Bookedited by Owen A. O'Connor, Won Seog Kim, Pier Luigi Zinzani.
Summary: "The immune system can be classified into 2 basic component: (1) the innate immune system, and (2) the acquired immune system. The innate immune system is considered to be relatively agnostic to any specific antigen, and is often described as invariant. The innate immune response is the first line of defense, and typically exhibits limited specificity. Examples of innate immune response may include phagocytosis by macrophases, barriers to infect provided by the skin and tears, NK- and mast cells, and complement mediated cytolysis. In contrast, the adaptive (or sometimes called acquired) immune response develops in response to specific antigen, being 'custom' designed for the antigen in question, usually occurs later in the immune response, and has the ability to recall the response to past infections. Components of a functioning acquired immune response might involve antigen presenting cells presenting antigen ot T-cells, the activation of specific T-cells which would signal to B-cells enlisting their engagement in the response and the production of highly specific antibody capable of binding specific antigen. T- and B- lymphocytes are the major types of lymphocytes found in the human body, where they can constitute 20-40% of all white blood cells, with only about 2-3% of these being found in the peripheral circulation, the remainder being localized to various lymphoid organ is (lymph nodes, spleen, submucosal tissue). Remarkably, the total mass of lymphocytes in the body can approximate the mass of the brain and liver"-- Provided by publisher.
Contents:
Fundamentals T-Cell Lymphocyte Biology / Claudio Tripodo, Stefano Pilleri
Mechanisms of T-Cell Lymphomagenesis / François Lemonnier, Philippe Gaulard, Laurence de Leval
Epigenetics of T-Cell Lymphoma / H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen O'Connor, Sean Harrop
Animal Models of T-Cell Lymphoma / Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe, Mamiko Sakata-Yanagimoto
The Geographic Distribution of the PTCL : Global Epidemiology / Amulya Yellala, Avyakta Kallam, James Armitage
Classification of the Peripheral T-Cell Lymphomas / Neval Ozkaya, Elaine Jaffee
Molecular Classification of the PTCLs / Tyler A. Herek, Javed Iqbal
Peripheral T-Cell Lymphoma
Not Otherwise Specified / Nora Bennani, Stephen Ansell
Angioimmunoblastic T-Cell Lymphoma (AITL) / Jehan Dupuis, Franck Morschhauser
The Spectrum of Anaplastic Large Cell Lymphoma / Jianping Kong, Andrew Feldman
HTLV-1-Positive Adult T-Cell Leukemia-Lymphoma (ATL) / Wataru Munakata, Kensei Tobinai
Natural Killer/T Cell Lymphomas / S.J. Kim, R. Suzuki, A. Jaccard, S.T. Lim, Won Seog Kim
T-Prolymphocytic Leukemia (T-PLL) / Dima El-Sharkawi, Claire Deardon
Large Granular Lymphocytes Leukemia (LGL) / Karolina H. Dziewulska, Katharine B. Moosic, HeeJin Cheon, Kristine C. Olson, David J. Feith, Thomas P. Loughran, Jr. Gamma Delta T-Cell Lymphomas / Francine Foss, Aadil Ahmed, Mina Xu
Enteropathy Associated T-Cell Lymphoma and Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma / Craig R. Soderquist, Jennifer Shingleton, Sandeep Dave, Govind Bhagat
Hepatosplenic T-Cell Lymphomas / Robert N. Stuver, Mwanasha Merrill, Salvia Jain
Cutaneous T-Cell Lymphoma / Alejandro Ariel Gru, Bethanie Rooke, Kevin Molloy, Julia Scarsbrick
Other Rare Subtypes of PTCL / Pier Paolo Picaluga
Standard Front-line Therapies / Raphael Koch, Lorenz Truemper
Approved Agents in the Relapsed or Refractory Setting, Excluding Brentuximab Vedotin / Helen Ma, Owen A. O'Connor
The Role for Autologous Stem Cell Transplantation (ASCT) in Peripheral T Cell Lymphomas (PTCL) / Juan Alejandro Ospina, H. Martinez-Cordero, J. Enciso, H. Idrobo
Allogeneic Stem Cell Transplantion / Anna Dodero, Paolo Corradini
Emerging Immunotherapy Approaches in Peripheral T-Cell Lymphomas / Barbara Pro, Andrei Shustov
Emerging New Small Molecules in Peripheral T-Cell Lymphomas / Alessandro Broccoli, Pier Luigi Zinzani
The Value and Relevance of T-Cell Lymphoma Registries / Tetiana Skrypets, Martina Manni, Monica Civallero, Iryna Kriachok, Massimo Federico
Innovative Chemotherapy-Free Approaches for the Treatment of PTCL / Enrica Marchi, Ahmed Sawas, Helen Ma, Luigi Scotto, Francesca Montanari
Global Collaborations / Dejan Radjeski, Eliza Hawke, Owen A. O'Connor, Pier Luigi Zinzani, WonSeog Kim, Enrica Marchi.