Books

::Summary## Lists and classifies the plants of Syria, Palestine, and Egypt.<br/>::Contents##<br/>al-Mujallad<br/> 1. Wa-huwa yataḍammanu tisʻan wa-arbaʻīn rutbah min al-Shaqīqīyah ilā al-Kūrnīyah.

::Summary## This book provides a comprehensive overview of the diagnosis and management of Non-alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatis (NASH). Basic principles of disease progression, the genetic and nutritional basis of NAFLD and NASH are explained along with the proteomic principles underlying biomarker development. Chapters cover both biochemical and imaging biomarkers used in elastrography and ultrasound and discuss how these are applicable to early diagnosis and monitoring of NASH and NAFLD. This is a useful resource for hepatologists, primary care providers with an interest in metabolic disease, diabetologists and endocrinologists in their daily clinical practice.

::Summary## "This book is designed to meet the need for a concise, easy-to-read text on how to approach and manage patients with nail diseases. The book opens with a description of nail anatomy and physiology, followed by a review of nail symptoms, divided according to the part of the nail apparatus involved. Non-invasive and invasive tools for the diagnosis of nail disorders are then described and insights provided into their appropriate use. Subsequent chapters review the various nail diseases, covering inflammatory, infective, environmentally and auto- induced, drug-induced and neoplastic conditions as well as disorders due to systemic diseases. An additional chapter addresses nail conditions commonly seen in toenails. Informative high-quality illustrations are included for each disorder and boxes helpfully summarize the most important features, clues to diagnosis, necessary examinations, and treatments. Nail Disorders: A Practical Guide to Diagnosis and Management will be an invaluable, ready source of information for students in dermatology, clinical practitioners and podiatrists."--Publisher's website.

::Summary## Nail psoriasis is very common and causes considerable morbidity to patients. With the aid of informative illustrations, this book presents the clinical signs suggestive of nail psoriasis and describes the differential diagnosis of nail abnormalities. Newer methods of diagnosis are considered, and advice is provided on the use of severity evaluation indexes. The available treatments are extensively discussed, with information on the latest options. Selection of the appropriate treatment may be a challenge, so guidance is provided on all factors that should be taken into consideration and on choice of treatment for special categories of patient, such as children and pregnant women. Contributors have been selected from across the world, offering an international perspective on the condition. Nail Psoriasis will be an invaluable up-to-date source of information for dermatologists and will also be of interest to rheumatologists and general practitioners, given that recognition of nail signs can lead to earlier diagnosis of arthropathic disease.<br/>::Contents##<br/>Epidemiology of Nail Psoriasis<br/>Genetics<br/>Pathology<br/>Comorbidities of Nail Psoriasis: From A to Z<br/>Arthritis<br/>The Clinical Features of Nail Psoriasis<br/>Ultrasound Imaging of Psoriatic Nails <br/>Dermoscopy of Nail Psoriasis<br/>Severity Evaluation Indexes<br/>Quality of Life<br/>Differential Diagnosis for Nail Psoriasis<br/>Onychomycosis and Psoriasis<br/>Treatment of Nail Psoriasis<br/>Nail Psoriasis in Special Populations: Children, Pregnant, Elderly<br/>How to Choose My Treatment<br/>What Is the Future?

::Summary## A comprehensive introduction to nano- and biomaterials shining light on the different research disciplines from various perspectives. The straightforward and well-structured concept is designed to cater for entrants as well as experienced researchers in the field of nanotechnology. The initial chapters introduce nanomaterials, their classification and synthesis techniques, while subsequent chapters discuss the various characterization tools as well as mechanical properties and their applications in biotechnological and biomedical fields. Further understanding of the topic is supported by case studies used for practical purposes. The book concludes with a look at future technology advances. With its explanation of a wide variety of materials, this is an essential reference for chemists, physicists, materials scientists and biomedical engineers.<br/>::Contents##<br/>Introduction into Nano- and Biomaterials<br/>Classification of Nanomaterials<br/>Nanocomposite Materials and Their Physical Property Features<br/>Mechanical Characteristics of Dispersive Systems<br/>Physical Properties of Nanomaterials: Graphene<br/>Chemical Properties and Mechanical Characteristics of Nanomaterial Characterization Tools in Nanotechnology<br/>Introduction to Biomaterials<br/>Properties of Biomaterials<br/>Implants and Artificial Organs<br/>Tissue Engineering, Scaffolds, and 3D Bioprinting.

::Summary## In this age of population explosion and depleting natural resources, this book offers new techniques to produce more from agricultural crops at a lower cost. The field of agronomy addresses this issue and interacts with the fields of agriculture, botany, and economics. Nanotechnology and nanoparticles play a role in agronomy. This book joins techniques from both fields into once comprehensive volume. Students of agriculture, physics, nanotechnology, and plant sciences will benefit equally from this work.<br/>::Contents##<br/>Intro<br/>Preface<br/>Contents<br/>About the Editor<br/>Chapter 1: Nanotechnology: A Breakthrough in Agronomy<br/>1.1 Introduction<br/>1.2 What Is Nanotechnology?<br/>1.3 Classification of Nanomaterials<br/>1.3.1 One-Dimensional Nanoparticles<br/>1.3.2 Two-Dimension Nanoparticles<br/>1.3.3 Three-Dimension Nanoparticles<br/>1.4 Synthesis of Nanomaterials<br/>1.4.1 Top to Bottom Approach<br/>1.4.2 Bottom to Up Approach<br/>1.4.2.1 Chemical Synthesis<br/>1.4.2.2 Biological Synthesis<br/>Nanoparticle Synthesis Using Microorganisms<br/>Green Synthesis 1.5 Overview of Nano-technological Applications in Agriculture<br/>1.5.1 Crop Production and Growth<br/>1.5.1.1 Seed Production<br/>1.5.1.2 Seed Germination<br/>1.5.1.3 Nanofertilizer<br/>1.5.2 Crop Disease Management<br/>1.5.2.1 Nanopestiside<br/>1.5.2.2 Nanofungicide<br/>1.5.2.3 Nanoherbicide<br/>1.5.2.4 Nanofibers<br/>1.5.3 Nanoparticles in Post-harvest Disease Management<br/>1.5.4 Nanoscale Carriers<br/>1.5.5 Nanosensors<br/>1.5.6 Sustainable Water Use<br/>1.5.7 Removal of Heavy Metals<br/>1.5.8 Hydroponics<br/>1.5.9 Nanoparticles in Plant Tissue Culture<br/>1.6 Conclusion<br/>References 4.2.3 Take-All of Wheat<br/>4.2.4 Downy Mildews<br/>4.2.5 Leaf Spot and Blight Diseases<br/>4.2.6 Grey Mold Disease<br/>4.2.7 Rusts<br/>4.2.8 Smuts<br/>4.2.9 Anthracnose<br/>4.3 Role of Fungi in Nanoparticles Synthesis<br/>4.3.1 Mechanisms Behind Myconanoparticles Synthesis<br/>4.3.2 Fungi a Renewable Source for Nanoparticles Synthesis<br/>4.4 Myconanoparticles Application in Management of Fungal Diseases<br/>4.4.1 Nanoparticles as a Suppresser for Pests (Nanopesticides)<br/>4.4.2 Myconanoparticles Mechanism of Action Against Fungal Pathogens<br/>4.5 Future Prospective<br/>References Chapter 2: Nanotechnology and Plant Tissue Culture<br/>2.1 Introduction<br/>2.2 Plant Tissue Culture<br/>2.2.1 Nanoparticles in Tissue Culture<br/>2.2.2 Nanomaterials and Surface Sterilization of Explants<br/>2.2.3 Role of Nanoparticles in Callogenesis, Organ Induction, Shoot and Root Growth<br/>2.2.4 Effect of Nanomaterials on Genetic Transformation<br/>2.2.5 In Vitro Conservation<br/>2.2.6 Nanomaterials May Lead to Somaclonal Differences<br/>2.2.7 Nanomaterials Cause Enhancement of Secondary Metabolites<br/>2.3 Are Nanoparticles Toxic in Plant Tissue Culture?<br/>2.4 Future Projections<br/>2.5 Conclusion

::Contents##<br/>Encapsulating proteins in nanoparticles: batch by batch or one by one<br/>Enzyme adsorption on nanoparticle surface probed by highly sensitive second harmonic light scattering<br/>Armoring enzymes by metal-organic frameworks by the coprecipitation method<br/>Enzyme armoring by an organosilica layer: synthesis and characterization of hybrid organic/inorganic nanobiocatalysts<br/>Strategies for biophysical characterization of protein-polymer conjugates<br/>Guide to the preparation of molecularly imprinted polymer nanoparticles for protein recognition by solid-phase synthesis<br/>Armored urease: enzyme-bioconjugated poly(acrylamide) hydrogel as a storage and sensing platform<br/>Armored enzyme-nanohybrids and their catalytic function under challenging conditions<br/>Approaches for conjugating tailor-made polymers to proteins<br/>Nanoarmoring of enzymes by polymer-functionalized iron oxide nanoparticles<br/>Expression of cellulytic enzyme as a fusion protein that reacts specifically with a polymeric scaffold<br/>Nanoarmoring of proteins by conjugation to block copolymer micelles<br/>Semisynthetic enzymes by protein-peptide site-directed covalent conjugation: methods and applications<br/>Transgultaminase-mediated nanoarmoring of enzymes by PEGylation<br/>Polymer-based protein engineering: synthesis and characterization of armored, high graft density polymer-protein conjugates<br/>Nano-armoring of enzymes: rational design of polymer-wrapped enzymes<br/>Nanoarmored enzymes for organic enzymology: synthesis and characterization of poly(2-alkyloxazoline)-enzyme conjugates<br/>Preparation and applications of dendronized polymer-enzyme conjugates<br/>Nanoarmoring of enzymes by interlocking in cellulose fibers with poly(acrylic acid)<br/>Author index<br/>Subject Index.

::Contents##<br/>Magneto-controlled enzyme reactions / Paolo Bollella and Evgeny Katz<br/>Functionalization of multiwalled carbon nanotubes for enzyme immobilization / Ram Sarup Singh and Kanika Chauhan<br/>Immobilization of enzymes on iron oxide magnetic nanoparticles : synthesis, characterization, kinetics and thermodynamics / Abhijeet B. Muley, Ketan H. Mulchandani, and Rekha S. Singhal<br/>Strategies to rationalize enzyme immobilization procedures / Diego E. Sastre, Eduardo A. Reis, and Caterina G.C. Marques Netto<br/>Fibrous polymer functionalized magnetic biocatalysts for improved performance / Veli C. Ozalp, Gulay Bayramoglu, and M. Yakup Arica<br/>Improvement in biochemical characteristics of cross-linked enzyme aggregates (CLEAs) with magnetic nanoparticles as support matrix / Nithyakalyani Doraiswamy, Mahalakshmi Sarathi, and Gautam Pennathur<br/>Magnetic bead-based semi-automated phage display panning strategy for the directed evolution of antibodies / Angela Chiew Wen Ch'ng, Zoltán Konthur, and Theam Soon Lim<br/>On-bead enzyme-catalyzed signal amplification for the high-sensitive detection of disease biomarkers / Wenjiao Fan, Wei Ren, Liping Zhu, and Chenghui Liu<br/>Organophosphonate functionalized Au/Si@Fe₃O₄ : versatile carrier for enzyme immobilization / Sunaina Kaul, Vishal Singh, Rajat Sandhir, and Nitin Kumar Singhal<br/>Bioelectrocatalysis at carbon nanotubes / Paolo Bollella and Evgeny Katz<br/>Molecular wiring of glucose oxidase enzyme with Mn polypyridine complex on MWCNT modified electrode surface and its bio-electrocatalytic oxidation and glucose sensing / Natarajan Saravanan and Annamalai Senthil Kumar<br/>Use of functionalized carbon nanotubes for the development of robust nanobiocatalysts / Michaela Patila, Nikolaos Chalmpes, Evangelia Dounousi, Haralambos Stamatis, and Dimitrios Gournis<br/>Biocatalytic hydrogenations on carbon supports / Lisa A. Thompson, Jack S. Rowbotham, Holly A. Reeve, Ceren Zor, Nicole Grobert, and Kylie A. Vincent<br/>Nano-immobilized cellulases for biomass processing with application in biofuel production / Reinu E. Abraham and Munish Puri<br/>Few biomedical applications of carbon nanotubes / Neelam Yadav, Manshi Tyagi, Shikha Wadhwa, Ashish Mathur, and Jagriti Narang<br/>Multiwalled carbon nanotubes bound beta-galactosidase : it's activity, stability and reusability / Maryam Khan and Qayyum Husain<br/>Exfoliated and water dispersible biocarbon nanotubes for enzymology applications / Ankarao Kalluri, Megan K. Puglia, Mansi Malhotra, and Challa V. Kumar<br/>Stabilization of phytase on multi-walled carbon nanotubes via covalent immobilization / Mohammad Pooya Naghshbandi and Hamid Moghimi<br/>A simple magnetic nanoparticle-poly-enzyme nanobead sandwich assay for direct, ultrasensitive DNA detection / Lorico D.S. Lapitan, Jr. and Dejian Zhou<br/>Enzymes immobilization onto magnetic nanoparticles to improve industrial and environmental applications / Osama M. Darwesh, Sameh S. Ali, Ibrahim A. Matter, Tamer Elsamahy, and Yehia A. Mahmoud.

::Summary## This book comprehensively documents the application of Nanobiomaterials in the field of bio-medicine and diagnostics technologies by involving classical concepts/examples. Nanobiotechnology is an emerging area which encompasses all the facets of research of nano and biomaterials with their interaction with biological systems. The book summarises design and development of various nanobiomaterials and their composites for diagnostics and therapeutic applications. It skilfully reviews the utilization of the nanomaterials alone or in combination with other bio-molecules as a contrast enhancer in in-vivo imaging, Nano-Theranostics, drug delivery, and sensing transducer matrix. It also discusses the current research on designing of the new Nanobiomaterials and their implementation in numerous fields including bio-medicine and diagnostics. Finally, it summarizes the future prospects and the commercial viability of Nanobiomaterials in the human health care.<br/>::Contents##<br/>Chapter 1. Nanomaterials, classifications, and properties<br/>Chapter 2. Engineering nanomaterials for bio-interfacing<br/>Chapter 3. Biomaterials and surface modification strategies<br/>Chapter 4. Nano materials as a nanotheronostic agent<br/>Chapter 5. Nanobiomaterials in biomedicine: Designing strategies and critical concepts<br/>Chapter 6. Phytofabricated nanodelivery systems: Engineering principles and applications<br/>Chapter 7. Nanobiosensors based diagnostics system: Transducers and surface materials<br/>Chapter 8. Nanobiomaterials and nanocomposites in clinical diagnostics<br/>Chapter 9. Tissue Engineering and Regenerative Medicines based on nanobiomaterials<br/>Chapter 10. Prospects and advantages of microfluidics utilizing various nanobiomaterials<br/>Chapter 11. Electrochemical nanoengineered sensors in infectious disease diagnosis<br/>Chapter 12. Multiplexing utilizing various nanobiomaterials<br/>Chapter 13. Future perspects of nanobiomaterials in human health care<br/>Chapter 14. Commercial aspects of nanobiomaterials: Short-coming and future aspects.

::Summary## Written by an international team of editors and contributors from renowned universities and institutes, this book addresses the latest research in the field of nanobiomaterials, covering nanotechnologies for their fabrication, developments in biomedical applications, and the challenges of biosafety in clinic uses. Clearly structured, the volume defines the scope and classification of the field, resulting in a broad overview from fundamental principles to current technological advances, and from materials synthesis to biomedical applications along with future trends.<br/>::Contents##<br/>Introduction. Nanobiomaterials: State of the Art / Jing Wang, Huihua Li, Lingling Tian, Seeram Ramakrishna<br/>Classification of Nanobiomaterials. Metallic Nanobiomaterials / Magesh Sankar, Vasanth Gopal, Revathi Alexander, Geetha Manivasagam, Murugan Ramalingam<br/>Polymeric Nanobiomaterials / Deepti Rana, Keerthana Ramasamy, Samad Ahadian, Geetha Manivasagam, Xiumei Wang, Murugan Ramalingam<br/>Carbon-Based Nanobiomaterials / Samad Ahadian, Farhad Batmanghelich, Raquel Obregón, Deepti Rana, Javier Ramón-Azcón, Ramin Banan Sadeghian, Murugan Ramalingam<br/>Nanotechnology-Based Approaches in Biomaterials Fabrications. Molecular Self-Assembly for Nanobiomaterial Fabrication / Ling Zhu, Yanlian Yang, Chen Wang<br/>Electrospraying and Electrospinning for Nanobiomaterial Fabrication / Liumin He, Yuyuan Zhao, Lingling Tian, Seeram Ramakrishna<br/>Layer-by-Layer Technique: From Capsule Assembly to Application in Biological Domains / Xi Chen<br/>Nanopatterning Techniques / Lakshmi Priya Manickam, Akshay Bhatt, Deepti Rana, Serge Ostrovidov, Renu Pasricha, Xiumei Wang, Murugan Ramalingam<br/>Surface Modification of Metallic Implants with Nanotubular Arrays via Electrochemical Anodization / Ming Jin, Shenglian Yao, Luning Wang<br/>Nanobiomaterials in Biomedical Applications: Diagnosis, Imaging, and Therapy. Nonconventional Biosensors Based on Nanomembrane Materials / Lan Yin, Xing Sheng<br/>Nanobiomaterials for Molecular Imaging / Prashant Chandrasekharan, Chang-Tong Yang<br/>Engineering Nanobiomaterials for Improved Tissue Regeneration / Liping Xie, Wei Qian, Jianjun Sun, Bo Zou<br/>Nanobiomaterials for Cancer Therapy / Wei Tao, Lin Mei<br/>Chemical Synthesis and Biomedical Applications of Iron Oxide Nanoparticles / Jing Yu, Yanmin Ju, Fan Chen, Shenglei Che, Lingyun Zhao, Fugeng Sheng, Yanglong Hou<br/>Gold Nanoparticles and Their Bioapplications / Heyun Shen, Li Cheng, Linlin Li, Huiyu Liu<br/>Silicon-Based Nanoparticles for Drug Delivery / Yixuan Yu, Xi Liu<br/>Dendritic-Polymer-Based Nanomaterials for Cancer Diagnosis and Therapy / Na Zhu, Qiyong Gong, Zhongwei Gu, Kui Luo<br/>Biosafety and Clinical Translation of Nanobiomaterials. Biosafety of Carbon-Based Nanoparticles and Nanocomposites / Yong Cheol Shin, Jong Ho Lee, In-Seop Lee, Dong-Wook Han<br/>Clinical Translation and Safety Regulation of Nanobiomaterials / Ruibo Zhao, Lawrence Keen, Xiangdong Kong.

::Summary## This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.<br/>::Contents##<br/>Chapter 1. Current Advances in Nanotechnology and Medicine<br/>Chapter 2. Least Explored Small Wonders: Nano-biotechnology<br/>Chapter 3. Modern Approaches in Nanomedicine for neuroAIDS and CNS drug delivery<br/>Chapter 4. Nanobiotechnology: Paving the way to personalized medicine<br/>Chapter 5. Nanomedicine in cancer stem cell therapy<br/>Chapter 6. Nanobiosensor: Current Trends and Applications<br/>Chapter 7. Transition Metal Oxide Nanoparticles: A New Horizon in Cancer Treatment<br/>Chapter 8. Nanomedicine meets microRNA expression and function in prostate cancer<br/>Chapter 9. Biomedical applications of Viral Nanoparticles in vaccine therapy<br/>Chapter 10. HIV: Biology to Nanomedicine<br/>Chapter 11. Current Advances in Phage Inspired Nanocarriers Based Therapy<br/>Chapter 12. Nanophytotherapeutic potential of Essential Oils against Candida infections<br/>Chapter 13. Molecular tests for the Diagnosis of Tuberculosis: Nanodiagnostics Approaches<br/>Chapter 14. Molecular Mechanisms of drug resistance in Mycobacterium tuberculosis: Role of nanoparticles against Multi-Drug Resistant tuberculosis (MDR-TB)<br/>Chapter 15. Nano-Mass spectrometry (nano-MS) based lipidomics<br/>Chapter 16. Techniques to understand Mycobacterial Lipids and use of Lipid Based Nanoformulations for Tuberculosis Management<br/>Chapter 17. Recent trends and challenges in Patches for cardiac tissue reengineering: role of Nanomaterials<br/>Chapter 18. Cyclic dinucleotides: Big roles of small molecules and its role in nanotechnology and medicine<br/>Chapter 19. Antibodies: Biology to Therapeutics and its role in nanomedicine<br/>Chapter 20. Nanotoxicology in Medicine<br/>Chapter 21. Antibody-targeted nanoparticles for cancer treatment<br/>Chapter 22. Nanoparticle mediated combined photothermal and photodynamic therapy<br/>Chapter 23. Nanotechnology based devices and its applications in medicine- Chapter 24. Opportunities in clinical translation and commercialization of nanomedicine.

::Summary## This book examines the role of nanobiosensors in point-of-care applications for personalized healthcare and management. It begins by discussing various biomaterials that are used for the development of biosensors in medical diagnostics, and reviews advances in their fabrication and the miniaturization of biosensor devices for lab-on-chip analysis. In turn, it explores the rapidly evolving applications of nanomaterials in the context of biomaterial diagnostics. The book also explores the immense potential of biosensors in medical diagnostics, where they are increasingly being used to detect a wide range of biomolecules and biomarkers. In closing, it discusses the current challenges and outlines the future role of nanobiosensors in the development of next-generation point-of-care applications.<br/>::Contents##<br/>Chapter 1. Point of Care biosensors for healthcare applications<br/>Chapter 2. An overview of biomolecules used in the development of point of care sensor<br/>Chapter 3. Nanomaterials for POC biosensors<br/>Chapter 4. New generation molecular techniques in POC biosensors for detection of infectious diseases<br/>Chapter 5. Point-of-Care Biosensors for Glucose Sensing<br/>Chapter 6. Overview of Affordable Upfront Point-of-Care Testing for Cancer Detection<br/>Chapter 7. Point-of-care Diagnostic Testing in Urgent Cardiac Care<br/>Chapter 8. Point-of-Care Nanobiosensors for Determining Vitamin Deficiency<br/>Chapter 9. Utility of Nanobiosensors as a Point of Care Diagnostics for Neurological Disorders: From Bench to Bedside<br/>Chapter 10. Point-of-Care Testing and Diagnostics for Sexually Transmitted Disease<br/>Chapter 11. Nano-Biosensor Based Microfluidic Point-Of-Care Platforms: Fabrication, Characterization, And Applications<br/>Chapter 12. Nanobiosensor: Advancement in Disease Diagnostic.

::Contents##<br/>[v. 1]. Concepts, applications, and perspectives<br/>1 . Biocompatible inorganic devices / Thomas Sawitowski<br/>2. Microfluidics meets nano : lab-on-a-chip devices and their potential for nanobiotechnology / Holger Bartos, Friedrich Götz, and Ralf-Peter Peters<br/>3. Microcontact printing of proteins / Emmanuel Delamarche<br/>4. Cell-nanostructure interactions / Joachim P. Spatz<br/>5. Defined networks of neuronal cells in vitro / Andreas Offenhäusser and Angela K. Vogt<br/>6. S-Layers / Uwe B. Sleytr ... [et al.]<br/>7. Engineered nanopores / Hagan Bayley ... [et al.]<br/>8. Genetic approaches to programmed assembly / Stanley Brown<br/>9. Microbial nanoparticle production / Murali Sastry ... [et al.]<br/>10. Magnetosomes : nanoscale magnetic iron minerals in bacteria / Richard B. Frankel and Dennis A. Bazylinski<br/>11. Bacteriorhodopsin and its potential in technical applications / Norbert Hampp and Dieter Oesterhelt<br/>12. Polymer Nanocontainers / Alexandra Graff ... [et al.]<br/>13. Biomolecular motors operating in engineered environments / Stefan Diez, Jonne H. Helenius, and Jonathon Howard<br/>14. Nanoparticle-biomaterial hybrid systems for bioelectronic devices and circuitry / Eugenii Katz and Itamar Willner<br/>15. DNA-protein nanostructures / Christof M. Neimeyer<br/> 16. DNA-templated electronics / Erez Braun and Uri Sivan<br/>17. Biomimetic fabrication of DNA-based metallic nanowires and networks / Michael Mertig and Wolfgang Pompe<br/>18. Mineralization in nanostructured biocompartments : biomimetic ferritins for high-density data storage / Eric L. Mayes and Stephen Mann<br/>19. DNA-gold nanoparticle conjugates / C. Shad Thaxton and Chad A. Mirkin<br/>20. DNA nanostructures for mechanics and computing : nonlinear thinking with life's central molecule / Nadrian C. Seeman<br/>21. Nanoparticles as non-viral transfection agents / M.N.V. Ravi Kumar, Udo Bakowsky, and Claus-Michael Lehr<br/>22. Luminescent quantum dots for biological labeling / Xiaohu Gao and Shuming Nie<br/>23. Nanoparticle molecular labels / James F. Hainfeld, Richard D. Powell, and Gerhard W. Hacker<br/>24. Surface biology : analysis of biomolecular structure by atomic force microscopy and molecular pulling / Emin Oroudjev, Signe Danielsen and Helen G. Hansma<br/>25. Force spectroscopy / Markus Seitz<br/>26. Biofunctionalized nanoparticles for surface-enhanced raman scattering and surface plasmon resonance / Mahnaz El-Kouedi and Christine D. Keating<br/>27. Bioconjugated silica nanoparticles for bioanalytical applications / Timothy J. Drake, Xiaojun Julia Zhao, and Weihong Tan.<br/>v. 2. More concepts and applications<br/>Part I. Self-Assembly and Nanoparticles: Novel Principles<br/>ch. 1. Self-Assembled Artificial Transmembrane Ion Channels / Mary S. Gin, Emily G. Schmidt and Pinaki Talukdar, p. 1-15<br/>ch. 2. Self-Assembling Nanostructures from Coiled-Coil Peptides / Maxim G. Ryadnov and Derek N. Woolfson, p. 17-38<br/>ch. 3. Synthesis and Assembly of Nanoparticles and Nanostructures Using Bio-Derived Templates / Erik Dujardin and Stephen Mann, p. 39-63<br/>ch. 4. Proteins and Nanoparticles: Covalent and Noncovalent Conjugates / Rochelle R. Arvizo, Mrinmoy De and Vincent M. Rotello, p. 65-78<br/>ch. 5. Self-Assembling DNA Nanostructures for Patterned Molecular Assembly / Thomas H. LaBean, Kurt V. Gothelf and John H. Reif, p. 79-97<br/>ch. 6. Biocatalytic Growth of Nanoparticles for Sensors and Circuitry / Ronan Baron, Bilha Willner and Itamar Willner, p. 99-121<br/>Part II. Nanostructures for Analytics<br/>ch. 7. Nanoparticles for Electrochemical Bioassays / Joseph Wang, p. 123-140<br/>ch. 8. Luminescent Semiconductor Quantum Dots in Biology / Thomas Pons, Aaron R. Clapp, Igor L. Medintz and Hedi Mattoussi, p. 141-157<br/>ch. 9. Nanoscale Localized Surface Plasmon Resonance Biosensors / Katherine A. Willets, W. Paige Hall, Leif J. Sherry, Xiaoyu Zhang, Jing Zhao and Richard P. Van Duyne, p. 159-173<br/>ch. 10. Cantilever Array Sensors for Bioanalysis and Diagnostics / Hans Peter Lang, Martin Hegner and Christoph Gerber, p. 175-195<br/>ch. 11. Shear-Force-Controlled Scanning Ion Conductance Microscopy / Tilman E. Schäffer, Boris Anczykowski, Matthias Böcker and Harald Fuchs, p. 197-212<br/>ch. 12. Label-Free Nanowire and Nanotube Biomolecular Sensors for In-Vitro Diagnosis of Cancer and other Diseases / James R. Heath, p. 213-232<br/>ch. 13. Bionanoarrays / Rafael A. Vega, Khalid Salaita, Joseph J. Kakkassery and Chad A. Mirkin, p. 233-259<br/>Part III. Nanostructures for Medicinal Applications --. ch. 14. Biological Barriers to Nanocarrier-Mediated Delivery of Therapeutic and Imaging Agents, p. 261-284 / Rudy Juliano<br/>ch. 15. Organic Nanoparticles: Adapting Emerging Techniques from the Electronics Industry for the Generation of Shape-Specific, Functionalized Carriers for Applications in Nanomedicine / Larken E. Euliss, Julie A. DuPont and Joseph M. DeSimone, p. 285-303<br/>ch. 16. Poly(amidoamine Dendrimer-Based Multifunctional Nanoparticles / Thommey P. Thomas, Rameshwer Shukla, Istvan J. Majoros, Andrzej Myc and James R. Baker, p. 305-319<br/>ch. 17. Nanoparticle Contrast Agents for Molecular Magnetic Resonance Imaging / Young-Wook Jun, Jae-Hyun Lee and Jinwoo Cheon, p. 321-346<br/>ch. 18. Micro- and Nanoscale Control of Cellular Environment for Tissue Engineering / Ali Khademhosseini, Yibo Ling, Jeffrey M. Karp and Robert Langer, p. 347-364<br/>ch. 19. Diagnostic and Therapeutic Targeted Perfluorocarbon Nanoparticles / Patrick M. Winter, Shelton D. Caruthers, Gregory M. Lanza and Samuel A. Wickline, p. 365-380<br/>Part IV. Nanomotors<br/>ch. 20. Biological Nanomotors / Manfred Schliwa, p. 381-399<br/>ch. 21. Biologically Inspired Hybrid Nanodevices / David Wendell, Eric Dy, Jordan Patti and Carlo D. Montemagno, p. 401-418.

::Summary## Nanobiotechnology Applications in Plant Protection: Volume 2 continues the important and timely discussion of nanotechnology applications in plant protection and pathology, filling a gap in the literature for nano applications in crop protection. Nanobiopesticides and nanobioformulations are examined in detail and presented as powerful alternatives for eco-friendly management of plant pathogens and nematodes. Leading scholars discuss the applications of nanobiomaterials as antimicrobials, plant growth enhancers and plant nutrition management, as well as nanodiagnostic tools in phytopathology and magnetic and supramagnetic nanostructure applications for plant protection. This second volume includes exciting new content on the roles of biologically synthesized nanoparticles in seed germination and zinc-based nanostructures in protecting against toxigenic fungi. Also included is new research in phytotoxicity, nano-scale fertilizers and nanomaterial applications in nematology and discussions on Botyris grey mold and nanobiocontrol. This book also explores the potential effects on the environment, ecosystems and consumers and addresses the implications of intellectual property for nanobiopesticides. Further discussed are nanotoxicity effects on the plant ecosystem and nano-applications for the detection, degradation and removal of pesticides.<br/>::Contents##<br/>Intro; Preface; Contents; Contributors; About the Editors; <br/>Chapter 1: Intellectual Property Rights in Nano-biopesticides; 1.1 Nano-biopesticides-An Overview; 1.2 Intellectual Property Rights-Where Does IPR Meet Nano-biopesticides; 1.3 Introduction to IPR Tools (WIPO and WTO); 1.4 Patenting Trends in Nano-biopesticides; 1.5 Mitigating Potential Risks; 1.6 Conclusion; References; <br/>Chapter 2: Application of Nanomaterials in Plant Disease Diagnosis and Management; 2.1 Introduction; 2.2 Application of Nanomaterials in the Detection and Diagnosis of Plant Diseases 2.3 Application of Nanoparticles and Nanomaterials in Plant Disease Management2.3.1 Effect of Nanoparticles on Plant Pathogenic Fungi; 2.3.1.1 Silver Nanoparticles; 2.3.1.2 Zinc Nanoparticles; 2.3.1.3 Sulfur Nanoparticles; 2.3.1.4 Copper Nanoparticles; 2.3.2 Effect of Nanoparticles on Bacteria; 2.3.2.1 Silver Nanoparticles; 2.3.2.2 Zinc Nanoparticles; 2.3.2.3 Copper Nanoparticles; 2.3.2.4 Other Nanoparticles; 2.4 Conclusion; References; <br/>Chapter 3: Bio-Engineered Nanomaterials for Plant Growth Promotion and Protection; 3.1 Introduction; 3.1.1 Nano-Biotechnology; 3.1.2 Nano-Nutrition 3.2 Green Nanoparticles for Plant Growth Promotion and Protection3.2.1 Effect of Nano-carbon on Plant Growth Promotion and Protection; 3.2.1.1 Effect of Fullerene; 3.2.1.2 Effects of Single-Walled Carbon Nanotubes (SWCNTs) and Multiwalled Carbon Nanotubes (MWCNTS); 3.3 Metal Nanoparticles; 3.3.1 Cu and CuO Nanoparticles; 3.3.2 ZnO Nanoparticles; 3.3.3 TiO2 Nanoparticles; 3.3.4 Silver Nanoparticles; 3.3.5 CeO2 Nanoparticles; 3.3.6 SiO2 Nanoparticles; 3.3.7 Gold Nanoparticles; 3.3.8 Iron Oxide Nanoparticles; 3.4 Conclusions; References <br/>Chapter 4: Zinc-Based Nanostructures in Plant Protection Applications4.1 Introduction; 4.2 Applications; 4.2.1 Pesticides; 4.2.2 Insecticides; 4.2.3 Postharvest Applications; 4.2.4 Zinc-Based Nanomaterials Against Plant Pathogens; 4.2.5 Positive Effects of Zn NPs on Plant Growth; 4.2.6 Negative Effects of Zn NPs on Plant Growth; 4.2.7 Fertilizers; 4.2.8 Pesticide Nanosensing and Photocatalytic Degradation; 4.2.9 Effect of ZnO NPs on Soil Microbial Activity; 4.3 Microbial Mechanism; 4.4 Phytotoxicity; 4.5 Conclusion; References <br/>Chapter 5: Botrytis Gray Mold Nano- or Biocontrol: Present Status and Future Prospects5.1 Introduction; 5.2 Synthetic Fungicides; 5.2.1 Prospects Concerning Synthetic Fungicide Application; 5.2.2 Fungicide Resistance; 5.3 Nanofungicides; 5.3.1 Potential Implications of Nanofungicides; 5.4 Biofungicides; 5.4.1 Application of Biopolymers as Biofungicides; 5.4.2 Essential Oils as Potential Biofungicides; 5.4.3 Plant Extracts; 5.4.4 Biocontrol Agents; 5.4.4.1 Trichoderma Species; 5.4.4.2 Bacillus Species; 5.4.4.3 Yeasts as Potential Antagonists; 5.4.4.4 Phytochemicals and Antioxidants

::Summary## Agriculture is considered as a backbone of developing nations as it caters the needs of the people, directly or indirectly. The global agriculture currently faces enormous challenges like land degradation and reduced soil fertility, shrinking of land, low production yield, water accessibility and a dearth of labor due to evacuation of individuals from farming. Besides, the global population increases at an exponential rate and it is predicted that the global population will be 9 billion by 2050 that in turn leads to food crisis in near future. Although, green revolution revolutionizes the agriculture sector by enhancing the yield but it was not considered as a sustainable approach. Exorbitant use of chemical fertilizers and pesticides to boost the crop yield is definitely not a convenient approach for agriculture sustainability in the light of the fact that these chemical fertilizers are considered as double-edged sword, which on one hand enhance the crop yield but at the same time possess deleterious effect on the soil microflora and thus declines its fertility. Besides, it cause irreversible damage to the soil texture and disrupts the equilibrium in the food chain across ecosystem, which might in turn lead to genetic mutations in future generations of consumers. Thus, the increased dependence on fabricated agricultural additives during and post green revolution has generated serious issues pertaining to sustainability, environmental impact and health hazards. Therefore, nano-biotechnology has emerged as a promising tool to tackle the above problems especially in the agriculture sector. Nano-agribusiness is an emerged field to enhance crop yield, rejuvenate soil health, provide precision farming and stimulate plant growth. Nano-biotechnology is an essential tool in modern agriculture and is considered as a primary economic driver in near future. It is evaluated that joining of cutting edge nanotechnology in agribusiness would push the worldwide monetary development to approximately US$ 3.4 trillion by 2020 which clearly indicates that how agri-nanobiotechnology plays a pivotal role in the agricultural sector, without any negative impact on the environment and other regulatory issues of biosafety. Agri-nanobiotechnology is an innovative green technology, which provides the solution to global food security, sustainability and climate change. The current book is presenting the role of nano-biotechnology in modern agriculture and how it plays a pivotal role to boost the agri-business.<br/>::Contents##<br/>Intro<br/>Foreword<br/>Preface<br/>Contents<br/>About the Editors<br/>Nanotechnology: An Overview<br/>1 Introduction<br/>2 Categorization of Nano-agrochemicals<br/>2.1 Nano-fertilizers<br/>Nano-composite Polymers<br/>2.2 Nano-biosensors<br/>2.3 Nano-clays<br/>2.4 Nano-pesticides<br/>Formulations Aiming to Increase the Solubility of Poorly Water-Soluble Compounds<br/>3 Formulations Aimed for Controlled/Targeted Release and/or Protect Active Ingredients Against Premature Degradation<br/>3.1 Polymer-Based Formulations<br/>3.2 Porous Hollow Silica Nanoparticles<br/>3.3 Nano-metals 13 Conclusions<br/>References<br/>Nano-enabled Agriculture Can Sustain "Farm to Fork" Chain<br/>1 Introduction<br/>2 Disease Management Through Nanotechnology<br/>2.1 Nanobarcodes<br/>2.2 Nanosensors<br/>3 Enhanced Food Safety Through Sensors for the Detection of Pathogens or Freshness<br/>3.1 Freshness and Spoilage Indicators<br/>4 Nanotechnology in Enhancing Soil Security<br/>5 Important Nanoparticles in the Agro-Industry<br/>5.1 Chitosan Nanoparticles (CNP)<br/>5.2 TiO2 Nanoparticles<br/>5.3 Multi-Walled Carbon Nanotubes (MWCNTs) Nanoparticles<br/>5.4 Silicon Nanoparticles<br/>5.5 Zinc Oxide Nanoparticles 4 Nano-agrochemicals Versus Conventional Agrochemicals<br/>4.1 Solubility and Dispersion of Mineral Micro-nutrients<br/>4.2 Nutrient Uptake Efficiency<br/>4.3 Controlled Release Modes<br/>4.4 Effective Duration of Nutrient Release<br/>4.5 Loss Rate of Fertilizer Nutrients<br/>5 Conclusion and Future Perspective<br/>References<br/>Nanotechnology: A Boost for the Urgently Needed Second Green Revolution in Indian Agriculture<br/>1 Introduction<br/>2 Applications of Nanotechnology and Nanomaterials in Agriculture and Food Sector<br/>3 Nanotechnology and Agriculture Sector 4 Smart Delivery Systems for Pests, Nutrients, and Plant Hormones<br/>5 Nano-formulations for the Control of Plant Diseases<br/>5.1 Nanotechnology for Detecting Plant Diseases<br/>6 Plant Pathogens in Biosynthesis of Nanoparticles<br/>6.1 Fungi<br/>6.2 Bacteria<br/>6.3 Plant Virus<br/>7 Amalgamation of Nanotechnology and Crop Biotechnology<br/>8 Nanoparticles and Recycling Agricultural Waste<br/>9 Nanotechnology in Food Sector<br/>10 Risk Assessment of Nanomaterials in Agriculture and Food Sector<br/>11 Socio-Economic Issues of Agricultural Nanotechnology<br/>12 Current and Future Developments 6 Plant Induced Resistance Through Nanoparticles<br/>7 Engineered Water Nanostructures to Treat Food Surfaces to Reduce Pathogen Presence<br/>8 Therapeutic Nanoparticles Deliver Nutrients to Agricultural Crops Against Various Deficiencies<br/>9 Genetic Material Delivery via Nanoparticle-Mediated Chloroplast Transgene Delivery<br/>10 Conclusion and Perspective<br/>References<br/>Role of Nanotechnology in Crop Improvement<br/>1 Introduction<br/>2 Agro-Nanotechnology and Crop Improvement<br/>3 Role of Nanotechnology for Enhancement of Plant Biomass and Yield Production

::Summary## With the recent shift of chemical fertilizers and pesticides to organic agriculture, the employment of microbes that perform significant beneficial functions for plants has been highlighted. This book presents timely discussion and coverage on the use of microbial formulations, which range from powdered or charcoal-based to solution and secondary metabolite-based bioformulations. Bioformulation development of biofertilizers and biopesticides coupled with the advantages of nanobiotechnology propose significant applications in the agricultural section including nanobiosensors, nanoherbicides, and smart transport systems for the regulated release of agrochemical. Moreover, the formulation of secondary metabolites against individual phytopathogens could be used irrespective of geographical positions with higher disease incidences. The prospective advantages and uses of nanobiotechnology generate tremendous interest, as it could augment production of agricultural produce while being cost-effective both energetically and economically. This bioformulation approach is incomparable to existing technology, as the bioformulation would explicitly target the particular pathogen without harming the natural microbiome of the ecosystem. Nanobiotechnology in Bioformulations covers the constraints associated with large-scale development and commercialization of bioinoculant formations. Furthermore, exclusive emphasis is be placed on next-generation efficient bioinoculants having secondary metabolite formulations with longer shelf life and advanced competence against several phytopathogens. Valuable chapters deal with bioformulation strategies that use divergent groups of the microbiome and include detailed diagrammatic and pictorial representation. This book will be highly beneficial for both experts and novices in the fields of microbial bioformulation, nanotechnology, and nano-microbiotechnology. It discusses the prevailing status and applications available for microbial researcher s and scientists, agronomists, students, environmentalists, agriculturists, and agribusiness professionals, as well as to anyone devoted to sustaining the ecosystem.<br/>::Contents##<br/>Preface<br/>1. Application of novel bio-formulation of microbes for biocontrol agent<br/>2. Nano analysis of drugs and agrochemicals in environmental samples<br/>3. Stimuli responsive nanoparticles for drug delivery applications<br/>4. Green synthesis approaches of nanoagroparticles<br/>5. Herbonanoceutical: Novel beginning in drug discovery and therapeutics<br/>6. Functionalization of nanoparticles as microbial control<br/>7. Recent developments on antimicrobial nanocomposites for improving indoor air quality<br/>8. An insight into nano-biofertilizers for sustainable agriculture<br/>9. Nanotechnology: A successful approach to improve nutraceutical bioavailability<br/>10. Nano-based pesticides: challenges for pest Management<br/>11. Application of Nanotechnology in Plant Protection by Phytopathogens: Present and future prospects<br/>12. Nanotechnology in Nutraceuticals Delivery and Bioavailability<br/>13. Metallic nanoparticles and nanoformulations: as nanofungicides for sustainable disease management in plants<br/>14. Interaction of microorganisms with nanomaterials as a basis for creating high-efficiency biotechnological preparations<br/>15. Bio-based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Protection<br/>Index.

