BookLewis, Kim.
Summary: This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.
Contents:
Intro; Introduction; Contents; Contributors;
Chapter 1: Evolution Under Antibiotic Treatments: Interplay Between Antibiotic Persistence, Tolerance, and Resistance; 1.1 Distinguishing Between Resistance, Tolerance, and Antibiotic Persistence; 1.1.1 Antibiotic Resistance; 1.1.2 Antibiotic Tolerance; 1.1.3 Antibiotic Persistence; 1.1.4 Different Types of Persistent Bacteria; 1.1.4.1 Triggered Persistence [Previously Called Type I (Balaban et al. 2004)]; 1.1.4.2 Spontaneous Persistence [Previously Called Type II (Balaban et al. 2004)]; 1.2 Quantification of Antibiotic Tolerance and Persistence 1.3 Evolution of Antibiotic Tolerance Under Intermittent Antibiotic Treatments1.3.1 Tolerance and Persistence-by-Lag Evolve to Match the Duration of the Antibiotic Treatment; 1.3.2 Evolution of Stationary Phase Triggered Antibiotic Persistence; 1.3.3 Evolution of Drug-Induced Tolerance; 1.3.4 Antibiotic Tolerance in the Clinic; 1.3.4.1 Evolution of Tolerance in the Clinic; 1.3.4.2 Techniques to Detect Tolerance in the Clinic; 1.4 Antibiotic Tolerance and Persistence Promote the Evolution of Resistance; 1.5 Conclusion; References 2.3.2.1 The Mesenteric Lymph Nodes and Spleen Are Preferred Niches for Antibiotic-Tolerant S. Typhimurium During Infection2.3.2.2 The Subpopulation of S. Typhimurium Capable of Surviving Antibiotic Treatment During Infection Are Slow or Non-Growing ... ; 2.4 Molecular Mechanisms: How to Cope with Combined Host and Antibiotic Challenges?; 2.4.1 Formation of Salmonella Antibiotic Persisters During Infection; 2.4.2 Salmonella Antibiotic Persisters Must Survive the Immune Response During Infection; 2.5 Going Forward: Future Directions and Challenges; References
Chapter 2: Antibiotic Persisters and Relapsing Salmonella enterica Infections2.1 Persistence of Infection, Antibiotic Persistence, and Antibiotic Persistence During Infection: What Is the Difference?; 2.2 A Brief Introduction to Salmonella enterica Infections; 2.3 Evidence for Role of Antibiotic Persistent Salmonella in Relapsing Infections; 2.3.1 Clinical Evidence for Antibiotic Persistence During Infection in Humans; 2.3.2 Experimental Evidence for Antibiotic Persistence During Infection in Mice
Chapter 3: The Biology of Persister Cells in Escherichia coli3.1 Basic Concepts of Persister Cell Biology; 3.1.1 Persister Formation as a Phenotypic Switch into Dormancy; 3.1.2 Stochasticity and Heterogeneity of Persister Formation; 3.1.3 Biological Functions of Persister Cells; 3.2 Unraveling the Genetic Basis of Persister Formation; 3.2.1 Conceptual Overview; 3.2.2 Distinguishing Persister Formation/Survival from Phenotypic Resistance; 3.3 Non-Specific Mechanisms of Persister Cell Formation; 3.3.1 Energy Metabolism and Oxygen; 3.3.2 PASH: ``Persistence as Stuff Happenś́