind Hursthouse -- Human dignity: functions and meanings / Doron Shultziner -- A brief history of human dignity: idea and application / Milton Lewis -- A Journey towards understanding: true and false dignity / Christina Mason -- The question of human dignity: doubts and loves and a whisper from where the ruined house once stood / Veronica Brady -- Human dignity: a borderline heretical response / Stuart Blackler -- Giving the past its dignity / Greg Dening -- Dignity and indignity / Nicholas Tarling -- Human dignity and the law / Sir Guy Green -- On the international legal aspects of human dignity / Don Chalmers and Ryuichi Ida -- Doing justice to dignity in the criminal law / Julia Davis -- Human dignity: the new phase in international law / Michael Tate -- Dignity and health / Martin Tattersall -- Human dignity : the perspective of a gynaecological oncologist / Neville F. Hacker -- The social origins of dignity in medical care at the end of life / Nicholas Cristakis -- Dying with dignity : the story reveals its meaning / Jack Coulehan.
  • Overview of healthcare, disease, and disability / Jeffrey Kaye, Tracy Zitzelberger -- Computer science tools and techniques / Martha E. Pollack, Bart Peintner -- Pervasive computing in hospitals / Jakob E. Bardram, Heribert Baldus, Jesus Favela -- Pervasive computing in the home and community / Donald J. Patterson, Henry A. Kautz, Dieter Fox, Lin Liao -- Mobile and personal health and wellness management systems / Elina Mattila, Ilkka Korhonen, Niilo Saranummi -- Sensors and wearable technologies for pervasive healthcare / Sungmee Park, Sundaresan Jayaraman -- Assistive technologies / Edmund LoPresti -- Human factors and usability of healthcare systems / Andre Kushniruk, Elizabeth Borycki -- Routes and requirements for realizing pervasive medical devices / Michael P. Craven -- User evaluation in pervasive healthcare / Tim Adlam, Roger Orpwood, Teresa Dunn -- The business of pervasive healthcare / Dadong Wan, Luis E. Taveras.
  • Between rising costs and decreasing accessibility, the present health care picture is fraught with shortcomings--a discouraging scenario for the millions of patients struggling with chronic diseases such as diabetes and hypertension. In response, computer technology is emerging as a key factor in the transition from inefficient centralized health systems toward patient-centered, patient-involved care: pervasive healthcare. In straightforward fashion, Pervasive Health Knowledge Management systematically explains how mobile technologies and knowledge management (KM) can streamline health systems by removing time and place limitations, reducing costs, and giving patients a more proactive part in managing their conditions. The book defines the role of KM in pervasive healthcare and analyzes its component processes and technologies. Chapters examine how and why KM works, review KM initiatives within and outside the U.S., and offer extended coverage of possibilities for ubiquitous computing in managing diabetes. Together, they outline a future that meets mounting chronic health concerns with efficient, cost-effective, patient-empowering strategies. Highlights of the coverage: Implicit and explicit knowledge assets in healthcare.Using pervasive technologies to manage knowledge in crisis situations.Smart phone application design and knowledge management for people with dementia.A pervasive technology solution for supporting diabetes self-care.Examining the business and IT aspects of wireless enabled healthcare solutions.Developing an internet-based chronic disease self-management system. Healthcare administrators and researchers in healthcare management, health policy, and health services research will find detailed in Pervasive Health Knowledge Management a visionary approach to many of the most pressing problems in their fields.
  • Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.
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  • Pesticide protocols 2005
    Springer Protocols
  • Presenting both oncological and nononcological applications, this book covers the full range of scenarios the clinician is likely to encounter in the professional setting. With a special focus on PET/CT correlation and FDG oncological imaging, this text addresses the important role of PET/CT in managing patients with cancer, Alzheimer.s disease, epilepsy, and other disorders. Each chapter in the Oncological Applications section of the text focuses on a particular disease, allowing the reader to quickly access the information relevant to managing a specific clinical situation. Thorough review of the existing scientific literature and pointers on how to interpret and report images provide readers with the tools to sharpen their assessment and decision-making skills and improve patient care.
  • PET and SPECT in Neurology highlights the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the neurologist and the radiologist/nuclear medicine specialist to the interested general practitioner and geriatrician. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.
  • PET and SPECT of Neurobiological Systems combines the expertise of renowned authors whose dedication to the development of novel probes and techniques for the investigation of neurobiological systems has achieved international recognition. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of (more than 20 different) neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, -amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to anyone in the field of clinical or preclinical neuroscience, from the radiochemist and radiologist/nuclear medicine specialist to the interested neurobiologist and general practitioner. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in "neurology".
  • PET in oncology 2008
  • PET Physics and Instrumentation / Brad Kemp -- PET Radiochemistry and Radiopharmacy / Mark S. Jacobson, Raymond A. Steichen and Patrick J. Peller -- PET/CT Interpretation / Patrick J. Peller -- Central Nervous System / Jeffrey A. Miller and Terence Z. Wong -- Head and Neck / Rathan M. Subramaniam, J. M. Davison, Ujas Parikh and M. Abou-Zied -- Chest / Rathan M. Subramaniam, J. M. Davison, D. S. Surasi, Gregory Russo and P. J. Peller -- Breast Cancer / Gustavo A. Mercier, Felix-Nicolas Roy and François Ba\0302enard -- Gastrointestinal / Roland Hustinx -- Genitourinary / Jacqueline Brunetti and Patrick J. Peller -- Gynecologic / Patrick J. Peller -- Musculoskeletal / Jeffrey J. Peterson -- Hematology / Rathan M. Subramaniam, Leonne Prompers, A. Agarwal, Ali Guermazi and Felix M. Mottaghy -- Dermatological / David Brandon and Bruce Barron -- Pediatric / Hossein Jadvar, Frederic H. Fahey and Barry L. Shulkin -- Assessment of Response to Therapy / Ali Gholamrezanezhad, Alin Chirindel and Rathan Subramaniam -- Metastatic Disease / Patrick J. Peller -- Radiotherapy Planning / Minh Tam Truong and Rathan M. Subramaniam -- Patients with HIV / Rathan M. Subramaniam, J. M. Davison, Devaki S. Surasi, T. Jackson and T. Cooley -- Pitfalls and Artifacts / Geoffrey Bates Johnson and Christopher Harker Hunt.
  • Importance of Radiotracers Other than FDG in Oncology / Luigi Mansi, Pier Francesco Rambaldi and Vincenzo Cuccurullo -- Considerations About PET Isotopes / Luigi Mansi, Vincenzo Cuccurullo and Pier Francesco Rambaldi -- Choline PET-CT / Mohsen Farsad, Vincenzo Allegri and Paolo Castellucci -- Methionine PET-CT / Cristina Nanni, Valentina Ambrosini and Stefano Fanti -- Fluoride PET-CT / Roland Hustinx and Catherine Beckers -- Tyrosine PET-CT / Mohsen Farsad and Gabriele Pöpperl -- Somatostatin Receptor PET-CT / Valentina Ambrosini, Paolo Castellucci, GianCarlo Montini and Stefano Fanti -- Acetate PET-CT / Mohsen Farsad, Franca Chierichetti and Stefano Fanti -- Thymidine PET-CT / Ken Herrmann and Andreas Buck -- Dopa PET-CT / Adrienne H. Brouwers, Klaas P. Koopmans, Rudi A. J. O. Dierckx and Philip H. Elsinga -- Imaging of Hypoxia with PET-CT / Tove J. Grönroos, Heikki Minn and Rodney J. Hicks -- Angiogenesis PET Using Radiolabeled RGD Peptides / Keon Wook Kang, Jae Min Jeong and Ambros J. Beer -- Hormonal Receptors PET-CT / Erik F. J. de Vries, Andor W. J. M. Glaudemans, Caroline P. Schröder and Geke A. P. Hospers -- HTP PET-CT / Adrienne H. Brouwers, Klaas P. Koopmans, Rudi A. J. O. Dierckx and Philip H. Elsinga.
  • PET-CT hybrid imaging 2010
    Thieme Book
    Basic principles -- Imaging of neoplastic diseases -- Inflammatory diseases / M. Luffler and J. Wessling -- Diagnosis of cardiovascular diseases / M. Schaefers and R. Fischbach -- Neurodegenerative diseases / M. Weckesser and T.-U. Niederstadt -- Developments and outlook / O. Schober and W. Heindel.
  • Provides practical, useful information for utilizing this novel imaging techniquefrom different methods for contouring biological target volumes in various anatomic regions to how different experts use this imaging in targeted treatment. This thorough text helps you make concise, accurate treatment choices based on current evidence and expert authority. The result is an helpful tool for everyone on the radiotherapy treatment team in the era of image-guided radiotherapy. Covers the use of PET-CT with radiotherapy treatment planning, offering practical guidance in how different experts use this relatively new technology. Outlines the advantages and disadvantages of different techniques in contouring PET-CT target volumes for radiotherapy. Features case illustrations in using PET-CT in radiotherapy.
  • PET-CT is increasingly being employed in the diagnosis of both oncological and non-oncological patients, yet nuclear medicine physicians may have only limited practical experience of rare diseases and may experience difficulty in recognizing and interpreting rare findings. This unique atlas documents a large number of clinical cases that will help practitioners to identify findings and diseases that, though rare, are sufficiently frequent to be encountered in routine practice. Two types of cases are presented: patients evaluated for rare diseases and patients evaluated for standard diseases in whom atypical PET findings were detected. Each reported case includes a brief description of the clinical history, representative color PET-CT images obtained using FDG or other tracers, and a short explanation of the disease and findings. This atlas will enable practitioners to make conclusive reports of PET-CT scans that would otherwise have been inconclusive.
  • Provides fundamental information to all clinicians interested in incorporating PET into their clinical practice and who are involved in the diagnosis, initial staging, and restaging of malignancy. Covers basic principles such as patient preparation, imaging interpretation, and reimbursement, to specific applications for oncologic, cardiac, and neurologic disorders.
  • PET/MRI is an exciting novel diagnostic imaging modality that combines the precise anatomic and physiologic information provided by magnetic resonance imaging (MRI) with the molecular data obtained with positron emission tomography (PET). PET/MRI offers the promise of a simplified work flow, reduced radiation, whole-body imaging with superior soft tissue contrast, and time of flight physiologic information. It has been described as the pathway to molecular imaging in medicine. In compiling this textbook, the editors have brought together a truly international group of experts in MRI and PET. The book is divided into two parts. The first part covers methodology and equipment and comprises chapters on basic molecular medicine, development of specific contrast agents, MR attenuation and validation, quantitative MRI and PET motion correction, and technical implications for both MRI and PET. The second part of the book focuses on clinical applications in oncology, cardiology, and neurology. Imaging of major neoplasms, including lymphomas and tumors of the breast, prostate, and head and neck, is covered in individual chapters. Further chapters address functional and metabolic cardiovascular examinations and major central nervous system applications such as brain tumors and dementias. Risks, safety aspects, and healthcare costs and impacts are also discussed. This book will be of interest to all radiologists and nuclear medicine physicians who wish to learn more about the latest developments in this important emerging imaging modality and its applications.
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  • 1. Introduction -- 2. Anatomy of the penis, with special attention to the tunica albuginea and to the corpora cavernosa -- 3. Epidemiology -- 4. Aetiology and risk factors -- 5. Nosology -- 6. Natural history of Peyronie's disease -- 7. Experimental models and laboratory research for Peyronie's disease -- 8. Symptoms, their physiopathology, and outpatient clinical practice and diagnosis -- 9. Congenital and acquired penile curvature: relationships and differences -- 10. Psychological aspects of Peyronie's diseaese -- 11. Imaging in Peyronie's disease -- 12. Therapy: a general approach -- 13. Medical therapy -- 14. Combination therapy (in the treatment of Peyronie's disease) -- 15. Surgical therapy for Peyronie's disease: why and when (an overview) --16. Advanced techniques of plication surgery with basal approach: when and why -- 17. Corporoplasty: why and when -- 18. Surgical treatment of Peyronie's disease of inflatable penile prosthesis -- 19. Surgical techniques for difficult and complicated cases of Peyronie's disease -- 20. Future perspectives in Peyronie's Disease.
  • Historical review of Peyronie's disease: de la Peyronie to Devine / Emre Akkus -- Epidemiology of Peyronie's disease / Ates Kadioglu and Oner Sanli -- Experimental models for the study of the cellular and molecular pathophysiology of Peyronie's disease / Nestor F. Gonzalez-Cadavid and Jacob Rajfer -- The clinical implications of basic science research in Peyronie's disease / John P. Mulhall -- Evaluation of the man with Peyronie's disease / Jason M. Greenfield and Laurence A. Levine -- Oral treatment of Peyronie's disease / Claudio Teloken, Tulio Graziottin, and Patrick E. Teloken -- Intralesional treatment of Peyronie's disease / Muammer Kendirci, Landon Trost, and Wayne J. G. Hellstrom -- Topical therapy: iontophoresis and electromotive drug administration / Savino M. Di Stasi ... [et al.] -- Topical therapy for Peyronie's disease: ultrasound, laser, gels/creams/solutions / Paul F. Engelhardt and Claus R. Riedl -- Combination nonsurgical therapy / Vincenzo Mirone -- Extracorporeal shockwave therapy in Peyronie's disease / Ekkehard W. Hauck and Wolfgang Weidner -- The Nesbit and plication procedures for Peyronie's disease / David J. Ralph -- Penile plication using the 16-dot technique / Robert C. Dean and Tom F. Lue -- Penile straightening with tunica albuginea plication: TAP procedure / Laurence A. Levine -- Incisional corporoplasty for the correction of Peyronie's disease caused penile curvature / Daniel Yachia -- Peyronie's disease: surgical straightening with tunica plication and tunica transfer / Konstantinos Hatzimouratidis and Dimitrios G. Hatzichristou -- A review of plaque incision with focus on temporalis fascia grafts / Martin Gelbard -- Venous patch graft surgery for Peyronie's disease / Robert C. Dean and Tom F. Lue -- Use of porcine small intestinal submucosal graft in the surgical management of Peyronie's disease / L. Dean Knoll -- Penile straightening with plaque incision or partial excision and human pericardial grafting technique / Laurence A. Levine -- Surgical straightening with tunica incision and grafting technique: single relaxing incision based on geometrical principles / Paulo H. Egydio -- Minimally invasive intracorporal incision of Peyronie's plaque / Anthony J. Bella and Gerald B. Brock -- Surgical straightening with penile prosthesis / Steven K. Wilson and Culley C. Carson, III.
  • "Pfenninger and Fowler's Procedures for Primary Care, 3rd Edition is a comprehensive, "how-to" resource offering step-by-step strategies for nearly every medical procedure that can be performed in an office, hospital, or emergency care facility by primary care clinicians. Designed for everyday practice, the outline format allows speedy reference while the detailed text and clear illustrations guide you through each procedure. The new edition of this best-selling book features full-color illustrations and easy access to the complete contents and illustrations, patient forms, and more online at "--Publisher's website.
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    Avoiding problems with the phacoemulsification machine / William J. Fishkind -- Gas-forced infusion : the solution for surge / Sunita Agarwal -- Mastering the transition to phacoemulsification : avoiding nightmares / Samuel Boyd, Benjamin F. Boyd, Cristela F. Aleman -- Preventing complications using no anesthesia cataract surgery with the karate chop technique / Amar Agarwal -- Using safe horizontal chopping to prevent ruptures / L. Felipe Vejarano, Alejandro Tello -- Principles and paradigms of pediatric cataracts surgery and intraocular lens implantation / Suresh K. Pandey, M. Edward Wilson -- Subluxated cataracts and endocapsular rings / Athiya Agarwal -- Mature cataracts and dyes / Amar Agarwal -- Small pupil phacoemulsification / Amar Agarwal, Soosan Jacob -- Intraoperative floppy iris syndrome / David F. Chang -- Surgical approach to iris reconstruction for iris diaphragm deficiency or dysfunction / Christopher Khng ... [et al.] -- Posterior polar cataracts / Abhay R. Vasavada, Shetal M. Raj -- Combined cataract and glaucoma surgery / Amar Agarwal, Soosan Jacob -- Phacoemulsification and keratoplasty / Javier Mendicute ... [et al.] -- Bimanual phacoemulsification : surgical technique / Amar Agarwal -- Microphakonit / Amar Agarwal -- Complications of bimanual phacoemulsification / Amar Agarwal, Mahipal Singh Sachdev, Clement K. Chan. Phacoemulsification for hyperopia and nanophthalmos / Amar Agarwal, R. Sujatha -- Cataract surgery in dry eye / Suresh K. Pandey, Brighu Swamy, Amar Agarwal -- Phacoemulsification in patients with uveitis / Jorge L. Alio, Herminio Negri -- Refractive cataract surgery / Pandelis Papadopoulos -- Complications of phacoemulsification / L. Felipe Vejarano, Alejandro Tello -- Iatrogenic descemetorhexis as a complication of phacoemulsification / Amar Agarwal ... [et al.] -- Posterior capsular rupture / L. Felipe Vejarano, Alejandro Tello -- Intraocular Lens Power calculation in complex cases / Benjamin F. Boyd, Samuel Boyd, Luis W. Lu -- Posterior capsule opacification / Suresh K. Pandey ... [et al.] -- Intraocular Lens opacification / Suresh K. Pandey, Liliana Werner, David J. Apple -- Managing dislocated lens fragments / Clement K. Chan -- Surgical management of the malpositioned intraocular implant /Clement K. Chan ... [et al.] -- Infectious endophthalmitis / Clement K. Chan, Steven G. Lin -- Cystoid macular edema / Soosan Jacob, Amar Agarwal --
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  • The pharmaceutical industry needs a shot in the arm - and not a moment too soon. The executive suite is mired in a bygone era, a time when extensive, well-funded pharmaceutical R & D produced blockbuster drugs, kept everything in-house and reaped the financial rewards. But that way of working needs to change. Executives now need to know what the technologists in their companies are doing in order to survive the next decade. Written for those new to industry, as well as for experienced professionals or specialists looking to expand their knowledge, this book is a must-read for business executive.
  • This volume examines the effects of natural products and functional/medical foods (nutritional programming) on disease management. It specifically focuses on diseases related to inflammation and immunity, cancer and cachexia, allergies, and brain and neuro/immune. As both pharmacologists and nutritionists are recognizing that the one disease/one target/one drug (or nutrient) concept will be less successful than in the past, this book aims to stress the importance of a multi-target approach versus a single-target approach. It also presents aspects of molecular characteristics of food ingredients toward clinical effectiveness and relevance. The interest in food in health and disease has exploded in the past few years, and publications on the microbiome can be found in all major scientific journals and newspapers. A new concept uses functional foods hand in hand with standard pharmacological therapies, which can be conceptualized in the term 'pharma-nutrition.' With the complementary values of pharma and nutrition, scientists might be able to overcome the increased incidence worldwide of complex multi-factorial disorders, chronic and degenerative diseases in particular.
  • A Proactive Approach to Improving and Protecting the EnvironmentThe accumulation of pharmaceuticals in the environment is a growing concern, the magnitude of which has not been determined, yet cannot be ignored. Touting the benefits of research and discovery as it relates to a pharmaceutical presence in the environment, Pharmaceutical Accumulation in the Environment: Prevention, Control, Health Effects, and Economic Impact explores ways to effectively minimize the harmful impact of environmental contaminants. It considers current practice in the field, provides a historical reference, and pres.
  • Translational medicine: a paradigm shift in modern drug discovery and development: the role of biomarkers / Mark Day, J. Lynn Rutkowski, and Giora Z. Feuerstein -- Natural products in drug discovery: present status and perspectives / Gabriella Molinari -- Protein pharmaceuticals: discovery and preclinical development / Davinder S. Gill -- The role of nanobiotechnology in drug discovery / Kewal K. Jain -- Conotoxin venom peptide therapeutics / Richard J. Lewis -- Shark novel antigen receptors: the next generation of biologic therapeutics? / Caroline Barelle, Davinder Gill, and Keith Charlton -- Immune interventions of human diseases through toll-like receptors / Cevayir Coban, Ken J. Ishii, and Shizuo Akira -- Genome-based vaccine development: a short cut for the future / Danilo Gomes Moriel ... [et al.] -- The antigenome: from protein subunit vaccines to antibody treatments of bacterial infections? / Carmen Giefing, Eszter Nagy, and Alexander von Gabain -- HSV as a vector in vaccine development and gene therapy / Peggy Marconi ... [et al.] -- Virus-like particles as a vaccine delivery system: myths and facts / Polly Roy and Rob Noad -- Applications of bacterial ghosts in biomedicine / Petra Lubitz, Ulrike Beate Mayr, and Werner Lubitz -- Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design / Thomas Ebensen and Carlos A. Guzmøn -- Innovative approaches to develop prophylactic and therapeutic vaccines against HIV/AIDS / Aurelio Cafaro ... [et al.] -- New strategies to overcome the drawbacks of currently available flu vaccines / Epifanio Fichera ... [et al.].
  • Introduction to Competitive Intelligence -- Overall Perspective of Due Diligence Investigations and Processes -- The Regulatory Functional Review: Primary Roles -- The On-Site Due Diligence/Data Room Meeting and Interactions with Other Functional Area Experts -- Intellectual Property -- The Final Report -- Competitive Intelligence Summary.
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  • Introduction to experimental design -- Comparison of mean values -- Nonparametric methods -- Regression and correlation -- Multivariate methods -- Factorial design of experiments -- Response-surface methodology -- Model-dependent optimization -- Sequential methods and model-independent optimization -- Experimental designs for mixtures -- Artificial neural networks and experimental design.
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    Strategic project management at the project level / Tony Kennedy -- Strategic project management at the portfolio level / Kevin Bilyard and Des Markland -- Project planning : from basic concepts to systems application / Carl A. Kutzbach, Carole Strong, and Sylvia Walker -- Project management of chemical, analytical, and formulation development / Dieter Krimmer -- Project management in exclusive synthesis / Lukas M.J. von Hippel -- Clinical trials--can they be project managed? / Les Rose -- Regulatory project management / Nicholas Wells -- Teams / Ralph White -- Project management and outsourcing drug development / Jon Court and Mark Fowler -- The project management function / Tony Kennedy.
  • 1. Overview of Medicines Regulatory Systems in the Gulf Region -- 2. The Regulatory Review Process in the Gulf Region -- 3. Regulatory Review Times in the Gulf Region -- 4. Quality Measures in the Gulf Regulatory Practices -- 5. The Current Status of the Common Technical Document -- 6. The Current Status of Drug Safety and Pharmacovigilance -- 7. The Centralized Regulatory Review in the Gulf Region -- 8. The Gulf States Assessment and Experience With the Centralised Procedure -- 9. The Pharmaceutical Companies Assessment and Experience With the Centralised Procedure -- 10. Proposal For an Improved Centralized Regulatory System -- 11. The Strategic Planning Process of the GCC Regulatory Authorities: Barriers And Solutions -- 12. The Regulatory Dilemma in the Gulf Region: The Way Forward.
  • Contains proceedings of the AAPS Stability Workshop.
