Books

Assembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology.

This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.

This easy-to-use guide helps parents with evidence-based advice for dealing with the most common issues facing babies and toddlers, including breastfeeding, baby care, developmental stages, first aid and injuries, sleep, vaccines and more.

Basic baby care -- Breastfeeding -- Formula feeding -- Beyond bottles and breastfeeding: starting solid foods -- Pooping -- Stomachaches and vomiting -- Fever -- Coughs, colds, and more -- Vaccines -- Skin -- Child care -- Ingestions, injuries, and first aid -- Growing up -- Sleep

This book provides a comprehensive resource for researchers and students involved with studying the roles of Bacilli in sustainable crop production technologies. Chapters included in the book not only elaborate on beneficial traits of Bacilli, but also highlight utilization of these microbes for producing industrially important antibiotics, enzymes, probiotics and other useful biochemicals. Feeding ever increasing world population from shrinking arable acreage led to a synthetic input (fertilizer, growth regulator, pesticide etc.) based crop production system, which has been creating both environmental and health hazards and may also make the whole production system unsustainable. Researchers, food producers and consumers alike, now realize that this world needs effective, environmentally smart agricultural technologies that are safe for people use less synthetic inputs and protect natural resources. To overcome the challenge of increasing food production with a significant reduction of agrochemicals use, a great deal of interest and research have been devoted to beneficial microorganisms/biostimulants in recent days with noteworthy positive results. Bacillus based biopesticide together with other bio-rational approaches may play a critical role in helping all the key drivers of sustainable, environmentally responsible food production with enhanced food quality. Although multiple strains of Bacillus spp. showed promise to contribute to the sustainable agriculture by making nutrients available to plants, providing additional defense to adverse abiotic and biotic stresses, research on Bacillus based product formulation, rate and crop selection, optimization of application timing are urgently needed. As crop plants are more vulnerable to abiotic and biotic stresses at the seedling stage, optimization of application timing should aid in alleviating those stresses for the successful completion of life cycle of a plant.

Intro -- Preface -- Contents -- Contributor List -- Part I: Background -- Chapter 1: Epidemiology of Pediatric Back Pain -- Introduction -- Defining Back Pain -- Prevalence -- Back Pain -- Neck and Thoracic Pain -- Low Back Pain -- Incidence -- Pain Frequency, Duration, and Intensity -- Disability -- Medical Attention -- Natural History -- Risk Factors -- Physical Domain -- Trunk Muscles -- Trunk Mobility -- Posture -- Trunk Asymmetry -- Muscle and Joint Flexibility -- Trunk Stability -- Biological Domain -- Weight and Height -- Gender -- Family History -- Lifestyle Domain -- Activity Sedentary Activity -- Physical Activity -- Sport -- Occupational Activity -- Sleep -- Smoking and Alcohol -- Backpacks -- Psychosocial Domain -- Psychological, Behavioral, and Cognitive Factors -- Social Factors -- Approaching Back Pain from a Multidimensional Perspective -- Prevention -- Brief Summary -- Conclusion -- Editor Discussion -- References -- Chapter 2: Anatomy of the Pediatric Spine -- Cervical Spine (Fig. 2.5) -- Thoracic Spine (Fig. 2.3) -- Lumbar Spine (Fig. 2.6) -- Editor Discussion -- References Chapter 3: Medical and Non-surgical Conditions That Can Cause or Contribute to Back Pain in a Child or Adolescent -- Mechanical Back Pain (Non-specific or Muscular Back Pain) -- Scoliosis -- Back Pain in Children with Neuromuscular Disease -- Muscle Strain and Spasm -- Spondylolysis/Spondylolisthesis -- Scheuermann Disease -- Degenerative Disease -- Bertolotti Syndrome -- Spinal Dysraphism -- Benign but Locally Aggressive Tumors of the Spine -- Osteoid Osteoma/Osteoblastoma -- Histiocytosis -- Malignancy -- Leukemia -- Ewing Sarcoma -- Spinal Cord Tumor -- Infection -- Discitis -- Osteomyelitis Systemic Disease -- Osteoporosis/Metabolic Bone Disease -- Sickle Cell Disease -- Spondyloarthropathy -- Extra-skeletal Causes of Back Pain -- Editor Discussion -- References -- Chapter 4: History Evaluation of the Child or Adolescent with Back Pain Including Ten Red Flags -- Introduction -- Summary -- Editor Discussion -- References -- Chapter 5: Physical Examination of the Child or Adolescent with Back Pain -- Editor Discussion -- References -- Chapter 6: Radiologic Imaging and Laboratory Evaluation of Back Pain in Children and Adolescents -- Introduction -- Imaging -- Role of Plain Radiography Radiation Exposure -- Special Views -- Role of Computerized Tomography (CT Scan) -- Spinal Cord Injury Without Radiographic Abnormality (SCIWORA) -- Technetium Nuclear Bone Scan -- PET-CT -- Imaging Findings on Plain Radiography -- Initial Approach to Reading Plain Radiographs of the Spine -- Disc Disease and Schmorl's Nodes -- Fracture or Dislocation -- Scheuermann's Kyphosis -- Transitional Vertebra -- Spina Bifida Occulta -- Spondylolysis and Spondylolisthesis -- Spinal Deformity -- Vertebra Plana -- MRI -- Examples of Commonly Encountered Pediatric Variations and Abnormalities

Using human skeletal remains, this volume traces health, workload and violence in the European population over the past 2,000 years. Health was surprisingly good for people who lived during the early Medieval Period. The Plague of Justinian of the sixth century was ultimately beneficial for health because the smaller population had relatively more resources that contributed to better living conditions. Increasing population density and inequality in the following centuries imposed an unhealthy diet - poor in protein - on the European population. With the onset of the Little Ice Age in the late Middle Ages, a further health decline ensued, which was not reversed until the nineteenth century. While some aspects of health declined, other attributes improved. During the early modern period, interpersonal violence (outside of warfare) declined possibly because stronger states and institutions were able to enforce compromise and cooperation. European health over the past two millennia was hence multifaceted in nature.

"When George Yancy penned a New York Times op-ed entitled 'Dear White America' asking white Americans to confront the ways that they benefit from racism, he knew his article would be controversial. But he was unprepared for the flood of vitriol in response. The resulting blowback played out in the national media, with critics attacking Yancy in every form possible--including death threats--and supporters rallying to his side. Despite the rhetoric of a 'post-race' America, Yancy quickly discovered that racism is still alive, crude, and vicious in its expression. In Backlash, Yancy expands upon the original article and chronicles the ensuing controversy as he seeks to understand what it was about the op-ed that created so much rage among so many white readers. He challenges white Americans to rise above the vitriol and to develop a new empathy for the African American experience."--Jacket.

v. 1. Structure -- v. 2. Metabolism -- v. 3. Biosynthesis -- v. 4. The Physiology of growth -- v. 5. Heredity -- v. 6 Bacterial diversity -- v. 7 Mechanisms of adaptation -- v. 8 Archaebacteria -- v. 10. The Biology of pseudomonas.

"In launching this book, we wanted to cover many aspects and mechanisms of cellular microbiology, but more importantly, we intended to show that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Many model organisms (Yersinia, Salmonella, Shigella, and Listeria, among others) are foodborne pathogens, and tremendous progress has been achieved in deciphering how, when, and where bacteria interact with the gut. However, intestinal cells and the intestine are not the only cells and organs discussed in this book. There are also chapters on infections of the urogenital tract, the endothelial barriers, the nervous system, and the lungs. Progress in the latter two concern important public health infections produced by Mycobacterium leprae and Mycobacterium tuberculosis. These two bacteria, which were at first much more difficult to manipulate than Escherichia coli, are now genetically tractable, and their study can now benefit from all the techniques and approaches established with less fastidious bacteria"-- Provided by publisher.

v. 1. Bacterial activities in perspective.--v. 2. Methods and special applications in bacterial ecology.

The proposed book aims to understand the mechanism of survival of microorganisms in response to chemical stress in various ecological niches that suffer direct human intervention, more so the agricultural, domestic and hospital settings. Microbicides (e.g. disinfectants, antiseptics, fungicides, algaecides, insecticides and pesticides) are used rampantly to control undesirable microbes. Insecticides and pesticides are routinely used in agriculture which directly affect the microbial population in farms, orchards and fields. Health care environments are always stressed with disinfectants and antibiotics. It is always probable that microbicide-stressed microorganisms are in a dynamic state, displaced from one niche to the other. Some soil and water borne bacteria or their resistance determinants are also getting prominence in hospital settings after suffering selective pressure from agricides. In order to reveal the survival strategies of microbicidal-resistant microbes, it is of prime importance to know the mode of action of these complete range of microbicides (agricides to antibiotics). The present book intends to address these issues. There will be several chapters dealing with tolerance and cross resistance in microbes and bacteria in particular, dwelling in various niches. Till date, there is no consensus among scientists in theorizing molecular mechanisms to explain bacterial tolerance and their cross resistance to agricides and antibiotics.

Bird's eye view of the bacterial landscape / Natividad Ruiz -- Visualizing the bacterial cell surface : an overview / Harald Engelhardt -- Purification of the outer membrane usher protein and periplasmic chaperone-subunit complexes from the P and type 1 pilus systems / Nadine S. Henderson and David G. Thanassi -- Experimental manipulation of the microbial functional amyloid called curli / Yizhou Zhou [and others] -- Visualization of gram-positive bacterial pili / Chungyu Chang [and others] -- Single cell microfluidic studies of bacterial motility / Adrien Ducret, Olivier Theodoly, and Tam Mignot -- Chromatographic analysis of the Escherichia coli polysialic acid capsule / Susan M. Steenbergen and Eric R. Vimr -- Analysis of exopolysaccharides in Myxococcus xanthus using confocal laser scanning microscopy / Wei Hu, Renate Lux, and Wenyuan Shi -- Assessment of multidrug efflux assemblies by surface plasmon resonance / Elena B. Tikhonova and Helen I. Zgurskaya -- Fluorescence microscopy and proteomics to investigate subcellular localization, assembly, and function of the type II secretion system / Tanya L. Johnson [and others] -- Pore formation by T3SS translocators : liposome leakage assay / Eric Faudry, Caroline Perdu, and Ina Attree -- Isolation of bacterial type IV machine subassemblies / Mayukh K. Sarkar [and others] -- Production and crystallization of bacterial type V secretion proteins / Hye-Jeong Yeo -- Assembly of bacterial outer membrane proteins / Jan Grijpstra, Martine P. Bos, and Jan Tommassen -- Outer membrane of gram-negative bacteria : lipid A isolation and characterization / Jessica V. Hankins [and others] -- Quantitative and qualitative preparations of bacterial outer membrane vesicles / Halima Chutkan [and others] -- In vitro peptidoglycan synthesis assay with lipid II substrate / Jacob Biboy, Nhat Khai Bui, and Waldemar Vollmer -- Extraction of cell wall-bound teichoic acids and surface proteins from Listeria monocytogenes / Filipe Carvalho [and others] -- Subfractionation and analysis of the cell envelope (lipo) polysaccharides of Mycobacterium tuberculosis / Anna E. Grzegorzewicz and Mary Jackson -- Protein disulfide bond formation in the periplasm : determination / Katleen Denoncin [and others] -- Using reporter genes and the Escherichia coli ASKA overexpression library in screens for regulators of the gram negative envelope stress response / Julia L. Wong, Stefanie L. Vogt, and Tracy L. Raivio -- Isolation of bacteria envelope proteins / Shu Quan [and others] -- Patch clamp electrophysiology for the study of bacterial ion channels in giant spheroplasts of E. coli / Boris Martinac [and others] -- Electrophysiological characterization of bacterial pore-forming proteins in planar lipid bilayers / Owen S. Mapingire, Beau Wager, and Anne H. Delcour.

This book provides an up-to-date overview of the architecture and biosynthesis of bacterial and archaeal cell walls, highlighting the evolution-based similarities in, but also the intriguing differences between the cell walls of Gram-negative bacteria, the Firmicutes and Actinobacteria, and the Archaea. The recent major advances in this field, which have brought to light many new structural and functional details, are presented and discussed. Over the past five years, a number of novel systems, e.g. for lipid, porin and lipopolysaccharide biosynthesis have been described. In addition, new structural achievements with periplasmic chaperones have been made, all of which have revealed amazing details on how bacterial cell walls are synthesized. These findings provide an essential basis for future research, e.g. the development of new antibiotics. The books content is the logical continuation of Volume 84 of SCBI (on Prokaryotic Cytoskeletons), and sets the stage for upcoming volumes on Protein Complexes.

1. Main metabolism -- 2. Brief overview of metabolic regulation of a bacterial cell -- 3. Metabolic regulation by global regulators in response to culture environment -- 4. Conventional flux balance analysis and its applications -- 5. 13C-metabolic flux analysis and its applications -- 6. Effect of a specific-gene knockout on metabolism.

Acute Poststreptococcal Glomerulonephritis -- Staphylococcus Infection-Associated Glomerulonephritis -- Glomerulonephritis Associated with Other Bacterial Infections -- Endocarditis-Associated Glomerulonephritis -- The Management of Bacterial Infection-Associated Glomerulonephritis -- Infection-Associated Thrombotic Microangiopathy -- Direct Bacterial Infection of the Renal Parenchyma: Pyelonephritis in Native Kidneys.

This book focuses on the multitude of functions bacterial membrane vesicles perform in bacterial ecology and pathogenesis as well as in emerging medical and biotechnological applications. Both Gram-negative and Gram-positive bacteria produce membrane-bound nanostructures, known as membrane vesicles, which have a range of functions that include serving as delivery vehicles, providing a means of communication over both spatial and temporal scales, and contributing to bacterial survival and evolution. Topics covered in this book range from the biogenesis and composition of bacterial membrane vesicles to their abundance and biological roles in microbial ecosystems, such as marine environments. In the individual chapters, the involvement of bacterial membrane vesicles in host-pathogen interactions, promoting virulence and in facilitating the establishment of infection is explained. In addition, current knowledge regarding membrane vesicles produced by commensal bacteria and their role in the maturation of the host immune system, as well as the therapeutic potential of bacterial membrane vesicles as delivery systems and innovative nanotechnology-based therapeutics are discussed. This work appeals to a wide readership of students and researchers interested in microbial ecology, mechanism underlying pathogenesis and new avenues in applied microbiology and nanotechnology.

Pulsed field gel electrophoresis and genome size estimates/ Rosa Alduina and Annalisa Pisciotta -- Comparative analyses of extrachromosomal bacterial replicons, identification of chromids, and experimental evaluation of their indispensability / Lukasz Dziewit and Dariusz Bartosik -- Choice of next-generation sequencing pipelines / F. Del Chierico ... [et al.] -- Pyrosequencing protocol for bacterial genomes / Ermanno Rizzi -- Bacterial metabarcoding by 16S rRNA gene ion torrent amplicon sequencing / Elio Fantini ... [et al.] -- Illumina-solexa sequencing protocol for bacterial genomes / Zhenfei Hu, Lei Cheng, and Hai Wang -- High-throughput phenomics / Carlo Viti ... [et al.] -- Comparative analysis of gene expression : uncovering expression conservation and divergence between Salmonella enterica serovar typhimurium strains LT2 and 14028S / Paolo Sonego ... [et al.] -- Raw sequence data and quality control / Giovanni Bacci -- Methods for assembling reads and producing contigs / Valerio Orlandini, Marco Fondi, and Renato Fani -- Mapping contigs using CONTIGuator / Marco Galardini, Alessio Mengoni, and Marco Bazzicalupo -- Gene calling and bacterial genome annotation with BG7 / Raquel Tobes ... [et al.] -- Defining orthologs and pangenome size metrics / Emanuele Bosi, Renato Fani, and Marco Fondi -- Robust identification of orthologues and paralogues for microbial pan-genomics using GET HOMOLOGUES : a case study of pIncA/C plasmids / Pablo Vinuesa and Bruno Contreras-Moreira -- Genome-scale metabolic network reconstruction / Marco Fondi and Pietro Liò -- From pangenome to panphenome and back / Marco Galardini, Alessio Mengoni, and Stefano Mocali -- Genome-wide detection of selection and other evolutionary forces / Zhuofei Xu and Rui Zhou -- Integrated microbial genome resource of analysis / Alice Checcucci and Alessio Mengoni.

Historical perspective on bacterial persistence / Natalie Verstraeten ... [et al.] -- Persisters : methods for isolation and identifying contributing factors-a review / Sarah E. Rowe ... [et al.] -- General method for measuring persister levels in Escherichia coli cultures / Niilo Kaldalu ... [et al.] -- Optimized method for measuring persistence in Escherichia coli with improved reproducibility / F. Goormaghtigh and L. Van Melderen -- Microplate-based system as in vitro model of biofilm growth and quantification / Ilse Vandecandelaere, Heleen Van Acker, and Tom Coenye -- Protocol for determination of the persister subpopulation in Candida Albicans biofilms / Katrijn De Brucker ... [et al.] -- Quantitative measurements of type I and type II persisters using ScanLag / Irit Levin-Reisman and Nathalie Q. Balaban -- Analyzing persister physiology with fluorescence-activated cell sorting / Mehmet A. Orman ... [et al.] -- Single-cell detection and collection of persister bacteria in a directly accessible femtoliter droplet array / Ryota Iino ... [et al.] -- Whole-cell-based high-throughput screening method to identify molecules targeting Pseudomonas Aeruginosa persister cells / Veerle Liebens, Valerie Defraine, and Maarten Fauvart -- Functional analysis of the role of toxin-antitoxin (TA) loci in bacterial persistence / Aaron T. Butt and Richard W. Titball -- Experimental evolution of Escherichia coli persister levels using cyclic antibiotic treatments / Bram Van den Bergh, Joran E. Michiels, and Jan Michiels -- In vitro models for the study of the intracellular activity of antibiotics / Julien M. Buyck ... [et al.] -- Murine model for Escherichia coli urinary tract infection / Thomas J. Hannan and David A. Hunstad -- Analysis of macrophage-induced Salmonella persisters / Robert A. Fisher, Angela M. Cheverton, and Sophie Helaine -- Population dynamics analysis of ciprofloxacin-persistent S. Typhimurium cells in a mouse model for Salmonella diarrhea / Patrick Kaiser, Roland R. Regoes, and Wolf-Dietrich Hardt -- Computational methods to model persistence / Alexandra Vandervelde ... [et al.].

