BookSherif El-Khamisy, editor.
Summary: "The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combatdegenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine"--Publisher's description.
Contents:
Approaches for identifying novel targets in precision medicine: lessons from DNA repair / Dean T. Williams, Christopher J. Staples
Nucleotide excision repair: from neurodegeneration to cancer / Anastasios Liakos, Matthieu D. Lavigne, Maria Fousteri
Role of protein linked DNA breaks in cancer / Walaa R. Allam, Mohamed E. Ashour, Amr A. Waly, Sherif El-Khamisy
The emerging role of proteomics in precision medicine: applications in neurodegenerative diseases and neurotrauma / Rana Alaaeddine, Mira Fayad, Eliana Nehme, Hisham F. Bahmad, Firas Kobeissy
The role of nitric oxide from neurological disease to cancer / Ahmed Maher, Mohamed F. Abdel Rahman, Mohamed Z. Gad
RNA nuclear export: from neurological disorders to cancer / Guillaume M. Hautbergue
Can astrocytes be a target for precision medicine? / Chloe F. Allen, Pamela J. Shaw, Laura Ferraiuolo
Mitochondrial diseases as model of neurodegeneration / Laila A. Selim, Heba Hassaan
Personalised medicine: genome maintenance lessons learned from studies in yeast as a model organism / Arwa A. Abugable, Dahlia A. Awwad, Dalia Fleifel, Mohamed M. Ali, Sherif El-Khamisy [and others]
The power of zebrafish in personalised medicine / Sarah Baxendale, Freek van Eeden, Robert Wilkinson
Personalized medicine and resurrected hopes for the management of Alzheimer's disease: a modular approach based on GSK-3[beta] inhibitors / Reem K. Arafa, Nehal H. Elghazawy
Regenerative medicine: advances from developmental to degenerative diseases / Nicholas F. Blair, Thomas J. R. Frith, Ivana Barbaric
Gene therapy in the nervous system: failures and successes / Jayanth S. Chandran, Joseph M. Scarrott, Pamela J. Shaw, Mimoun Azzouz.