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  • Book
    Michael R. Migden, Leon Chen, Sirunya Silapunt, editors.
    Contents:
    Chapter 6: Cryotherapy and Electrodesiccation & Curettage for Basal Cell Carcinoma Intro
    Preface
    Contents
    Contributors
    Editor Biographies
    Chapter 1: Epidemiology and Risk Factors of Basal Cell Carcinoma
    Epidemiology
    Introduction
    Geography
    Demographics
    Location and Histologic Subtype
    Morbidity and Mortality
    Economic Burden
    Prevention
    Risk Factors
    Introduction
    UV Radiation
    Photosensitizing Medications
    Ionizing Radiation
    Chemical Exposures
    Immunosuppression
    Genes
    Conclusion
    References
    Chapter 2: Pathophysiology of Basal Cell Carcinoma and Its Associated Genetic Syndromes
    Introduction Basal Cell Nevus Syndrome (BCNS)
    Bazex-Dupre-Christol Syndrome
    Rombo Syndrome
    Additional Genetic Syndromes with Increased Risk of Basal Cell Carcinoma
    References
    Chapter 3: Histopathology of Basal Cell Carcinoma and Its Variants
    Introduction
    Common Histologic Features
    Histologic Variants
    Nodular Basal Cell Carcinoma
    Superficial Basal Cell Carcinoma
    Infundibulocystic/Hamartomatous Basal Cell Carcinoma
    Fibroepithelioma of Pinkus
    Infiltrative Basal Cell Carcinoma
    Morpheaform Basal Cell Carcinoma
    Micronodular Basal Cell Carcinoma Clear Cell Basal Cell Carcinoma
    Adenoid Basal Cell Carcinoma
    Pleomorphic Basal Cell Carcinoma
    Keratotic Basal Cell Carcinoma
    Basal Cell Carcinoma with Matrical Differentiation
    Basal Cell Carcinoma with Ductal Differentiation
    Metaplastic Basal Cell Carcinoma
    High-Risk Features
    References
    Chapter 4: Topical Therapy for the Treatment of Basal Cell Carcinoma
    Introduction
    Background
    Mechanism of Action
    Imiquimod
    5-Fluorouracil
    Ingenol Mebutate
    Efficacy
    Imiquimod
    5-Fluorouracil
    Ingenol Mebutate
    Safety
    Imiquimod
    5-Fluorouracil Ingenol Mebutate
    Comparative Studies
    Imiquimod
    Comparison of Different Treatment Regimens of Imiquimod to Vehicle Cream
    Comparison of Imiquimod to Other Treatment Modalities
    5-Fluorouracil
    Ingenol Mebutate
    Emerging Topical Treatments and Combination Therapies
    Combination Therapies
    Imiquimod Plus CT
    Imiquimod Plus PDT
    Imiquimod Plus Curettage
    Imiquimod Plus MMS
    5-FU Combination Therapy
    Discussion and Conclusions
    References
    Chapter 5: Local Immunotherapy for Basal Cell Carcinoma with Interferon
    Introduction
    Background Role of the Immune System
    Treatment with Immunostimulatory Agents (ISRX)
    Efficacy
    Low Recurrence Rate
    Normal Skin Markings
    Cosmesis
    Preservation of Function
    No Wound
    All Other Therapeutic Options Remain Open
    Disadvantages of ISRX
    Mechanism of Action of ISRX
    Patient/Tumor Selection
    Interferon Injections
    Preparation of IFN for Injection
    Injection Technique
    Dosage of IFN
    Combination of IFN with IMIQ
    Side Effects
    Recommended Follow-Up for BCC Treated with ISRX
    Conclusion
    References
    Digital Access Springer 2020