  • 2007 ProQuest Safari
    Statistics in drug development by Christy Chuang-Stein and Ralph D'Agostino -- Modern classification methods for drug discovery by Kjell Johnson and William Rayens -- Model building techniques in drug discovery by Kimberly Crimin and Thomas Vidmar -- Statistical considerations in analytical method validation by Bruno Boulanger, Viswanath Devanaryan, Walthère Dewé, and Wendell Smith -- Some statistical considerations in nonclinical safety assessment by Wherly Hoffman, Cindy Lee, Alan Chiang, Kevin Guo, and Daniel Ness -- Nonparametric methods in pharmaceutical statistics by Paul Juneau -- Optimal design of experiments in pharmaceutical applications by Valerii Fedorov, Robert Gagnon, Sergei Leonov, and Yuehui Wu -- Analysis of human pharmacokinetic data by Scott Patterson and Brian Smith -- Allocation in randomized clinical trials by Olga Kuznetsova and Anastasia Ivanova -- Sample-size analysis for traditional hypothesis testing: concepts and issues by Ralph G. O'Brien and John Castelloe -- Design and analysis of dose-ranging clinical studies by Alex Dmitrienko, Kathleen Fritsch, Janson Hsu, and Stephen Ruberg -- Analysis of incomplete data by Geert Molenberghs, Caroline Beunckens, Herbert Thijs, Ivy Jansen, Geert Verbeke, Michael Kenward, and Kristen Van Steen -- Reliability and validity: Assessing the psychometric properties of rating scales by Douglas Faries and Ilker Yalcin -- Decision analysis in drug development by Carl-Fredrik Burman, Andy Grieve, and Stephen Senn.
  • Advances in drugs and biologics to mitigate or cure some of nature's most complex medical problems have been incredible to behold. These accomplishments are due to the actions of a wide theatre of participants from biologists, pharmacologists, geneticists, chemists and manufacturers, molecular biologists, toxicologists, clinicians, nurses, program managers, quality assurance personnel, regulatory professionals and a new group of innovators the Imaging Scientists. Imaging has grown from the microscopy sections put on slides with special stains to now in vivo slices created with innovative physics, imaging tracers and contrast agents, and incredibly fast and accurate computational systems. The world of biology has become one of witnessing the actions of drugs and biologics through the window of mechanical and electrical engineering creating instruments and reporter molecules that can help us see into our bodies and paint them with medical information needed to resolve disease. This book will inspire imagination and elicit even more innovations in the development of new and novel drugs and biologics through imaging.
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  • Principles of Cancer Treatment / William G. Newman and Fiona H. Blackhall -- Clinical Pharmacology and Anticancer Drugs / Cristina Rodríguez-Antona and Julia Kirchheiner -- Principles of Genetics and Pharmacogenetics / William G. Newman -- Pharmacogenetics in the Management of Breast Cancer / Sacha J. Howell -- Pharmacogenetics in Colorectal Cancer / Roberta Ferraldeschi -- Pharmacogenetics in Lung Cancer / Fiona Blackhall -- Pharmacogenetics and Cancer Treatment in Children / P. Kellie Turner and Gareth J. Veal -- Pharmacogenetics in Palliative Care / Andrew A. Somogyi -- Genetic Predictors of Normal Tissue Response to Radiotherapy / Catharine M.L. West, Gillian C. Barnett, Alison M. Dunning, Rebecca M. Elliott and Neil G. Burnet -- Cancer Pharmacogenetics in Industry / Mireille Cantarini -- Ethical Issues in Pharmacogenetics / Tara Clancy -- Economics of Cancer Pharmacogenetics / Katherine Payne -- Future Advances in Cancer Pharmacogenomics / William G. Newman.
  • Challenges, opportunities, and evolving landscapes in pharmacogenomics and personalized medicine : an industry perspective / Nadine Cohen and Theresa Frangiosa -- Implementation of pharmacogenomic sample collection in clinical trials / Deborah Sokol Ricci and Monique Franc -- Pharmacogenomics : the regulatory environment and labeling implications / Myong-Jin Kim ... [et al.] -- Applications of pharmacogenomics in drug discovery / Duncan McHale -- Applications of pharmacogenomics in clinical trials / Monique Franc -- Pharmacogenomics applications in drug metabolism : from genotyping to drug label-challenges? / Ann K. Daly -- The genetics of adverse drug reactions : promises and problems / Martin Armstrong -- Strategies and resources for marker selection and genotyping in genetic association studies / Nicole Soranzo, Dong-Jing Fu, and Qingqin S. Li -- Study design and statistical issues in pharmacogenetics research : from candidate genes to genome-wide screens / Nicholas J. Schork, Nathalie Malo, and Eric J. Topol -- Holy SNP, Batman! / Reyna Favis -- Predictive biomarker classifiers in the design of pivotal clinical trials / Richard Simon -- Translation of biomarkers into clinical utility / William L. Trepicchio and George Mulligan -- Pharmacogenomic study feasibility assessment and pharmaceutical business decision-making / Monique Franc and Theresa Frangiosa -- Co-development of drugs and pharmacogenomics-based diagnostics in oncology / Jeffrey S. Ross -- Pharmacogenomics applications in epilepsy / Chantal Depondt -- Pharmacogenomics in Alzheimer's disease / Ramón Cacabelos -- Pharmacogenomics applications in psychiatric disorders / Todd Lencz and Anil K. Malhotra -- Pharmacogenomics in HIV disease / Amalio Telenti -- Pharmacogenomics and cardiovascular drugs / Gérard Siest ... [et al.] -- Pharmacogenomic applications in children / Susan F.A. Grant and Hakon Hakonarson -- Pharmacogenomics of rare and monogenic disorders / Paul D. Maher.
  • Pharmacogenomics principles : introduction to personalized medicine / Parvaz Madadi, and Gideon Koren -- Traditional therapeutic drug monitoring and pharmacogenomics : are they complementary? / Christine Snozek, Loralie J. Langman, and Amitava Dasgupta -- Pharmacogenomics aspect of warfarin therapy / Matthew D. Krasowski -- Pharmacogenetics and cancer chemotherapy / Christine L.H. Snozek -- Pharmacogenomic considerations in anesthesia and pain management / Christine Formea, Wayne T. Nicholson -- Pharmacogenomics of immunosuppressants / Nicolas Picard and Pierre Marquet -- Pharmacogenomics of cardiovascular drugs / Linnea M. Baudhuin -- Pharmacogenomics aspect of antiretroviral therapy / Natella Y. Rakhmanina and John N. van den Anker -- Pharmacogenetics of psychoactive drugs / Jorge L. Sepulveda -- Pharmacogenomic aspects of adverse drug-drug interactions / Loralie J. Langman and Christine Snozek -- Microarray technology and other methods in pharmacogenomics testing / Jorge L. Sepulveda -- Pharmacogenetic testing in the clinical laboratory environment / Mark P. Borgman and Mark W. Linder.
  • One tablet or two? : towards the development of pharmacogenomically informed drug dose individualization / Kirchheiner, J. ... [et al.] -- Pharmacogenomics : reflecting on the old and new social, ethical and policy issues in postgenomics medicine / Ozdemir, V. -- Pharmacogenomics and personality : role of CYP2D6 and implications for psychopathology / Peñas-LLedó, E.M.; Dorado, P.; Llerena, A. -- Pharmacogenetics of schizophrenia : bringing 'order to chaos' in the psychopharmacology of schizophrenia? / Buckley, P.F.; Miller, D.D.; Foster, A. -- Pharmacogenomics of depression / Serretti, A.; Drago, A.; Spina, E. -- Pharmacogenomics of attention-deficit/hyperactivity disorder / Froehlich, T.; Stein, M.A. -- Pharmacogenomics of eating disorders / Monteleone, P.; Maj, M. -- Future of personalized prescription in psychiatry / de Leon, J.
  • Pharmacogenomics : historical perspective and current status / Rosane Charlab and Lei Zhang -- Denaturing high-performance liquid chromatography for mutation detection and genotyping / Donna Lee Fackenthal [and others] -- Clinical SNP detection by the smartAmp method / Toshihisa Ishikawa and Yoshihide Hayashizaki -- MALDI-TOF mass spectrometry / Dirk van den Boom, Matthias Wjst, and Robin E. Everts -- TaqMan® drug metabolism genotyping assays for the detection of human polymorphisms involved in drug metabolism / Toinette Hartshorne -- Pyrosequencing of clinically relevant polymorphisms / Cristi R. King and Sharon Marsh -- Pharmacogenetics using Luminex® xMAP® technology : a method for developing a custom multiplex single nucleotide polymorphism mutation assay / Gonnie Spierings and Sherry A. Dunbar -- Use of linkage analysis, genome-eide association studies, and next-generation sequencing in the identification of disease-causing mutations / Eric Londin [and others] -- GoldenGate genotyping assay : custom design, processing, and data analysis / Anna González-Neira -- Genome-wide gene expression profiling, genotyping, and copy number analyses of acute myeloid leukemia using affymetrix geneChips. / Mathijs A. Sanders and Peter J.M. Valk -- Epigenetic techniques in pharmacogenetics / Sandra G. Heil -- Plasmid derived external quality controls for genetic testing / Tahar van der Straaten and Henk-Jan Guchelaar -- Allelic imbalance assays to quantify allele-specific gene expression and transcription factor binding / Francesca Luca and Anna Di Rienzo -- SCAN : a systems biology approach to pharmacogenomic discovery / Eric R. Gamazon, R. Stephanie Huang, and Nancy J. Cox -- Methods to examine the impact of nonsynonymous SNPs on protein degradation and function of human ABC transporter / Toshihisa Ishikawa, Kanako Wakabayashi-Nakao, and Hiroshi Nakagawa -- In vitro identification of cytochrome P450 enzymes responsible for drug metabolism / Zhengyin Yan and Gary W. Caldwell -- In vitro and in vivo mouse models for pharmacogenetic studies / Amber Frick [and others] -- Hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers / Mee J. Kim and Nadav Ahituv -- Guide to the current web-based resources in pharmacogenomics / Dylan M. Glubb [and others] -- PharmGKB : the pharmacogenomics knowledge base / Caroline F. Thorn, Teri E. Klein, and Russ B. Altman -- Genetic databases in pharmacogenomics : the frequency of inherited disorders database (FINDbase) / Marianthi Georgitsi and George P. Patrinos -- Development of predictive models for estimating warfarin maintenance dose based on genetic and clinical factors / Lu Yang and Mark W. Linder -- Evidence based drug dosing and pharmacotherapeutic recommendations per genotype / Vera H.M. Deneer and Ron H.N. van Schaik.
  • Ch. 1. Pharmacogenomics principles of alcohol and DOA / Christine L.H. Snozek and Loralie J. Langman -- ch. 2. Alcohol : use and abuse / Amitava Dasgupta -- ch. 3. Slate and trait makers of alcohol abuse / Joshua Bornhorst ... [et al.] -- ch. 4. Introduction to drugs of abuse / Larry Broussard and Catherine Hammett-Stabler -- ch. 5. Pharmacogenomics of amphetamine and related drugs / Steven C. Kazmierczak -- ch. 6. Pharmacogenomics of cocaine / Loralie J. Langman and Christine L.H. Snozek -- ch. 7. Genetic aspect of marijuana metabolism and abuse / Pradip Datta -- ch. 8. Genetic aspect of opiate metabolism and addiction / Jorge L. Sepulveda -- ch. 9. Pharmacogenomics aspects of addiction treatment / F. Gerard Moeller -- ch. 10. Methodologies in pharmacogenetics testing / Jorge L. Sepulveda.
  • Historical aspects of pharmacogenetics / Werner Kalow -- Pharmacogenomics and the promise of personalized medicine / Vural Ozdemir and Bernard Lerer -- Pharmacogenetics of drug metabolism: two clinically important polymorphic enzymes, CYP2D6 and TPMT / Georgios Panagiotidis and Leif Bertilsson -- Receptors / Wendell W. Weber -- Pharmacogenetics of drug transporters / Catia Marzolini, Rommel G. Tirona, and Richard B. Kim -- Variability in induction of human drug metabolizing enzymes / Allan B. Okey -- Pharmacogenetics and cardiac ion channels / Dan M. Roden -- Interethnic differences in drug response / Werner Kalow -- Clinical perspectives / Urs A. Meyer and David A. Flockhart -- Regulatory perspectives on pharmacogenomics / Lawrence J. Lesko and Janet Woodcock -- Tools of the trade: the technologies and challenges of pharmacogenetics / Glenn A. Miller -- Technologies for the analysis of single nucleotide polymorphisms - an overview / Denis M. Grant -- Molecular diagnostics / Tracy L. Stockley and Peter N. Ray --
  • ch. 1. Physicochemistry -- ch. 2. Pharmacokinetics -- ch. 3. Absorption -- ch. 4. Distribution -- ch. 5. Clearance -- ch. 6 Renal clearance -- ch. 7. Metabolic (hepatic) clearance -- ch. 8. Toxicity -- ch. 9. Inter-species -- ch. 10. High(er) throughput ADME studies.
  • SECTION I. Basic Principles -- Chapter 1. Basic Principles / Ronald D. Schoenwald -- SECTION II. Industrial and Regulatory Applications -- Chapter 2. PK/PD Approach / Honghui Zhou -- Chapter 3. Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development / Nishit B. Modi -- Chapter 4. Phase I, II, and III FDA Submissions / Mark G. Eller -- Chapter 5. Bioavailability and Bioequivalence / Veneeta Tandon -- SECTION III. Clinical Applications -- Chapter 6. General Approaches to Clinical Pharmacokinetic Monitoring / Ronald A. Herman -- Chapter 7. Aminoglycosides and Other Antibiotics / Michael E. Klepser and Erika J. Ernst -- Chapter 8. Cardiovascular Agents / John M. Dopp and Bradley G. Phillips -- Chapter 9. Psychotropic Agents / Paul J. Perry -- Chapter 10. Theophylline / Bernd Meibohm -- Chapter 11. Anticonvulsant Agents / Gail D. Anderson -- SECTION IV. Research Applications -- Chapter 12. Classical Modeling / David W A. Bourne -- Chapter 13. Noncompartmental Modeling: An Overview / Ronald A. Herman -- Chapter 14. Physiologically Based Pharmacokinetic Models / James M. Gallo -- Chapter 15. Population Pharmacokinetics / Jeffrey S. Barrett -- Chapter 16. The Linear Systems Approach / Peter Veng-Pedersen -- Index.
  • What next in colorectal cancer? / James Cassidy -- Pathophysiology and drug targets in metastatic colorectal cancer / Autumn McRee & Howard L. McLeod -- First-line chemotherapy / Yoko Yanagisawa, Rachel Midgley & David Kerr -- Monoclonal antibodies / Giuseppe Tonini, Marco Imperatori, Alice Zoccoli, Michele Iuliani & Francesco Pantano -- Drugs in clinical trials / Irene Braña, Rodrigo Dienstmann, Jaume Capdevila & Josep Tabernero -- Which therapy for which patient? / Patryk Kambakamba, Stefan Breitenstein, Panagiotis Samaras, Paul Magnus Schneider & Georg Lurje.
  • This book is the 4th in a series of Acute Care books written with the aim to address the NEEDS of health care providers when handling the acutely ill patients. Globally it has become apparent that the study of pharmacology and subsequent clinical training has not always adequately equipped young doctors with the ability to administer drugs to their patients safely and confidently, particularly in the critically ill patient. Compounding this issue is the lack of resource material related to these pharmacological concepts contained in one book that can help health care providers to understand and manage drug therapy in the acute situation. In spite of progressively newer and more developed protocols, guidelines, algorithms and many other books addressing the technical aspects of what needs to be done, most health care providers still find it difficult to grasp the basic pharmacological knowledge and rationally deliver the CARE that is required in the acute phase of patient management. The editors/authors have therefore aimed for a book that highlights topics and pharmacological issues pertinent to management of patients in their hour of need. This is a multi-author book but the style has been guided by 3 editors. The editors have used a different perspective? that of normalizing abnormal physiological processes with pharmacological agents? to address the GAPS in a bedside to bench approach. The details are pared down but important principles/concepts are emphasized.
  • The natural world with a large number of terrestrial and marine plants and lower organisms is a great source of bioactive compounds historically used as remedies in various diseases. Within the last decade, such compounds became more attractive targets for pharmacologists and the pharmaceutical industry in drug development projects. This volume presents the pharmacological potential of chemically defined natural compounds obtained from plants, fungi, algae and cyanobacteria with antiparasitic activity, that have been tested against various endo-parasitic protozoan and helminth species. --Source other than Library of Congress.
  • Cardiovascular pharmacotherapy is a fast-moving and complex discipline within cardiology in general. New studies, trials and indications are appearing on a regular basis. This series, and this particular title within the series, is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis. The information within is designed to allow readers to learn quickly and with certainty the mode of action, the possible adverse effects, and the management of patients prescribed these drugs.
  • This book describes the clinical challenge currently posed by stable angina pectoris and provides guidance for those making clinical decisions regarding its pharmacological treatment. The importance of providing effective treatment is beyond dispute and this book deals with the most relevant aspects related to its pharmacological treatment. The pathogenesis of myocardial ischemia as the basis for rational treatment of angina is discussed thoroughly together with all major management goals including optimal symptom control and the secondary prevention of serious cardiovascular events. Pharmacological Treatment of Chronic Stable Angina Pectoris provides a clear description of the mechanisms of action and clinical indications of available anti-angina drugs and strategies for the use of novel pharmacological agents. It also includes a critical appraisal of the major management guidelines, which will assist the reader to interpret current evidence and provide the most appropriate forms of treatment. The ongoing controversy regarding medical therapy versus myocardial revascularization for the management of stable angina pectoris is also addressed. This eminently practical book will help guiding the reader through the complexities of the field and will be highly appreciated by clinicians, clinical cardiologists and cardiology trainees alike.
  • Pharmacological treatments in schizophrenia / Matcheri S. Keshavan -- Pathophysiology of psychotic disorders and the need for novel therapeutic targets / Matcheri S. Keshavan -- Current standard treatments / Joseph McEvoy -- Unmet medical needs in schizophrenia treatments / Mujeeb U. Shad -- Novel approaches for treating schizophrenia / Michael C. Davis & Stephen R. Marder -- Novel long-acting and extended-release formulations of antipsychotic drugs / Larry Alphs -- Future directions in the treatment of schizophrenia / Rajiv Tandon -- Index.
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    Pharmacokinetics and pharmacodynamics of injected and inhaled drugs -- Inhaled anesthetics -- Opioid agonists and antagonists -- Barbiturates -- Benzodiazepines -- Nonbarbiturate intravenous anesthetic drugs -- Local anesthetics -- Neuromuscular-blocking drugs -- Anticholinesterase drugs and cholinergic agonists -- Anticholinergic drugs -- Cyclooxygenase-2 inhibitors and nonspecific nonsteroidal antiinflammatory drugs -- Sympathomimetics -- Digitalis and related drugs -- Alpha- and beta-adrenergic receptor antagonists -- Antihypertensive drugs -- Peripheral vasodilators, nitric oxide, and nitrovasodilators -- Cardiac antidysrhythmic drugs -- Calcium-channel blockers -- Drugs used for psychopharmacologic therapy -- Prostaglandins -- Histamine and histamine receptor-antagonists -- Serotonin, plasma kinins, and renin -- Hormones as drugs -- Insulin and oral hypoglycemics -- Diuretics -- Antacids and gastrointestinal prokinetics -- Anticoagulants -- Antimicrobials -- Chemotherapeutic drugs -- Antiepileptic drugs -- Antiepileptic drugs -- Drugs used for treatment of parkinson disease -- Drug treatment of lipid disorders -- Central nervous system stimulants and muscle relaxants -- Vitamins, dietary supplements, and herbal remedies -- Minerals and electrolytes -- Blood components, substitutes and hemostatic drugs -- Enteral and parenteral nutrition -- Antiseptics and disinfectants -- Cell structure and function -- Body fluids -- Central nervous system -- Thermoregulation -- Autonomic nervous system -- Pain -- Systemic circulation -- Microcirculation and lymphatics -- Pulmonary circulation -- Heart -- The electrocardiogram and analysis of cardiac dysrhythmias -- The lungs -- Pulmonary gas exchange and blood transport of gases -- Acid-base balance -- Endocrine system -- Kidneys -- Liver and gastrointestinal tract -- Skeletal and smooth muscle -- Erythrocytes and leukocytes -- Hemostasis and blood coagulation -- Metabolism of nutrients -- Physiology of the newborn and elderly.
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  • Pharmacology -- Pharmacokinetic Principles -- Introduction to Specialist Therapeutics.
  • 2013 ClinicalKey
    "Better understand the complexities of pharmacology and physiology relevant to your practice with the brand-new medical reference book, Anesthetic Pharmacology and Physiology. Drs. Hugh Hemmings and Talmage Egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes. Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs. Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout. Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas"--Provided by publisher.
  • Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. This multimedia resource fills a critical need for a more clinically focused, user-friendly pharmacology reference. Evidence-based therapeutic guidelines facilitate decision making; and coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine keeps you at the forefront of the latest developments.
  • The double page spreads in this book each cover a discrete topic and broadly correspond to the chapters of the main textbook 'Pharmacology' by Rang et al. Each spread includes at least one summary diagram and a small amount of text plus a 'clinical use' box.
  • Chapter 1. Pharmacology: The Chemical Control of Physiology -- Chapter 2. Drug Affinity and Efficacy -- Chapter 3. Predicting Agonist Effect -- Chapter 4. Drug Antagonism: Orthosteric Drug Effects -- Chapter 5. Allosteric Drug Effects -- Chapter 6. Enzymes as Drug Targets -- Chapter 7. Pharmacokinetics I: Permeation and Metabolism -- Chapter 8. Pharmacokinetics II: Distribution and Multiple Dosing -- Chapter 9. In Vivo Pharmacology -- Chapter 10. Safety Pharmacology -- Chapter 11. Answers to Chapter Questions -- Chapter 12. Derivations and Proofs.
  • "This work is the first monograph devoted solely to Bombax ceiba, popularly known as the Red Silk Cotton Tree. Consisting of seven chapters, it covers all relevant aspects of this plant, from its historical and spiritual importance, to its botanical characterization, pharmacognostical details and ethnobiological uses, to its scientific validation in various animal and human studies. Each part of the tree is of medicinal value and possesses many novel chemical constituents such as shamimicin, bombasin, bombamalone, bombamaloside etc. along with other bioactive secondary metabolites. The book presents the chemical structures of the most important constituents and highlights various pharmacological activities, predominantly antioxidant, anti-inflammatory, anti-mutagenic, hypoglycemic, hypotensive, hepatoprotective and fibrinolytic, which may prove to be a source for the development of a novel phyto-pharmaceutical agent to treat diabetes, heart disease and cancer. In addition, separate chapters deal with the commercial and ecological significance of B. ceiba, as well as a case study on its conservation. Numerous color illustrations are included to identify the plant and to justify its nickname, the “Little Bird's Cafeteria”."--Publisher's website.
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    General principles -- The peripheral nervous systems: autonomic and somatic -- The central nervous system -- The cardiovascular system -- The renal system and diuretics -- The respiratory system: asthma and COPD -- Local control substances: autacoids and drugs for inflammatory processes -- The gastrointestinal system and nutrition -- The endocrine system, uterine stimulants, and relaxants -- Anti-infectives -- Cancer chemotherapy and immunosuppressants -- Toxicology.
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    General Principles of Pharmacology -- The Peripheral Nervous System: Autonomic and Somatic Nervous System Pharmacology -- Central Nervous System Pharmacology -- Cardiovascular Pharmacology -- Renal System and Diuretics Pharmacology -- Respiratory System Pharmacology: Asthma and COPD -- Autacoids and Anti-Inflammatory Pharmacology -- Gastrointestinal and Urinary Tract Pharmacology, Nutrition (Vitamins) -- Endocrine Pharmacology, Uterine Stimulants and Relaxants -- Antimicrobial and Antiviral Pharmacology -- Cancer and Immune System Pharmacology -- Toxicology, Bioterrorism, and Chemical Warfare Agents.
  • What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.
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    Adverse drug reaction icons -- Pharmacology basics -- Antimicrobial drugs -- Autonomic drugs -- Cancer chemotherapeutics -- Cardiovascular drugs -- Central nervous system drugs -- Endocrine drugs -- Gastrointestinal drugs -- Hematological drugs -- Immune response modifiers -- Renal and urological drugs -- Respiratory drugs -- Appendix A. Tricks for remembering drug names.