::Summary## This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.<br/>::Contents##<br/>Neurodegenerative Diseases: The Real Problem and Nanobiotechnological Solutions<br/>Nanotechnology at the Rescue of Neurodegenerative Diseases: Tools for Early Diagnostic<br/>The Role of Nanomedicine in treatment for Neurodegenerative disorders<br/>Nanobiotechnology in Neurodegenerative Diseases<br/>Application of Mycogenic Nanoparticles against Neurodegenerative diseases<br/>Nanotechnology-mediated nose to brain drug delivery for neurodegenerative disorders<br/>Nanobiotechnology in Parkinson's disease<br/>Selenium nanoparticles as therapeutic agents in Neurodegenerative diseases<br/>Role of Supermagnetic nanoparticles in Alzheimer, s disease<br/>Nanomedicines for improved antiretroviral therapy in Neuro-AIDS<br/>Nanocarrier mediated drug delivery systems for neurodegenerative diseases<br/>Gold nanoparticles in diagnosis and treatment of Alzheimer's disease<br/>Nano-Lipidic Carriers as Potential Drug Delivery Vehicles in Alzheimer's Disease<br/>Curcumin and its nanoformulations as therapeutic for Alzheimer's disease<br/>Nanopharmaceuticals for the Improved Treatment of Cerebral Stroke.

::Contents##<br/>High-aspect-ratio gold nanorods : their synthesis and application to image cell-induced strain fields in collagen films / Davin J. Chernak ... [et al.]<br/>Imaging intracellular quantum dots : fluorescence microscopy and transmission electron microscopy / Craig J. Szymanski ... [et al.]<br/>Imaging of cell populations in atherosclerosis using quantum dot nanocrystals / Joshua R. Trantum and Ashwath Jayagopal<br/>Imaging of endothelial progenitor cell subpopulations in angiogenesis using quantum dot nanocrystals / Joshua M. Barnett, John S. Penn, and Ashwath Jayagopal<br/>Imaging single synaptic vesicles in mammalian central synapses with quantum dots / Qi Zhang<br/>Quantum dot-based single-molecule microscopy for the study of protein dynamics / Jerry C. Chang and Sandra J. Rosenthal<br/>Three-dimensional molecular imaging with photothermal optical coherence tomography / Melissa C. Skala ... [et al.]<br/>Detecting respiratory syncytial virus using nanoparticle-amplified immuno-PCR / Jonas W. Perez ... [et al.]<br/>Gold nanoparticle-oligonucleotide conjugates for the profiling of malignant melanoma phenotypes / John W. Stone ... [et al.]<br/>Methods for isolating RNA sequences capable of binding to or mediating the formation of inorganic materials / Carly Jo Carter, Alina Owczarek, and Daniel L. Feldheim<br/>Single-walled carbon nanotube-mediated small interfering RNA delivery for gastrin-releasing peptide receptor silencing in human neuroblastoma / Jingbo Qiao ... [et al.]<br/>Amino acid mediated linear assembly of au nanomaterials / Manish Sethi and Marc R. Knecht<br/>Enzyme-gold nanoparticle bioconjugates : quantification of particle stoichiometry and enzyme specific activity / Jacqueline D. Keighron and Christine D. Keating<br/>In vivo testing for gold nanoparticle toxicity / Carrie A. Simpson, Brian J. Huffman, and David E. Cliffel<br/>Methods for studying toxicity of silica-based nanomaterials to Living Cells / Yang Zhao ... [et al.].

::Summary## This work synthesizes research and practical work, including various techniques and applications of botany and nanoparticles, including enzymology, pharmaceuticals, phenolics, antioxidants, metal particles, synthesis of nanoparticles by plants and microbes, and more. The text discusses the latest research as well as key sources of information condensed from other scholars across the globe, providing a comprehensive resource for scholars working in nanobotany, as well as chemists and researchers in the pharmaceutical industry.<br/>::Contents##<br/>Intro; Dedication; Preface; Contents; List of Figures; List of Plates; List of Tables; <br/>Chapter 1: Plants and Nanoworld: an Introduction; 1.1 Introduction; 1.2 Plant Metabolites; 1.3 Classes and Number of Secondary Metabolites; 1.4 Terpenoids; 1.4.1 Mono and Sesqui-terpenoids, and Phenylpropanoids; 1.4.2 Diterpenoids; 1.4.3 Functions; 1.4.4 Plant Families Rich in Terpenoids; 1.5 Alkaloids; 1.5.1 Families Rich in Alkaloids; 1.6 Phenolic Compounds; 1.6.1 Flavonoids; 1.6.2 Flavones; 1.6.2.1 Flavan-3-ols; 1.6.2.2 Isoflavones; 1.6.2.3 Plant Families Rich in Phenolic Compounds; 1.7 Tannins. 1.7.1 Plant Families Rich in Tannins1.8 Glycosides; 1.8.1 Categories of Glycosides; 1.8.2 Families Rich in Glycosides; 1.9 Conclusion; References; <br/>Chapter 2: Advanced Concept of Green Synthesis of Metallic Nanoparticles by Reducing Phytochemicals; 2.1 Introduction; 2.2 Role of Phytochemicals in Nanoparticles Synthesis; 2.3 Nanoparticles Synthesis from Plant Parts and Whole Plant; 2.4 Reproducibility of Nanoparticles; 2.5 Nanoparticles Synthesis from Phytochemicals/Plant Metabolites; 2.5.1 Nanoparticles Synthesis from Terpenoids; 2.5.2 Nanoparticles Synthesis from Flavonoids. 2.5.3 Nanoparticles Synthesis from Sugars2.5.4 Nanoparticles Synthesis from Proteins; 2.6 Mechanism of Metallic Nanoparticles Synthesis; 2.7 Potential Plants (Phytochemicals) for Synthesis of Nanoparticles; 2.8 Conclusion; 2.9 Future Prospects; References; <br/>Chapter 3: Classification of Green Nanoparticles; 3.1 Introduction; 3.2 Green Nanotechnology; 3.3 Plants and Green Nanotechnology; 3.4 Green Nanoparticles; 3.5 Nanoparticles Composition; 3.6 Basic Approaches for Nanoparticles Synthesis; 3.7 Methods for the Green Synthesis of Nanoparticles; 3.7.1 Chemical Synthesis of Nanoparticles. 3.8 Types of Nanoparticles3.9 Benefits of Green Synthesis Over the Chemical Synthesis; 3.10 Gold Nanoparticles; 3.11 Silver Nanoparticles; 3.12 Copper Nanoparticles; 3.13 Iron Nanoparticles; 3.14 Palladium Nanoparticles; 3.15 Platinum Nanoparticles; 3.16 Selenium Nanoparticles; 3.17 Titanium Nanoparticles; 3.18 Zinc Oxide Nanoparticles; 3.19 Applications of Green Nanoparticles; 3.20 Conclusion; References; <br/>Chapter 4: Nanofibers and Nanowires; 4.1 Fundamentals of Nanomaterials; 4.2 Introduction to Nano Fibers and Nanowires; 4.3 One-Dimensional Nanomaterials; 4.4 Types of Nanowires. 4.5 Properties of Nanofibers and Nanowires4.5.1 Mechanical Properties; 4.5.2 Optical Properties; 4.5.3 Electrical Properties; 4.6 Nano Fibers and Nanowires Synthesis Techniques; 4.6.1 Template Based Growth; 4.6.2 Phase Separation; 4.6.3 Self-Assembly; 4.6.4 Electrospinning; 4.6.5 Template-Free (Interfacial Polymerization); 4.6.6 Vapor-Liquid-Solid (VLS) Growth; 4.6.7 Hydrothermal Synthesis; 4.6.8 Sol-Gel Synthesis; 4.7 Applications of Nanofibers; 4.7.1 Carbon Nanotubes; 4.7.2 Difference in Carbon Nanotubes and Nanofibers; 4.7.3 Biological and Chemical Application of Nanofibers/Wires.

::Contents##<br/>1. Electroanalysis with carbon film-based electrodes<br/>2. Carbon nanofibers for electroanalysis<br/>3. Carbon nanomaterials for neuroanalytical chemistry<br/>4. Carbon and graphene dots for electrochemical sensing<br/>5. Electroanalytical applications of graphene<br/>6. Graphene/gold nanoparticles for electrochemical sensing<br/>7. Recent advances in electrochemical biosensors based on Fullerene-C60 nano-structured platforms<br/>8. Micro- and nano-structured diamond in electrochemistry: fabrication and application<br/>9. Electroanalysis with C₃N₄ and SiC nanostructures.

::Summary## This first book on nanocellulose and nanohydrogels for biomedical applications is unique in discussing recent advancements in the field, resulting in a comprehensive, well-structured overview of nanocellulose and nanohydrogel materials based nanocomposites. The book covers different types of nanocellulose materials and their recent developments in the drug delivery and nanomedicine sector, along with synthesis, characterization, as well as applications in the biotechnological and biomedical fields. The book also covers the current status and future perspectives of bacterial cellulose and polyester hydrogel matrices, their preparation, characterization, and tissue engineering applications of water soluble hydrogel matrices obtained from biodegradable sources. In addition, the chitosan-based hydrogel and nanogel matrices, their involvement in the current biofabrication technologies, and influencing factors towards the biomedical sector of biosensors, biopharmaceuticals, tissue engineering appliances, implant materials, diagnostic probes and surgical aids are very well documented. Further, the history of cellulose-based and conducting polymer-based nanohydrogels, their classification, synthesis methods and applicability to different sectors, the challenges associated with their use, recent advances on the inhibitors of apoptosis proteins are also included. The recent developments and applications in the drug delivery sector gives an overview of facts about the nanofibrillated cellulose and copoly(amino acid) hydrogel matrices in the biotechnology and biomedicine field. This book serves as an essential reference for researchers and academics in chemistry, pharmacy, microbiology, materials science and biomedical engineering.<br/>::Contents##<br/>Application of Nanocellulose for Controlled Drug Delivery / Lalduhsanga Pachuau<br/>Bacterial Cellulose and Polyester Hydrogel Matrices in Biotechnology and Biomedicine: Current Status and Future Prospects / Rajnikant Borkar, Sanghratna S Waghmare, Tanvir Arfin<br/>Bacterial Nanocellulose Applications for Tissue Engineering / Muhammed Lamin Sanyang, Naheed Saba, Mohammad Jawaid, Faruq Mohammad, Mohd Sapuan Salit<br/>Cellulose-Based Nanohydrogels for Tissue Engineering Applications / Kalyani Prusty, Sarat K Swain<br/>Chitosan-Mediated Layer-by-Layer Assembling Approach for the Fabrication of Biomedical Probes and Advancement of Nanomedicine / Faruq Mohammad, Hamad A Al-Lohedan<br/>Hydrogels Based on Nanocellulose and Chitosan: Preparation, Characterization, and Properties / Meriem Fardioui, Abou Qaiss, Rachid Bouhfid<br/>Cellulose Nanocrystals and PEO/PET Hydrogel Material in Biotechnology and Biomedicine: Current Status and Future Prospects / Shoeb Athar, Rani Bushra, Tanvir Arfin<br/>Conducting Polymer Hydrogels: Synthesis, Properties, and Applications for Biosensors / Yu Zhao<br/>Nanocellulose and Nanogels as Modern Drug Delivery Systems / Misu Moscovici1, Cristina Hlevca2, Angela Casarica1, Ramona-Daniela Pavaloiu2<br/>Recent Advances on Inhibitors of Apoptosis Proteins (IAP) Particularly with Reference to Patents / Riyaz Syed, Prema L Mallipeddi, Syed Mohammed Ali Hussaini, Rahul V Patel, A Prasanth Saraswati, Ahmed Kamal<br/>Nanohydrogels: History, Development, and Applications in Drug Delivery / Muhammad Akram, Rafaqat Hussain<br/>Nanofibrillated Cellulose and Copoly(amino acid) Hydrogel Matrices in Biotechnology and Biomedicine / Azhar U Khan, Nazia Malik, Tanvir Arfin.

::Contents##<br/>Fundamentals on Nanoelectronics. A Brief History of the Semiconductor Industry / Paolo A Gargini<br/>More-than-Moore Technologies and Applications / Joachim Pelka, Livio Baldi<br/>Logic Devices Challenges and Opportunities in the Nano Era / Frédéric Boeuf<br/>Memory Technologies / Barbara De Salvo, Livio Baldi<br/>Devices in the Nano Era. Beyond-CMOS Low-Power Devices: Steep-Slope Switches for Computation and Sensing / Adrian M Ionescu<br/>RF CMOS / Patrick Reynaert, Wouter Steyaert, Marco Vigilante<br/>Smart Power Devices Nanotechnology / Gaudenzio Meneghesso, Peter Moens, Mikael Östling, Jan Sonsky, Steve Stoffels<br/>Integrated Sensors and Actuators: Their Nano-Enabled Evolution into the Twenty-First Century / Frederik Ceyssens, Robert Puers<br/>Advanced Materials and Materials Combinations. Silicon Wafers as a Foundation for Growth / Peter Stallhofer<br/>Nanoanalysis / Narciso Gambacorti<br/>Semiconductor Smart Manufacturing. Front-End Processes / Marcello Mariani, Nicolas Possémé<br/>Lithography for Nanoelectronics / Kurt Ronse<br/>Reliability of Nanoelectronic Devices / Anthony S Oates, KP Cheung<br/>Circuit Design in Emerging Nanotechnologies. Logic Synthesis of CMOS Circuits and Beyond / Enrico Macii, Andrea Calimera, Alberto Macii, Massimo Poncino<br/>System Design in the Cyber-Physical Era / Pierluigi Nuzzo, Alberto Sangiovanni-Vincentelli<br/>Heterogeneous Systems / Daniel Lapadatu<br/>Nanotechnologies Testing / Ernesto Sanchez, Matteo Sonza Reorda<br/>Nanoelectronics-Enabled Sectors and Societal Challenges. Industrial Applications / L Baldi, M Van de Voorde<br/>Health / Walter De Raedt, Chris Van Hoof<br/>Smart Energy / Moritz Loske<br/>Validation of Highly Automated Safe and Secure Vehicles / Michael Paulweber<br/>Nanotechnology for Consumer Electronics / Hannah M Gramling, Michail E Kiziroglou, Eric M Yeatman<br/>From Device to Systems. Nanoelectronics for Smart Cities / Joachim Pelka<br/>Industrialization: Economics/Markets<br/>Business Values<br/>European Visions<br/>Technology Renewal and Extended Functionality. Europe Positioning in Nanoelectronics / Andreas Wild<br/>Thirty Years of Cooperative Research and Innovation in Europe: The Case for Micro- and Nanoelectronics and Smart Systems Integration / Dirk Beernaert, Eric Fribourg-Blanc<br/>The Education Challenge in Nanoelectronics / Susanna M Thon, Sean L Evans, Annastasiah Mudiwa Mhaka<br/>Conclusions / Robert Puers, Livio Baldi, Marcel Van de Voorde.

::Summary## This book assesses the current challenges and opportunities for the next generation of agriculture and food science. Examining the role of nanotechnology and the application of related tools and techniques to transform the future of food, it also discusses in detail nanotechnology in food production, processing and packaging, as well as the benefits of and concerns regarding nanofoods (nanotoxicity and food forensics). Considering the potential of IoT to revolutionize agriculture and the food industry by radically reducing costs and improving productivity and profits, the book highlights the necessity of integrating IoT and nanotechnology into the next generation of agriculture and food science. Further, it presents a detailed analysis of IoNT implementation, together with the goals that have to be met in order to achieve significant improvements in the agri-food sector. In addition it explores a range of challenges, risks, and concerns that have a direct or indirect impact on nanotechnology and IoNT implementation in agriculture and the food industry. In closing, it discusses the use of green nanotechnology and green IoNT in order to create smart, safe, and sustainable agriculture and healthy food.<br/>::Contents##<br/>Intro; Preface; Contents; Abbreviations; 1 What Food Do We Want to Eat? Is Nanofood Food of Our Future?; References; 2 How Technology Can Help?; 2.1 Wireless Sensor Network (WSN); 2.2 Internet of Things (IoT); 2.3 Nanotechnology; 2.3.1 Internet of Nano Things (IoNT); 2.4 The Role of Nanotechnology and IoNT in Agriculture and Food Sector; 2.4.1 Nanofood; 2.4.2 Plant Production and Protection; 2.4.3 Animal Production; 2.4.4 Food Processing; 2.4.5 Food Packaging; 2.4.6 Food Transportation; 2.4.7 Food Traceability; References; 3 Is Nanofood Safe?; 3.1 Food Forensic 3.1.1 Historical Development of Food Adulteration3.1.2 Food Fraud; 3.1.3 Methods Used in Food Forensics; 3.2 Nanotoxicology; 3.2.1 Environmental Related Nano-Hazards; 3.2.2 Human Health-Related Nano-Hazards; 3.2.3 Risk Assessment and Risk Management; 3.3 Regulatory Issues of Nanotechnology Use in the Agri-Food Industry; 3.3.1 Challenges for Regulating Nanotechnology Utilization in Agriculture and Food Sector; 3.4 Risks and Challenges of IoNT Applications in Agriculture and Food Industry; References; 4 Solution?; 4.1 Green Nanotechnology; 4.1.1 Green Synthesis of Nanomaterials 4.1.2 The Applications of Green Synthesized Nanomaterials4.1.3 Risk Assessment and Risk Management; 4.1.4 Regulatory Issues; 4.2 Green IoNT; 4.3 Solutions for IoNT Risks; References; 5 Conclusion

::Contents##<br/>Introduction : nanoimaging techniques in biology / Alioscka A. Sousa and Michael J. Kruhlak<br/>Live-cell imaging of vesicle trafficking and divalent metal ions by total internal reflection fluorescence (TIRF) microscopy / Merewyn K. Loder, Takashi Tsuboi, and Guy A. Rutter<br/>4Pi microscopy / Roman Schmidt, Johann Engelhardt, and Marion Lang<br/>Fluorescence in situ hybridization applications for super-resolution 3D structured illumination microscopy / Yolanda Markaki [and others]<br/>Two-color STED imaging of synapses in living brain slices / Jan Tonnesen and U. Valentin Nagerl<br/>Super-resolution imaging by localization microscopy / Dylan M. Owen [and others]<br/>High-content super-resolution imaging of live cell by uPAINT / Gregory Giannone [and others]<br/>Super-resolution fluorescence imaging with blink microscopy / Christian Steinhauer, Michelle S. Itano, and Philip Tinnefeld<br/>Photoswitchable fluorophores for single-molecule localization microscopy / Kieran Finan, Benjamin Flottmann, and Mike Heilemann<br/>Single-molecule tracking of mRNA in living cells / Mai Yamagishi, Yoshitaka Shirasaki, and Takashi Funatsu<br/>Semiautomatic, high-throughput, high-resolution protocol for three-dimensional reconstruction of single particles in electron microscopy / Carlos Oscar Sorzano [and others]<br/>Mass mapping of amyloid fibrils in the electron microscope using STEM imaging / Alioscka A. Sousa and Richard D. Leapman<br/>Elemental mapping by electron energy loss spectroscopy in biology / Maria A. Aronova and Richard D. Leapman<br/>Cellular nanoimaging by cryo electron tomography / Roman I. Koning and Abraham J. Koster<br/>Large-volume reconstruction of brain tissue from high-resolution serial section images acquired by SEM-based scanning transmission electron microscopy / Masaaki Kuwajima, John M. Mendenhall, and Kristen M. Harris<br/>3D imaging of cells and tissues by focused ion beam/ scanning electron microscopy (FIB/SEM) / Damjana Drobne<br/>Preparation of gold nanocluster bioconjugates for electron microscopy / Christine L. Heinecke and Christopher J. Ackerson<br/>Atomic force microscopy imaging of macromolecular complexes / Sergio Santos, Daniel Billingsley, and Neil Thomson<br/>Imaging of transmembrane proteins directly incorporated within supported lipid bilayers using atomic force microscopy / Daniel Levy and Pierre-Emmanuel Milhiet<br/>Functional AFM imaging of cellular membranes using functionalized tips / Lilia A. Chtcheglova and Peter Hinterdorfer<br/>Near-field scanning optical microscopy for high-resolution membrane studies / Heath A. Huckabay [and others]<br/>Correlative fluorescence and EFTEM imaging of the organized components of the mammalian nucleus / Michael J. Kruhlak<br/>High data output method for 3-D correlative light-electron microscopy using ultrathin cryosections / Katia Cortese [and others]<br/>Correlative optical and scanning probe microscopies for mapping interactions at membranes / Christopher M. Yip<br/>Nanoimaging cells using soft x-ray tomography / Dilworth Y. Parkinson [and others]<br/>Secondary ion mass spectrometry imaging of biological membranes at high spatial resolution / Haley A. Klitzing, Peter K. Weber, and Mary L. Kraft.

::Contents##<br/>Presence in, and release of, nanomaterials from consumer products / Yu Yang and Paul Westerhoff<br/>Nanoparticle aggregation: principles and modeling / Wen Zhang<br/>Influences of nanomaterials on the barrier function of epithelial cells / Shariq Ali and Erik Rytting<br/>Engineered nanoparticles induced brush border disruption in a human model of the intestinal epithelium / James J. Faust, Benjamin M. Masserano, Adam H. Mielke, Anup Abraham, and David G. Capco<br/>Nanoparticles: cellular uptake and cytotoxicity / Isaac M. Adjei, Blanka Sharma and Vinod Labhasetwar<br/>Atomic force microscopy study of the interaction of DNA and nanoparticles / Kungang LI, Songyan Du, Steven Van Ginkel, and Yongsheng Chen<br/>Intracellular signal modulation by nanomaterials / Salik Hussain, Stavros Garantziotis, Fernando Rodrigues-Lima, Jean-Marie Dupret, Armelle Baeza-Squiban, Sonja Boland<br/>Nanomaterials: impacts on cells and cell organelles / Željka Krpetić, Sergio Anguissola, David Garry, Philip Kelly and Kenneth A. Dawson<br/>Design, synthesis, and functionalization of nanoparticles for therapeutic drug delivery / Taraka Sai Pavan Grandhi and Kaushal Rege<br/>Preparation of nanoscale pulmonary drug delivery formulations by spray drying / Adam Bohr, Christian A. Ruge, and Moritz Beck-Broichsitter<br/>Nanomedicine: the promise and challenges in cancer chemotherapy / Youssef W. Naguib and Zhengrong Cui<br/>Transgenerational effects of NMs / Anna Poma, Sabrina Colafarina, Gabriella Fontecchio, and Giuseppe Chichiricco<br/>Stem cells and nanomaterials / Maria-Claude Hofmann.

::Summary## This book comprehensively reviews the recent advances in nanomaterial-based molecular imaging, diagnostics, and personalized therapy. It discusses the novel biocompatible fluorescent nanomaterials, their synthesis, and modern state of art characterization, as well as the various strategies for immobilization of biomacromolecules on the nanomaterial surface and approaches for increasing their stability. In addition, the book describes the synthesis of lectin nanoconjugates using different types of biocompatible raw materials and their systematic characterization. Lastly, it presents our current understanding of the biomolecular carona, which affects nanoparticle-based targeted drug delivery, and examines the conceptual approaches to improve the in-vivo efficacy of targeted drug delivery.<br/>::Contents##<br/>Chapter 1. Nanomaterials: From research to personalized medicine<br/>Chapter 2. Introduction to molecular imaging, diagnostics and therapy<br/>Chapter 3. Biocompatible fluorescent nanomaterials for molecular imaging applications<br/>Chapter 4. Nanomaterials for Point of Care Disease Detection<br/>Chapter 5. Biomolecules immobilized nanomaterials and their biological applications<br/>Chapter 6. Lectin nanoconjugates for targeted therapeutic applications<br/>Chapter 7. Plant Based Polymeric Nanomaterials for Biomedical Applications<br/>Chapter 8. Nanomaterials at the biological interphase: Protein corona formation and infusion<br/>Chapter 9. Critical overview of the subject: Current scenario and future prospects.

::Summary## The range of nanomaterial applications has expanded recently from catalysis, electronics, and filtration to therapeutics, diagnostics, agriculture, and food because of the unique properties and potentials of different nanoparticles and nanomaterials. Research shows that these exquisite particles can interact with an organism at the cellular, physiological, biochemical, and molecular levels. Our knowledge, however, of how they affect these changes, selectively or generally, in diverse organisms or ecosystems is very limited and far from satisfactory. Data indicate that the biological function largely depends on the shape, size, and surface characteristics of the nanoparticles used along with life cycle stages of an organism. This book focuses on the body of work carried out by distinguished investigators using diverse nanomaterials in both plant and animal species. It includes specific case studies as well as general reviews highlighting aspects of multilayered interactions. This volume provides a comprehensive resource for academic scholars, as well as for researchers in the concerned industries and policy makers.<br/>::Contents##<br/>Application of Titanium Dioxide Nanoparticles in Consumer Products Raises Human Health Concerns: Lessons from Murine Models of Toxicity<br/>Zebrafish Models of Nanotoxicity: A Comprehensive Account<br/> Caenorhabditis elegans: A Unique Animal Model to Study Soil-Nanoparticles-Organism Interactions<br/>Response to Engineered Nanomaterials in Arabidopsis thaliana, a Model Plant<br/>Metal Oxide Nanoparticle Toxicity in Aquatic Organisms: An Overview of Methods and Mechanisms<br/>Responses of Terrestrial Plants to Metallic Nanomaterial Exposure: Mechanistic Insights, Emerging Technologies, and New Research Avenues<br/>Cerium and Titanium Oxide Nanoparticles Increase Algal Growth and Nutrient Accumulation in Rice Paddy Environments<br/>Application of Metal Oxide Nanomaterials in Agriculture: Benefit or Bane?<br/>The Role of Zinc Oxide Nanoparticles in Plants: A Critical Appraisal<br/>Fate and Effects of Engineered Nanomaterials in Agricultural Systems<br/>Interaction of Food-Grade Nanotitania with Human and Mammalian Cell Lines Derived from GI Tract, Liver, Kidney, Lung, Brain, and Heart<br/>Green Engineering of Silver Nanoparticles Using Leucas aspera Extract: Cytotoxic Efficacy in HeLa Cell Line<br/>Nanoparticles-Mediated Interventions to Prevent Herpes Simplex Virus (HSV) Entry into Susceptible Hosts<br/>Nanoparticle Biosynthesis and Interaction with the Microbial Cell, Antimicrobial and Antibiofilm Effects, and Environmental Impact<br/>The Chemistry behind Nanotoxicological Processes in Living Systems<br/>Nanomaterial Interaction and Cellular Damage: Involvement of Various Signalling Pathways.

::Contents##<br/>Preparation of 2 nm gold nanoparticles for in vitro and in vivo applications / Daniel F. Moyano, Bradley Duncan, and Vincent M. Rotello<br/>DNA conjugation to nanoparticles / Sunho Park<br/>Conjugation of nanoparticles to proteins / Marie-Eve Aubin-Tam<br/>Water-solubilization and functionalization of semiconductor quantum dots / Christina M. Tyrakowski, Adela Isovic, and Preston T. Snee<br/>Synthesizing and modifying peptides for chemoselective ligation and assembly into quantum dot-peptide bioconjugates / W. Russ Algar ... [et al.]<br/>Reliable methods for silica coating of au nanoparticles / Isabel Pastoriza-Santos and Luis M. Liz-Marzán<br/>Surface modifications by polymers for biomolecule conjugation / Laura Sola ... [et al.]<br/>Functionalization protocols of silicon micro/nano- mechanical biosensors / Francesca Frascella and Carlo Ricciardi<br/>Stability and aggregation assays of nanoparticles in biological media / James Chen Yong Kah<br/>Electrochemical measurements of DNA melting on surfaces / Irina Belozerova, Dongbiao Ge, and Rastislav Levicky<br/>Formation and characterization of the nanoparticle-protein corona / Marco P. Monopoli ... [et al.]<br/>Electrophoretic implementation of the solution-depletion method for measuring protein adsorption, adsorption kinetics, and adsorption competition among multiple proteins in solution / Hyeran Noh ... [et al.]<br/>Hyperspectral microscopy for characterization of gold nanoparticles in biological media and cells for toxicity assessment / Christin Grabinski, John Schlager, and Saber Hussain<br/>Immunocytochemistry, electron tomography, and energy dispersive x-ray spectroscopy (EDXS) on cryosections of human cancer cells doped with stimuli responsive polymeric nanogels loaded with iron oxide nanoparticles / Roberto Marotta ... [et al.]<br/>Zwitterion siloxane to passivate silica against nonspecific protein adsorption / Zaki G. Estephan and Joseph B. Schlenoff<br/>Preparation and characterization of DNA block copolymer assemblies loaded with nanoparticles / Xi-Jun Chen, Robert J. Hickey, and So-Jung Park<br/>Polyaspartic acid coated iron oxide nanoprobes for PET/MRI imaging / Taku Cowger and Jin Xie<br/>Ligand synthesis and passivation for silver and large gold nanoparticles for single-particle-based sensing and spectroscopy / Daniel Montiel ... [et al.]<br/>Noncovalent intracellular drug delivery of hydrophobic drugs on au NPs / Tennyson Doane and Clemens Burda<br/>Modification of carbon nanotubes for gene delivery vectors / Victor Ramos-Perez ... [et al.]<br/>Lipid-based nanoparticles as nonviral gene delivery vectors / Daniele Pezzoli ... [et al.]<br/>Stabilizing gold nanoparticle bioconjugates in physiological conditions by PEGylation / Joan Comenge and Víctor F. Puntes.

::Summary## The environment is prone to suffer pollution and toxic insult from generations of nanomaterials as well from accidental releases during production, transportation, and disposal operations. The NMs could interact with and cause adverse biological effects at cellular, subcellular, and molecular levels. Assessing potential environmental/ecological risks requires quality information on transport and fate of nanoparticles in the environment, exposures and vulnerabilities of organisms to the nanomaterials and standard methods for assessing toxicity for aquatic or terrestrial organisms and human health. The systematic risk characterization and evaluation of the safety of nanomaterials require a multidisciplinary approach and convergence of knowledge and efforts from researchers and experts from toxicology, biotechnology, materials science, chemistry, physics, engineering, and other branches of life sciences. Although studies are beginning to appear in the literature addressing the toxicity of various nanomaterials and their potential for exposure, at this stage definitive statements regarding the impacts of nanomaterials on human health and the environment remain sketchy requiring an increased level of precautions with regard to nanomaterials, as has happened with other emerging contaminants and technologies (e.g., biotechnology). The need for an increased level of understanding the perception of risk and of benefits will vary and is likely to influence public, regulatory, and non-governmental activities regarding risk and benefit evaluations. Systematic identification and assessment of the risks posed by any new technology are essential. A prudent, integrated, and holistic approach is required to develop best practices based on the scientific understanding about what we know and what we don?t know but need to know. Nanomaterials addresses key issues of ecotoxicological actions and effects of nanomaterials on life and environment, their threats, vulnerability, risks, and public perception. The readers learn to read bad news objectively and think about and search for ecological?green? solutions to current environmental and ecological problems with blue, grey, brown, and red shades for building a sustainable ecosystem. It shows how this molecular terrain is a common ground for interdisciplinary research and education that will be an essential component of science, engineering and technology in the future. The book is divided into three sections. Section I includes general topics related to ecotoxicity of nanomaterials to microbes, plants, human and environment. Section 2 incorporates risks generated by the use of nanomaterials. Section 3 discusss safety issues and the public.<br/>::Contents##<br/>PART 1-GENERAL Ecotoxicology Issues with Nanomaterials<br/>Nanomaterials: What are they, why they cause ecotoxicity, and how this can be dealt with?<br/>Nano-bio interactions and ecotoxicity: Plenty of room at the bottom but tyranny at the top<br/>Chemical Structure and toxicity of Nanomaterials used in Food and Food Products<br/>Toxicity and Safety Evaluation of Nanoclays<br/>Toxicity of nanoparticles on soil mycoflora<br/>Ecotoxicity of nanometals: The problems and solutions<br/>Electrochemical assessment of the interaction and toxicity of carbon nanomaterials on microbial living cells<br/>Nanotoxicity in Plant Systems<br/>Nanotoxicity of lipid based nanomedicines<br/>Toxicity of Silver and zinc Nanoparticles in an aquatic environment<br/>PART 2-RISKS<br/>Carbon nanomaterials<br/>Potential risks to human health and the environment<br/>Nanoparticles emitted by biomass burning: Characterization and monitoring of risk<br/>Unintentionally produced nanomaterials and different aspects related to their risks<br/>PART 3 SAFETY ISSUES AND PUBLIC PERCEPTION<br/>Nanotechnological regulations in Brazil<br/>Nanohazards and safety challenges<br/>Regulatory Framework for Nano-materials in Agri-Food Systems.

::Summary## Nanotechnology is considered as one of the emerging fields of science. It has applications in different biological and technological fields which deal with the science of materials at nanoscale (10-9). On the other hand, biotechnology is another field that deals with contemporary challenges. Nanobiotechnology fills the gap between these two fields. It merges physical, chemical, and biological principles in a single realm. This combination opens up new possibilities. At nanoscale dimensions, it creates precise nanocrystals and nanoshells. Integrated nanomaterials are used with modified surface layers for compatibility with living systems, improved dissolution in water, or biorecognition leading to enhanced end results in biotechnological systems. These nanoparticles can also be hybridized with additional biocompatible substances in order to amend their qualities to inculcate novel utilities. Nanobiotechnology is used in bioconjugate chemistry by coalescing up the functionality of non-organically obtained molecular components and biological molecules in order to veil the immunogenic moieties for targeted drug delivery, bioimaging and biosensing. This book blends the science of biology, medicine, bioinorganic chemistry, bioorganic chemistry, material and physical sciences, biomedical engineering, electrical, mechanical, and chemical science to present a comprehensive range of advancements. The development of nano-based materials has made for a greater understanding of their characterization, using techniques such as transmission electron microscope, FTIR, X-ray diffraction, scanning electron microscope EDX, and so on. This volume also highlights uses in environmental remediation, environmental biosensors and environmental protection. It also emphasizes the significance of nanobiotechnology to a series of medical applications viz., diagnostics, and therapeutics stem cell technology, tissue engineering enzyme engineering, drug development and delivery. In addition this book also offers a distinctive understanding of nanobiotechnology from researchers and educators and gives a comprehensive facility for future developments and current applications of nanobiotechnology.<br/>::Contents##<br/>Preface<br/>Nanoparticles and Plant Interaction with Respect to Stress Response<br/>Nanoencapsulation technology: Boon to food packaging industries<br/>Ecotoxicity of Metallic Nanoparticles and Possible Strategies for Risk Assessment<br/>Tripartite Interaction among Nanoparticles, Symbiotic Microbes and Plants; Current Scenario and Future Perspectives<br/>Effect of nanoparticles on plant growth and physiology and soil microbes<br/>Recent Trends and Advancement towards Phyto-Mediated Fabrication of Noble Metallic Nanomaterials: Focus on Silver, Gold, Platinum and Palladium<br/>Development of environmental biosensors for detection, monitoring and assessment<br/>Nano-based materials and their synthesis<br/>Nano based composites and their synthesis<br/>Appraisal of chitosan-based nanomaterials in enzyme immobilization and probiotics encapsulation<br/>Nano based drug delivery tools for personalized nanomedicine<br/>Nano-technology as Potential and Innovative Platform towards Waste Water Treatment: An Overview<br/>Solid lipid nanoparticles<br/>Nanotechnology Applications and Synthesis of Graphene as nanomaterial for nanoelectronics<br/>Efficiency enhancement of renewable energy systems using nanotechnology<br/>Waste Water and Industrial Effluent Treatment by using Nanotechnology<br/>Biomolecular and cellular manipulation and detection (Nanofluidics, Micro- and Nanotechnologies in Integrative Biology)<br/>Bio-based Nano-lubricants for Sustainable Manufacturing<br/>Nano materials used for delivery of bioactive<br/>Efficacy of nano-phytochemicals over pure phytochemicals against various cancers: Current trends and future prospects<br/>Index.