Mapping the Escherichia coli transcription elongation complex with exonuclease III / Zhaokun Liu and Irina Artsimovitch -- Purification of bacterial RNA polymerase : tools and protocols / Vladimir Svetlov and Irina Artsimovitch -- Monitoring translocation of multisubunit RNA polymerase along the DNA with fluorescent base analogues / Anssi M. Malinen, Matti Turtola, and Georgiy A. Belogurov -- In vitro and in vivo methodologies for studying the sigma-54-dependent transcription / Martin Buck [and nine others] -- Methods for the assembly and analysis of in vitro transcription-coupled-to-translation systems / Daniel Castro-Roa and Nikolay Zenkin -- Site-specific incorporation of probes into RNA polymerase by unnatural-amino-acid mutagenesis and Straudinger-Bertozzi ligation / Anirban Chakraborty [and seven others] -- Reconstruction of factor-dependent, promotor proximal pausing in Drosophila nuclear extracts / Jian Li and David S. Gilmour -- Direct competition assay for transcription fidelity / Lucyna Lubkowska and Maria L. Kireeva -- Single-stranded DNA aptamers for functional probing of bacterial RNA polymerase / Danil Pupov and Andrey Kulbachinskiy -- Biochemical analysis of transcription termination by RNA polymerase III from yeast Saccharomyces cerevisiae / Aneeshkumar G. Arimbasseri and Richard J. Maraia -- Use of RNA polymerase molecular beacon assay to measure RNA polymerase interactions with model promotor fragments / Vladimir Mekler and Konstantin Severinov -- Preparation of cDNA libraries for high-throughput RNA sequencing analysis of RNA 5' ends / Irina O. Vvedenskaya, Seth R. Goldman, and Bryce E. Nickels -- In situ footprinting of E. coli transcription elongation complex with chloroacetaldehyde / A. Rachid Rahmouni and Christine Mosrin-Hauman -- Using solutes and kinetics to probe large conformational changes in the steps of transcription initiation / Emily F. Ruff, Wayne S. Kontur, and M. Thomas Record Jr. -- Manipulating archaeal systems to permit analyses of transcription elongation-termination decisions in vitro / Alexandra M. Gehring and Thomas J. Santangelo -- Purification of active RNA polymerase I from yeast / Francis Dean Appling and David Alan Schneider -- Transcription in archaea : preparation of Methanocaldococcus jannaschii transcription machinery / Katherine Smollet, Fabian Blombach, and Finn Werner -- Transcription in archaea ; in vitro transcription assays for mjRNAP / Katherine Smollet, Fabian Blombach, and Finn Werner -- Experimental analysis of hFACT action during pol II transcription in vitro / Fu-Kai Hsieh, Olga I. Kulaeva, and Vasily M. Studitsky -- ChIP-Seq for genome-scale analysis of bacterial DNA-binding proteins / Richard P. Bonocora and Joseph T. Wade.

One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogens benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.

This textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting "out-of-the-box" thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health. This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms.

This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology. The book introduces to bacteriophage biology, ecology and history and reviews the latest technologies and tools in bacteriophage detection, strain optimization and nanotechnology. Usage of bacteriophages in food safety, agriculture, and different therapeutic areas is discussed in detail. This book serves as essential guide for researchers in applied microbiology, biotechnology and medicine coming from both academia and industry.

Basic science/general medicine -- Rhinology and allergy -- General otolaryngology -- Laryngology -- Trauma -- Pediatric otolaryngology -- Head and neck surgery -- Sleep medicine -- Otology -- Facial plastic and reconstructive surgery -- Contemporary issues in medical practice.

Basic science general medicine -- Rhinology and allergy -- General otolaryngology -- Laryngology -- Trauma -- Pediatric otolaryngology -- Head and neck surgery -- Sleep medicine -- Otology -- Facial plastic and reconstructive surgery -- Contemporary issues in medical practice.

"Balance, Gait, and Falls, Volume 159 presents the latest information on sensorimotor anatomy, sensory integration, gravity and verticality, standing balance, balance perturbations, voluntary stepping and gait initiation, gait and gait adaptability, disorders of balance and gait that result from aging and neurological diseases. The book provides a brief overview of age-related changes in the structure and function of sensorimotor and central processes, with sections specifically devoted to Parkinson's disease, parkinsonism, cerebellar ataxia, stroke, corticobasal degeneration, multiple sclerosis, Huntington's disease, dystonia, tremor, Alzheimer's disease, frontotemporal dementia, cerebral palsy, polio, motor neuron disease, brainstem lesions, spinal lesions, peripheral nerve disease, and psychogenic conditions. Diseases covered have a common structure comprising background and epidemiology, pathology, balance disorders, gait disorders, falls, therapies (including fall prevention), and future directions"--Publisher's description.

Responding to public health challenges at the global and local levels can give rise to an array of tensions. To assure sustainable public health, these tensions need to be meaningfully balanced. Using empirical evidence and lived experiences relating to HIV from the global south, this book enunciates the many dimensions of national-level responses to HIV/AIDS including conceptual, philosophical, and methodological perspectives from public health, public policy, bioethics, and social sciences. Calling out glaring neglects, the book makes a bold recommendation for the destabilization of the naturalness with which national HIV/AIDS responses ignore the socio-political and medico-ethical dimensions of HIV. The case made is grounded in the philosophy of social public health. Such a critical perspective is not unique to Ghana's response to HIV/AIDS but serves as emblematic voice for similarly situated settings of the global south. The book is also timely. It is written at a time when public health actors are repositioning themselves to be competent users of not only pharmaceutic vaccines, but also social vaccines. Topics explored in the chapters include: Public health approaches to HIV and AIDS Access to life-saving public health goods by persons infected or affected by HIV "They are criminals" : AIDS, the law, harm reduction, and the socially excluded Developing socially and ethically responsive National AIDS policies Balancing the Socio-political and Medico-ethical Dimensions of HIV: A Social Public Health Approach is compelling reading for a broad spectrum of readers. The book will appeal to professionals, scholars, and students in public health, public policy, bioethics, and social sciences, as well as medical anthropologists, sociologists, and global health scholars. Public health economists, lay politicians, and civil society organizations advocating for health equity will find the book useful as well. .

This revised fourth edition provides a concise guide to the clinical and operational issues surrounding the management of the ballistic casualty. This book utilises the knowledge and experience acquired by those dealing with ballistic trauma on a regular basis to help those who manage these patients less regularly. This book is a valuable reference tool for all medical and paramedical personnel involved in the care of patients with ballistic injury. It is especially relevant for consultants and senior trainees in surgery, anesthesia, and emergency medicine who are likely to be involved in the management of these unique injuries.

The only curative treatment currently available for chronic thromboembolic pulmonary hypertension (CTEPH) is surgical pulmonary endoarterectomy (PEA). However, several patients may have high risk factors for surgery, or a peripheral disease not amenable to surgical treatment; or else a residual pulmonary hypertension after PEA. Balloon pulmonary angioplasty (BPA) was recently developed to offer an alternative treatment for these patients. Extensive data has since confirmed the efficacy and relative safety of this procedure. However, there are several technical issues that have yet to be resolved. In addition, many cardiologists and pneumologists still know very little about the procedure itself and its potential. Exploring the clinical indications and technical aspects of BPA, this book offers a valuable reference guide for all those who would like to introduce or improve a BPA program, and for all those whose work involves treating this complex patient population.

The [beta]-barrel assembly machinery complex / Denise L. Leyton, Matthew J. Belousoff, and Trevor Lithgow -- Yeast mitochondria as a model system to study the biogenesis of bacterial [beta]-barrel proteins / Thomas Ulrich [and three others] -- Experimental methods for studying the BAM complex in Neisseria meningitides / Martine P. Bos, Ria Tommassen-van Boxtel, and Jan Tommassen -- Heart modifiability of outer membrane proteins from gram-negative bacteria / Nicholas Noinaj, Adam J. Kuszak, and Susan K. Buchanan -- The role of a destabilized membrane of OMP insertion / Ashlee M. Plummer, Dennis Gessmann, and Karen G. Fleming -- Treponema pallidum in gel microdroplets: a method for topological analysis of BamA (TP0326) and localization of rare outer membrane proteins / Amit Luthra, Arvind Anand, and Justin D. Radolf -- Analyzing the role of periplasmic folding factors in the biogenesis of OMPs and members of the Type V secretion system / Gustavo Bodelón, Elvira Marín, and Luis Ángel Fernandez -- An in vitro assay for substrate translocation by FhaC in liposomes / Enguo Fan, Derrick Norell, and Matthias Müller -- Measuring cell-cell binding using flow-cytometry / Zachary C. Ruhe, Christopher S. Hayes, and David A. Low -- Methods to characterize folding and function of BamA cross-link mutants / Adam J. Kuszak, Nicholas Noinaj, and Susan K. Buchanan -- Small angle X-ray scattering (SAXS) characterization of the POTRA domains of BamA / Pamela Arden Doerner and Marcelo Carlos Sousa -- Assessing the outer membrane insertion and folding of multimeric transmembrane [beta]-barrel proteins / Jack C. Leo, Philipp Oberhettinger, and Dirk Linke -- The expression, purification, and structure determination of BamA from E. coli / Dongchun Ni and Yihua Huang -- Expression and purification of the individual Bam components BamB-E / Suraaj Aulakh, Kelly H. Kim, and Mark Paetzel -- Structure determination of the BAM complex accessory lipoproteins BamB-E / Kornelius Zeth -- An in vitro assay for outer membrane protein assembly by the BAM complex / Giselle Roman-Hernandez and Harris D. Bernstein -- Identification of BamC on the surface of E. coli / Chaille T. Webb and Trevor Lithgow -- Construction and characterization of an E. coli bamD depletion strain / Dante R. Ricci -- Expression, purification, and screening of BamE, a component of the BAM complex, for structural characterization / Mark Jeeves, Pooja Sridhar, and Timothy J. Knowles -- Purification and bicelle crystallization for structure determination of the E. coli outer membrane protein TamA / Fabian Gruss, Sebastian Hiller, and Timm Maier -- Strategies for the analysis of Bam recognition motifs in outer membrane proteins / Nagarajan Paramasivam and Dirk Linke -- Summary and future directions / Nicholas Noinaj and Susan K. Buchanan

"For 40 years, Bancroft's Theory and Practice of Histological Techniques has established itself as the standard reference for histotechnologists and laboratory scientists, as well as histopathologists. With coverage of the full range of histological techniques used in medical laboratories and pathology departments, it provides a strong foundation in all aspects of histological technology - from basic methods of section preparation and staining, to advanced diagnostic techniques such as immunocytochemistry and molecular testing. This revised and updated 8th Edition by Kim S. Suvarna, Christopher Layton, and John D. Bancroft is a one-stop reference for all those involved with histological preparations and applications, from student to highly advanced laboratory professional"--Publisher's description.

This is a brand new edition of the leading reference work on histological techniques. It is an resource suited to all those involved with histological preparations and applications, from the student to the highly experienced laboratory professional. New to this edition: Brand new co-editor. Self assessment questions and answers. Will help reinforce all of the basics in order to pass course exams, professional certification exams. New material on immunohistochemical and molecular diagnostic techniques. Enables user to keep abreast of latest advances in the field.

This book offers a detailed description of the main barbed pharyngoplasty techniques for the treatment of obstructive sleep apnea. These innovative techniques have spread in recent years and are considered as a validated alternative to the classic respective techniques. The book covers the barbed pharyngoplasty selection criteria, the surgical technique, and discusses the post-operative results. It also includes some chapters on the experience of surgical sleep centers in various parts of the world. Written by leading experts in the field of sleep surgery, this book will be interesting for ENT specialists, oral surgeons, maxillo-facial surgeons, plastic surgeons, sleep doctors, neurologists and pneumologists.

Bariatric and metabolic surgery is recognized to be an important and effective option for the treatment of severe obesity and the various associated conditions and diseases, such as type II diabetes, hypertension, cardiovascular dysfunction, dyslipidemia, and obstructive sleep apnea. Despite its established value, however, there is scope for further improvement in safety and in the quality of the surgical techniques, and calls have therefore been made for the establishment of standard techniques and procedures. This book accordingly presents state of the art knowledge on bariatric and metabolic surgery with the aim of facilitating the sharing and exchange of knowledge, documenting effective techniques, and enhancing safety and outcomes. All technical aspects are covered in detail, and the text is complemented by many helpful illustrations. A further key feature is the provision of accompanying surgical videos, which will be of value to both novice and experienced surgeons. This textbook will be a great asset in clinical practice for all who are involved or interested in bariatric and metabolic surgery.

This book describes the surgical bariatric procedures most frequently performed worldwide and examines their evolution in recent years both within Italy and internationally. For each operation, indications, the surgical technique, potential complications, and the outcomes with respect to weight and obesity-associated comorbidities are presented. In view of the significant failure rate revealed by studies on the long-term results of bariatric surgery, the problem of weight regain and revision surgery are also discussed in detail, covering the different types of revision, conversion to other procedures, and the main outcomes. In addition, individual chapters focus on selected topics of importance. The role of bariatric surgery in the cure of type 2 diabetes ("diabetes surgery") is discussed and the debate over the significance of gastroesophageal reflux disease and hiatal hernia for choice of procedure is summarized. Finally, the most common endoluminal procedures, which have been gaining in importance, are described and other bariatric operations, outlined.

To date, diet programs and medical therapies for the treatment of obesity have had limited success. Bariatric surgery, however, provides a means of effective weight loss for many of those with morbid obesity. Most of these weight loss procedures are performed with a variety of techniques that continue to evolve. Each technique is associated with unique challenges and complications and it is important for the clinician to be knowledgeable about the endoscopic management of these patients.

This book offers a step-by-step guide to mental health assessment for bariatric surgery patients. A general introduction explains the concepts of bariatric psychology and psychiatry, their relevance in contemporary bariatric surgery, and reasons to include psychologists and psychiatrists in multidisciplinary teams taking care of bariatric patients. The following four chapters address the aspects of mental health that are investigated by bariatric psychology. The psychological processes analyzed here play a major role in influencing patients' perception of the outcomes of bariatric surgery and in determining their commitment to lifestyle changes and follow-up programs. The second part of the book includes nine chapters addressing the clinical conditions relevant to bariatric psychiatry. For each condition, the major focus is on the impact of psychopathology on bariatric surgery outcomes (weight loss, weight regain, quality of life) and the impact of surgery on its course (remission, worsening, de novo onset). Each chapter in this part includes a discussion of the diagnostic instruments (i.e., structured interviews, clinician-rated tests, and patient-rated tests) that should be used to obtain a valid assessment of the patient's mental status. Separate chapters focus on psychiatric complications (e.g., suicide and addiction transfer) and psychological problems related to quality of life (e.g., body image dissatisfaction) that may emerge postoperatively. Data on these postsurgery conditions has been reported only recently and, therefore, no published book deals with them. The final chapter offers an overview of unsolved issues in bariatric psychology and psychiatry and reviews emerging research findings that are likely to change assessment and care of bariatric patients' mental health in the near future. Given its scope-and its wealth of tables, diagrams, mnemonics, and key fact boxes-the book will be an invaluable reference tool for clinicians.

The present book intends to provide a comprehensive guide on the field of robotic bariatric surgery. It covers all the stages to fulfill credentialing for performing robotic surgery, from an introduction to the robot device until comprehensive descriptions of surgical procedures. Also, robotic surgery is presented as an institutional program and we describe how to establish a robotic program in a hospital environment. The currently accepted and most common procedures – sleeve gastrectomy, gastric bypass and duodenal switch – are described in detail, with a step-by-step description of the techniques, followed by a wealth of photos and videos for each case. Special attention is given to the employment of robotic bariatric surgery in exceptional conditions, such as in super-obese patients, reoperations and revisional procedures. Critical issues, for the success of the robotic surgical interventions, such as anesthesia, are also addressed. Finally, the outcomes of robotic bariatric surgery are described, including long-term weight loss, improvement and resolution of comorbidities and improvement in quality of life. Bariatric Robotic Surgery is the first book specially devoted to this modality of surgical intervention. It is a fundamental tool for surgeons, residents and fellows who want to start a robotic bariatric surgery program. The book also helps experienced robotic surgeons to keep contact with the various available robotic surgical techniques. -- Provided by publisher.

Introduction and Overview of Current and Emerging Operations.-Anesthesia for the bariatric patient: optimizing safety and managing complications -- Optimizing perioperative management: Perioperative care & protocols to prevent & detect early complications -- Thromboembolic disease in the bariatric patient: Prevention, diagnosis and management -- Hemorrhage after bariatric surgery: evaluation and management -- Enteric Leaks after Gastric Bypass: Prevention and Management -- Enteric Leaks After Sleeve Gastrectomy: Prevention and Management -- Workup of abdominal pain in the gastric bypass and vertical sleeve gastrectomy patient -- Work-up of Abdominal Pain or Vomiting in the Gastric Band Patient -- Internal hernias: prevention, diagnosis & management -- Marginal and Peptic Ulcers: Prevention, Diagnosis, and Management -- Gastrointestinal Obstruction in the Bypass Patient -- Food intolerance in the sleeve patient: prevention, evaluation and management -- Gallstones and Common Bile Duct Stones in the Bariatric Surgery Patient: Surgical and Endoscopic Management -- Management of Abdominal Wall Hernias in the Bariatric Patient -- Band Prolapse: Diagnosis and Management -- Band erosion: surgical and endoscopic management -- Vertical Banded Gastroplasty: Evaluation and Management of Complications -- Inadequate Weight Loss after Bypass and Sleeve -- Failed weight loss after lap band surgery -- Post-Gastric Bypass Hypoglycemia: Diagnosis and Management -- Nutritional complications and emergencies -- Excessive Skin After Massive Weight Loss: Body Contouring and Bariatric Surgery -- The Psychological complications after bariatric surgery (eating disorders, substance abuse, depression, body image, etc.) -- Medical Malpractice in the 21st Century.