  • "Pharmacology: An Illustrated Review covers the facts and concepts you must master for classroom and USMLE success--as well as key knowledge for daily clinical practice. Thieme's new illustrated Review Series serves an important dual purpose for medical students--both concise course review and high-yield USMLE test preparation. Covering all the basic science subjects that you will take in medical school and that will be found on the USMLE Step 1, the series features unparalleled color illustrations, a streamlined format, and hundreds of print and online study questions and answers--all designed to increase your mastery of the topic, promote classroom success, and boost your confidence for the exam! Combining targeted reviews of the basic sciences with a multitude of exam questions for easy reinforcement and retention, these efficient-to-study books put success at your fingertips"--Provided by publisher.
  • Pharmacology. 4th ed. 2013
    Pharmacology, 4th Edition helps you master the "must-know" concepts in this subject and how they apply to everyday clinical problem solving and decision making. This concise yet comprehensive text clearly explains and illustrates challenging concepts and helps you retain the material - from course exams and the USMLE Step 1 right through to clinical practice. Quickly reference essential information thanks to abundant tables throughout, and drug classification boxes at the beginning of each chapter. See how pharmacology applies to practice with real-world case studies. Prepare for exams with self-assessment questions at the end of each chapter. Understand complex concepts visually with the aid of superb full-color illustrations. Access the complete contents online at, along with an additional glossary, chapter-by-chapter summaries and case studies, a full list of featured drugs, 150 USMLE-style questions, animations, and more.
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  • Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.
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  • This book is driven by the considerable progress made by novel imaging techniques in understanding the pathophysiology and evolution of aortic disease and its diagnosis. Despite the lack of symptoms in stable conditions, most aortic diseases have a high morbidity and mortality. New therapeutic strategies such as endovascular treatment and surgical techniques have appeared to improve conventional surgery in advanced phases of the disease, but until recently, medical treatment has focused on the control of cardiovascular risk factors using beta-blockers to reduce aortic wall stress by reducing blood pressure and heart rate. Pharmacotherapy in Aortic Disease updates the reader on the new medical treatment that are changing the natural history of these diseases. Leading experts have created a critical in-depth, yet concise, analysis of the available medical treatments for different aortic disease entities. Both basic research studies and clinical trials discussed in this book serve as a base for improving therapeutic management, delaying the need for surgery, and prolonging survival in these patients.
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  • Pharmacoepidemiology of diabetes -- New definitions of diabetes: consequences -- The insulin resistance syndrome: concept and therapeutic approaches -- Medical emergencies-diabetic ketoacidosis and hyperosmolar hyperglycaemia -- Notes on the use of glucagon in type 1 diabetes -- Insulin and new insulin analogues, insulin pumps and inhaled insulin in type 1 diabetes -- Insulin and new insulin analogues with focus on type 2 diabetes -- The place of insulin secretagogues in the treatment of type 2 diabetes in the twenty-first century -- Metformin-from devil to angel -- The glitazones, lessons so far -- Antidiabetic combination therapy -- The incretin modulators-incretin mimetics (GLP-1 receptor agonists) and incretin enhancers (DPP-4 inhibitors) -- The role of alpha-glucosidase inhibitors (acarbose) -- Multifactorial intervention in type 2 diabetes -- Obesity and pharmacological treatment -- Management of diabetic dyslipidaemia -- Coronary intervention and ischemic cardioprotection in diabetic patients -- ACE-I and ARB and blood pressure lowering, including effect on renal disease. Treatment of advanced diabetic renal disease -- Aspirin and antiplatelet drugs in the prevention of cardiovascular complications of diabetes -- Glycosylation inhibitors, PKC inhibitors and related interventions against complications -- Diabetic foot ulcers -- Pharmacotherapy in diabetic neuropathy -- Pregnancy-pharmacological problems - Pharmacotherapy of diabetic retinopathy -- Pharmacotherapy in diabetic sexual dysfunction -- A bone perspective -- Achieving guideline control with new pharmacotherapies; albumin-binding by acylation of insulin and GLP-1 -- Pharmacotherapy of diabetes.
  • Definition and classification of pulmonary hypertension / Marc Humbert, David Montani, Oleg V. Evgenov, and Gérald Simonneau -- Pulmonary hypertension: pathophysiology and signaling pathways / Bradley A. Maron and Joseph Loscalzo -- Pulmonary hypertension: pathology / Peter Dorfmüller -- Pulmonary hypertension: biomarkers / Christopher J. Rhodes, John Wharton, and Martin R. Wilkins -- Rodent models of group 1 pulmonary hypertension / John J. Ryan, Glenn Marsboom, and Stephen L. Archer -- General supportive care / Ioana R. Preston -- Calcium-channel blockers in pulmonary arterial hypertension / Marie-Camille Chaumais, Elise Artaud Macari, and Olivier Sitbon -- Prostacyclins / Horst Olschewski -- Endothelin Receptor Antagonists / Martine Clozel, Alessandro Maresta, and Marc Humbert -- Phosphodiesterase-5 inhibitors / Barbara A. Cockrill and Aaron B. Waxman -- Inhaled nitric oxide for the treatment of pulmonary arterial hypertension / Steven H. Abman -- Soluble guanylate cyclase stimulators in pulmonary hypertension / Johannes-Peter Stasch and Oleg V. Evgenov -- Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction / Michael G. Risbano and Mark T. Gladwin -- Rho-kinase inhibitors / Yoshihiro Fukumoto and Hiroaki Shimokawa -- Serotonin transporter and serotonin receptors / Serge Adnot, Amal Houssaini, Shariq Abid, Elisabeth Marcos, and Valérie Amsellem -- Targeting of platelet-derived growth factor signaling in pulmonary arterial hypertension / Eva Berghausen, Henrik ten Freyhaus, and Stephan Rosenkranz -- Emerging molecular targets for anti-proliferative strategies in pulmonary arterial hypertension / Ly Tu and Christophe Guignabert -- Anti-inflammatory and immunosuppressive agents in PAH / Jolyane Meloche, Sébastien Renard, Steeve Provencher, and Sébastien Bonnet -- Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application / Reshma S. Baliga, Raymond J. MacAllister, and Adrian J. Hobbs -- Pulmonary hypertension: novel pathways and emerging therapies inhibitors of cGMP and cAMP metabolism / Yassine Sassi and Jean-Sébastien Hulot -- Pulmonary hypertension: old targets revisited (statins, PPARs, beta-blockers) / Geoffrey Watson, Eduardo Oliver, Lan Zhao, and Martin R. Wilkins -- Pulmonary hypertension: current management and future directions / Lewis J. Rubin.
  • Pharmacy Practice Research- Evidence and Impact -- Research Methodologies related to pharmacy practice: An Overview -- Quantitative Methods in Pharmacy Practice Research -- Qualitative Methods in Pharmacy Practice Research -- Action Research in Pharmacy Practice -- Participatory Action Research in Pharmacy Practice -- Mixed Methods Research in Pharmacy Practice -- Applying organizational theory in Pharmacy Practice Research -- Applying pharmacoeconomic methods in community and hospital pharmacy research -- Concept Mapping and pattern matching in pharmacy practice research -- Pharmacoepidemiological approaches in healthcare -- Future of Pharmacy Practice Research -- Pharmacists' attitudes towards pharmacy practice research: a review.
  • pt. 1. Foundations of phase response analysis -- pt. 2. Estimation of phase response curves -- pt. 3. Cellular mechanisms of neuronal phase response properties -- pt. 4. Prediction of network activity with phase response curves.
  • Learn the most up-to-date information on materials used in the dental office and laboratory today. Emphasizing practical, clinical use, as well as the physical, chemical, and biological properties of materials, this leading reference helps you stay current in this very important area of dentistry. This new full-color edition also features an extensive collection of new clinical photographs to better illustrate the topics and concepts discussed in each chapter. Organization of chapters and content into four parts (General Classes and Properties of Dental Materials; Auxiliary Dental Materials; Direct Restorative Materials; and Indirect Restorative Materials) presents the material in a logical and effective way for better comprehension and readability. Balance between materials science and manipulation bridges the gap of knowledge between dentists and lab technicians. Major emphasis on biocompatibility serves as a useful guide for clinicians and educators on material safety. Distinguished contributor pool lends credibility and experience to each topic discussed. Critical thinking questions appearing in boxes throughout each chapter stimulate thinking and encourage classroom discussion of key concepts and principles. Key terms presented at the beginning of each chapter helps familiarize readers with key terms so you may better comprehend text material.
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    An exploration of the philosophical foundation of modern medicine which explains why such a medicine possesses the characteristics it does and where precisely its strengths as well as its weaknesses lie. Written in plain English, it should be accessible to anyone who is intellectually curious, lay-persons, and medical professionals alike. --From publisher description.
  • Philosophical practice 2002
  • Philosophy of medicine 2011
    This volume covers a wide range of conceptual, epistemological and methodological issues in the philosophy of science raised by reflection upon medical science and practice. Several chapters examine such general meta-scientific concepts as discovery, reduction, theories and models, causal inference and scientific realism as they apply to medicine or medical science in particular. Some discuss important concepts specific to medicine (diagnosis, health, disease, brain death). A topic such as evidence, for instance, is examined at a variety of levels, from social mechanisms for guiding evidence-based reasoning such as evidence-based medicine, consensus conferences, and clinical trials, to the more abstract analysis of experimentation, inference and uncertainty. Some chapters reflect on particular domains of medicine, including psychiatry, public health, and nursing. The contributions span a broad range of detailed cases from the science and practice of medicine, as well as a broad range of intellectual approaches, from conceptual analysis to detailed examinations of particular scientific papers or historical episodes. Chapters view philosophy of medicine from quite different angles Considers substantive cases from both medical science and practice Chapters from a distinguished array of contributors.
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    Examining stem cell biology from a philosophy of science perspective, this book clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. The first chapters discuss what stem cells are, how experiments identify them, and why these two issues cannot be completely separated. The basic concepts, methods and structure of the field are set out, as well as key limitations and challenges. The second part of the book shows how rigorous explanations emerge from stem cell experiments, and compares these to other kinds of scientific explanation. Model organisms, the role of genes, and the significance of collaboration are also discussed. The last part of the book considers relations to systems biology and clinical medicine, arguing that both the mathematical models of the former, and ethical principles of the latter, are necessary for stem cell biology to deliver on its promises.
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  • The management of venous pathology has been revolutionized by technological advancements. Venous disease is now managed with a wide variety of techniques that collectively allow physicians to diagnose and treat venous problems in ways that few surgeons would have anticipated even a decade ago. Techniques include laser ablation, radiofrequency ablation, chemical ablation (sclerotherapy), high ligation with or without stripping, ambulatory phlebectomy, powered phlebectomy, subfascial endoscopic perforator surgery, three-dimensional venography, and intravascular ultrasound. All of these topics are covered in this comprehensive, up-to-date textbook, which guides the practitioner through every aspect of care of the venous patient and includes essential background information on anatomy and pathophysiology. This book is exceptional in that it is based entirely on the curriculum designed for board certification by the American College of Phlebology (ACP). A further unique aspect of the text is the integration of ultrasound and various other imaging modalities, that play a fundamental role in diagnosis and management. The authors come from a wide range of specialties, mirroring the diversity of practitioners who care for patients with venous disease. The book will accordingly serve the needs of vascular and general surgeons, interventional radiologists, phlebologists, nurses, ultrasonographers, allied health professionals, and scientists, as well as American College of Phlebology fellowship candidates and those preparing for board examinations in vascular surgery.
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  • Osteo-renal cross-talk and phosphate metabolism by the FGF23-klotho system / Ohnishi, M., Razzaque, M.S. -- Extracellular phosphate as a signaling molecule / Michigami, T. -- Complex regulation and diverse functions of alpha-klotho / Maeda, R., Imura, A., Nabeshima, Y. -- Klotho and chronic kidney disease / Hu, M.C., Kuro-o, M., Moe, O.W. -- Nuclear receptor LXR : a new partner for sodium-dependent phosphate cotransporters / Caldas, Y., Giral, H., Sorribas, V., Levi, M. -- Phosphate toxicity and vascular mineralization / Razzaque, M.S. -- Vitamin D and type II sodium-dependent phosphate cotransporters / Kido, S., Kaneko, I., Tatsumi, S., Segawa, H., Miyamoto, K. -- Vitamin D in chronic kidney disease / Li, Y.C. -- Parathyroid function in chronic kidney disease : role of FGF23-klotho axis / Koizumi, M., Komaba, H., Fukagawa, M. -- FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6 / Uchihashi, K., Nakatani, T., Goetz, R., Mohammadi M., He, X., Razzaque, M.S. -- Can salivary phosphate levels be an early biomarker to monitor the evolvement of obesity? / Hartman, M.-L., Groppo, F., Ohnishi, M., Goodson, J.M., Hasturk, H., Tavares, M., Yaskell, T., Floros, C., Behbehani, K., Razzaque, M.S.
  • A high-resolution two dimensional gel- and pro-Q DPS-based proteomics workflow for phosphoprotein identification and quantitative profiling / Ganesh K. Agrawal and Jay J. Thelen -- Differential phosphoprotein labelling (DIPPL) using ³²P and ³³P / Aviva M. Tolkovsky and Andreas Wyttenbach -- Identification of oxidative stress-induced tyrosine phosphorylated proteins by immunoprecipitation and mass spectrometry / Ma Carmen Duran, Hong-Lin Chan, and John F. Timms -- Enrichment and characterization of phosphopeptides by immobilized metal affinity chromatography (IMAC) and mass spectrometry / Tine E. Thingholm and Ole N. Jensen -- The use of titanium dioxide micro-columns to selectively isolate phosphopeptides from proteolytic digests / Tine E. Thingholm and Martin R. Larsen -- Enrichment and separation of mono- and multiply phosphorylated peptides using sequential elution from IMAC prior to mass spectrometric analysis / Tine E. Thingholm , Ole N. Jensen, and Martin R. Larsen -- Use of stable isotope labeling by amino acids in cell culture (SILAC) for phophotyrosine protein identification and quantitation / Guoan Zhang and Thomas A. Neubert -- Hydrophilic interaction chromatography for fractionation and enrichment of the phosphoproteome / Dean E. McNulty and Roland S. Annan -- SILAC for global phosphoproteomic analysis / Genaro Pimienta, Raghothama Chaerkady, and Akhilesh Pandey -- Quantitative phospho-proteomics based on soluble nanopolymers / Anton Iliuk and W. Andy Tao -- Profiling the tyrosine phosphorylation state using SH2 domains / Kevin Dierck ... [et al.] -- An overview of the qualitative analysis of phosphoproteins by mass spectrometry / Philip R. Gafken -- The analysis of phosphoproteomes by selective labelling and advanced mass spectrometric techniques / Angela Amoresano ... [et al.] -- On-line liquid chromatography electron capture dissociation for the characterization of phosphorylation sites in proteins / Steve M.M. Sweet and Helen J. Cooper -- Quantification of protein phosphorylation by [mu]LC-ICP-MS / Ralf Krüger, Nico Zinn, and Wolf D. Lehmann -- Reverse-phase diagonal chromatography for phosphoproteome research / Kris Gevaert and Joël Vandekerckhove -- Chemical tagging strategies for mass spectrometry-based phospho-proteomics / Alexander Leitner and Wolfgang Lindner -- Antibody array platform to monitor protein tyrosine phosphorylation in mammalian cells / Alicia S. Chung and Y. Eugene Chin -- Protein tyrosine kinase characterization based on fully automated synthesis of (phospho)peptide arrays in microplates / W. Carl Saxinger -- Kinome profiling using peptide arrays in eukaryotic cells / Kaushal Parikh, Maikel P. Peppelenbosch, and Tita Ritsema -- ProMoST : a tool for calculating the pI and molecular mass of phosphorylated and modified proteins on two-dimensional gels / Brian D. Halligan -- Kinase-specific preiction of protein phosphorylation sites / Martin L. Miller and Nikolaj Blom -- Reconstructing regulatory kinase pathways from phosphopeptide data : a bioinformatics approach / Lawrence G. Puente, Robin E.C. Lee, and Lynn A. Megeney.
  • Purification of PDE6 isozymes from mammalian retina / Dana C. Pentia ... [et al.] -- Cyclic guanosine 5'-monophosphate binding to the regulatory GAF domains of photoreceptor phosphodiesterase / Rick H. Cote -- Renaturation of the catalytic domain of PDE4A expressed in escherichia coli as inclusion bodies / Wito Richter, Thomas Hermsdorf, and Dietrich Dettmer -- Determining the subunit structure of phosphodiesterases using gel filtration and sucrose density gradient centrifugation / Wito Richter -- Crystallization of cyclic nucleotide phosphodiesterases / Hengming Ke, Qing Huai, and Robert X. Xu -- Generation of PDE4 knockout mice by gene targeting / S.-L. Catherine Jin, Anne M. Latour, and Marco Conti -- Immunoprecipitating PDE2 phosphorylated and inactivated by an associated protein kinase / J. Kelley Bentley -- Investigation of extracellular signal-regulated kinase 2 mitogen-actived protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases / Elaine V. Hills, Miles D. Houslay, and George S. Baillie -- Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11 / James L. Weeks ... [et al.] -- Analysis of dimerization determinants of the PDE6 catalytic subunits / Khakim G. Muradov, Kimberley K. Boyd, and Nikolai O. Artemyev -- Interaction between catalytic and inhibitory subunits of PDE6 / Nikolai O. Artemyev -- Purification, reconstitution on lipid vesciles and assays of PDE6 and its activator G protein, transducin -- Theodore G. Wensel, Feng He, and Justine A. Malinski. Study of cyclic adenosine monophosphate microdomains in cells / Marco Mongillo ... [et al.] -- High-resolution measurements of cyclic adenosine monophosphate signals in 3D microdomains / Jeffrey W. Karpen and Thomas C. Rich -- Cygnets : in vivo characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP / Akira Honda ... [et al.] -- High-throughput screening of phosphodiesterase activity in living cells / Thomas C. Rich and Jeffrey W. Karpen -- Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts / Thèrése Keravis, Rima Thaseldar-Roumié, and Claire Lugnier -- Localization of the cyclic guanosine 3', 5'-monophosphate-hydrolysing phosphodiesterase type 9 in rat brain by nonradioactive in situ hybridization / Wilma C.G. Van Staveren and Marjanne Markerink-Van Ittersum -- Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells / Chen Yan -- Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B / Faiyaz Ahmad ... [et al.] -- Identification of promoter elements in the 5'-flanking region of the murine cyclic nucleotide phosphodiesterase 3B gene / Hanguan Liu ... [et al.] --
  • v. 2, 2011 Springer
    Vol. 1 / (ix, 306 p.) -- v. 2. / (x, 301 p.).
  • Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.
  • The Phosphatidylinositol 4-Kinases: Don't Call it a Comeback / Shane Minogue and Mark G. Waugh -- PIP Kinases from the Cell Membrane to the Nucleus / Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan and Richard Anderson -- The Phospholipase C Isozymes and Their Regulation / Aurelie Gresset, John Sondek and T. Kendall Harden -- Phosphoinositide 3-Kinases-A Historical Perspective / Alex Toker -- PI3Ks-Drug Targets in Inflammation and Cancer / Matthias Wymann -- Phosphoinositide 3-Kinases in Health and Disease / Alessandra Ghigo, Fulvio Morello, Alessia Perino and Emilio Hirsch -- Phosphoinositide Phosphatases: Just as Important as the Kinases / Jennifer M. Dyson, Clare G. Fedele, Elizabeth M. Davies, Jelena Becanovic and Christina A. Mitchell -- The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease / Nicholas R. Leslie, Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal and Clare G. Fedele, et al.
  • Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol.
  • Phospholipases
  • Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
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    v. 1. Metabolism.
  • O2-Sensitive Probes Based on Phosphorescent Metalloporphyrins / Ruslan I. Dmitriev and Dmitri B. Papkovsky -- O2 Analysis on a Fluorescence Spectrometer or Plate Reader / Alexander V. Zhdanov, James Hynes, Ruslan I. Dmitriev and Dmitri B. Papkovsky -- O2 Imaging in Biological Specimens / Andreas Fercher, Alexander V. Zhdanov and Dmitri B. Papkovsky.
  • This title in the PROCEDURES IN COSMETIC DERMATOLOGY SERIES presents up-to-the-minute, practical guidance on the hottest photodynamic therapy techniques shaping today's practice. Succinctly written and lavishly illustrated, it focuses on procedural how-to's and offer step-by-step advice on proper techniques, pitfalls, and tricks of the trade--so you can refine and hone your skills ... and expand your surgical repertoire. You'll find current, to-the-point guidance on the cosmetic use of PDT--edited by a pioneer in the field, Dr. Mitchel P. Goldman. Implement the newest procedures into your practice immediately and confidently--with the outstanding guidance you'll find in this volume of the PROCEDURES IN COSMETIC DERMATOLOGY SERIES. Get the best results when performing PDT for skin diseases, skin cancer and HPV, and skin rejuvenation, especially in aging and sun-damaged skin --all in one concise, accessible volume. Visualize techniques clearly with a wealth of color illustrations and photographs that depict cases as they appear in practice. Know the costs for each light source, and get recommendations from the experts on which light source is best for your practice. Ensure the safety of your clients with post-photodynamic therapy care information sheets for patients.
  • Part 1. Propagation of light -- ch. 1. Overview -- ch. 2. Review of optics -- ch. 3. Planar waveguides -- ch. 4. Cylindrical waveguides -- ch. 5. Losses in optical fibers -- ch. 6. Dispersion in optical fibers -- ch. 7. Fiber connections and diagnostics -- ch. 8. Photonic crystal optics -- ch. 9. Nonlinear optics -- Part 2. Generation and Detection of Light -- ch. 10. Review of semiconductor physics -- ch. 11. Light sources -- ch. 12. Light source to waveguide coupling efficiency -- ch. 13. Optical detectors -- ch. 14. Photodiode detectors -- Part 3. Laser light -- ch. 15. Lasers and coherent light -- ch. 16. Optical resonators -- ch. 17. Guassian beam optics -- ch. 18. Stimulated emission and optical gain -- ch. 19. Optical amplifiers -- ch. 20. Laser oscillation -- ch. 21. CW laser characteristics -- ch. 22. Pulsed lasers -- ch. 23. Survey of laser types -- Part 4. Light-based communications -- ch. 24. Optical communications -- Appendix A. Solid angle and the brightness theorem -- Appendix B. Fourier synthesis and the uncertainty relation.
  • Photoshop CS3 bible 2007
    ProQuest Safari
    2007 books24x7, SUNet ID login required.