::Summary## This book discusses the latest developments in plant-mediated fabrication of metal and metal-oxide nanoparticles, and their characterization by using a variety of modern techniques. It explores in detail the application of nanoparticles in drug delivery, cancer treatment, catalysis, and as antimicrobial agent, antioxidant and the promoter of plant production and protection. Application of these nanoparticles in plant systems has started only recently and information is still scanty about their possible effects on plant growth and development. Accumulation and translocation of nanoparticles in plants, and the consequent growth response and stress modulation are not well understood. Plants exposed to these particles exhibit both positive and negative effects, depending on the concentration, size, and shape of the nanoparticles. The impact on plant growth and yield is often positive at lower concentrations and negative at higher ones. Exposure to some nanoparticles may improve the free-radical scavenging potential and antioxidant enzymatic activities in plants and alter the micro-RNAs expression that regulate the different morphological, physiological and metabolic processes in plant system, leading to improved plant growth and yields. The nanoparticles also carry out genetic reforms by efficient transfer of DNA or complete plastid genome into the respective plant genome due to their miniscule size and improved site-specific penetration. Moreover, controlled application of nanomaterials in the form of nanofertilizer offers a more synchronized nutrient fluidity with the uptake by the plant exposed, ensuring an increased nutrient availability. This book addresses these issues and many more. It covers fabrication of different/specific nanomaterials and their wide-range application in agriculture sector, encompassing the controlled release of nutrients, nutrient-use efficiency, genetic exchange, production of secondary metabolites, defence mechanisms, and the growth and productivity of plants exposed to different manufactured nanomaterials. The role of nanofertilizers and nano-biosensors for improving plant production and protection and the possible toxicities caused by certain nanomaterials, the aspects that are little explored by now, have also been generously elucidated.<br/>::Contents##<br/>Intro; Preface; Contents; Part I: Plant-Mediated Synthesis and Applications of Nanomaterials; <br/>Chapter 1: Nanomaterials and Plant Potential: An Overview; 1.1 Introduction; 1.2 Type of Engineered NMs; 1.3 Characterization Techniques; 1.4 Physical and Chemical Characters of NMs; 1.5 Application and Impact of NMs; 1.6 Conclusion; References; <br/>Chapter 2: Basic Chemistry and Biomedical Significance of Nanomaterials; 2.1 Introduction; 2.2 Importance of Nanoscale; 2.3 Nanochemistry; 2.3.1 Quantum Confinement; 2.3.2 Surface Plasmon Resonance (SPR); 2.3.3 Nanoparticle Size Effects 2.3.4 Size Distribution of Nanostructures2.3.5 Shape of Nanoparticles; 2.3.6 Agglomeration of Nanoparticles; 2.3.7 Effect of pH, Ionic Strength, and Temperature on Agglomeration; 2.3.8 Solubility and Phase Transition of Nanoparticles; 2.4 Nanomaterials in Bio-systems; 2.4.1 Micelles and Liposomes; 2.4.2 Microemulsions; 2.4.3 Other Relevant Materials; 2.5 Preparation of Nanostructures for Use in Medicine; 2.5.1 Emulsion-Solvent Evaporation Method; 2.5.2 Double Emulsion and Evaporation Method; 2.5.3 Salting-Out Method; 2.5.4 Emulsion-Diffusion Method 2.5.5 Solvent Displacement/Precipitation Method2.6 Nanoencapsulation and Nanoencapsulated Materials; 2.7 Medical Significance of Nanostructures; 2.8 Conclusion; References; <br/>Chapter 3: Plant-Mediated Fabrication of Gold Nanoparticles and Their Applications; 3.1 Introduction; 3.2 Fabrication and Characterization of Gold Nanoparticles; 3.2.1 Fabrication of Gold Nanoparticles; 3.2.2 Characterization of Gold Nanoparticles; 3.2.2.1 Ultraviolet-Visible (UV-Vis) Spectroscopy; 3.2.2.2 Microscopy; 3.2.2.3 X-Ray Diffraction (XRD); 3.2.2.4 Dynamic Light Scattering (DLS) and Zeta Potential Analysis 3.2.2.5 Fourier Transform Infrared Spectroscopy (FTIR)3.3 Factors Affecting the Fabrication; 3.3.1 Temperature; 3.3.2 pH; 3.3.3 Incubation Time; 3.3.4 Plant Biomass Concentration; 3.4 Applications of Gold Nanoparticles; 3.4.1 Antimicrobial Agents; 3.4.2 Catalytic Activity and Water Purification; 3.4.3 Antioxidant Potential; 3.4.4 Photochemical Agents; 3.4.5 Plant Response to Gold Nanoparticles; 3.4.6 Biomedical Application; 3.5 Conclusion; References; <br/>Chapter 4: Green Synthesis of Gold Nanoparticles by Using Natural Gums; 4.1 Introduction; 4.2 Description of Various Gums 4.3 Synthesis of AuNPs4.3.1 Reaction Mechanism; 4.4 Characterization of AuNPs; 4.4.1 EDX Analysis; 4.4.2 Dynamic Light Scattering (DLS); 4.4.3 XRD Analysis; 4.5 Applications; 4.6 Conclusion; References; <br/>Chapter 5: Plant-Based Fabrication of Silver Nanoparticles and Their Application; 5.1 Introduction; 5.2 Fabrication and Characterization of Ag NPs; 5.3 Factors Affecting Fabrication of Ag NPs; 5.3.1 Temperature; 5.3.2 pH; 5.3.3 Incubation Time; 5.3.4 Plant Biomass Concentration; 5.4 Applications of Ag NPs; 5.4.1 Antimicrobial; 5.4.2 Biomedical Application

::Summary## As renewable energy sources, biofuels have tremendous potential to replace fossil fuels in future energy scenarios, offering green alternative energy sources. However, though such fuels could mean a significant reduction in environmental pollution, they are still far from practical implementation due to their high production costs and technical issues. Consequently, efforts are being made around the globe to achieve the cost-effective production of biofuels. In this context, the use of nanomaterials to improve biofuels production efficiency is a vital, emerging area. Nanomaterials are attracting attention due to their versatile physicochemical properties and may improve the production process for various biofuels by acting as catalysts. However, this area is still in its infancy. To improve the practical viability of the biofuels production process, it is essential to focus on the specific type of nanomaterial used, its synthesis, and its specific effects on the process parameters. This book explores the potential advantages and feasibility of various aspects of nanomaterials with regard to improving the current biofuels production process, making it a valuable resource for a broad readership.<br/>::Contents##<br/>Chapter 1. Biofuel; types and process overview<br/>Chapter 2. Applications of plant based natural products to synthesize nanomaterial-Part-i<br/>Chapter 3. Application of plant based natural product to synthesize nanomaterial-Part-2<br/>Chapter 4. Green synthesis approach to fabricate nanomaterials<br/>Chapter 5. Nanomaterials; types, synthesis and characterization<br/>Chapter 6. Nanotechnology: an application in biofuel production nanomaterial synthesis and mechanism for enzyme immobilization-part-i<br/>Chapter 7. Nanomaterial synthesis and mechanism for enzyme immobilization-part-ii<br/>Chapter 8. Nanomaterial synthesis and mechanism for enzyme immobilization-part-ii<br/>Chapter 9. Nanomaterials immobilized biocatalysts for biofuel production from lignocellulose biomass<br/>Chapter 10. Carbon nanotubes synthesized by green/ecofriendly technique potential for bioenergy applications<br/>Chapter 11. Synthesis of iron oxide nanomaterials for biofuels applications.

::Contents##<br/>Part I: Biomedical nanomaterials<br/>Nanoemulsions : preparation, stability and application in biosciences / Thomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer [and others]<br/>Multifunctional polymeric nanostructures for therapy and diagnosis / Angel Contreras-García, Emilio Bucio<br/>Carbon nanotubes : nanotoxicity testing and bioapplications / R. Sharma, S. Kwon<br/>Part II: Advanced nanomedicine<br/>Discrete metalla-assemblies as drug delivery vectors / Bruno Therrien<br/>Nanomaterials for management of lung disorders and drug delivery / Jyothi U. Menon, Aniket Wadajkar, Zhiwei Xie [and others]<br/>Nano-sized calcium phosphate (CaP) carriers for non-viral gene/drug delivery / Donghyun Lee, Geunseon Ahn, Prashant N. Kumta<br/>Part III: Nanotheragnostics<br/>Organics modified mesoporous silica for controlled drug delivery systems / Jingke Fu, Yang Zhao, Yingchun Zhu [and others]<br/>Responsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery / Weitai Wu, Shuiquin Zhou<br/>Core/shell nanoparticles for drug delivery and diagnosis / Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee [and others]<br/>Dendrimer nanoparticles and their applications in biomedicine / Arghya Paul, Wei Shao, Tom J. Burdon [and others]<br/>Theranostic nanoparticles for cancer imaging and therapy / Mami Murakami, Mark J. Ernsting [and others]<br/>Part IV: Nanoscaffolds technology<br/>Nanostructure polymers in function generating substitute and organ transplants / S.K. Shulka<br/>Electrospun nanofiber for three dimensional cell culture / Yashpal Sharma, Ashutosh Tiwari, Hisatoshi Kobayashi [and others]<br/>Magnetic nanoparticles in tissue regeneration / Anuj Tripathi, Jose Savio Melo, Stanislaus Francis D'Souza<br/>Core-sheath fibers for regenerative medecine / Rajesh Vasita, Fabrizio Gelain.

::Contents##<br/><br/>v. 1. Basic capabilities

::Summary## Nanotechnology is opening up new avenues in all scientific and technological fields. Among the novel applications, bioactives and nutraceuticals are fast-growing areas of nano research for better healthcare solutions. A variety of nanoformulations, such as polymeric nanoparticles, nanocapsules, nanoemulsions, transferosomes and ethosomes, liposomes, lipospheres, and lipid polymer hybrid nanoparticles have proved valuable in bioactive delivery and food materials. Further, new herbal drugs and nutraceuticals are reported to have remarkable advantages over conventional formulations of plant actives and extracts, including enhanced solubility, bioavailability, multiple drug delivery, greater stability, sustained delivery, improved tissue macrophage distribution, protection from toxicity, enhancement of pharmacological activity and protection from physical and chemical degradation. This book focuses on the advanced nanomaterials that are utilized for the encapsulation of nutrients/vitamin/phytoconstituents, as well as their other healthcare benefits.<br/>::Contents##<br/>1) Ganoderic acid for anticancer applications: Scope of nanomedicine in its effective delivery<br/>2) Vitamin E based nanomedicines for anticancer drug delivery<br/>3) Rutin based phytomedicines for cancer benefit<br/>4) Nanoformulated Drug Delivery of Potential Betulinic Acid Derivatives: A Promising Approach toward Cancer Therapy<br/>5) Quercetin Loaded Nanomedicine as Oncotherapy<br/>6) Polyunsaturated fatty acids loaded nanomedicine for solid tumor<br/>7) Rutin based phytomedicines for cancer benefit<br/>8) Quercetin Loaded Nanomedicine as Oncotherapy<br/>9) Quercetin Loaded Nanomedicine as Nutritional Applications<br/>10) Polyphenols loaded nanomedicines against skin aging<br/>11) Polyphenols loaded nanomedicines against skin aging<br/>12) LIPID NANOCARRIERS FOR DERMAL DELIVERY OF LUTEIN<br/>13) Bioactive flavonoid apigenin and its nanoformulations: a promising hope for diabetes and cancer<br/>14) Therapeutic potential of 'Aegeline an important phytochemical of Aegle marmelos: Current Health perspectives for the treatment of disease<br/>15) EPIGALOCATECHIN-3-GALLATE LOADED NANOCARRIERS FOR HEALTH BENEFITS<br/>16) Clove oil / Eugenol as the nanotechnological perspective for healthcare applications<br/>17) Clove oil / Eugenol as the nanotechnological perspective for healthcare applications.

::Contents##<br/>Nanomedicine<br/>High-technology therapy using biomolecules or synthetic compounds for hiv inhibition<br/>Emerging nanomedicine approaches for osteochondral tissue regeneration<br/>Synthesis of poly(methacrylate) encapsulated magnetite nanoparticles via phosphonic acid anchoring chemistry and its applications toward biomedicine<br/>Potentiometric PVC membrane sensors and their analytical applications in pharmaceuticals and environmental samples at micro- and nano-level<br/>Bioceramics: silica-based organic-inorganic hybrid materials for medical applications<br/>Recent advances of multifunctional nanomedicines<br/>Nanomedicinal approaches for diabetes management<br/>Polymeric nanofibers in regenerative medicine<br/>Drug delivery and therapeutics<br/>Multifunctional nano/micro polymer capsules as potential drug delivery and imaging agents<br/>Nanophosphors-nanogold immunoconjugates in isolation of biomembranes and in drug delivery<br/>Cyclodextrin-based nanoengineered drug delivery system<br/>Medicinal patches and drug nanoencapsulation: a noninvasive alternative<br/>Dendrimers: a class of polymer in the nanotechnology for drug delivery<br/>Designing nanocarriers for drug delivery<br/>Multifunctional polymeric micelles for drug delivery and therapeutics<br/>Nanoparticles-based carriers for gene therapy and drug delivery.

::Contents##<br/>Fundamentals of immunology and inflammation / Michael E. Woods<br/>Principles of nanomedicine / Wilson S. Meng and Jelena M. Janjic<br/>Nanotoxicity / Angie S. Morris and Aliasger K. Salem<br/>Translational nanomedicine / Lara Milane<br/>Inflammatory bowel disease<br/>Multiple sclerosis<br/>Asthma<br/>Neurodegenerative disease / Neha N. Parayath, Grishma Pawar, Charul Avachat, Marcel Menon Miyake, Benjamin Bleier, and Mansoor Amiji<br/>Cancer / Lara Milane<br/>Diabetes / Antonio J Ribeiro, Marlene Lopes, Raquel Monteiro, Gaia Cilloni, Francisco Veiga, Pharm.D; P. Arnaud.

::Summary## This book provides an overview of the current applications of nanomaterials in brain diseases, and introduces several novel nanomaterials that have excellent potential in this field. During the last two decades, nanotechnology had matured significantly as it has transitioned from a bench-top science to an applied technology. However, the application of nanomaterials in basic and clinical neuroscience is still at an early stage, and understanding how the intrinsic properties of nanomaterials translate to complex biological responses is an area of intensive research. Part 1 of the book focuses on the principles and strategies of nanomedicine in the brain diseases, while part 2 examines the applications of promising nanomaterials for therapy and diagnosis in the brain. Together they offer a comprehensive picture of advances in nanotechnology and their successful use in treating brain diseases in the past 20 years.<br/>::Contents##<br/>Introduction: Nanomedicine in the Brain<br/>The Strategies of Nanomaterials for Traversing Blood-Brain Barrier<br/>The Strategies of Nanomaterials for Drug Delivery and Release<br/>The Strategies of Nanomaterials for Therapy<br/>The Strategies of Nanomaterials for Diagnostic and Imaging<br/>Nanoenzyme<br/>Biomacromolecule-Based Nanomedicine<br/>Carbon-Based Nanomedicine<br/>Polymeric Nanomedicine<br/>Magnetic Nanomedicine<br/>Boron Neutron Capture Nanomedicines.

::Summary## "This book is the first in a series compiling highly cited articles in nanomedicine recently. The series is edited by Lajos P. Balogh, a prominent nanotechnology researcher and journal editor. The first book content is about nanotechnology in cancer research. It also includes a wide variety of must-know topics that will appeal to any researcher involved in nanomedicine, macromolecular science, cancer therapy, and drug delivery research. These 31 articles collected here have already acquired more than 3500 citations (i.e., over a hundred on average), highlighting the importance and recognized professional interest of the scientists working in this field. "--Provided by publisher.

::Summary## 'Nanoneuroprotection and Nanoneurotoxicology,' Volume 245 of the Progress in Brain Research series, deals with recent developments in the field of neurotoxicity and neuroprotection using nanobiotechnology for the first time. Chapters in this updated release include Sleep deprivation induced brain pathology and concussive head trauma-Neuroprotective effects of nanowired delivery of drugs and hormones, Nanomedicine in Alzheimer’s Disease: amyloid beta targeting strategy, How traumatic brain injury alters amino acids balance in the central nervous system-Neuroprotection by TiO2 nanowired delivery of drugs and antibodies, Nanowired delivery of DL-3-n-butylphthalide and neuroprotection in concussive head injury, Nanodelivery of drugs and antibodies for superior neuroprotection in Alzheimer’s disease, and more. Key Features: Highlights recent development in nanopharmacetical research with reference to brain disease; Provides new insights on the possible role of nanomaterials and their pronounced effects on CNS injury or repair. Readership: Researchers and students of neuroscience, psychology, and the biological sciences interested in nanoneuroprotection and nanoneurotoxicology. -- Provided by publisher.

::Summary## Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage.<br/>::Contents##<br/>How innate and adaptive immunity work<br/>Nanoparticles and innate immunity<br/>Nanoparticles and adaptive immunity<br/>Nanoparticles and allergy<br/>Nanoparticles and immunological frailty<br/>Nanoparticles in medicine: nanoparticle engineering for macrophage targeting and nanoparticles that avoid macrophage recognition<br/>Summary and outlook.

::Summary## Nanotechnology is expected to bring revolutionary changes in a variety of fields. This volume describes nanoparticles and their biomedical applications, and covers metal nanoparticles, metal oxide nanoparticles, rare earth based nanoparticles and graphene oxide nanoparticles. It elaborates on a number of biomedical applications, including therapeutic applications. It addresses the topic of green synthesis, in view of increasing health and environmental concerns.<br/>::Contents##<br/>Chapter 1. Rare Earth Based Nanoparticles: Biomedical Applications, Pharmacological and Toxicological Significance<br/>Chapter 2. Nanomedicine for Hepatic Fibrosis<br/>Chapter 3. Biomedical Applications of Zinc oxide nanoparticles synthesized using Eco-friendly method<br/>Chapter 4. Potential Applications of Greener synthesized Silver and Gold Nanoparticles in Medicine<br/>Chapter 5. Nanofinished Medical Textiles and Their Potential Impact to Health and Environment<br/>Chapter 6. Therapeutic Applications of Graphene Oxides in Angiogenesis and Cancers<br/>Chapter 7. Use of nanoparticles to manage Candida biofilms<br/>Chapter 8. Biomedical applications of lignin-based nanoparticles<br/>Chapter 9. Green nanoparticles for biomedical and bioengineering applications<br/>Chapter 10. Nanoparticles: A boon to target mitochondrial diseases.

::Summary## "This book introduces nanoparticles as a powerful platform for vaccine design. Current challenges in vaccine development are discussed and the unique advantages nanoparticles provide in overcoming these challenges are explored. The authors offer fascinating insights into the immunological assets of using nanoparticles as delivery vehicles or adjuvants and present different materials that are being used in nanoparticle-based vaccine development, covering peptides, proteins, polymers, virus-like particles, and liposomes. Its contemporary research insights and practical examples for applications make this volume an inspiring read for researchers and clinicians in vaccinology and immunology. Chapter "Liposome Formulations as Adjuvants for Vaccines" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com."--Publisher's description.<br/>::Contents##<br/>Liposome formulations as adjuvants for vaccines / Mangala Rao, Kristina K. Peachman, and Carl R. Alving<br/>Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles / Elizabeth A. Grego, Alaric C. Siddoway, Metin Uz, Luman Liu, John C. Christiansen, Kathleen A. Ross, Sean M. Kelly, Surya K. Mallapragada, Michael J. Wannemuehler, and Balaji Narasimhan<br/>Virus-like particle vaccines against respiratory viruses and protozoan parasites / Ki-Back Chu and Fu-Shi Quan<br/>Protein and peptide nanocluster vaccines / Timothy Z. Chang and Julie A. Champion.

::Summary## This book describes the medical applications of inorganic nanoparticles. Nanomedicine is a relatively advanced field, which enhances the treatment of various diseases, offering new options for overcoming the problems associated with the use of conventional medicines. Discussing the toxicological and safety aspects associated with medical applications of nanoparticles, the book presents the latest research on topics such as emerging nanomaterials for cancer therapy, applications of nanoparticles in dentistry, and fluoride nanoparticles for biomedical applications, and also includes chapters on the use of nanoparticles such as silver and gold. .<br/>::Contents##<br/>Biomedical applications of characterized zinc oxide nanoparticles synthesized using eco-friendly methods<br/>Semiconductor and metal oxide nanoparticles for nanomedical applications<br/>Fungal mediated nanoparticles: Characterization and biomedical advances<br/>Applications of green synthesized silver and gold nanoparticles in medicine<br/>Nanoparticle applications in dentistry: Current trends<br/>Nanoparticles in dentistry: Current trends<br/>Nanoparticle applications in dermatology: Current trends<br/>Nanoparticles in medicine: Therapeutic toxicity issues.

::Summary## This book summarizes the latest advances in nanophotonics for biomedical applications, including biomolecular sensing and imaging, additive fabrications, and biophotonics. The engineering of nanophotonics will have significant impacts on the life sciences and medicine alike. Given its scope, the book offers a valuable asset for researchers, scientists, engineers, and graduate students in the fields of biomedical engineering, electrical engineering, materials sciences, optics, biology, and medicine.<br/>::Contents##<br/>Photonic crystals for biomolecule sensing applications<br/>Recent advances in Surface Plasmon Resonance for biosensing applications and future prospects<br/>Surface-enhanced Raman Scattering for biology and medicine<br/>Nanophotonic techniques for single cell analysis<br/>Biointerface Characterization by Nonlinear Optical Spectroscopy<br/>Chemiluminescence and its biomedical applications<br/>Luminescent Conjugated Polymer Dots for Biomedical Applications<br/>Dark-Field Hyperspectral Imaging (DF-HSI) Modalities for Characterization of Single Molecule and Cellular Processes<br/>Additive Manufacturing Technologies based on Photopolymerization.

::Summary## Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized.<br/>::Contents##<br/>1. Fabrication of polymeric core-shell nanostructures<br/>2. Emulsification-diffusion method to obtain polymeric nanoparticles: two decades of research<br/>3. Tools and Techniques for the optimized synthesis, reproducibility and scale up of desired nanostructures from plant derived material and their role in pharmaceutical properties<br/>4. Scale up of biopharmaceuticals production<br/>5. Physicochemical and morphological characterization of pharmaceutical nanocarriers and mathematical modelling of drug encapsulation/release mass transfer processes<br/>6. Biopharmaceutics and pharmacokinetics of multifunctional nanoparticles<br/>7. Technological delivery systems to improve biopharmaceutical properties<br/>8. From physicochemically stable nanocarriers to targeted drug delivery: in-vivo pharmacokinetic, pharmacodynamic and biodistribution studies<br/>9. Sterile dosage forms loaded nanosystems for parenteral, nasal, pulmonary and ocular administration<br/>10. Quantitative Characterization of Targeted Nanoparticulate Formulations for Prediction of Clinical Efficacy<br/>11. Analytical tools for reliable in vitro and in vivo performance testing of drug nanocrystals<br/>12. Application of one-step affinity purification of drug-binding proteins with practical magnetic nanoparticles to drug discovery<br/>13. Molecularly Imprinted Polymers as Separation Tools<br/>14. Detection of DNA damage induced by nanomaterials<br/>15. Pharmacological usage of an enzyme inhibitor - a selective inhibitor of 3-mercaptopyruvate sulfurtransferase reaction intermediate to control generation of polysulfide<br/>16. Regulatory Consideration in Nanotechnology Based Drug Products.

::Summary## This book presents a blueprint for researchers in the area of nanotechnology for chemical defense, especially with regard to future research on detection and protection. It addresses the synthesis of complex nanomaterials with potential applications in a broad range of sensing systems. Above all, it discusses novel experimental and theoretical tools for characterizing and modeling nanostructures and their integration in complex systems. The book also includes electronic structure calculations exploring the atomic and quantum mechanical mechanisms behind molecular binding and identification, so as to provide readers with an in-depth understanding of the capabilities and limitations of various nanomaterial approaches. Gathering contributions by scientists with diverse backgrounds, the book offers a wealth of insightful information for all scientists whose work involves material science and its applications in sensing.<br/>::Contents##<br/>The feasibility of graphene-based defense applications: an industry perspective<br/>Carbon nanomaterials integrated in rugged and inexpensive sensing platforms for the in-field detection of chemical warfare agents;<br/>Sensing volatile organic compounds by phthalocyanines with metal centers: exploring the mechanism with measurements and modelling<br/>Chemical sensors for VOC detection in indoor air: focus on formaldehyde<br/>Gas sensing using monolayer MoS2; R. Canton-Vitoria et al<br/>Progress of Sensors based on hollow metal sulfides nanoparticles<br/>Synthesis of 3D-ensembles of carbon nanotubes<br/>Challenges on the production and characterization of B-doped single-walled carbon nanotubes<br/>Graphene-based metal-free catalysis: a spectroscopic point-of-view<br/>Graphene for Photodynamic Therapy.

::Summary## Unique in combining the expertise of practitioners from university hospitals and that of academic researchers, this timely monograph presents selected topics catering specifically to the needs and interests of natural scientists and engineers as well as physicians who are concerned with developing nanotechnology-based treatments to improve human health. To this end, the book cover the materials aspects of nanomedicine, such as the hierarchical structure of biological materials, the imaging of hard and soft tissues and, in particular, concrete examples of nanotechnology-based approaches in modern medical treatments. The whole is rounded off by a discussion of the opportunities and risks of using nanotechnology and nanomaterials in medicine, backed by case studies taken from real life.<br/>::Contents##<br/>Part I. Introduction to nanoscience in medicine of the twenty-first century<br/>Chapter 1. Challenges and opportunities of nanotechnology for human health<br/>Chapter 2. Nanoscience and nanotechnology and the armory for the twenty-first centrury health care<br/>Chapter 3. Nanomedicine activities in the United States and worldwide<br/> Part II. Leading cause of death: cardiovascular diseases<br/>Chapter 4. Challenges in cardiovascular treatments using nanotechnology-based approaches<br/>Chapter 5. Smart container for targeting drug delivery<br/>Chapter 6. Human nano-vesicles in physiology and pathology<br/>Chapter 7. Challenges and risks of nanotechnology in medicine: an immunologist's point of view<br/>Part III. Second most common cause of death: cancer<br/>Chapter 8.Challenges of applying targeted nanostructures with multifunctional properties in cancer treatments<br/>Chapter 9. Highly conformal radiotherapy using protons<br/>Chapter 10. Self-organization on a chip: from nanoscale actin assemblies to tumor spheroids<br/>Chapter 11. The nanomechnaical signature of tissues in health and disease<br/>Part IV. Most common diseases: caries, musculoskeletal diseases, incontinence, allergies<br/>Chapter 12. Revealing the nano-architecture of human hard and soft tissues by spatially resolved hard X-Ray scattering<br/>Chapter 13. Regenerative dentistry using stem cells and nanotechnology<br/>Chapter 14. Nanostructured polymers for medical applications<br/>Chapter 15. Nanotechnology in the treatment of incontinence<br/>Chapter 16. Nanomedicine in dermatiology: nanotechnology in prevention, diagnosis, and therapy<br/>Part V. Benefiting patients<br/>Chapter 17. Therapeutic development and the evolution of precision medicine<br/>Chapter 18. Benefit from nanoscience and nanotechnology: benefitting patients<br/>Index.

::Summary## This book discusses the ability of nanomaterials to protect crop-plant and animal health, increase production, and enhance the quality of food and other agricultural products. It explores the use of targeted delivery and slow- release agrochemicals to reduce the damage to non-target organisms and the quantity released into the soil and water, as well as nanotechnology-derived tools in the field of plant and animal genetic improvement. It also addresses future applications of nanotechnology in sustainable agriculture and the legislative regulation and safety evaluation of nanomaterials. The book highlights the recent advances made in nanotechnology and its contribution towards an eco-friendly approach in agriculture.<br/>::Contents##<br/>Intro; Preface; Contents; Contributors; Nanomaterials in Crop Science; 1 Application of Nanotechnology in Genetic Improvement in Crops; Abstract; 1.1 Introduction; 1.2 Conventional Plant Biotransformation Techniques; 1.3 Why Nanotechnology?; 1.4 Nanocarriers for Plant Biotransformation; 1.4.1 Silica Nanoparticles; 1.4.2 Calcium-Based Nanoparticles; 1.4.3 Magnetic Nanoparticles; 1.4.4 Dendrimers; 1.4.5 Liposomes; 1.4.6 Gold Nanoparticles; 1.4.7 Carbon Nanotubes; 1.4.8 Other Nanoparticles; 1.5 Patented Technologies; 1.6 Concluding Remarks and Future Perspectives; References 2 Engineered Nanoparticles for Increasing Micronutrient Use EfficiencyAbstract; 2.1 Introduction; 2.2 Nanoparticles as Micronutrients; 2.2.1 Iron (Fe) NPs; 2.2.2 Manganese (Mn) NPs; 2.2.3 Zinc (Zn) NPs; 2.2.4 Copper (Cu) NPs; 2.2.5 Molybdenum (Mo) NPs; 2.3 Uptake of Nanomaterials in Plants; 2.4 Toxicity Aspects of Nanoparticles; 2.5 Conclusion and Future Aspects; References; 3 Nano-biofertilizers: Harnessing Dual Benefits of Nano-nutrient and Bio-fertilizers for Enhanced Nutrient Use Efficiency and Sustainable Productivity; Abstract; 3.1 Introduction 3.1.1 Fertilizers and Their Role for Crop Productivity3.1.1.1 Fertilizer Application Techniques; 3.1.1.2 Tackling the 'Over-Fertilization' Peril; 3.1.2 Organic Fertilization: Aiming for Eco-Friendly Green Revolution; 3.2 Bio-fertilizers: Pursuit for Sustainable Agricultural Productivity; 3.3 Nano-fertilizers; 3.3.1 Conventional Fertilizers Versus Nano-fertilizers; 3.3.2 What Are Nano-fertilizers?; 3.3.3 Nano-fertilizers in Precision Agriculture; 3.3.3.1 Nano-'smart'-fertilizers for Slow/Controlled Release of Nutrients 3.4 Nano-biofertilizers: Augmenting the Benefits of Nano- and Bio-fertilizers3.4.1 Contributions of the Nano- and Bio-components of the Nano-biofertilizer; 3.4.2 Why Will It Impart Added Benefits?; 3.4.3 Studies Involving Combinatorial Use of Nano- and Bio-fertilizers; 3.4.3.1 Cereal Crops; 3.4.3.2 Legume Crops; 3.4.3.3 Horticultural Crops; 3.4.3.4 Forage Crops; 3.5 Environmental Safety Issues; 3.6 Future Prospects; Acknowledgements; References; 4 Role of Metal-Organic Framework (MOF) for Pesticide Sensing; Abstract; 4.1 Introduction; 4.2 Synthesis of MOF; 4.2.1 Traditional Synthesis Methods 4.2.2 Microwave Synthesis4.2.3 Electrochemical Synthesis; 4.2.4 Mechanochemical Synthesis; 4.2.5 Sonochemical Synthesis; 4.3 Applications of MOF for Pesticide Sensing; 4.3.1 Magnetic Solid-Phase Extraction (MSPE) Extracted Magnetic MOF Composites for Pesticide Detection; 4.3.2 Gas Chromatography Coupled with MOF for Pesticide Detection; 4.3.3 MOF Coupled Adsorption for Pesticide Detection; 4.3.4 Detection of Pesticide by Optical Method; 4.3.5 Electrochemical Method of Pesticide Detection; 4.3.6 SERS Active Metal-Organic Framework with Embedded Gold Nanoparticles

::Summary## In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications. The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner. The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit a target of dreadful healthcare conditions such as cancer , immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties. Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.<br/>::Contents##<br/>Intro<br/>Preface<br/>Contents<br/>Contributors<br/>About the Editors<br/>Chapter 1: Nanomaterials: Therapeutic Agent for Antimicrobial Therapy<br/>1.1 Introduction<br/>1.1.1 Basic Discussion About Bacterial Cells<br/>1.1.2 How Nanomaterials or Antibacterial Agent Interact with Bacteria: Probable Mechanism<br/>1.1.2.1 Interaction of Nanomaterials with Bacterial Cell Membrane<br/>1.1.2.2 Release of Compounds/Metal Toxic to the Bacterial Cell<br/>1.1.2.3 Role of Reactive Oxygen Species (ROS) in Cell Damage<br/>1.1.2.4 Obstacle in Electron Transport and Protein Oxidation 1.2 Essay for Measuring the Antimicrobial Activity of Nanomaterials<br/>1.2.1 Susceptibility of Nanomaterials Toward Microorganisms<br/>1.2.1.1 Dilution Method<br/>1.2.1.2 Disc-Diffusion Method<br/>1.2.2 Methods for Quantification of Antibacterial Activity<br/>1.2.2.1 Optical Density (OD) Measurement<br/>1.2.2.2 Cell Counting Method<br/>1.2.2.3 Spread-Plate Colony Counts<br/>1.2.2.4 Crystal Violet Staining<br/>1.2.2.5 Live/Dead Cell Staining and Imaging<br/>1.2.2.6 Tetrazolium Salt Reduction<br/>1.3 Role of Nanomaterials as Antimicrobial Agent<br/>1.3.1 The Ancient Era 1.3.2 Why Nanomaterials Have Replaced the Ancient Antimicrobial Agents?<br/>1.4 Different Class of Nanomaterials Used as an Antimicrobial Agent<br/>1.4.1 Antimicrobial Properties of Silver-Based Nanomaterials<br/>1.4.2 Antimicrobial Activity of Zinc Oxide Nanomaterials (ZnO)<br/>1.4.3 Antimicrobial Activity of Titanium Oxide (TiO2) Nanomaterials<br/>1.4.4 Copper Nanomaterials as an Antimicrobial Agent<br/>1.4.5 Carbon-Based Nanomaterials as an Antimicrobial Agent<br/>1.4.5.1 Fullerene<br/>1.4.5.2 Carbon Nanotubes (CNTs)<br/>1.4.5.3 Graphene Oxide (GO) 1.4.5.4 Activated Carbon-Based Nanomaterials (ACNMs)<br/>1.5 Challenges of Nanomaterials in Antibacterial Treatments<br/>References<br/>Chapter 2: A Review on Next-Generation Nano-Antimicrobials in Orthopedics: Prospects and Concerns<br/>2.1 Introduction<br/>2.2 Orthopedic Implants and Infections<br/>2.2.1 Planktonic<br/>2.2.2 Biofilm<br/>2.2.3 Invasive and Intracellular<br/>2.3 Bacterial Growth and Related Clinical Complications<br/>2.3.1 Cell Adhesion<br/>2.3.2 Cellular Aggregation<br/>2.3.3 Biofilm Maturation<br/>2.3.4 Cellular Detachment<br/>2.4 Conventional Techniques for Treating Infections 2.5 Nanomaterials in Eradicating Infections<br/>2.6 Mechanism of Action for Nanobiotics<br/>2.7 Future Perspectives and Concerns<br/>References<br/>Chapter 3: Antibacterial Activity by Functionalized Carbon Nanotubes<br/>3.1 Introduction<br/>3.2 Synthesis of Functionalized Carbon Nanotubes<br/>3.3 Characterization of Functionalized Carbon Nanotubes<br/>3.4 Antimicrobial Activity of Functionalized Carbon Nanotubes<br/>3.4.1 Single-Walled Carbon Nanotubes<br/>3.4.2 Multiwalled Carbon Nanotubes<br/>3.5 Mechanisms of Action by Functionalized Carbon Nanotubes<br/>3.6 Conclusion<br/>References

::Contents##<br/>1. Cell and organ drug targeting: types of drug delivery systems and advanced targeting strategies<br/>2. Cell-penetrating peptides in nanodelivery of nucleic acids and drugs<br/>3. The current perspectives of nanoparticles in clellular and organ-specific drug targeting in biological system<br/>4. Precision medicine and drug targeting: the promise versus reality of target-specific drug delivery<br/>5. Brain targeting of payload using mild magnetic field: site specific delivery<br/>6. Nanoparticles influence in skin penetration of drugs: in vitro and in vivo characterization<br/>7. DNA aptamer-based molecular nanoconstructions and nanodevices for diagnostics and therapy<br/>8. Nanobiodevices for electrochemical biosensing of pharmaceuticals<br/>9. Imprinted polymeric nanoparticles as nanodevices, biosnesors and biolabels<br/>10. Poly(lactic-co-glycolic acid) (PLGA) matrix implants<br/>11. Hydrogels for biomedical applications<br/>12. Silk-based matrices for bone tissue engineering applications<br/>13. Implantable drug delivery systems: an overview<br/>14. Nanobionics and nanoengineered prosthetics<br/>Index.

::Summary## Uses of nanotechnology in various fields, and cautions or safety measures regarding some of those applications.<br/>::Contents##<br/>Nanotechnology Overview: Opportunities and Challenges / Cheng, H. N., USDA Agricultural Research Service, Southern Regional Research Center, 1100 Robert E. Lee Boulevard, New Orleans, Louisiana 70124, United States; Doemeny, Laurence J., 4922 Armin Way, San Diego, California 92115, United States; Geraci, Charles L., National Institute for Occupational Safety and Health (NIOSH), 1090 Tusculum Avenue, C-14, Cincinnati, Ohio 45226, United States; Grob Schmidt, Diane, Department of Chemistry, University of Cincinnati, 301 Clifton Court, Cincinnati, Ohio 45221, United States / http://dx.doi.org/10.1021/bk-2016-1220.ch001<br/>Nanotechnology at Northwestern University: Delivering on the Promise / Mirkin, Chad A. / http://dx.doi.org/10.1021/bk-2016-1220.ch002<br/>The Role of Chemical Sciences in the National Nanotechnology Initiative: Accomplishments and Future Direction / Fadel, Tarek R., The International Technology Research Institute, 518 S. Camp Meade Road, Suite 6, Linthicum, Maryland 21090, United States; Meador, Michael A., The National Nanotechnology Coordination Office, 4201 Wilson Boulevard, Suite 405, Arlington, Virginia 22230, United States / http://dx.doi.org/10.1021/bk-2016-1220.ch003<br/>Building Foundational Knowledge and Infrastructure for Nanotechnology: 2000-2030 / Roco, Mihail C. / http://dx.doi.org/10.1021/bk-2016-1220.ch004<br/>Nanomaterials and Nanomanufacturing with an Emphasis on National Security / Sloter, Lewis E. / http://dx.doi.org/10.1021/bk-2016-1220.ch005<br/>National Institutes of Health: An Introduction to Nanotechnology Funded Research in Biology and Medicine / Henderson, Lori A. / http://dx.doi.org/10.1021/bk-2016-1220.ch006<br/>University Roles in Economic Development / Liehr, Michael / http://dx.doi.org/10.1021/bk-2016-1220.ch007<br/>Regulations: Facilitating Advancement or Serving as a Barrier<br/>A Shared Responsibility / Medley, Terry L. / http://dx.doi.org/10.1021/bk-2016-1220.ch008<br/>Sustainability and Life-Cycle Issues / Morris, Jeffrey / http://dx.doi.org/10.1021/bk-2016-1220.ch009<br/>Nanomaterials: Promise in Balance with Safety / Philbert, Martin A. / http://dx.doi.org/10.1021/bk-2016-1220.ch010<br/>Opportunities and Challenges for Health, Safety, and the Environment: The Regulatory Void? / Bergeson, Lynn L. / http://dx.doi.org/10.1021/bk-2016-1220.ch011<br/>Adaptive Governance for the Nanotechnology Workplace / Murashov, Vladimir; Howard, John / http://dx.doi.org/10.1021/bk-2016-1220.ch012<br/>What Is Responsible Development of Nanotechnology? / Lin, Albert / http://dx.doi.org/10.1021/bk-2016-1220.ch013<br/>Editorsʼ Biographies / http://dx.doi.org/10.1021/bk-2016-1220.ot001

::Contents##<br/>Nanoflares as Probes for Cancer Diagnostics<br/>Therapeutic Applications of Spherical Nucleic Acids<br/>Theranostic Magnetic Nanostructures (MNS) for Cancer<br/>Nanodiamond-Based Chemotherapy and Imaging<br/>Theranostic Lipid Nanoparticles for Cancer Medicine<br/>Synthetic High-Density Lipoprotein-Like Nanoparticles as Cancer Therapy<br/>Radiosensitization and Nanoparticles<br/>Hybrid Nanoparticles for Cancer Imaging and Therapy<br/>Exploring Tumor Microenvironment with Nanoparticles<br/>How nanoparticles interact with cancer cells<br/>Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics<br/>Calibration-Quality Cancer Nano-Therapeutics<br/>Cancer Nano-Therapeutics in Clinical Trials.

::Summary## Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies.<br/>::Contents##<br/>1. Tumors of the central nervous system: anatomy and interventional considerations<br/>2. Angiogenesis in brain tumors<br/>3. Physiology of the blood-brain barrier and mechanisms of transport across the BBB<br/>4. Active trageted nanoscale delivery systems for brain tumor therapeutics<br/>5. Nanotechnology in brain tumor targeting: efficacy and safety of nanoenabled carriers undergoing clinical testing<br/>6. Targeting of lipid/polymeric (hybrid) nanoparticles to the brain for the treatment of degernative diseases<br/>7. Biopolymeric nanoparticles for targeted drug delivery to brain tumors<br/>8. Solid lipid nanoparticles for targeted drug delivery<br/>9. Liposome-based drug delivery for brain tumor theranostics<br/>10. Dendrimers as effective carriers for the treatment of brain tumor - 11. Micelle-based drug delivery for brain tumors<br/>12. Nanemulsions-based drug delivery for brain tumors<br/>13. Immune infiltration in malignant gliomas<br/>14. Carbon nanotubes (CNTs): a novel drug delivery tool in brain tumor treatment<br/>15. Beyond the blood-brain barrier: facing new challenges and prospects of nanotechnology-mediated targeted delivery to the brain<br/>Index.

::Summary## The emergence of nanotechnology and the development of new nano-devices and nanomaterials open up opportunities for novel applications in agriculture and biotechnology. Nanotechnology has the potential to modernize the agricultural research and practice. Nanotechnology has gained momentum in agriculture sector during last decade, but still there are knowledge gap between scientific communities. This book comprise of holistic coverage about current developments in nanotechnology based sustainable agriculture. It contains sections focusing on each aspect of the implications of nanotechnology in different sectors of agriculture from crop production, soil fertility management, crop improvement etc. It also provides insight into the current trends and future prospects of nanotechnology along with the benefits and risks and their impact on agricultural ecosystems. This book emphasize on use of nanotechnology to reduce agrochemical usage via smart delivery system, increase nutrient use efficiency, improved water and nutrient management, nano-biosensors for management of plant diseases etc. The book provides thorough knowledge for dealing with current challenges of agricultural sector using nanotechnology based agricultural interventions. It will serve as reference literature for scientists, policymakers, students and researchers who are engaged in development of strategies to cope up with challenges of current agricultural systems and society.<br/>::Contents##<br/>1) Nanotechnology in agriculture<br/>2) Bio production of silver nanoparticles and its potential applications in Agriculture<br/>3) Biological Synthesis of Nanoparticles using bacteria<br/>4) Biofabrication of Nanoparticles using fungi<br/>5) Nanoformulations Based on Bacillus subtilis Lipopeptides: The Future of Agriculture: Fruits<br/>6)Use of bio-based nanoparticles in Agriculture<br/>7) Uptake, Accumulation and toxicity of metal nanoparticles in autotroph<br/>8) Carbon Nanotubes in Agriculture: Production, Potential and Prospects<br/>9) Impact and current perspectives of zinc oxide nanoparticles on soil<br/>10) Soil ecological pros and cons of nanomaterials: Impact on micro-organisms and soil health<br/>11) Beneficial effects of metal- and metalloid-based nanoparticles on crop production<br/>12) Environmental impact and Eco-toxicological influence of biofrabricated nanoparticle on soil activity<br/>13) Nanobiosensors: A novel approach in precision agriculture<br/>14) Nanoparticle mediated plant gene transfer for precision farming and sustainable agriculture<br/>15) Nanotechnology for polluted soil remediation.