This book explores the clinical risks of obesity and how they can be prevented and resolved through vigorous treatment. The book covers the basic elements of bariatric surgery to ensure that non-specialist clinicians will be able to educate and advise patients on the treatment process. Corrections to current medical misconceptions surrounding bariatric surgery will give patients more realistic expectations of obesity treatment. This book aims to provide basic information to non-specialist general practitioners, nurses, and health care professionals, to aid in the management of obesity through lifestyle and behavioural therapy, as well as drugs and surgery. Diet, lifestyle treatments, drug therapy, dietary supplementation, and referral patterns are very different in post-operative individuals, and this book will allow patients to be given individualised treatment altered for each person's clinical needs. David Haslam is Chair of the National Obesity Forum (NOF) and a GP with a special interest in obesity and cardiometabolic disease, Physician in Obesity Medicine at the Centre for Obesity Research at Luton & Dunstable Hospital. Professor Haslam is Visiting Professor at the Robert Gordon University Aberdeen, and Visiting Professor at Chester University. He contributed to formulating the guidelines for adult obesity management in primary care and produced the first Primary Care guidelines for management of childhood obesity with the Royal College of Paediatrics and Child Health. Matt Capehorn founded and is a Clinical Manager and GPwSI at the Rotherham Institute for Obesity (RIO). RIO is a part of the award-winning NHS Rotherham Weight Management Strategy that won the 2009 NHS Health and Social Care Award for best commissioned service. Doctor Capehorn has been active on several local, regional and national advisory boards and regularly speaks at meetings to healthcare professionals, encouraging weight management services.

This book aims to deepen collaboration between gastroenterologists and surgeons by providing endoscopists and gastroenterologists with a clear understanding of the anatomic alterations likely to be observed after bariatric surgery and acquainting bariatric surgeons with the possibilities offered by endoscopic treatment of obesity itself and of the complications associated with bariatric surgery. The treatment approach in patients with obesity and morbid obesity is usually stepwise, starting with dietary measures, exercise, and behavioral therapy, followed by pharmaceutical therapies, endoscopic bariatric therapy, and, finally, bariatric surgery. Endoscopists and gastroenterologists are involved first because the gastrointestinal tract is affected by obesity-related co-morbidity and second because it provides access for a range of treatment modalities involving endoscopy. Bariatric surgeons may need the assistance of endoscopists and gastroenterologists in the preoperative work-up of patients, in the perioperative period, when acute complications may require an endoscopic intervention, or in the late follow-up period, when complications or insufficient weight loss may be present. This book will be of value for both groups of specialists, enabling them to optimize their cooperation to the benefit of patients.

This book presents the microscopic and macroscopic bark structure of more than 180 different tree and shrub species from Europe, Asia and North America. It is the first compendium to demonstrate the anatomical variability in bark since almost 70 years (Holdheide 1951). The introductory chapter explains with high-quality microphotographs the anatomical traits most important for identification and ecological interpretation of barks, and the monographic part demonstrates in text and pictures the species-specific patterns. The species treatments are grouped by their main biomes. Each species description first characterizes the macroscopic aspects with its main form, features and habitat with text and pictures of the whole plant and the barks in a young and old stage. This is followed by the microscopical description of each species. The microscopic photographs are based on double-stained slides, revealing the quality and distribution of unlignified and lignified tissues in low and high magnification. The book fills a scientific gap: Archeologists and soil scientists want to identify prehistoric and historical remnants. Ecophysiologists are interested in the distribution of conducting and non-conducting tissues in the phloem and xylem along the stem axis and the internal longevity of cells. Ecologists get information about internal defense mechanisms and technologists are enabled to recognize indicators relevant in biophysics and technology.

"With heart-shaped face, buff back and wings, and pure white underparts, the barn owl is a distinctive and much-loved bird that has fascinated people from many cultures throughout history. How did the barn owl colonize the world? What adaptations have made this bird so successful? How is the increasing impact of human disturbance affecting these animals? Answering these questions and more, Alexandre Roulin brings together the main global perspectives on the evolution, ecology and behaviour of the barn owl and its relatives, discussing topics such as high reproductive potential, physiology, social and family interactions, pronounced colour variation and global distribution. Accessible and beautifully illustrated, this definitive volume on the barn owl is for researchers, professionals and graduate students in ornithology, animal behaviour, ecology, conservation biology and evolutionary biology, and will also appeal to amateur ornithologists and nature lovers"-- Provided by publisher.

"This book summarizes the latest advances in the field, covering clinical presentation and features, diagnostic testing, current and new lab techniques, histologic appearances, and differential diagnoses of major skin diseases. For virtually every kind of skin lesion, this skill-sharpening resource has everything clinicians need to successfully perform differential diagnosis at the microscopic level. Barnhill's Dermatopathology features a systematic approach that cuts through the complexity of the discipline's traditional disease-oriented focus, providing a ready-to-use diagnostic approach that puts the entire world of dermatopathology into perspective. The book's vast scope encompasses all skin disease processes - inflammatory, non-inflammatory, infections, and proliferations (hamartomas, hyperplasias, and neoplasms, plus disorders of the nails, oral and genital mucosa, and conjunctiva). This fourth edition includes thoroughly updated and revised chapters ; new detailed appendices on laboratory methods, stains, and updated immunohistochemistry ; newly updated sections on various inflammatory conditions, infections, melanocytic, lymphoid, vascular, and other neoplastic conditions ; more than 1500 high-quality color images ; and two new chapters on disorders of the genital mucosa and tumors of the conjunctiva."-- Provided by publisher.

Inflammatory diseases of the epidermis -- Dermal based inflammatory diseases -- Vesiculobullous diseases -- Vasculitis and related disorders -- Inflammatory diseases of adnexal structures and subcutis -- Alterations to components of the epidermis and dermis -- Infectious diseases of the skin -- Tumors of the epidermis and cysts -- Adnexal tumors -- Melanocytic proliferations -- Tumors of mesenchymal origin -- Lymphoid, leukemic, and other cellular infiltrates.

In 1927, Zora Neale Hurston went to Plateau, Alabama, just outside Mobile, to interview eighty-six-year-old Cudjo Lewis. Of the millions of men, women, and children transported from Africa to America as slaves, Cudjo was then the only person alive to tell the story of this integral part of the nation's history. Hurston was there to record Cudjo's firsthand account of the raid that led to his capture and bondage fifty years after the Atlantic slave trade was outlawed in the United States. In 1931, Hurston returned to Plateau, the African-centric community three miles from Mobile founded by Cudjo and other former slaves from his ship. Spending more than three months there, she talked in depth with Cudjo about the details of his life. During those weeks, the young writer and the elderly formerly enslaved man ate peaches and watermelon that grew in the backyard and talked about Cudjo's past--memories from his childhood in Africa, the horrors of being captured and held in a barracoon for selection by American slavers, the harrowing experience of the Middle Passage packed with more than 100 other souls aboard the Clotilda, and the years he spent in slavery until the end of the Civil War. Based on those interviews, featuring Cudjo's unique vernacular, and written from Hurston's perspective with the compassion and singular style that have made her one of the preeminent American authors of the twentieth-century, Barracoon masterfully illustrates the tragedy of slavery and of one life forever defined by it. Offering insight into the pernicious legacy that continues to haunt us all, black and white, this poignant and powerful work is an invaluable contribution to our shared history and culture.

Chapter 6: Cryotherapy and Electrodesiccation & Curettage for Basal Cell Carcinoma Intro -- Preface -- Contents -- Contributors -- Editor Biographies -- Chapter 1: Epidemiology and Risk Factors of Basal Cell Carcinoma -- Epidemiology -- Introduction -- Geography -- Demographics -- Location and Histologic Subtype -- Morbidity and Mortality -- Economic Burden -- Prevention -- Risk Factors -- Introduction -- UV Radiation -- Photosensitizing Medications -- Ionizing Radiation -- Chemical Exposures -- Immunosuppression -- Genes -- Conclusion -- References -- Chapter 2: Pathophysiology of Basal Cell Carcinoma and Its Associated Genetic Syndromes -- Introduction Basal Cell Nevus Syndrome (BCNS) -- Bazex-Dupre-Christol Syndrome -- Rombo Syndrome -- Additional Genetic Syndromes with Increased Risk of Basal Cell Carcinoma -- References -- Chapter 3: Histopathology of Basal Cell Carcinoma and Its Variants -- Introduction -- Common Histologic Features -- Histologic Variants -- Nodular Basal Cell Carcinoma -- Superficial Basal Cell Carcinoma -- Infundibulocystic/Hamartomatous Basal Cell Carcinoma -- Fibroepithelioma of Pinkus -- Infiltrative Basal Cell Carcinoma -- Morpheaform Basal Cell Carcinoma -- Micronodular Basal Cell Carcinoma Clear Cell Basal Cell Carcinoma -- Adenoid Basal Cell Carcinoma -- Pleomorphic Basal Cell Carcinoma -- Keratotic Basal Cell Carcinoma -- Basal Cell Carcinoma with Matrical Differentiation -- Basal Cell Carcinoma with Ductal Differentiation -- Metaplastic Basal Cell Carcinoma -- High-Risk Features -- References -- Chapter 4: Topical Therapy for the Treatment of Basal Cell Carcinoma -- Introduction -- Background -- Mechanism of Action -- Imiquimod -- 5-Fluorouracil -- Ingenol Mebutate -- Efficacy -- Imiquimod -- 5-Fluorouracil -- Ingenol Mebutate -- Safety -- Imiquimod -- 5-Fluorouracil Ingenol Mebutate -- Comparative Studies -- Imiquimod -- Comparison of Different Treatment Regimens of Imiquimod to Vehicle Cream -- Comparison of Imiquimod to Other Treatment Modalities -- 5-Fluorouracil -- Ingenol Mebutate -- Emerging Topical Treatments and Combination Therapies -- Combination Therapies -- Imiquimod Plus CT -- Imiquimod Plus PDT -- Imiquimod Plus Curettage -- Imiquimod Plus MMS -- 5-FU Combination Therapy -- Discussion and Conclusions -- References -- Chapter 5: Local Immunotherapy for Basal Cell Carcinoma with Interferon -- Introduction -- Background Role of the Immune System -- Treatment with Immunostimulatory Agents (ISRX) -- Efficacy -- Low Recurrence Rate -- Normal Skin Markings -- Cosmesis -- Preservation of Function -- No Wound -- All Other Therapeutic Options Remain Open -- Disadvantages of ISRX -- Mechanism of Action of ISRX -- Patient/Tumor Selection -- Interferon Injections -- Preparation of IFN for Injection -- Injection Technique -- Dosage of IFN -- Combination of IFN with IMIQ -- Side Effects -- Recommended Follow-Up for BCC Treated with ISRX -- Conclusion -- References

This manual will help oral implantologists to understand the principles that underlie the use of basal implants as a means to provide simple solutions to complex and highly demanding clinical situations without the need for prior bone grafting. It will also serve as a richly illustrated practical guide to application of the technique. The book is in three parts, the first of which discusses basic principles and related themes, including osteogenesis, osseointegration, cortical anchorage stability, biomechanics, surgical techniques, and basal implant prosthodontics. Step-by-step guidance is then offered on the application of these principles, focusing on operating techniques, 3D treatment planning, transitional and final screw-secured prostheses, and postoperative follow-up. The third part of the book addresses a wide range of clinical situations that can be treated by basal implantology, with particular attention to the treatment of high, thin alveolar ridges and the atrophic maxilla and mandible and to the correction of previous implant failures. Potential complications and postimplantation neuropathies are also discussed, with guidance on their management.

Introduction to medical research -- Study designs in medical research -- Summarizing data & presenting data in tables & graphs -- Probability & related topics for making inferences about data -- Research questions about one group -- Research questions about two separate or independent groups -- Research questions about means in three or more groups -- Research questions about relationships among variables -- Analyzing research questions about survival -- Statistical methods for multiple variables -- Survey research -- Methods of evidence-based medicine and decision analysis -- Reading the medical literature.

This book provides detailed information on basic and advanced laboratory techniques in histopathology and cytology. It discusses the principles of and offers clear guidance on all routine and special laboratory techniques. In addition, it covers various advanced laboratory techniques, such as immunocytochemistry, flow cytometry, liquid based cytology, polymerase chain reaction, tissue microarray, and molecular technology. Further, the book includes numerous color illustrations, tables and boxes to familiarize the reader with the work of a pathology laboratory. The book is mainly intended for postgraduate students and fellows in pathology as well as practicing pathologists. The book is also relevant for all the laboratory technicians and students of laboratory technology.

The second edition of this well-received book provides detailed information on the basic and advanced laboratory techniques in histopathology and cytology. It offers clear guidance on the principles and techniques of routine and special laboratory techniques. It also covers advanced laboratory techniques such as immunocytochemistry, flow cytometry, liquid-based cytology, polymerase chain reactions, tissue microarray, molecular technology, etc. The book's second edition covers several important recent topics with many new chapters, such as liquid biopsy, artificial neural network, digital pathology, and next-generation sequencing. Each chapter elucidates basic principle, practical methods, troubleshooting, and clinical applications of the technique. It includes multiple colored line drawings, microphotographs, and tables to illustrate each technique. The book is a helpful guide to the post-graduate students and fellows in pathology, practicing pathologists, as well as laboratory technicians, and research students.

Section 1. Basic bone biology and physiology -- section 2. Assessment of bone structure and function -- section 3. Skeletal adaptation -- section 4. Hormonal and metabolic effects on bone -- section 5. Skeletal disease and treatment.

This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

Section I. Anatomy -- Section II. Physics, monitoring, and anesthesia delivery devices -- Section III. Principles of pharmacology -- Section IV. Clinical sciences -- Section V. Organ-based basic and clinical sciences -- Section VI. Professional challenges.

Peripheral processing -- Mosaic evolution of the mammalian auditory periphery -- A computer model of the auditory periphery and its application to the study of hearing -- A probabilistic account of absolute auditory thresholds and its possible physiological basis -- Cochlear compression: Recent insights from behavioural experiments -- Improved psychophysical methods to estimate peripheral gain and compression -- Contralateral efferent regulation of human cochlear tuning: Behavioural observations and computer model simulations -- Modeling effects of precursor duration on behavioral estimates of cochlear gain -- Is overshoot caused by an efferent reduction in cochlear gain? -- Accurate estimation of compression in simultaneous masking enables the simulation of hearing impairment for normal-hearing listeners -- Modelling the distortion produced by cochlear compression -- Temporal fine structure and pitch -- How independent are the pitch and the interaural-time-difference mechanisms that rely on temporal fine structure information? -- On the limit of neural phase-locking to fine-structure in humans -- Effects of sensorineural hearing loss on temporal coding of harmonic and inharmonic tone complexes in the auditory nerve -- A glimpsing account of the role of temporal fine structure information in speech recognition -- Assessing the possible role of frequency-shift detectors in the ability to hear out partials in complex tones -- Pitch perception: Dissociating frequency from fundamental-frequency discrimination -- Pitch perception for sequences of impulse responses whose scaling alternates at every cycle -- Putting the tritone paradox into context: insights from neural population decoding and human psychophysics -- Enhancement and perceptual compensation -- Spectral and level effects in auditory enhancement -- Enhancement of increments in spectral amplitude: further evidence for a mechanism based on central adaptation -- Differential sensitivity to appearing and disappearing objects in complex acoustic scenes -- Perceptual compensation when isolated test words are heard in room reverberation -- A new approach to sound source identification -- Binaural processing -- Maps of ITD in the Nucleus Laminaris of the Barn Owl -- The influence of the envelope waveform on binaural tuning of neurons in the inferior colliculus and its relation to binaural perception -- No evidence for ITD-specific adaptation in the frequency following response -- Interaural time difference thresholds as a function of frequency -- Interaural time processing when stimulus bandwidth differs at the two ears -- Neural correlates of the perception of sound source separation -- When and how envelope "rate-limitations" affect processing of interaural temporal disparities conveyed by high-frequency stimuli -- The sound source distance dependence of the acoustical cues to location and their encoding by neurons in the inferior colliculus: implications for the Duplex theory -- Cochlear contributions to the precedence effect -- Off-frequency BMLD: the role of monaural processing -- Measuring the apparent width of auditory sources in normal and impaired hearing -- Psychophysics of human echolocation -- Speech and temporal processing -- Formant-frequency variation and its effects on across-formant grouping in speech perception -- Do we need STRFs for cocktail parties? - On the relevance of physiologically motivated features for human speech perception derived from automatic speech recognition -- Modeling speech intelligibility in adverse conditions -- Better temporal neural coding with cochlear implants in awake animals -- Effects of auditory nerve refractoriness and adaptation on auditory perception -- Robust cortical encoding of slow temporal modulations of speech -- Wideband monaural envelope correlation perception -- Detection thresholds for amplitude modulations of tones in budgerigar (Melopsittacus undulatus) -- Phase discrimination ability in Mongolian gerbils provides evidence for possible processing mechanism of mistuning detection -- Auditory cortex and beyond -- Stimulus-specific adaptation beyond pure tones -- Mapping tonotopy in human auditory cortex -- Cortical activity associated with the perception of temporal asymmetry in ramped and damped noises -- Cortical representation of the combination of monaural and binaural unmasking -- Processing of short auditory stimuli: The Rapid Audio Sequential Presentation paradigm (RASP) -- Integration of auditory and tactile inputs in musical meter perception -- A dynamic system for the analysis of the acoustic features and valence of aversive sounds in the human brain -- Auditory scene analysis -- Can comodulation masking release occur when frequency changes would promote perceptual segregation of the on-frequency and flanking bands? -- Illusory auditory continuity despite neural evidence to the contrary -- High-acuity spatial stream segregation -- How early aging and environment interact in everyday listening: From brainstem to behaviour through modeling -- Energetic and informational masking in a simulated restaurant environment -- A computational model for the dynamic aspects of primitive auditory scene analysis -- A naturalistic approach to the cocktail party -- Temporal coherence and the streaming of complex sounds.

This edition has been significantly updated from the previous edition. The approach taken remains an integrated balance of qualitative and quantitative examples, applications, and problems designed to illustrate the principles discussed. The seventh edition also retains the important sensitivity to the fact that some beginning students of biomechanics possess weak backgrounds in mathematics. For this reason, it includes numerous sample problems and applications, along with practical advice on approaching quantitative problems. With balanced, integrated coverage of applied anatomy, mechanical principles, and relevant sport and daily living applications, this text introduces you to the basics of biomechanics. The quantitative aspects of biomechanics are presented in a manageable, progressive fashion, with practical advice on approaching both qualitative and quantitative problems in biomechanics.