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  • Ch. 1. Taxonomy of the genus Phyllanthus / Sheeja T. Tharakan -- ch. 2. Current pharmacopoeial status of Phyllanthus species : P. emblica, P. amarus, and P. fraternus / Raman Mohan Singh and Vivekanandan Kalaiselvan -- ch. 3. Cultivation, economics, and marketing of Phyllanthus species / B.R. Rajeswara Rao -- ch. 4. Phylogenetic analysis of Phyllanthus species / Srinivasu Tadikamalla -- ch. 5. Genetic resources of Phyllanthus in southern India : identification of geographic and genetic hot spots and its implication for conservation / G. Ravikanth [and others] -- ch. 6. Phytochemistry of the genus Phyllanthus / Lutfun Nahar, Satyajit D. Sarker, and Abbas Delazar -- ch. 7. Hyphenated techniques in the study of the genus Phyllanthus / Satyajit D. Sarker, Lutfun Nahar, and Abbas Delazar -- ch. 8. Anti-inflammatory activity of various species of Phyllanthus / K.B. Harikumar and Ramadasan Kuttan -- ch. 9. Hepatoprotective effects of plants in the family Phyllanthaceae / V.V. Asha -- ch. 10. Anticancer studies of Phyllanthus amarus / K.B. Harikumar and Ramadasan Kuttan -- ch. 11. Anticancer activity of Phyllanthus emblica / Jeena Joseph and Ramadasan Kuttan -- ch. 12. The In Vivo and In Vitro proapoptotic and antiangiogenic effects of Phyllanthus urinaria / Jong-Hwei S. Pang [and others] -- ch. 13. Phyllanthus and Hepatitis B, Hepatitis C, and HIV infections / S.P. Thyagarajan -- ch. 14. Antiviral activities of Phyllanthus orbicularis, an endemic Cuban species / Gloria del Barrio and Francisco Parra -- ch. 15. Diabetes and diabetic complications and Phyllanthus species / Geereddy Bhanuprakash Reddy and Palla Suryanarayana -- ch. 16. Chemoprotective, genotoxic, and antigenotoxic effects of Phyllanthus Sp / Rakesh K. Johri -- ch. 17. Antiaging effects of Phyllanthus species / Vasudevan Mani and Shanmugapriya Thulasimani -- ch. 18. Toxicity studies of Phyllanthus species / K.N.S. Sirajudeen -- ch. 19. Clinical trials involving Phyllanthus species / Mulyarjo Dirjomuljono and Raymond R. Tjandrawinata -- ch. 20. Immunomodulatory activity of Brahma Rasayana, an herbal preparation containing Phyllanthus emblica as the main ingredient / Praveen K. Vayalil, Ramadasan Kuttan, and Girija Kuttan -- ch. 21. Triphala : an Ayurvedic drug formulation / Sandhya T. Das and K.P. Mishra -- ch. 22. Kalpaamruthaa : a successful drug against various ailments / P. Sachdanandam and P. Shanthi.
  • Phylogenomics 2008
    Springer Protocols
    From gene-scale to genome-scale phylogenetics : the data flood in, but the challenges remain / Antonis Rokas and Stylianos Chatzimanolis -- Phylogenomic analysis of chromosome sorting and painting / Roscoe Stanyon and Gary Stone -- FISH for mapping single copy genes / Terje Raudsepp and Bhanu P. Chowdhary -- Construction of radiation hybrid panels / John E. Page and William J. Murphy -- Survey sequencing and radiation hybrid mapping to construct comparative maps / Christophe Hitte ... [et al.] -- Construction of high-resolution comparative maps in mammals using BAC-end sequences / Denis M. Larkin and Harris A. Lewin -- Amniote phylogenomics : testing evolutionary hypotheses with BAC library scanning and targeted clone analysis of large-scale sequences from reptiles / Andrew M. Shedlock, Daniel E. Janes, and Scott V. Edwards -- Comparative physical mapping : universal overgo hybridization probe design and BAC library hybridization / James W. Thomas -- Phylogenomic resources at the UCSC Genome Browser / Kate Rosenbloom ... [et al.] -- Computational tools for the analysis of rearrangements in mammalian genomes / Glenn Tesler and Guillaume Bourque -- Computational reconstruction of ancestral DNA sequences / Mathieu Blanchette ... [et al.] -- Sequencing and phylogenomic analysis of whole mitochondrial genomes of animals / Rafael Zardoya and Mónica Suárez -- Retroposons : genetic footrpints on the evolutionary paths of life / Hidenori Nishihara and Norihiro Okada -- LINE-1 elements : analysis by FISH and nucleotide sequences / Paul D. Waters ... [et al.] -- Identification of cryptic sex chromosomes and isolation of X- and Y-borne genes / Paul D. Waters ... [et al.]
  • Vascular Deficiency -- Disuse -- Infection -- Tumor -- Metabolic -- Neural -- Cold Injury (Frostbite) -- Heat Injury (Burns) -- Electric Injuries -- Compression -- Distraction -- Stress -- Irradiation -- Light Waves -- Sound Waves -- Shock Waves -- Atmospheric Pressure -- Oxygen -- Developmental -- Surgical -- Unknown.
  • This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors (e.g., medical, social cognitive, environmental) are discussed, and behavior change strategies for increasing physical activity in cancer survivors (e.g., counseling, print materials) are appraised. The final part of the book is devoted to further special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.
  • Promotes value of lifelong moderate exercise.
  • Ch. 1. History of physical activity contributions to public health / Amanda E. Paluch ... [et al.] -- Ch. 2. Physiological adaptations to moderate-intensity aerobic exercise / Arthur S. Leon and Scott Brown -- Ch. 3. The unique influence of sedentary behavior on health / Genevieve N. Healy -- Ch. 4. Physical activity in chronic disease prevention / Jared P. Reis and Bethany Barone Gibbs -- Ch. 5. Physical activity and injury prevention / Kenneth E. Powell -- Ch. 6. Physical activity in treatment of chronic conditions / J. Larry Durstine, Keith Burns, and Ryan Cheek -- Ch. 7. Physical activity in growth and development / Fátima Baptista and Kathleen F. Janz -- Ch. 8. Physical activity and healthy adulthood / Kelley K. Pettee Gabriel and Jennifer L. Gay -- Ch. 9. Physical activity and healthy aging / David M. Buchner -- Ch. 10. Physical activity and obesity / Catrine Tudor-Locke -- Ch. 11. Physical activity measurement / Stephen D. Herrmann -- Ch. 12. National guidelines for physical activity / Richard P. Troiano and David M. Buchner -- Ch. 13. Surveillance of physical activity / Janet E. Fulton and Susan A. Carlson -- Ch. 14. Physical activity promotion in underserved communities / Deborah Parra-Medina and Zenong Yin -- Ch. 15. Built environmental supports for walking / Paula Hooper ... [et al.] -- Ch. 16. Physical activity promotion in worksites / Joan Dorn and Cassandra Hoebbel -- Ch. 17. Promotion of physical activity in schools / Dianne Stanton Ward and Christopher Ford -- Ch. 18. Policy for physical activity promotion / Kelly R. Evenson and Semra A. Aytur
  • Epidemiology of overweight/obesity and cancer risk -- Epidemiology of physical activity and cancer risk -- Energetics and cancer: exploring a road less traveled -- Calorie restriction, exercise, and colon cancer prevention: a mechanistic perspective -- Mechanisms linking obesity to cancer risk -- Mechanisms underlying the effects of physical activity on cancer -- Physical activity, weight control, and cancer prognosis.
  • Preface -- Part I: Current Status of Physical Activity and Sedentary Behavior Research -- Physical Activity Levels and Physical Activity Recommendations in Japan -- Population Strategy for Physical Activity Promotion in the Community -- Promotion of Strength Training -- Does Newspaper Coverage Promote Cancer Prevention? -- Health Impact of Light -- Evaluation of Physical Activity and Sedentary Behavior -- Sedentary Behaviour -- Prevalence, Trends, and Correlates of Sedentary Behavior -- Part II: Effects of Physical Activity, Exercise, and Fitness on the Human Organism -- Responses of the Autonomic Nervous and Endocrine Systems to Exercise -- Exercise Modes and Vascular Functions -- Exercise, Appetite Control, and Body Weight Regulation -- Exercise and Food Intake -- Role of Physical Exercise on Postprandial Blood Glucose Responses to Low-Carbohydrate/High-Fat Diet Intake -- Posttranslational Modification of Proteins -- Relationship of Cardiorespiratory Fitness and Obesity Genes to Metabolic Syndrome in Adult Japanese Men -- Mechanisms Underlying the Suppression of Inflammatory Responses in Peritoneal Macrophages of Middle-aged Mice -- Effects of b2-Agonist Administration on Bacterial Phagocytosis by Splenic Macrophages in Mice -- Functional Roles of b2-Adrenergic Receptors in Skeletal Muscle Hypertrophy and Atrophy -- Part III: Physical Activity, Exercise, Nutrition, Aging, and Health -- The Role of Exercise and Nutrition in Lifestyle-related Disease -- Vasopressin V1a receptor gene and voluntary exercise in humans and mice -- The Role of Physical Activity in the Prevention of Atherosclerosis -- Association Between Exercise and Diet on Maintaining Bone Health in Postmenopausal Women and Female Athletes -- Pain Management Among Elderly People with Knee Pain -- Effective Exercise Programs Among Frail Elderly People -- Rowing -- Influence of Aging on Postural Control in Terms of Sensory Movements.
  • pt. 1. Principles of biophysical inquiry -- pt. 2. Foundations -- pt. 3. Building a model of biomolecular structure -- pt. 4. Function and action biological state space -- pt. 5. Methods for the measuring structure and function -- pt. 6. Physical constants.
  • Chapter 1. Heat, Work, and Energy (pages 1-21) -- Chapter 2. Entropy and Gibbs Energy (pages 23-42) -- Chapter 3. Applications of Thermodynamics to Biological Systems (pages 43-76) -- Chapter 4. Thermodynamics Revisited (pages 77-94) -- Chapter 5. Principles of Chemical Kinetics (pages 95-120) -- Chapter 6. Applications of Kinetics to Biological Systems (pages 121-152) -- Chapter 7. Fundamentals of Quantum Mechanics (pages 153-176) -- Chapter 8. Electronic Structure of Atoms and Molecules (pages 177-202) -- Chapter 9. X-ray Crystallography (pages 203-224) -- Chapter 10. Electronic Spectra (pages 225-252) -- Chapter 11. Circular Dichroism, Optical Rotary Dispersion, and Fluorescence Polarization (pages 253-276) -- Chapter 12. Vibrations in Macromolecules (pages 277-288) -- Chapter 13. Principles of Nuclear Magnetic Resonance and Electron Spin Resonance (pages 289-314) -- Chapter 14. Applications of Magnetic Resonance to Biology (pages 315-330) -- Chapter 15. Fundamentals of Statistical Mechanics (pages 331-356) -- Chapter 16. Molecular Simulations (pages 357-382) -- Chapter 17. Ligand Binding to Macromolecules (pages 383-414) -- Chapter 18. Hydrodynamics of Macromolecules (pages 415-440) -- Chapter 19. Mass Spectrometry (pages 441-456).
  • Print Material
    Approachable, yet thorough, this book presents physical chemistry in conceptual terms with a minimum of mathematics. Providing the basic knowledge and tools that every biologist should have to understand the quantitative interpretation of biological phenomena, it covers: Fundamentals of thermodynamics and chemical kinetics ; Fundamentals of spectroscopy and structure determination ; Ligand binding to macromolecules, hydrodynamics, and mass spectrometry. All techniques and concepts are clearly illustrated with relevant applications and examples from the biological sciences. Problems at the end of each chapter reinforce the principles.
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    General inspection and vital signs -- Dermatology-- Head, ears, eyes nose, and throat -- Pulmonary/critical care -- Cardiovascular System -- Gastrointestinal system -- Renal and genitourinary system -- Endocrinology -- Hematology and oncology -- Rheumatology -- Musculoskeletal system -- Neurology -- Geriatrics -- Infectious diseases -- Obstetrics and gynecology -- Pediatrics and neonatology -- Bonus chapter: The ten toughest physical diagnosis question ever written -- High yield facts.
  • Print Material
  • Chest inspection, palpation, and percussion / Salvatore Mangione -- Lung auscultation / Salvatore Mangione -- The abdomen / Salvatore Mangione -- Male genitalia, hernias, and rectal exam / Salvatore Mangione -- Pelvic examination / Salvatore Mangione -- Lymph nodes / Salvatore Mangione -- Neurologic examination / Enrica Arnaudo and Michael D. Kim -- Bedside diagnosis of coma / Salvatore Mangione -- The musculoskeletal system / Salvatore Mangione -- The extremities / Salvatore Mangione. Top 100 secrets -- General appearance, facies, and body habitus / Salvatore Mangione -- Vital signs / Salvatore Mangione -- The skin / Salvatore Mangione -- Eye examination / Salvatore Mangione -- The ear / Salvatore Mangione -- Nose and mouth / Salvatore Mangione -- Neck examination / Salvatore Mangione -- Thyroid gland / Salvatore Mangione -- Breast examination / Salvatore Mangione -- Cardiovascular physical exam / Salvatore Mangione -- Heart sounds and extra-sounds / Salvatore Mangione -- Cardiac auscultation murmurs / Salvatore Mangione --
  • Print Material
    Part I: An introduction to aging -- Part II: Physical changes in structure, capacity, and endurance -- Part III: Motor coordination, motor control, and skill -- Part IV: Physical-psychosocial relationships -- Part V: Physical performance and achievement.
  • About this Book -- Range of Motion -- Strenght Testing -- Strength Testing -- Rotator Cuff Disorders -- Disorders of the Long Head of the Biceps Tendon -- Glenohumeral Instability -- The Acromioclavicular Joint -- The Sternoclavicular Joint -- Scapular Dyskinesis -- Neurovascular Disorders.
  • Physical examination of the spine 2005
    Thieme eNeurosurgery
    The fundamentals -- Physical examination of the cervical spine -- Physical examination of the thoracic spine -- Physical examination of the lumbosacral spine.
  • "This completely updated top-seller in physical medicine and rehabilitation continues the tradition of the highly popular Secrets Series. From anatomy and physiology of the nervous and musculoskeletal system to medical complications in rehabilitation to work and rehabilitationthis book presents all the key elements you need for clinical use, rounds, and board preparation."--Publisher's website.
  • Print Material
    The physiatric history and physical examination -- Examination of the pediatric patient -- Adult neurogenic communication disorders -- Psychological assessment and intervention in rehabilitation -- Gait analysis: technology and clinical applications -- Impairment rating and disability determination -- Neurologic and musculoskeletal imaging studies -- Quality and outcome measures for medical rehabilitation -- Electrodiagnostic medicine I: fundamental principles -- Electrodiagnostic medicine II: clinical evaluation and findings -- Electrodiagnostic medicine III: case studies -- Rehabilitation and prosthetic restoration in upper limb amputation -- Rehabilitation and prosthetic restoration in lower limb amputation -- Upper limb orthotic devices -- Lower limb orthotic devices -- Spinal orthoses -- Wheelchairs and seating systems -- Therapeutic exercise -- Manipulation, traction, and massage -- Physical agent modalities -- Electrical stimulation -- Integrative medicine in rehabilitation -- Computer assistive devices and environmental controls -- Peripheral joint and soft tissue injection techniques -- Spinal injection techniques -- Achieving functional independence -- Rehabilitation of patients with swallowing disorders -- Management of bladder dysfunction -- Neurogenic bowel: dysfunction and rehabilitation -- Spasticity management -- Sexuality dysfunction and disability -- Prevention and management of chronic wounds -- Cardiac rehabilitation -- Pulmonary rehabilitation -- Employment of persons with disabilities -- Rheumatic diseases -- Common neck problems -- Musculoskeletal disorders of the upper limb -- Musculoskeletal disorders of the lower limb -- Low back pain -- Osteoporosis -- Chronic pain -- Muscle pain syndromes -- Sports medicine -- Occupational rehabilitation -- Motor neuron diseases -- Rehabilitation of patients with neuropathies -- Myopathic disorders -- Traumatic brain injury -- Stroke syndromes -- Degenerative movement disorders of the central nervous system -- Multiple sclerosis -- Cerebral palsy -- Myelominingocele and other spinal dysraphisms -- Spinal cord injury -- Lower limb peripheral vascular disease -- Cancer rehabilitation -- Burn rehabilitation -- Geriatric rehabilitation -- Transplantation of organs: rehabilitation to maximize outcomes -- International physical medicine and rehabilitation.
  • 2012 ClinicalKey
    Section 1. Foundational concepts in rehabilitation -- section 2. Upper extremity -- section 3. Spine -- section 4. Lower extremity -- section 5. Restoration of athletic performance.
  • "Clinical evidence clearly demonstrates that physical therapeutic measures begun as soon as possible after a stroke, often within 24 to 48 hours, greatly increase everyday competence and quality of life. Physical Therapy for the Stroke Patient: Early Stage Rehabilitation covers all the issues that physical therapists must deal with in this critical period: assessment of patients' abilities; care during the acute phase; early mobilization; effects of medication; risk factors; ethical questions; and much more. It provides complete guidelines on how to examine and treat the patient, the dosage" of physical therapy required, and the key differences between early and late stage rehabilitation after stroke. Special Features Information-packed chapter on Optimizing Functional Motor Recovery after Stroke," written by J. Carr and R. Shepherd, pioneers in the field and the first to correlate motor learning and stroke recovery Case studies throughout the book offering direct, hands-on examples of evaluation and treatment methods Nearly 150 color photographs demonstrating step-by-step physical therapy techniques used in actual practice Hundreds of references to the literature that support the evidence-based approach presented in the book For all physical and occupational therapists who must answer the question, How much therapy will help my patient?", this book provides clear, well-informed answers. Not only will it increase your therapeutic skills and confidence, but it will also expand your knowledge of the medical issues and long-term outcomes for the post-stroke patients in your care"--Provided by publisher.
  • Guide to practice -- Mechanics of movement and evaluation -- Functional anatomy and mechanics -- Throwing injuries -- Examinations and evaluation of the shoulder -- Neurologic considerations -- Interrelationship of the spine, rib cage, and shoulder -- Neural tissue evaluation and treatment -- Sensory integration and neuromuscular control of the shoulder -- Evaluation and treatment of brachial plexus lesions -- Special considerations -- Impingement syndrome and impingement-related instability -- Shoulder instability -- Frozen shoulder -- Etiology and evaluation of rotator cuff pathologic conditions and rehabilitation -- Visceral referred pain to the shoulder -- Treatment approaches -- Manual therapy techniques -- Muscle length testing and electromyographic evidence for manual strength testing and exercises for the shoulder -- Myofascial trigger points of the shoulder -- Strength training concepts -- Surgical considerations -- Rotator cuff repairs -- Surgical approach to shoulder instabilities -- Total shoulder replacements.
  • pt. 1. Getting started as physician-scientist. -- Beginnings -- Is a physician-scientist career right for you? -- Training as a physician-scientist -- pt. 2. Launching your career as a physician-scientist. -- Getting a job -- Appointments, tenure, promotions, and sabbaticals -- Teaching -- Administration -- Research -- pt. 3. Building your career as a physician-scientist. -- Writing -- Publishing -- Grants -- Grantsmanship -- Peer review of grant applications -- Managing your team, time, and money -- Mentorship -- Lectures and presentations -- Relations with industry -- pt. 4. Parting words of advice : putting it all together. -- Balancing research, clinical activities, and family life -- Improving the physician-scientist pathway -- Concluding remarks.
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  • Goals for your investment returns -- The magnificence of compound interest -- Arrogance, ego, and greed -- The mark -- It's not much, I can afford to lose it -- Define specific goals -- Thrift -- Invest in what you know -- Make your own investment decisions -- Documents required for financial security -- The importance of relationships -- Paying daily bills -- Your home -- Funding your children's education -- Insurance -- Funding retirement -- Who can you trust -- The malevolence of debt -- The perniciousness of fees -- Tips : real opportunities or useless information -- Areas where caution is essential or that should be completely avoided -- Yes or no -- Dealing with bankers -- Asset allocation and diversification -- How to identify real investment opportunities -- When to buy -- When to sell -- Stocks, bonds, and mutual funds -- Real estate other than your home -- Other types of investments -- Obtaining investment information -- Investment strategies of the pros -- Some miscellaneous tidbits of advice.
  • Introductory Chapters -- Amino acids -- Organic acids -- Vitamins and neurotransmitter -- Energy metabolism -- Organelles -- Selected disorder -- Biochemical phenotypes of questionable clinical significance -- Profiles.
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    " ... explains and describes the applications of philosophy, logic and critical thinking in particular, in medicine."--Back cover.
  • Physicians at war: the dual-loyalties challenge / Fritz Allhoff -- Dual-loyalty and human rights in health professional practice: proposed guidelines and institutional mechanisms / International Dual-Loyalty Working Group -- Guidelines to prevent the malevolent use of physicians in war / Michael E. Frisina -- Dual disloyalties: law and medical ethics at Guantanamo Bay / Jonathan H. Marks -- Toward a framework for military health ethics / Gervase Pearce, Peter Saul -- Physician involvement in hostile interrogations / Fritz Allhoff -- Indecent medicine revisited: considering physician involvement in torture / Richard Matthews -- Torture and the regulation of the health care professions / John Lunstroth -- Is medicine a pacifist vocation or should doctors help build bombs? / Michael L. Gross -- The case against doctor involvement in weapons design and development / Vivienne Nathanson -- Armed conflict and value conflict: case studies in biological weapons / Michael J. Selgelid -- Ethics and the dual-use dilemma in the life sciences / Seumas Miller, Michael J. Selgelid -- Triage priorities and military physicians / Marcus P. Adams -- Medical neutrality and political activism: physicians' roles in conflict situations / Justin M. List.
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    Principles of cancer chemotherapy -- Chemotherapeutic and biologic drugs -- Guidelines for chemotherapy and dosing modifications -- Common chemotherapy regimens in clinical practice -- Antiemetic agents for the treatment of chemotherapy-induced nausea and vomiting.
  • Increasingly, physicians are leveraging their medical training and expertise to pursue careers in non-traditional arenas. Their goals are diverse: · Explore consulting as a way to improve patient care· Lay the foundation for a career in academic medicine· Provide leadership in healthcare · Strengthen ties between a clinic and the community· Broaden ones experience as a medical student · As a journalist or writer, open a window onto medicine for non-experts Some physicians will pursue another degree, while others may not, in anticipation of moving into public service, business, education, law, or organized medicine. Their common ground is the desire to enhance their professional fulfillment.Drs. Urman and Ehrenfelds book features individual chapters on the wide array of non-traditional careers for physicians, each one written by an outstanding leader in medicine who him- or herself has successfully forged a unique career path. A final chapter brings together fascinating brief profiles case studies of physicians who have distinguished themselves professionally outside of traditional settings. Suitable for readers at any point in their medical career practitioners, fellows, residents, and medical students who want to explore possibilities beyond traditional medical practice, the book also sets out common-sense advice on topics such as work-life balance, mentorship, and the relationship between personality and job satisfaction.
  • Structure of Matter -- Radioactive Decay -- Kinetics of Radioactive Decay -- Statistics of Radiation Counting -- Production of Radionuclides -- Interaction of Radiation with Matter -- Gas-Filled Detectors -- Scintillation and Semiconductor Detectors -- Gamma Cameras -- Performance Parameters of Gamma Cameras -- Digital Computers in Nuclear Medicine -- Single Photon Emission Computed Tomography -- Positron Emission Tomography -- Internal Radiation Dosimetry -- Radiation Biology -- Radiation Regulations and Protection.
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    "In Physics in Mind, eminent biophysicist Werner R. Loewenstein seeks answers to these perplexing questions in the mechanisms of physics. Bringing information theory--the idea that all information can be quantified and encoded in bits--to bear on recent advances in the neurosciences, Loewenstein reveals inside the brain a web of immense computational power capable of rendering a coherent representation of the world outside. He guides us on an exhilarating journey along the sensory data stream of the brain--the stream that nurses our cognitions--and we see how the vast amounts of information coming in from the world outside get processed by the web, how its neurons gradually extract meaning from this hodgepodge, and how they arrive at a coherent picture of the world." -- [Publisher-supplied data]
  • 2012 ClinicalKey
    What is nuclear medicine? -- Basic atomic and nuclear physics -- Modes of radioactive decay -- Decay of radioactivity -- Radionuclide and radiopharmaceutical production -- Interaction of radiation with matter -- Radiation detectors -- Electronic instrumentation for radiation detection systems -- Nuclear counting statistics -- Pulse-height spectrometry -- Problems in radiation detection and measurement -- Counting systems -- The gamma camera : basic principles -- The gamma camera : performance characteristics -- Image quality in nuclear medicine -- Tomographic reconstruction in nuclear medicine -- Single photon emission computed tomography -- Positron emission tomography -- Hybrid imaging : SPECT/CT and PET/CT -- Digital image processing in nuclear medicine -- Tracer kinetic modeling -- Internal radiation dosimetry -- Radiation safety and health physics.
