Bookeditors: Manish Kumar, Ashita Sharma, Praveen Kumar.
Summary: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.
Contents:
Intro
Preface
Contents
Editors and Contributors
List of Contributors
1: Phytochemicals in Cancer Chemoprevention: A Brief Perspective
1.1 Introduction
1.2 Phytochemicals in Cancer Therapy
1.3 Potential of Phytochemicals for Cancer Chemoprevention
1.3.1 Phytochemicals as ROS Scavengers and Redox Modulators
1.3.2 Phytochemicals in DNA Damage and Repair
1.3.3 Phytochemicals Control Gene Expression
1.3.4 Phytochemicals Modulate Phase 1 and Phase 2 Enzymes
1.3.5 Phytochemicals Inhibit Cell Proliferation
1.3.6 Phytochemicals Promote Autophagy 1.3.7 Phytochemicals Exhibit Anti-inflammatory Effects
1.3.8 Phytochemicals Modulate Tumor Metabolism
1.3.9 Phytochemicals Modulate Gut Microbiota to Prevent Cancer
1.4 Limitations of Phytochemicals as Therapeutics for Chemoprevention
1.4.1 Complex Mixture of Metabolites
1.4.2 Bioavailability of Phytochemicals
1.4.3 Biphasic Effects
1.5 Phytochemicals in Clinical Trials and the Therapies
1.6 Future Directions: Filling in the Gaps
1.7 Conclusions
References
2: Role of Phytochemicals in Modulating Signaling Cascades in Cancer Cells 2.4.5.1 Plant Products in the Modulation of PI3K-AKT Signaling
2.4.6 Wnt Cell Signaling
2.4.6.1 Plant Products in the Modulation of Wnt Signaling
2.4.7 mTOR Pathway
2.4.7.1 Plant Products in the Modulation of mTOR Signaling
2.4.8 Phytochemicals as Modulators of Antioxidant and Anti-Inflammatory Stress
2.4.9 Cell Cycle Modulators
2.4.10 Tumor Suppressor Genes Activation and DNA Repair Mechanism
2.4.11 Inducing Programmed Cell Death/Apoptosis
2.4.11.1 Induction of Apoptosis by Phytochemicals
2.5 Conclusion
References 3: Diverse Cancer Therapeutic Interactions: Complexities in Cancer Management
3.1 Introduction
3.2 Complex Interaction of Anticancer Drugs with Signal Transduction Pathways in Cells
3.3 Therapeutic Limitations of Anticancer Drugs
3.3.1 Doxorubicin
3.3.2 Abiraterone
3.3.3 Asparaginase (Erwinia chrysanthemi)
3.3.4 Axitinib
3.3.5 Tamoxifen
3.3.6 Crizotinib
3.4 Competing the Complex Cellular Networks Towards a Rational Cancer Therapy
3.5 Therapeutic Limitations Due to Personalized Cancer Treatment
3.5.1 Applications of Personalized Therapy