Introductory Problems -- Additional Problems -- Laboratory Experiences -- 3 Kinetic Concepts for Analyzing Human Motion -- Basic Concepts Related to Kinetics -- Inertia -- Mass -- Force -- Center of Gravity -- Weight -- Pressure -- Volume -- Density -- Torque -- Impulse -- Mechanical Loads on the Human Body -- Compression, Tension, and Shear -- Mechanical Stress -- Torsion, Bending, and Combined Loads -- The Effects of Loading -- Repetitive versus Acute Loads -- Tools for Measuring Kinetic Quantities -- Vector Algebra -- Vector Composition -- Vector Resolution

"Biomechanics is a field that analyzes the mechanical aspects of biological organisms. In this book focused on human biomechanics, anatomical and mechanical factors, as well as functional applications are covered. The integrated approach to coverage of these areas taken in previous editions is continued in this ninth edition"-- Provided by publisher.

Detection of mycoplasma contaminations / Cord C. Uphoff and Hans G. Drexler -- Eradication of mycoplasma contaminations / Cord C. Uphoff and Hans G. Drexler -- STR DNA typing of human cell lines : detection of intra- and interspecies cross-contamination / Wilhelm G. Dirks and Hans G. Drexler -- Classical and molecular cytogenetic analysis / Roderick A.F. MacLeod and Hans G. Drexler -- Fluorescent in situ hybridization of DNA probes in the interphase and metaphase stages of the cell cycle / Linda A. Cannizzaro -- Development of T lymphocytes in fetal thymus organ culture / Takeshi Nitta, Izumi Ohigashi, and Yousuke Takahama -- Generation, isolation, and engraftment of in vitro-derived human T cell progenitors / Génève Awong and Juan Carlos Zúñiga-Pflücker -- In vitro generation of human T regulatory cells : generation, culture, and analysis of FOXP3-transduced T cells / Alicia N. McMurchy and Megan K. Levings -- Simultaneous cloning and selection of hybridomas and transfected cell lines in semisolid media / Bert Wognum and Tracy Lee -- Isolation and characterization of mouse side population cells / Aysegul V. Ergen [and others] -- Stem cell identification by DyeCycle violet side population analysis / William G. Telford -- Isolation and characterization of cancer stem cells in vitro / Craig Gedye and Laurie Ailles -- Ex vivo differentiation of cord blood stem cells into megakaryocytes and platelets / Nicolas Pineault [and others] -- Generation and characterization of murine alternatively activated macrophages / Shelley B. Weisser [and others] -- Human long-term culture initiating cell assay / Min Liu, Cindy L. Miller, and Connie J. Eaves -- Long-term culture-initiating cell assay for mouse cells / Stefan Woehrer, Cindy L. Miller, and Connie J. Eaves -- Colony forming cell assays for human hematopoietic progenitor cells / Bert Wognum [and others] -- Studying leukocyte recruitment under flow conditions / Sean A. Parsons [and others] -- Generation and establishment of murine adherent cell lines / Rouzanna Istvanffy and Robert A.J. Oostendorp -- Isolation, enumeration, and expansion of human mesenchymal stem cells in culture / Ravenska Wagey and Brenton Short -- Isolation and culture of mesenchymal stem cells from mouse compact bone / Brenton Short and Ravenska Wagey -- Generation of a pool of human platelet lysate and efficient use in cell culture / Katharina Schallmoser and Dirk Strunk -- In vitro methods to culture primary human breast epithelial cells / Afshin Raouf and Yu Jia Sun -- Human prostate epithelial cell cultures / Johng S. Rhim -- Enzymatic dissociation, flow cytometric analysis, and culture of normal mouse mammary tissue / Michael Prater [and others] -- Isolation and characterization of human hair follicle epithelial cells / Keita Inoue and Kotaro Yoshimura -- Cocultivation of human oral keratinocytes and human osteoblast-like cells / Ricarda Glaum and Margit Wiedmann-Al-Ahmad -- Isolation and culture of skeletal muscle myofibers as a means to analyze satellite cells / Paul Keire [and others] -- Hepatic differentiation of embryonic stem cells by murine fetal liver mesenchymal cells / Takamichi Ishii, Kentaro Yasuchika, and Iwao Ikai -- Methods to culture, differentiate, and characterize neural stem cells from the adult and embryonic mouse central nervous system / Sharon A. Louis, Carmen K.H. Mak, and Brent A. Reynolds -- Feeder-independent culture systems for human pluripotent stem cells / Jennifer Moody -- Formation of embryoid bodies from human pluripotent stem cells using AggreWell plates / Jennifer Antonchuk -- Techniques in embryoid body formation from human pluripotent stem cells / Nirupama K. Shevde and Amber A. Mael.

Part I. The Basics -- 1.History of Anesthesia -- 2.Preoperative Evaluation -- 3. Approach to Anesthesia -- 4. Perioperative Airway Management -- 5. Anesthesia Machine -- 6. Patient Monitoring -- 7. Fluid and Electrolyte balance -- 8. Transfusion Medicine -- Part II. Anesthetic Pharmacology -- 9. Mechanisms of Anesthetic Action -- 10. Inhalational Anesthetics -- 11. Intravenous Induction Agents -- 12. Opioids and Benzodiazepines -- 13. Neuromuscular blocking and reversal agents -- 14. Antiemetics -- 15. NSAIDs and Alpha-2 Adrenergic Agonists -- 16. Diuretics -- 17. Cardiovascular pharmacology -- 18. Local Anesthetics -- 19. Allergic reactions -- 20. Drug Interactions -- Part III. Regional Anesthesia -- 21. Spinal and Epidural Anesthesia -- 22. Peripheral nerve blocks -- 23. Ultrasound guided peripheral nerve blocks -- 24. Pain Management -- 25. Orthopedic Anesthesia -- Part IV. Specialty Anesthesia -- 26. Cardiac Anesthesia -- 27. Vascular Anesthesia -- 28. Ophthalmic Surgery -- 29. Neuroanesthesia -- 30. Ambulatory Anesthesia -- 31. Non-Operating Room Anesthesia -- 32. Hepatic and Gastrointestinal diseases -- 33. Renal and Urinary Tract Diseases -- 34. Endocrine diseases -- 35. Neurological and Neuromuscular Diseases -- 36. Ophthalmic Surgery -- 37. Ear, nose and throat surgery -- 38. Obstetric Anesthesia -- 39. Pediatric Anesthesia -- 40. Critical Care -- 41. Postoperative anesthesia care -- Part V. Special Anesthesia Topics -- 42. Obesity -- 43. The Elderly patient -- 44. Pulmonary Aspiration & Postoperative Nausea and Vomiting -- 45. Acid Base balance -- 46. Trauma -- 47. Spine Surgery -- 48. Robotic Surgery -- 49. Patient positioning and Common nerve injuries -- 50. Substance Abuse -- 51. Awareness under anesthesia -- 52. Infectious diseases -- 53. Alternative Medicine and Anesthesia -- 54. Cosmetic Surgery -- 55. Hazards of Working in the Operating Room -- 56. Operating room management -- 57. Residency Requirements and Guidelines.

Clinically oriented and student friendly, Basic Clinical Neuroscience provides the anatomic and pathophysiologic basis necessary to understand neurologic abnormalities. This concise but comprehensive text emphasizes the localization of specific medically important structures and clinically important pathways, using anatomy-enhancing illustrations. [From book jacket].

This book is a practical guidebook in biochemistry, for medical as well as life sciences' students. The book covers reference values, sample collection procedure and detailed protocol to perform experiments. Each experiment starts with a brief introduction of the protocol, followed by specimen requirements and procedure. The procedures are presented in a very lucid manner and discuss details of calculations and clinical interpretations, The book is divided into 29 chapters, It offers references, general guidelines and abbreviations and provides principles and procedures of clinical biochemistry tests, along with their diagnostic importance.

"Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class is a review book for pharmacology designed to help students organize and understand the hundreds of drugs covered in pharmacology classes today"-- Provided by publisher.

Basic Confocal Microscopy, Second Edition builds on the successful first edition by keeping the same format and reflecting relevant changes and recent developments in this still-burgeoning field. This format is based on the Confocal Microscopy Workshop that has been taught by several of the authors for nearly 20 years and remains a popular workshop for gaining basic skills in confocal microscopy. While much of the information concerning fluorescence and confocal microscopy that made the first edition a success has not changed in the six years since the book was first published, confocal imaging is an evolving field and recent advances in detector technology, operating software, tissue preparation and clearing, image analysis, and more have been updated to reflect this. Several of these advances are now considered routine in many laboratories, and others such as super resolution techniques built on confocal technology are becoming widely available.

1. Components of the electrocardiogram: the normal tracing -- 2. Axis -- 3. Myocardial infaction and ischemia -- 4. Atrioventricular (AV) block -- 5. Bundle branch blocks and hemiblocks -- 6. Chamber enlargement -- 7. Arrhythmias -- Index.

This significantly expanded second edition of this important textbook provides a comprehensive overview of the basics of electrocardiography. Each chapter is revised, and the book includes new chapters that focus on pacemakers, low voltage, pulmonary embolism, and hypothermia. The book is intended to help students in all health care delivery fields and at all levels of training to learn the basic concepts of interpreting electrocardiograms. It concisely covers the essential components of electrocardiography (ECG or EKG) and helps readers identify a number of conditions, including arrhythmias, bifascicular blocks, and heart attacks. Chapters are constructed to introduce basic themes, show examples from actual patient tracings, and provide practice through self-test electrocardiograms that reinforce the concepts taught in the chapter. Additionally, practice tracings build on the information provided in earlier chapters as well as on the features of the current one. Designed for the clerkship student, resident, or even the practicing professional who wants to brush up on EKG particulars, the second edition of Basic Electrocardiography is a user-friendly guide to one of medicine's most useful tools.

Focused and results-based, this important board review title covers everything that residents need to know when preparing for their Anesthesiology BASIC exam. Written by residents familiar with the exam, its use of bullet points and illustrations enables effective learning and efficient exam preparation. Providing a comprehensive review of all exam topics, the guide uses a clear and focused note-taking style to present 'high-yield' information, enabling efficient study techniques. Bullet points and short paragraphs feature to help rapid understanding, with margin space provided to annotate and add further notes. The helpful format ensures that all exam preparation, including notes from question banks, can be kept in this 'one-stop' review book. Mirroring the BASIC exam requirements, this book covers clinical anesthetic practice, pharmacology, physiology, anatomy, and anesthesia equipment and monitoring. Written by residents for residents, it is an essential preparation resource for the Anesthesiology BASIC exam.

This book reviews the assessment of human performance and the role of different exercise modes both in a laboratory and clinical setting. Details of how to successfully perform basic laboratory procedures for exercise training in health and disease, as well as how to apply non-invasive measurements in exercise physiology are provided. Chapters cover how to appropriately use a range of measures in assessing pulmonary function, anaerobic function and oxygen uptake. Techniques for cardiopulmonary rehabilitation and the mechanisms associated with thermoregulation are also described. Interactive exercises enable readers to easily assimilate key concepts and develop a thorough understanding of the topic. Basic Exercise Physiology provides both trainees and professional healthcare staff interested in exercise physiology with a detailed and practically applicable resource on the topic.

"Oral health education and promotion is an increasingly important topic in the dental industry, and oral health is integral to our general wellbeing. Oral health education involves practical, face-to-face expert instruction provided by a trained educator to a patient, with specific goals in both preventing oral conditions and diseases and managing pre-existing conditions. Promotion is concerned with making people aware of oral health issues on a local, national and international level through initiatives and programmes. Both education and promotion have the same objective -- to help people achieve and maintain good oral health"-- Provided by publisher.

v. 1. Development / Justin D. Call ... [et al.], editors -- v. 2. Disturbances in development / Joseph D. Noshpitz, editor -- v. 3. Therapeutic interventions / Saul I. Harrison, editor -- v. 4. Prevention and current issues / Irving N. Berlin and Lawrence A. Stone, editors -- v. 5. Advances and new directions / Justin D. Call ... [et al.].

Introduction to the immune system : nomenclature, general properties, and components -- Innate immunity : the early defense against infections -- Antigen presentation to t lymphocytes and the functions of major histocompatibility complex molecules : what t lymphocytes see -- Antigen recognition in the adaptive immune system : structure of lymphocyte antigen receptors and development of immune repertoires -- T cell ⁰́₃mediated immunity : activation of t lymphocytes -- Effector mechanisms of t cell ⁰́₃mediated immunity : functions of t cells in host defense -- Humoral immune responses : activation of b lymphocytes and production of antibodies -- Effector mechanisms of humoral immunity : elimination of extracellular microbes and toxins -- Immunologic tolerance and autoimmunity : self⁰́₃nonself discrimination in the immune system and its failure -- Tumor and transplantation immunology : immune responses to cancer cells and normal foreign cells -- Hypersensitivity : disorders caused by immune responses -- Immunodeficiency diseases : disorders caused by defective immunity.

This book provides a unique introduction to the vast field of Medical Imaging Informatics for students and physicians by depicting the basics of the different areas in Radiology Informatics. It features short chapters on the different main areas in Medical Imaging Informatics, such as Picture Archiving and Communication Systems (PACS), radiology reporting, data sharing, and de-identification and anonymization, as well as standards like Digital Imaging and Communications in Medicine (DICOM), Integrating the Health Enterprise (IHE) and Health Level 7 (HL7,. Written by experts in the respective fields and endorsed by the European Society of Medical Imaging Informatics (EuSoMII) the scope of the book is based on the Medical Imaging Informatics sub-sections of the European Society of Radiology (ESR) European Training Curriculum Undergraduate Level and Level I. This volume will be an invaluable resource for residents and radiologists and is also specifically suited for undergraduate training.

This is the perfect pharmacology textbook for medical and pharmacy students. The book was developed on the +30-year experience of the author as pharmacology professor in the United States and Germany. The book discusses the most important drugs (400) in the context of relevant diseases. Summary tables and schemes, MCQ exam questions, case studies and a list of drugs aid memorization of the material before an exam. All chapters are written in the same concise style and use a modern and precise pharmacological nomenclature. After reading of the book, the student will be able to critically assess the proper use of the most important drugs and advise patients properly. The didactic concept of the book has been developed on the authors own pharmacology courses for which he has received numerous teaching awards. The book takes advantage of the learning spiral, in which material is presented repeatedly from various angles. This book is an adaptation for an international audience of the German textbook "Basiswissen Pharmakologie" (2018); ISBN: 978-3-662-56303-8.

Consists of the proceedings of international Latin American symposia.

pt. 1. General concepts -- Introduction -- High-quality CPR -- The chain of survival -- Cardiac arrest or heart attack? -- pt. 2. BLS for adults -- BLS general concepts -- BLS healthcare provider adult cardiac arrest algorithm -- Adult 1-rescuer BLS sequence -- Adult chest compressions -- Adult breaths -- Opening the airway -- Barrier devices -- Bag-mask devices -- Adult 2-rescuer BLS sequence -- Team roles and duties for 2-rescuer CPR -- pt. 3. Automated external defibrillator for adults and children 8 years of age and older -- General concepts -- Using the AED -- Special circumstances -- pt. 4. Team dynamics -- General concepts -- Elements of effective team dynamics -- Roles during a resuscitation attempt -- What to communicate -- How to communicate -- Debriefing -- pt. 5. BLS for infants and children -- General concepts -- BLS healthcare provider pediatric cardiac arrest algorithm for the single rescuer -- Infant and child 1-rescuer BLS sequence -- Infant/child chest compressions -- Infant/child breaths -- BLS healthcare provider pediatric cardiac arrest algorithm for 2 or more rescuers -- Infant and child 2-rescuer BLS sequence -- pt. 6. Automated external defibrillator for infants and for children less than 8 years of age -- AED for infants and children -- pt. 7. Ventilation techniques -- CPR and breaths with an advanced airway -- Rescue breathing -- Techniques for giving breaths without a barrier device -- pt. 8. Opioid-associated life-threatening emergencies -- General concepts -- Opioid-associated life-threatening emergency (adult) sequence -- pt. 9. Choking relief for adults, children, and infants -- General concepts -- Choking relief in a responsive adult or child -- Choking relief in an unresponsive adult or child -- Choking relief in infants -- Summary of high-quality CPR components for BLS providers -- Adult CPR and AED skills testing checklist -- Adult CPR and AED skills testing critical skills descriptors -- Infant CPR skills testing checklist -- Infant CPR skills testing critical skills descriptors.

The BLS Provider Manual eBook is the electronic equivalent of the AHA's BLS Provider Manual. It offers an alternative to the printed course manual and is for use by a single student before, during and after the BLS Course. Please note, there is a separate supplementary tool included, the BLS Digital Reference Card. This is the electronic equivalent of the BLS Reference Card, and will be automatically included with the purchase of the BLS Provider Manual eBook.

"This manual informs about practical procedures in ... assessment based on experience from existing national fluoridation programmes. The assessment tools will primarily be useful in assisting countries in achieving an effective fluoride exposure. It is a hope that the manual will stimulate oral health personnel and public health administrators to use a systematic approach for managing and analysing data obtained from different levels of fluoride exposure. Finally the manual encourages inter-country collaboration on surveillance systems for community programmes using fluoride for prevention of dental caries."--Publisher's description.

This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS.

This book provides an evidence-based, practical approach to the diagnosis and treatment of the most frequent fungal infections in a general hospital. It offers a comprehensive overview of the basic medical and scientific background of fungal infections and carefully explains and discusses epidemiology, pathogenesis, and clinical presentation. Readers will acquire a good and clear perception of invasive fungal infections, including diagnosis and treatment. This user-friendly resource not only serves as a valuable tool in clinical management, but also provides the basis for further research questions and studies in this particular field. It will be a useful companion for midwives as well as for doctors, medical and pharmacy students, nurses and other healthcare professionals.

Addresses the fundamental principles and techniques of general diagnostic and advanced musculoskeletal imaging. This book focuses on the conditions and procedures most often encountered in real-world practice, such as: Upper and lower extremity trauma; axial skeletal trauma; arthritis and infection; tumors; and metabolic bone diseases.

"Basic Musculoskeletal Imaging is an easy-to-read teaching textbook that is primarily targeted to medical students and residents in radiology, orthopedics, and physical therapy and rehabilitation that addresses the basic aspects of not only general diagnostic but also advanced imaging of musculoskeletal radiology"-- Provided by publisher.