  • "The text is organized into concise chapters, each discussing an important point relevant to clinical MR and illustrated with images from routine patient exams. The topics covered encompass the breadth of the field, from imaging basics and pulse sequences to advanced topics including contrast-enhanced MR angiography, spectroscopy, perfusion, and advanced parallel imaging techniques. Discussion of the latest hardware and software innovations--for example, MR-PET, interventional MR, compressed sensing, and multishot EPI--is included because these topics are critical to current and future advances. Included in the third edition are a large number of new topics, keeping the text up-to-date in this increasingly complex field. The text has also been revised to include additional relevant clinical images, to improve the clarity of descriptions, and to increase the depth of content"--Provided by publisher.
  • Terminology, the standard human, and scaling -- Statics of the body -- Motion -- Mechanical properties of the body -- Muscles -- Metabolism: energy, heat, work, and power -- Fluid pressure, fluid flow in the body, and motion in fluids -- Cardiovascular system -- Lungs and breathing -- Sound, speech, and hearing -- Light, eyes, and vision -- Electrical and magnetic properties -- Feedback and control -- Appendix A. Symbols and units -- Appendix B. Locator of major anatomical and anthropometric information -- Appendix C. Differential equations -- Appendix D. Similar model systems -- Appendix E. Biophysics of the human body.
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    Bd. 1. Die Behandlung innerer Krankheiten durch Klima, spectrale Strahlung und Freiluft, Meteorotherapie.
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    Pt 1 Efficiency of young men under temperate conditions -- Pt. II, v. 1. Efficiency of young men under conditions of moderate cold -- Pt. III. Efficiency of young men under conditions of moist heat -- Pt. III, v.2. Efficiency of young men under conditions of moist heat appendices of methods and original data -- Pt. IV. Integrative study of the all-purpose survival ration for temperate, cold and hot weather.
  • "Physiology and medicine are interrelated disciplines, and this is perhaps nowhere more apparent than in the field of mineral metabolism. This book presents information on the physiological principles regulating the response of mineral homeostasis on genetic, molecular, environmental, and nutritional factors. Chapters cover calcium and vitamin D nutrition, intestinal calcium absorption, plasma calcium homeostasis, renal handling of calcium, calcium sensing receptors, plasma phosphate homeostasis, endocrine actions of vitamin D, parathyroid hormone, calcitonin, and the calcification process"-- Provided by publisher.
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    v. 1. Mammalian populations, by J. B. Calhoun, J. J. Christian.--v. 2. Mammalian reactions to stressful environments.
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    1. Bd. Die Stoffe -- 2. Bd. Der Stoffwechsel.
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  • Recent Developments in the Molecular Taxonomy of Fungi / Roland W.S. Weber -- Sordaria macrospora, a Model System for Fungal Development / Ulrich Kück, Stefanie Pöggeler, Minou Nowrousian, Nicole Nolting and Ines Engh -- Inteins - Selfish Elements in Fungal Genomes / Skander Elleuche and Stefanie Pöggeler -- Apoptosis in Fungal Development and Ageing / Diana Brust, Andrea Hamann and Heinz D. Osiewacz -- Communication of Fungi on Individual, Species, Kingdom, and Above Kingdom Levels / Ursula Kües and Mónica Navarro-González -- Yeast Killer Toxins: Fundamentals and Applications / Friedhelm Meinhardt and Roland Klassen -- Evolutionary and Ecological Interactions of Mould and Insects / Marko Rohlfs, Monika Trienens, Ulrike Fohgrub and Frank Kempken -- Endophytic Fungi, Occurrence and Metabolites / Daniela Weber -- Fungal Origin of Ergoline Alkaloids Present in Dicotyledonous Plants (Convolvulaceae) / Eckhard Leistner and Ulrike Steiner -- Secondary Metabolites of Basidiomycetes / Anja Schüffler and Timm Anke -- Identification of Fungicide Targets in Pathogenic Fungi / Andrew J. Foster and Eckhard Thines -- Helminth Electron Transport Inhibitors Produced by Fungi / Rokuro Masuma, Kazuro Shiomi and Satoshi Ōmura -- Cyclic Peptides and Depsipeptides from Fungi / Heidrun Anke and Luis Antelo -- Fungal Genome Mining and Activation of Silent Gene Clusters / Axel A. Brakhage, Sebastian Bergmann, Julia Schuemann, Kirstin Scherlach and Volker Schroeckh, et al. -- Non-Ribosomal Peptide Synthetases of Fungi / Katrin Eisfeld -- Biosynthesis of Fungal Polyketides / Julia Schuemann and Christian Hertweck -- Physiological and Molecular Aspects of Ochratoxin A Biosynthesis / Rolf Geisen and Markus Schmidt-Heydt -- Genetic and Metabolic Engineering in Filamentous Fungi / Jochen Schmid, Ulf Stahl and Vera Meyer.
  • Written by internationally recognized leaders in hyperbaric oxygen therapy (HBOT) research and practice, this exciting new book provides evidence-based, practical, useful information for anyone involved in HBOT. It outlines the physiologic principles that constitute the basis for understanding the clinical implications for treatment and describes recent advances and current research, along with new approaches to therapy. This book is an essential tool for anyone who cares for patients with difficult-to-heal wounds, wounds from radiation therapy, carbon monoxide poisoning, and more. Provides comprehensive coverage of pathophysiology and clinically relevant information so you can master the specialty. Covers the relevance of HBOT in caring for diverse populations including critical care patients, infants and pediatric patients, and divers. Features a section on the technical aspects of HBOT to provide insight into the technology and physics regarding HBO chambers. Presents evidence to support the effectiveness of HBOT as well as the possible side effects. Describes situations where HBOT would be effective through indication-specific chapters on chronic wounds, radiation and crush injuries, decompression sickness, and more.
  • Part I. Overview of Chloride Transporters and Channels -- Part II. Current Methods for Studying Chloride Regulation -- Part III. From Cloning to Structure, Function and Regulation of Chloride Transporters and Channels -- Part IV. Cation-Chloride Cotransporters in Neural Function and Dysfunction -- Part V. Cation-Chloride Cotransport in Choroid Plexus and Blood-Brain Barrier.
  • The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
  • Measuring endogenous electric fields / Richard Nuccitelli -- Investigation systems to study the biological effects of weak physiological electric fields / Francis X. Hart -- Endogenous bioelectric signals as morphogenetic controls of development, regeneration, and neoplasm / Michael Levin -- Stem cell physiological responses to noninvasive electrical stimulation / Igor Titushkin ... [et al.] -- Electrical signals control corneal epithelial cell physiology and wound repair / Colin D. McCaig -- Physiological electric fields can direct keratinocyte migration and promote healing in chronic wounds / Christine E. Pullar -- Electrical control of angiogenesis / Entong Wang ... [et al.] -- Inflammatory cell electrotaxis / Francis Lin and Christine E. Pullar -- Effects of DC electric fields on migration of cells of the musculoskeletal system / Najmuddin J. Gunja, Clark T. Hung, and J. Chlöe Bulinski -- Neuronal growth cone guidance by physiological DC electric fields / Ann M. Rajnicek -- Can applied voltages be used to produce spinal cord regeneration and recovery in humans? / Richard Ben Borgens -- Bioelectricty of cancer : voltage-gated ion channels and direct-current electric fields / Mustafa B. A. Djamgoz.
  • Maternal Exercise Throughout Gestation and Fetal Development -- Effects of Maternal Exercise on Labor and Delivery -- Fetal and Postnatal Growth and Development -- Effect on Postnatal Health and Beyond -- What are the Barriers to and What is OK for an Exercise Study -- Conclusions.
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    v. 1. Optics -- v. 2. Vision.
  • 2012 ClinicalKey
    The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. Physiology of the Gastrointestinal Tract, 5/e covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal functionEach section edited by preeminent scientist in the fieldUpdated, four-color illustrations.
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    High-Yield Facts -- General Principles: Cellular Physiology -- General Principles: Multisystem Processes -- Physiology of the Hematopoietic and Lymphoreticular Systems -- Neurophysiology -- Musculoskeletal Physiology -- Respiratory Physiology -- Cardiovascular Physiology -- Gastrointestinal Physiology -- Renal and Urinary Physiology -- Reproductive Physiology -- Endocrine Physiology.
  • Clear, consistent, and user-friendly, the updated edition of Physiology, by renowned physiology instructor Dr. Linda Costanzo, offers a comprehensive overview of core physiologic concepts at the organ system and cellular levels. It presents information in a short, simple, and focused manner, making it an ideal combination textbook and review guide for the USMLE Step 1. You'll grasp all the essential and relevant physiology knowledge you need for absolute success in school and on your exams! Build a strong understanding of the underlying principles of cellular physiology, the autonomic nervous system, and neurophysiology, as well as the cardiovascular, respiratory, renal, acid-base, gastrointestinal, endocrine, and reproductive organ systems.\Grasp physiology principles with absolute clarity through step-by-step explanations, easy-to-follow diagrams, and a full-color design, in addition to physiology equations and sample problems integrated throughout the text. Effortlessly study important points and reinforce your understanding of physiology with the help of chapter summaries and review questions. Access the entire contents online at Student Consult, including an image bank, 8 animations, "Ask the Author" section, and FAQs.
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    "Preface The aim of this book is to show that many aspects of human physiology lend themselves to numerical analysis. Many ways of monitoring physiological function also rely on an understanding of physics and engineering to appreciate fully how they operate. The book arises out of an undergraduate course in medical biophysics and a postgraduate course in biomedical instrumentation the authors were involved in for many years. Although the emphasis is on numerical analysis only, a basic knowledge of mathematics is assumed and every effort is made to supplement mathematical formulae with qualitative explanations and illustrations to encourage an intuitive grasp on the processes involved. Most of the chapters have a range of numerical tutorial problems with, in most cases, worked solutions. These are based on examination questions at the middle and senior undergraduate level. For some of the material, the computational package MATLABʼ offers a convenient way to gain insight into some of the more advanced mathematical analysis of physiological or of clinical monitoring systems. Suitable MATLAB code is provided where this might aid understanding. I acknowledge the help of colleagues in the preparation of this book. Particular chapters have been authored as follows: Anthony Bartel, Per Line, Peter Cadusch, Joseph Ciorciari, David and Sheila Crewther, John Patterson , Mark Schier, Bruce Thompson. In addition, others have been associated with teaching the course over many years. These include: Peter Alabaster, David Liley, Ric Roberts and David Simpson"--Provided by publisher.
  • "Physiology--An Illustrated Review helps you master important physiologic facts and concepts and teaches you how to apply that knowledge successfully on course exams and in daily practice. This indispensable review book includes 200 spectacular, full-color illustrations depicting cardiologic, cellular, and renal function. It also includes all the regular series features, including 400 print and online review questions and explanatory answers"--Provided by publisher.
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    Cell physiology -- Neurophysiology -- Cardiovascular physiology -- Respiratory physiology -- Renal and acid-base physiology -- Gastrointestinal physiology -- Endocrine physiology.
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  • Technophysiology, evolution, and aging : towards a new image of aging / Paola S. Timiras -- Are there age-related changes in flavonoid bioavailability? / C-Y. Oliver Chen and Jeffrey B. Blumberg -- Trends in the analysis of phytochemicals : flavonoids and carotenoids / Eunmi Koh and Alyson E. Mitchell -- Anti-inflammatory botanicals : a case study of genetic screens as part of a pharmacogenomic approach / Moul Dey ... [et al.] -- Characteristics and functions of lutein and zeaxanthin within the human retina / Billy R. Hammond, Jr. and Lisa M. Renzi -- Phytochemicals and the aging brain / Stephane Bastianetto and Remi Quirion -- Green tea : skin care and skin diseases / Stephen D. Hsu -- Pomegranate phenolics antioxidant activities protect against cardiovascular diseases / Michael Aviram, Mira Rosenblat, and Bianca Fuhrman -- Customizing dietary recommendations by genotype in the era of genomics / Sina Vakili, Grace Jooyoung Shin, and Marie A. Caudill -- Development of a botanical combination product for allergy symptoms / Marc Lemay ... [et al.] -- Genotype-selective inhibition of IL-1 by botanicals : a nutrigenetics proof of principle / R. Keith Randolph.
  • "An examination of foods, botanicals, and phytochemicals as they relate to the prevention of age-related chronic diseases, this book discusses herbs and spices in cancer prevention; wine, phenolics, and cancer; anthocyanins in cardiovascular health; anti-inflammatories; skin photoprotection; beny phytochemicals; green tea catechins; and cognitive function in the elderly. The book begins with an overview of phytonutrients in human health and disease, and covers chronic disease prevention, bone and joint health, skin health, obesity and metabolism, and brain health. The final chapter describes an analytical technique 'proving very powerful in phytonutrient research in humans"--Provided by publisher.
  • Effect of Lifestyle, Aging, and Phytochemicals on the Onset of Neurological Disorders -- Beneficial Effects of Extra Virgin Olive Oil (n-9 Fatty Acids) on Neurological Disorders -- Beneficial Effects of Flaxseed Oil (n-3 Fatty Acids) on Neurological Disorders -- Beneficial Effects of Flavonoids on Neurological Disorders -- Beneficial Effects of Green Tea Catechins on Neurological Disorders -- Beneficial Effects of Curcumin on Neurological Disorders -- Beneficial Effects of Resveratrol on Neurological Disorders -- Beneficial Effects of Ginkgo biloba in Neurological Disorders -- Beneficial Effects of Garlic Components on Neurological Disorders -- Beneficial Effects of Propolis on Neurological Disorders -- Perspective and Direction for Future Research on Phytochemicals in Neurological Disorders.
  • Generic Comments on Isoflavones and Other Phytoestrogens -- Chapter 1. Brief Historical Overview of Isoflavone Research / Mark Messina -- Chapter 2. Soy Isoflavones as Functional Ingredients in Women's Health / Clare M. Hasler and Susan Kundrat -- Chapter 3. Isoflavone Supplements: Arguments For and Against Their Use / Mark Messina -- Chapter 4. Industrial Processing and Preparation of Isoflavones / Eric T Gugger -- Food Sources and Composition of Phytoestrogens -- Chapter 5. Human Dietary Sources of Phytoestrogens and Methods of Determination / Chung-Ja C. Jackson and H.P. Vasantha Rupasinghe -- Chapter 6. Tables of Isoflavone, Coumestan, and Lignan Data / Chung-Ja C. Jackson and G. Sarwar Gilani -- Measurement Methodology of Phytoestrogens in Blood and Tissues -- Chapter 7. Analysis of Phytoestrogens in Biological Samples by Mass Spectrometry / Jeevan K. Prasain, Chao-Cheng Wang, and Stephen Barnes -- Chapter 8. Measurement Methodology for Phytoestrogens in Blood and Urine / Mariko Uehara -- Chapter 9. Metabolism and Disposition of Genistein, the Principal Soy Isoflavone / Daniel R. Doerge, Richard H. Luecke, and John F Young -- Digestion, Absorption and Metabolism of Isoflavones -- Chapter 10. Digestion, Absorption and Metabolism of Isoflavones / Roger A. King -- Cellular Mechanism of Action, Including Estrogen Receptors -- Chapter 11. Cellular Mechanisms of Action Including Estrogen Receptors: ER[alpha] and [beta] / Sari Mäkelä and Jan-Åke Gustafsson -- Chapter 12. Effects of Phytoestrogens on Bone Cells: Genomic and Nongenomic Mechanisms / Xiaowei Chen and John J.B. Anderson -- Cardiovascular Effects -- Chapter 13. Epidemiology of Soy Isoflavones and Cardiovascular Disease / M.Z. Vitolins, M.S. Anthony, and G.L. Burke -- Chapter 14. Soy/Isoflavones and Risk Factors for Cardiovascular Disease / Mary S. Anthony -- Chapter 15. Soy Proteins, Isoflavones, Cardiovascular Risk Factors, and Chronic Disease / David J.A. Jenkins, Cyril WC. Kendall, and Augustine Marchie -- Chapter 16. Lipoprotein Effects of Soybean Phytoestrogens / Sandra R. Teixeira and John W Erdman, Jr. -- Chapter 17. Effects of Free (Aglycone) Phytoestrogens and Metabolites on Cardiovascular Functions and Cancer / Paul Nestel and Alan Husband -- Skeletal Effects -- Chapter 18. Association Between Soy and/or Isoflavones and Bone: Evidence from Epidemiologic Studies / Mary S. Anthony, John J.B. Anderson, and D. Lee Alekel -- Chapter 19. Skeletal Effects of Phytoestrogens in Humans: Bone Mineral Density and Bone Markers / John J.B. Anderson and D. Lee Alekel -- Chapter 20. Skeletal Effects of Phytoestrogens: Rodent Models: Diet / Bahram H. Arjmandi and Brenda J. Smith -- Cancer -- Chapter 21. Phytoestrogens and Cancer: Epidemiologic Evidence / Anna H. Wu -- Chapter 22. Flaxseed Lignans: Health Benefits, Bioavailability, and Safety / Lilian U. Thompson and Wendy E. Ward -- Chapter 23. Phytoestrogens, Estrogens and Risk of Colon Cancer / Maurice R. Bennink and Elizabeth A. Rondini -- Chapter 24. Phytoestrogen Actions in the Breast and Uterus / Charles E. Wood, Stephen Barnes, and J. Mark Cline -- Chapter 25. Induction of Apoptosis by Genistein: Potential Applications in Cancer Prevention and Treatment / Andreas I. Constantinou -- Renal Effects -- Chapter 26. Phytoestrogens: Diabetic Nephropathy / Tammy J. Stephenson and James W Anderson -- Premenopausal Hormone Effects -- Chapter 27. Hormonal Effects of Phytoestrogens in Premenopausal Women / Alison M. Duncan, William R. Phipps, and Mindy S. Kurzer -- Postmenopausal, Potential Alternative to Traditional HRT -- Chapter 28. Phytoestrogens: Effects on Menopausal Symptoms / Fabien S. Dalais -- Chapter 29. Use of Soy Isoflavones as an Alternative to Traditional Hormone Replacement Therapy / Mara Z. Vitolins, Mary S. Anthony, and Gregory L. Burke -- Safety and Potential Toxicity -- Chapter 30. Deleterious Effects of Genistein Follow Exposure During Critical Stages of Development / Retha R. Newbold, Wendy Jefferson, Elizabeth Padilla-Banks, and Bill Bullock -- Chapter 31. Evaluation of Phytoestrogen Safety and Toxicity in Rodent Models That Include Developmental Exposure / Barry Delclos -- Chapter 32. The Health Consequences of Soy Infant Formula, Soy Protein Isolate, and Isoflavones / Thomas M. Badger, Martin J.J. Ronis, Reza Hakkak, and Sohelia Korourian -- Chapter 33. Public Health Implications of Dietary Phytoestrogens / Joel Rotstein, and G. Sarwar Gilani.
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  • Pichia protocols. 2nd ed. 2007
    Springer Protocols
    Introduction : distinction between Pichia pastoris and other expression systems / James M. Cregg -- Vectors and strains for expression / Joan Lin-Cereghino and Geoff P. Lin-Cereghino -- DNA-mediated transformation / James M. Cregg -- Rational design and optimization of fed-batch and continuous fermentation / Wenhui Zhag, Mehmet Inan, and Michael M. Meagher -- Saturation of the secretory pathway by overexpression of a hookworm (Necator americanus) protein (Na-ASP1) / Mehmet Inan ... [et al.] -- Purification of the N- and C-terminal subdomains of recombinant heavy chain fragment C of botulinum neurotoxin serotype C / Jicai Huang ... [et al.] -- Rapid screening of chromatography resins for the purification of proteins / Sandra E. Ríos, Erin M. Giaccone, and Tillman U. Gerngross -- Characterization of O-linked saccharides on glycoproteins / Roger K. Bretthauer -- Modification of the N-glycosylation pathway to produce homogeneous human-like glycans using glycoswitch plasmids / Wouter Vervecken ... [et al.] -- N-linked glycan characterization of heterologous proteins / Huijan Li ... [et al.] -- Heavy labeling of recombinant proteins / Eric Rodriguez -- Selenomethionine labeling of recombinant proteins / Anna M. Larsson and T. Alwyn Jones -- Selective isotopic labeling of recombinant proteins using amino acid auxotroph strains / James W. Whittaker -- Classical genetics / Ilya Tolstorukov and James M. Cregg -- Identification of pexophagy genes by restriction enzyme-mediated integration / Laura A. Schroder, Benjamin S. Glick, and William A. Dunn, Jr. -- Characterization of protein-protein interactions : application to the understanding of peroxisome biogenesis / Sebastien Leon ... [et al.] -- Localization of proteins and organelles using fluorescence microscopy / Jean-Claude Farre ... [et al.] -- Fluorescence microscopy and thin-section electron microscopy / Benjamin S. Glick.
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    A history of the science of pigmentation / Sidney N. Klaus -- Comparative anatomy and physiology of pigment cells in nonmammalian tissues / Joseph T. Bagnara & Jiro Matsumoto -- General biology of mammalian pigmentation / Walter C. Quevedo Jr. & Thomas J. Holstein -- Extracutaneous melanocytes / Raymond E. Boissy & Thomas J. Hornyak -- Regulation of melanoblast migration and differentiation / David M. Parichy, Mark V. Reedy, & Carol A. Erickson -- Melanoblast development and associated disorders / Richard A. Spritz -- Biogenesis of melanosomes / Raymond E. Boissy, Marjan Huizing, & William A. Gahl -- Melanosome trafficking and transfer / Glynis A. Scott -- Melanosome processing in keratinocytes / H. Randolph Byers -- The regulation of melanin formation / Vincent J. Hearing -- The tyrosinase gene family / William S. Oetting & Vijayasaradhi Setaluri -- Molecular regulation of melanin formation: melanosome transporter proteins / Murray H. Brilliant -- Transcriptional regulation of melanocyte function / Kazuhisa Takeda & Shigeki Shibahara -- Enzymology of melanin formation / Francisco Solano & José C. García-Borrón -- Chemistry of melanins / Shosuke Ito & Kazumasa Wakamatsu -- The physical properties of melanins / Tadeusz Sarna & Harold A. Swartz -- Photobiology of melanins / Antony R. Young -- Toxicological aspects of melanin and melanogenesis / Edward J. Land, Christopher A. Ramsden & Patrick A. Riley -- Regulation of pigment type switching by agouti, melanocortin signaling, attractin, and mahoganoid / Gregory S. Barsh -- Human pigmentation: its regulation by ultraviolet light and by endocrine, paracrine and autocrine factors / Zalfa Abdel-Malek & Ana Luisa Kadekaro -- Paracrine interactions of melanocytes in pigmentary disorders / Genji Imokawa -- Growth factor receptors and signal transduction regulating the proliferation and differentiation of melanocytes / Ruth Halaban & Gisela Moellmann -- Aging and senescence of melanocytes / Debdutta Bandyopadhyay & Estela E. Medrano -- The genetics of melanoma / Vanessa C. Gray-Schopfer & Dorothy C. Bennett -- The transformed phenotype of melanocytes / Dong Fang & Meenhard Herlyn -- A more precise lexicon for pigmentation, pigmentary disorders, and "chromatic" abnormalities / James J. Nordlund ... [et al.] -- The normal color of human skin / James J. Nordlund & Jean-Paul Ortonne -- Mechanisms that cause abnormal skin color / Jean-Paul Ortonne & James J. Nordlund -- Genetic hypomelanoses: disorders characterized by congenital white spotting-piebaldism, Waardenburg syndrome, and related genetic disorders of melanocyte development-clinical aspects / Richard A. Spritz -- Genetic hypomelanoses: acquired depigmentation -- Genetic hypomelanoses: generalized hypopigmentation -- Genetic hypomelanoses: localized hypopigmentation -- Genetic hypomelanoses: disorders characterized by hypopigmentation of hair -- Metabolic, nutritional and endocrine disorders -- Chemical, pharmacologic and physical agents causing hypomelanoses -- Infectious hypomelanoses / Jean-Philippe Lacour-- Inflammatory hypomelanoses / Jean-Philippe Lacour -- Hypomelanoses associated with melanocytic neoplasia / Lieve Brochez, Barbara Boone, & Jean-Marie Naeyaert -- Miscellaneous hypomelanoses: depigmentation -- Miscellaneous hypomelanoses: hypopigmentation -- Miscellaneous hypomelanoses: extracutaneous loss of pigmentation -- Hypochromia without hypomelanosis / Jean-Philippe Lacour -- Genetic epidermal syndromes: disorders characterized by generalized hyperpigmentation -- Genetic epidermal syndromes: disorders characterized by reticulated hyperpigmentation -- Genetic epidermal syndromes with Café-au-Lait macules -- Genetic epidermal pigmentation with lentigines -- Genetic epidermal syndromes: localized hyperpigmentation -- Genetic epidermal syndromes: disorders of aging -- Congenital epidermal hypermelanoses -- Acquired epidermal hypermelanoses -- Hypermelanosis associated with gastrointestinal disorders -- Acquired and congenital dermal hypermelanosis -- Mixed epidermal and dermal hypermelanoses and hyperchromias -- Drug-induced or -related pigmentation -- The melanocyte system of the nails and its disorders -- Pigmentary abnormalities and discolorations of the mucous membranes / John C. Maize, Jr. & John C. Maize, Sr. -- Common benign neoplasms of melanocytes -- Rare benign neoplasms of melanocytes -- Topical treatment of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- Chemophototherapy of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- UVB therapy for pigmentary disorders / Thierry Passeron & Jean-Paul Ortonne -- Sunscreens and cosmetics / James J. Nordlund & Rebat M. Halder -- Surgical treatments of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- Laser treatment of pigmentary disorders / Rebat M. Halder, Lori M. Hobbs, & James J. Nordlund.