::Summary## The emergence of nanotechnology and the development of new nanodevices and nanomaterials have opened up exciting opportunities for novel applications in agriculture and biotechnology. Nanotechnology has the potential to modernize agricultural research and practice, but although it has gained momentum in the agriculture sector over last decade, there are still knowledge gaps between scientific communities. This book presents a comprehensive overview of current developments in nanotechnology-based sustainable agriculture. Focusing on various aspects of nanotechnology in different sectors of agriculture, such as crop production, soil fertility management and crop improvement, it offers insights into the current trends and future prospects of nanotechnology, along with the benefits and risks and their impact on agricultural ecosystems. It also highlights the use of nanotechnology to reduce agrochemical usage, to increase nutrient uptake efficiency and to improve water and nutrient management, and the use of nano-biosensors to manage plant diseases. The book is a valuable reference resource for scientists, policymakers, students and researchers who are engaged in developing strategies to cope with current agricultural challenges.<br/>::Contents##<br/>Intro; Preface; Contents; About the Editors;<br/> 1: Nanobiotechnology for Agricultural Productivity, Food Security and Environmental Sustainability; 1.1 Introduction; 1.2 Nanotechnology for Agricultural Productivity; 1.2.1 Nanofertilizers; 1.2.2 Nanopesticides; 1.2.3 Nanoparticle-Based Plant Gene Transfer; 1.3 Nanotechnology for Food Security; 1.3.1 Nutrients and Dietary Supplements; 1.3.2 Nanoparticles in Food Processing; 1.3.3 Nanotechnology in Food Packaging and Storage; 1.4 Nanotechnology for Environmental Sustainability; 1.5 Ecological and Health Risks of Nanoparticles 1.6 Conclusion and Future PerspectivesReferences;<br/> 2: Nanofertilizers: A Recent Approach in Crop Production; 2.1 Introduction; 2.2 Challenges of Existing Agricultural Practices; 2.3 Nanofertilizer and Its Role in Agriculture; 2.4 Properties of Nanofertilizer; 2.5 Nanofertilizer a Better Option than Conventional Fertilizers; 2.6 Synthesis of Nanofertilizers; 2.7 Types of Nanofertilizers; 2.7.1 Nitrogen-Based Nanofertilizers; 2.7.2 Phosphate-Based Nanofertilizers; 2.7.3 Iron-Based Nanofertilizers; 2.7.4 Zinc-Based Nanoparticles as Fertilizers; 2.7.5 Titanium-Based Nanofertilizers 2.14 Biosafety Issues Related to the Use of Nanofertilizers2.15 Future Prospects; 2.16 Conclusion; References;<br/> 3: Nanofertilizers: Smart Delivery of Plant Nutrients; 3.1 Introduction; 3.2 Nanotechnology in Agriculture; 3.2.1 Plant Nutrients; 3.2.2 Fertilizers for Nutrients; 3.2.3 Nanomaterials for Slow and Controlled Release of Nutrients; 3.2.4 Smart Delivery of Nutrients; 3.2.5 Nanoformulations for Smart Delivery of Nutrients; 3.2.5.1 Nanoformulations of Macronutrients; 3.2.5.2 Nanoformulations of Micronutrients; 3.2.5.3 Nanoformulations of Biofertilizers; 3.3 Future Prospects 2.7.6 Aluminum-Based Nanoparticles as Fertilizers2.7.7 Copper-Based Nanofertilizers; 2.7.8 Silver-Based Nanofertilizers; 2.8 Nanofertilizer Formulation and Their Delivery System; 2.9 Uptake, Translocation, and Fate of Nanofertilizers in Plants; 2.9.1 Movement of Nanoparticles Inside Plants; 2.10 Fate of Nanofertilizers in Ecosystems; 2.10.1 Different Effects of Nanofertilizers; 2.10.1.1 Plant Toxicity; 2.10.1.2 Effects on Biodiversity and Abundance; 2.11 Nanofertilizers Products; 2.12 Economic Analysis of Nanofertilizers; 2.13 Applications of Nanofertilizers 3.4 Safety and Ethical Issues3.5 Conclusions; References;<br/> 4: Nanoelements: An Agricultural Paradigm for Targeted Plant Nutrition Therapeutic Approach; 4.1 Introduction; 4.2 Nano-fertilizers; 4.2.1 Types of Plant Nutrients; 4.2.2 Micronutrient Fertilizer; 4.3 Why Are Nano-nutrients Required?; 4.4 Need of Nanoagri-nutrient Technology; 4.5 Application of Nanotechnology in Agriculture; 4.6 Nanoparticles as Target Delivery Vehicles; 4.7 Conclusions; References;<br/> 5: Nanoparticles for the Improved Crop Production; 5.1 Introduction

::Summary## This book documents the tremendous progress in the use of nanotechnology for a range of bioapplications with the aim of providing students, researchers, technicians, and other professionals with an up-to-date overview of the field. After a general introduction to the surface modifications of nanoparticles required for different biological applications, and to the properties of the modified nanoparticles, a series of chapters describe the state of the art in respect of different types of nanoparticle, including silica nanoparticles, fluorescent nanomaterials, metal nanoparticles, magnetic nanoparticles, carbon-based nanostructures, and other novel nanomaterials. Detailed information is supplied on methods of preparation, chemical and physical properties, and current and potential applications. The closing chapters discuss lithography methods for the top-down approach to nanoparticle synthesis and the use of spectroscopic studies as a tool for the characterization of each nanoparticle. Future prospects and challenges for the development of further nanomaterials with bioapplications are also covered.

::Summary## In three handy volumes, this ready reference provides a detailed overview of nanotechnology as it is applied to energy sustainability. Clearly structured, following an introduction, the first part of the book is dedicated to energy production, renewable energy, energy storage, energy distribution, and energy conversion and harvesting. The second part then goes on to discuss nano-enabled materials, energy conservation and management, technological and intellectual property-related issues and markets and environmental remediation. The text concludes with a look at and recommendations for future technology advances. An essential handbook for all experts in the field - from academic researchers and engineers to developers in industry.<br/>::Contents##<br/>Energy Production. Fossil Fuels: The Effect of Zeolite Catalyst Particle Morphology on Catalyst Performance in the Conversion of Methanol to Hydrocarbons / Katarzyna Anna Łukaszuk, Pablo del Campo Huertas, Andrea Molino, Malte Nielsen, Daniel Rojo-Gama, Juan Salvador Martinez-Espin, Karl Petter Lillerud, Unni Olsbye, Silvia Bordiga, Pablo Beato, Stian Svelle<br/>Fossil Fuels: Nanotechnologies for Petroleum Reservoir Engineering / Igor N Evdokimov<br/>Fossil Fuels: Coke-Resistant Nanomaterials for Gas-to-Liquid (GTL) Fuels / Brian A Rosen, Sarika Singh<br/>Photovoltaics: Light Energy Harvesting with Plasmonic Nanoparticle Networks / Jean-Paul Hugonin, Mondher Besbes, Philippe Ben-Abdallah<br/>Photovoltaics: Role of Nanotechnology in Dye-Sensitized Solar Cells / Murugesan Janani, Shantikumar V Nair, A Sreekumaran Nair<br/>Photovoltaics: Nanomaterials for Photovoltaic Conversion / Abdelilah Slaoui, Daniel Lincot, Jean François Guillemoles, Ludovic Escoubas<br/>Photovoltaics: Light-Trapping in Crystalline Silicon and Thin-Film Solar Cells by Nanostructured Optical Coatings / Pierpaolo Spinelli, Bonna K Newman, Albert Polman<br/>Photovoltaics: Nanoengineered Materials and Their Functionality in Solar Cells / Kaining Ding, Thomas Kirchartz, Karsten Bittkau, Andreas Lambertz, Vladimir Smirnov, Jürgen Hüpkes, Uwe Rau<br/>Nonselective Coatings for Solar Thermal Applications in CSP / Raj Kumar Bera, Daniel Mandler, Shlomo Magdassi<br/>Selective Surfaces for Solar Thermal Energy Conversion in CSP: From Multilayers to Nanocomposites / Audrey Soum-Glaude, Laurie Di Giacomo, Sébastien Quoizola, Thomas Laurent, Gilles Flamant<br/>Nanobiotechnology Augmenting Biological Gaseous Energy Recovery / Shantonu Roy, Debabrata Das<br/>Nanotechnologies in Sodium-Cooled Fast Spectrum Reactor and Closed Fuel Cycle Sustainable Nuclear Energy System / Baldev Raj, U Kamachi Mudali<br/>Nanotechnology and Applications for Electric Power: The Perspective of a Major Player in Electricity / Didier Noël<br/>Lightweight Nanostructured Materials and Their Certification for Wind Energy Applications / Bikramjit Basu, Sherine Alex, N Eswara Prasad<br/>Energy Storage and Distribution. Nanostructured Materials for Next-Generation Lithium-Ion Batteries / T Sri Devi Kumari, T Prem Kumar, AK Shukla<br/>Carbon Nanotube Materials to Realize High-Performance Supercapacitors / Anthony Childress, Jingyi Zhu, Mehmet Karakaya, Deepika Saini, Ramakrishna Podila, Apparao Rao<br/>Recent Developments and Prospects of Nanostructured Supercapacitors / Katherine L Van Aken, Yury Gogotsi<br/>Nanostructured and Complex Hydrides for Hydrogen Storage / Lars H Jepsen, Mark Paskevicius, Torben R Jensen<br/>Nanotechnology for the Storage of Hydrogen / Marek Nowak, Mieczyslaw Jurczyk<br/>Phase Change Nanomaterials for Thermal Energy Storage / Kinga Pielichowska, Krzysztof Pielichowski<br/>Carbon Nanotube Wires and Cables: Near-Term Applications and Future Perspectives / Jeremy Lee, Seeram Ramakrishna<br/>Energy Conversion and Harvesting. Nanostructured Thermoelectric Materials: Current Research and Future Challenges / Hilaal Alam, Seeram Ramakrishna<br/>Nanostructured Cost-Effective and Energy-Efficient Thermoelectric Materials / Zhi-Gang Chen, Jin Zou<br/>Nanomaterials for Fuel Cell Technology / KS Dhathathreyan, N Rajalakshmi, R Balaji<br/>Contributions of Nanotechnology to Hydrogen Production / Sambandam Anandan, Femi Thomas Cheruvathoor, Muthupandian Ashokkumar<br/>Nanoenhanced Materials for Photolytic Hydrogen Production / Xiuquan Gu, Shuai Yuan, Mingguo Ma, Jiefang Zhu<br/>Human Vibration Energy Harvester with PZT / Tamil Selvan Ramadoss, Seeram Ramakrishna<br/>Energy Consumption in Information and Communication Technology: Role of Semiconductor Nanotechnology / Victor V Zhirnov, Kota VRM Murali<br/>Nanoenabled Materials and Coatings for Energy Applications. Nanocrystalline Bainitic Steels for Industrial Applications / C Garcia-Mateo, FG Caballero<br/>Graphene and Graphene Oxide for Energy Storage / Edward P Randviir, Craig E Banks<br/>Inorganic Nanotubes and Fullerene-Like Nanoparticles at the Crossroad between Materials Science and Nanotechnology and Their Applications with Regard to Sustainability / Leela S Panchakarla, Reshef Tenne<br/>Nanotechnology, Energy, and Fractals Nature / Vojislav V Mitić, Ljubiša M Kocić, Steven Tidrow, Hans-Jörg Fecht<br/>Magnesium Based Nanocomposites for Cleaner Transport / Manoj Gupta, Sankaranarayanan Seetharaman<br/>Nanocomposites: A Gaze through Their Applications in Transport Industry / Kottan Renganayagalu Ravi, Jayakrishnan Nampoothiri, Baldev Raj<br/>Semiconducting Nanowires in Photovoltaic and Thermoelectric Energy Generation / Guglielmo Vastola, Gang Zhang<br/>Nanoliquid Metal Technology Toward High-Performance Energy Management, Conversion, and Storage / Jing Liu<br/>IoNanofluids: Innovative Agents for Sustainable Development / Carlos Nieto de Castro, Xavier Paredes, Salomé Vieira, Sohel Murshed, Maria José Lourenço, Fernando Santos<br/>Energy Conservation and Management. Silica Aerogels for Energy Conservation and Saving / Yamini Ananthan, Keerthi Sanghamitra K, Neha Hebalkar<br/>Nanotechnology in Architecture / George Elvin<br/>Nanofluids for Efficient Heat Transfer Applications / Baldev Raj, SA Angayarkanni, John Philip<br/>Technologies, Intellectual Property, and Markets. Nanomaterials for Li-Ion Batteries: Patents Landscape and Product Scenario / Md Shakeel Iqbal, Nisha C Kalarickal, Vivek Patel, Ratnesh Kumar Gaur<br/>Nanotechnology in Fuel Cells: A Bibliometric Analysis / Manish Sinha, Ratnesh Kumar Gaur, Harshad Karmarkar<br/>Techno-Commercial Opportunities of Nanotechnology in Wind Energy / Vivek Patel, YR Mahajan<br/>Environmental Remediation. Nanomaterials for the Conversion of Carbon Dioxide into Renewable Fuels and Value-Added Products / Ibram Ganesh<br/>Nanomaterial-Based Methods for Cleaning Contaminated Water in Oil Spill Sites / Boris I Kharisov, HV Rasika Dias, Oxana V Kharissova, Yolanda Peña Méndez<br/>Nanomaterials and Direct Air Capture of CO2 / Dirk Fransaer.

::Summary## Nanotechnology progresses its concerts and suitability by improving its effectiveness, security and also reducing the impact and risk. Various chapters in this book are written by eminent scientists and prominent researchers in the field of nanotechnology across the world. This book is focused to put emerging techniques forward using nanoparticles for safe and nutritional food production, protecting crops from pests, increasing nutritional value and providing solutions for various environmental issues. The outcome of this book creates a path for wide usage of nanoparticles in food, agriculture and the environment fields. This book has clear and simple illustrations, tables and case studies to understand the content even by non-experts. This book especially deals with the nanotechnology for controlling plant pathogens, food packaging and preservation, agricultural productivity, waste water treatment and bioenergy production. Hence, this book can be adopted and used by many researchers and academicians in the fields of food, agriculture, environment and nanotechnology for catering the needs of sustainable future. The salient features of this book are • Describes nanotechnology as an interdisciplinary and emerging field in life sciences • Useful for researchers in the cutting edge life science related fields of nanoscience, nanobiology and nanotechnology • Deal with various problems in food, agriculture and environmental sector for sustainable solutions through the application of nanotechnology • Supported with illustrations in color, tables and case studies (wherever applicable), and • Contributed and well written by nanotechnology experts from across various disciplines.<br/>::Contents##<br/>Intro<br/>Preface<br/>Contents<br/>About the Editors<br/>Contributors<br/>Chapter 1: Nanoparticles from Fungal Resources: Importance and Applications<br/>1.1 Fungi<br/>1.2 Nanoparticles and Nanotechnology<br/>1.3 Properties of Nanoparticles<br/>1.3.1 Physical Properties<br/>1.3.2 Biological Properties<br/>1.3.3 Medical Properties<br/>1.3.4 Mechanical Properties<br/>1.3.5 Optical Properties<br/>1.3.6 Electrical Properties<br/>1.4 Classification of Nanoparticles<br/>1.5 Nanoparticles Synthesis<br/>1.6 Nanoparticle Synthesis by Fungal Resources<br/>1.6.1 Silver Nanoparticles (Ag-NPs) 1.6.2 Gold Nanoparticles (Au-NPs)<br/>1.6.3 Other Nanoparticles<br/>1.7 Applications of Nanoparticles<br/>1.7.1 Catalysis<br/>1.7.2 Wound Healing<br/>1.7.3 Textile Fabrics<br/>1.7.4 Vegetables and Food Preservation<br/>1.7.5 Molecular Detection<br/>1.8 Conclusion<br/>References<br/>Chapter 2: Nanoparticle-Incorporated Soy Protein Isolate Films<br/>2.1 Introduction<br/>2.2 Soy Protein<br/>2.3 Nanoparticles<br/>2.3.1 Non-functionalized/Absence of Reactive Moiety Nanoparticles<br/>2.3.2 Functionalized/Reactive Moiety Nanoparticles<br/>2.4 SPI as a Film 2.5 Structural and Reinforcement Effect of Nanoparticle in SPI Film<br/>2.5.1 FTIR<br/>2.5.2 Transmittance<br/>2.5.3 Water Uptake<br/>2.5.4 Mechanical Properties<br/>2.5.5 XRD<br/>2.5.6 SEM and TEM<br/>2.6 Mode of Interactions Between Nanoparticles and Soy Protein<br/>2.7 Antimicrobial Effects of Nanoparticles in Soy Protein Film<br/>2.8 Conclusion and Future Prospects<br/>References<br/>Chapter 3: Formulation, Characterization, and Potential Application of Nanoemulsions in Food and Medicine<br/>3.1 Introduction<br/>3.2 Types of Nanoemulsions<br/>3.3 Constituents of Nanoemulsions 3.4 Methodology for the Preparation of Nanoemulsions<br/>3.4.1 High-Energy Methods<br/>3.4.1.1 High-Pressure Homogenizer<br/>3.4.1.2 High Shear Stirring<br/>3.4.1.3 Ultrasonication Method<br/>3.4.1.4 Microfluidization<br/>3.4.2 Low-Energy Methods<br/>3.4.2.1 Spontaneous Nanoemulsions<br/>3.4.2.2 Phase Inversion Method<br/>3.4.2.3 Phase Inversion Temperature (PIT)<br/>3.4.2.4 Phase Inversion Composition (PIC)<br/>3.4.3 Bubble Bursting Method<br/>3.5 Firmness of Nanoemulsions<br/>3.6 Characterization of Nanoemulsions<br/>3.6.1 Morphology<br/>3.6.2 Size<br/>3.6.3 Zeta Potential (Surface Charge) 3.6.4 Polydispersity Index (PDI)<br/>3.6.5 Viscosity<br/>3.6.6 Refractive Index<br/>3.6.7 Dye Test<br/>3.6.8 Thermodynamic Stability<br/>3.6.8.1 Heating and Cooling Cycles<br/>3.6.8.2 Centrifugation<br/>3.6.8.3 Freeze and Thaw Cycles<br/>3.7 Application of Nanoemulsions<br/>3.7.1 Antimicrobial Nanoemulsions<br/>3.7.2 Preventive Agents Against Bioterrorism<br/>3.7.3 Disinfectant Cleaners<br/>3.7.4 Nanoemulsions in Delivery of Vaccine<br/>3.7.5 Nanoemulsions for Oral Delivery<br/>3.7.6 Nanoemulsions in Cell Culture<br/>3.7.7 Nanoemulsions as Ocular Drug Delivery

::Contents##<br/>Toxicological aspects for nanomaterial in humans<br/>Lactate dehydrogenase assay for assessment of polycation cytotoxicity<br/>Combined fluorimetric caspase 3/7 assay and bradford protein determination for assessment of polycation-mediated cytotoxicity<br/>Anti-PEG igm production via a PEGylated nano-carrier system for nucleic acid delivery<br/>Near-infrared optical imaging of nucleic acid nanocarriers in vivo<br/>Lipids for nucleic acid delivery: Synthesis and particle formation<br/>Histidine-rich cationic amphipathic peptides for plasmid DNA and siRNA delivery<br/>Synthesis of polyethylenimine-based nanocarriers for systemic tumor targeting of nucleic acids<br/>Synthesis of bioreducible polycations with controlled topologies<br/>Lyophilization of synthetic gene carriers<br/>Surface- and hydrogel-mediated delivery of nucleic acid nanoparticles<br/>Layer-by-layer assembled gold nanoparticles for the delivery of nucleic acids<br/>In situ AFM analysis investigating disassembly of DNA nanoparticles and nano-films<br/>Enhancing nucleic acid delivery with ultrasound and microbubbles<br/>Magnetic and acoustically active microbubbles loaded with nucleic acids for gene delivery<br/>Synthesis of lipidic magnetic nanoparticles for nucleic acid delivery<br/>Lipopeptide delivery of siRNA to the central nervous system<br/>Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery<br/>Liver-targeted gene delivery through retrograde intrabiliary infusion.

::Summary## Nanotechnology in Dermatology is the first book of its kind to address all of the important and rapidly growing aspects of nanotechnology as it relates to dermatology. In the last few years there has been an explosion in research and development for products and devices related to nanotechnology, including numerous applications for consumers, physicians, patients, and industry. Applications are underway in medicine and dermatology for the early detection, diagnosis, and targeted therapy of disease, and nanodesigned materials and devices are expected to be faster, smaller, more powerful, more efficient, and more versatile than their traditional counterparts. Written by experts working in this exciting field, Nanotechnology in Dermatology specifically addresses nanotechnology in consumer skin care products, in the diagnosis of skin disease, in the treatment of skin disease, and the overall safety of nanotechnology. The book also discusses future trends of this ever-growing and changing field, providing dermatologists, pharmaceutical companies, policy makers, and consumer cosmetics companies with a clear understanding of the advantages and challenges of nanotechnology today.<br/>::Contents##<br/>Formulating with Nanotechnology in Skin Care Opportunities and Challenges / Julian P. Hewitt B.A.<br/>Nanotechnology in Photoprotection / Lucy L. Chen B.A., Ian Tooley Ph.D., Steve Q. Wang M.D.<br/>Nanotechnology in Nail Care / Doug Schoon Ms<br/>Nanoscience on Shampoo and Conditioner / Peter D. Kaplan Ph.D.<br/>Nanotechnology-Based Fabrics / Roger Ronghua Wang Ph.D., Adnan Nasir M.D. Ph.D.<br/>Skin Penetration of Engineered Nanomaterials / Nancy A. Monteiro-Riviere Ph.D.<br/>Perspectives on Percutaneous Penetration of Nanomaterials / Mai A. Ngo Ph.D., Michael O'Malley, Howard I. Maibach M.D.<br/>Enhancement of Topical Delivery with Nanocarriers / Zoe Diana Draelos M.D.<br/>Hair Follicle Targeting with Nanoparticles / Fiorenza Rancan, Zahra Afraz, Behazine Combadiere<br/>Nano-Based Gene Therapy for Dermatologic Diseases / David L. Chen, Dan Zheng, Amy S. Paller<br/>Emerging Nanomedicine for Skin Cancer / Puiyan Lee, Adnan Nasir, Kenneth K. Y. Wong<br/>Nanotechnology and the Diagnosis of Cutaneous Malignancies / Julie K. Kim MD, Adnan Nasir MD, Kelly C. Nelson MD<br/>The Skin Immune System / Adnan Nasir M.D., Ph.D., Anthony Gaspari M.D.<br/>Diagnosis and the Skin Immune System / Adnan Nasir MD, PhD, Anthony Gaspari MD<br/>Augmenting the Skin Immune System / Adnan Nasir M.D., Ph.D., Anthony Gaspari M.D<br/>Nanoparticle-Based Epidermal and Dermal Vaccination / Angèle Soria, Annika Vogt, Adnan Nasir<br/>Suppressing the Skin Immune System / Adnan Nasir M.D., Ph.D., Anthony Gaspari M.D.<br/>Nanotechnology in the Treatment of Infectious Diseases / Adam Friedman M.D., FAAD, Karin Blecher M.D.<br/>Nanotechnology for the Histologic Diagnosis of Infectious Diseases: A Dermatopathologists Perspective / Dirk M. Elston MD<br/>Nanotechnology for the Diagnosis of Parasitic Infections / Fernando Sérgio Rodrigues Ribeiro Teles.

::Summary## Nanomedicine is the field of science that deals with organic applications of medicine at the nanoscale level. It primarily addresses finding, anticipating, and treating sickness, as well as using nanotechnology to assist in controlling human frameworks at the cellular level. The nature of nanotechnology allows it to address numerous medical issues in humans. This book offers comprehensive information to better comprehend and apply multifunctional nanoparticles in nanomedicine, and thus open avenues in the field. Medicating at the nanolevel is an exceptional therapeutic avenue, as it avoids symptoms associated with conventional medicines. This book investigates recent insights into structuring novel drug delivery frameworks. It concentrates on the physical characteristics of drug delivery transporters, and the preliminary procedures involved in their use. The book offers in-depth detail that benefits academics and researchers alike, containing broad research from experts in the field, and serves as a guide for students and researchers in the field of nanomedicine, drug delivery, and nanotechnology.<br/>::Contents##<br/>Preface<br/>Nanomedicine: General Introduction from A to Z<br/>Immunology and Nanotechnology: Effects and Affects<br/>Role of Nanotechnology in Sensor Development<br/>Nanotechnology in the Characterization of Cancer<br/>Nano Vaccine<br/>Nanotechnology in Theranostics and In Vivo Imaging<br/>The Implication of Physical and Chemical Characterization of Therapeutic and Imaging Applications<br/>Polymers in Nanomedicine<br/>Delivery of Drug Payloads to Organs and Organ-Systems of Human Beings<br/>Drug Delivery Towards Cancer<br/>Drug Delivery Towards Malaria<br/>Nanotechnology in Tissue Engineering and Implant Development<br/>Interactions Between Nano-Delivery Agents and Immune Systems<br/>The Fate of Drug Delivery Agents after Delivery of Payload<br/>Index.

::Summary## The book introduces the basic concepts of nanotechnology and the various technologies to characterize nanomaterials. It also covers the nanostructural features of mammalian cells/tissues and related nanomechanical properties. In addition, the book comprehensively describes the current state-of-the-art and future perspectives of nanotechnology in biosensors. It also discusses the potential of nanotechnology for delivering the diverse cancer therapeutics and illustrates its limitation due to the potential toxicity associated with oxidative stress. It also highlights the ethical issues and translational aspects related to nanotechnology. Finally, it summarizes the applications of nanotechnology in animal biotechnology, the recent perspectives and future challenges of nanomedicines. The content of the book are beneficial for the undergraduate, postgraduate and doctoral students as well the professionals working in the area of nanotechnology and nanomedicines.<br/>::Contents##<br/>Intro; Preface; Acknowledgements; Contents; About the Editors; Novel Therapeutics and Diagnostics Strategies Based on Engineered Nanobiomaterials; 1 Introduction; 2 Salient Features of Nanomaterials; 3 Biomedical Applications of Nanomaterials; 3.1 Bone Tissue Engineering; 3.2 Stem Cell Therapy; 3.3 Potential Therapeutics for Neurodegeneration; 3.4 Cancer Therapy; 3.5 Wound Healing Applications; 4 Drug Delivery; 4.1 Nano-emulsions; 4.2 Inorganic Nanoparticles; 4.2.1 Gold Nanoparticles (AuNPs); 4.2.2 Iron Oxide Nanoparticles (IONPs); 4.2.3 Silver Nanoparticles (AgNPs); 4.2.4 Quantum Dots (QDs) 1 Introduction1.1 Mechanism of siRNA Interference; 2 Advantages of siRNA; 2.1 Potency; 2.2 Selectivity; 2.3 Safe and Cheap Alternative; 3 Routes of Administration of siRNA; 3.1 Localized Delivery; 3.1.1 Topical Administration; 3.1.2 Ocular Administration; 3.1.3 Pulmonary Administration; 3.1.4 Gastrointestinal Administration; 3.1.5 Central Nervous System Administration; 3.1.6 Vaginal Administration; 3.2 Systemic Delivery; 3.2.1 Oral Administration; 3.2.2 Intravenous Administration; 3.2.3 Intraperitoneal Administration; 4 Major Hurdles to the Therapeutic Delivery of siRNA; 4.1 Transient Effect 3.2.2 Necrosis3.2.3 Secondary or Apoptotic Necrosis; 3.2.4 Factors Affecting Plasmonic Photothermal Therapy (PPTT); 3.2.5 Mechanism of Plasmonic Photothermal Therapy (PPTT); 4 Plasmonic Photothermal Therapy by Different Gold Nanostructures; 4.1 Gold Nanospheres; 4.2 Gold Nanorods (GNRs); 4.3 Gold Nanoshells (GNSs); 4.4 Gold Nanocages (GNCs) and Gold Nanorattles (GNRTs); 4.5 Gold Nanostars (GNSTs) and Gold Nanopopcorns (GNPs); 4.6 Gold Nanoaggregates; 5 Summary and Outlook; References; Nanomaterials-Based siRNA Delivery: Routes of Administration, Hurdles and Role of Nanocarriers 4.2 Stability4.3 Physiological Barriers; 4.4 Cellular Uptake and Endosomal Engulfing; 4.5 Off-Target Effect; 4.6 Saturation of RNAi Machinery; 4.7 Stimulation of Immune System by siRNAs; 5 Overcoming the Hurdles to siRNA Delivery Using Nanocarriers; 6 The Aid of Nanocarriers for siRNA Delivery; 6.1 Enhanced Blood Retention Time; 6.2 Enhanced Stability and Cell Penetration Property; 6.3 Site-Specific Delivery; 6.4 pH-Sensitive Trigger Release; 6.5 Avoid Intracellular Endosomal Engulfing; 7 Classification of Nanocarriers Used for Systemic Delivery of siRNA; 7.1 Organic Nanocarriers 5 Nanomaterials in Diagnostics5.1 Nanocomposites; 5.2 Nanoparticles; 5.3 Quantum Dots; 6 Conclusions and Future Prospective; References; Gold Nanostructures for Photothermal Therapy; 1 Introduction; 2 Types of Gold Nanostructures and Their Optical Properties; 2.1 Gold Nanospheres; 2.2 Gold Nanorods; 2.3 Gold Nanoshells; 2.4 Gold Nanocages and Nanorattles; 2.5 Gold Nanostars (GNSTs) and Gold Nanopopcorns (GNPs); 3 Mechanism of Heat Generation and Cell Death Induced by Plasmonic Photothermal Therapy (PTT); 3.1 Mechanism of Heat Generation; 3.2 Mechanism of Cell Death; 3.2.1 Apoptosis

::Summary## The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.<br/>::Contents##<br/>Intro<br/>Preface<br/>Contents<br/>Contributors<br/>Part I: Skin Infections<br/>Chapter 1: Nitric Oxide-Releasing Nanomaterials and Skin Infections<br/>1.1 Introduction<br/>1.2 NO and Human Skin<br/>1.3 Delivering NO to Human Skin<br/>1.4 Nanoparticles for Dermatological Applications<br/>1.4.1 Liposomes<br/>1.4.2 Polymeric Nanoparticles<br/>1.4.3 Metallic Nanoparticles<br/>1.5 NO-Releasing Nanomaterials for Biomedical Purposes<br/>1.5.1 NO-Releasing Nanoparticles in the Management of Skin Infection<br/>1.5.1.1 Bacterial Infections<br/>1.5.1.2 Fungal Infections<br/>1.5.1.3 Parasitic Infections 1.6 Conclusions<br/>References<br/>Chapter 2: Metal Nanoparticle Based Antibacterial Nanocomposites for Skin Infections<br/>2.1 Introduction<br/>2.2 Anatomy and Physicochemical Properties of Skin<br/>2.3 Type of Bacterial Infections in Skin<br/>2.4 Emergence of Various Types of Metal Nanoparticles (MNPs) and Its Composites<br/>2.5 Essences of New Class of Nanoscale Materials Suitable Against Skin Infections<br/>2.6 Nanoscale Materials as Antibacterial Skincare Agents<br/>2.6.1 Metal Nanoparticles<br/>2.6.1.1 Silver Nanoparticles (Ag NPs)<br/>2.6.1.2 Gold Nanoparticles (Au NPs)<br/>2.6.2 Metal Oxide NPs 2.6.2.1 Titanium Dioxide Nanoparticles<br/>2.6.2.2 Zinc Oxide Nanoparticles<br/>2.6.2.3 Copper Oxide Nanoparticles<br/>2.6.2.4 Other Metal Oxide Nanoparticles<br/>2.6.3 Nanocomposites<br/>2.7 Proposed Mathematical Models of Penetration of NPs Through Skin<br/>2.8 Diffusion of NPs Through Skin<br/>2.8.1 Mathematical Model for Diffusion Through Skin<br/>2.8.2 Metal and Metal Oxide NPs Diffusion Through Skin<br/>2.9 Conclusion<br/>References<br/>Chapter 3: Combination Therapy Using Metal Nanoparticles for Skin Infections<br/>3.1 Introduction<br/>3.2 Skin Infections<br/>3.3 Types of Skin Infections 3.3.1 Bacterial Skin Infections<br/>3.3.2 Fungal Skin Infections<br/>3.3.2.1 Athlete's Foot or Tinea pedis<br/>3.3.2.2 Jock Itch or Tinea cruris<br/>3.3.2.3 Ringworm or Tinea corporis<br/>3.3.2.4 Yeast Infections<br/>3.3.3 Viral Skin Infections<br/>3.3.3.1 Herpes Simplex Virus (HSV)<br/>3.3.3.2 Chickenpox (Varicella zoster)<br/>3.3.3.3 Shingle (Herpes zoster)<br/>3.3.3.4 Molluscum Contagiosum<br/>3.3.3.5 Measles and Rubella<br/>3.3.3.6 Hand-Foot-and-Mouth Disease<br/>3.3.3.7 Roseola<br/>3.3.3.8 Warts<br/>3.3.4 Parasitic Infections<br/>3.4 Metal and Metal Oxide Nanoparticles on Skin Infections 3.4.1 Silver Nanoparticles (AgNPs)<br/>3.4.2 Gold Nanoparticles (AuNPs)<br/>3.4.3 Copper Nanoparticles (CuNPs)<br/>3.4.4 Copper Oxide Nanoparticles (CuO NPs)<br/>3.4.5 Titanium Oxide Nanoparticles (TiO2 NPs) and Zinc Oxide Nanoparticles (ZnO NPs)<br/>3.5 Human Skin Penetration of Metallic Nanoparticles<br/>3.6 Combined Therapy of Metallic Nanoparticles in Bacterial Skin Infections<br/>3.7 Combined Therapy of Metallic Nanoparticles in Fungal Skin Infections<br/>3.8 Combined Therapy of Metallic Nanoparticles in Viral Skin Infections

::Summary## This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases. Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume, Nanotheranostics, Applications and Limitations, is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.<br/>::Contents##<br/>Nanotheranostics: An emerging nanoscience<br/>Green bionanomaterials: current status and future prospects in theranostics<br/>Current status and prospects of Chitosan-metal Nanoparticles and their applications as theranostic agents<br/>Aptamersnano complexes and aptamer based biosensors' role in ultrasensitive sensing<br/>Nanotheranostics Approaches In Antimicrobial Resistance<br/>Nanomaterials for selective targeting of intracellular pathogens<br/>Impact of nanoformulations on viruses and bacteria<br/>Theranostic potential of aptamers in antimicrobial chemotherapy<br/>Current and future aspects of nanotheranostics in cancer therapeutics<br/>Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Cancer Theranostic applications<br/>Theranostic applications of Nanobiotechnology in Cancer<br/>Aminolevulinic acid associated with nanotechnology for theranostic applications<br/>Non-viral targeted gene delivery for inflammatory disorder: applications and limitation.

::Summary## This book discusses the basics of nanotoxicity and gives a detailed account of methods used for toxicity evaluation of nanomaterials. It also gives indepth coverage of the effect of different types of nanomaterials, including organic and inorganic, on various aquatic animals, microorganisms and plants, and outlines recent challenges, regulatory frameworks and advances in nanotoxicity testing.<br/>::Contents##<br/>Preface<br/>Chapter 1. Introduction, Principles, and Concepts<br/>Chapter 2. Nanomaterials and Health<br/>Chapter 3. Safety and Utility of Nanomaterials on Reproduction and Development: an Update of Alternative Methods<br/>Chapter 4. Nano-Toxicity to Microbes: Potential Implications of Nanomaterials on Microbial Activity<br/>Chapter 5. Nanomaterials Causing Cellular Toxicity and Genotoxicity<br/>Chapter 6. Exploring Microbial Nanotoxicity Against Drug Resistance in Bacteria<br/>Chapter 7. Toxicity of Engineered Nanostructures in Aquatic Environments<br/>Chapter 8. In Vitro Methodologies For Toxicological Assessment Of Drug Delivery Nanocarriers<br/>Chapter 9. Impact Of Nanomaterials On The Food Chain<br/>Chapter 10. Phytoresponse to Nanoparticles Exposure<br/>Chapter 11. Environmental Impact and Econanotoxicity of Engineered Nanomaterials.

::Summary## This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs' translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.<br/>::Contents##<br/>Intro; Preface; Contents; <br/>Chapter 1: Values of C. elegans in Toxicological Study; 1.1 Introduction; 1.2 Raise of a Series of Useful Sublethal Endpoints for Toxicity Assessment of Environmental Toxicants; 1.3 High-Throughput Screen and Identification of Chemicals; 1.4 Toxicity Assessment of Environmental Toxicants Under Susceptible Genetic Backgrounds; 1.5 Toxicity Assessment of Environmental Toxicants at Environmentally Relevant Concentrations; 1.6 Understanding the In Vivo Physicochemical, Cellular, and Physiological Mechanisms of Toxicity Induced by Environmental Toxicants. 1.7 Elucidation of Toxicological Mechanisms of Environmental Toxicants in Certain Targeted Organs1.8 Elucidation of Underlying Molecular Mechanisms of Toxicity Induced by Environmental Toxicants; 1.9 Distribution and Translocation of Environmental Toxicants; 1.10 Confirmation of Chemical with Low-Toxicity or Non-Ưtoxicity Property; 1.11 Limitations of C. elegans in the Toxicological Study; References; <br/>Chapter 2: Endpoints for Toxicity Assessment of Nanomaterials; 2.1 Introduction; 2.2 Lethality; 2.3 Morphology and Development; 2.4 Reproduction. 2.4.1 Endpoints Assessing the Development of Reproductive Organs2.4.1.1 Germline Apoptosis; 2.4.1.2 Number of Apoptotic Cells per Gonad Arm Using CED-1::GFP Transgenic Strain; 2.4.1.3 Assay of DNA Damage Using HUS-1::GFP Transgenic Strain; 2.4.1.4 Assay of 40,6-Diamidino-2-Phenylindole (DAPI) Staining; 2.4.2 Endpoints Assessing the Function of Reproductive Organs; 2.4.2.1 Brood Size; 2.4.2.2 The Number of Oocytes; 2.4.2.3 Egg Ejection; 2.4.2.4 Embryonic Lethality; 2.4.3 Reproduction of Male Nematodes; 2.4.3.1 Male Formation Assay; 2.4.3.2 Abnormal Male-Specific Structures. 2.5 Neuronal Development and Function2.5.1 Neuronal Development; 2.5.1.1 Analysis of Axonal Degeneration and Neuronal Loss of D-Type GABAergic Motor Neurons; 2.5.1.2 Fluorescent Images of Certain Neurons; 2.5.2 Neuronal Function; 2.5.2.1 Movement Speed; 2.5.2.2 Locomotion Behavior; 2.5.2.3 Thermotaxis Perception and Thermotaxis Learning Assays; 2.5.2.4 Foraging Behavior Assay; 2.5.2.5 Shrinking Behavior Assay; 2.5.2.6 Neurotransmission; 2.6 Intestinal Development and Function; 2.6.1 Intestinal Development. 2.6.1.1 Analysis of Intestinal Development Based on Transmission Electron Microscopy (TEM) Assay2.6.1.2 Analysis of Expression Patterns of Genes Required for the Control of Intestinal Development; 2.6.2 Intestinal Function; 2.6.2.1 Intestinal Reactive Oxygen Species (ROS) Production; 2.6.2.2 Intestinal Permeability; 2.6.3 Defecation Behavior; 2.6.3.1 Defecation Behavior; 2.6.3.2 Analysis and Fluorescent Images of Neurons Controlling the Defecation Behavior; 2.6.3.3 Analysis of Expression Patterns of Genes Required for the Control of Defecation Behavior; 2.7 Epidermal Development.