Expressly designed for surgeons in training who are new to nasal rhinoplasty, this textbook is written in a simple didactic style. A century after the first open rhinoplasty was performed by Dr. Aurel Réthi in Hungary, open rhinoplasty is now the most commonly used approach to aesthetic and reconstructive nasal surgery; the author's decades of experience will safely guide the reader through her/his journey from the first contact with new patients to the postoperative analysis of clinical results. Instead of the usual classification of surgical techniques and anatomical regions, here the learning process is based on a sequence of steps, each of which addresses the most frequent problems that surgeons are likely to encounter in everyday clinical practice. In addition, the most relevant surgical instruments and electromedical devices are presented, together with their specific features and techniques, such as inclination and positioning during the procedure. Each step is richly illustrated and supported by a suggested reading list, as well as content on ethical and general principles. A specific chapter on radiological pre-evaluation assessment makes this book unique. Given its clear structure, its appealing didactic style and wealth of figures, Basic Open Rhinoplasty offers a much-valued step-by-step companion for postgraduate students, surgeons in training, and medical practitioners who deal with rhinoplasty in their clinical practice.

Anatomy, physiology, and immunology of the nose, paranasal sinuses, and face / Gerhard Grevers -- Diagnostic evaluation of the nose and paranasal sinuses / Gerhard Grevers -- Diseases of the nose, paranasal sinuses, and face / Gerhard Grevers -- Lips and oral cavity / Gerhard Grevers -- Pharynx and esophagus / Gerhard Grevers -- The salivary glands / Rudolf Probst, Heinrich Iro, Frank Waldfahrer -- Anatomy and physiology of the ear / Rudolf Probst -- Audiology (hearing tests) / Rudolf Probst -- Pediatric hearing disorders, pediatric audiology / Rudolf Probst -- External ear / Rudolf Probst -- Middle ear / Rudolf Probst -- Inner ear and retrocochlear disorders / Rudolf Probst -- Vestibular disorders / Rudolf Probst -- Facial nerve / Rudolf Probst -- Lateral skull base / Rudolf Probst -- External neck / Heinrich Iro, Frank Waldfahrer -- Larynx and trachea / Heinrich Iro, Frank Waldfahrer -- Voice disorders / Frank Rosanowski, Ulrich Eysholdt -- Speech and language disorders / Frank Rosanowski, Ulrich Eysholdt.

Every trainee in anaesthesia requires a thorough understanding of basic physiology and its application to clinical practice. Now in its second edition, this comprehensively illustrated textbook bridges the gap between medical school and reference scientific texts. It covers the physiology requirements of the Primary FRCA examination syllabus. Chapters are organised by organ system, with particular emphasis given to the respiratory, cardiovascular and nervous systems. The practical question-and-answer format helps the reader prepare for oral examinations, while 'clinical reference' boxes translate the physiological concepts to clinical practice. This new edition has been thoroughly updated and revised throughout, and includes six new chapters including the physiology of the eye, upper airway and exercise testing. It provides junior anaesthetists with an essential 'one stop' physiology resource.

This book is a comprehensive and authoritative text on the subject of cardiovascular magnetic resonance (CMR). Imaging experts from the most medically advanced areas of the world discuss the basic principles of this modality in detail while maintaining a focus on the needs of cardiovascular imagers who wish to learn more about this subject but do not have a strong background in physics. CMR is now considered a clinically important imaging modality for patients with a wide variety of cardiovascular diseases. Recent developments have influenced a wide variety of cardiovascular imaging applications, many of which are now routinely used in clinical practice in CMR laboratories around the world. That it is non-invasive and lacks ionizing radiation exposure make CMR uniquely important for patients whose clinical condition requires serial imaging follow-up. Basic Principles of Cardiovascular MRI: Physics and Imaging Techniques includes a wealth of CMR examples in the form of high-resolution still images. Each imaging technique is discussed in separate chapters that include the physics and clinical applications (with cardiovascular examples) of that particular technique. As such, this book will be essential for cardiovascular medicine specialists and trainees , cardiovascular physicists, and clinical cardiovascular imagers.

This updated work is an all-in-one book, encompassing the essential aspects of radiation physics, radiobiology, and clinical radiation oncology. A complete section is devoted to each of these fields. In the first two sections, concepts that are crucial in radiation physics and radiobiology are reviewed in depth. The third section describes radiation treatment regimens appropriate for the main cancer sites and tumor types. The book has been designed to ensure that the readers will find it easy to use. Many "pearl boxes" are used to summarize the most information, and there are more than 350 helpful illustrations, the majority of them in color. Basic Radiation Oncology, 2nd edition, will meet the need for a practical, up-to-date, bedside-oriented radiation oncology book. It will be extremely useful for residents, fellows, and clinicians in the fields of radiation, medical, and surgical oncology, as well as for medical students, physicians, and medical physicists with an interest in clinical oncology.

This book is a concise and well-illustrated review of the physics and biology of radiation therapy intended for radiation oncology residents, radiation therapists, dosimetrists, and physicists. It presents topics that are included on the Radiation Therapy Physics and Biology examinations and is designed with the intent of presenting information in an easily digestible format with maximum retention in mind. The inclusion of mnemonics, rules of thumb, and reader-friendly illustrations throughout the book help to make difficult concepts easier to grasp. Basic Radiotherapy Physics and Biology is a valuable reference for students and prospective students in every discipline of radiation oncology.

This book is a concise and well-illustrated review of the physics and biology of radiation therapy intended for radiation therapists, dosimetrists, radiation oncology residents, and physicists. It presents topics that are included on the radiation therapy physics and biology board examinations and is designed with the intent of presenting information in an easily digestible format with maximum retention in mind. The inclusion of mnemonics, rules of thumb, and reader-friendly illustrations throughout the book help to make difficult concepts easier to grasp. This new edition is updated throughout with the latest information and applications of radiation oncology physics and biology and includes four new chapters. New topics include: MRI linac, proton beam radiotherapy, chemomodulation and immunomodulation of radiation in vitro and in vivo, and stochastic and deterministic late effects. Basic Radiotherapy Physics and Biology is a valuable reference for radiation oncologists, medical professionals in the field, residents, and all students interested in radiation oncology.

v. 1. Basis and development of reproduction.--v. 2. Reproduction function in men.--v. 3. Reproductive function in women.--v. 4. Pregnancy.--v. 5. Diseases of women.

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.

"Covers cancer causation, cancer biology, and the biology underlying cancer treatment, for trainees in both clinical and research areas of oncology"-- Provided by publisher

This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.

What Is Light? -- The Interaction Between Light and Matter -- Light Sources -- Examinations with Light -- Ultrasound Diagnostics -- Further Imaging Procedures -- Interventions with Laser Light -- Some History of Chemistry -- Oxygen -- Water -- Carbon Dioxide (CO2) -- Nitric Oxide -- Redox Reactions -- DNA -- RNA -- Proteins -- Lipids -- Matter: Using Water as an Example -- If You Are Interested in More ... -- Appendix: Units and Constants.

Part I Physics and Chemistry of Nuclear Medicine: Basic Radiation Physics -- Radiation Safety in Nuclear Medicine -- Non-imaging instrumentation in NM -- Quality assurance and quality control of Tc-99m Radiopharmaceuticals -- Tc99m Radio Chemistry -- Radiopharmaceuticals for Diagnosis and Therapy -- PET Chemistry: An Introduction -- PET Chemistry: Radiopharmaceuticals -- Radiation Dosimetry -- Part II SPECT and PET Imaging Instrumentation: Elements of gamma camera and SPECT systems -- Quality Control of planar and SPECT Imaging systems -- Positron Emission Tomography (PET): Basic principles -- CT in Hybrid SPECT/CT and PET/CT -- Part III Image Analysis, Reconstruction and Quantitation in Nuclear Medicine: Fundamentals of Image Processing In Nuclear Medicine -- Emission Tomography and Image Reconstruction -- Quantitative SPECT imaging -- Basic Principales of Radiomics -- Quantitative Cardiac SPECT Imaging -- Tracer Kinetic Modeling: Basics and Concepts -- Tracer Kinetic Modeling: Methodology and Applications.

This book provides detailed descriptions of fundamental techniques that may be employed for extremity reconstruction and distraction osteogenesis in accordance with the principles established by Gavriil Abramovich Ilizarov. Techniques of proven value for deformity correction, limb lengthening, reconstruction of post-traumatic and post-osteomyelitis bone defects, non-union surgery, and fracture fixation with external fixators are thoroughly described step by step with the aid of a wealth of illustrative material. In addition, indications and preoperative planning are clearly explained. Throughout, care is taken to highlight important technical tips and tricks as well as clinical pearls and pitfalls. Since the first description of distraction osteogenesis by Ilizarov in the 1950s, numerous technical improvements have been made and new devices, developed, even though the basic principles have remained the same. This new book will be of value for both novice and more experienced surgeons who use distraction osteogenesis for the purpose of extremity reconstruction.

Part A. Basic surgical techniques -- Part B. Head and neck -- Part C. Spine and limbs -- Part D. Thorax -- Part E. Abdomen -- Part F. Groin and genitalia -- Part G. Urology -- Part H. Perineum -- Part I. Minimally invasive surgery -- Appendix. Training in paediatric surgery -- Subject Index.

This book supplies all the information that the young orthopaedic surgeon needs to know when preparing to perform total or partial knee replacement for the first time and also provides more experienced surgeons with a comprehensive general update on the basics. After an opening section on anatomy and kinematics of the knee, patient management during the pre-, peri-, and postoperative phases is covered in detail with the aid of numerous illustrations. The final section considers postoperative patient evaluation, outcome measurements, and the value of registries. Readers will gain a sound understanding of the scientific basis underlying management decisions, of component design philosophies, and of the rationale for preferences such as mechanical alignment and ligament balancing. The pros and cons of a variety of management choices are explained, and guidance provided on patient selection. Surgical techniques are presented on high-quality videos and many tips and tricks are highlighted to help the inexperienced to cope with challenging situations.

What is anesthesiology? -- How to have an amazing anesthesiology rotation -- Smart questions to ask -- OR anesthesia basics -- The preoperative evaluation -- What happens in the OR from the anesthesiologist's perspective? -- The airway: anatomy, assessment, management -- Important pharmacology/medications to know -- Anesthesiology emergencies

"This book provides patients and their physicians (especially "non-oncologist" health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient's own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are:Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today's daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors' expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease."-- Provided by publisher.

This book covers interventional treatments (minimally invasive therapies) for the management of various hepato-biliary disorders and the complications arising due to liver cirrhosis and portal hypertension. Given that interventional radiology and hepato-biliary interventions are comparatively new, very little literature is available on them. This book addresses that gap and offers practitioners and trainees a guide to the management of various hepato-biliary disorders requiring radiological interventions. The content addresses both non-vascular and vascular procedures. The respective chapters cover various procedures, such as image guided diagnostic tissue sampling (FNA and biopsies), guided liver abscess and biliary drainage procedures, liver tumor ablation, intra-arterial and intravenous techniques for the management of vascular diseases of the liver and portal hypertension, variceal bleeds and tumor management. Last but not the least, detailed chapters on interventions for post liver transplant complications are also included. The book is chiefly intended for practicing interventional radiologists, as well as fellows and trainees in interventional radiology courses.

This book is a practical and easily understandable guide for mechanical ventilation. With a focus on the basics, this text begins with a detailed account of the mechanisms of spontaneous breathing as a reference point to then describe how a ventilator actually works and how to effectively use it in practice. The text then details: the various modes of ventilation commonly used in clinical practice; patient-ventilator interactions and dyssynchrony; how to approach a patient on the ventilator with respiratory decompensation; the optimal ventilator management for common disease states like acute respiratory distress syndrome and obstructive lung disease; the process of ventilator weaning; and hemodynamic effects of mechanical ventilation. Written for medical students, residents, and practicing physicians in a variety of different specialties (including internal medicine, critical care, surgery and anesthesiology), this book will instruct readers on how to effectively manage a ventilator, as well as explain the underlying interactions between it and the critically ill patient.

Introduction -- Understanding Accreditation and Certification in Musculoskeletal Ultrasound -- Choosing Ultrasound Equipment -- Knobology -- Tissue Scanning -- Hand and Fingers -- Wrist -- Elbow -- Shoulder -- Foot and Toes -- Ankle -- Knee -- Hip -- Groin -- Ultrasound Guidance of Injections -- Rheumatologic Findings.

The field of musculoskeletal ultrasound has rapidly advanced in the past several years. The scanning protocols in particular have become more sophisticated and more standardized. Now in its fully revised and expanded second edition, this volume is the definitive resource on musculoskeletal ultrasound for the beginning practitioner. A new, first of its kind chapter has been added on ultrasound in Sports Medicine Emergencies. This expands the book topic from using POCUS as an office tool to its use on the athletic field to assist with emergencies. This new and detailed chapter includes the acute evaluation of an eye injury, lung, Morrison's pouch, IV access, fluid status, soft tissue and DVT protocols. Conforming to an identical chapter format, all previous chapters have been expanded and updated. Images have been reformatted to larger, clearer versions in addition to probe placement images going from black and white to full color. This book is divided into five different sections. It begins with chapters on the upper extremity such as the hand and wrist. The next section focuses on the lower extremity such as the foot and knee. The third section is nerve based and describes brachial plexus and major peripheral nerves. The fourth section covers Sports Medicine POCUS Emergencies. The last section details specific procedures such as I&D of abscess and hydrodissection. Each chapter follows a standard structure. They open with an approach to the patient, which contains the main pathology and clinical exam. The surface anatomy and ultrasound-based anatomy are then addressed. A discussion on patient positioning and probe settings follows. Pearls, pitfalls and red flags offer tips and pointers on scanning techniques as well as pathology not to be missed. Finally, each chapter is closed out with a summary report. Basics of Musculoskeletal Ultrasound, 2e is a must-have reference for residents, fellowship directors, fellows and primary care physicians as well as athletic trainers, physician assistants, physical therapists and ultrasound technicians. It is also an excellent resource for participants of the AMSSM MSK ultrasound courses.

Approaching a cancer patient -- Principles of application of radiotherapy -- Use of ither agents with radiation -- Managing radiotherapy complications.

Inspiration and background -- Theoretical foundations -- Practical considerations for getting started -- Prelude to analysis -- Strategies for qualitative data analysis -- Memos and diagrams -- Theoretical sampling -- Context -- Process -- Techniques for achieving theoretical integration -- The use of computer programs in qualitative data analysis -- Open coding: identifying concepts -- Developing concepts in terms of their properties and dimensions -- Analyzing data for context -- Bringing process into the analysis -- Integrating categories -- Writing theses, monographs, and dissertations, and giving talks -- About your research -- Criteria for evaluation -- Student questions and answers.

This book is designed as a comprehensive educational resource not only for basketball medical caregivers and scientists but for all basketball personnel. Written by a multidisciplinary team of leading experts in their fields, it provides information and guidance on injury prevention, injury management, and rehabilitation for physicians, physical therapists, athletic trainers, rehabilitation specialists, conditioning trainers, and coaches. All commonly encountered injuries and a variety of situations and scenarios specific to basketball are covered with the aid of more than 200 color photos and illustrations. Basketball Sports Medicine and Science is published in collaboration with ESSKA and will represent a superb, comprehensive educational resource. It is further hoped that the book will serve as a link between the different disciplines and modalities involved in basketball care, creating a common language and improving communication within the team staff and environment.

Paradigm shifts in mast cell and basophil biology and function : an emerging view of immune regulation in health and disease / Ana Olivera and Juan Rivera -- Purification of basophils from peripheral human blood / Franco H. Falcone and Bernhard F. Gibbs -- Mast cell purification protocols / Jasmine Farrington , Elizabeth P. Seward , and Peter T. Peachell -- Generation of a human allergic mast cell phenotype from CD133+ stem cells / Hans Jürgen Hoffmann -- Generation of mast cells from murine stem cell progenitors / Emily J. Swindle -- Integration of the human dermal mast cell into the organotypic co-culture skin model / Jonghui Kim [and four others] -- The absolute basophil count / Elena Borzova and Clemens A. Dahinden -- Mast cell and basophil cell lines : a compendium / Egle Passante -- Detection of mast cells and basophils by immunohistochemistry / Andrew F. Walls and Cornelia Amalinei -- Measuring histamine and cytokine release from basophils and mast cells / Bettina M. Jensen, Sidsel Falkencrone, and Per S. Skov -- Flow cytometric allergy diagnosis : basophil activation techniques / Chris H. Bridts [and five others] -- Microscopy assays for evaluation of mast cell migration and chemotaxis / Monika Bambousková [and three others] -- Use of humanized rat basophil leukemia (RBL) reporter systems for detection of allergen-specific IgE sensitization in human serum / Daniel Wan [and four others] -- Gene silencing approaches in mast cells and primary human basophils / Vadim V. Sumbayev and Bernhard F. Gibbs -- Basophil stimulation and signaling pathways / Edward F. Knol and Bernhard F. Gibbs -- Identification and immunophenotypic characterization of normal and pathological mast cells / José Mário Morgado [and three others] -- Identification of murine basophils by flow cytometry and histology / Christian Schwartz and David Voehringer -- Mast cell-mediated reactions in vivo / Vladimir Andrey Giménez-Rivera , Martin Metz, and Frank Siebenhaar.

Preface -- A History of the Study of Echolocation -- Phylogeny, Genes, and Hearing -- Implications for the Evolution of Echolocation in Bats -- Ultrasound Production, Emission, and Reception -- To Scream or to Listen? Prey Detection and Discrimination in Animal-Eating Bats -- Roles of Acoustic Social Communication in the Lives of Bats -- Guild Structure and Niche Differentiation in Echolocating Bats -- Neural Coding of Signal Duration and Complex Acoustic Objects -- The Neural Processing of Frequency Modulations in the Auditory System of Bats -- Behavioral and Physiological Bases for Doppler Shift Compensation by Echolocating Bats -- Perceiving the World Through Echolocation and Vision -- Perspectives and Challenges for Future Research in Bat Hearing -- Index.

Overview: physical examination and history taking -- Clinical reasoning, assessment, and recording your findings -- Interviewing and the health history -- Beginning the physical examination: general survey, vital signs, and pain -- Behavior and mental status -- Skin, hair, and nails -- Head and neck -- Thorax and lungs -- Cardiovascular system -- Breasts and axillae -- Abdomen -- Peripheral vascular system -- Male genitalia and hernias -- Female genitalia -- Anus, rectum, and prostate -- Musculoskeletal system -- Nervous system -- Assessing children: infancy through adolescence -- Pregnant woman -- Older adult.