  • "Millions of people use Pilates training to improve health and fitness, or regain movement capability following injury or disease. Competent, professional support from physiotherapists, sports teachers and trainers is of vital importance for every client or patient. "Pilates: A teachers' manual“ provides you, as a professional, with fundamental teaching structures and practical guidelines. The concepts which characterized the traditional approach to Pilates are combined with the evolved methods of modern Pilates training, and backed up by current findings in sports science and kinesiology."--Publisher's website.
  • Statistical analysis of pineal tumors based on the data of brain tumor registry of Japan / Shibui, S., Nomura, K. -- Pathology of pineal parenchymal tumors / Sato, K., Kubota, T. -- Occipital transtentorial approach and combined treatments for pineal parenchymal tumors / Tsumanuma, I., Tanaka, R., Fujii, Y. -- Role of stereotactic radiosurgery in the management of pineal parenchymal tumors -- Kano, H. ... [et al.] -- Pathology of intracranial germ cell tumors / Sato, K., Takeuchi, H., Kubota, T. -- Pineal germ cell tumors / Matsutani, M. -- Strategy of combined treatment of germ cell tumors / Sawamura, Y. -- Radiation therapy for intracranial germ cell tumors / Aoyama, H. -- Stereotactic radiosurgery for pineal and related tumors / Mori, Y. ... [et al.] -- Management of central nervous system germinoma : proposal for a modern strategy / Shibamoto, Y. -- Quality of life of extremely long-time germinoma survivors mainly treated with radiotherapy / Sugiyama, K. ... [et al.].
  • "The first half of the book provides historical review, insights into the barriers women physicians face and the authors' roles promoting women in medicine. The second half focuses on authors' interactions with pioneering women in medicine or biographies about influential women physicians and scientists."--Preface.
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    This book is a history of cardiac surgery in the words of the first generation of surgeons. Heart operations today are quite common and relatively low-risk, but in the beginning it was just the opposite. Cardiac operations were reserved for desperately ill patients. The author documents this dramatic transition with profiles of 38 surgeons who were active between 1940 and 1985. The profiles are edited transcripts of interviews videotaped between 1996 and 2004. They tell of the development of new techniques such as the "blue baby operation," the first heart-lung machine, the first artificial heart valve, and the first coronary bypass operation. They also tell the unusual life stories of the surgeons and allude to professional and institutional rivalries. A particularly valuable part of the book is the author's brief history of cardiac surgery, designed to orient the reader for reading the profiles that follow. - Publisher.
  • The practice of diagnostic radiology has become increasingly complex, with the use of numerous imaging modalities and division into many subspecialty areas. It is becoming ever more difficult for subspecialist radiologists, general radiologists, and residents to keep up with the advances that are occurring year on year, and this is particularly true for less familiar topics. Failure to appreciate imaging pitfalls often leads to diagnostic error and misinterpretation, and potential medicolegal problems. Diagnostic errors may be due to various factors such as inadequate imaging technique, imaging artifacts, failure to recognize normal structures or variants, lack of correlation with clinical and other imaging findings, and poor training or inexperience. Many, if not most, of these factors are potentially recognizable, preventable, or correctable. This textbook, written by experts from reputable centers across the world, systematically and comprehensively highlights the pitfalls that may occur in diagnostic radiology. Both pitfalls specific to different modalities and techniques and those specific to particular organ systems are described with the help of numerous high-quality illustrations. Recognition of these pitfalls is crucial in helping the practicing radiologist to achieve a more accurate diagnosis.
  • Why it matters -- Tackling hospital-acquired infections -- Moving closer to the patient -- Reducing medication errors -- Eliminating the wait -- Applying best practices -- Transforming a medical specialty.
  • Pituitary apoplexy 2014
    Pituitary apoplexy is a rare and life-threatening complication that occurs in 0.6-10.5% of all patients with pituitary adenomas. Unfortunately, pituitary apoplexy is often misdiagnosed before surgery. Furthermore, in spite of all the advances in imaging techniques and therapeutic methods, its optimal management is still controversial owing to the limited individual experience and the very variable clinical course of the condition, which ranges from asymptomatic to critical illness with visual loss and subarachnoid hemorrhage. The management of visual dysfunction in particular remains a subject of debate. This book provides an in-depth review of knowledge of the management of pituitary apoplexy, with an emphasis on clinical and neuroradiological findings and treatment modalities, medical and surgical. In addition, it supplies clinicians and investigators with detailed information on current evidence and considers future areas of investigation and innovative therapeutic philosophies. Both the editors and the authors are leading international authorities in the field.
  • Section 1: overview. The endocrine system / Sylvia L Asa, Shereen Ezzat ; Signs and symptoms of pituitary disease / Eva Fernandez-Rodriguez, Ignacio Bernabeu, Felipe F Casanueva, Eva N Kassi, Gregory A Kaltsas, George P Chrousos, Valerie Golden -- Section 2: disorders. Acromegaly / Shereen Ezzat ; Secondary adrenal insufficiency / Tobias Else, Richard J Auchus ; Adult growth hormone deficiency / T Brooks Vaughan, Kristen Owen Riley, Lewis S Blevins ; Pituitary carcinoma / Sylvia L Asa ; Craniopharyngioma / Jessica K Devin ; Cushing's syndrome / Lewis S Blevins ; Empty sella syndrome / Michael C Oh, Manish K Aghi ; Familial pituitary adenomas / Laura C Hernández-Ramírez, Márta Korbonits ; Follicle stimulating hormone and luteinizing hormone secreting tumors / Bahram Khazai, Ronald S Swerdloff, Christina Wang ; Hypopituitarism / Klara J Rosenquist, Ursula B Kaiser ; Clinically nonfunctioning pituitary adenomas / Brandon A Miller, Adriana G Ioachimescu, Nelson M Oyesiku ; Prolactinoma / Luis G Sobrinho ; Rathke's cleft cysts / Seunggu J Han, Arman Jahangiri, Manish K Aghi ; Thyroid hormone deficiency / Whitney W Woodmansee ; Thyroid stimulating hormone secreting tumor / Andrea Lania, Luca Persani, Paolo Beck-Peccoz ; Pituitary disorders - specific issues for women / Maria Fleseriu, Christine G Yedinak, Jessica Brzana, Shirley McCartney ; Hypogonadism and male sexual function / Prasanth N Surampudi, Christina Wang, Ronald S Swerdloff ; Pituitary disorders specific to children / Kathryn Pade, Mitchell E Geffner -- Section 3: diagnosing pituitary disorders. Physical examination / Laurence Katznelson ; Pituitary endocrine function testing / Shereen Ezzat -- Section 4: treatment of pituitary disorders. Medical management of pituitary adenomas / Paolo Cappabianca, Daniel M Prevedello, Michelangelo de Angelis, Andressa Bornschein, Leo F S Ditzel Filho, Domenico Solari, Ricardo L Carrau, Felice Esposito, Danielle de Lara, Luigi M Cavallo, Annamaria Colao ; Surgical management of pituitary disorders / Gautam U Mehta, John A Jane, Ian F Dunn, Tong Yang, Theodore H Schwartz, Huy T Duong, Daniel F Kelly ; Stereotactic radiosurgery for pituitary adenomas / Brian J Williams, Stephen J Monteith, Jason P Sheehan ; Hormone replacement therapy / Joseph A M J L Janssen, Aart Jan van der Lely, Alan D Rogol, Adriana G Ioachimescu -- Section 5: complications that accompany pituitary disease. Complications of pituitary disease / Ludovica F S Grasso, Alessia Cozzolino, Annamaria Colao, Krystallenia I Alexandraki, Gregory A Kaltsas, George P Chrousos, Marco Faustini-Fustini, Giorgio Frank, Paul B Rizzoli, Andrea L Utz, Sashank Prasad -- Section 6: general psychological and psychosocial effects. General psychological and psychosocial effects of pituitary disorders / Valerie Golden -- Section 7: long term: what you and your patients can expect. Living with pituitary disease / Jessica K Devin -- Section 8: research and clinical trials. Research and clinical trials / Brittany P Sumerel, Anthony P Heaney -- Section 9: resources. Fundamentals of pituitary pathology / Sylvia L Asa -- Glossary -- Index.
  • Role of transcranial approaches in the treatment of sellar and suprasellar lesions / Maartens, N.F.; Kaye, A.H -- Extended transsphenoidal approach / Dumont, A.S. ... [et al.] -- Image guidance in pituitary surgery / Asthagiri, A.R.; Laws, E.R. Jr.; Jane, J.A. Jr. -- Endoscopic endonasal cavernous sinus surgery, with special reference to pituitary adenomas / Frank, G.; Pasquini, E. -- Diagnosis and management of pediatric sellar lesions / Jagannathan, J.; Dumont, A.S.; Jane, J.A. Jr. -- The craniopharyngioma / Oskouian, R.J.; Samii, A.; Laws, E.R. Jr. -- Rathke's cleft cysts / Kanter, A.S. ... [et al.] -- Treatment of Cushing's disease : a retrospective clinical study of the latest 100 cases / Hofmann, B.M.; Fahlbusch, R. -- Stereotactic radiosurgery for pituitary adenomas : a review of the literature and our experience / Sheehan, J.P. ... [et al.] -- Neuropathological considerations of pituitary adenomas / Asthagiri, A.; Lopes, M.B.S. -- Anesthetic and critical care management of patients undergoing pituitary surgery / Burton, C.M.; Nemergut, E.C. -- Vascular injury and transsphenoidal surgery / Oskouian, R.J.; Kelly, D.F.; Laws, E.R. Jr.
  • Update on basic and clinical research on pituitary function and disease.
  • Implication of pituitary tropic status on tumor development / I. Donangelo, S. Melmed -- Anterior pituitary cell renewal during the estrous cycle / M. Candolfi ... [et al.] -- Bone morphogenetic protein-4 control of pituitary pathophysiology / D. Giacomini ... [et al.] -- Genesis of prolactinomas: studies using estrogen-treated animals / D.K. Sarkar -- Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma / C. Cristina ... [et al.] -- Vasoinhibins: a family of n-terminal prolactin fragments that inhibit angiogenesis and vascular function / C. Clapp ... [et al.] -- Molecular mechanisms of pituitary differentiation and regulation: implications for hormone deficiencies and hormone resistance syndromes / J. Drouin -- Long-term follow-up of prolactinomas: should dopamine agonist treatment be life-long? / M. Guitelman -- Ghrelin: from somatotrope secretion to new perspectives in the regulation of peripheral metabolic functions / F. Broglio ... [et al.] -- Regulating of growth hormone sensitivity by sex steroids: implications for therapy / K.K.Y. Ho ... [et al.] -- Acromegaly: molecular expression of somatostatin receptor subtypes and treatment outcome / M.D. Bronstein -- Gene therapy in the neuroendocrine system / C.B. Hereñú ... [et al.] -- Ectopic ACTH syndrome / A.M. Isidori, G.A. Kaltsas, A.B. Grossman -- Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function / A.F. De Nicola ... [et al.] -- New aspects in the diagnosis and treatment of Cushing disease / M. Labeur ... [et al.].
  • Pituitary. 3rd ed. 2011
    2011 ClinicalKey
    Chapter 1. Pituitary Development / Jacques Drouin -- Chapter 2. Hypothalamic Regulation of Anterior Pituitary Function / Anat Ben-Shlomo, Shlomo Melmed -- Chapter 3. Adrenocorticotropin / Oulu Wang, Joseph A. Majzoub -- Chapter 4. Growth Hormone / Vivien S. Herman-Bonert, Shlomo Melmed -- Chapter 5. Prolactin / Mary P. Gillam, Mark E. Molitch -- Chapter 6. Thyroid-stimulating Hormone / Virginia D. Sarapura, David F. Gordon, Mary H. Samuels -- Chapter 7. Gonadotropin Hormones / Ursula B. Kaiser -- Chapter 8. The Posterior Pituitary / Daniel G. Bichet -- Chapter 9. The Hypothalamus / Glenn D. Braunstein -- Chapter 10. Anterior Pituitary Failure / John D. Carmichael -- Chapter 11. Pituitary Function in Systemic Disorders / Harold E. Carlson -- Chapter 12. The Pituitary Gland in Pregnancy and the Puerperium / Harold E. Carlson -- Chapter 13. Drugs and Pituitary Function / Harold E. Carlson -- Chapter 14. Acromegaly / Shlomo Melmed -- Chapter 15. Prolactinoma / Mary P. Gillam, Mark E. Molitch -- Chapter 16. Cushing's disease / Xavier Bertagna, Laurence Guignat, Marie-Charles Raux-Demay, Brigitte Guilhaume, François Girard -- Chapter 17. Thyrotropin-Secreting Pituitary Tumors / Vanessa Rouach, Yona Greenman -- Chapter 18. Gonadotroph Adenomas / Peter J. Snyder -- Chapter 19. Nonpituitary Tumors of the Sellar Region / Olga Moshkin, Steffen Albrecht, Juan M. Bilbao, Kalman Kovacs -- Chapter 20. Pituitary Imaging / Marcel M. Maya, Barry D. Pressman -- Chapter 21. Pituitary Surgery / Rudolf Fahlbusch, Michael Buchfelder.
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    Pivot table fundamentals and ground rules -- Creating your first pivot table -- Customizing your pivot table -- Controlling the way you view your pivot data -- Performing calculations within your pivot tables -- Creating and using pivot charts -- Analyzing disparate data sources with pivot tables -- Taking your pivot tables to the web -- Working with and analyzing olap data sources -- Enhancing pivot reports with macros -- Using vba to create pivot tables -- Common pivot table issues and questions -- A pivot table function map.
  • The history of public health has focused on direct relationships between problems and solutions: vaccinations against diseases, ad campaigns targeting risky behaviors. But the accelerating pace and mounting intricacies of our lives are challenging the field to find new scientific methods for studying community health. The complexities of place (COP) approach is emerging as one such promising method. ℗ℓ Place and Health as Complex Systems demonstrates how COP works, making an empirical case for its use in for designing and implementing interventions. This brief resource reviews the defining characteristics of places as dynamic and evolving social systems, rigorously testing them as well as the COP approach itself. The study, of twenty communities within one county in the Midwest, combines case-based methods and complexity science to determine whether COP improves upon traditional statistical methods of public health research. Its conclusions reveal strengths and limitations of the approach, immediate possibilities for its use, and challenges regarding future research. Included in the coverage: ℗ℓ Characteristics of places and the complexities of place approach. The Definitional Test of Complex Systems. Case-based modeling using the SACS toolkit. Methods, maps, and measures used in the study. Places as nodes within larger networks. Places as power-based conflicted negotiations. ℗ℓ Place and Health as Complex Systems brings COP into greater prominence in public health research, and is also valuable to researchers in related fields such as demography, health geography, community health, urban planning, and epidemiology. ℗ℓ
  • Placebo 2014
    Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be held in Tuebingen (Germany) in January 2013, and where the most prominent researchers in this field will present and exchange their ideas. The authors who will be invited to write chapters for this volume will be the very same speakers at this meeting, thus guaranteeing high standard and excellence in the topic that will be treated. The approach of the book is mainly pharmacological, including basic research and clinical trials, and the contents range from different medical conditions and systems, such as pain and the immune system, to different experimental approaches, like in vivo receptor binding and pharmacological/behavioral conditioning. Overall, the volume will give an idea of modern placebo research, of timely concepts in both experimental and clinical pharmacology, as well as of modern methods and tools in neuroscience.
  • 1. Historical aspects of placebo analgesia / Damien Finniss -- 2. Neurochemistry of placebo analgesia : opioids, cannabinoids and cholecystokinin / Fabrizio Benedetti, Elisa Frisaldi -- 3. Placebo analgesia in rodents / Jian-You Guo, Jin-Yan Wang, Fei Luo -- 4. Molecular mechanisms of placebo responses in humans / Marta Pecina, Jon-Kar Zubieta -- 5. How does EEG contribute to our understanding of the placebo response? / Anthony Jones, Christopher Brown, Wael El-Deredy -- 6. Spinal mechanisms of placebo analgesia and nocebo hyperalgesia : descending inhibitory and facilitatory influences / Serge Marchand -- 7. Spinal and supraspinal mechanisms of placebo analgesia / Falk Eippert, Christian Buchel -- 8. Positive and negative emotions and placebo analgesia / Magne Arve Flaten, Per M. Aslaksen, Peter S. Lyby -- 9. Placing placebo in normal brain function with neuroimaging / Martin Ingvar, Predrag Petrovic, Karin Jensen -- 10. Brain predictors of individual differences in placebo responding / Leonie Koban, Luka Ruzic, Tor D. Wager -- 11. Placebo responses, antagonistic responses, and homeostasis / Magne Arve Flaten -- 12. Placebo analgesia, nocebo hyperalgesia, and acupuncture / Jian Kong, Randy L. Gollub -- 13. The relevance of placebo and nocebo mechanisms for analgesic treatments / Ulrike Bingel -- 14. How placebo responses are formed : from bench to bedside / Luana Colloca -- 15. Methodologic aspects of placebo research / Magne Arve Flaten, Karin Meissner, Luana Colloca -- 16. Balanced placebo design, active placebos, and other design features for identifying, minimizing and characterizing the placebo response / Paul Enck, Katja Weimer, Sibylle Klosterhalfen -- 17. Psychological processes that can bias responses to placebo treatment for pain / Ben Colagiuri, Peter F. Lovibond -- 18. Against 'placebo' : the case for changing our language, and for the meaning response / Daniel E. Moerman -- 19. Placebo effects in complementary and alternative medicine : the self-healing response / Harald Walach -- 20. Conceptualizations and magnitudes of placebo analgesia effects across meta-analyses and experimental studies / Lene Vase, Gitte Laue Petersen -- 21. The contribution of desire, expectation, and reduced negative emotions to placebo anti-hyperalgesia in irritable bowel syndrome / Donald D. Price, Lene Vase -- 22. The wound that heals : placebo, pain and surgery / Wayne B. Jonas [and three others] -- 23. What are the best placebo interventions for the treatment of pain? / Karin Meissner, Klaus Linde -- 24. How communication between clinicians and patients may impact pain perception / Arnstein Finset -- 25. Nocebos in daily clinical practice / Bettina K. Doering, Winfried Rief -- 26. The potential of the analgesic placebo effect in clinical practice -- recommendations for pain management / Regine Klinger, Herta Flor -- 27. Placebo and nocebo : ethical challenges and solutions / Luana Colloca, Franklin G. Miller.
  • v. 2 Springer Protocols
  • "This is the first systematic scholarly study of the Ottoman experience of plague during the Black Death pandemic and the centuries that followed. Using a wealth of archival and narrative sources, including medical treatises, hagiographies, and travelers' accounts, as well as recent scientific research, Nükhet Varlik demonstrates how plague interacted with the environmental, social, and political structures of the Ottoman Empire from the late medieval through the early modern era. The book argues that the empire's growth transformed the epidemiological patterns of plague by bringing diverse ecological zones into interaction and by intensifying the mobilities of exchange among both human and non-human agents. Varlik maintains that persistent plagues elicited new forms of cultural imagination and expression, as well as a new body of knowledge about the disease. In turn, this new consciousness sharpened the Ottoman administrative response to the plague, while contributing to the makings of an early modern state"-- Provided by publisher.
  • History, classification and cultivation of the planctomycetes / Cheryl Jenkins and James T. Staley -- Cell compartmentalization and endocytosis in planctomycetes: structure and function in complex bacteria / John A. Fuerst, Richard I. Webb, and Evgeny Sagulenko -- Structural aspects of MC proteins of PVC superphylum members / Damien P. Devos -- Cell biology of anaerobic ammonium-oxidizing bacteria: unique prokaryotes with an energy-conserving intracellular compartment / Sarah Neumann, Muriel C.F. van Teeseling and Laura van Niftrik -- Acidophilic planctomycetes: expanding the horizons of new planctomycete diversity / Svetlana N. Dedysh and Irina S. Kulichevskaya -- Toward the development of genetic tools for Planctomycetes / Mareike Jogler and Christian Jogler -- Genomics and bioinformatics of the PVC superphylum / Olga K. Kamneva, Daniel H. Haft, Stormy J. Knight, Davide A. Liberles, and Naomi L. Ward -- Distribution and evolution of C1 transfer enzymes and evolution of the planctomycetes / Ludmila Chistoserdova -- Unusual members of the PVC superphylum: the methanotrophic Verrucomicrobia genus "Methylacidiphilum" / Christine E. Sharp, Huub J.M. Op den Camp, Ivica Tamas, and Peter F. Dunfield -- Phyla related to Planctomycetes: members of phylum Chlamydiae and their implications for Planctomycetes cell biology / Claire Bertelli and Gilbert Greub -- Planctomycetes: their evolutionary implications for models for origins of eukaryotes and the eukaryote nucleus and endomembranes / John A. Fuerst and Evgeny Sagulenko -- Final word: the future of planctomycetology and related studies / John A. Fuerst -- Index.
