Bookeditor-in-chief Hamid M. Said ; associate editors Fayez K. Ghishan, Jonathan D. Kaunitz, Juanita L. Merchant, Jackie D. Wood.
Summary: "Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal function Presents new information on the brain-gut axis and microbiome Edited by preeminent scientists in the field Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more"--Publisher's description.
Contents:
Volume 1. Section I: Basic cell physiology, genetics, and growth of the GI tract
Transcription and epigenetic regulation
Gastrointestinal hormones
Growth factors in the intestinal tract
Hedgehog signaling in gastrointestinal morphogenesis and morphostasis
The role of hippo signaling in intestinal homeostasis
Notch pathway regulation of intestinal cell fate
WNT signaling in the intestine: development, homeostasis, disease
The cell cycle
Cell death
Molecular physiology of gastrointestinal function during development
Section II: Neurogastroenterology. Development of the enteric nervous system
Enteric neurogenesis
The physiology and pathophysiology of interstitial cells of Cajal: pacemaking, innervation, and stretch sensation
Enteric nervous system structure and neurochemistry related to function and neuropathology
Enteric nervous system: brain-in-the-gut
Brain processing of gastrointestinal sensory signaling
Extrinsic sensory afferent nerves innervating the gastrointestinal tract in health and disease
Neuroimaging of brain-gut interactions in functional gastrointestinal disorders
Enteric neural regulation of mucosal secretion
Neuromuscular function in the biliary tract
Physiology of gastric motility patterns
Clinical and translational aspects of normal and abnormal motility in the esophagus, small intestine and colon
Neurophysiologic mechanisms of human large intestinal motility
Neuromuscular physiology of the pelvic floor
Section III: Host environmental interaction. Tight junctions and the intestinal barrier
Gut barrier: adaptive immunity
Gut barrier: innate immunity
Chemosensing in the colon
Mucosal restitution and repair
Luminal chemosensing and mucosal defenses in the upper GI tract
Intestinal tuft cells
Section IV: Gut microbiome. Gastrointestinal microbial ecology with perspectives on health and disease
Diet effects on gut microbiome composition, function, and host physiology
Influence of the gut microbiome on immune development during early life
Gut microbiome and metabolism
Microbial physiology of the digestive tract and its role in inflammatory bowel diseases
Volume 2. Section V: Physiology of secretion. Salivary gland secretion
The cell biology of gastric acid secretion
Structure-function relationships in the pancreatic acinar cell
Regulation of pancreatic secretion
Bile formation and the enterohepatic circulation
Mechanisms of hepatocyte organic anion transport
Mechanisms of hepatocyte detoxification
Physiology of cholngiocytes
Section VI: Digestion and absorption. Molecular mechanisms of polarized protein trafficking in epithelial cells
Sugar absorption
Protein digestion and absorption
Enterocyte fatty acid handling proteins and chylomicron formation
Genetic regulation of intestinal lipid transport and metabolism
Digestion and intestinal absorption of dietary carotenoids and vitamin A
The vitamin D system: biological and molecular actions in the intestine and colon
Bioavailability of vitamin E
Intestinal absorption of vitamin K: cellular and molecular mechanisms
Intestinal absorption of water-soluble vitamins: cellular and molecular mechanisms
Water transport in the gastrointestinal tract
Na+/H+ exchange in mammalian digestive tract
Intestinal anion absorption
Ion channels of the gastrointestinal epithelial cells
Molecular mechanisms of intestinal transport of calcium, phosphate, and magnesium
Mechanisms and regulation of intestinal iron transport
Trace metal absorption and transport
Section VII: Integrated GI physiology and pathophysiology. The gastrointestinal tract and control of food intake
Mechanisms of helicobacter pylori-induced gastric inflammation
Host-pathogen interactions in pathophysiology of diarrheal disorders
Recruitment of inflammatory and immune cells in the gut
Mechanisms of gastrointestinal malignancies
Neuropathophysiology of the irritable bowel syndrome
Pathophysiology of diarrhea and its clinical implications