Bates' Guide to Physical Examination and History Taking is designed for medical, physician assistant, nurse practitioner, and other students who are learning to interview patients, perform their physical examination, and apply clinical reasoning and shared decision making to their assessment and plan, based on a sound understanding of clinical evidence. The twelfth edition has many new features to facilitate student learning. As with previous editions, these changes spring from three sources: the feedback and reviews of students, teachers, and faculty; our commitment to making the book easier to read and more efficient to use; and the abundant new evidence that supports the techniques of examination, interviewing, and health promotion. Throughout the twelfth edition, we emphasize common or important problems rather than the rare or esoteric, though at times we include unusual findings that are classic or life threatening. We encourage students to study the strong evidence base that informs each chapter and to carefully review the clinical guidelines and citations from the health care literature. -- Provided by publisher.

"The thirteenth edition of Bates' Guide to Physical Examination and History Taking is your comprehensive guide to learning to effectively conduct the health interview and physical examination. This section introduces you to the features and learning tools that will lead to successful health assessments, regional examinations, and working with special patient populations. At the start of every chapter, you will see a list of additional learning resources that complement the book in order to build your knowledge and confidence in history taking and examination. The Bates' Visual Guide to Physical Examination offers over more than 8 hours of video content and delivers head-to-toe and systems-based physical examination techniques. When used alongside the book, you have a complete learning solution for preparedness for the boards and patient encounters"-- Provided by publisher.

"Bates' Pocket Guide to Physical Examination and History Taking, ninth edition, is a concise, portable text, with new chapters that expand its scope to include all aspects of clinical skills training and education"-- Provided by publisher.

This book gathers contributions by 16 international authors on the phenomenon bats, shedding some light on their morphology, the feeding behaviors (insects, fruits, blood) of different groups, their potential and confirmed transmissions of agents of diseases, their endo- and ectoparasites, as well as countless myths surrounding their lifestyle (e.g. vampirism, chupacabras, batman etc.). Bats have been known in different cultures for several thousand centuries, however their nocturnal activities have made them mysterious and led to many legends and myths, while proven facts remained scarce. Even today, our knowledge of bats remains limited compared to other groups in the animal kingdom. Also, their famous ability to avoid collisions with obstacles during their nightly flights with the help of a sophisticated and unique system using ultrasound waves (which are transmitted and received) is as poorly studied as birds finding their way from continent to continent. In recent times, where globalization transports millions of people and goods from one end of the earth to the other, there are increased risks posed by agents of diseases, as a result of which bats have received increasing attention as potential vectors. These suppositions are based on their proven transmission of viruses such as rabies.

I : Introduction -- Bat immunology -- II : Viral infections of bats -- Rabies virus and other bat rhabdoviruses -- Henipaviruses and other paramyxoviruses of bats -- Filoviruses and bats -- Bats and coronaviruses -- Other RNA viruses and bats -- Baltimore class I and class II DNA viruses of bats -- Reverse-transcribing bat viruses and large-scale bat virome studies -- III : Bacterial infections of bats -- Arthropod-borne bacterial infections of bats -- Other bacteria and bats -- IV : Protist infections of bats -- Apicomplexans and bats -- Kinetoplastids and bats -- V : Fungal infections of bats -- White-nose syndrome and bats -- Histoplasma capsulatum and other fungi and bats -- VI : Zoonotic disease transmission and bats -- Zoonotic transmission of disease by bats and other animals.

"A rock star academic explores the final frontier of personal privacy: your mind. Imagine a world where your brain can be interrogated to learn your political beliefs, thought crimes are punishable by law, and your own feelings can be used against you. Where perfumers create customized fragrances to perfectly suit your emotions, and social media titans bypass your conscious mind to hook you to their products. A world where people who suffer from epilepsy receive alerts moments before a seizure, and the average person can peer into their own mind to eliminate painful memories or cure addictions. Neuroscience has already made all of the above possible today, and neurotechnology will soon become the "universal controller" for all of our interactions with technology. This can benefit humanity immensely, but without safeguards, it can severely threaten our fundamental human rights to privacy, freedom of thought, and self-determination. Companies, governments, and militaries are all in: from contemplative neuroscience to consumer-based EEG technology, there have never been more ways to hack and track our brains. But access is just the beginning. Our brains can be changed with performance-boosting drugs, electrical stimulation, and even surgical interventions. Soon neuro-cinema, neuro-monitoring, and even cognitive warfare will be commonplace--the brain is the next battleground for humanity. The Battle for Your Brain by Nita A. Farahany dives deeply into the promises and perils of the coming dawn of brain access and alteration. Written by one of the world's foremost experts on neuroscience as it intersects with law and ethics, this highly original book offers a pathway forward to navigate the complex ethical dilemmas that neurotechnology presents, which will fundamentally impact our freedom to understand, shape, and define ourselves"-- Provided by publisher.

Executive summary -- Overview and methods -- A human rights framework -- Prenatal care -- Relationship with maternal health care providers -- Home, hospital, or birth center? -- Labor, birthing and delivery -- The first six weeks -- Recommendations.

Section 1: An introduction to athletic evaluation. The basic foot and ankle physical exam -- Section 2: Sport syndromes. Impingement syndromes of the ankle -- Stress fractures: their causes and principles of treatment -- Medical and metabolic considerations in athletes with stress fractures -- Problematic stress fractures of the foot and ankle -- Ankle and midfoot fractures and dislocations -- Midfoot fractures and dislocations -- Rupture of the anterior tibial and peroneal tendons -- Achilles tendon disorders including tendinopathies and ruptures -- Posterior tibialis tendon injury in the athlete -- Functional nerve disorders and plantar heel pain -- Dermatologic, infectious, and nail disorders -- Section 3: Anatomic disorders in sports. Nonsurgical treatment of acute and chronic ankle instability -- Ankle sprains, ankle instability, and syndesmosis injuries -- Osteochondral lesions of the ankle and occult fractures of the foot and ankle -- Disorders of the subtalar joint, including subtalar sprains and tarsal coalitions -- Diagnostic and operative ankle and subtalar joint arthroscopy -- Foot and ankle endoscopy -- Lesser toe disorders -- Great-toe disorders -- Bunions in the elite athlete: the philosophy and principles -- Chronic leg pain -- Section 4: Unique and exceptional problems in sports. Foot and ankle injuries in dancers -- The military athlete -- Pediatric problems and rehabilitation geared to the young athlete -- Unique considerations for foot and ankle injuries in the female athlete -- Section 5: New advances and augmentations in the foot and ankle. Orthobiologics in foot and ankle applications -- Section 6: rehabilitation and recovery: principles, collaboration, and teamwork -- Rehabilitation of specific foot and ankle issues -- Principles of rehabilitation for the foot and ankle -- The team in the care of the athlete

Over the decades, research has demonstrated that in categories of life deemed to be important, beautiful people achieve more desirable outcomes, are judged more favorably, and receive preferential treatment. An understanding of the historical aspects, science, and implications of what the human mind finds aesthetically pleasing is quintessential for dermatologists, plastic surgeons, and others who practice aesthetic medicine as the importance of beauty in today?s society is what brings patients into clinics. While an element of dissatisfaction with one?s appearance is commonplace, clinicians should remain vigilant for individuals who seek cosmetic procedures to quell excessive body image concerns that are out of proportion to objective physical findings. Body dysmorphic disorder (BDD) is a disorder of self-perception; it is the impairing preoccupation with a nonexistent or minimal flaw in appearance. According to recent statistics, BDD occurs in 0.7?2.4% of the general population; however, multiple studies have suggested an incidence of 6?16% in patients seeking aesthetic medical treatments. Moreover, a vast majority will at some point seek dermatologic treatment and cosmetic surgery. Such patients are unlikely to be satisfied with corrective procedures, and only 15% of dermatologists surveyed thought that they could successfully treat BDD. Therefore, Beauty and Body Dysmor phic Disorder aims to assist dermatologists, plastic surgeons, and other aesthetic providers in recognizing key characteristics as well as providing treatment strategies to help in caring for those with BDD.

"An intimate, powerful, and inspiring memoir by the former First Lady of the United States. When she was a little girl, Michelle Robinson's world was the South Side of Chicago, where she and her brother, Craig, shared a bedroom in their family's upstairs apartment and played catch in the park, and where her parents, Fraser and Marian Robinson, raised her to be outspoken and unafraid. But life soon took her much further afield, from the halls of Princeton, where she learned for the first time what if felt like to be the only black woman in a room, to the glassy office tower where she worked as a high-powered corporate lawyer--and where, one summer morning, a law student named Barack Obama appeared in her office and upended all her carefully made plans. Here, for the first time, Michelle Obama describes the early years of her marriage as she struggles to balance her work and family with her husband's fast-moving political career. She takes us inside their private debate over whether he should make a run for the presidency and her subsequent role as a popular but oft-criticized figure during his campaign. Narrating with grace, good humor, and uncommon candor, she provides a vivid, behind-the-scenes account of her family's history-making launch into the global limelight as well as their life inside the White House over eight momentous years--as she comes to know her country and her country comes to know her. [This book] takes us through modest Iowa kitchens and ballrooms at Buckingham Palace, through moments of heart-stopping grief and profound resilience, bringing us deep into the soul of a singular, groundbreaking figure in history as she strives to live authentically, marshaling her personal strength and voice in service of a set of higher ideals. In telling her story with honesty and boldness, she issues a challenge to the rest of us: Who are we and who do we want to become?"--Publisher's description.

"Becoming Disabled attempts to forge a new view of the world, one that understands disability as a valuable human variation, embraces interdependency, recognizes the disabling impact of existing ideologies and institutions, and works toward the creation of a society that fully includes, supports, and celebrates all forms of human diversity"-- Provided by publisher.

"Becoming Metric-Wise: A Bibliometric Guide for Researchers aims to inform researchers about metrics so that they become aware of the evaluative techniques being applied to their scientific output. Understanding these concepts will help them during their funding initiatives, and in hiring and tenure. The book not only describes what indicators do (or are designed to do, which is not always the same thing), but also gives precise mathematical formulae so that indicators can be properly understood and evaluated. Metrics have become a critical issue in science, with widespread international discussion taking place on the subject across scientific journals and organizations. As researchers should know the publication-citation context, the mathematical formulae of indicators being used by evaluating committees and their consequences, and how such indicators might be misused, this book provides an ideal tome on the topic. Provides researchers with a detailed understanding of bibliometric indicators and their applications. Empowers researchers looking to understand the indicators relevant to their work and careers. Presents an informed and rounded picture of bibliometrics, including the strengths and shortcomings of particular indicators. Supplies the mathematics behind bibliometric indicators so they can be properly understood. Written by authors with longstanding expertise who are considered global leaders in the field of bibliometrics"-- Provided by publisher.

"Bestselling writer and psychotherapist Irvin D. Yalom puts himself on the couch in a lapidary memoir Irvin D. Yalom has made a career of investigating the lives of others. In this profound memoir, he turns his writing and his therapeutic eye on himself. He opens his story with a nightmare: He is twelve, and is riding his bike past the home of an acne-scarred girl. Like every morning, he calls out, hoping to befriend her, "Hello Measles!" But in his dream, the girl's father makes Yalom understand that his daily greeting had hurt her. For Yalom, this was the birth of empathy; he would not forget the lesson. As Becoming Myself unfolds, we see the birth of the insightful thinker whose books have been a beacon to so many. This is not simply a man's life story, Yalom's reflections on his life and development are an invitation for us to reflect on the origins of our own selves and the meanings of our lives"-- Provided by publisher.

This book describes bedside pain management interventions for basic clinical situations commonly encountered during the inpatient care. It aims to provide clinicians with real-world practical information, including patient selection, required equipment, and procedure guidance, that will optimize patient management. Each chapter addresses a particular procedure or a set of procedures, with specialties selected according to the subject matter. Physicians of any specialty practicing in hospital settings, residents, fellows in training, medical students, physician assistants, nurse practitioners, nurses, psychology, chiropractors, physical therapy and integrative medicine specialists will find this text to be comprehensive and practical.

"Covering the essentials of normal and abnormal human development for students in a variety of health science disciplines, Before We Are Born: Essentials of Embryology and Birth Defects, 10th Edition, reflects new research findings and current clinical practice through concise text and abundant illustrations. This edition has been fully updated by the world's foremost embryologists and is based on the popular text, The Developing Human, written by the same author team. It provides an easily accessible understanding of all of the latest advances in embryology, including normal and abnormal embryogenesis, causes of birth defects, and the role of genes in human development."--Provided by publisher.

An introduction to cancer cell biology & genetics -- Introducing targeted cancer treatments -- Treatments that block proteins involved in cell communication -- Drugs that target : angiogenesis, fusion proteins, PARP, hedgehog signalling and CDKs -- Immunotherapy treatments -- Progress in developing targeted treatments for common solid cancers -- Targeted treatments for haematological cancer.

The blood film and count -- Assessing red cells -- Assessing white cells and platelets -- Haematological findings in health and disease -- Emergency morphology -- Self-assessment.

Why do we do the things we do? Stanford professor Robert Sapolsky attempts to answer that question as fully as possible, looking at it from every angle. Sapolsky starts by examining the factors that bear on a person's reaction in the precise moment a behavior occurs, and then hops back in time from there, in stages, ultimately ending up at the deep history of our species and its evolutionary legacy.-- Provided by publisher.

Intended for use by clinicians to understand and organize conditions that may not be clearly delineated in DSM-5, this guide features twelves case studies together with an overview of behavioral addictions from neurobiological, theoretical, clinical, and forensic perspectives.--Adapted from Preface.

Overview of dementia -- Comprehensive management of dementia -- Introduction to behavioral and psychological symptoms of dementia -- Assessment of behavioral and psychological symptoms of dementia -- Management of behavioral and psychological symptoms of dementia -- Management of other threats to safety -- Ethical and legal considerations.

A comprehensive, state-of-the-art contribution to a field that is rapidly developing, The Behavioral Consequences of Stroke provides a broad overview of the cognitive and neurobehavioral effects of stroke. As attention to paralysis and the more obvious physical disabilities stroke patients incur expands, greater attention is being paid today to the cognitive and neurobehavioral complications that impact stroke morbidity and even functional neurological recovery in patients. Written by an international panel of experts and edited by a neurosurgeon and by a cognitive neuroscientist, this unique title addresses the full range of issues relevant to the field, including epidemiology, general treatment, sensorimotor control after stroke, post-stroke aphasia, memory loss after stroke, post-stroke depression, the role of imaging after a stroke, and an update on some stroke clinical trials, to name just some of the areas covered. Illuminative and an influential addition to the literature, The Behavioral Consequences of Stroke will serve as an invaluable resource for neurologists, neurosurgeons, physiatrists and other physicians, as well as physical, speech and occupational therapists, nurses, psychologists, and other professionals.

This book covers central aspects of behavioral ecology, including sexual selection, social and genetic mating systems, cooperative breeding, brood parasitism, brood reduction, migration, personalities, and communication. Over the past several years, Neotropical bird species from temperate to tropical latitudes of South America have been extensively studied yielding valuable insights into the evolutionary mechanisms that drive their behavioral traits. International experts provide a general overview of main behavioral aspects, and present the main findings of their work, including experimental approaches to testing the most accepted behavioral theory in their model systems. They propose new theoretical frameworks and future research directions. The book provides a comprehensive and updated guide for all researchers, students, and professionals whose work involves the study and management of birds across the Neotropical region.

This open access book summarizes the multi-disciplinary results of one of China's main primatological research projects on the endemic Tibetan macaque (Macaca thibetana), which had continued for over 30 years, but which had never been reported on systematically. Dedicated to this exceptional Old World monkey, this book makes the work of Chinese primatologists on the social behavior, cooperation, culture, cognition, group dynamics, and emerging technologies in primate research accessible to the international scientific community. One of the most impressive Asian monkeys, and the largest member of its genus, the Tibetan macaque deserves to be better known. This volume goes a long way towards bringing this species into the spotlight with many excellent behavioral analyses from the field.- Frans de Waal, Professor of Psychology, Emory University, USA. Macaques matter. To understand primate patterns and trends, and to gain important insight into humanity, we need to augment and expand our engagement with the most successful and widespread primate genus aside from Homo. This volume focuses on the Tibetan macaque, a fascinating species with much to tell us about social behavior, physiology, complexity and the macaque knack for interfacing with humans. This book is doubly important for primatology in that beyond containing core information on this macaque species, it also reflects an effective integrated collaboration between Chinese scholars and a range of international colleagues--exactly the type of collaborative engagement primatology needs. This volume is a critical contribution to a global primatology. - Agustín Fuentes, Professor of Anthropology, University of Notre Dame, USA. I have many fond memories of my association with Mt. Huangshan research beginning in 1983, when together with Professor Qishan Wang we established this site. It is such a beautiful place and I miss it. It is gratifying to see how far research has progressed since we began work there, becomi ng more internationalized and very much a collaborative endeavor under the long-term direction of Professor Jin-Hua Li and colleagues. This book highlights the increased interest in this species, representing a variety of disciplines ranging from macro aspects of behavior, cognition and sociality, to micro aspects of microbes, parasites and disease, authored by a group of renowned Chinese and international primatologists. I applaud their efforts and expect more interesting work to come from this site in the years ahead.- Kazuo Wada, Professor Emeritus, Kyoto University, Japan.

This fully updated second edition focuses on mental illness, both globally and in terms of specific mental-health-related visits encountered in emergency department settings, and provides practical input from physicians experienced with adult emergency psychiatric patients. It covers the pre-hospital setting and advising on evidence-based practice; from collaborating with psychiatric colleagues to establishing a psychiatric service in your emergency department. Potential dilemmas when treating pregnant, geriatric or homeless patients with mental illness are discussed in detail, along with the more challenging behavioral diagnoses such as substance abuse, factitious and personality disorders, delirium, dementia, and PTSD. The new edition of Behavioral Emergencies for Healthcare Providers will be an invaluable resource for psychiatrists, psychologists, psychiatric and emergency department nurses, trainee and experienced emergency physicians, and other mental health workers.