::Summary## Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex matrices such as food products, leading to secondary features potentially more relevant than primary characteristics for determining their toxicological outcome. These nano specific issues raise the question of whether the NMs may produce adverse outcomes that are not accounted for when using conventional toxicological approaches to assess their safety. Such uncertainties about the safety of NMs for human health and the environment may hamper a faster and more widespread exploration of their potentials. In response, the NMs definition has evolved, and nanotoxicology has developed towards new and more integrative approach methods to support regulatory and policy actions. This book provides a perspective on recent developments in the synthesis, application, and characterization of NMs and the related nanotechnologies, focusing on nanotoxicology for their accurate safety assessment early in the product development stage. The use of complex in vitro models, including multicellular systems and organoids, and "omics-based" approaches, such as transcriptomics or epigenomics, have greatly contributed to an in-depth understanding of the cellular and molecular mechanisms behind some NMs toxicity. Such mechanistic knowledge is equally addressed in this book and has set the basis for a predictive nanotoxicology approach building on adverse outcome pathways. In addition, considering the knowledge provided by the above-mentioned approaches, insights into risk assessment, standardization, and regulation of NMs are also included. Incorporating adequate nanosafety assessment early in the life-cycle of NMs will allow the implementation of the safe and sustainable-by-design paradigm enabling safety to keep pace with innovation. Chapters 10 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.<br/>::Contents##<br/>Part I: Nanotechnologies: Synthesis, application and characterization of nanomaterials<br/>Chapter 1. Challenges in Nanomaterial Characterization From Definition to Analysis (Jose Catita)<br/>Chapter 2.Trends in the design and evaluation of polymeric nanocarriers: the in vitro nano-bio interactions (Ana Bettencourt, Lidia Goncalves)<br/>Chapter 3. LipNanoCar technology - A versatile and scalable technology for the production of lipid nanoparticles (Vera L.R. Esgueira, Clara P.A. Lopes, Ana Catarina A. dos Santos, Fatima C.R.V. Pinto, Silvia A. Sousa, Dragana P.C. de Barros, Jorge H. Leitao, Luis P. Fonseca)<br/>Chapter 4. Dermal delivery of lipid nanoparticles: Effects on skin and assessment of absorption and safety (Fatima Pinto, Luis P. Fonseca, Dragana P.C. de Barros)<br/>Chapter 5. Targeting cancer by using nanoparticles to modulate Rho GTPase signalling (Paulo Matos, Joana F. S. Pereira and Peter Jordan)<br/>Chapter 6. Nanocelluloses: production, characterization and market (Paulo J. T. Ferreira, Ana F. Lourenco)<br/>Part II: Nanotoxicology: concepts and methodologies for toxicity evaluation of the nanomaterials<br/>Chapter 7. Nanotoxicology assessment and safety aspects of nanocelluloses for 3D bioprinting applications (Gary Chinga-Carrasco, Jennifer Rosendahl, and Julia Catalan)<br/>Chapter 8. New "omics" approaches as a tool to explore mechanistic nanotoxicology (Celia Ventura, Vukosava Torres, Luis Vieira, Bruno Gomes, Antonio Sebastiao Rodrigues, Jose Rueff, Deborah Penque, Maria Joao Silva)<br/>Chapter 9. Epigenetic mechanisms in understanding nanomaterial-induced toxicity (Manosij Ghosh, Lode Godderis, Peter Hoet)<br/>Chapter 10. Cellular and molecular mechanisms of toxicity of ingested nanomaterials (Adriana Vieira, Ana Gramacho, Dora Rolo, Nadia Vital, Maria Joao Silva, Henriqueta Louro)<br/>Chapter 11. Nanomaterial-induced extra-pulmonary health effects - the importance of next generation physiologically relevant in vitro test systems for the future of nanotoxicology (Ali Kermanizadeh, Gwyndaf Roberts)<br/>Chapter 12. Drosophila as a suitable in vivo model in the safety assessment of nanomaterials (Esref Demir, Fatma Turna Demir, and Ricard Marcos)<br/>Chapter 13. Toxicological aspects of iron oxide nanoparticles (Natalia Fernandez-Bertolez,b, Carla Costa, Fatima Brandao, Joao Paulo Teixeira, Eduardo Pasaro, Vanessa Valdiglesias, Blanca Laffon)<br/>Chapter 14. Hazard assessment of benchmark metallic nanomaterials through a set of in vitro genotoxicity assays (Nadia Vital, Mariana Pinhao, Naouale El Yamani, Elise Ruden-Pran, Henriqueta Louro, Maria Dusinska, Maria Joao Silva)<br/>Part III: Towards the risk assessment and regulation of nanomaterials<br/>Chapter 15. Nanomaterials, a new challenge in the workplace (Ana Rita Alberto, Cristina Matos, Gabriel Carmona-Aparicio, Muriel Iten)<br/>Chapter 16. Nanomaterials in foods and human digestion: an important layer in the assessment of potential toxic effects (Carla Martins, Paula Alvito, Ricardo Assuncao)<br/>Chapter 17. Adverse Outcome Pathways (AOPs) development, a tool for predictive nanotoxicology (Dora Rolo, Ana Tavares, Nadia Vital, Maria Joao Silva and Henriqueta Louro).

::Contents##<br/>Section I<br/>Etiology<br/>1. The Genetics of Narcolepsy<br/>2. Orexin (Hypocretin) and Narcolepsy<br/>3. Precipitants of Narcolepsy: Vaccines and Infections<br/>Section II<br/>Clinical Considerations<br/>4. Epidemiology of Narcolepsy<br/>5. Diagnostic Criteria and Delay in Diagnosis of Narcolepsy<br/>6. Narcolepsy in Childhood<br/>7. Narcolepsy in the Older Adult<br/>8. Hypnagogic Hallucinations and Sleep Paralysis<br/>9. Symptomatic Narcolepsy or Hypersomnia, with and without Hypocretin (Orexin) Deficiency<br/>10. Hypersomnias Other than Narcolepsy: Differential Diagnosis<br/>11. Narcolepsy and Other Comorbid Medical Illnesses<br/>12. Sleep Disorders Comorbidities in Narcolepsy and their Management<br/>13. Neuroimaging of Narcolepsy<br/>Section III<br/>Psychosocial Considerations<br/>14. Quality of Life and Psychosocial Issues in Narcolepsy: Implications for Management<br/>15. Narcolepsy, Intimacy and Sexuality<br/>16. Memory and Cognition in Narcolepsy<br/>17. Psychoanalysis and Narcolepsy<br/>18. Dreaming in Narcolepsy<br/>19. Narcolepsy and Mental Illness<br/>20. Narcolepsy, Driving and Traffic Safety<br/>Section IV<br/>Management<br/>21. Overview of Management of Narcolepsy<br/>22. Modes of Action of Drugs Related to Narcolepsy: Pharmacology of Wake-Promoting Compounds and Anticataplectics<br/>23. Modafinil/Armodafinil in the Treatment of Narcolepsy<br/>24. Sodium Oxybate in the Treatment of Narcolepsy<br/>25. Pregnancy and Anaesthesia in Narcolepsy<br/>26. Emerging Treatments for Narcolepsy<br/>27. Behavioral and Non-Pharmacological Management of Narcolepsy<br/>Section V<br/>Health Care Delivery and Medico-Legal Considerations<br/>28. Narcolepsy and Developmental Disability<br/>29. Succeeding in School and in the Workplace with Narcolepsy<br/>30. Medico-Legal Aspects of Disability in Narcolepsy<br/>31. The Affordable Care Act and the Future of Sleep Medicine.

::Contents##<br/>Introduction<br/>Narrating patienthood: voicing, empowering, advocating<br/>Narratives of patient experience<br/>From stories to discoveries<br/>Cultural communication competency as a two-way street<br/>If I die, who will tell their stories?<br/>Narrating patienthood: differences that matter<br/>African Americans and hospice care<br/>"Can you please direct me to a doctor that has a heart?"<br/>Exploring the effects of patient-provider communication on the lives of women with vulvodynia<br/>Queer patienthood<br/>An autoethnographic account of navigating patienthood as a person with hearing impairment<br/>Narrating patienthood: intersections of communication and the personal, relational, professional, and cultural<br/>From consumer to community-based researcher<br/>The gendered nature of generosity in post-hysterectomy "dear honey" letters<br/>The narrative journey and decision-making process of plastic surgery patienthood<br/>Narrative sense-making in systemic lupus erthematosus<br/>Healthy mother, healthy baby<br/>Ableist Biases<br/>Index<br/>About the contributors.

::Summary## "This second edition features a new collection of thirty-two essays previously published in the Narrative Matters section of the journal Health Affairs in recent years. As in the first edition, the essays are divided into topical areas such as the doctor-patient relationship, health care delivery and reform, care for aging patients, and the opioid crisis. The book could be adopted for courses on medical humanities or narrative medicine. The essays are written by some of the leading popular writers in health care today"-- Provided by publisher.<br/>::Contents##<br/>The practice of medicine<br/>Medical innovation and research<br/>Patient-centered care<br/>The doctor-patient relationship<br/>Disparities and discrimination<br/>Aging and end-of-life care<br/>Maternity and childbirth<br/>Opioids and substance abuse.

::Contents##<br/>Evidence-based medicine and narrative medicine: a harmonic couple<br/>Bridging from mythology to contemporary care: the art of listening<br/>Bridging from oral tradition to writing: the art of empathy<br/>The Tower of Babel: the language of physicians, patients, and providers of care<br/>Patient's narrative as a probe for successful coping<br/>The muted desire for well-being and the abuse of the word "normality" in medicine<br/>Bridging the gap between personalization of care and research<br/>The place of illness-centred movies in medical humanities<br/>Designing health care based on patient's needs and rights<br/>Building a bridge between economic investment and medical humanities: the fears to overcome<br/>A selection of narratives<br/>Glossary: a tool to bridge the gap between medical humanities, medical science, health-care organization, and health-care economics.

::Summary## Nasal physiology and pathophysiology is a relatively neglected area, yet without a deep knowledge of the physiology it is impossible to understand the impact of structural changes and the process of disease development or to make sound treatment decisions. With the help of numerous tables, schematic drawings, and color photographs, this book will enable the reader to understand the nasal physiology and pathophysiology in detail. All four functions of the nose -- respiration, defense, olfaction, and cosmesis -- are covered. Each chapter addresses one important aspect in an accessible way, and each is written by an acknowledged expert on the topic under consideration. The various techniques of clinical evaluation of nasal function are fully discussed, and current trends and future directions in nasal physiologic research are also explored. This book will be of value to both practicing otorhinolaryngologists and novices in the field.<br/>::Contents##<br/>Mucus, Goblet Cell, Submucosal Gland<br/>Cilia, Ciliary Movement, and Mucociliary Transport<br/>Functional Defense Mechanisms of the Nasal Respiratory Epithelium<br/>Local Nasal Infl ammation: T Cells and B Cells<br/>Mast Cells<br/>Macrophage<br/>The Neutrophil and Chronic Rhinosinusitis<br/>The Role of Eosinophils in Rhinologic Diseases<br/>Nasal NO and Its Role in the Physiology of the Nose and Diagnosis<br/>Olfaction<br/>Physiology and Pathophysiology of Sneezing and Itching: Mechanisms of the Symptoms<br/>The Dry Nose<br/>Physiology of the Aging Nose and Geriatric Rhinitis<br/>Nutrition and the Upper Respiratory Tract<br/>Nose as a Route for Drug Delivery<br/>Physiology of Lacrimal Drainage<br/>Intranasal Trigeminal Perception<br/>Sinus Pain<br/>Computational Fluid Dynamics of the Nasal Cavity<br/>Physiology and Pathophysiology of Nasal Breathing<br/>Function of the Turbinates: Nasal Cycle<br/>The Nasal Valves<br/>Nose and Sleep Breathing Disorders<br/>Pathophysiology of Obstructive Sleep Apnea<br/>Physiology: Rhinomanometry<br/>Acoustic Rhinometry<br/>New Measurement Methods in the Diagnostic of Nasal Obstruction<br/>Testing of Transport, Measurement of Ciliary Activity<br/>Nasal Defensive Proteins: Distribution and a Biological Function<br/>Assessment of Olfactory Function<br/>Electron Microscopy and the Nose<br/>Genetic Background of the Rhinologic Diseases<br/>Vomeronasal Organ<br/>Physiology of the Nasal Cartilages and Their Importance to Rhinosurgery<br/>Physiology and Pathophysiology of the Growing Nasal Skeleton<br/>Physiologic Concerns During Rhinoplasty<br/>Nasal Pulmonary Interactions<br/>Physiologic and Dentofacial Effects of Mouth Breathing Compared to Nasal Breathing<br/>Nanomedicine and the Nose<br/>The Nose and the Eustachian Tube.

::Summary## This book provides up-to-date guidance that will assist radiation oncologists during the day-to-day management of nasopharyngeal cancer. After discussion of diagnosis and staging, target delineation techniques and treatment planning are described for both intensity-modulated and particle radiation therapy. Detailed information is then presented on the application of radiation therapy in different disease settings, from early stage disease to metastatic disease. Due attention is paid to the role of multimodality treatment and new and advanced technologies in particular circumstances, such as local recurrence. In addition, follow-up and the management of late toxicities are explained and management strategies are documented for special situations and groups, including pediatric patients. The book is published within the Springer series Practical Guides in Radiation Oncology. Like other volumes in the series, it is designed for hands-on use by both radiation oncology residents and practicing radiation oncologists. It will also be of value for head and neck physicians.<br/>::Contents##<br/>1.Diagnosis Staging of Nasopharyngeal Cancer<br/>2.Contouring Methods and Atlas of Organs at Risk<br/>3.Management of neck disease in early stage disease<br/>4.Multimodality Management for Locally Advanced Nasopharyngeal Cancer<br/>5.Intesity-modulated radiation therapy for Nasopharyngeal Cancer<br/>6.Particle beam radiation therapy for Nasopharyngeal Cancer<br/>7.Treatment of Metastatic Nasopharyngeal Cancer<br/>8.Salvage radiation therapy for locally recurrent Nasopharyngeal Cancer<br/>9.The Use of the EBV Blood Test in Clinical Management Decision<br/>10.Management of Radiotherapy Induced Acute Toxicities<br/>11.Management of Radiation-induced Late Complications and Evidence-based Surveillance for Nasopharyngeal Carcinoma<br/>12.Special Consideration in Pediatric Nasopharyngeal Cancer.

::Contents##<br/>Diagnosis and clinical evaluation of nasopharyngeal carcinoma / Alan Soo-Beng Khoo and Kin-Choo Pua<br/>Histopathological diagnosis of nasopharyngeal carcinoma : looking beyond the blue book / John Nicholls and Gerald Niedobitek<br/>Descriptive, environmental and genetic epidemiology of nasopharyngeal carcinoma/<br/>Bing-jian feng<br/>Epstein-Barr virus and the pathogenesis of nasopharyngeal carcinomas / Claire Gourzones, Pierre Busson and Nancy Raab-Traub<br/>Acquired genetic and epigenetic alterations in nasopharyngeal carcinoma / Kwok-Wai Lo, Grace Tin-Yun Chung and Ka-Fai To<br/>Cellular interactions in nasopharyngeal carcinomas / Claire Gourzones ... [et al.]<br/>Biological tools for NPC population screening and disease monitoring / Claire Gourzones ... [et al.]<br/>Medical imaging of nasopharyngeal carcinomas : current tools and applications / François Bidault<br/>Radiotherapy of NPC : current strategies and perspectives / John Kim<br/>The evolving role of systemic therapy in nasopharyngeal carcinoma : current strategies and perspectives / Edwin P. Hui and Anthony T.C. Chan<br/>Nasopharyngeal carcinoma immunotherapy current strategies and perspectives / Corey Smith and Rajiv Khanna<br/>Therapeutic induction of apoptosis in nasopharyngeal carcinoma / Carlo Bastianutto ... [et al.].

::Contents##<br/>Nasopharyngeal carcinoma : management strategies / Sue S. Yom & Joseph Wee<br/>Epidemiology of nasopharyngeal carcinoma / Yoke Lim Soong & Ivan Weng Keong Tham<br/>Nasopharyngeal carcinoma : imaging / Eric Y.S. Ting, Chih Ching Choong & Vincent F.H. Chong<br/>Nasopharyngeal cancer staging / John Kim<br/>Early-stage nasopharyngeal carcinoma / Henry CK Sze, Ka On Lam & Anne W.M. Lee<br/>Management of locally and regionally advanced nasopharyngeal carcinoma with chemoradiotherapy / Benjamin H. Lok & Nancy Y. Lee<br/>Management of the node negative neck in early-stage nasopharyngeal carcinoma / Francis C.H. Ho & Jiade J. Lu<br/>Nasopharyngeal carcinoma : staging work-up and surveillance / Azita S. Khorsandi & Kenneth Hu<br/>Oligometastatic disease / Amy T.Y. Chang, Oscar S.H. Chan, Simon S. Lo & Wai Tong Ng<br/>Salvage treatment for local recurrence / Dora L.W. Kwong & Jimmy Y.W. Chan<br/>Nasopharyngeal carcinoma : distant metastasis / Wu-Meng Tan & Darren Wan-Teck Lim<br/>Epstein-Barr virus diagnostic and therapeutic opportunities in nasopharyngeal carcinoma / Radha Raghupathy, Edwin Pun Hui & Anthony T.C. Chan<br/>Emerging molecular targets in the treatment of nasopharyngeal carcinoma / Herbert H. Loong & Lillian L. Siu<br/>Survivorship and quality of life after treatment for nasopharyngeal cancer / Minh Tam Truong<br/>Ask the experts : maximizing the therapeutic ratio in the treatment of nasopharyngeal carcinoma / Sue S. Yom & Joseph Wee<br/>Multiple choice questions : answers.

::Contents##<br/>Nasal anatomy / Alfonso García-Piñero, Eugenio Cárdenas, Ariel Kaen, Juan Antonio Simal-Julian<br/>Nasal physiology / Jonathan Frankel, Emily Hrisomalos, Steven M. Houser<br/>Nasal septum and nasal wall vascularization / Juan R. Gras-Cabrerizo, Juan Ramón Gras Albert, Elena Garcia-Garrigós, Humbert Massegur-Solench<br/>Nasal perforation etiology / Mauricio López-Chacón, Arturo Cordero Castillo, Cristobal Langdon, Francesca Jaume, Isam Alobid<br/>Systemic diseases associated with septal perforation / Mauricio López-Chacón, Arturo Cordero Castillo, Cristobal Langdon, Alfonso Santamaría, Isam Alobid<br/>Preoperative clinical evaluation of patient / Fabio Ferreli, Paolo Castelnuovo<br/>Conservative treatment / Arturo Cordero Castillo, Mauricio López-Chacón, Cristobal Langdon, Isam Alobid<br/>Nasal perforation and septal prosthesis / Meritxell Valls, Alfonso Santamaría, Isam Alobid<br/>Free grafts / Hesham A.K.A. Mansour<br/>Repair of nasal septal perforation by using middle turbinate flap / Deniz Hanci, Huseyin Altun<br/>Inferior turbinate flap / Cristobal Langdon, Isam Alobid<br/>Lateral nasal wall flap / Cristobal Langdon, Mauricio López-Chacón, Arturo Cordero Castillo, Alfonso Santamaría, Paula Mackers, Isam Alobid<br/>Anterior ethmoidal artery septal flap / Paolo Castelnuovo, Fabio Ferreli, Pietro Palma<br/>Unilateral mucosal advancement flap / Jung Soo Kim, Sung Jae Heo<br/>Bilateral cross-over flap technique / Shirley Shizue Nagata Pignatari, Aldo Cassol Stamm, Leonardo Balsalobre<br/>Bilateral septal mucosal flaps in septal perforations / José J. Letort<br/>Unilateral nasal floor and inferior meatus flap / Meritxell Valls Mateus, Cristobal Langdon, Isam Alobid<br/>Facial artery musculomucosal flap / Tareck Ayad, Philippe Lavigne, Ilyes Berania<br/>'Slide and patch' technique / Michele Cassano<br/>Backward extraction-reposition technique of quadrangular cartilage / Ignazio Tasca, Giacomo Ceroni Compadretti<br/>Pericranial flap and endoscopic septal repair / Alfonso Santamaría, Cristobal Langdon, Mauricio López-Chacón, Arturo Cordero Castillo, Isam Alobid<br/>Quality of life / Fabio Ferreli, Paolo Castelnuovo<br/>Endoscopic repair for septal perforation : algorithm / Fabio Ferreli, Paolo Castelnuovo.

::Contents##<br/>Anatomy and physiology of hematopoiesis<br/>The neonatal erythrocyte and its disorders<br/>Immune hemolytic disease<br/>Neonatal jaundice and disorders of bilirubin metabolism<br/>Hemostasis in the newborn and infant<br/>Acquired aplastic anemia and pure red cell aplasia<br/>Inherited bone marrow failure syndromes<br/>Principles of bone marrow and stem cell transplantation<br/>Diagnostic approach to the anemic patient<br/>Megaloblastic anemia<br/>Disorders of iron and copper metabolism, the sideroblastic anemias, and lead toxicity<br/>Porphyrias<br/>Autoimmune hemolytic anemia<br/>Paroxysmal nocturnal hemoglobinuria<br/>Red cell membrane<br/>Disorders of the red cell membrane<br/>Pyruvate kinase deficiency and disorders of glycolysis<br/>Glucose-6-phosphate dehydrogenase deficiency<br/>Normal and abnormal hemoglobins<br/>Sickle cell disease<br/>Thalassemias<br/>Phagocyte system and disorders of granulopoiesis and granulocyte function<br/>Immune response<br/>Primary immunodeficiency diseases<br/>Lysosomal storage diseases<br/>Platelets and the vessel wall<br/>Blood coagulation<br/>Molecular basis of fibrinolysis<br/>Approach to the child with a suspected bleeding disorder<br/>Inherited platelet disorders<br/>Hemophilia and von Willebrand disease<br/>Rare hereditary coagulation factor abnormalities<br/>Inherited disorders of thrombosis and fibrinolysis<br/>Acquired platelet defects<br/>Acquired disorders of hemostasis<br/>Transfusion medicine<br/>Hematologic manifestations of systemic diseases<br/>Hematologic manifestations of systemic diseases in children of the developing world<br/>Origins and evolution of pediatric cancers<br/>Epidemiology of leukemia in childhood<br/>Informatics<br/>Genetic predisposition to cancer<br/>Genetics and epigenetics of childhood cancers<br/>Targeted therapies in oncology<br/>Cytogenetic and molecular pathology of pediatric cancer<br/>Cancer chemotherapy for pediatric patients<br/>Immunotherapy of cancer<br/>Pediatric radiation oncology<br/>Pediatric surgical oncology<br/>Acute lymphoblastic leukemia<br/>Pediatric myeloid leukemia, myelodysplasia, and myeloproliferative disease<br/>Infant leukemias<br/>Pediatric lymphoma<br/>Neuroblastoma<br/>Pediatric renal tumors<br/>Retinoblastoma<br/>Tumors of the brain and spinal cord<br/>Hepatoblastoma and other liver tumors in children<br/>Rhabdomyosarcoma<br/>Nonrhabdomyosarcoma soft tissue sarcomas and other soft tissue tumors<br/>Ewing sarcoma<br/>Osteosarcoma<br/>Pediatric germ cell tumors<br/>Histiocytoses<br/>Rare tumors of childhood<br/>Imaging in the evaluation and management of childhood cancer<br/>Infectious disease in the pediatric cancer patient<br/>Oncologic emergencies<br/>Nursing care of patients with childhood cancer<br/>Palliative care in pediatric oncology<br/>Symptom management in children with cancer<br/>Childhood cancer survivorship<br/>Psychosocial care of the child and family<br/>Ethical considerations in pediatric oncology clinical trials<br/>Reference values in infancy and childhood.

::Summary## "This manual serves as a step-by-step practical reference to support countries in building capacity for integrating health inequality monitoring into their health information systems. It presents a range of World Health Organization tools and resources developed for measuring and reporting health inequality"--Publisher's description.<br/>::Contents##<br/>Determine scope of the monitoring<br/>Obtain data<br/>Analyse data<br/>Report results<br/>Implement changes.

::Contents##<br/>Overview of kidney function and structure<br/>Kidney development<br/>Assessment of glomerular filtration rate in acute and chronic settings<br/>Urinalysis and urine microscopy<br/>Hematuria and proteinuria<br/>Kidney imaging<br/>Hyponatremia and hypoosmolar disorders<br/>Hypernatremia<br/>Edema and the clinical use of diuretics<br/>Disorders of potassium metabolism<br/>Disorders of mineral matabolism: calcium, phosphorus, and magnesium<br/>Approach to acid-base disorders<br/>Metabolic acidosis<br/>Metabolis alkalosis<br/>Respiratory acidosis and alkalosis<br/>Glomerular clinicopathologic syndromes<br/>Minimal change disease<br/>Focal segmental glomerulosclerosis<br/>Membranous nephropathy<br/>Immunoglobulin A nephropathy and related disorders<br/>Goodpasture syndrome and other antiglomerular basement membrane diseases<br/>Postinfectious glomerulonephritis<br/>Kidney involvement in systemic vasculitis<br/>Kidney manifestations of systemic lupus erythematosus<br/>Pathogenesis, pathophysiology, and treatment of diabetic nephropathy<br/>Dysproteinemias and amyloidosis<br/>Thrombotic microangiopathies<br/>Viral nephropathies: human immunodeficiency virus, hepatitis C virus and hepatitis B virus<br/>Acute cardiorenal syndrome<br/>Hepatorenal syndrome and other liver-related kidney deseases<br/>Kidney incancers<br/>Pathophysiology of acute kidney injury<br/>Clinical approach to the diagnosis of acute kidney injury<br/>Acute tubular injury and tubular necrosis<br/>Acute interstitial nephritis<br/>Management of acute kidney injury<br/>Kidney disease causes by therapeutic agents<br/>Principles of drug therapy in patients with reduced kidney function<br/>Genetically based renal transport disorders<br/>Sickle cell nephropathy<br/>Polycystic and other cystic kidney diseases<br/>Nephronophthisis and medullary cystic kidney disease<br/>Alport syndrome and related disorders<br/>Fabry diseases<br/>Chronic tubulointerstitial disease<br/>Obstructive uropathy<br/>Nephrolithiasis<br/>Urinary tract infection and pylenonephritis<br/>Kidney in infants and children<br/>Kidney in pregnancy<br/>Kidney disease in the elderly<br/>Pathophysiology of chronic kidney diseases<br/>Staging and management of chronic kidney disease<br/>Nutrition and kidney diseases<br/>Bone disorders in chronic kidney disease<br/>Cardiac function and cardiovascular disease in chronic kidney disease<br/>Anemia and other hematologic complications of chronic kidney disease<br/>Hemodialysis<br/>Peritoneal dialysis<br/>Outcomes of kidney replacement therapies<br/>Selection of prospective kidney transplant recipients and donors<br/>Posttransplantation monitoring and oucomes<br/>Immunosuppression in transplantation<br/>Infectious complications of kidney transplantation<br/>Pathogenesis of hypertension<br/>Evaluation and management of hypertension<br/>Secondary hypertension.

::Summary## "Ideal for residency, fellowship, clinical practice, and board review, the National Kidney Foundation's Primer on Kidney Diseases, 7th Edition, by Drs. Scott J. Gilbert and Daniel E. Weiner, offers comprehensive coverage of adult and pediatric kidney diseases in an authoritative, practical resource. Well organized and highly readable, it covers every relevant topic in the field, from anatomy, physiology, and pathophysiology, to diagnosis and management of kidney disease, to fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation"--Publisher's description.<br/>::Contents##<br/>Structure and function of the kidney. Overview of kidney structure and function<br/>Kidney development<br/>Assessment of kidney function in acute and chronic settings<br/>Urinalysis and urine microscopy<br/>Hematuria and proteinuria<br/>Imaging the kidneys<br/>Acid/base and electrolytes. Hyponatremia and hypoosmolar disorders<br/>Hypernatremia<br/>Volume, edema and the clinical use of diuretics<br/>Disorders of potassium metabolism<br/>Disorders of calcium, phosphorus, & magnesium homeostasis<br/>Approach to acid-base disorders<br/>Metabolic acidosis<br/>Metabolic alkalosis<br/>Respiratory acidosis and alkalosis<br/>Glomerular diseases. Glomerular clinicopathologic syndromes<br/>Minimal change nephrotic syndrome<br/>Focal segmental glomerulosclerosis<br/>Membranous nephropathy<br/>Immunoglobulin a nephropathy and related disorders<br/>Kidney in systemic diseases. Complement-mediated glomerulonephritis and thrombotic microangiopathy<br/>Infection-related glomerulonephritis<br/>Viral nephropathies: human immunodeficiency virus, hepatitis c virus, and hepatitis B virus<br/>Kidney involvement in systemic vasculitis<br/>Systemic lupus erythematosus and the kidney<br/>Pathogenesis, pathophysiology, and treatment of diabetic nephropathy<br/>The kidney in malignancy<br/>Myeloma, amyloid and other dysproteinemias<br/>Acute cardiorenal syndrome<br/>Hepatorenal syndrome and other liver-related kidney diseases<br/>Acute kidney injury. Clinical approach to the diagnosis of acute kidney injury<br/>Acute tubular injury and acute tubular necrosis<br/>Acute interstitial nephritis<br/>Management of acute kidney injury<br/>Drugs and the kidney. Kidney disease caused by therapeutic agents<br/>Principles of drug therapy in patients with reduced kidney function<br/>Hereditary kidney disease. Genetics and kidney disease (APOL1)<br/>Genetically based renal transport disorders<br/>Sickle cell nephropathy<br/>Polycystic and other cystic kidney diseases<br/>Nephronophthisis and medullary cystic kidney disease<br/>Alport's syndrome and thin basement membrane Dz<br/>Fabry disease<br/>Tubulointerstitial diseases. Chronic tubulointerstitial disease<br/>Obstructive uropathy<br/>Nephrolithiasis<br/>Urinary tract infection and pyelonephritis<br/>Special circumstances. Kidney diseases in infants and children<br/>The kidney in pregnancy<br/>Kidney disease in the elderly<br/>Global kidney disease<br/>Chronic kidney disease. Development and progression of chronic kidney disease<br/>Staging and management of chronic kidney disease<br/>Nutrition and kidney disease<br/>Bone disorders in chronic kidney disease<br/>Cardiac function and cardiovascular disease in chronic kidney disease<br/>Anemia and other hematologic complications of chronic kidney disease<br/>Dialysis and transplantation. Hemodialysis and hemofiltration<br/>Peritoneal dialysis<br/>Outcome of end-stage renal disease therapies<br/>Selection of prospective kidney transplant recipients and donors<br/>Post-transplantation monitoring and outcomes<br/>Immunosuppression<br/>Transplant infectious disease<br/>Hypertension. Pathogenesis of hypertension<br/>Evaluation and management of hypertension<br/>Secondary hypertension.

::Summary## "A fresh, new student-friendly physical therapy board review text National Physical Therapy Exam Review provides students with an outstanding review of entry level physical therapy concepts and principles. Following the human movement system and component elements such as anatomic structure and physiological function , the text is enhanced by innovative pedagogy and 1,000 questions (in print and online) that simulate the Physical Therapy Blueprint Practice Exam. Throughout the book, there is an emphasis on clinical application necessary to ensure safe and effective patient care. Follows the APTA's new vision which optimizes movement to improve the human experience. 1,000 exam review questions (in print and online). Numerous figures and tables. Pedagogy includes key terms, skill keeper questions (which prompt students to review previous material), clinical, scenarios, and chapter-ending questions"-- Provided by publisher. "This manual is your guide to prepare you for the National Physical Therapy Examination (NPTE) and earning your licensure. This guide includes insight from professional Physical Therapists on each component of the exam encompassing a review of NPTE content to best prepare you for successful exam results. This exam covers a broad range of topics from special populations to the body's main organ systems and how they interact to non-system components outlining professional responsibilities and ethics"-- Provided by publisher.<br/>::Contents##<br/>Chapter 1: Cardiac, Vascular, and Pulmonary Systems<br/>Chapter 2: Musculoskeletal Physical Therapy<br/>Chapter 3: Neuromuscular Physical Therapy<br/>Chapter 4: Integumentary System<br/>Chapter 5: Metabolic and Endocrine Systems<br/>Chapter 6: Gastrointestinal System<br/>Chapter 7: Genitourinary System<br/>Chapter 8: Non-Systems<br/>Chapter 9: Special Topics: Geriatrics<br/>Chapter 10: Special Topics: Pediatrics.

::Contents##<br/>Vol. 1. Secondary school students<br/>v. 2. College students and young adults.

::Contents##<br/>Anti-gal in humans and its antigen the ?-gal epitope<br/>Why do we produce anti-gal<br/>Anti-gal comprises most of anti-blood group b antibodies<br/>Anti-gal interaction with Trypansoma, Leishmania, and Plasmodium parasites<br/>Anti-gal b cells are tolerized by a ?-gal epitopes in the absence of t cell help<br/>Anti-gal and other immune barriers in xenotransplantation<br/>Anti-gal IgE mediates allergies to red meat<br/>Anti-gal and autoimmunity<br/>Anti-gal-mediated amplification of viral vaccine efficacy<br/>Cancer immunotherapy by anti-gal-mediated in situ conversion of tumors into autologous vaccines<br/>Anti-gal as cancer cell destroying antibody and as antibiotics targeted by ?-gal bifunctional molecules<br/>Acceleration of wound and burn healing by anti-gal/?-gal nanoparticles interaction<br/>Anti-gal and anti-non gal antibodies in regeneration of extracellular matrix bio-implants<br/>Post infarction regeneration of ischemic myocardium by intramyocardial injection of ?-gal nanoparticles<br/>Regeneration of injured spinal cord and peripheral nerves by ?-gal nanoparticles<br/>Inhalation of ?-gal/sialic acid liposomes for decreasing influenza virus infection.

::Summary## Bioactive compounds produced by natural sources, such as plants, microbes, endophytic fungi, etc., can potentially be applied in various fields, including agriculture, biotechnology and biomedicine. Several bioactive compounds have proved to be invaluable in mediating plant-microbe interactions, and promoting plant growth and development. Due to their numerous health-promoting properties, these compounds have been widely used as a source of medication since ancient times. However, there is an unprecedented need to meet the growing demand for natural bioactive compounds in the flavor and fragrance, food, and pharmaceutical industries. Moreover, discovering new lead molecules from natural sources is essential to overcoming the rising number of new diseases. In this regard, natural bioactive compounds hold tremendous potential for new drug discovery. Therefore, this field of research has become a vital area for researchers interested in understanding the chemistry, biosynthetic mechanisms, and pharmacological activities of these bioactive metabolites. This book describes the basics of bioactive plant compounds, their chemical properties, and their pharmacological biotechnological properties with regard to various human diseases and applications in the drug, cosmetics and herbal industries. It offers a valuable asset for all students, educators, researchers, and healthcare experts involved in agronomy, ecology, crop science, molecular biology, stress physiology, and natural products.<br/>::Contents##<br/>Chapter 1. Production and Application of Novel of Bio-active Compounds by Endophytic Microbes<br/>Chapter 2. Endophytes<br/>The Unmapped Repository For Natural Products<br/>Chapter 3. Microbial Hosts as a Promising Platform for Polyphenols Production<br/>Chapter 4. Endolichenic fungi From Common Lichens as New Sources for Valuable Bio-active Compounds<br/>Chapter 5. Strategic Approaches for the Purification of Glycosides from Natural Sources<br/>Chapter 6. Natural Products-Based Pancreatic Lipase Inhibitors for Obesity Treatment<br/>Chapter 7. Natural compounds extracted from medicinal plants and their applications<br/>Chapter 8. Seed Oils as a Source of Natural Bioactive Compounds<br/>Chapter 9. Essential Oils Extracted from Medicinal Plants and their Applications<br/>Chapter 10. Cellulose-based hydrogels: Present and Future<br/>Chapter 11. Influence of Elicitors and Eustressors on the Production of Plant Secondary Metabolites<br/>Chapter 12. KRAS as potential target in colorectal cancer therapy<br/>Chapter 13. Recent insights on the anticancer properties of flavonoids: Prospective candidates for cancer chemoprevention and therapy<br/>Chapter 14. Natural Compounds Extracted from Moringa oleifera and their Agricultural Applications<br/>Chapter 15. Natural compound from genus Brassica and their therapeutical activities<br/>Chapter 16. Antibacterial and Antifungal Agents of Higher Plants<br/>Chapter 17. Bio-active Compounds Isolated from Neem tree and their Applications<br/>Chapter 18. Role of Plant Secondary Metabolites as Antidiabetic Agents<br/>Chapter 19. Plant metabolites and Pharmacological activities of Leptadenia pyrotechnica (Forssk.) Decne<br/>Chapter 20. Functioning of Organosulfur Compounds from Garlic (Allium sativum Linn) in targeting risk factors mediated Atherosclerosis: A Crosstalk between Alternative and Modern Medicine<br/>Chapter 21. Biological activities and nutritional value of Physalis peruviana L<br/>Chapter 22. Yield, Chemical Composition and Biological Evaluation of the Essential Oil of Baccharis Milleflora in the Atlantic Rain Forest of the Paraná State in Brazil.

::Summary## Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.<br/>::Contents##<br/>Chapter 1. Secondary Metabolites from Rosemary (Rosmarinus officinalis L.): Structure, Biochemistry and Therapeutic Implications against Neurodegenerative Diseases<br/>Chapter 2. The role of plant metabolites in drug discovery: Current challenges and future perspectives<br/>Chapter 3. Current insights on the role of terpenoids as anticancer agents: a perspective on cancer prevention and treatment<br/>Chapter 4. Myristica fragrans Houtt.: Botanical, Pharmacological and Toxicological Aspects<br/>Chapter 5. Coscinium fenestratum: A Review on Phytochemicals and Pharmacological Properties<br/>Chapter 6. Computationally Designed Recombinant-DNA-Based Compounds Production Driven in Plants during Secondary Metabolism and Their Implication in Anti-Malaria Therapies<br/>Chapter 7. Curcumin-Loaded Nanoparticles and Their Potential as Anticancer Agents in Breast Cancer<br/>Chapter 8. Techniques for Extraction, Isolation and Standardization of Bioactive Compounds from Medicinal Plants<br/>Chapter 9. Phytotherapeutics: The Substitutes for Glioblastoma multiforme<br/>Chapter 10. Cosmetic Potential of Natural Products: Industrial Applications<br/>Chapter 11. Natural Compounds Extracted from Medicinal Plants and Their Applications in the Treatment of Diabetes and Hypertension<br/>Chapter 12. Plant Metabolites as New Leads to Drug Discovery<br/>Chapter 13. Natural Compounds Extracted from Medicinal Plants and their Applications in Cardiovascular and Kidney Diseases<br/>Chapter 14. Therapeutic Potential of Plant Polyphenolics and Their Mechanistic Action against Various Diseases<br/>Chapter 15. Phytochemical Aspects of Medicinal Plants of North-East India to Improve the Gynecological Disorders: An Update<br/>Chapter 16. Bio-active compounds from Unani medicinal plants and their application in Urolithiasis<br/>Chapter 17. Therapeutic Potential of Rhizomatous Plants used in Unani Medicare System<br/>Chapter 18. Extraction Techniques for Plant based Bioactive Compounds.

::Summary## Natural bioactive compounds have become an integral part of plant-microbe interactions geared toward adaptation to environmental changes. They regulate symbiosis, induce seed germination, and manifest allelopathic effects, i.e., they inhibit the growth of competing plant species in their vicinity. In addition, the use of natural bioactive compounds and their products is considered to be suitable and safe in e.g. alternative medicine. Thus, there is an unprecedented need to meet the increasing demand for plant secondary metabolites in the flavor and fragrance, food, and pharmaceutical industries. However, it is difficult to obtain a constant quantity of compounds from the cultivated plants, as their yield fluctuates due to several factors including genotypic variations, the geography, edaphic conditions, harvesting and processing methods. Yet familiarity with these substances and the exploration of various approaches could open new avenues in their production. This book describes the basis of bioactive plant compounds, their mechanisms and molecular actions with regard to various human diseases, and their applications in the drug, cosmetic and herbal industries. Accordingly, it offers a valuable resource for students, educators, researchers, and healthcare experts involved in agronomy, ecology, crop science, molecular biology, stress physiology, and natural products.<br/>::Contents##<br/>Chapter 1. Bioactive Peptides: Role in Plant Growth and Defense<br/>Chapter 2. Linking Omics Approaches to Medicinal Plants and Human Health<br/>Chapter 3. Application of Biotechnology in Producing Plant Bio-active Compounds<br/>Chapter 4. Transgenic plant cell cultures: A promising approach for secondary metabolites production<br/>Chapter 5. An Insight into Biotechnological Approaches Used for Improvement and Secondary Metabolites for Medicinal Aquatic Plant Water hyssop (Bacopa monnieri L.)<br/>Chapter 6. Prospects for the Use of Plant cell culture as alternatives to produce secondary metabolites<br/>Chapter 7. Biotechnological exercises in the production of secondary metabolites and its significance in health care practices<br/>Chapter 8. Salient biotechnological interventions in saffron (Crocus sativus L.), a major source of bioactive apocarotenoids<br/>Chapter 9. Recent advances in extraction, characterization and potential use of Citral<br/>Chapter 10. Hairy root cultures as an alternative source for the production of high-value secondary metabolites<br/>Chapter 11. Plant Cell Culture as Alternatives to Produce Secondary Metabolites<br/>Chapter 12. Metabolic Engineering Strategies for Enhancing the Production of Bioactive Compounds from Medicinal Plants<br/>Chapter 13. Enhancement of Rosmarinic Acid Content by Biotechnological Approaches and Metabolic Engineering.