  • Print Material
  • The EMBL nucleotide sequence and genome reviews databases / Peter Sterk ... [et al.] -- Using GenBank / David Wheeler -- A collection of plant-specific genomic data and resources at NCBI / Tatiana Tatusova, Brian Smith-White, and James Ostell -- UniProtKB/Swiss-Prot / Emmanuel Boutet ... [et al.] -- Plant database resources at The Institute for Genomic Research / Agnes P. Chan... [et al.] -- MIPS plant genome information resources / Manuel Spannagl ...[et al.] -- HarvEST / Timothy J. Close ... [et al.] -- The TAIR database / Rebecca L. Poole -- AtEnsEMBL / Nick James ... [et al.] -- Accessing integrated Brasica genetic and genomic data using the BASC server / Christopher G. Love and David Edwards -- Leveraging model legume information to find candidate genes for soybean sudden death syndrome using the Legume Information System / Michael D. Gonzales ... [et al.] -- Legume resources : MtDB and / Ernest F. Retzel ... [et al.] -- BGI-RIS V2 / Ximiao He and Jun Wang -- GrainGenes / Helen O'Sullivan -- Gramene / Doreen Ware -- MaizGDB / Carolyn J. Lawrence -- BarleyBase/PLEXdb / Roger P. Wise ... [et al.] -- Reaping the benefits of SAGE / Stephen J. Robinson ... [et al.] -- Methods for analysis of gene expression in plants using MPSS / Kan Nobuta, Kalyan Vemaraju, and Blake C. Meyers -- Metabolomics data analysis, visualization, and integration / Lloyd W. Sumner, Ewa Urbanczyk-Wochniak, and Corey D. Broeckling -- KEGG bioinformatics resource for plant genomics research / Ali Masoudi-Nejad ... [et al.] -- International Crop Information System for germplasms data management / Arllet Portugal ... [et al.] -- Automated discovery of single nucleotide polymorphism and simple sequence repeat molecular genetic markers / Jacqueline Batley, Erica Jewell, and David Edwards -- Methods for gene ontology annotation / Emily Dimmer ... [et al.] -- Gene structure annotation at PlantGDB / Volker Brendel -- An introduction to BioPerl / Jason E. Stajich.
  • Plant tissue cultures / Anna Karkonen [and others] -- Computerized molecular modeling of carbohydrates / Alfred D. French and Glenn P. Johnson -- Oligosaccharide mass profiling (OLIMP) of cell wall polysaccharides by MALDI-TOF/MS / Markus Gunl, Florian Kraemaer, and Markus Pauly -- High-voltage paper electrophoresis (HVPE) of cell-wall building blocks and their metabolic precursors / Stephen C. Fry -- Carbohydrate gel electrophoresis / Florence Goubet, Paul Dupree, and Katja Salomon Johansen -- Monoclonal antibodies, carbohydrate-binding modules, and the detection of polysaccharides in plant cell walls / Cecile Herve, Susan E. Marcus, and J. Paul Knox -- Screening and characterization of plant cell walls using carbohydrate microarrays / Iben Sorensen and William G.T. Willats -- Electron tomography and immunogold labelling as tools to analyse de novo assembly of plant cell walls / Marisa S. Otegui -- Analysing cellulose biosynthesis with confocal microscopy / Meera Nair and Seth DeBolt -- Visual mapping of cell wall biosynthesis / Yumiko Sakuragi, Morten H.H. Norholm, and Henrick V. Scheller -- Atomic force microscopy of plant cell walls / Andrew R. Kirby -- Using solid-state 13C NMR spectroscopy to study the molecular organization of primary plant cell walls / Tracey J. Bootten [and others] -- Formation of cellulose-based composites with hemicelluloses and pectins using gluconacetobacter fermentation / Deirdre Mikkelsen and Michael J. Gidley -- Structural proteins of the primary cell wall : extraction, purification, and analysis / Derek T.A. Lamport, Li Tan, and Marcia J. Kieliszewski -- New insights into the control of cell growth / Claudia Blaukopf, Matthaus Z. Krol, and Georg J. Seifert -- Extraction and detection of Arabinogalactan proteins / Zoe A. Popper -- Characterization of plant cell wall proteome using high-throughput screens / Sang-Jik Lee and Jocelyn K.C. Rose -- Knocking out the wall : protocols for gene targeting in Physcomitrella patens / Alison W. Roberts [and others] -- Measuring in vitro extensibility of growing plant cell walls / Daniel J. Cosgrove.
  • Plant chromosome engineering 2011
    Springer Protocols
    Recent advances in plant transformation -- Engineering the plastid genome of nicotiana sylvestris, a diploid model species for plastid genetics -- Homologous recombination in plants : An antireview -- Chromosome painting for plant biotechnology -- Plant B chromosomes -- Telomere truncation in plants -- Engineered plant minichromosomes -- Method for bxb1-mediated site-specific integration in planta -- Targeted mutagenesis in arabidopsis using zinc-finger nucleases -- Vectors and methods for hairpin RNA and artificial microRNA-mediated gene silencing in plants -- Recombinant protein expression in nicotiana -- Chromosome analysis and sorting using flow cytometry -- Super-stretched pachytene chromosomes for plant molecular cytogenetic mapping -- Cytological dissection of the triticeae chromosomes by the gametocidal system -- Development and use of oat-maize chromosome additions and radiation hybrids -- Enhancer trapping in plants -- Chromatin beacons : Global sampling of chromatin physical properties using chromatin charting lines -- Transposable elements as catalysts for chromosome rearrangements.
  • Growth protocols for model plants in developmental biology / Lars Hennig -- Grafting as a research tool / Colin G.N. Turnbull -- Virus-induced gene silencing as a reverse genetics tool to study gene function / Steven Bernacki ... [et al.] -- The CRE/lox system as a tool for developmental studies at the cell and tissue level / Guy Wachsman and Renze Heidstra -- Inducible gene expression systems for plants / Lorenzo Borghi -- Trichome development in Arabidopsis / Joachim F. Uhrig and Martin Hülskamp -- Phenotyping the development of leaf area in Arabidopsis thaliana / Sarah J. Cookson ... [et al.] -- Analyzing shoot apical meristem development / Cristel C. Carles ... [et al.] -- Analyzing floral meristem development / Elisa Fiume ... [et al.] -- Female gametophytic mutants : diagnosis and characterization / Ronny Völz and Rita Gross-Hardt -- Pollen tube development / Mark A. Johnson and Benedikt Kost -- Analysis of root meristem size development / Serena Perilli and Sabrina Sabatini -- Phenotypic characterization of photomorphogenic responses during plant development / Thomas Kretsch -- Kinematic analysis of cell division and expansion / Bart Rymen ... [et al.] -- Flowering time control / Yvonne Möller-Steinbach, Cristina Alexandre, and Lars Hennig -- mRNA detection by whole mount in situ hybridization (WISH) or sectioned tissue in situ hybridization (SISH) in Arabidopsis / Yvonne Stahl and Rüdiger Simon -- Immunolocalization of proteins in plants / Michael Sauer and Jiří Friml -- Detection of small non-coding RNAs / Tamas Dalmay -- Quantitative real time PCR in plant developmental biology / Vivien Exner -- Luciferase and green fluorescent protein reporter genes as tools to determine protein abundance and intracellular dynamics / András Viczián and Stefan Kircher -- Fluorescence-activated cell sorting in plant developmental biology / Anjali S. Iyer-Pascuzzi and Philip N. Benfey -- Laser microdissection of paraffin-embedded plant tissues for transcript profiling / Robert C. Day -- Utilizing bimolecular fluorescence complementation (BiFC) to assay protein-protein interaction in plants / Nir Ohad and Shaul Yalovsky -- The split luciferase complementation assay / Naohiro Kato and Jason Jones -- Co-immunoprecipitation and protein blots / Erika Isono and Claus Schwechheimer -- Probing protein-protein interactions with FRET-FLIM / Christoph Bücherl ... [et al.] -- Plant chromatin immunoprecipitation / Corina B.R. Villar and Claudia Köhler -- Immunocytological analysis of chromatin in isolated nuclei / Penka Pavlova ... [et al.] -- Bisulphite sequencing of plant genomic DNA / Ernst Aichinger and Claudia Köhler.
  • Zygotic embryo culture : an overview / Tegan M. Haslam and Edward C. Yeung -- In vitro fertilization with rice gametes: production of zygotes and zygote and embryo culture / Takashi Okamoto -- Canola zygotic embryo culture / Nicole S. Ramesar-Fortner and Edward C. Yeung -- Immature seeds and embryos of Medicago truncatula cultured in vitro / Sergio J. Ochatt -- In vitro culture and germination of terrestrial asian orchid seeds / Yung-I. Lee -- In vitro culture of coconut (Cocos nucifera L.) zygotic embryos / Florent Engelmann, Bernard Malaurie, and Oulo N'Nan -- Immature embryo rescue and culture / Xiuli Shen, Fred G. Gmitter, Jr., and Jude W. Grosser -- Chickpea hybridization using in vitro techniques / Nalini Mallikarjuna and Fred J. Muehlbauer -- Muskmelon embryo rescue techniques using in vitro embryo culture / Hector Gordon Nunez-Palenius, Rafael Ramirez-Malagon, and Neftali Ochoa-Alejo -- Phaseolus immature embryo rescue technology / Pascal Geerts ... [et al.] -- Wide crossing in lentil through embryo rescue / Richard Fratini and Maria L. Ruiz -- Generation of interspecific hybrids of Trifolium using embryo rescue techniques / Ajoy Kumar Roy, Devendra Ram Malaviya and Pankaj Kaushal -- Cryopreservation of embryos : an overview / Florent Engelmann -- Cryogenic technologies for the long-term storage of Citrus germplasm / Anna De Carlo, Maurizio Lambardi, and Elif Aylin Ozudogru -- Cryopreservation of zygotic embryonic axes and somatic embryos of european chestnut / Ana M. Vieitez, M. Carmen San-Jose and Elena Corredoira -- Cryopreservation of Ilex immature zygotic embryos / Luis Mroginski ... [et al.] -- Use of zygotic embryos as explants for in vitro propagation : an overview / Mohamed Elhiti and Claudio Stasolla -- Somatic embryogenesis and plant regeneration in the culture of Arabidopsis thaliana (L.) heynh. immature zygotic embryos / Malgorzata D. Gaj -- Pine somatic embryogenesis using zygotic embryos as explants / Gerald S. Pullman and Kylie Bucalo -- Micropropagation of Phalaenopsis orchids via protocorms and protocorm-like bodies / Kee Yoeup Paek, Eun Joo Hahn, and So Young Park -- Genetic transformation protocols using zygotic embryos as explants : an overview / Muhammad Tahir, Ejaz A. Waraich, and Claudio Stasolla -- Genetic transformation using maize immature zygotic embryos / Bronwyn Frame ... [et al.] -- Biolistic-mediated transformation protocols for maize and pearl millet using pre-cultured immature zygotic embryos and embryogenic tissue / Martha M. O'Kennedy, Hester C. Stark and Nosisa Dube -- Agrobacterium tumefaciens-mediated genetic transformation of cereals using immature embryos / Ashok K. Shrawat and Allen G. Good.
  • Plant embryogenesis 2008
    Springer Protocols
    Arabidopsis embryogenesis / Soomin Park and John J. Harada -- Maize embryogenesis / Pilar Fontanet and Carlos M. Vicient -- Spruce embryogenesis / Sara von Arnold and David Clapham -- In vitro fertilization with isolated higher plant gametes / Erhard Kranz, Yoichiro Hoshino, and Takashi Okamoto -- In vitro culture of Arabidopsis embryos / Michael Sauer and Jiří Friml -- Culture and time-lapse tracking of barley microspore-derived embryos / Simone de F. Maraschin ... [et al.] -- Isolation of embryo-specific mutants in Arabidopsis : plant transformation / Nai-You Liu, Zhi-Feng Zhang, and Wei-Cai Yang -- Isolation of embryo-specific mutants in Arabidopsis : genetic and phenotypic analysis / Nai-You Liu, Zhi-Feng Zhang, and Wei-Cai Yang -- Laser-capture microdissection to study global transcriptional changes during plant embryogenesis / Stuart A. Casson, Matthew W.B. Spencer, and Keith Lindsey -- Promoter trapping system to study embryogenesis / Robert Blanvillain and Patrick Gallois -- Visualization of auxin gradients in embryogenesis / Michael Sauer and Jiří Friml -- Intercellular trafficking of macromolecules during embryogenesis / Insoon Kim and Patricia C. Zambryski -- Immunolocalization of proteins in somatic embryos : applications for studies on the cytoskeleton / Andrei P. Smertenko and Patrick J. Hussey -- Detection of programmed cell death in plant embryos / Lada H. Filonova, María F. Suárez, and Peter V. Bozhkov.
  • Plant genomes 2008
    Paleopolyploidy and its impact on the structure and function of modern plant genomes / A.H. Paterson -- Genomic history and gene family evolution in angiosperms: challenges and opportunities / J. Sampedro, D. Cosgrove -- The evolutionary position of subfunctionalization, downgraded / M. Freeling -- Grass genome structure and evolution / J. Messing, J.L. Bennetzen -- Phylogenetic insights into the pace and pattern of plant genome size evolution / C.E. Grover, J.S. Hawkins, J.F. Wendel -- Plant transposable elements / J.M. Deragon, J.M. Casacuberta, O. Panaud -- Plant sex chromosomes / D. Charlesworth -- Plant centromeres / J.C. Lamb ... [et al.] -- MiRNAs in the plant genome: all things great and small / B.C. Meyers, P.J. Green, C. Lu -- Recent insights into the evolution of genetic diversity of maize / A. Rafalski, S. Tingey -- The rice genome structure as a trail from the past to beyond / T. Sasaki.
  • Role of model plant species / Richard Flavell -- New technologies for ultra-high throughput genotyping in plants / Nikki Appleby, David Edwards, and Jacqueline Batley -- Genetic maps and the use of synteny / Chris Duran, David Edwards, and Jacqueline Batley -- A simple TAE-based method to generate large insert BAC libraries from plant species / Bu-Jun Shi, J. Perry Gustafson, and Peter Langridge -- Transcript profiling and expression level mapping / Elena Potokina, Arnis Druka, and Michael J. Kearsey -- Methods for functional proteomic analyses / Christof Rampitsch and Natalia V. Bykova -- Stable transformation of plants / Huw D. Jones and Caroline A. Sparks -- Transient transformation of plants / Huw D. Jones, Angela Doherty, and Caroline A. Sparks -- Bridging the gene-to-function knowledge gap through functional genomics / Stephen J. Robinson and Isobel A.P. Parkin -- Heterologous and cell-free protein expression systems / Naser Farrokhi ... [et al.] -- Functional genomics and structural biology in the definition of gene function / Maria Hrmova and Geoffrey B. Fincher -- In situ analysis of gene expression in plants / Sinéad Drea ... [et al.] -- Plant and crop databases / David E. Matthews, Gerard R. Lazo, and Olin D. Anderson -- Plant genome annotation methods / Shu Ouyang ... [et al.] -- Molecular plant breeding : methodology and achievements / Rajeev K. Varshney ... [et l.] -- Practical delivery of genes to the marketplace / David A. Fischhoff and Molly N. Cline -- Ecological genomics of natural plant populations : the Israeli perspective / Eviatar Nevo -- Genome sequencing approaches and successes / Michael Imelfort ... [et al.]
  • 1. Using reverse genetics to develop small knockout collections for specific biological questions / J. Northey and P. McCourt -- 2. Visualizing auxin transport routes in Arabidopsis leaf primordial / Danielle Marcos and Thomas Berleth -- 3. Gene expression analyses for elucidating mechanisms of hormonal action in plants / George W. Bassel and Nicholas J. Provart -- 4. Measurement of plant hormones by liquid chromatography-mass spectrometry / Stacey J. Owen and Suzanne R. Abrams -- 5. Measurement of abscisic acid and gibberellins by gas chromatography/mass spectrometry / Masanori Okamoto ... [et al.] -- 6. Pull-down assays for plant hormone research / Stefab Kepinski -- 7. Binding assays for brassinosteroid receptors / Ana Caño-Delgado and Zhi-Yong Wang -- 8. Binding assays for abscisic acid receptors / Fawzi A. Razem and Robert D. Hill -- 9. Cytokinin sensing systems using microorganisms / Masayuki Higuchi, Tatsuo Kakimoto and Takeshi Mizuno -- 10. Hormone-binding assay using living bacteria expressing eukaryotic receptors / Georgy A. Romanov and S.N. Lomin -- 11. Discovery of plant microRNAs and short-interfering RNAs by deep parallel sequencing / Padmanabhan Chellappan and Hailing Jin -- 12. The use of chemical genomics to investigate pathways intersecting auxin-dependent responses and endomembrane trafficking in Arabidopsis thaliana / Lorena Norambuena, Glenn R. Hicks and Natasha V. Raikhel.
  • Studying NB-LRR immune receptor localization by agroinfiltration transient expression / Patrick Cournoyer and S.P. Dinesh-Kumar -- Fragment complementation and co-immunoprecipitation assays for understanding R protein structure and function / Peter Moffett -- Purification of resistance protein complexes using a biotinylated affinity (HPB) tag / Yiping Qi and Fumiaki Katagiri -- Biochemical purification of native immune protein complexes / James M. Elmore and Gitta Coaker -- Chromatin immunoprecipitation to identify global targets of WRKY transcription factor family members involved in plant immunity / Mario Roccaro and Imre E. Somssich -- Dose-response to and systemic movement of dexamethasone in the GVG-inducible transgene system in Arabidopsis / Xueqing Geng and David Mackey -- Quantifying alternatively spliced mRNA via capillary electrophoresis / Xue-Cheng Zhang and Walter Gassmann -- Constructing haustorium-specific cDNA libraries from rust fungi / Ann-Maree Catanzariti [and others] -- Microaspiration of esophageal gland cells and cDNA library construction for identifying parasitism genes of plant-parasitic nematodes / Richard S. Hussey, Guozhong Huang, and Rex Allen -- Construction of Pseudomonas syringae pv. tomato DC3000 mutant and polymutant strains / Brian H. Kvitko and Alan Collmer -- A straightforwward protocol for electro-transformation of Phytophthora capsici zoospores / Edgar Huitema, Matthew Smoker, and Sophien Kamoun -- Propagation, storage, and assays with Hyaloperonospora arabidopsidis : a model oomycete pathogen of Arabidopsis / John M. McDowell [and others] -- Assaying effector function in planta using double-barreled particle bombardment / Shiv D. Kale and Brett M. Tyler -- Assays for effector-mediated suppression of programmed cell death in yeast / Yuanchao Wang and Qian Huang -- Purification in effector-target protein complexes via transient expression in Nicotiana benthamiana / Joe Win, Sophien Kamoun, and Alexandrea M.E. Jones -- Imaging fluorescently tagged Phytophthora effector proteins inside infected plant tissue / Petra C. Boevink, Paul R.J. Birch, and Stephen C. Whisson -- Immunolocalization of pathogen effectors / Eric Kemen, Kurt Mendgen, and Ralf T. Voegele -- Laser capture microdissection of nematode feeding cells / Nagabhushana Ithal and Melissa G. Mitchum -- Laser microdissection of plant-fungus interaction sites and isolation of RNA for downstream expression profiling / Divya Chandran, Noriko Inada, and Mary C. Wildermuth -- Global expression profiling of RNA from laser microdissected cells at fungal-plant interaction sites / Divya Chandran, Greg Hather, and Mary C. Wildermuth -- Visualizing cellular dynamics in plant-microbe interactions using fluorescent-tagged proteins / William Underwood, Serry Koh, and Shauna C. Somerville.
  • Plant lipid signaling protocols 2013
    Springer Protocols
    As scientist begin to understand the complexity of lipid signaling and its roles in plant biology, there is an increasing interest in their analysis. Due to the low abundancy and transient nature of some of these hydrophobic compounds, this is not always easy. In Plant Lipid Signaling Protocols, expert researchers in the field detail experimental approaches by which plant signaling lipids can be studied. These methods and techniques include analysis of plant signaling lipids, including detailed protocols to detect various relevant compounds by targeted or non-targeted approaches; to assay relevant enzyme activities in biological material or using recombinant enzymes; to test for specific binding of signaling lipids to protein partners; or to visualize signaling lipids or lipid-derived signals in living plant cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Lipid Signaling Protocols aids plant researchers in the continuing to study the roles of lipid signals.
  • Plant metabolomics 2006
  • Roles and functions of plant mineral nutrients / Frans J.M. Maathuis and Eugene Diatloff -- Plant growth and cultivation / Dorina Podar -- Protocols for growing plant symbioses: mycorrhiza / Michael Schultze -- Protocols for growing plant symbioses: rhizobia / Benjamin Gourion, Marie Bourcy, Viviane Cosson, and Pascal Ratet -- Plant cell suspension cultures / Roberto Moscatiello, Barbara Baldan, and Lorella Navazio -- Soil analysis using visible and near infrared spectroscopy / Johanna Wetterlind, Bo Stenberg, and Raphael A. Viscarra Rossel -- Mineral composition analysis: measuring anion uptake and anion concentrations in plant tissues / Malcolm J. Hawkesford, Saroj Parmar, and Peter Buchner -- Multielement plant tissue analysis using ICP spectrometry / T.H. Hansen, T.C. de Bang, K.H. Laursen, P. Pedas, S. Husted, and J.K. Schjoerring -- Mapping element distributions in plant tissues using synchrotron X-ray fluorescence techniques / Erica Donner, Martin D. de Jonge, Peter M. Kopittke, and Enzo Lombi -- Flux measurements of cations using radioactive tracers / D.T. Britto and H.J. Kronzucker -- Ion flux measurements using the MIFE technique / Sergey Shabala, Lana Shabala, Jayakumar Bose, Tracey Cuin, and Ian Newman -- Sampling and analysis of phloem sap / Sylvie Dinant and Julia Kehr -- Methods for xylem sap collection / M. Alexou and A.D. Peuke -- Plant single cell sampling / Wieland Fricke -- Measurements of cytosolic ion concentrations in live cells / Veena S. Anil, Kavitha P.G., Sam Kuruvilla, Pavan Kumar, and M.K. Mathew -- Real time measurement of cytoplasmic ions with ion-selective microelectrodes / Anthony J. Miller -- Large-scale plant ionomics / John M.C. Danku, Brett Labner, Elena Yakubova, and David E. Salt -- Applications of high-throughput plant phenotyping to study nutrient use efficiency / Bettina Berger, Bas de Regt, and Mark Tester.
  • The tomato leaf as a model system for organogenesis -- Usefulness of Physcomitrella patens for studying plant organogenesis -- The dicot root as a model system for studying organogenesis -- Genetic control of root organogenesis in cereals -- Gene expression analysis of aquatic angiosperms podostemaceae to gain insight into the evolution of their enigmatic morphology -- Brown algae as a model for plant organogenesis -- Microscopic analysis of ovule development in Arabidopsis thaliana -- Imaging of phenotypes, gene expression, and protein localization during embryonic root formation in Arabidopsis -- Inducible system for lateral roots in Arabidopsis thaliana and maize -- Adventitious root induction in Arabidopsis thaliana as a model for in vitro root organogenesis -- High-throughput, noninvasive imaging of root systems -- Small-molecule screens to study lateral root development -- Cell lineage analyses in living tissues -- Protein immunolocalization in maize tissues -- Auxin immunolocalization in plant tissues -- Gene expression analysis of shoot apical meristem cell types -- Kinematic analysis of cell division in leaves of mono- and dicotyledonous species: A basis for understanding growth and developing refined molecular sampling strategies -- Regeneration in arabidopsis tissue culture -- Isolation and analysis of mRNAs from specific cell types of plants by ribosome immunopurification -- Analyzing small and long RNAs in plant development using non-radioactive in situ hybridization -- Analyzing protein distribution in plant tissues using "Whole-mount" Immunolocalization -- Culture methods and mutant generation in the filamentous brown algae Ectocarpus siliculosus -- Building simulation models of developing plant organs using VirtualLeaf.
  • v. 1. The Background.