Behavioral Medicine delivers real-world coverage of behavioral and interactional issues that occur between provider and patient in everyday clinical practice.

"This fifth edition of Behavioral Medicine: A Guide for Clinical Practice features important revisions of chapters from the previous editions to reflect advances in pharmacotherapy and evidence on the relationship between psychosocial factors and disease"-- Provided by publisher.

Part I. Mechanistic Aspects Underlying Alcoholism -- Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit Disorder / George F. Koob -- Synaptic Effects Induced by Alcohol / David M. Lovinger and Marisa Roberto -- Signaling Pathways Mediating Alcohol Effects / Dorit Ron and Robert O. Messing -- Neurocircuitry Involved in the Development of Alcohol Addiction: The Dopamine System and its Access Points / Bo Söderpalm and Mia Ericson -- What is in that Drink: The Biological Actions of Ethanol, Acetaldehyde, and Salsolinol / Gerald A. Deehan Jr., Mark S. Brodie and Zachary A. Rodd -- Part II. Genetics -- Modeling the Diagnostic Criteria for Alcohol Dependence with Genetic Animal Models / John C. Crabbe, Kenneth S. Kendler and Robert J. Hitzemann -- Non-Human Primate Models of Alcohol-Related Phenotypes: The Influence of Genetic and Environmental Factors / Christina S. Barr -- Genetically Selected Alcohol Preferring Rats to Model Human -- Alcoholism / Roberto Ciccocioppo -- Advanced Transgenic Approaches to Understand Alcohol-Related Phenotypes in Animals / Ainhoa Bilbao -- Part III. Clinical Phenotypes and Preclinical Models Thereof Modeling Alcohol Self-Administration in the Human Laboratory / Ulrich S. Zimmermann, Sean O'Connor and Vijay A. Ramchandani -- Animal Models of Excessive Alcohol Consumption in Rodents / Howard C. Becker -- Modeling Relapse Situations in the Human Laboratory / Rajita Sinha -- Modeling Relapse in Animals / Rémi Martin-Fardon and Friedbert Weiss -- Invertebrate Models of Alcoholism / Henrike Scholz and Julie A. Mustard -- Part IV. Novel Insights from Brain Imaging The Dopamine System in Mediating Alcohol Effects in Humans / K. Charlet, A. Beck and A. Heinz -- Stimulant and Sedative Effects of Alcohol / Reuben A. Hendler, Vijay A. Ramchandani, Jodi Gilman and Daniel W. Hommer -- Chronic Alcohol Consumption, Abstinence and Relapse: Brain Proton Magnetic Resonance Spectroscopy Studies in Animals and Humans / Dieter J. Meyerhoff, Timothy C. Durazzo and Gabriele Ende -- Part V. Translational Aspects and Medication Development -- Translational Approaches to Medication Development / Selena Bartlett and Markus Heilig -- New Pharmacological Treatment Strategies for Relapse Prevention / Rainer Spanagel and Valentina Vengeliene -- The Challenge of Studying Parallel Behaviors in Humans and Animal Models / David N. Stephens, Hans S. Crombag and Theodora Duka -- A Translational Approach to Novel Medication Development for Protracted Abstinence / Barbara J. Mason and Amanda E. Higley -- New Approaches to Addiction Treatment Based on Learning and Memory / Falk Kiefer and Christina Dinter -- Adolescent Substance Misuse: Neurobiology and Evidence-Based Interventions / Nicola C. Newton, Maeve O'Leary-Barrett and Patricia J. Conrod -- Deep Brain Stimulation as a Therapy for Alcohol Addiction / Thomas F. Münte, Hans-Jochen Heinze and Veerle Visser-Vandewalle.

This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. It is essential reading for scientists, clinicians and students in need of a comprehensive review of behavioral readouts for the preclinical assessment of chronic pain and analgesic drug efficacy, or those with a general interest in behavioral neuroscience. At the core of this volume are emerging details of the physiology, pharmacology, and psychology of previously neglected types of chronic pain. These types include chronic post-operative pain in humans as well as animal behavioral assays that model the chronic pain of multiple sclerosis, post-herpetic neuralgia, painful diabetic neuropathy, visceral pain, latent central sensitization, and chronic muscle pain. Also emphasized are the complex bidirectional comorbidities between chronic pain and drug dependence, cognitive deficit, stress, anxiety, depression, social interaction, and prior injury history. The novel and exciting ideas introduced within this book, such as endogenous opioid dependence after tissue injury, generate real hope that effective treatment strategies for chronic pain will emerge in the near future.

The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.

Clinical Aspects of Huntington's Disease -- The Neuropathology of Huntington's Disease -- Neurobiology of Huntington's Disease -- Mouse Models of Huntington's Disease -- Transgenic Rat Models of Huntington's Disease -- Large Animal Models of Huntington's Disease -- Therapeutic Strategies for Huntington's Disease -- Clinical and Pathological Features of Parkinson's Disease -- Symptomatic Models of Parkinson?s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates -- Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration? -- Viral Vector-Based Models of Parkinson's Disease -- Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits -- Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents -- Models of Multiple System Atrophy.

Stress is such an over-used word that it is at time difficult to define its core features. When is an environment stressful? What does a stressful environment do to the brain and to the body? What are the biological mechanisms by which a stressor affects us? How does stress contributes to the onset and the progression of mental disorders? How do the effects of stress change over the life-time of an individual? These are just some of the overarching questions addressed by this book, thanks to the contribution of some of the world leading experts on the neurobiology of stress at the pre-clinical and clinical levels. Topics include current advances on the neurobiology of stress on various neurobiological systems such as immune, hypothalamic-pituitary-adrenal (HPA) axis, neurogenesis and neuroplasticity, neurotransmitter (glutamate, noradrenaline, dopamine, serotonin and endocannabinoid), neuropeptides, cognition and emotional processing as well as in utero and early postnatal effects. The clinical chapters deal with the relationship of stress and mental disorders such as depression, posttraumatic stress disorder (PTSD), anxiety disorders, schizophrenia, bipolar disorder, substance abuse and addiction, dementia and age-related cognitive decline as well as resilience to stress. Thus, this book brings together some of the most updated and authoritative views on the effects of stress of brain and behavior.

Section 1. Neuroendocrinology of sexual behavior -- section 2. Neuroendocrinology of maternal behavior and brain development -- section 3. Neuroendocrine insights toward development of therapeutic agents -- section 4. Epilogue.

This book provides a unique overview on the most recent developments in initially diverse areas of behavioral genomic research that now start to intertwine to provide more detailed insights into the complex nature of behavior in health and disease. It focuses on our current understanding of genetic and epigenetic mechanisms of brain function and how they contribute to the complex formation of behavioral traits and psychiatric disorders. Readers experience diverse perspectives of the contributing authors starting from the genetic viewpoint and the effort to establish functional connection between genetic variants and behavioral phenotypes. Particular attention is given to the broad spectrum of epigenetic mechanisms and behavior. The chapter 'Role of MicoRNAs in Anxiety and Anxiety-Related Disorders', DOI 10.1007/7854_2019_109, available open access under a CC BY 4.0 license at link.springer.com.

Part 1 -- THE NEUROBIOLOGY OF COMPONENTS OF MOTIVATIONAL DRIVE -- Regulation of the Motivation to Eat -- Sexual Motivation Opposed by the Influences of Stress -- Motivational Forces Driving Social Behaviours -- The Roles of Wanting and Liking in Motivating Behaviour, Including Gambling, Food and Drug Addiction. Circadian Regulation of Motivated Behaviour -- How Negative Forces Influence Motivations Part 2 -- NEURAL MEASURES AND CORRELATES OF MOTIVATION SIGNALS AND COMPUTATIONS -- Neural Computations of Postive and Negative Reward Value -- The Dopaminergic Regulation of Motivated Behaviour -- Neural Modulators other than Dopamine that Regulate Motivated Behaviours -- Neural Correlates of Motivation Signals in Humans -- Motivational Forces in Decision Making Processes -- Part 3 -- APATHY AND PATHOLOGICAL DEFICITS IN MOTIVATION -- The Identification of Phenotypes and Biomarkers in Depression -- Defining Motivation Deficits in Schizophrenia and Relating them to Clinical Symptoms -- Dissecting the Behavioural components of deficits in motivation in Patients with Schizophrenia -- How Deficits in Motivation are Similar and Different in Depression and Schizophrenia -- Modeling Motivation Deficits in Rodents -- Part 4 -- ADDICTION AND THE APTHOLOGICAL MISDIRECTION OF MOTIVATED BEHAVIOUR -- Motivation in Overdrive: Substance Abuse Disorder -- Insight into Gambling motivation from Animal Models -- Part 5 -- DEVELOPMENTS IN TREATMENTS FOR MOTIVATION PATHOLOGIES -- The Role of Motivation in Schizophrenia Cognitive Remediation -- The Impact of Regulating Focus on Motivated Behaviour -- Insights into Gambling Motivation from Animal Models -- Exploring Pharmacological Agents in Animal Models.

The beginning of life: pregnancy through preschool -- School age, adolescence, special issues of development, and adulthood -- Aging, death, and bereavement -- Genetics, anatomy, and biochemistry of behavior -- Biological assessment of patients with psychiatric symptoms -- Psychoanalytic theory and defense mechanisms -- Learning theory -- Clinical assessment of patients with behavioral symptoms -- Substance-related disorders -- Normal sleep and sleep disorders -- Schizophrenia spectrum and other psychotic disorders -- Depressive disorders and bipolar and related disorders -- Anxiety disorders, somatic disorders, and related conditions -- Neurocognitive, personality, dissociative, and eating disorders -- Psychiatric disorders in children -- Biologic therapies: psychopharmacology -- Psychological therapies -- The family, culture, and illness -- Sexuality -- Aggression and abuse -- The physician-patient relationship -- Psychosomatic medicine -- Legal and ethical issues in medicine -- Health care in the United States -- Medical epidemiology -- Statistical analyses.

"Offering current coverage of behavioral science, psychiatry, epidemiology, and related topics, BRS Behavioral Science, Eighth Edition, prepares students to rapidly recall key information on the mind-body relationship and confidently apply that knowledge on exams and in practice. The popular BRS format presents essential information in a succinct, streamlined approach preferred by today's busy students, accompanied by hundreds of USMLE-style review questions with detailed answers and explanations to help strengthen students' exam readiness"-- Provided by publisher.

"This is a practical guide to designing and evaluating behaviour change interventions and policies. It is based on the Behaviour Change Wheel, a synthesis of 19 behaviour change frameworks that draw on a wide range of disciplines and approaches. The guide is for policy makers, practitioners, intervention designers and researchers and introduces a systematic, theory-based method, key concepts and practical tasks"--Publisher website.

This book, besides reviewing basic and clinical aspects of Behėt's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behėt's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behėt's disease. Behėt's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behėt's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.

1. The Numbers of Behçet: A Rare Disease? / Agata Polizzi and Domenica Taruscio -- 2. From Hippocrates to Hulusi Behçet: What History / Donatella Lippi -- 3. Epidemiology of Behçet Syndrome / Olga Addimanda, Giulia Pazzola, Nicolò Pipitone and Carlo Salvarani -- 4. Behçet's Syndrome According to Classical and Population Genetics / Akira Meguro, Nobuhisa Mizuki, Ahmet Gül, Nobuyoshi Kitaichi and Shigeaki Ohno -- 5. Infections, Autoimmunity, and Behçet's Syndrome: What Liaison? / Mario Milco D'Elios, Marisa Benagiano, Amedeo Amedei and Giacomo Emmi -- 6. Pathogenesis of Behçet Syndrome / Giacomo Emmi, Danilo Squatrito, Elena Silvestri, Alessia Grassi and Lorenzo Emmi -- 7. Mucocutaneous Involvement in Behçet's Syndrome / Umit Tursen -- 8. Neurological and Neuropsychological Manifestation in Behçet's Syndrome / Shunsei Hirohata -- 9. Ocular Involvement and Behçet Disease / Lorenzo Vannozzi, Ugo Menchini and Massimo Accorinti -- 10. Articular and Muscular Manifestations in Behçet's Disease / Anne-Claire Desbois, Betrand Wechsler and David Saadoun -- 11. Cardiovascular Issues: Aneurysms and Pseudoaneurysms, Thrombosis, Atherosclerosis, and Cardiac Involvement / Elena Silvestri, Caterina Cenci, Chiara Della Bella, Anna Maria Cameli and Domenico Prisco -- 12. Intestinal Behçet Disease / Cristina Cenci and Monica Milla -- 13. Audio Vestibular Involvement in Behçet's Disease / Paolo Vannucchi and Rudi Pecci -- 14. Behçet's Syndrome and Gynecological Manifestation in Reproductive Age and Pregnancy / Maria Elisabetta Coccia and Tommaso Capezzuoli -- 15. Pediatric Onset of Behçet Syndrome / Ezgi Deniz Batu, Rolando Cimaz and Seza Özen -- 16. Behçet's Disease. Differential Diagnosis / Maria Grazia Sabbadini and Stefano Franchini -- 17. Classification and Diagnosis Criteria for Behçet's Disease / Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Farhad Shahram, Cheyda Chams-Davatchi, Hormoz Shams and Abdolhadi Nadji -- 18. Prognosis and Disease Activity / Rosaria Talarico, Anna d'Ascanio, Rossella Neri, Chiara Baldini, Marta Mosca and Stefano Bombardieri -- 19. Old and New Treatment for Behçet's Disease / Fabrizio Cantini and Gerardo Di Scala -- 20. Surgical Treatment of Angio-Behçet / Stefano Camparini and Genadi Genadiev.

The expanded second edition of this important work provides an up-to-date and comprehensive overview of Behçet syndrome. New and updated chapters focus on recent advances in the areas of pathogenesis, the microbiome, genetics and epigenetics, clustering of symptoms, disease assessment and new treatment options. The book examines how these developments have changed the way physicians approach diagnosis, treatment, and management of Behçet patients. It also analyzes the wide variety of clinical manifestations of the disease including mucocutaneous lesions, intraocular inflammation, central nervous system involvement, deep vein thrombosis and other forms of major vascular disease. Building on the success of its predecessor, the Second Edition of Behçet Syndrome is an invaluable resource for physicians, residents, fellows, and graduate students in rheumatology, dermatology, ophthalmology, neurology, gastroenterology, and internal medicine.

In the fall of 2007, Jende Jonga, a Cameroonian immigrant living in Harlem, lands a job as a chauffeur for Clark Edwards, a senior executive at Lehman Brothers. Their situation only improves when Jende's wife Neni is hired as household help. But in the course of their work, Jende and Neni begin to witness infidelities, skirmishes, and family secrets. Then, with the 2008 collapse of Lehman Brothers, a tragedy changes all four lives forever, and the Jongas must decide whether to continue fighting to stay in a recession-ravaged America or give up and return home to Cameroon.

This book builds a research-grounded, theoretical foundation for evidence based library and information practice and illustrates how librarians can incorporate the principles to make more informed decisions in the workplace. The book takes an open and encompassing approach to exploring evidence based library and information practice (EBLIP) and the ways it can improve the practice of librarianship. Bringing together recent theory, research, and case studies, the book provides librarians with a new reference point for how they can use and create evidence within their practice, in order to better meet the needs of their communities. Being Evidence Based in Library and Information Practice is divided into two parts; in the first part the editors explore the background to EBLIP and put forward a new model for its application in the workplace which encompasses 5 elements: Articulate, Assemble, Assess, Agree, Adapt. In the second part, contributors from academic, public, health, school and special libraries from around the world provide an overview of EBLIP developments in their sector and offer examples of successful implementation. The book will be essential reading for library and information professionals from all sectors who want to make more informed decisions and better meet the needs of their users. The book will also be of interest to students of library and information studies and researchers.

Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families of the terminally ill.

This book provides a clear framework for conducting participatory research with children and young people supported with practical examples from international research studies. Our aim is to encourage more participatory research with children and young people on all matters that affect their lives. This book illustrates innovative ways of being participatory and sheds new light on involvement strategies that play to children's and young people's competencies. Participatory research is based on the recognition of children and young people as active contributors rather than objects of research. Participatory researchers support and value the voices of children and young people in all matters that concern them. Core to participatory research practice is a strengths-based approach that aims to promote the active engagement of children and young people in all stages of research, from inception to implementation. Engagement of children and young people requires the use of creative, participatory methods, tools and involvement strategies to reveal children's competencies. This book shares knowledge about creative participatory techniques that can enable and promote children's ways of expressing their views and experiences. The book provides guidance on appropriate techniques that reduce the power differential in the adult-child relationship and which optimise children's abilities to participate in research. This book is targeted at researchers, academics, practitioners who need guidance on what tools are available, how the tools can be used, advantages and challenges, and how best to involve children in all stages of a research project. It will provide several examples of how children can have an active participatory role in research. There is increasing interest in involving children as co-researchers but little guidance on how this can be done. This book fills a gap in the current books by addressing all of these issues outlined above and by providing worked examples from leading researchers and academics. It will have wide appeal across a range of different disciplines.

Contents -- 1. Faltensystem und Verschlusseinrichtung der Vagina, von F. Orsós.

This book provides a straightforward and easy-to-understand overview of beneficial plant-bacterial interactions. It features a wealth of unique illustrations to clarify the text, and each chapter includes study questions that highlight the important points, as well as references to key experiments. Since the publication of the first edition of Beneficial Plant-Bacterial Interactions, in 2015, there has been an abundance of new discoveries in this area, and in recent years, scientists around the globe have begun to develop a relatively detailed understanding of many of the mechanisms used by bacteria that facilitate plant growth and development. This knowledge is gradually becoming an integral component of modern agricultural practice, with more and more plant growth-promoting bacterial strains being commercialized and used successfully in countries throughout the world. In addition, as the worlds population continues to grow, the pressure for increased food production will intensify, while at the same time, environmental concerns, mean that environmentally friendly methods of food production will need to replace many traditional agricultural practices such as the use of potentially dangerous chemicals. The book, intended for students, explores the fundamentals of this new paradigm in agriculture, horticulture, and environmental cleanup.

Prologue -- Preface -- Overview -- Approaches to utilising decision-making framework -- Benefit-risk assessment of medicines by pharmaceutical companies and regulatory authorities -- Development of a universal benefit-risk framework and template -- Implementation of the benefit-risk assessment template by mature agencies -- Implementation of the benefit- risk summary template by a maturing agency: A case study -- Communicating benefit-risk decisions by US FDA, EMA, TGA and Health Canada -- Conclusions and future directions -- References.