::Summary## This book discusses various aspects of bioactive natural products employed in the agrochemical and agriculture sectors. It covers the use of plants, microorganisms, and microbial metabolites as eco-friendly, cost-effective, and sustainable alternatives to chemicals in the field of agriculture. Written by active researchers and academics, the book highlights state-of-art products in the field, as well as the gaps, challenges, and obstacles associated with the use of plants, microbes and their products. Given its scope, it is a valuable resource for the scientific community and professionals in enterprises wanting insights into the latest developments and advances in the context of biological products, including their applications, traditional uses, modern practices, and strategies to harness their full potential.<br/>::Contents##<br/>Intro<br/>Preface<br/>Contents<br/>Editors and Contributors<br/>About the Editors<br/>Contributors<br/>1: Natural Metabolites: An Eco-friendly Approach to Manage Plant Diseases and for Better Agriculture Farming<br/>1.1 Introduction<br/>1.2 Role of Natural Plant Products in Disease Management<br/>1.2.1 Coumarins<br/>1.2.2 Tannins or Gallotannin<br/>1.2.3 Alkaloids<br/>1.2.4 Terpenoids<br/>1.3 Plant Growth-Promoting Rhizobacteria (PGPR)<br/>1.4 Fungi as Biocontrol Agents<br/>1.5 Role of Mycorrhizae in Disease Management<br/>1.6 Management of Plant Diseases Caused by Plant Parasitic Nematodes 1.6.1 Paecilomyces lilacinus<br/>1.6.2 Trichoderma spp.<br/>1.6.3 Pochonia chlamydosporia<br/>1.6.4 Mycorrhizal Fungi<br/>1.6.5 Pasteuria penetrans<br/>1.6.6 Pseudomonas fluorescens<br/>1.6.7 Endophytic Bacteria<br/>1.6.8 Entomopathogenic Nematodes<br/>1.7 Future Prospects<br/>1.8 Conclusion<br/>References<br/>2: Plant Disease Management by Bioactive Natural Products<br/>2.1 Introduction<br/>2.2 Types of Bioactive Natural Products<br/>2.2.1 Microbial-Derived Natural Products<br/>2.2.2 Plant-Derived Natural Products<br/>2.2.3 Algal-Derived Natural Products<br/>2.2.4 Marine-Derived Natural Products 2.3 Conclusion and Future Prospects<br/>References<br/>3: Biological Control Agents: Diversity, Ecological Significances, and Biotechnological Applications<br/>3.1 Introduction<br/>3.2 Types of Interactions Contributing to Biological Control<br/>3.3 Types of Biological Control Agents (BCA)<br/>3.4 Mechanisms Involved for Biological Control<br/>3.5 Ecological Significances of Biological Control Agents<br/>3.6 Recent Advances and Genetic Engineering in the Biological Control Applications<br/>3.6.1 Genetic Modification for Developing Resistance Against Fungicides 3.6.2 Genetic Modification for Developing Hypovirulence<br/>3.6.3 Enhancement in Bacteriocins Synthesis<br/>3.6.4 Enhancement in Siderophore Synthesis<br/>3.6.5 Enhancement in Antibiotic Synthesis<br/>3.6.6 Enhancement in Lytic Enzyme Synthesis<br/>3.6.7 Enhanced Root Colonization Ability<br/>3.7 Conclusion and Future Prospects<br/>References<br/>4: Role of the Potent Microbial Based Bioagents and Their Emerging Strategies for the Ecofriendly Management of Agricultural Phytopathogens<br/>4.1 Introduction<br/>4.2 Merits and Demerits of Biological Control Agents (BCA) 4.3 Mechanisms Adopted by Biological Control Agents<br/>4.3.1 Microbial Antagonisms<br/>4.3.2 Parasitism<br/>4.3.3 Competition<br/>4.3.4 Production of Antimicrobial Compounds<br/>4.3.4.1 Antibiotics<br/>4.3.4.2 Iron-Chelating Siderophores<br/>4.3.4.3 Biocidal Volatiles<br/>4.3.4.4 Lytic Enzymes (Chitinases and Glucanases)<br/>4.3.4.5 Detoxification of Virulence Factors<br/>4.4 Priming and Induced Systemic Resistance<br/>4.5 Emerging Biocontrol Strategies<br/>4.5.1 Usage of Plant Exudates to Attract Beneficial Biocontrol Microbes

::Summary## This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed 'amyloid'. Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer's disease-related dementia and Parkinson's disease, as well as other less prevalent conditions like Huntington's disease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents. This book collectively presents a considerable body of experimental and epidemiological evidence from peer-reviewed scientific publications that support a role for natural compounds and herbal extracts in the chemoprevention and therapy of amyloidogenic disorders. Each contribution is written by scientific experts in the relevant field; chapters are devoted to Mediterranean diet and olive oil phenols, traditional Chinese medicine, herbal extracts, polyphenols (with a particular emphasis on epigallocatechin-3-gallate) and bi-flavonoids, amongst others. The topic of this book is relevant to a wide audience, from academia and university students in the biological and chemical sciences, to physicians and allied health professionals, as well as people working in the nutraceutical industry.<br/>::Contents##<br/>Olive Oil Phenols as Promising Multi-targeting Agents against Alzheimer's disease<br/>Alzheimer's disease, Drosophila melanogaster and Polyphenols<br/>Biflavonoids as Potential Small Molecule Therapeutics for Alzheimer's disease<br/>Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis.- Brain Food for Alzheimer-free Ageing: Focus on Herbal Medicines<br/>Tea Polyphenols in Parkinson's disease<br/>The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Suggests a Common Mechanism.

::Summary## This practical book focuses on the most recent advances in natural cycle and minimal stimulation in vitro fertilization (IVF). The volume presents the steps that need to be followed to successfully perform these techniques and covers all aspects and competences involved. The book provides information on physiology of folliculogenesis, ovulation, oocytes and luteal phase and based on this information on clinical practice of stimulation, ovulation induction and inhibition, follicle aspiration and luteal phase support in natural cycle and minimal stimulation IVF. In addition costs, risks, success rates and several treatment protocols are provided. An overview of large European, Japanese and American programs and the discussion of clinical cases will complete the coverage of the topic. This practical and easy-to-use guide is a valuable resource for all clinicians performing any kind of IVF techniques.<br/>::Contents##<br/>Basics<br/>Physiology<br/>Technical Aspects<br/>Costs, Risks, Success Rates<br/>Miscellaneous<br/>Worldwide Programs<br/>Case Discussions.

::Summary## This book aims to address the importance of natural enemies and functional diversity for biological control in Neotropical agroecosystems. Several aspects related to the conservation of natural enemies, such as vegetation design and climate change, are discussed in Part 1 and the bioecology of several insects groups used in biological control in Latin America is presented in Part 2. Part 3 is devoted to mass production of natural enemies while Part 4 describes how these insects have been used to control of pests in major crops, forests, pasture, weeds and plant diseases. Lastly, Part 5 reports Latin-American experiences of integration of biological in pest management programs.<br/>::Contents##<br/>Part 1. Conservation of natural enemies and functional biodiversity in Neotropical agroecosystems<br/>1. Vegetational design to enhance biological control of insect pests in agroecosystems<br/>2. Interactions of natural enemies with non-cultivated plants<br/>3. Quality of agroecosystems as habitats to natural enemies and biological control agents<br/>4. Plants as food for adult natural enemies<br/>5. Dispersion and increase of natural enemies in agroecosystems<br/>6. Climate change and biological control of pests in agriculture<br/>Part 2. Bioecology of natural enemies used in biological control in the Neotropical region<br/>7. Predator insects<br/>8. Predator mites<br/>9. Parasitoid insects<br/>10. Entomopathogenic nematodes<br/>11. Entomopathogenic fungi<br/>12. Entomopathogenic virus<br/>13. Bacillus thuringiensis<br/>14. Interactions of entomopathogenic fungus with entomophagous insects in agroecosystems<br/>Part 3. Mass production of biocontrol agents in Latin America: rearing techniques and releasing strategies<br/>15. Predators insects<br/>16. Predatory mites for the biological control of phytophagous mites<br/>17. Parasitoid insects<br/>18. Entomopathogenic nematodes<br/>19. Entomopathogenic fungi<br/>20. Entomopathogenic virus<br/>21. Bacillus thuringiensis<br/>Part 4. Biological control in major crops, forests, pasture, weeds and plant diseases in the Neotropical region<br/>22. Bean<br/>23. Coffee<br/>24. Cotton<br/>25. Forests<br/>26. Fruit crops<br/>27. Maize<br/>28. Oleraceous<br/>29. Ornamental plants<br/>30. Pasture<br/>31. Rice<br/>32. Soybean<br/>33. Sugarcane<br/>34. Microbial control of sugarcane pests<br/>35. Weeds<br/>36. Plant diseases<br/>37. Physiological and ecological selectivity of pesticides for natural enemies of insects<br/>38. Use of natural chemical products for pest control<br/>39. Effects of transgenic plants over natural enemies<br/>40. Use of silicon as resistance factor for plants against insect pests. Use of semiochemical-based strategies to enhance biological control<br/>41. Use of semiochemical-based strategies to enhance biological control<br/>42. Aphid-tending ants and their effects on natural enemies used in the biological control<br/>Index.

::Contents##<br/>Transcriptional control of NK cells<br/>Development, homeostasis, and heterogeneity of NK cells<br/>Diversification and functional specialization of human NK cell subsets<br/>Dynamic regulation of NK cell responsiveness<br/>NK cells and cancer immunoediting<br/>Sweet is the memory of past troubles: NK cells remember<br/>Lessons from NK cell definiencies in the mouse<br/>Probing human NK cell biology using human immune system (HIS) mice<br/>Haploidentical haematopoietic stem cell transplantation: role of NK cells and effect of cytomegalovirus infections<br/>The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer<br/>Index.

::Summary## "The ONLY evidence-based resource covering natural childbirth practices offering a logical middle-of-road approach to the natural birth movement. Natural Labor and Birth: An Evidence-Based Guide to the Natural Birth Plan is written to provide a reliable source of information for healthcare professionals caring for patients seeking a natural birth. Up until now, doctors and nurses who would like to work with women seeking a natural birth have been frustrated by the lack of easily accessible, trustworthy resources on this topic, and most have not been trained on how to utilize methods outside of the traditional framework. Evidence-based natural childbirth is not discussed in any unified fashion in any of the existing obstetrical texts. Natural Labor and Birth: An Evidence-Based Guide to the Natural Birth Plan seeks to end the friction between natural and traditional obstetrics care. It is unique in that it does not attempt to make a case for natural childbirth, it only seeks to demonstrate how natural birth can exist within the framework of typical antepartum care and hospital deliveries and respond to patient preferences. It teaches the skills necessary to assist a woman through an unmedicated childbirth that are not taught in most obstetrical residencies and nursing programs and provides a compilation of the medical evidence supporting alternative practices."-- Provided by publisher "The only evidence-based resource covering natural birth practices that will serve as a go-to resource on labor and delivery units for obstetricians, midwives, labor and delivery nurses, and doulas."-- Provided by publisher

::Summary## This book reviews the latest research on bioproducts from various economically important insects, such as silkworms, honey bees, lac and drosophila, and termites, and discusses their general, biomedical and industrial applications in detail. It includes chapters focusing on insects as a food source, probiotics, silk-based biomaterials, insect pheromones, insects as biomedicine source, pupa oil chemistry, non-protein compounds from Lepidopteran insects, insect chitin and chitosan, polyphenols and flavonoids. Model insects like Bombyx mori or bees were domesticated in Asian countries thousands of years ago. Over time, natural products from these animals became industrialized and today they attracting increasing attention thanks to their sustainability and their manifold applications in agriculture and biomedicine. The book is intended for entomologists, material scientists, natural product researchers and biotechnologists. .<br/>::Contents##<br/>1. Polyphenols and flavonoids from honey: Biological applications<br/>2. Chemistry and application of lac and its by-products<br/>3. Silk: an amazing biomaterial for future medication<br/>4. Insect Chitin and Chitosan: Structure, Properties, Production and Implementation Prospective<br/>5. Recent advances in the arthropod natural product chemistry<br/>6. Silkworm: A Unique Creature for Natural Products<br/>7. Present and future prospects on nutritious feeding using insects<br/>8. Insect Pheromones and its applications in management of pest population<br/>9. Non-Protein chemical compounds from Lepidopteran insect cocoons. .

::Summary## This introduces the theoretical and practical guide of NOSES. The book introduced 10 different techniques of NOSES for colorectal neoplasms based on extensive high-quality surgical images. The first part mainly describes the development process of NOSES and the current achievements of these techniques which will provide readers a general understanding of NOSES. The second part elaborates on ten different surgical procedures specific to position of tumor location of NOSES in detail. All key technical points and operational skills regarding to NOSES are displayed by both high-quality images. The indications and contraindications are also strictly determined in this book. In addition to the elaboration of NOSES, each chapter of this book also conduct a detailed and comprehensive analysis the hot spots, technical difficulties and key issues with regard to laparoscopic surgery for colorectal cancer. This book is suitable for the colorectal cancer surgeons and doctors of general surgery.

::Summary## This book introduces readers to nine techniques for natural orifice specimen extraction surgery (NOSES) in gastric cancer and fifteen different techniques for NOSES in colorectal cancer, respectively, based on extensive high-quality surgical images. The first part mainly describes the development process of NOSES and preoperative preparation,offering readers a general understanding of NOSES. In turn, the second and third parts elaborate on the surgical procedures for gastrointestinal cancer. All key technical points and operational skills regarding NOSES are covered, and the indications and contraindications are clearly defined. In addition, the book provides a detailed and comprehensive analysis of the hot spots, technical difficulties and key issues with regard to laparoscopic surgery for gastrointestinal cancer. Accordingly, it offers an essential guide for gastrointestinal cancer surgeons and general surgeons.

::Contents##<br/>Part 1. Natural Product Drugs and Cancer Therapeutics<br/>The Impact of Natural Products Upon Cancer Chemotherapy / A. Ganesan<br/>Identification and Development of Vascular Disrupting Agents: Natural Products That Interfere with Tumor Growth / Andrea T. Hooper, Frank Loganzo, Chad May and Hans-Peter Gerber<br/>Discodermolide: Past, Present, and Future / Ross E. Longley<br/>HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents / Lilibeth A. Salvador and Hendrik Luesch<br/>Natural Product Cytotoxins as Payloads for Antibody Drug Conjugates / Frank E. Koehn<br/>Part 2. Advances in Natural Product Cancer Drug Discovery<br/>Natural Product Scaffolds in Cancer Therapy / Christian P. Mang and Lars Ole Haustedt<br/>The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery / Claudia Eva-Maria Unsin, Scott R. Rajski and Ben Shen<br/>Accessing Anti-cancer Natural Products by Plant Cell Culture / Lisa M. Leone and Susan C. Roberts<br/>Natural Products as Tools for Discovering New Cancer Targets / John A. Beutler.

::Summary## Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers.

::Summary## Natural products have a long history of use as folk medicines in several systems of traditional medicine. Extensive evidence from modern pharmacological studies has confirmed traditional applications, and unveiled the vast potential of naturally occurring compounds, particularly plant-derived phytochemicals, in the management of chronic human diseases. The past decade has witnessed a surge of findings from randomized controlled trials testifying the safety and efficacy of natural products as adjuncts or alternatives to standard-of-care medications for several illnesses. Biomolecular studies have unveiled hundreds of cellular and molecular targets for phytochemicals including key transcription factors, receptors, enzymes, hormones, neurotransmitters, cytokines, lipids, and non-coding RNAs. Extensive research on the preventative and therapeutic effects of natural products necessitates regular updating of the literature as to the developing potential roles of these compounds in different human diseases. This new book provides an overview of the current pharmacological and clinical features of natural products, and the role of phytopharmaceutical compounds in health and diseases. Chapters cover a wide scope, from cancers, to chronic and age-related disorders, and are written by leading international subject experts. Collectively, chapters will provide useful insights on the regulatory effects of phytochemicals and nutraceuticals on pathogenic molecular signatures associated with pathologies, disease biomarkers, and aging-related pathways.

::Summary## This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research. .<br/>::Contents##<br/>1. Chemoprevention of Cancer: Past, Present, and Future<br/>2. Resveratrol for Cancer Prevention: Current Gaps and Opportunities<br/>3. Pterostilbene as a Potent Chemopreventive Agent in Cancer<br/>4. Pharmacokinetics and Bioavailability Enhancement of Natural Products<br/>5. Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention<br/>6. Anti-cancer Effects of Silibinin: The Current Status in Cancer Chemoprevention<br/>7. Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management<br/>8. Cancer Prevention by Tea Polyphenols<br/>9. The Chemopreventive Power of Isothiocyanates<br/>10. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control<br/>11. Anthocyanins and Cancer Prevention 12. Grape Chemopreventive Agents Against Angiogenesis and Metastasis<br/>13. Punica granatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment<br/>14. Cancer Chemopreventive Potential of Epidermal Growth Factor Receptor Inhibitors from Natural Products<br/>15. Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-Dependent Kinases<br/>16. Pro-apoptotic Properties of Chemopreventive Agents<br/>17. The Use of Anti-Inflammatory Agents for Cancer Chemoprevention<br/>18. Combination Cancer Chemoprevention by Targeting the Epigenome<br/>19. Perspective: A Positive Cocktail Effect of the Bioactive Components in the Diet.

::Contents##<br/>Marine algae: A source of biomass for biotechnological applications<br/>Structure and function of macroalgal natural products<br/>Spectrophotometric assays of major compounds extracted from algae<br/>Extraction and enrichment of protein from red and green macroalgae<br/>Extraction and purification of r-phycoerythrin from marine red algae<br/>Extraction and analysis of mycosporine-like amino acids in marine algae<br/>Extraction and purification of phlorotannins from brown algae<br/>Enzyme-enhanced extraction of antioxidant ingredients from algae<br/>Microwave-assisted extraction of fucoidan from marine algae<br/>Extraction and analysis of oxylipins from macroalgae illustrated on the example gracilaria vermiculophylla<br/>Lipids and fatty acids in algae: Extraction, fractionation into lipid classes, and analysis by gas chromatography coupled with flame ionization detector (GC-FD)<br/>HRMAS NMR analysis of algae and identification of molecules of interest via conventional 1d and 2d nmr: Sample preparation and optimization of experimental conditions<br/>Extraction, purification, and NMR analysis of terpenes from brown algae<br/>Extraction, isolation, and identification of sesquiterpenes from laurencia species<br/>The use of HPLC for the characterization of phytoplankton pigments<br/>Characterization of phlorotannins from brown algae by lc-hrms<br/>Analysis of betaines from marine algae using lc-ms-ms<br/>Analysis of marine biotoxins using lc-ms/ms<br/>Fucoidan analysis by tandem maldi-tof and esi mass spectrometry<br/>Determination of substitution patterns of galactans from green seaweeds of the bryopsidales<br/>Structural characterization of a hybrid carrageenan-like sulfated galactan from a marine red alga furcellaria lumbricalis<br/>Characterization of alginates by nuclear magnetic resonance (NMR) and vibrational spectroscopy (IR, NIR, RAMAN) in combination with chemometrics<br/>Imaging and identification of marine algal bioactive compounds by surface enhanced raman spectroscopy (SERS)<br/>In vitro protocols for measuring the antioxidant capacity of algal extracts<br/>Disk diffusion assay to assess the antimicrobial activity of marine algal extracts<br/>Screening of a marine algal extract for antifungal activities<br/>Protocol for assessing antifouling activities of macroalgal extracts.

::Summary## The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.<br/>::Contents##<br/>Natural products as enzyme inhibitors<br/>Molecular targets of clinically relevant natural products from filamentous marine cyanobacteria<br/>Natural angiotensin converting enzyme (ACE) inhibitors with antihypertensive properties<br/>Phospholipase A2 inhibitors of marine origin<br/>Beta-secretase (BACE1) inhibitors from natural products<br/>Hypoglycaemic effects of plants food constituents via inhibition of carbohydrate-hydrolysing enzymes: from chemistry to future applications<br/>Natural products targeting clinically relevant enzymes of eicosanoid biosynthesis implicated in inflammation and cancer<br/>Anti-HIV natural products<br/>Natural inhibitors of mitochondrial respiratory chain: therapeutic and toxicological implications<br/>Targeting enzymatic pathways with marine-derived clinical agents<br/>Anti-malarial drug discovery: new enzyme inhibitors<br/>Natural plant-derived acetylcholinesterase inhibitors: relevance for Alzheimer's disease.

::Summary## This book is an outcome of the keynote/lead papers presented by the experts from different disciplines in the Indian Ecological Society International Conference 2016 on "Natural Resource Management: Ecological Perspectives", organized at the Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, India. The book captures the essence of natural resource management from the intra and interdisciplinary perspectives of agricultural sciences (entomology, plant pathology, plant breeding and genetics, agronomy and soil sciences), social sciences (resource economics, agricultural extension education), medical sciences, and environmental sciences to stimulate discussion on the ecological perspectives of natural resource management. Wide-ranging topics on land and water resources, biodiversity, integrated farming system, role of microbes in agriculture, climate change and its impact on human health and crop pests, exploiting chemical ecology for pest management, human disease-causing pesticides, beneficial insects like lac insects, integrated pest management, resistance management in insect pests and Bt cotton, and diffusion and adoption of ecologically sustainable technologies at individual and organizational level are covered in the book. The book will serve the professionals, researchers, academia, government, industry and students.<br/>::Contents##<br/>1. Managing Wetland Ecosystems: A Polycentric Perspective<br/>Dinesh K. Marothia 2. Water Harvesting Techniques in Cold Deserts<br/>Chewang Norphel 3. Sustainability of Groundwater Use in Punjab Agriculture: Issues and Options<br/>Kamal Vatta 4. Sustainability of Himalayan Environment: Issues and Policies<br/>Masud. H. Wani 5. Crop Genetic Biodiversity with Special Reference to Oilseed Brassica and Wild allies: Conservation and their Utilisation<br/>Surinder K. Gupta 6. Integrated Farming System for Economic Upliftment of Marginal and Small Farmers<br/>Sohan S. Walia 7. Health Effects of Changing Environment<br/>Randeep Guleria 8. An Approach to Cancer Risk Assessment and Carcinogenic Potential for Three Classes of Agricultural Pesticide<br/>Chanda Siddoo Atwal 9. Integrated Pest Management and Climate Change: Need for Paradigm Shift<br/>C. Chattopadhyay 10. Role of Microbes for Plant and Soil Health Improvement<br/>Ambalal. N. Sabalpara 11. Exploiting Chemical Ecology for Developing Novel IPM Strategies<br/>Zeyaur R. Khan 12. Insect resistance to insecticides and Bt-cotton in India<br/>Sandhya Kranthi 13. Ecological Pest Management in 21st Century: An analysis of Challenges and future Strategies<br/>Dharam P. Abrol 14. Understanding the diversity in lac insects of Kerria spp. in India and the nature of insect-host plant interaction<br/>Kewal K. Sharma 15. Diffusion and Adoption: Factors Impacting Adoption of Sustainable Agricultural Practices<br/>Rajinder Peshin.

::Summary## The Systems Ecology Paradigm (SEP) incorporates humans as integral parts of ecosystems and emphasizes issues that have significant societal relevance such as grazing land, forestland, and agricultural ecosystem management, biodiversity and global change impacts. Accomplishing this societally relevant research requires cutting-edge basic and applied research. This book focuses on environmental and natural resource challenges confronting local to global societies for which the SEP methodology must be utilized for resolution. Key elements of SEP are a holistic perspective of ecological/social systems, systems thinking, and the ecosystem approach applied to real world, complex environmental and natural resource problems. The SEP and ecosystem approaches force scientific emphasis to be placed on collaborations with social scientists and behavioral, learning, and marketing professionals. The SEP has given environmental scientists, decision makers, citizen stakeholders, and land and water managers a powerful set of tools to analyse, integrate knowledge, and propose adoption of solutions to important local to global problems.

::Summary## This book contests the general view that natural selection constitutes the explanatory core of evolutionary biology. It invites the reader to consider an alternative view which favors a more complete and multidimensional interpretation. It is common to present the 1930-1960 period as characterized by the rise of the Modern Synthesis, an event structured around two main explanatory commitments: (1) Gradual evolution is explained by small genetic changes (variations) oriented by natural selection, a process leading to adaptation; (2) Evolutionary trends and speciational events are macroevolutionary phenomena that can be accounted for solely in terms of the extension of processes and mechanisms occurring at the previous microevolutionary level.^On this view, natural selection holds a central explanatory role in evolutionary theory - one that presumably reaches back to Charles Darwin's Origin of Species - a view also accompanied by the belief that the field of evolutionary biology is organized around a profound divide: theories relying on strong selective factors and those appealing only to weak ones. If one reads the new analyses presented in this volume by biologists, historians and philosophers, this divide seems to be collapsing at a rapid pace, opening an era dedicated to the search for a new paradigm for the development of evolutionary biology. Contrary to popular belief, scholars' position on natural selection is not in itself a significant discriminatory factor between most evolutionists.^In fact, the intellectual space is quite limited, if not non-existent, between, on the one hand, "Darwinists", who play down the central role of natural selection in evolutionary explanations, and, on the other hand, "non-Darwinists", who use it in a list of other evolutionary mechanisms. The "mechanism-centered" approach to evolutionary biology is too incomplete to fully make sense of its development. In this book the labels created under the traditional historiography - "Darwinian Revolution", "Eclipse of Darwinism", "Modern Synthesis", "Post-Synthetic Developments"--Are thus re-evaluated. This book will not only appeal to researchers working in evolutionary biology, but also to historians and philosophers."<br/>::Contents##<br/>Chapter 1: Introduction: In Search of a New Paradigm for the Development of Evolutionary Biology<br/>Part I: Crossing Perspectives about Evolution: Historians versus Biologists<br/>Chapter 2: Cathedrals, Corals and Mycelia: Three Analogies for the History of Evolutionary Biology<br/>Part II: Different Views of Charles Darwin<br/>Chapter 3: Guiding a Train of Discoveries: Charles Darwin, Charles Daubeny, and the Reception of Natural Selection, 1859-1865<br/>Chapter 4: Natural Selection as a Mere Auxiliary Hypothesis (sensu stricto I. Lakatos) in Charles Darwin's Origin of Species<br/>Chapter 5: Natural Selection in Ernst Haeckel's Legacy<br/>Part III: Rethinking a So-Called Intermediary Period<br/>Chapter 6: The Origins of Theoretical Developmental Genetics: Reinterpreting William Bateson's Role in the History of Evolutionary Thought<br/>Chapter 7: Recasting Natural Selection: Osborn and the Pluralistic View of Life<br/>Part IV: Other Evolutionary Syntheses<br/>^Chapter 8: Little Evolution, BIG Evolution: Rethinking the History of Darwinism, Population Genetics, and the "Synthesis"<br/>Chapter 9: When Panpsychism Met Monism: Why Did the Philosopher Theodor Ziehen (1862-1950) Become a Crucial Figure for the Evolutionary Biologist Bernhard Rensch?<br/>Chapter 10: Inertia, Trend, and Momentum Reconsidered: G.G. Simpson, an Orthogeneticist?<br/>Chapter 11: The Concept of Natural Selection in Theodosius Dobzhansky. Its Development and Interpretation<br/>Part V: New Lights on Recent Developments<br/>Chapter 12: What's Natural About Natural Selection?<br/>Chapter 13: Natural Selection, Morphoprocess and a Logical Field of Evolutionary Concepts<br/>Chapter 14: Natural Selection as Agent of Evolutionary Change: A View from Paleoanthropology<br/>Chapter 15: Darwinism Without Selection? A Lesson from Cultural Evolutionary Theory<br/>Part VI: Teaching Evolution<br/>^Chapter 16: Beyond Survival of the Fittest<br/>A Look at Students' Misconceptions about Natural Selection and Evolutionary Theory.

::Summary## This book discusses 120 types of natural, small-molecule drugs derived from plants. They are grouped into 7 parts according their clinical uses, such as drugs for cardiovascular diseases, for metabolic diseases, for neuropsychiatric diseases, for immune-mediated inflammatory diseases, anti-tumor drugs, and drugs for parasites and bacterial infection. Each chapter systematically summarizes one drug, including its physicochemical properties, sources, pharmacological effects and clinical applications. To help readers understand the drug better, the research and pharmacological activity for each drug is also described, which serves as a salutary lesson for future drug development. Written by frontline researchers, teachers and clinicians working in field of pharmacy and pharmacology it provides an overview of natural, small-molecule drugs derived from plants for researchers in the field.<br/>::Contents##<br/>Intro; Preface; Natural Medicines Are a Kind of Important Substances for Prevention and Treatment of Human Diseases; Natural Medicine Is the Foundation of Modern Pharmacy; Natural Small-Molecule Drugs Derived from Minerals; Natural Small-Molecule Drugs Derived from Microorganisms; Natural Small-Molecule Drugs Derived from Animals; Natural Small-Molecule Drugs Derived from Plants; The Research and Development of Natural Small-Molecule Drugs Embraces the Wisdom of Humans; Small-Molecule Drugs Derived from Plants Are the Representatives of Natural Medicines; Features and Instructions of the Book Part I: Natural Small-Molecule Drugs for the Prevention and Treatment of Cardiovascular Diseases; Overview; Ajmaline; Properties; Dosage Form and Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Anisodamine; Properties; Derivatives; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Caffeic Acid; Properties; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Cyclovirobuxine; Properties; Derivatives Dosage FormsIndications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Daidzein; Properties; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Daphnetin; Properties; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Dicoumarin; Properties; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Digoxin; Properties; Derivatives; Dosage Forms; Indications; Digitoxin PropertiesDosage Forms; Indications; Lanatoside C; Properties; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Dioscin; Properties; Dosage Forms and Indications; Literature; History of R Pharmacology; Discussion; References; Diosmin; Properties; Dosage Forms; Indications; Literature; History of R Pharmacology [4-6]; Clinical Application; Discussion; References; Divasidum; Properties; Dosage Forms and Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Ferulic Acid PropertiesDosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Hesperidin; Properties; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Ligustrazine; Properties; Dosage Forms; Indication; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Lovastatin; Properties; Derivatives; Dosage Forms; Indications; Literature; History of R Pharmacology; Clinical Application; Discussion; References; Metformin; Properties

::Summary## This book advances biomedical innovations to address the plethora of health problems afflicting the developing world. A panoply of cultural, economic, infrastructural, and other factors prevent many interventions currently popular in the developed world from being similarly effective in the developing world. This book discusses less-traditional approaches, such as naturally based biomaterials and therapeutics, an area that has traditionally been overlooked but has also demonstrated impressive potential for health applications in recent years. This book explores precisely the kinds of applications which can enable countries like India to access more effective, inexpensive treatments while also taking more ownership of their healthcare technologies and innovations.<br/>::Contents##<br/>Part I.<br/>1. Introduction to Global Health, Biomaterials, and Therapeutics<br/>2. Natural Resources with Potential for Health Applications<br/>(Bamboo, Banana, Coconut, Jackfruit, Jute, Rice, Silk, Soy, Tamarind<br/>Part II.<br/>3. Biomaterial and Therapeutic Applications<br/>Bamboo Applications<br/>Blood Purification<br/>Bone Repair or Replacement<br/>Neuroprotector<br/>Banana Applications<br/>Burn Dressing<br/>Inhibition of Viral Transmission<br/>Diabetes Treatment<br/>Bone Grafting<br/>Anti-Ulcerogenic<br/>Iron Absorption Promoter<br/>Coconut Applications<br/>Obesity and Diabetes Treatment<br/>Helminth Treatment<br/>Ulcer Treatment<br/>Intravenous Treatment<br/>Jackfruit Applications<br/>Protease Inhibitor<br/>Tablet Disintegrant-- Leukemia Treatment<br/>Jute Applications<br/>Wound Dressing<br/>Arsenic Protection<br/>Digesta Viscosity Elevation<br/>Rice Applications<br/>Protein Production<br/>Multifunctional Excipient<br/>Porous Scaffolds<br/>Sutures<br/>Silk Applications<br/>Corneal Grafts<br/>Optical Devices<br/>Conduits for Nerve Repair<br/>Bone Regeneration<br/>Drug Delivery<br/>Cartilage and Ligament Repair<br/>Multi-Functional Stents<br/>Soy Applications<br/>Bone Regeneration<br/>Inflammation Treatment-- Drug Delivery<br/>Tamarind Applications<br/>Drug Delivery<br/>Opthalmic Applications<br/>Anti-Malarial<br/>Anti-Obesity<br/>Antihelminthic<br/>Part III.<br/>4. Implications, Challenges, and Recommendations.

::Summary## The Nature and Use of Ecotoxicological Evidence: Natural Science, Statistics, Psychology, and Sociology examines how toxicologists and environmental professionals come to understand and make decisions about possible harm from pollutants. Drawing on concepts and techniques from the natural, social and mathematical sciences, the book emphasizes how pollutant-related evidence is gathered, assessed, communicated and applied in decision-making. Each chapter begins with a real-world example before exploring fundamental cognitive, social, statistical or natural science concepts to explain the opening example. Methods from other disciplines for recognizing, reducing or removing the influence of impediments in wise decision-making are highlighted in each chapter. Misreading evidence by the scientific community, and miscommunication to regulators and the public, remain major impediments to wise action in pollution issues. Which evidence comes to dominate the dialogue among scientists, regulators and decision makers depends on social and scientific dynamics. Yet psychological and sociological factors that influence the movement of evidence through scientific communities to regulators receive cursory discussion by professionals unfamiliar with the sociology literature. Toxicologists, environmental scientists, psychologists and professionals and students across the sciences will find the book useful for understanding how evidence is generated, assessed and communicated in their own fields.<br/>::Contents##<br/>Section 1. Introduction<br/>The emerging importance of pollution<br/>Section 2: How individuals gather and judge evidence<br/>Human reasoning: everyday heuristics and foibles<br/>Human reasoning: within scientific traditions and rules<br/>Pathological reasoning within sciences<br/>Individual scientist: reasoning by the numbers<br/>Section 3: How groups weigh and apply evidence<br/>Social processing of evidence: commonplace dynamics and foibles<br/>How innovations enter and move within groups<br/>Evidence in social networks<br/>Section 4: Conclusion<br/>Conclusion.

::Summary## This book, endorsed by the International Council of Nurses, explores a new conversation around scholarly talents for advanced candidate /nurse practitioners that comprise a variety of forms such as teaching, synthesis, discovery, engagement and application. It offers an expansive view of Boyer’s scholarship, with a call to action for advanced candidate /nurse practitioners to thoughtfully plan and map their personal goals and capabilities, that will mark them as professionals and future scholars needed in today’s challenging and changing professional workplace. Knowing how to apply the various forms of scholarship to problems of practice within one’s field of expertise and the implications of Boyer’s pillars of scholarship for advanced candidate / nurse practitioners are interweaved throughout this book. The volume discusses the science of career cartography, alongside legacy planning and career mapping. The toolkit illustrates a guide for advanced candidate /nurse practitioners to create their individual career legacy map and reflect on how they wish to contribute to the discipline of nursing, while working to improve the lives of others. This book serves as a catalyst for robust conversations among scholar practitioners on the very nature of clinical scholarship

::Summary## This book offers comprehensive coverage of naturopathic medicine. The principles and values of this profession are already clearly stated (i.e., Find and Treat the Cause; Treat the Whole Person, etc.), but few are the textbooks that directly compare it to conventional or allopathic medicine. To paraphrase the historian of medicine Harris Coulter in this approach the body reacts creatively to stressors and the Empirical school or natural medicine approach is more focused on supporting adaptive responses than suppressing symptoms. This is not an attempt to argue that all health issues can get better on their own or that conventional medical interventions arent capable of producing stellar outcomes, but there remains a concurrent need for a naturopathic approach that helps rebuild the body. This book presents an approach in medicine that works to support adaptive responses of the body, reduce maladaptive responses, address determining factors of health, and sometimes create temporary homeostasis with agents such as drugs (or certain natural medicines). In terms of the basis of disease states, the book teaches about how the lack of coordination in the bodys bioregulatory systems can lead to disease, as well as the impact of irreversible degeneration, genetic damage, chronic stress, etc. The book takes the reader to some of the more common and well described reasons for these states of dysfunction, how to assess a patient, and how various natural therapies impact root causes of disease, the long term consequences, and the various clinical manifestations. The book then takes a systems approach cardiovascular, pulmonary, etc. This is where most books on the subject start, but instead of breaking out a number of conditions and giving protocols of diet, supplements, herbs etc., the author examines how to restore stability and function to that system. Special topics are then covered, ranging from lifespan/primary care considerations to the role of research, the rise of advanced data analytics as decision assistance, to the environmental, cultural, and global determinants of health. Each chapter will additionally include tables that summarize key diagnosis or treatment points, arrayed in an order that reflects the model presented in the book. This is an ideal guide for students in naturopathic medicine, as well as physicians and medical professionals looking to learn more about this field aimed towards maximizing patient resilience.<br/>::Contents##<br/>The nature of health, homeostasis, adaptation, biological plasticity, repair<br/>Disease (Theory of)<br/>Where does a naturopathic approach apply?<br/>Causes of ill health<br/>Assessment of the patient<br/>Therapeutics<br/>States of ill health assessment and overall mitigation<br/>Systems Approach to Therapy<br/>Life-span considerations<br/>Naturopathic medicine in context<br/>The role of research and scientific inquiry in naturopathic medicine<br/>The role of informatics and artificial intelligence in naturopathic medicine<br/>Societal, global, environmental impact that naturopathic physicians can have<br/>Appendix A: Recommended resources for clinical/scientific information<br/>Appendix B: Professional associations and public interest groups related to whole health, complementary and integrative medicine, naturopathic medicine, etc.

::Summary## This book is the first comprehensive work summarizing the advances that have been made in the neurosurgical use of navigated transcranial magnetic stimulation (nTMS) over the past ten years. Having increasingly gained acceptance as a presurgical mapping modality in neurosurgery, today it is widely used for preoperative mapping of cortical motor and language function, risk stratification and improving the accuracy of subcortical fiber bundle visualization. This unique work will provide neurosurgeons and neuroscientists who are starting their nTMS program essential and detailed information on the technique and protocols, as well as the current clinical evidence on and limitations of the various applications of nTMS. At the same time, more experienced nTMS users looking for deeper insights into nTMS mapping and treatment in neurosurgery will find clearly structured, accessible information. The book was prepared by an international mix of authors, each of which was chosen for their status as a respected expert on the respective subtopic, as evinced by their landmark publications on nTMS.<br/>::Contents##<br/>Basic principles of nTMS<br/>nTMS motor mapping<br/>Basic principles and clinical use<br/>Fiber tracking<br/>Risk stratification<br/>nTMS language mapping<br/>Basic principles and clinical use<br/>Fiber tracking<br/>Risk stratification<br/>Other brain functions<br/>Therapeutic applications in neurosurgery<br/>Pain<br/>Paresis<br/>Special aspects on nTMS in children<br/>Outlook on the potential of nTMS<br/>Integration of functional data in the clinical workflow<br/>Methodological advantages and disadvantages of nTMS compared to MEG and fMRI.

::Summary## This book discusses the management of various aspects of the professional life of newly qualified urologists as well as more experienced urologists. It features clear, easy-to-read chapters covering various topics, including clinical and surgical patient care, administrative duties, and research despite the increasing constraints on time and resources in today's hectic practice environment. Navigating Organized Urology: A Practical Guide systematically presents a range of practical strategies for a successful transition from trainee to practising urologist, while also offering more experienced urologists a fresh perspective on efficient management and successful adaptation of their practices for the modern age. -- Provided by publisher.<br/>::Contents##<br/>Knowing Yourself<br/>Finding the Right Job<br/>The Role of the Educator<br/>The Urologist as an Effective Administrative Leader<br/>The Urologist as Researcher<br/>Academic Roles: Inventor<br/>Academic Research Collaboration<br/>Patient Satisfaction<br/>Managing the Operating Room: A Urologist's Guide to Enhancing Efficiency and Quality<br/>Enhancing and Promoting Your Office Urology Practice<br/>The Importance of Coding and Billing<br/>Time Management<br/>Media and Social Media<br/>Burnout, Happiness and Work-Life Harmony<br/>The Power of History and Leveraging Past Institutional Success<br/>Re-Evaluating yourself.

::Summary## This extensively revised second edition of the text discusses the management of various aspects of the professional life of newly qualified urologists as well as more experienced urologists. It features clear, easy-to-read chapters covering various topics, including clinical and surgical patient care, administrative duties, and research in today's hectic practice environment. New topics covered include how to manage an operating theater, telemedicine and how to manage crisis situations. Lessons acquired from the authors experiences of the COVID-19 Pandemic are also detailed. Navigating Organized Urology: A Practical Guide systematically presents a range of practical strategies for a successful transition from trainee to practicing urologist, while also offering more experienced urologists a fresh perspective on efficient management and successful adaptation of their practices for the modern age.