  • Plant proteomics 2007
  • Total protein extraction with TCA-acetone / Valérie Méchin, Catherine Damerval, and Michel Zivy -- Phenol extraction of proteins for proteomic studies of recalcitrant plant tissues / Mireille Faurobert, Esther Pelpoir, and Jamila Chaïb -- Protein extraction from cereal seeds / Gérard Branlard and Emmanuelle Blancel -- Protein extraction from xylem and phloem sap / Julia Kehr and Martijn Rep -- Protein extraction from woody plants / Christophe Plomion and Céline Lalanne -- Isolation of chloroplast proteins from Arabidopsis thaliana for proteome analysis / Klaas J. van Wijk, Jean-Benoit Peltier, and Lisa Giacomelli -- Isolation and subfractionation of plant mitochondria for proteomic analysis / Holger Eubel, Joshua L. Heazlewood, and A. Harvey Millar -- Extraction of nuclear proteins from root meristematic cells / Fernando González-Camacho and Francisco Javier Medina -- Isolation of nuclear proteins / Setsuko Komatsu -- Isolation of cell wall proteins from Medicago sativa stems / Bonnie S. Watson and Lloyd W. Sumner -- Plant plasma membrane protein extraction and solubilization for proteomic analysis / Véronique Santoni -- Detergents and chaotropes for protein solubilization before two-dimensional electrophoresis / Thierry Rabilloud ... [et al.] -- Two-dimensional electrophoresis for plant proteomics / Walter Weiss and Angelika Görg -- Visible and fluorescent staining of two-dimensional gels / François Chevalier, Valérie Rofidal, and Michel Rossignol -- Two-dimensional differential in-gel electrophoresis (DIGE) of leaf and roots of Lycopersicon esculentum / Matthew Keeler ... [et al.] -- Quantitative analysis of 2D gels / Michel Zivy -- Multivariate data analysis of proteome data / Kåre Engkilde, Susanne Jacobsen, and Ib Søndergaard -- Edman sequencing of plant proteins from 2D gels / Setsuko Komatsu -- Peptide mass fingerprinting: identification of proteins by MALDI-TOF / Nicolas Sommerer, Delphine Centeno, and Michel Rossignol -- Protein identification using nano liquid chromatography-tandem mass spectrometry / Luc Negroni -- Two-dimensional nanoflow liquid chromatography-tandem mass spectrometry of proteins extracted from rice leaves and roots / Linda Breci and Paul A. Haynes -- Separation, identification, and profiling of membrane proteins by GFC/IEC/SDS-PAGE and MALDI TOF MS / Wojciech Szponarski ... [et al.] -- The PROTICdb database for 2-DE proteomics / Olivier Langella, Michel Zivy, and Johann Joets -- Identification of phosphorylated proteins / Maria V. Turkina and Alexander V. Vener -- Plant proteomics and glycosylation / Anne-Catherine Fitchette ... [et al.] -- Blue-native gel electrophoresis for the characterization of protein complexes in plants / Jesco Heinemeyer, Dagmar Lewejohann, and Hans-Peter Braun -- Electroelution of intact proteins from SDS-PAGE gels and their subsequent MALDI-TOF MS analysis / Zhentian Lei ... [et al.] -- Generation of plant protein microarrays and investigation of antigen-antibody interactions / Birgit Kersten and Tanja Feilner -- Phosphorylation studies using plant protein microarrays / Tanja Feilner and Birgit Kersten.
  • Analysis of High-Throughput Sequencing Data / Shrinivasrao P. Mane, Thero Modise, Bruno W. Sobral -- Identification of Plant microRNAs Using Expressed Sequence Tag Analysis / Taylor P. Frazier, Baohong Zhang -- Microarray Data Analysis / Saroj K. Mohapatra, Arjun Krishnan -- Setting Up Reverse Transcription Quantitative-PCR Experiments / Madana M. Ambavaram, Andy Pereira -- Virus-Induced Gene Silencing in Nicotiana benthamiana and Other Plant Species / Andrew Hayward, Meenu Padmanabhan, S. P. Dinesh-Kumar -- Agroinoculation and Agroinfiltration: Simple Tools for Complex Gene Function Analyses / Zarir Vaghchhipawala, Clemencia M. Rojas, Muthappa Senthil-Kumar, Kirankumar S. Mysore -- Full-Length cDNA Overexpressor Gene Hunting System (FOX Hunting System) / Mieko Higuchi, Youichi Kondou, Takanari Ichikawa, Minami Matsui -- Activation Tagging with En/Spm-I /dSpm Transposons in Arabidopsis / Nayelli Marsch-Martínez, Andy Pereira -- Activation Tagging and Insertional Mutagenesis in Barley / Michael A. Ayliffe, Anthony J. Pryor -- Methods for Rice Phenomics Studies / Chyr-Guan Chern, Ming-Jen Fan, Sheng-Chung Huang, Su-May Yu, Fu-Jin Wei, Cheng-Chieh Wu, Arunee Trisiriroj, Ming-Hsing Lai, Shu Chen, Yue-Ie C. Hsing -- Development of an Efficient Inverse PCR Method for Isolating Gene Tags from T-DNA Insertional Mutants in Rice / Sung-Ryul Kim, Jong-Seong Jeon, Gynheung An -- Transposon Insertional Mutagenesis in Rice / Narayana M. Upadhyaya, Qian-Hao Zhu, Ramesh S. Bhat -- Reverse Genetics in Medicago truncatula Using Tnt1 Insertion Mutants / Xiaofei Cheng, Jiangqi Wen, Million Tadege, Pascal Ratet, Kirankumar S. Mysore -- Screening Arabidopsis Genotypes for Drought Stress Resistance / Amal Harb, Andy Pereira -- Protein Tagging for Chromatin Immunoprecipitation from Arabidopsis / Stefan Folter -- Yeast One-Hybrid Screens for Detection of Transcription Factor DNA Interactions / Pieter B. Ouwerkerk, Annemarie H. Meijer -- Plant Metabolomics by GC-MS and Differential Analysis / Joel L. Shuman, Diego F. Cortes, Jenny M. Armenta, Revonda M. Pokrzywa, Pedro Mendes, Vladimir Shulaev -- Gramene Database: A Hub for Comparative Plant Genomics / Pankaj Jaiswal.
  • Plant secondary metabolites 2007
    Springer Protocols
  • Multiple dimensions in plant signal transduction : an overview / Jorge J. Casal -- Phenotyping of Arabidopsis mutants for developmental effects of gene deletions / Cordelia Bolle -- Phenotyping of abiotic responses and hormone treatment in Arabidopsis / Cordelia Bolle -- Accurate real-time reverse transcription quantitative PCR / Marco Klatte and Petra Bauer -- Probing spatio-temporal intracellular calcium variations in plants / Axel Mithöfer, Christian Mazars, and Massimo E. Maffei -- Dynamic redox measurements with redox-sensitive GFP in plants by confocal laser scanning microscopy / Andreas J. Meyer and Thorsten Brach -- Imaging reactive oxygen species in vivo / Steven M. Driever ... [et al.] -- Identification of thioredoxin targeted proteins using thioredoxin single cysteine mutant-immobilized resin / Ken Motohashi, Patrick G.N. Romano, and Toru Hisabori -- Determination of in vivo protein phosphorylation in photosynthetic membranes / Julia P. Vainonen, Alexander V. Vener, and Eva-Mari Aro -- Examining protein stability and its relevance for plant growth and development / Claus Schwechheimer ... [et al.] -- Probing circadian rhythms in Chlamydomonas rheinhardtii by functional proteomics / Volker Wagner and Maria Mittag -- Bimolecular fluorescence complementation (BiFC) to study protein-protein interactions in living plant cells / Katia Schütze, Klaus Harter, and Christina Chaban -- Fluorescence cross-correlation spectroscopy of plant proteins / Hideki Muto, Masataka Kinjo, and Kotaro T. Yamamoto -- The determination of protein-protein interactions by the mating-based split-ubiquitin-system (mbSUS) / Christopher Grefen, Petr Obrdlik, and Klaus Harter -- Functional complementation of yeast mutants to study plant signalling pathways / Norbert Mehlmer, Elisabeth Scheikl-Pourkhalil, and Markus Teige -- Phosphatase activities analyzed by in vivo expressions / Alois Schweighofer, Zahra Ayatollahi, and Irute Meskiene -- Chromatin immunoprecipitation experiments to investigate in vivo binding of Arabidopsis transcription factors to target sequences / Benjamin Fode and Christiane Gatz -- Fluorescence-based electrophoretic mobility shift assay in the analysis of DNA-binding proteins / Sebastian Steiner and Thomas Pfannschmidt -- Analysis of plant regulatory DNA sequences by the yeast-one-hybrid assay / Dierk Wanke and Klaus Harter -- Analysis of plant regulatory DNA sequences by transient protoplast assays and computer aided sequence evaluation / Kenneth W. Berendzen, Klaus Harter, and Dierk Wanke -- RNA protein interaction mediating post-transcriptional regulation in the circadian system / Jan C. Schöning and Dorothee Staiger.
  • Transposable elements are DNA sequences with the capacity to move within a genome. Although their presence and impact has long been known, the recent genome-wide analysis of many eukaryotic genomes has uncovered their major role in genome dynamics and function. The present book explains how to recognize and study transposable elements, e.g. by using state-of-the-art strategies based on new-generation sequencing. Moreover, the impact of transposable elements on plant genome structure and function is reviewed in detail and illustrated in examples and case studies. The book is intended both for readers familiar with the field and for newcomers. With large-scale sequencing becoming increasingly available, more and more people will come across transposable element sequences in their data, and this volume will hopefully help to convince them that transposable elements are not just "junk" DNA, and may actually be the most interesting and fun part of their data!
  • Plant viral vectors 2014
    In this volume, the authors provide an excellent overview of how far the plant viral vector field has come. The discipline is no longer exclusively in the domain of academics-there is a small, but growing number of small biotechnology companies that exploit plant viruses as the platform for commercial innovation in crop improvement, industrial product manufacturing, and human and veterinary health care.
  • Plant-derived vaccines : technologies & applications / Franco M. Buonaguro -- Patents and molecular farming / Pascal M.W. Drake & Harry Thangaraj -- In planta production of recombinant and indigenous adjuvants / Antonio Granell, Asun Fernandez-del-Carmen & Diego Orzáez -- Rapid and high-yield production of immunotherapeutic plant-made antibodies / Cristina Capodicasa, Marcello Donini, Maria Elena Villani & Eugenio Benvenuto -- Vaccine peptide display on recombinant tobacco mosaic virus particles / Tatiana V. Komarova, Igor V. Petrunia & Yuri L. Dorokhov -- Plastid transformation as a tool for plant-based production of vaccines and therapeutic proteins / Paolo Lenzi, Nunzia Scotti, Pal Maliga & Teodoro Cardi -- Prophylactic and therapeutic HPV vaccines from plants / Edward P. Rybicki, Colomba Giorgi & Rosella Franconi -- Plant-derived anti-HIV-1 proteins / Nunzia Scotti, Luigi Buonaguro, Maria Lina Tornesello, Teodoro Cardi & Franco Maria Buonaguro -- Plant-based hepatitis B vaccines / Sergei N. Shchelkunov & Galina A. Shchelkunova -- Influenza vaccines : new perspectives from plants / Chiara Lico, Giampaolo Buriani, Floriana Capuano, Eugenio Benvenuto & Selene Baschieri -- Plant-made mucosal vaccines / Rurick K. Salyaev, Maria Manuela Rigano & Natalya I. Rekoslavskaya -- Current status of plant-made veterinary vaccines / Assunta Pelosi, Claire Penney, Huai-Yian Ling & Amanda M. Walmsley.
  • The use of protoplasts to study innate immune responses / Ping He, Libo Shan, and Jen Sheen -- Marker-exchange mutagenesis and complementation strategies for the gram-negative bacteria Xanthomonas oryzae pv. oryzae / Sang-Won Lee and Pamela C. Ronald -- Whole-genome analysis to identify type III-secreted effectors / Boris A. Vinatzer and Jean T. Greenberg -- In planta expression of oomycete and fungal genes / Thirumala-Devi Kanneganti, Edgar Huitema, and Sophien Kamoun -- Use of nipponbare bac clones for physical mapping of an R gene locus in rice / Jong-Seong Jeon and Pamela C. Ronald -- Agrobacterium-mediated transformation to create an insertion library in magnaporthe grisea / Sara L.Tucker and Marc J. Orbach -- Identification of components in disease-resistance signaling in arabidopsis by map-based cloning / Yuelin Zhang, Jane Glazebrook, and Xin Li -- Yeast two-hybrid approaches to dissecting the plant defense response / Mawsheng Chern, Todd Richter, and Pamela C. Ronald -- Use of rolling-circle amplification for large-scale yeast two-hybrid analyses / Xiaodong Ding, Yan Zhang, and Wen-Yuan Song -- Preparative denaturing isoelectric focusing for enhancing sensitivity of proteomic studies / Antonio Serna-Sanz, Greg Rairdan, and Scott C. Peck -- Use of massively parallel signature sequencing to study genes expressed during the plant defense response / Blake C. Meyers, Christian D. Haudenschild, and Kalyan Vemaraju -- Use of microarray analysis to dissect the plant defense response / Jane Glazebrook -- Use of robust long-serial analysis of gene expression to identify novel fungal and plant genes involved in host-pathogen interactions / Malali Gowda ... [et al.] -- Analysis of gene function in rice through virus-induced gene silencing / Xin Shun Ding, C. Srinivasa Rao, and Richard S. Nelson -- Use of RNA interference to dissect defense-signaling pathways in rice / Chuansheng Mei, Xiangjun Zhou, and Yinong Yang -- Virus-induced gene silencing in plant roots / Isgouhi Kaloshian -- Methods for engineering resistance to plant viruses / Mysore R. Sudarshana, Gourgopal Roy, and Bryce W. Falk -- Development of genetically engineered resistant papaya for papaya ringspot virus in a timely manner: a comprehensive and successful approach / Savarni Tripathi, Jon Suzuki, and Dennis. Gonsalves.
  • Plant vaccines: an immunological perspective / D.C. Hooper -- Display of peptides on the surface of tobacco mosaic virus particles / M.L. Smith ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality / S. Chebolu and H. Daniell -- Production of antibodies in plants: approaches and perspectives / K. Ko, R. Brodzik and Z. Steplewski -- Plant production of veterinary vaccines and therapeutics / R.W. Hammond and L.G. Nemchinov -- Plant-based oral vaccines: results of human trials / C.O. Tacket.
  • Print Material
  • With novel approaches to the application of new technologies via research based studies on stem cells, tissue engineering and new fields of reconstructive transplant (face, hand or larynx transplants), this book facilitates access to this latest knowledge which is not traditionally part of the plastic surgery curriculum. Plastic and Reconstructive Surgery ? Experimental Models and Research Designs presents pertinent introductions to different fields (stem cell, transplantation, nerve regeneration, tissue engineering) and experimental models which can be used as a tool to develop technologies of interest by various groups of surgeons. Plastic and Reconstructive Surgery ? Experimental Models and Research Designs benefits a range of surgeons, including plastic and reconstructive surgeons, microsurgeons, hand surgeons, orthopedic surgeons, neurosurgeons and transplant surgeons.
  • "Plastic Surgery Review meets the need for a high-yield, compact review book for the plastic surgery in-service, written board, and maintenance of certification examinations. Its 50 chapters are organized into four sections tested by the plastic surgery in-service examination: comprehensive plastic surgery craniomaxillofacial surgery breast and cosmetic surgery hand and lower extremity. An outline format with bullet points, tables, figures, mnemonics, and references facilitates review and memorization. Invited expert reviewers ensure the material is accurate and up-to-date"--Provided by publisher.
  • Plastic Surgery Secrets-the first Secrets Seriesʼ title in the PLUS format-offers an easy-to-read, information-at-your-fingertips approach to plastic and reconstructive surgery and hand surgery. Jeffrey Weinzweig has joined forces with world-renowned plastic surgeons Joseph McCarthy, Julia Terzis, Joseph Upton, Fernando Ortiz-Monasterio, and Luis Vasconez, and others to bring you the expert perspective you need to grasp the nuances of this specialty. This new edition features an additional color that highlights tables, legends, key terms, section and chapter titles, and web references. All this, along with the popular question-and answer approach and list of the "Top 100 Plastic Surgery Secrets," make it a perfect concise board review tool and a handy clinical reference. Maintains the popular and trusted Secrets Seriesʼ format, using questions and short answers for effective and enjoyable learning. Provides the most current overview and authoritative coverage of all topics thanks to contributions from an impressive list of over 300 experts in the field of plastic surgery and multiple related specialties.
  • Vol. 1: Section 1: Principles -- Section 2: Techniques -- Section 3: Basic Principles of Craniomaxillofacial Surgery -- Section 4: Craniofacial Surgery -- Section 5: Maxillofacial Surgery -- Section 6: Pediatric Plastic Surgery -- Section 7: Head and Neck Surgery -- Vol. 2: Section 8: Hand Surgery -- Section 9: Aesthetic Surgery.
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    v. 1. General principles -- v. 2. The head and neck, part 1 -- v. 3. The head and neck, part 2 -- v. 4. Pediatric plastic surgery -- v. 5. Tumors of the head, neck, and skin -- v. 6. Trunk and lower extremity -- v. 7. The hand and upper limb, part 1 -- v. 8. The hand and upper limb, part 2.
  • Plastic surgery. 3rd ed. v.1-6, 2013
    Fully updated to meet the demands of the 21st-century surgeon, this title provides you with all the most current knowledge and techniques across your entire field, allowing you to offer every patient the best possible outcome. Edited by Drs. Mathes and Hentz in its last edition, this six-volume plastic surgery reference now features new expert leadership, a new organization, new online features, and a vast collection of new information - delivering all the state-of-the-art know-how you need to overcome any challenge you may face. Renowned authorities provide evidence-based guidance to help you make the best clinical decisions, get the best results from each procedure, avoid complications, and exceed your patients' expectations.
  • Ch. 1 Introduction: Plasticity in the visual system: from genes to circuits -- Pt. I Retinal and thalamic plasticity -- Ch. 2 Synaptic plasticity and structural remodeling of rod and cone cells -- Ch. 3 Retinal remodeling: circuitry revisions triggered by photoreceptor degeneration -- Ch. 4 Retinal plasticity and interactive cellular remodeling in retinal detachment and reattachment -- Ch. 5 Experience-dependent rewiring of retinal circuitry: involvement of immediate early genes -- Ch. 6 Attentional activation of cortico-reticulo-thalamic pathways revealed by Fos imaging -- Pt. II Cortical plasticity -- Ch. 7 Neuromodulatory transmitters in sensory processing and plasticity in the primary visual cortex -- Ch. 8 Critical calcium-regulated biochemical and gene expression programs involved in experience-dependent plasticity -- Ch. 9 The molecular biology of sensory map plasticity in adult mammals -- Ch. 10 Plasticity of retinotopic maps in visual cortex of cats and monkeys after lesions of the retina or primary visual cortex -- Ch. 11 Intra-cortical inhibition in the regulation of receptive field properties and neural plasticity in the primary visual cortex -- Ch. 12 Plasticity in V1 induced by perceptual learning -- Ch. 13 Investigating higher order cognitive functions in the dorsal (magnocellular) stream of visual processing -- Ch. 14 Dopamine-dependent associative learning of workload-predicting cues in the temporal lobe of the monkey -- Pt. III Theoretical considerations -- Ch. 15 Linking visual development and learning to information processing: pre-attentive and attentive brain dynamics -- Ch. 16 Conclusion: a unified theoretical framework for plasticity in visual circuitry.
  • The polycarbonate products, adhesives, and composite resins used in dentistry may have the potential to release bisphenol-A (BPA). BPA is known to exert effects at very low doses and presents a risk to reproductive, neurological, behavioural, and metabolic development, however, the actual effects induced by dental materials have not been sufficiently covered and critically analyzed. Nevertheless, many practicing dentists will be confused by the occasionally contradictory and often misinterpreted evidence in the literature. This book therefore represents a timely and comprehensive review of our current knowledge of BPA release from dental polymers and the potential presence of endocrinological consequences. After a review of the history and evolution of the issue within the broader biomedical context, the estrogenicity of BPA is explained. The basic chemistry of the polymers used in dentistry is then presented in a simplified and clinically relevant manner. Key chapters in the book carefully evaluate the release of BPA from dental polymets and the estrogenicity of these materials. Currently available evidence on the potential estrogenic action of dental composites, sealants, and adhesives is presented, and the exaggerated conclusions of various methodological protocols are assessed. The entire dental community will find this book to be an invaluable aid to safe practice.
  • Platelet physiology / Martin Quinn -- Platelet integrins and signaling / Karlheinz Peter -- Platelet adhesion / Brian Savage and Zaverio M. Ruggeri -- Structure-function of the platelet cytoskeleton / Elaine L. Bearer -- Platelets and inflammation / Meinrad Gawaz -- Platelet signal-dependent protein synthesis / Stephan Lindemann ... [et al.] -- Phosphoproteomics of human platelets / Katrin Marcus and Helmut E. Meyer -- Platelet function studies / Dermot Cox -- Platelet function under flow / José A. López, Ian del Conde, and Jing-Fei Dong -- Pharmacodynamics of GPIIb-IIIa receptor blockade / Lisa K. Jennings and Melanie M. White -- Prostanoid generation in platelet function: assessment and clinical relevance / Bianca Rocca and Carlo Patrono -- Platelets and prothrombin / Michael Kalafatis ... [et al.] -- Markers of platelet activation and granule secretion / Alan D. Michelson and Mark I. Furman -- Genomic and proteomic analysis of platelets: clinical applications / Andrew Maree and James McRedmond -- Antiplatelet agents / Jacqueline Saw and David J. Moliterno -- Assessing platelet function in clinical trials / Neil Kleiman.
  • Platelets and megakaryocytes v.1-3, 2004, 2011
    Springer Protocols
    v. 2 Springer Protocols
    v.3 Springer Protocols
    v. 1. Functional assays -- v. 2. Perspectives and techniques.
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  • Ch.1. Theoretical Foundations -- Ch.2. Recognizing, Addressing, and Celebrating Diversity -- Ch.3. Logistics -- Ch.4. Data Collection: Intake and Mental Status -- Ch.5. Assessment -- Ch.6. Case Conceptualization -- Ch.7. Treatment Planning -- Ch.8. Interventions -- Ch.9. Session Activities -- Ch.10. Jennifer.
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  • Anatomy of the pleura -- Physiology of the pleural space-- Physiological effects of pneumothorax and pleural effusion-- Animal models in pleural investigation-- Cytokines and the pleura-- Radiographic examinations-- Clinical manifestations and useful tests-- Approach to the patient-- Transudative pleural effusions-- Pleural effusions related to metastatic malignancies-- Primary tumors of the pleura -- Parapneumonic effusions and empyema-- Tuberculous pleural effusions-- Pleural effusion secondary to fungal infections, actinomycosis, and nocardiosis -- Pleural effusion due to parasitic infection-- Pleural effusion due to acquired immunodeficiency syndrome, other viruses, mycoplasma pneumoniae, and rickettsiae-- Pleural effusion due to pulmonary embolization -- Pleural effusion secondary to diseases of the gastrointestinal tract -- Pleural effusion secondary to diseases of the heart-- Pleural disease in obstetrics and gynecology -- Pleural disease due to collagen vascular diseases -- Pleural effusion due to drug reactions -- Pleural effusion due to miscellaneous diseases-- Pneumothorax-- Hemothorax-- Chylothorax and pseudochylothorax -- Other pleural diseases -- Thoracentesis (diagnostic and therapeutic) and pleural biopsy -- Chest tubes -- Thoracoscopy.
  • Print Material
    Pathophysiology of signs and symptoms of coma -- Examination of the comatose patient -- Structural causes of stupor and coma -- Specific causes of structural coma -- Multifocal, diffuse, and metabolic brain diseases causing delirium, stupor, or coma -- Psychogenic unresponsiveness -- Approach to management of the unconscious patient -- Brain death -- Prognosis in coma and related disorders of consciousness, mechanisms underlying outcomes, and ethical considerations.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available. 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