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

This book illustrates the role of Mediterranean diet in connection with well-being and particularly its impact on health and elderly care, as well as on the mechanisms of aging. Aging is a natural process of human life. The knowledge that a healthy dietary regimen like the Mediterranean diet can effectively prevent or delay many diseases typically affecting aging people may help to better manage the aging process. From this point of view, knowledge of the numerous benefits of the Mediterranean-style diet may effectively promote better management of the burden of elderly care. As early as the 1950s, Ancel Keys pointed out the effectiveness of the Mediterranean diet in helping to control, and possibly avoid, myocardial infarction and/or cholesterol metabolism. Quite soon after the first studies were published, it became clear that the Mediterranean diet was beneficial not only in connection with cardiovascular disease but also many other diseases, from diabetes to hypertension, from cancer and thrombosis to neurodegenerative diseases, including dementia. Examining those benefits in detail, this book offers a valuable educational tool for young professionals and caregivers, as well as for students and trainees in Geriatrics and Nutrition.

Benign & Pathological Chromosomal Imbalances systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy. Shows how to define the inheritance and formation of cytogenetically visible copy number variations using cytogenetic and molecular approaches for genetic diagnostics, patient counseling, and treatment plan development. Uniquely classifies all known variants by chromosomal origin, saving time and money for researchers in reviewing benign and pathologic variants before costly molecular methods are used to investigate. Side-by-side comparison of copy number variants with their recently identified submicroscopic form, aiding technology assessment using aCGH and other techniques.

1. Surgical anatomy of anal canal and rectum -- 2. Physiology of defecation -- 3. Hemorrhoids -- 4. Anal fissure -- 5. Perianal sepsis and fistula -- 6. Pilonidal disease -- 7. Rectovaginal fistulas -- 8. Anorectal injuries -- 9. Anal incontinence -- 10. Complete rectal prolapse in adults -- 11. Pelvic floor dysfunction -- 12. Perianal dermatiology -- 13. Benign ulcers of the anorectum -- 14. Benign stricutes of anorectum -- 15. Benign tumors of the anorectum.

The normal female breast -- Overview of benign breast lesions.-Radiology of breast lesions -- Surgery of benign breast lesions.-Pathology of benign breast lesions -- Inflammatory lesions -- Cystic lesions -- Fibro-epithelial lesions -- Infiltrative pseudo-malignant lesions -- Epithelial proliferative lesions -- Columnar cell lesions -- Mucocele-like lesions -- Calcification in benign lesions -- Non-epithelial lesions -- Male breast lesions -- Risk assessment in benign breast lesions.

This book aims to review all of the literature, including landmark papers and the most current published data, in regard to the management of non-malignant foregut diseases. A number of surgeons publish and focus in malignant diseases of the esophagus, but this text emphasizes the benign ones, their problems and how to face them with the new available resources and technology. This book describes the different diagnostic tools available, as well as the different therapies for the management of gastroesophageal reflux disease (GERD) and its potential complications like Barret's or strictures, and the associated anatomical abnormalities such as hiatal hernia or short esophagus, and more. Motility disorders of the esophagus, esophageal diverticula and perforations are also discussed. Different devices and approaches can be used to treat these diseases and they are covered and explained in different chapters of the book. Written by experts in the field, Benign Esophageal Disease provides surgeons and physicians with a concise and comprehensive summary of the current state of the field and will help guide patient management.

This book provides a comprehensive overview of benign hematologic disorders in children. Divided into nine sections, the text reviews common hematologic disorders or conditions that affect children, while providing state-of-the-art information on pathophysiology, diagnosis, treatment, and management strategies. The text begins with a section on hematopoiesis, and the next section covers red blood cell disorders. The following sections provide overviews of platelet disorders, white blood cell disorders, and coagulation disorders. The sixth and seventh sections discuss neonatal hematology and bone marrow failure syndrome. The eighth section reviews supportive care, while the final section covers miscellaneous subjects including pediatric vascular anomalies and complement dysregulation syndromes. Written by experts in the field, Benign Hematologic Disorders in Children: A Clinical Guide is a valuable resource for clinicians and practitioners who treat children afflicted with these disorders.

Diagnosis of benign tumors of the liver is experiencing exponential growth, mainly owing to the diffusion of more accurate imaging techniques. This monograph opens by examining the epidemiology, histopathology, and genetics of these diseases and discussing liver physiopathology. The role of imaging techniques is described, and clear guidance provided on differential diagnosis. The full range of benign liver tumors and conditions is then systematically reviewed, including liver cysts and polycystic liver disease, Caroli disease, hemangiomas, focal nodular hyperplasia, adenomas, hepatic manifestations of systemic diseases, and focal infectious diseases. Surgical indications are accurately analyzed, with a view to assisting in the avoidance of useless interventions. Transplantation, laparoscopic resection, and robotic surgical techniques are described and illustrated, emphasizing the optimization of intra- and postoperative management in order to avoid potential complications and degeneration. In these chapters, attention is drawn to the ways in which the surgical management of benign liver tumors differs from that of malignant tumors. Information is also provided on anesthesia, blood transfusion, the role of interventional radiology in patients with benign liver tumors and fast track programs for liver surgery. This book, in handy format, will prove essential reading for all who are interested in benign liver surgery and will represent an invaluable source of knowledge for general and hepatobiliary surgeons, whether in training or practice.

This book had its beginning in 1967 when Shirley G. Driscoll and Kurt Benirschke wrote in English the volume on placental pathology for the Henke-Lubarsch, the noted German Handbook of Pathology. There seemed to be a need for wider distribution of the text and it was reprinted by Springer Verlag, New York, essentially the only book available devoted just to the human placenta. Dr. Benirschke authored 5 subsequent editions in collaboration with Peter Kaufmann, Rebecca Baergen and Graham Burton in 1990 (2nd edition), 1995 (3rd edition), 2000 (4th edition), 2006 (5th edition) and 2012 (6th edition). In the early editions, the most important material was in a larger font than the extensive review of exceptions and the discussion in the literature. Since 1967, many other shorter placenta books have been published in English, French and German. None of these have included the breadth of discussion or the voluminous references which includes details of many historic articles, not readily available. Interest in the placenta has wildly expanded over the intervening 50+ years with the vast majority of Pathologists, Obstetricians and Pediatricians recognizing its value. In addition, there are now quite a few new journals, societies and meetings devoted to the placenta in both clinical and research areas. The interest extends into areas of study well beyond the realm of anatomic pathology. The 7th edition will, of necessity, differ from the prior editions which Dr. Benirschke wrote largely himself at first, and later with the help of the above noted co-authors. It will now be an international multi-authored book with nearly 40 contributors revising one or more chapters. The explosion of new information as necessitating some reordering of chapters and adding completely new chapters including Chapters 31 and 32, "Innovations in Placental Pathology" and "Imaging in Placental Pathology." Dr. Burtons section has been extensively edited, as well. The editors gave the new authors considerable latitude in how to write the new and/or edited chapters. Many of the revised chapters retain much of Dr. Benirschkes anecdotal information as well as the voluminous references. Others are more modern in their approach. All contain substantial new references and current information. It is our hope that Benirschkes Pathology of the Human Placenta will remain as a mainstay reference in placental pathology. It aims to help readers gain a broad understanding of how placental architecture is shaped during normal development, with a view to appreciating how this may be perturbed in complications of pregnancy.

Section I General Considerations of Hospital Infections -- 1. Epidemiology of Healthcare-Associated Infections / Belinda Ostrowsky -- 2. The Healthcare Epidemiologist / Bryan P. Simmons -- 3. Hand Hygiene / Didier Pittet -- 4. Occupational Health Services / Elizabeth A. Bolyard -- 5. The Development of Infection Surveillance and Prevention Programs / Keith F. Woeltje -- 6. Surveillance of Healthcare-Associated Infections / Robert P. Gaynes -- 7. The Use of Prevalence Surveys for Healthcare-Associated Infections Surveillance / Bruno P. Coignard -- 8. Investigating Endemic and Epidemic Healthcare-Associated Infections / William R. Jarvis -- 9. Epidemiologic Methods for Investigating Infections in the Healthcare Setting / Ebbing Lautenbach -- 10. Use of Computerized Systems in Healthcare Epidemiology / Keith F. Woeltje -- 11. The Role of the Laboratory in Prevention of Healthcare-Associated Infections / Daniel J. Diekema -- 12. The Practice of Epidemiology in Community Hospitals / August J. Valenti -- 13. The Role of Professional, Governmental, and Regulatory Organizations in Infection Prevention and Control / Tammy S. Lundstrom -- 14. Antimicrobial Stewardship: Programmatic Efforts to Optimize Antimicrobial Use / William R. Jarvis -- 15. Multidrug-Resistant Organisms: Epidemiology and Control / Mary K. Hayden -- 16. Molecular Biology of Resistance: A Brief History of Resistance Mechanisms and the Discovery of Gene Transfer / Robert A. Bonomo -- 17. Economic Evaluation of Healthcare-Associated Infections and Infection-Control and Antimicrobial-Stewardship Interventions / Sara E. Cosgrove -- 18. Epidemiology and Control of Healthcare-Acquired Infections in Limited-Resource Settings / Victor D. Rosenthal -- Section II Functional Areas of Concern -- 19. The Inanimate Environment / John M. Boyce -- 20. Disinfection and Sterilization in Healthcare Facilities / David J. Weber -- 21. Foodborne Disease Prevention in Healthcare Facilities / Susan Springthorpe -- 22. Clinical Laboratory---Acquired Infections / L. Barth Reller -- 23. Dialysis-Associated Complications and Their Control / Priti R. Patel -- 24. The Intensive Care Unit, Part A: HAI Epidemiology, Risk Factors, Surveillance, Engineering and Administrative Infection Control Practices, and Impact / Stephan A. Harbarth -- 25. The Intensive Care Unit, Part B: Antibiotic Resistance and Prevention of CVC-BSIs, Catheter-Associated Urinary Tract Infections, and C. difficile / Dennis G. Maki -- 26. The Newborn Nursery and the Neonatal Intensive Care Unit / Nalini Singh -- 27. The Perioperative Suite / Sharon Giarrizzo-Wilson -- 28. Ambulatory Care Settings / Kathleen H. Petersen -- 29. Infections in Long-Term Care Facilities / Chesley L. Richards Jr. -- Section III Endemic and Epidemic Hospital Infections -- 30. Incidence and Nature of Endemic and Epidemic Healthcare-Associated Infections / William R. Jarvis -- 31. Urinary Tract Infections / Carol E. Chenoweth -- 32. Hospital-Acquired and Ventilator-Associated Pneumonia / Henri Balaguera -- 33. Nosocomial Tuberculosis / Faiz Ahmad Khan -- 34. Infectious Gastroenteritis / Benjamin A. Lopman -- 35. Central Nervous System Infections / W. Michael Scheld -- 36. Surgical Site Infections / Keith S. Kaye -- 37. Infections of Burn Wounds / Basil A. Pruitt, Jr. -- 38. Infections due to Infusion Therapy / Leonard A. Mermel -- 39. Infections of Implantable Cardiac and Vascular Devices / Raymond Y. Chinn -- 40. Infections in Skeletal Prosthesis and Allografts / Daniel P. Lew -- 41. The Importance of Infection Control in Controlling Antimicrobial-Resistant Organisms / Barry M. Farr -- 42. Healthcare-Associated Respiratory Viral Infections / Janice Lo -- 43. Preventing Transmission of Bloodborne Pathogens in the Healthcare Setting / David K. Henderson -- 44. Healthcare-Associated Fungal Infections / Benjamin J. Park -- 45. Healthcare-Associated Infections in Transplant Recipients / Kent Sepkowitz -- 46. Miscellaneous Procedure-Related Infections / Robert A. Weinstein -- 47. Public Reporting of Healthcare-Associated Infection Rates / Michael P. Stevens -- 48. Patient Safety / Moi Lin Ling.

section I. General considerations of hospital infections -- section II. Functional areas of concern -- section III. Endemic and epidemic hospital infections

Covering the entire spectrum of women's healthcare, Berek & Novak's Gynecology, 16th Edition, provides definitive information and guidance for trainees and practicing physicians. A newly streamlined design and brilliant, full-color illustrations highlight must-know content on principles of practice and initial assessment, including relevant basic science; preventive and primary care for women; and methods of diagnosis and management in general gynecology, operative gynecology, urogynecology and pelvic reconstructive surgery, early pregnancy issues, reproductive endocrinology, and gynecologic oncology. --Provided by publisher.

"This is the first "Essentials" version of Berek & Novak's Gynecology, which is now in its 16th edition. This abridged volume arrives in response to many requests for an easily portable reference that contains the key points and salient features of the full-length book"-- Provided by publisher.

v. 1. The Archaea and the deeply branching and phototrophic bacteria -- v. 2. The Proteobacteria: part A. Introductory essays; part B. The Gammaproteobacteria; part C. The Alpha-, beta-, delta-, and epsilonproteobacteria -- v. 3. The Firmicutes -- v. 4. The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes -- v. 5. The Actinobacteria.

Skull -- Hyoid bone -- Cervical vertebrae -- Thoracic vertebrae -- Lumbar vertebrae -- Sacrococcygeal vertebrae -- Scapula -- Clavicle -- Humerus -- Radius ulna carpals metacarpals and phalanges -- Ribs and sternum -- Pelvic bones -- Bones of the lower limb -- Temporomandibular joint -- Shoulder joint -- Elbow joint -- Wrist and hand joints -- Sacroiliac joints -- Hip joint -- Knee joint -- Ankle and foot joints -- Orbital muscles -- Middle ear muscles -- Facial muscles and muscles of mastication -- Anterior neck muscles -- Pharyngeal muscles -- Soft palate and tongue muscles -- Prevertebral and craniocervical junction muscles -- Laryngeal muscles -- Back muscles -- Scapulohumeral muscles -- Arm muscles -- Forearm muscles -- Hand intrinsic muscles -- Thoracic wall muscles -- Abdominal wall muscles -- Pelvic diaphragm and external anal sphincter -- Perineal muscles -- Gluteal muscles -- Thigh muscles -- Leg muscles -- Intrinsic muscles of the foot -- Internal carotid artery and anterior cerebral circulation -- Vertebrobasilar arteries -- Persistent fetal intracranial arteries -- Common carotid and cervical internal carotid arteries -- External carotid artery -- Vertebral artery -- Thoracic aorta -- Coronary arteries -- Pulmonary arteries -- Subclavian artery -- Upper limb arteries -- Abdominal aorta -- Renal arteries -- Internal iliac arteries -- Lower limb arteries -- Arteries of the spinal cord -- Diploic veins -- Dural venous sinuses -- Cerebral veins -- Emissary veins -- Veins of the neck -- Veins of the upper limb -- Intrathoracic veins -- Cardiac veins -- Pulmonary veins -- Inferior vena cava portal and hepatic venous systems -- Adrenal renal gonadal azygos hemiazygos lumbar and ascending lumbar veins -- Iliac veins -- Veins of the lower limb -- Venous drainage of the spinal cord -- Thymus -- Tonsils -- Thoracic duct chyle cistern and right lymphatic duct -- Lymphatics of the lower limb -- Forebrain -- Cerebral ventricles -- Pons medulla oblongata and cerebellum -- Subarachnoid space -- Meninges -- Spinal cord and associated structures -- Cranial nerves N-VI -- Facial nerve -- Vestibulocochlear nerve -- Glossopharyngeal nerve -- Vagus accessory and hypoglossal nerves -- Autonomic nervous system -- Spinal nerves -- Cervical plexus -- Nerves of the upper extremity -- Lumbosacral plexus -- Facial asymmetry -- Eyelids eyelashes and eyebrows -- Eye and lacrimal apparatus -- Lateral nasal wall and paranasal sinuses -- Ear -- Salivary glands and ducts -- Thyroid gland -- Parathyroid glands -- Laryngeal cartilages -- Trachea -- Lungs -- Heart -- Esophagus -- Stomach -- Gallbladder and extrahepatic bile ducts -- Liver -- Pancreas -- Spleen -- Small intestines appendix and colon -- Sigmoid colon rectum and anus -- Kidney urinary bladder and ureter -- Adrenal gland -- Male genitourinary system -- Female genital system -- Placenta and umbilical cord -- Breast.

Berkowitz's Pediatrics is the first choice of textbook reference for pediatricians, residents, and medical students! The newly revised and expanded 6th edition provides clear, practice-oriented guidance on the core knowledge in pediatrics

" Pairing necessary detail with concise readability, Berne & Levy Physiology, 8th Edition, provides a perfect balance of content to deliver an in-depth understanding of the body's dynamic processes. Long respected for its scientifically rigorous approach, this highly regarded, mid-size text offers essential physiology with integrated coverage of biophysics andkey experimental observations and examples—all designed to provide a solid scientific foundation in physiology for future scientists and clinicians. Uses a logical, organ system-based approach that clearly describes all of the mechanisms that control and regulate bodily function. Includes new clinical case examples, as well as In the Clinic and At the Molecular Level boxes that highlight practical aspects of this fundamental science. Provides key experimental observations and examples that offer a rich understanding of the body's dynamic processes. Discusses recent discoveries such as the role of lymphatics in the nervous system. Begins each chapter with a bulleted list of questions and ends with key concepts covered in that chapter. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. " -- Provided by publisher.

"Berquist's Musculoskeletal Imaging Companion is a practical quick-reference guide to the radiologic diagnosis of musculoskeletal disorders. It presents over 1500 large, clear images of common diseases, disorders, and injuries, accompanied by succinct, bulleted "key facts" about the clinical and imaging features of each condition. Chapters cover all anatomic regions and disease entities, imaging of orthopaedic appliances and prostheses, and detailed protocols for all current imaging modalities. The book demonstrates the utility of multiple modalities in specific situations and recommends the best, most cost-effective approach"--Provided by publisher.

Introduction -- Overview of Structural Interventions to Decrease Injection Drug-Use Risk -- Overview of Structural Interventions to Decrease Noncommercial Sex Risk -- Overview of Structural Interventions to Decrease Commercial Sex Risk -- Overview of Structural Interventions to Increase Voluntary Counseling and Testing (VCT) and Antiretroviral Therapy (ART) -- Conclusion.