::Summary## "The past decade has seen major advances in image-guided spine surgery techniques, with robotically assisted approaches emerging in the last five years. While early adopters of this technology paved the way for more widespread use of navigated and robotic systems, barriers still exist. Navigation and Robotics in Spine Surgery by master spine surgeon Alexander Vaccaro and esteemed co-editors Jaykar Panchmatia, David Kaye, and Srinivas Prasad addresses existing issues such as the perception of increased upfront costs, intrusion on current workflow, and a lack of understanding about the potential ways these technologies can enhance the surgical experience and improve patient outcomes. Organized into six sections, the book starts with evidence-based fundamentals of navigated spine surgery and robotics including discussion of instrumentation and mechanics. Sections 2-5 serve as a surgical handbook for spine surgeons who wish to introduce these technologies into practice or augment their current repertoire with more complex techniques. Topics range from more routine procedures such as navigated and robotic minimally invasive TLIF to complex approaches like intraoperative ultrasound guided intradural spinal tumor resection. The final section looks at future directions and potential new applications for these technologies. Key Highlights An impressive group of international spine surgeons who pioneered navigation and robotic surgery techniques share invaluable tricks of the trade Discussion of fluoroscopy- and intraoperative CT-based platforms, applications for intraoperative sonography, and radiation exposure and minimization strategies Special topics include OR set-up and workflow, surmounting the learning curve, artificial intelligence, and lessons learned from other industries"-- Provided by publisher.

::Summary## The book introduces the using of navigation assisted robotic system in orthopedic surgery. The system is based on real-time 3D navigation. In the first part, it covers spine surgery, which includes pedicle screw fixation on cervical, thoracic, lumbar spine, dens screw fixation, Margerl screw fixation, PVP, PKP, and MED. The second part is about trauma surgery, which covers screw fixation in pelvis fracture and acetabulum fracture. This book is mainly written for spine surgeons, neurosurgeons, and traumatic orthopedic surgeons.<br/>::Contents##<br/>History and Development of Robotic Assisted Orthopedic Surgery<br/>Basic Principle of Robot-Assisted Orthopedic Surgery<br/>Use of Artificial Potential Field Theory to Determine the Spatial Position of a Navigation-Guided Orthopedic Surgical Robot<br/>Future Trends and Perspectives<br/>Magerl method of C1-C2 transarticular screw fixation<br/>Robot-Assisted posterior C1 and C2 Screw Fixation<br/>Robot-Assisted Odontoid Fracture Anterior Screw Fixation<br/>Robot-assisted C2 Pedicle Screw Placement for the Treatment of Hangman Fracture<br/>Robot Assisted Cervical Pedicle Screw Fixation<br/>Robot assisted thoracic pedicle screw fixation technique<br/>Robot-assisted Spine Surgery in Spinal Deformities<br/>Robot-assisted Lumbar Pedicle Screw Fixation<br/>Vertebroplasty in Osteoporotic Spine<br/>Robot-assisted Translaminar Lag Screw Fixation of Spondylolysis<br/>Robot assisted Percutaneous Transforaminal Endoscopy Discectomy<br/>Cortical Bone Trajectory for Lumbar Pedicle Screw Placement<br/>The Complications of Robot-assisted Spine surgery<br/>Robot-Assisted Free Vascularised Fibular Grafting for the Treatment of Osteonecrosis of the Femoral Head<br/>An Overview of Robotic Applications in Traumatic Orthopedics<br/>Research Study of Robotic-assisted Pelvic Fracture Reduction<br/>Application of Navigation Assisted Robot in Internal Fixation of Fracture.

::Summary## This book offers a comprehensive overview of the fundamentals of navigation surgery in the head and neck region. Navigation is particularly important in difficult and limited exposure areas, such as the orbit and deep spaces of the head and neck. With the aid of navigation systems, an expert can palpably and accurately measure the amount of bone removed during fracture reductions or resections of bony masses procedures. In addition to reducing surgery time for soft tissue lesions, navigation technique also allows for minimally invasive access to lesions without extensive dissection that is often required for traditional open approaches. Navigation can also be extremely helpful in locating and retrieving foreign bodies. Chapters cover navigation in a variety of different surgical specialties including, but not limited to, trauma surgery, implant surgery, and orthogenetic surgery. Chapters also discuss surgical pathology as well as guided surgeries. The book features detailed case presentations for each surgery sub-topic and discusses future advances in the field that are currently in development. Navigation in Oral & Maxillofacial Surgery is a must-have resource for clinicians, professionals, and practitioners in the fields of oral & maxillofacial surgery, otorhinolaryngology-head & neck surgery, trauma surgery, and plastic surgery, as well as researchers and postgraduate students in related fields.<br/>::Contents##<br/>Fundamentals of Navigation surgery<br/>Navigation in Orthgnatic surgery<br/>Navigation in Trauma surgery<br/>Navigation in surgical pathology<br/>Navigation in Implant surgery<br/>Navigation & guided surgery.

::Contents##<br/>Surviving the NCLEX<br/>Care of the Adult<br/>Care of the Psychiatric Client<br/>Maternal-Neonatal Care<br/>Care of the Child<br/>Issues in Nursing<br/>Appendices.

::Summary## This heavily revised book features a variety of cases detailing potential complications in cardiac surgery. Clinical scenarios associated with conundrums and unforeseen circumstances are presented, including minimally invasive and hybrid procedures as well as temporary mechanical circulatory support. Discussions emphasize critical details in preoperative assessment and intraoperative sensemaking, decision making and error recovery. Chapters are structured as unknowns, presenting findings as one would experience the events clinically and challenging the reader to develop their own rescue strategies. Relevant references for further reading are included, enabling the reader to further develop their knowledge base. Near Misses in Cardiac Surgery is a concise case-based resource featuring instructions on how to deal with potential complications associated with cardiac surgery. The work's multi-disciplinary authorship ensures it is a valuable resource for all medical professionals involved in the care of cardiac surgical patients.<br/>::Contents##<br/>Chapter 1. Aortic Cannulation (Jordan P. Bloom)<br/>Chapter 2. Return to the Operating Room (Myles E. Lee)<br/>Chapter 3. Cannulation for ECMO (John M. Trahanas)<br/>Chapter 4. Transcatheter Aortic Valve Replacement (TAVR) (Asishana Osho)<br/>Chapter 5. Accidental Arterial Decannulation (Antonia Kreso)<br/>Chapter 6. CABG after MI (Asishana Osho)<br/>Chapter 7. Air in the Circuit (Antonia Kreso)<br/>Chapter 8. EKG Changes after Mitral Repair (Antonia Kreso)<br/>Chapter 9. ECMO as a Bridge (Asishana Osho)<br/>Chapter 10. Complications of Transcatheter Aortic Valve Replacement (TAVR) (Asishana Osho)<br/>Chapter 11. Catastrophic Bleeding from Right Atrium (Andrew C. W. Baldwin)<br/>Chapter 12. Hypoxia on Bypass (Antonia Kreso)<br/>Chapter 13. Challenges in Myocardial Protection (Brittany Potz)<br/>Chapter 14. Empty Venous Reservoir (Myles E. Lee)<br/>Chapter 15. Arrest on Induction (Sameer Lakha)<br/>Chapter 16. xtracorporeal Cardiopulmonary Resuscitation (Jerome C. Cowley)<br/>Chapter 17. Postoperative Hypotension in the ICU (Myles E. Lee)<br/>Chapter 18. Hemodynamic instability after Pulmonary Thrombo-Endarterectomy (Asishana Osho)<br/>Chapter 19. Inadequate Venous Drainage (Antonia Kreso)<br/>Chapter 20. Trapped Mitral Leaflet (Antonia Kreso)<br/>Chapter 21. Even More Complications of TAVR (Asishana Osho)<br/>Chapter 22. Conduit for Redo CABG (Brittany Potz)<br/>Chapter 23. Intraoperative Coagulopathy (Monica Miller)<br/>Chapter 24. Hypoxia after Atrial Septal Defect (ASD) Closure (Jordan P. Bloom)<br/>Chapter 25. Intraoperative Pulmonary Hemorrhage (Lynze R. Franko)<br/>Chapter 26. Femoral Arterial Cannulation (Thoralf M. Sundt)<br/>Chapter 27. Hypoxia on ECMO (Jerome C. Crowley)<br/>Chapter 28. Laser Lead Extraction (Travis Hull)<br/>Chapter 29. Tube Thoracostomy for hemothorax (Lynze R. Franko)<br/>Chapter 30. Pulmonary Hypertension (Corey Spiro)<br/>Chapter 31. Malfunction of an Intra-aortic Balloon (Thoralf M. Sundt)<br/>Chapter 32. Symptomatic Aortic Stenosis (Thoralf M. Sundt)<br/>Chapter 33. Pulmonary Embolism (Thoralf M. Sundt)<br/>Chapter 34. Post-Operative Bleeding (Greg A. Leya)<br/>Chapter 35. Intraoperative Extracorporeal Cardiopulmonary Resuscitation (Travis Hull)<br/>Chapter 36. Mitral Annular Calcification (Antonia Kreso)<br/>Chapter 37. Options for a Patient with History of HITT (Jenna Cottral)<br/>Chapter 38. Ventricular Dysrhythmia after AVR (Andrew C. W. Baldwin)<br/>Chapter 39. Postoperative Hypoxemia (Rachel Steinhorn)<br/>Chapter 40. Orthotopic Heart Transplant (OHT) after LVAD (S. Alireza Rabi)<br/>Chapter 41. Postoperative Infection (Myles E. Lee)<br/>Chapter 42. Veno-venous ECMO (Travis Hull)<br/>Chapter 43. Reoperative Sternotomy (Brittany Potz)<br/>Chapter 44. Sternal Closure: Immediate or Delayed (Greg A. Leya)<br/>Chapter 45. Suction Event after LVAD Placement (S. Alireza Rabi)<br/>Chapter 46. Thrombosed Mechanical Valve (Antonia Kreso)<br/>Chapter 47. Valve-sparing Aortic Root Repair (Andrew A. C. Baldwin)<br/>Chapter 48. Acute Aortic Dissection (Rizwan Q. Attia)<br/>Chapter 49. Hypotension on Bypass (Checklist) (Myles E. Lee)<br/>Chapter 50. Debriding Candle Wax Calcification (Jordan Bloom).

::Summary## Authored by ""a superb clinician and award-winning teacher, ""* Near Misses in Pediatric Anesthesiology, Second Edition is a thorough updating and significant expansion of this popular case book in the newest anesthesiology subspecialty to be approved by the American Board of Medical Specialties. The book comprises 87 true-story clinical ""near misses, "" including 40 cases that are brand new. Recommendations, references, and discussion accompany each case. The cases provide an ideal basis for problem-centered learning and also model how to learn from experience and to maintain professionalism.

::Summary## "From racial hierarchies to authentic storytelling, the narrative of Mississippi is one of contrasts that parallel and amplify larger national trends in many ways. To study Mississippi, where RWJF held its fifth annual Sharing Knowledge conference in March 2020, is to learn how structural racism was built, venerated, and fiercely defended in the United States to maintain the status quo of non-White disenfranchisement. Yet the story of the state is also one of strength, rooted in a people who have worked collectively and in community to fight a system designed to punch back"-- Provided by publisher.

::Summary## "Neck dissection is a surgical procedure to remove cancerous lymph nodes, on patients diagnosed with cancer of the mouth, tongue, thyroid gland, or other areas of the throat or neck. There are three main types of neck dissection: Radical - all tissue on the side of the neck from the jawbone to the collarbone is removed. The muscle, nerve, salivary gland, and major blood vessel in this area are removed. Modified - all lymph nodes are removed. More neck tissue is spared. Selective - fewer lymph nodes have to be removed. The muscle, nerve, and blood vessel in the neck may also be saved. Neck Dissection will be an authoritative text edited by two distinguished surgeons, covering fundamentals of the various dissection types and which approach to use depending on patient clinical findings. The print text will be supplemented with surgical videos"-- Provided by publisher.

::Contents##<br/>Introduction to the necropsy<br/>Necropsy basics<br/>The necropsy procedure<br/>The integumentary system<br/>The musculoskeletal system<br/>The cardiovascular system<br/>The respiratory system<br/>The alimentary system<br/>The liver and pancreas<br/>The genitourinary system<br/>The nervous system<br/>The eye and ear<br/>The endocrine system<br/>The lymphoreticular system<br/>Necropsy of other small mammals<br/>Necropsy of fetuses and newborns<br/>Cytology<br/>Histopathology<br/>Infectious disease testing<br/>Toxicology testing<br/>Packaging and shipping samples.

::Summary## Cell death is an essential process in development, and a major contributor to a wide range of human diseases. Three major classifications of cell death, apoptosis, autophagic cell death and necrosis, have been described for years, and the existence of many more forms of cell death is now accepted. In, Necrosis: Methods and Protocols experts in the field provide a wide range of methods and techniques for the study of necrosis in vitro and in vivo. These include methods and techniques for the analysis of necrosis in mammalian cells, characterization of alternative forms of cell death: entosis and pyroptosis, and analysis of cell death in non-mammalian model sytems and mammalian tissues, including chapters on skin, brain, and heart. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. -- Publisher website.<br/>::Contents##<br/>Navigation to the graveyard-induction of various pathways of necrosis and their classification by flow cytometry / Christina Janko [and others]<br/>Time-lapse imaging of necrosis / Fredrik Wållberg, Tencho Tenev, and Pascal Meier<br/>Activity assays for receptor-interacting protein kinase 1 : a key regulator of necroptosis / Jenny L. Maki and Alexei Degterev<br/>Fluorescent biosensors for the detection of HMGB1 release / Isabelle Martins [and others]<br/>Methods for the study of entosis / Qiang Sun and Michael Overholtzer<br/>Analysis of pyroptosis in bacterial infection / Lia Danelishvili and Luiz E. Bermudez<br/>Analysis of cell death by electron microscopy / S. Burattini and E. Falcieri<br/>Histological analysis of neurodegeneration in the mouse brain / Hiroo Yamaguchi and Jie Shen<br/>Quantitation of acute necrosis after experimental myocardial infarction / Xin-Yi Yeap .. [et al.]<br/>Immunohistological tools to discriminate apoptotic and necrotic cell death in the skin / Marion C. Bonnet<br/>Identification and characterization of programmed cell death markers in bacterial models / Daniel J. Dwyer and Jonathan A. Winkler<br/>Quantification of genetically controlled cell death in budding yeast / Xinchen Teng and J. Marie Hardwick<br/>Necrosis in C. elegans / Matt Crook, Avni Upadhyay, and Wendy Hanna-Rose<br/>Monitoring the clearance of apoptotic and necrotic cells in the nematode Caenorhabditis elegans / Zao Li [and others]<br/>Modeling calcium-overload mediated necrosis in Drosophila / Kai Liu, Yuhong Li, and Lei Liu<br/>Use of necrotic markers in the Drosophila ovary / Allison K. Timmons [and others]<br/>Detection and measurement of necrosis in plants / Elena A. Minina [and others].

::Summary## This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers' understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.<br/>::Contents##<br/>Chapter 1: The INFECT-project: An international multidisciplinary project on necrotizing soft tissue infections<br/>Chapter 2: Necrotizing Soft Tissue Infections: case reports from the patients prospective<br/>Chapter 3: Necrotizing soft tissue infections: Case-reports, from the clinician's perspectives<br/>Chapter 4: Necrotizing soft tissue infections: clinical features and diagnostic aspects<br/>Chapter 5: Microbiological etiology of necrotizing soft tissue infections<br/>Chapter 6: Beta-hemolytic streptococci and necrotizing soft tissue infections<br/>Chapter 7: Treatment of necrotizing soft tissue infections: Antibiotics<br/>Chapter 8: Treatment of necrotizing soft tissue infections: IVIG<br/>Chapter 9: Pathogenic mechanisms of streptococcal necrotizing soft tissue infections<br/>Chapter 10: Systems genetics approaches in mouse models of Group A Streptococcal necrotizing soft tissue infections<br/>Chapter 11: Systems biology and biomarkers in necrotizing soft tissue infections<br/>Chapter 12: Systems and precision medicine in necrotizing soft tissue infections.

::Contents##<br/>Contents<br/>1. deel. Inleiding, organismale en algemeene physiologie<br/>2. deel. Bloed en lymphe, ademhaling en spijsvertering<br/>3. deel. Hart, bloedsomloop, voortplanting<br/>5. deel. Centraal Zenuwstelsel.

::Summary## This book describes the sequencing efforts for Neem (Azadirachta indica A. Juss), one of the most versatile tropical evergreen tree species. The neem tree is a source of various natural products, including the potent biopesticide azadirachtin and limonoids, which have a broad spectrum of activity against insect pests and microbial pathogens. To identify genes and pathways in neem, three neem genomes and several transcriptomes are studied using next-generation sequencing technologies. Neem has been extensively used in Ayurveda, Unani and homoeopathic medicine and is often referred to as the 'village pharmacy by natives due to its wealth of medicinal properties. Besides the description of the genome, this book discusses the neem microbiome and its role in the production of neem metabolites like salanin, nimbin and exopy-azadirachtin under in vitro conditions. It also highlights cell and tissue culture using various neem explants including the leaf, root, shoot, cambium, etc.<br/>::Contents##<br/>Economic/Academic importance<br/>Botanical descriptions and distribution<br/>Traditional practices and knowledge of neem<br/>Biochemistry, medicinal properties and molecular biology of neem bioactives<br/>Quantification of secondary metabolites of neem<br/>Utilization of neem and neem products in agriculture<br/>Requirement of whole-genome sequencing<br/>Strategies & tools for sequencing<br/>Genome Assembly<br/>Repetitive sequences<br/>Gene annotation<br/>Synteny with allied & model genomes<br/>Comparison of gene families<br/>Impact on neem tree improvement breeding<br/>Neem tissue culture<br/>Neem microbiome<br/>Future prospects.

::Summary## Neglected tropical diseases (NTDs) are a group of diseases frequently found in impoverished communities in tropical and sub-tropical countries. The risk for many of the NTDs is high in both deprived urban and rural areas of East Asia. Adapted to the endemic settings and characteristics of the diseases, a range of tools and strategies are currently being rolled out for the large-scale control of many NTDs. Both vector control measures and community sensitization programmes have for example been used to control dengue in urbanized settings. Challenges posed by yaws and lymphatic filariasis are being addressed by mass drug administration, while rabies requires the involvement of the veterinary public health sector for disease control. For leprosy, an elimination target has been defined; however, achieving this goal remains a considerable challenge. Food-borne trematodiases, on the other hand, are emerging and require a deeper understanding of its burden in East Asia and how these diseases can be tackled in a cost-effective manner. Finally, factors, such as an increase of non-communicable diseases due to changing lifestyles which accompany economic growth, the spreading HIV epidemic as well as climate change and the occurrence of natural disasters can potentially affect the epidemiology and control of NTDs. This volume discusses the mentioned topics in detail with contributions by experts in the respective research areas from different working environments.<br/>::Contents##<br/>1. Introduction<br/>2. Foodborne trematodiases in East Asia: epidemiology and burden<br/>3. Leprosy in East Asia<br/>4. Dengue, an expanding neglected tropical disease<br/>5. Yaws in South-East Asia: towards global eradication<br/>6. Rabies in East and Southeast Asia<br/>a mirror of the global situation<br/>7. Coinfection with helminths and HIV-1 in East Asia<br/>8. Links between the Epidemiology and Control of Non-Communicable Diseases and Neglected Tropical Diseases in Asia.

::Summary## This volume of the Neglected Tropical Diseases (NTD) series covers the most prevalent NTDs in North America. This book discusses in detail pathology, diagnostics and control approaches of selected NTDs in the sub-tropical regions of the United States of America. There are disproportionate numbers of children and adults living in poverty within the United States that are at risk of infections caused by helminths, protozoa, viruses and bacteria which commonly lead to chronic, debilitating and stigmatizing diseases. Each chapter focuses on one specific disease or series of related diseases, and provides in-depth insights into the topic.<br/>::Contents##<br/>Soil Transmitted Helminthiasis<br/>Toxocariasis<br/>Strongyloidiasis<br/>Taeniasis and Cysticercosis<br/>Toxoplasmosis<br/>Chagas Disease<br/>Leishmaniasis<br/>Trichomoniasis<br/>Chikungunya, Dengue, Zika, and Other Emerging Mosquito-Borne Viruses<br/>West Nile Virus<br/>Hansens Disease<br/>Murine Typhus.

::Summary## It has long been theorized that people living in poor areas have more health problems than their more advantaged peers. More recently, science has been testing this hypothesis, concentrating on the impact of the built environment on well-being and its contribution to health inequities.Neighbourhood Structure and Health Promotion offers sociology-based theory and evidence-based findings so readers may better understand the effects of place on health choices, behaviour, and outcomes. This international volume analyzes the complex relationships among neighbourhood conditions and characteristics,<br/>::Contents##<br/>Understanding Health as a Matter of Place<br/>Neighbourhood Context and Mortality: An Overview<br/>Area Effects on Behaviour and Lifestyle: The Spatiality of Injustice<br/>Sociological Perspectives on Neighbourhood Context and Health<br/>People and Place: The Interrelated Connections Between Interactions, Perceptions and Space<br/>Measuring and Monitoring Neighbourhood Structure<br/>Methods to Measure Neighbourhoods and Analyse Their Impact on Health: An Overview<br/>Access to Health-Promoting Facilities and Amenities<br/>GIS: A Spatial Turn in the Health Science?<br/>Using GPS to Measure the Interaction Between Individuals and Their Neighbourhood<br/>Mathematical Approaches to Analysing Area-Level Effects on Health<br/>Neighbourhood and Lifestyle<br/>Vitamin G (Green Spaces and Health): Potential Mechanisms, Policy Implications and Ideas for Further Research<br/>Socioeconomic Differences in Physical Activity: The Role of Neighbourhood Factors<br/>Building in Prevention: Nudging Towards Physical Activity and Public Health<br/>Rethinking Exposure in Area Studies on Social Inequities in Smoking in Youth and Young Adults<br/>Neighbourhood Structure and Alcohol and Other Drug Use: Implications for Prevention<br/>Neighbourhoods and Healthy Nutrition<br/>School Neighbourhoods and Obesity Prevention in Youth<br/>Connecting Gender, Space and Place: Are There Gender Differences in the Relationships Between the Social Environment and Health-Related Behaviours?<br/>From Neighbourhood and Health Research to Health Promotion Practice.

::Summary## "Concise, readable, and up to date, Nelson Essentials of Pediatrics, 9th Edition, provides the must-know information you need in pediatrics from the name you trust. A readable, full-color format; high-yield, targeted chapters; and thorough content updates ensure strong coverage of core knowledge as well as recent advances in the field. This focused resource is ideal for medical students, pediatric residents, PAs, and nurse practitioners in various educational and practice settings, including pediatric residencies, clerkships, and exams"--Publisher's description.

::Contents##<br/>Sore throat<br/>Cough<br/>Respiratory distress<br/>Earache<br/>Apparent life threatening event--brief resolved unexplained event<br/>Syncope and dizziness<br/>Chest pain<br/>Murmurs<br/>Failure to thrive<br/>Abdominal pain<br/>Diarrhea<br/>Vomiting and regurgitation<br/>Gastrointestinal bleeding<br/>Hepatomegaly<br/>Jaundice<br/>Constipation<br/>Abdominal masses<br/>Dysuria<br/>Proteinuria<br/>Hematuria<br/>Acute and chronic scrotal swelling<br/>Menstrual problems and vaginal bleeding<br/>Disorders of sex development<br/>Intellectual and developmental disability<br/>Dysmorphology<br/>Irritable infant<br/>Unusual behaviors<br/>Headaches<br/>Hypotonia, weakness, and stroke<br/>Paroxysmal disorders<br/>Altered mental status<br/>Eye disorders<br/>Arthritis<br/>Gait disturbances<br/>Back pain in children and adolescents<br/>Lymphadenopathy and neck masses<br/>Pallor and anemia<br/>Bleeding and thrombosis<br/>Fever<br/>Fever and rash<br/>Recurrent fever, infections, immune disorders, and autoinflammatory diseases<br/>Disorders of puberty<br/>Short stature<br/>Hypoglycemia<br/>Urinary incontinence and polyuria<br/>Acid--base and electrolyte disturbances<br/>Congenital cutaneous lesions and infantile rashes<br/>Acquired rashes in the older child.

::Summary## "Nelson Pediatric Symptom-Based Diagnosis, by Drs. Robert M. Kliegman, Brett Bordini, Heather Toth, and Donald Basel is intended to help the reader begin with a specific chief complaint that may be seen in many different disease entities. It is arranged in chapters that cover specific symptoms mirroring clinical practice. For example, patients do not usually present with a chief complaint of cystic fibrosis; rather, they may present with a cough, respiratory distress, or chronic diarrhea. With a user-friendly, well-tabulated, illustrated approach, this text will help the reader differentiate between the many disease states causing a common symptom."-Publisher's description.

::Summary## Nelson's Neonatal Antimicrobial Therapy is your go-to reference for treating neonates with infectious diseases. This handy reference provides evidence-based recommendations from leading experts in antimicrobial therapy for the treatment of infectious diseases in neonates.

::Summary## This book aims to provide readers with a current overview of enrolling trials with immune-checkpoint inhibitors in the preoperative setting of localized bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, providing insights into the mechanisms of response and development of resistance of cancer cells to immunotherapy. It debates optimal trial design of preoperative checkpoint inhibitors in GU tumors, including optimal endpoints and the role of pathologic response as a surrogate endpoint of survival. It also illuminates clinical management of patients with organ-confined GU tumors, such as side effect management and perioperative safety, before providing an overview of biomarker use for patient selection across the early-stage GU malignancies. Lastly, the book provides the reader with the most up-to-date data emerging from clinical trials involving immunotherapy in early-stage GU malignancies. Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers: Multidisciplinary Management provides a comprehensive review of the field, serving as a valuable resource for urologists, medical oncologists, pathologists, fellows in urologic oncology, upper-level residents training in urology and medical oncology, as well as pharmacists interested in RCC clinicians.<br/>::Contents##<br/>Introduction<br/>State-of-the art and ongoing developments<br/>Clinical cases debate: neoadjuvant checkpoint inhibition vs standard chemotherapy<br/>Slideshow of tumor samples before and after checkpoint inhibition<br/>Ongoing trials and clinical trials endpoints debate: the role of pathological response as a surrogate of survival endpoints<br/>State-of-the-art and future role of molecular biomarkers for patient selection<br/>Background of immunotherapy trials in prostate cancer<br/>Clinical case debate: immunotherapy vs alternative therapies in the neoadjuvant and adjuvant setting of localized, high-risk prostate cancer<br/>Cytoreductive nephrectomy in the era of targeted therapy and immunotherapy<br/>Clinical cases debate: Neoadjuvant vs adjuvant immunotherapy in localized RCC<br/>Benchmark of surgical safety results<br/>What the scientific data tell us about predictive biomarkers of immunotherapy efficacy across the GU malignancies<br/>Clinical cases debate: biomarker-driven patient selection vs unselective perioperative strategies.

::Contents##<br/>Neoadjuvant therapy in breast cancer / Mario Campone & Jean-Sébastien Frenel<br/>Ask the experts : neoadjuvant therapy : current options / Mark Beresford<br/>Evaluation of complete pathologic response / Audrey Mailliez, Géraldine Lauridant-Philippin & Jacques M Bonneterre<br/>Recommendation and predictors of pathologic response / Vladimir F. Semiglazov & Vladislav V. Semiglazov<br/>Combination chemotherapy and targeted agents / Victoria Brown & Stephen Chan<br/>Role of radiation after neoadjuvant chemotherapy / Michelle A. Kraay & Janice A. Lyons<br/>Monoclonal antibody therapy / Jean-Sébastien Frenel & Mario Campone<br/>Multiple choice questions : answers.

::Contents##<br/>1. Did ebola emerge in West Africa by a policy-driven phase change in agroecology?<br/>2. Ebola in the hog sector: modeling pandemic emergence in commodity livestock<br/>3. Did neoliberalizing West Africa's forests produce a vaccine-resistant ebola?<br/>4. Introducing pandemic control theory<br/>5. The social amplification of pandemics and other disasters<br/>Index.

::Contents##<br/>Fetal Skin Development<br/>Structure and Function of Newborn Skin<br/>Lesional Morphology and Assessment<br/>Skin of the Premature Infant<br/>Neonatal Skin Care and Toxicology<br/>Diagnostic and Therapeutic Procedures<br/>Transient Benign Cutaneous Lesions in the Newborn<br/>Iatrogenic and Traumatic Injuries<br/>Developmental Abnormalities<br/>Vesicles, Pustules, Bullae, Erosions, and Ulcerations<br/>Inherited and Acquired Blistering Diseases<br/>Bacterial Infections<br/>Viral Infections<br/>Fungal Infections, Infestations, and Parasitic Infections in Neonates and Infants<br/>Eczematous Disorders<br/>Papulosquamous and Lichenoid Disorders<br/>Diaper Area Eruptions<br/>Erythrodermas, Immunodeficiency, and Metabolic Disorders<br/>Disorders of Cornification (Ichthyosis)<br/>Immunologic, Reactive, and Purpuric Disorders<br/>Infantile Hemangiomas and Other Vascular Tumors<br/>Vascular Malformations<br/>Hypopigmentation Disorders<br/>Disorders of Hyperpigmentation and Melanocytes<br/>Acneiform and Sweat Gland Disorders<br/>Lumps, Bumps, and Hamartomas<br/>Disorders of the Subcutaneous Tissue<br/>Neoplastic and Infiltrative Diseases<br/>Selected Hereditary Diseases<br/>Neonatal Mucous Membrane Disorders<br/>Hair Disorders<br/>Nail Disorders.

::Summary## This book is written to simplify complex topics of neonatal and pediatric liver and metabolic diseases which are encountered by clinicians on a day to day basis. Neonatal and early pediatric liver diseases are very much different from adult liver diseases. Most of them are either structural diseases or genetically modulated metabolic disorders affecting liver. They all look same; however the underlying etiology could be quite different. This book thoroughly covers various neonatal and pediatric liver and metabolic diseases through a unique clinical case based approach via a vast clinical experience of the author. The book presents more than 50 unique cases and presents real life learning scenario with various examples facilitating better understanding of the disease and the ways to analyze it. The book uses a simple language and presents line diagrams and algorithms facilitating learning. This book shall be a valuable resource for practicing general pediatricians, pediatric residents and gastroenterologists with involvement in pediatric liver and liver related metabolic diseases. .<br/>::Contents##<br/>Neonatal and Pediatric liver Diseases<br/>Case 1: 20 month old child with recurrent convulsions<br/>Case 2: A 9 year old boy presenting with hepatitis, epistaxis and bleeding from gums<br/>Case 3: Lightening strikes at one place thrice<br/>Case 4: A worried couple with a child having jaundice<br/>Case 5: A 2 year old child who had recurrent hematemesis and bleeding per rectum<br/>Case 5: A 2 year old child who had recurrent hematemesis and bleeding per rectum<br/>Case 6: A child who had lost appetite and interest .-Case 7: A year old child with chronic diarrhea and failure to thrive<br/>Case 8: A 3 year old male with recurrent diarrhea and chest infection<br/>Case 9: 11 months old twins with Inborn errors of metabolism<br/>Case 10: A child with recurrent diarrhea<br/>Case 11: A 3 month old child with recurrent fever, diarrhea, failure to thrive and electrolyte disturbances<br/>Case 12: A 13-Year-Old girl with chronic abdominal Pain and Vomiting<br/>Case 13: A 6 month old child with neonatal cholestasis and generalized edema<br/>Case: 14. A 6 weeks old child who had progressive jaundice and creamy white stools<br/>Case: 15. Milk branding<br/>Case 16: An 8 year old son of a lady executive who was a keen "net" searcher<br/>Case 17: Neo rich parents who wanted best for their child<br/>Case 18: A case of "Criggler-Najjar syndrome"<br/>Case: 19. A pleasant child who developed prolonged jaundice<br/>Case 20: Prolonged neonatal jaundice and cardiac defects<br/>Case 21: Neonatal jaundice in a child with ocular problem<br/>Case 22: A 3 year old girl with unexplained vomiting and failure to thrive<br/>Case 23: A 3 year old boy with failure to thrive and progressively stiffening muscles<br/>Case 24: A 2 month old child with neonatal ascites<br/>Case 25: A patient with sickle cell anemia with sudden onset of jaundice<br/>Case 26: A 7 year old boy with recurrence of jaundice<br/>Case 28: An eight year old boy with recurrent jaundice<br/>Case 29: A 3 yr. old with huge liver and abnormal liver functions<br/>Case-30: A fifteen year old boy with prolonged jaundice<br/>Case-31: A young girl with recurrent jaundice and vague RUQ mass<br/>Case-32: A young boy with ascites<br/>Case 33: Two cases of recurrence of jaundice<br/>Case 34: A 12 years old boy with "obstructive jaundice<br/>Case 35: 11 years old boy with jaundice and bleeding PR<br/>Case 36: A young boy with failed renal transplant and sudden onset of ascites<br/>Case 37: A 2-Year-Old Boy with Diarrhea, Failure to thrive, and Hepatomegaly<br/>Case 38: A child with "recurrent attacks of asthma<br/>Case 39: A 3 years old boy with recurrent jaundice and severe iron deficiency anemia<br/>Case 40: 3 years old boy with huge liver<br/>Case 41: A case of neonatal liver failure<br/>Case 42: A case of acute hepatitis and ......something more<br/>Case 43: A case of neonatal hepatitis and failure to thrive<br/>Case 44: An infant with sudden onset of unilateral ptosis and jaundice<br/>Case 45: A neonate with rapidly deteriorating liver functions<br/>Case 46: A 6 month old child with hematemesis<br/>Case 47: A young child with persistent elevation of SGOT/ SGPT<br/>Case 48: An infant with persistent vomiting<br/>Case 49: A case of Fever and jaundice<br/>Case 50: A neonate with jaundice and enlarged liver<br/>Case 51: A case of huge hepatomegaly but no hypoglycemia<br/>Case 52: Pregnant lady with HBsAg positivity: A paediatrician's perspective.

::Summary## Learn to improve the respiratory care of neonates, infants, and children. Neonatal and Pediatric Respiratory Care, 5th Edition gives you a solid foundation in the assessment and treatment of respiratory disorders. Clear, full-color coverage simplifies the principles of respiratory care while emphasizing clinical application. A critical piece in respiratory care's total curriculum solution, this new edition includes all the changes in current clinical practice and in the education environment. Learning objectives at the beginning of each chapter break down key content into measurable behaviors, criteria, and conditions, and self-assessment questions provide an excellent review for the NBRC Neonatal/Pediatric Specialty exam.<br/>::Contents##<br/>I. Fetal development assessment, and delivery<br/>Fetal lung development<br/>Fetal gas exchange and circulation<br/>Antenatal assessment and high-risk delivery<br/>II. Assessment and monitoring of the neonatal and pediatric patient<br/>Examination and assessment of the neonatal and pediatric patient<br/>Pulmonary function testing and bedside pulmonary mechanics<br/>Radiographic assessment<br/>Pediatric flexible bronchoscopy<br/>Invasive blood gas analysis and cardiovascular monitoring<br/>Noninvasive monitoring in neonatal and pediatric care<br/>III. Therapeutic procedures for treatment of neonatal and pediatric disorders<br/>Oxygen administration<br/>Aerosols and administration of inhaled medications<br/>Airway clearance techniques and hyperinflation therapy<br/>Airway management<br/>Surfactant replacement therapy<br/>Noninvasive mechanical ventilation and continuous positive pressure of the neonate<br/>Noninvasive mechanical ventilation of the infant and child<br/>Invasive mechanical ventilation of the neonate and pediatric patient<br/>Administration of gas mixtures<br/>Extracorporeal membrane oxygenation<br/>Pharmacology<br/>Thoracic organ transplantation<br/>IV. Neonatal and pediatric disorders: presentation, diagnosis, and treatment<br/>Neonatal pulmonary disorders<br/>Surgical disorders in childhood that affect respiratory care<br/>Congenital cardiac defects<br/>Pediatric sleep-disordered breathing<br/>Pediatric airway disorders and parenchymal lung diseases<br/>Asthma<br/>Cystic fibrosis<br/>Acute respiratory distress syndrome<br/>Shock<br/>Pediatric trauma<br/>Disorders of the pleura<br/>Neurological and neuromuscular disorders<br/>V. Neonatal and pediatric transient and ambulatory care<br/>Transport of infants and children<br/>Home care<br/>Quality and safety.

::Summary## This is the first comprehensive book in more than a decade in the very specialized field of neonatal anesthesia. Edited and written by a team of recognized experts in neonatal anesthesia, surgery, and intensive care, this volume is the quintessential clinical reference for perioperative care of these small patients. The considerations of developmental physiology and pharmacology, which influence anesthesia care and pain management, are clearly explained. Care for surgical and medical procedures, including sedation and monitoring in and out of the operating room, is detailed. Congenital disorders of all organ systems are described together with their current management. The special considerations for neonatal intensive care ? current recommendations for fluid, nutrition, and metabolic requirements, mechanical ventilation, and management of the airway ? are detailed. This topical volume concludes with a summary of complications and ethical considerations in the neonate.<br/>::Contents##<br/>1. The History of Neonatal Anesthesia<br/>2. Physiology and Development of the term and preterm neonate<br/>3. Anesthesia and ancillary drugs & the neonate<br/>4. Selection of anesthesia techniques for the neonate<br/>5. Neonatal airway management<br/>6. Monitoring the Neonate: basic science<br/>7. Monitoring the neonate: practical considerations<br/>8. Perioperative metabolic care of the term and preterm infant<br/>9. Neonatal ventilation<br/>10. Thoracoabdominal & general surgery<br/>11. Anesthesia for the neonate: Neurosurgery & Ophthalmology<br/>12. Anesthesia for cardiac surgery in neonates<br/>13. Anesthesia outside the operating room<br/>14. Pain assessment and management<br/>15. Regional anesthesia<br/>16. Anesthetic complications in the neonate<br/>17. Ethical and medico-legal considerations.

::Summary## "Neonatal Cardiology is the trusted go-to guide for pediatricians and neonatologists needing concise, practical guidance on the evaluation and management of newborns with heart disease and other cardiac functional abnormalities. Focusing on physiology, mechanics, and presentation of congenital heart disease, this full-color resource provides a succinct, yet complete overview of neonatal cardiology. Neonatal Cardiology opens with discussions of basic aspects of embryology of the heart and a review of normal and abnormal muscle function. From there, you are led through the clinical assessment of patients with an array of cardiac abnormalities. Management and treatment follow, beginning with a basic chapter on the principles of medical management, followed by drug therapy and post-operative care. The book concludes with a chapter on Epidemiology, Etiology, and Genetics of Congenital Heart Disease"--P. 4 of cover.<br/>::Contents##<br/>Cardiac morphogenesis : implications for congenital cardiovascular diseases<br/>Myocyte contraction and relaxation<br/>Perinatal cardiovascular physiology<br/>Prenatal evaluation and management<br/>Initial evaluation of the newborn with suspected cardiovascular disease<br/>Approach to the cyanotic infant<br/>Approach to the infant with excessive pulmonary blood flow<br/>Approach to the infant with inadequate systemic perfusion<br/>Cardiomyopathies<br/>Arrhythmias<br/>Principles of medical management<br/>Cardiovascular drug therapy<br/>Care of the postoperative patient<br/>Neurology of congenital cardiovascular disease : brain development, acquired injury and neurodevelopmental outcome<br/>Epidemiology, etiology, and genetics of congenital cardiovascular disease.

::Summary## Here is a compact, easy-to-use guide to neonatal cranial ultrasonography for both the novice and experienced practitioner. It provides essential information on the procedure as well as on  normal ultrasound anatomy. Includes high-quality ultrasound images.

::Summary## This book discusses the key features of normal, age-dependent neonatal head and spine ultrasonography and the application of this modality to common and rare neonatal neurologic disorders. Ultrasonography is an incredibly versatile bedside imaging tool in detecting brain and spine abnormalities in neonates, monitoring the course of these lesions, and evaluating the maturation of the neonatal brain and spine. Organized to correspond to daily bedside practice, it presents a symptom-based approach and classifies neonatal neurologic disorders at presentation. For each disorder, clinical cases are presented that explore the differential diagnoses and are accompanied by high-quality ultrasound images that depict the abnormal findings. Topics include seizures, encephalopathy, hemiparesis, apnea, microcephaly, and neonatal spine abnormalities. Neonatal Head and Spine Ultrasonography is a succinct guide to this imaging modality and is a valuable resource for pediatric radiologists, neuroradiologists, neonatologists, and pediatricians.<br/>::Contents##<br/>Introduction<br/>Technique<br/>Normal Head Ultrasound in the Preterm and Term Newborn<br/>Seizures Encephalopathy<br/>Muscular Hypotonia<br/>Hemiplegia<br/>Apnea<br/>Microcephaly<br/>Macrocephaly<br/>Dysmorphic Facial Features<br/>Facial Skin Abnormalities.

