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  • Book
    edited by Ji-Yang Wang.
    Summary: This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.

    Contents:
    B cell development and maturation
    B cell receptor signalling
    Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger
    Germinal center reaction
    Memory B cells in local and systemic sites
    Regulation of plasma cell differentiation
    Regulation of humoral immune responses and B cell tolerance by the IgM Fc receptor
    Regulatory B cells
    Diversified IgA-bacteria interaction in gut homeostasis
    Primary antibody deficiencies
    B cell-mediated autoimmune diseases
    B cell lymphomas.
    Digital Access Springer 2020