::Summary## Neonatal hematology is a fast-growing field, and the majority of sick neonates will develop hematological problems. This is an essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values. Chapters have been thoroughly revised according to the latest advances in the field for this updated third edition. Topics discussed include erythrocyte disorders, platelet disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Coverage of oncological issues has been expanded to two separate chapters on leukemia and solid tumors, making information more easily accessible. Approaches to identifying the cause of anemia in a neonate are explained, with detailed algorithms provided to aid clinicians in practice. Covering an important hematologic niche with an ever increasing amount of specialized knowledge, this book is a valuable resource for hematologists, neonatologists and pediatricians.

::Summary## This book is designed to succinctly cover the pathophysiology, epidemiology, clinical presentation, diagnosis and treatment, and important aspects of preventative care for the most frequently encountered neonatal and congenital infections. The first section discusses common neonatal infections acquired during or after delivery, including sepsis, meningitis, necrotizing enterocolitis, and other focal infections. The second section covers a wide range of congenital infections including cytomegalovirus, hepatitis, syphilis, and HIV. The final section discusses the basics of infection prevention, outbreak management, antibiotic stewardship, and immunizations in the nursery setting. Written by an expert in infectious diseases and neonatal/perinatal medicine, this book is the only resource focused exclusively on newborns that is both current and easily accessible. Handbook of Neonatal Infections is an excellent resource for infectious disease specialists, neonatologists, pediatricians, family practitioners, medical students, hospitalists, nurses, and all clinicians caring for infants in the nursery or neonatal intensive care unit.

::Summary## "Written by leading APRN neonatal educators and clinicians, this authoritative study guide delivers all the tools neonatal nurse practitioners need to pass the National Certification Corporation (NCC) certification exam and the Continuing Competency Assessment (CCA). User friendly and concise, this review's content mirrors that of the actual exam and is structured in accordance with the most updated test plan blueprint. This resource's numerous exam-style questions and answers with rationales included in each chapter help readers uncover gaps in their knowledge. This review synthesizes the knowledge required to pass the exam, saving the reader time and effort by omitting extraneous material. In addition to spotlighting essential content throughout the text, recommended references provide the reader with the option to seek out additional information as needed. Additional benefits include important information about the exam along with savvy study and test-taking tips"--Publisher's description.<br/>::Contents##<br/>Maternal history in the antepartum<br/>Maternal history in the intrapartum<br/>The neonatal physical exam<br/>Clinical laboratory test and diagnostic procedures, techniques, and equipment use for the neonate<br/>Communication and parent/infant interaction<br/>Family integration: the grieving process<br/>Discharge planning and follow-up<br/>Thermoregulation<br/>Resuscitation and delivery room stabilization<br/>Neonatal nutrition<br/>Fluids and electrolytes<br/>Principles of neonatal pharmacology<br/>Pharmacology: common drug therapies<br/>Genetics<br/>The neurologic system<br/>The cardiac system<br/>The pulmonary system<br/>The gastrointestinal system<br/>The renal system<br/>The endocrine/metabolic system<br/>The hematopoietic system<br/>Neonatal infectious diseases<br/>The musculoskeletal system<br/>Integumentary system<br/>Eyes, ears, nose, mouth, and throat<br/>Intrauterine drug exposure<br/>Evidence-based practice<br/>Legal, ethical, and communication issues<br/>Patient safety<br/>Nursing research<br/>Final practice exam

::Summary## This textbook is written in line with the Council of International Neonatal Nurses, Inc. (COINN) vision for global unity for neonatal nursing. The core values and goals of COINN are based on excellence and advocacy for high quality newborn care, as well as respecting diversity by integrating cultural norms and values among the care of newborns and their families. The book promotes neonatal nursing as a global speciality through evidence, research, and education of neonatal nurses; and offers key examples of the millennium goals and global outcomes, as well as variations in outcomes for babies. The first part focuses on global perspectives of neonatal nursing from different continents aligning with the World Health Organizations' global regions: (The Americas -USA, Canada and South America-, Western Pacific region -Australia and New Zealand-, European region -UK and Europe-, African region, South-East Asia and Eastern Mediterranean region. For each region, education and competencies, challenges and opportunities, research and evidence-based practice (EBP) as well as practice regulations are described. The second part elaborates on key topics for neonatal nursing across the globe, such as the continuity of neonatal care in the community, patient and family centered care in neonatal settings, sleep and brain development, the fundamental care needs of the neonate and family and global perspectives on hypothermia, hypoglycaemia and hypoxia. Written in a formal academic but reader style, using key literature and evidence, this textbook enables an understanding from a large audience with academic levels and experience, both staff and students, bedside nurses, advanced practice nurses, midwifes and allied professionals. In addition, first person story based reflective narrative are interspersed throughout the book to capture the perspectives of nurses, staff and parents, in the form of vignettes. This textbook is aimed at neonatal nurses across the world as well as current and aspiring students in this field.<br/>::Contents##<br/>PART 1 Introduction<br/>Chapter 1. Introduction<br/>PART 2 Global regions<br/>Chapter 2. USA<br/>Chapter 3. Canada<br/>Chapter 4. South America<br/>Chapter 5. Australia<br/>Chapter 6. New Zealand<br/>Chapter 7. UK<br/>Chapter 8. Western Europe<br/>Chapter 9. Eastern Europe<br/>Chapter 10. South Africa<br/>Chapter 11. Eastern Africa (Rwanda)<br/>Chapter 12. Asia<br/>Chapter 13. Middle East<br/>PART 3- Key topics for neonatal nursing across the globe<br/>Chapter 14. Continuity of Neonatal Care in the Community: post-discharge care for preterm, small and sick babies<br/>Chapter 15. Patient and Family Centered Care in Neonatal Settings<br/>Chapter 16. Sleep and brain development: Developmental care strategies<br/>Chapter 17. The three Hs: Hypothermia, hypoglycaemia, hypoxia- Global perspectives on early care of the newborn<br/>Chapter 18. Psychological and emotional care for the neonate and family<br/>Chapter 19. Global research in neonatal nursing<br/>PART 4: Conclusion<br/>Chapter 20. Key messages: The way forward, next steps.

::Summary## "This education guide provides a framework for educational content and skills verification for nurses who provide evidence-based care for newborns and infants."--Publisher's description.

::Summary## "The Neonatal Nursing: Scope and Standards of Practice, 3rd Edition, is an essential document for every neonatal nurse practicing in the United States. The scope of practice statement answers the who, what, when, where, how, and why questions of neonatal nursing. The standards provide authoritative statements of the actions and behaviors that all registered neonatal nurses are expected to competently perform, regardless of role, population, specialty, and setting. The product of extensive thought work by many registered nurses, this new edition provides 17 national standards of practice and professional performance. Each standard is accompanied by detailed competencies for the three practice levels. This premier professional resource informs and guides neonatal nurses in their vital work providing safe, quality, and competent care. It is a must-have for every registered neonatal nurse"-- Provided by publisher.<br/>::Contents##<br/>Cover<br/>Title Page<br/>Copyright Page<br/>Contents<br/>Acknowledgments<br/>Scope of Neonatal Nursing Practice<br/>DEFINITION AND OVERVIEW OF PROFESSIONAL NEONATAL NURSING<br/>HISTORY OF NEONATAL NURSING<br/>UNDERLYING ASSUMPTIONS OF NEONATAL NURSING<br/>PRACTICE CHARACTERISTICS OF NEONATAL NURSING<br/>CONTINUOUS ASSESSMENT<br/>DEVELOPMENTAL CARE<br/>HEALTH PROMOTION<br/>ENVIRONMENT<br/>FAMILY-CENTERED CARE<br/>CULTURALLY SENSITIVE CARE<br/>SPIRITUAL CARE<br/>THE CODE OF ETHICS FOR NURSES<br/>DISCHARGE PLANNING<br/>ADVOCACY<br/>QUALITY ASSURANCE AND EVIDENCE-BASED PRACTICE<br/>PATIENT SAFETY<br/>RESEARCH PRACTICE ENVIRONMENTS AND LEVELS OF CARE IN NEONATAL NURSING<br/>EDUCATION, CERTIFICATION, AND ROLES IN NEONATAL NURSING<br/>FUTURE CONSIDERATIONS<br/>Standards of Practice for Neonatal Nursing<br/>Standard 1. Assessment<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse<br/>Additional Competencies for the Advanced Practice Registered Nurse<br/>Standard 2. Diagnosis<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse<br/>Additional Competencies for the Advanced Practice Registered Nurse Standard 3. Outcome Identification<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse and Advanced Practice Registered Nurse<br/>Standard 4. Planning<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse<br/>Additional Competencies for the Advanced Practice Registered Nurse<br/>Standard 5. Implementation<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse<br/>Additional Competencies for the Advanced Practice Registered Nurse<br/>Standard 5A. Coordination of Care<br/>Competencies Additional Competencies for the Graduate-Level Prepared Registered Nurse<br/>Additional Competencies for the Advanced Practice Registered Nurse<br/>Standard 5B. Health Teaching and Health Promotion<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse and Advanced Practice Registered Nurse<br/>Standard 6. Evaluation<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse and Advanced Practice Registered Nurse<br/>Standards of Professional Performance for Neonatal Nursing<br/>Standard 7. Ethics<br/>Competencies Additional Competencies for the Graduate-Level Prepared Registered Nurse and Advanced Practice Registered Nurse<br/>Standard 8. Culturally Congruent Practice<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse<br/>Additional Competencies for the Advanced Practice Registered Nurse<br/>Standard 9. Communication<br/>Competencies<br/>Additional Competencies for the Graduate-Level Prepared Registered Nurse and Advanced Practice Registered Nurse<br/>Standard 10. Collaboration<br/>Competencies

::Summary## Neonatal nurses face an ever-changing practice landscape that requires swift decisions and actions. This is an up-to-date, comprehensive, quick reference resource written specifically for neonatal nurses throughout the globe. Designed for speedy information retrieval, it encompasses vital information about commonly encountered conditions and procedures on the neonatal unit. The handbook is written by outstanding neonatal practitioners in accessible language and consistently formatted for ease of use. Illustrations, diagrams and flow charts enhance information, which is divided into sections covering Systems Assessment and Management of Disorders, Special Care Considerations, and Procedures and Diagnostic Tests. Appendices deliver such valuable tools for clinical practice as a list of common abbreviations and pertinent web resources. Also included are downloadable, digital, patient management tools, reusable templates, and quick-reference calculation tools. -- Provided by publisher.<br/>::Contents##<br/>Respiratory system / Katherine Newman<br/>Cardiovascular system / Samual Mooneyham<br/>Neurologic system / Georgia Ditzenberger, Susan T. Blackburn, Beth Brown, and Leslie Altimier<br/>Gastrointestinal system / Ann Phalen and Michele Savin<br/>Renal system / Leslie Parker<br/>Hematologic and immune systems / Carole Kenner<br/>Nutrition / Ruth Lucas, Carrie-Ellen Briere, and Ksenia Zukowsky<br/>Surgical care section / Michele DeGrazia<br/>Skin care / Carolyn Lund<br/>Developmental care / Xiaomei Cong<br/>The neonatal intensive care unit (NICU) environment / Leslie B. Altimier<br/>Palliative care / Anita Catlin, & Charlotte Wool<br/>Transition to home and primary care / Marina Boykova, & Carole Kenner<br/>Procedures / section editor, Patricia Johnson<br/>Diagnostic tests / section editor, Samual Mooneyham<br/>Common lab values / Samual Mooneyham<br/>Common drugs : medication guide / Beth Shields.

::Summary## "This handbook is a quick reference for nurses who care for the small and sick newborn. It addresses the most common conditions and procedures. The material is offered in an easy to use format and is meant to be a quick reference not a comprehensive one. It can be used by anyone providing care to this population. A systems approach is used in section I. Section II highlights special care considerations, and the final Section, III presents the common procedures, diagnostic tests, and lab values. The appendices house additional material on weights and temperatures, common abbreviations, and web resources. In this third edition, all chapters have been updated to reflect new evidence for neonatal nursing care. Additions include oral/nasogastric tube feedings, bottle feedings, high frequency ventilation and new ventilation techniques. There is a new section on Neonatal Abstinence Syndrome and Neonatal Opioid Withdrawal. This book can be used internationally to provide evidence based practice for consistent high-quality care in order to improve neonatal outcomes"-- Provided by publisher.

::Contents##<br/>PART I Delivery and Pain<br/>Gonadal Hormones and Pain Modulation<br/>Stress and Pregnancy: CRF as Biochemical Marker<br/>Pain Control During Labour<br/>PART II Fetal Pain<br/>Ultrasound and Fetal Stress: Study of the Fetal Blink-Startle Reflex Evoked by Acoustic Stimuli<br/>Prenatal Affective Exchanges and Their Subsequent Effects in Postnatal Life<br/>Pain in the Fetus<br/>New Insights into Prenatal Stress: Immediate and Long-Term Effects on the Fetus and Their Timing<br/>PART III Neonatal Pain<br/>Pain Assessment and Spectral Analysis of Neonatal Crying<br/>Analgesic Procedures in Newborns<br/>Nonpharmacological Treatment of Neonatal Pain<br/>Sensory Saturation: An Analgesic Method<br/>Pharmacologic Analgesia in the Newborn<br/>Physical Stress Risk Agents in Incubators<br/>Fetal surgery analgesia<br/>PART IV Pain: a Risk Factor for Brain Damage<br/>Neonatal Stressors<br/>New Insights into Neonatal Hypersensitivity<br/>From the Gate-Control Theory to Brain Programs for Neonatal Pain<br/>PART V Pain and Communication<br/>Disclosure of Pathology to the Newborn's Family<br/>Communication of Diagnosis: Pain and Grief in the Experience of Parents of Children with a Congenital Malformation<br/>Invest in Prenatal Life: A High-Yield Stock.

::Summary## This textbook details the nursing care of babies with life limiting conditions and sets the context within the philosophy of internationally collaborative neonatal palliative care emphasising emotional and practical support for their families. Currently, increasing interest from nursing and medical fields regarding palliative care for babies in the antenatal and neonatal period is evident. This innovative and unique text provides experienced nurses and student nurses alike with realistic guidance in caring for babies with palliative care needs, alongside the crucial support for their families and identifies important strategies for professional self care. Nursing experts in this field collaborated to develop a reference book which supports holistic and integrated clinical practice. Parents experiences of what they consider helpful or not so helpful are interwoven throughout the chapter. There is currently no other textbook which offers the above information and guidance specifically for nurses and allied health professionals. As such this book will appeal to all nurses and health professionals working within the neonatal palliative care specialty in a global context.<br/>::Contents##<br/>Foreword<br/>Part I. Achieving Quality Nursing Practice in Neonatal Palliative Care<br/>Chapter 1. Introduction to Neonatal Palliative Care<br/>Chapter 2. Exploring the Concept on Neonatal Palliative Care<br/>Chapter 3. Support for Staff: Building Resilience in Nurses<br/>Chapter 4. The Importance of Effective Communication on the Neonatal Unit<br/>Chapter 5. Spiritual, Cultural and Religious Care for the Baby and Family<br/>Chapter 6. Ethical Concepts in Neonatal Palliative Care<br/>Chapter 7. Legal Issues in Neonatal Palliative Care<br/>Chapter 8. The Principles of Genetics within Neonatal Palliative Care<br/>Chapter 9. Antenatal<br/>Chapter 10. Care of Twins and Multiple Births and Support for the Family: a Detailed Background<br/>Chapter 11. Care of Twins and Multiple Births and Support for the Family: the Butterfly Project<br/>Chapter 12. The Decision-Making Process and the Role of the Neonatal Nurse<br/>Chapter 13. Advance Care Planning<br/>Chapter 14. Organ and Tissue Donation within Neonatal Palliative and End of Life Care<br/>Chapter 15. Continuing Emotional and Practical Support for the Whole Family<br/>Chapter 16. Fundamental Principles of Effective Symptom Management in Neonatal Palliative Care<br/>Chapter 17. Collaboration between Neonatal Units and Childrens Hospices<br/>Exploring Opportunities for Potentially Improving Care and Offering Choices<br/>Chapter 18. Interdisciplinary Working in Neonatal Palliative Care<br/>Chapter 19. Developing Knowledge and Competence in Neonatal Palliative Care Practice<br/>Chapter 20. Care of the Baby after Death and Family, and Focus on Post Mortem Examination<br/>Part II. Achieving Quality in Neonatal Palliative Care Internationally<br/>Chapter 21. Introduction<br/>Chapter 22. Australia<br/>Chapter 23. Kuwait<br/>Chapter 24. India<br/>Chapter 25. Malaysia<br/>Chapter 26. South Africa<br/>Chapter 27. Ireland<br/>Chapter 28. The Netherlands<br/>Chapter 29. Germany<br/>Chapter 30. Singapore<br/>Chapter 31. Ukraine<br/>Chapter 32. Argentina<br/>Chapter 33. Italy<br/>Chapter 34. Scotland<br/>Chapter 35. France<br/>Support Organisation<br/>Index.

::Contents##<br/>Maternal-fetal medicine<br/>Normal newborn care<br/>Asphyxia and resuscitation<br/>Cardiovascular function<br/>Respiratory function<br/>Genetics and dysmophism<br/>Nutrition<br/>Renal function<br/>Endocrinology<br/>Immunology<br/>Infectious diseases<br/>Gastroenterology<br/>Dermatology<br/>Hematology and oncology<br/>Neurology<br/>Development and behavior<br/>Pediatric surgery<br/>Basic principles of pharmacology<br/>Ethics and health services delivery<br/>Core knowledge in scholarly activities.

::Contents##<br/>Influence of maturation and growth on drug metabolism from fetal to neonatal to adult life / Lindemalm, S.; van den Anker, J.N.<br/>How to translate pharmacokinetic data into dosing recommendations / Krekels, E.H.J.; Knibbe, C.A.J.; Pokorna, P.; Tibboel, D.<br/>Pharmacovigilance in neonatal intensive care / Turner, M.A.; Hill, H.<br/>Neonatal formulations and additives / Allegaert, K.; Turner, M.A.; van den Anker, J.N.<br/>Modelling and simulation to support neonatal clinical trials / Khalil, F.M.N.; Loër, S.<br/>A systematic review of paracetamol and closure of patent ductus arteriosus : are we ready for prime time? / Hammerman, C.; Mimouni, F.B.; Bin-Nun, A.<br/>Formulation of preterm formula : what's in it, and why? / Mimouni, F.B. Aviv; Mandel, D.; Lubetzky, R.<br/>Neonatal pharmacotherapy : legal and regulatory issues / Bax, R.; Tomasi, P.

::Summary## This pocket atlas explains how to use pulmonary graphics as a valuable adjunct for patient management. Actual patterns commonly encountered in neonatal practice are presented side-by-side with schematic illustrations that take apart the graphic and identify its key features, accompanied by brief explanatory text. The book addresses the principles of real-time pulmonary graphics, discusses waveforms and loops, and examines how both are affected by mechanical ventilation and disease states. A series of clinical cases brings key points to life.<br/>::Contents##<br/>1. Principles of Pulmonary Graphics<br/>2. Intro to Waveforms<br/>3. Flow Waveform<br/>4. Pressure Waveform Description Normal Abnormal Overshoot Plateau<br/>5. Volume Waveform<br/>6. Changes in Ventilator Settings and Alterations in Scalar Tracings<br/>7. Pressure-Volume Loop<br/>8. Flow-Volume Loop<br/>9. Trend screens<br/>10. Clinical scenarios<br/>11. Quiz.

::Summary## Developed by the leading experts in neonatal simulation, this innovative new resource delivers neonatology health care providers and educators essential guidance on designing, developing, and implementing simulation-based neonatal education programs.

::Summary## This comprehensive, up-to-date reference on surgery in the neonate presents and explains the latest developments in the diagnosis and treatment of neonatal malformations and surgical pathologies. The coverage includes conditions involving the head and neck and the chest, disorders of the liver and biliary tract, gastrointestinal disorders, genitourinary conditions and malformations, anterior abdominal wall defects, tumors, and various other pathologies. For each condition, the pathogenesis and the most current and innovative surgical, and also medical, approaches are described with the aid of numerous illustrations. Minimally invasive strategies receive particular attention, and tips and tricks that will be of value in clinical practice are highlighted. The book includes a general part covering topics such as embryology, anatomy, prenatal diagnosis, and anesthesia and also provides detailed advice on pre- and postoperative care, with special consideration of nutritional problems. Neonatal Surgery will serve as an excellent guide for all pediatric and neonatal surgeons, whether in training or experienced.<br/>::Contents##<br/>What is a neontal surgeon<br/>General: Perinatal physiology and general clinical characteristics of newborns. Perinatal management and care of surgical neonates (include nutritional support). Anesthesiological considerations: stabilization of the neonate, fluid administration, electrolyte balance, vascular access, ECMO, bronchoscopy, pain in neonates. Imaging in neonates. Training in neonatal surgery and simulation models. Minimal invasive surgery in the neonate<br/>Head and Neck: Choanal atresia. Facial clefts and Pierre Robin Sequence. Macroglossia. Congenital cysts and sinuses of the neck<br/>Chest: Congenital thoracic deformities. Mediastinal masses. Pneumothorax and chylothorax. Congenital malformations of the lung. Congenital diaphragmatic hernia. Esophageal atresia and congenital stenosis<br/>Gastrointestinal: Gastro-esophageal reflux. Hypertrophic pyloric stenosis and other pyloric affections. Gastric volvulus. Intestinal atresias and stenosis. Meconium ileus and peritonitis. Duplications of the alimentary tract. Mesenteric and omental cysts. Necrotizing enterocolitis. Hirschsprung's disease. Anorectal malformations. Congenital pouch colon. Inguinal hernia, cysts, hydroceles. Malrotations and volvulus<br/>Liver and Biliary Tract: Biliary atresia. Hepatic cysts. Choledocal cyst and congenital biliary dilatation. Anterior Abdominal Wall Defects: Omphalocele and gastroschisis. Omphalomesenteric duct remnants. Bladder exstrophy. Cloacal exstrophy. Prune belly syndrome<br/>Tumors: General considerations. Teratoma: cervical and sacrococcygeal. Neuroblastoma. Hepatic tumors. Wilms' tumor. Neonatal ovarian tumors<br/>Genitourinary: Hydronephrosis. Multicystic dysplastic kidney. Vesico-ureteral reflux. Ureteroceles. Posterior urethral valves. Hydrometrocolpos. DSD. Male genital anomalies. Nervous System: Surgical treatment of central nervous system malformations. Congenital CNS tumors<br/>Miscellaneous: Angioma and vascular tumors. Use of the Vacuum Assisted Closure.

::Summary## This book provides a concise yet comprehensive review of neonatal transfusion medicine. The text covers major areas of the field, including chapters dedicated to pre transfusion testing, manufacturing, standards and storage; blood product administration; special congenital and acquired disorders in the neonate; hemolytic disease of the newborn; intrauterine transfusions; adverse reactions; and ECMO. The volume features contributions from a diverse group of experts in the field and include pathologists, anesthesiologists, neonatologists, a pediatric hematologist and oncologist, and a high-risk obstetrician. These authors contribute their unique expertise and perspectives to the practice of neonatal transfusion medicine and allow the reader to experience an in depth introduction to each of the chapter topics. Neonatal Transfusion Practices is a valuable, go-to reference that addresses some of the more frequent questions asked by clinicians and professionals who have limited exposure to neonatal transfusion practices. .<br/>::Contents##<br/>Neonatal Transfusion Testing, Manufacturing, Standards and Storage<br/>Blood Product Administration<br/>Special Disease Considerations in the Neonate<br/>Hemolytic Disease of the Fetus and Newborn<br/>Intrauterine Transfusions<br/>Adverse Reactions<br/>Transfusion Considerations for Neonatal Extracoporeal Membrane Oxygenation (ECMO).

::Summary## This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.<br/>::Contents##<br/>Acute and Chronic Renal Failure in the Newborn Infant<br/>Anemia in the Neonatal Period<br/>Apnea of Prematurity and Sudden Infant Death Syndrome<br/>Bilirubin Metabolism, Unconjugated Hyperbilirubinemia, and Physiologic Neonatal Jaundice<br/>Biochemical Basis of Hypoxic-Ischemic Encephalopathy<br/>Blood Pressure Disorders in the Neonate: Hypotension and Hypertension<br/>Brain Development and Perinatal Vulnerability to Cerebral Damage<br/>Bronchopulmonary Dysplasia/Chronic Lung Disease of the Newborn<br/>Calcium and Phosphorus Homeostasis of Newborns: Pathophysiology<br/>Cardiac Emergencies in the Newborn<br/>Cardiovascular Physiology, Pathology, and Clinical Investigation in Neonatal Medicine<br/>Care of Extremely Low Birth Weight Infants and Timing of Discharge. Information and Psychosocial Intervention in Neonatology.<br/>Cerebral Hemorrhage in Newborns<br/>Cerebral Plasticity and Functional Reorganization in Children with Congenital Brain Lesions<br/>Clinical Aspects and Treatment of the Hypoxic-Ischemic Syndrome<br/>Coagulation Disorders in Newborns: Clinical Aspects of Platelet Disorders<br/>Congenital Immunodeficiencies in Newborns<br/>Congenital Malformations and Syndromes: Early Diagnosis and Prognosis in Neonatal Medicine<br/>Congenital Malformations of the Brain: Prenatal Diagnosis, Spectrum and Causes<br/>Continuous Positive Airways Pressure and other Non-Invasive Ventilation Techniques in Newborns<br/>Control of Breathing in Newborns<br/>Creactive Protein and Procalcitonin: Reference Intervals in Term and Preterm Newborns<br/>Development and General Characteristics of Preterm and Term Newborn<br/>Developmental Pharmacology and Therapeutics in Neonatal Medicine<br/>Diagnosis and Treatment of Renal and Urinary Tract Malformations in Newborns<br/>Diagnosis of Fetal Distress<br/>Disorders of Sexual Development in Newborns<br/>Early Detection of Neonatal Depression and Asphyxia<br/>Early Diagnosis of Congenital Heart Disease: When and How to Treat<br/>Early Markers of Poor Outcome in Neonatal Medicine<br/>Endocrine Diseases and Disorders of Thyroid Function in Newborns<br/>Enteral Feeding of the Very Low Birth Weight Infant<br/>Environment and Early Developmental Care for Newborns<br/>Epidemiology of Adverse Cerebral Outcome of Newborns<br/>Epidemiology: Mortality, Morbidity and Follow Up of High Risk Newborns<br/>Epigenetic Mechanisms<br/>Esophageal Atresia of Newborns<br/>Ethical Problems in Neonatal Medicine<br/>Extracorporeal Membrane Oxygenation for Neonates<br/>Feeding the Term Infant: Human Milk and Formulas<br/>Fetal and Neonatal Hydrops<br/>Fetal Infections: Congenital Syphilis and Tuberculosis<br/>Fetal Infections: Cytomegalovirus, Herpes Simplex, and Varicella<br/>Fetal infections: Rubella, HIV, HCV, HBV, and Human Parovirus B19<br/>Follow-up Outcomes of High Risk Infants<br/>Fundamentals of Feto-Neonatal Immunology and Its Clinical Relevance<br/>Gastroenteritis and Intractable Diarrhea in Newborns<br/>Gastrointestinal Malformations of Newborns<br/>Guidelines and Protocols for Newborns<br/>Hematology and Immunology of Newborns: Overview<br/>Hirschsprung's Disease in Newborns<br/>Hormones and Gastrointestinal Function of Newborns<br/>Human Milk and Formulas for Neonatal Nutrition<br/>In Vitro Fertilization and Multiple Pregnancies<br/>Inborn Errors of Metabolism and Newborns<br/>Infants of Diabetic Mothers<br/>Infants of Smoking Mothers<br/>Inflammation and Perinatal Brain Injury<br/>Inflammatory Mediators in Neonatal Asphyxia and Infection<br/>Intrauterine Growth Restriction: Obstetric and Neonatal Aspects. Intervention Strategies.<br/>Kernicterus, Bilirubin-Induced Neurological Dysfunction, and New Treatments for Unconjugated Hyperbilirubinemia in Neonates<br/>Laboratory Medicine: Reference Intervals for Laboratory Tests and Procedures<br/>Laboratory Medicine: Reference Values and Evidence Based Medicine<br/>Late Preterm Infants at Risk for Short-Term and Long Term Morbidity and Mortality<br/>Lung Diseases: Problems of Steroid Treatment of Fetus and Newborn<br/>Lung Diseases: Surfactant Replacement Therapy in Newborns<br/>Lung Ultrasounds in Neonatal Diagnostic<br/>Malformations of Cortical Development in Newborns: Genetic Aspects<br/>Meconium Aspiration Syndrome<br/>Meconium Plug Syndrome<br/>Micronutrients and Vitamins of Newborns<br/>Molecular Structure of Surfactant: Biochemical Aspects in Newborns<br/>Necrotizing Enterocolitis of Newborns<br/>Neonatal Anesthesia<br/>Neonatal Bacterial and Fungal Infections<br/>Neonatal Care in the Delivery Room: Initial Management and Approach To Low Risk Newborns<br/>Neonatal Cholestasis-Conjugated Hyperbilirubinemia<br/>Neonatal Electroencephalography<br/>Neonatal Hereditary Neutropenia<br/>Neonatal Lung Development and Pulmonary Malformations<br/>Neonatal Malignancies<br/>Neonatal Orthopedic Surgery<br/>Neonatal Pain: Neurophysiology, Recognition, Prevention and Management with Non-Pharmacological Interventions<br/>Neonatal Pulmonary Physiology of Term and Preterm Newborns<br/>Neonatal Seizures <br/>Neonatal Septic Shock<br/>Neonatal Skin Disorders<br/>Neonatal Stroke: Clinical Presentation, Imaging, Treatment, and Prognosis<br/>Neonatal Stroke: Mechanisms<br/>Neonatal Transport Services<br/>Neonatal Viral Infections: Enteroviruses and Respiratory Syncytial Virus<br/>Neonatology and the Law<br/>Neuroimaging Studies of Newborns<br/>Neurological Examination of the Newborn Infant <br/>Neuromuscular Disorders in Newborns<br/>Neuroprotective Strategies for Newborns<br/>Normal and Abnormal Neurodevelopmental and Behavioral Outcomes of Very Low-Birth Weight (VLBW) Infants<br/>Nutritional Recommendations for the Very Low Birth Weight Newborn<br/>Ocular Malformations in Newborns<br/>Organization of Perinatal Care. Training of Doctors and Nurses<br/>Orofacial Malformations<br/>Oxygen Saturation Monitoring in Neonatal Period<br/>Oxygen Toxicity in Newborns<br/>Parenteral Nutrition of Newborns<br/>Patent Ductus Arteriosus in Newborns<br/>Pathologic Unconjugated Hyperbilirubinemia, Isoimmunization, Abnormalities of Red Blood Cells, and Infections<br/>Pathology and Treatment of Liver Diseases in Newborns<br/>Pathophysiology of Coagulation and Deficiencies of Coagulation Factors in Newborns<br/>Pathophysiology of Fetal and Neonatal Kidneys<br/>Persistent Pulmonary Hypertension of the Newborn and Congenital Diaphragmatic Hernia: Nitric Oxide Therapy in Neonatology<br/>Physical Environment for Newborns: the Thermal Environment<br/>Physical Examination of the Newborn<br/>Physiology and Abnormalities of Leukocytes in Newborns<br/>Physiology of the Gastrointestinal Tract in Newborns<br/>Polycythemia and Hyperviscosity in Neonates<br/>Post-Discharge Nutrition in Preterm Infants<br/>Prenatal and Postnatal Inflammatory Mechanisms<br/>Primary Investigations in the Term and Preterm Newborn<br/>Problems of Discharge and Home Care of Newborns<br/>Pulmonary Air Leakage in Newborns<br/>Pulmonary Hemorrhage, Transient Tachypnea and Neonatal Pneumonia<br/>Quality of Neonatal Intensive Care and Outcome for High Risk Newborn Infants<br/>Rare Lung Diseases of Newborns<br/>Rare Surgical Emergencies of Newborns<br/>Recombinant G-CSF Treatment of Severe Chronic Neutropenia in Neonates and Infants<br/>Rehydration after Diarrhea in Newborns<br/>Respiratory Distress Syndrome: Predisposing Factors, Pathophysiology, and Diagnosis<br/>Resuscitation of the Newborn<br/>Retinopathy of Prematurity<br/>Risk Factors for Gestational Diseases<br/>Risk Management of Newborns<br/>Safety of Medications During Pregnancy and Breastfeeding: Infants of Drug-Addicted Mothers<br/>Surfactant Metabolism in Neonatal Lung Diseases<br/>Surgical Treatment in Newborns of Necrotizing Enterocolitis<br/>Surgical Treatment of Biliary Tract Malformations in Newborns<br/>The Fetus at Risk: Chorioamnionitis<br/>The Process of Decision-Making in Neonatology<br/>The Thrombotic Risk of the Newborn<br/>The Timing of Neonatal Brain Damage<br/>Toxoplasmosis in the Fetus and in the Newborn<br/>Treatment of Hyperbilirubinemia in Newborns<br/>Treatment of Respiratory Failure in Newborn: Mechanical Ventilation<br/>Vaccinations and Neonatal Immunity.- .

::Summary## "Understand the fundamental principles of neonatology and learn evidence-based care strategies. With coverage that strikes the perfect balance between proven management approaches and fundamental principles, this unique resource combines the benefits of a comprehensive neonatology textbook with a practical procedural guide. You will get a detailed step-by-step instruction on diagnosis, management, and treatment of acute problems of the newborn as organized by organ system, based on the highest level of evidence available, along with a thorough review of topics such as epidemiology, ethics, legal issues in the NICU, monitoring devices, fluid requirements, and enteral nutrition."--Publisher's website.

::Summary## This 7th edition provides practical and easily accessible information on the basic and advanced management of the neonate in a logical outline approach. All neonatal procedures, disorders, and pharmacology are covered, highlighting essential information. Features: provides quick answers to both common and rare clinical issues; the popular "On-Call Problems" section details more than 30 of the most common and critical clinical conditions faced in the NICU; comprehensive pharmacology section includes indications and use, actions, means of delivery, dosages, possible adverse effects for over 150 drugs.<br/>::Contents##<br/>Fetal assessment<br/>Obstetric anesthesia and the neonate<br/>Resuscitation of the newborn<br/>Infant transport<br/>Gestational age and birthweight classification<br/>Newborn physical examination<br/>Temperature regulation<br/>Respiratory management<br/>Fluid and electrolytes<br/>Nutritional management<br/>Imaging studies<br/>Management of the extremely low birthweight infant during the first week of life<br/>Management of the late preterm infant<br/>Pain in the neonate<br/>Newborn screening<br/>Studies for neurologic evaluation<br/>Blood component therapy<br/>Extracorporeal life support in the neonate<br/>Follow-up of high-risk infants<br/>Complemenatary and alternative medical therapies in neonatology<br/>Neonatal bioethics<br/>Apnea<br/>Bronchopulmonary dysplasia/chronic lung disease<br/>Calcium disorders (hypocalcemia, hypercalcemia)<br/>Chlamydial infection<br/>Coagulation disorders<br/>Common multiple congenital anomaly syndromes<br/>Congenital heart disease<br/>Cytomegalovirus<br/>Disorders of sex development<br/>Enteroviruses and parechoviruses<br/>Eye disorders of the newborn<br/>Gonorrhea<br/>Hepatitis<br/>Herpes simplex viruses<br/>Human immunodeficiency virus<br/>Hydrocephalus and ventriculomegaly<br/>Hyperbilirubinemia, direct (conjugated hyperbilirubinemia)<br/>Hyperbilirubinemia, indirect (unconjugated hyperbilirubinemia)<br/>Inborn errors of metabolism with acute neonatal onset<br/>Infant of a diabetic mother<br/>Infant of substance-abusing mother<br/>Intracranial hemorrhage<br/>Intrauterine growth restriction (small for gastational age)<br/>Lyme disease<br/>Magnesium disorders (hypomagnesemia, hypermagnesemia)<br/>Meconium aspiration<br/>Meninigitis<br/>Methicillin-resistant staphylococcus aureus infections<br/>Multiple gestation<br/>Myasthenia gravis (transient neonatal)<br/>Necrotizing enterocolitis<br/>Neural tube defects<br/>Orthopedic and musculoskeletal problems<br/>Osteopenia of prematurity. Parvovirus B19 infection<br/>Patent ductus arteriosus<br/>Perinatal asphyxia<br/>Persistent pulmonary hypertension of the newborn<br/>Pertussis<br/>Polycythemia and hyperviscosity<br/>Renal failure, acute (acute kidney injury)<br/>Respiratory distress syndrome<br/>Respiratory syncytial virus<br/>Retinopathy of prematurity<br/>Rh incompatibility<br/>Rubella<br/>Seizures<br/>Sepsis<br/>Spontaneous intestinal perforation<br/>Surgical diseases of the newborn: abdominal masses<br/>Surgical diseases of the newborn: abdominal wall defects<br/>Surgical diseases of the newborn: alimentary tract obstruction<br/>Surgical diseases of the newborn: diseases of the airway, tracheobronchial tree, and lungs<br/>Surgical diseases of the newborn: retroperitoneal tumors<br/>Surgical diseases of the newborn: urologic disorders<br/>Syphilis<br/>Thrombocytopenia and platelet dysfunction<br/>Thyroid disorders<br/>TORCH infections<br/>Toxoplasmosis<br/>Transient tachypnea of the newborn<br/>Tuberculosis<br/>Ureaplasma infection<br/>Urinary tract infection<br/>Varicella-Zoster infections<br/>Medications used in the neonatal intensive care unit<br/>Effects of drugs and substances on lactation and infants<br/>Appendices: Appendix A: Abbreviations used in neonatology<br/>Appendix B: Apgar scoring<br/>Appendix C: Blood pressure determinations<br/>Appendix D: Chartwork<br/>Appendix E: Immunization tables<br/>Appendix F: Isolation guidelines<br/>Appendix G: Temperature conversion table<br/>Appendix H: Weight conversion table.

::Summary## This book provides a thorough overview of the radiologic and pathologic findings of neoplastic diseases of the biliary tract, a sound knowledge of which is essential for appropriate patient management. A key feature is the correlation of imaging findings with both gross pathologic and histopathologic findings for each disease. This is of the utmost importance in understanding true pathologic abnormalities, bearing in mind, for example, the difficulty in ascertaining disease spread and extent on the basis of pathology alone. Since the first edition of the book, conceptual understanding of neoplastic disease of the bile ducts and cholangiocarcinogenesis has evolved significantly, and in the new edition the classification of diseases is based on the most recent edition of the WHO Classification of Tumors of the Digestive System. In addition, some newly recognized pathologies are covered. The book will enhance understanding of the pathology of neoplastic diseases of the biliary tract and aid imaging interpretation. It will be a great asset for pathologists, radiologists, biliary surgeons, and gastroenterologists.<br/>::Contents##<br/>1. Anatomy of the Biliary Tract<br/>2. Bile Duct Cysts<br/>3. Cystic Neoplasms<br/>4. Benign Neoplasms of the Bile Ducts<br/>5. Precursors of Cholangiocarcinoma<br/>6. Intraductal Papillary Neoplasm of the Bile Ducts<br/>7. Cholangiocarcinoma<br/>8. Tumors of the Gallbladder<br/>9. Tumors of the Ampulla Vater and Duodenal Papilla.

::Summary## Neoplastic Diseases of the Blood" integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia - Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.<br/>::Contents##<br/>A history of the chronic leukemias / John M. Goldman and Myrtle Y. Gordon<br/>Etiology and epidemiology of chronic myeloid leukemia / Maren Rohrbacher and Joerg Hasford<br/>Pathology of the chronic myeloid leukemias / Barbara J. Bain<br/>Molecular biology and cytogenetics of chronic myeloid leukemia / Alfonso Quintás Cardama, Hagop Kantarjian, and Jorge Cortes<br/>Diagnosis and treatment of chronic myeloid leukemia / Stephen G. O'Brien and John M. Goldman<br/>Etiology and epidemiology of CLL / Dalemari Crowther-Swanepoel, Daniel Catovsky, and Richard S. Houlston<br/>Histopathology, morphology, and immunophenotyping of CLL / Abraham M. Varghese ... [et al.]<br/>Molecular biology and cytogenetics of chronic lymphocytic leukemia / David Oscier, Anne Gardiner, and Jonathan C. Strefford<br/>Treatment of chronic lymphocytic leukemia and related disorders / Gautam Borthakur and Susan O'Brien<br/>Hairy cell leukemia / Sejal A. Jhatakia, Darren S. Sigal, and Alan Saven<br/>The pathogenesis, diagnosis, and treatment of polycythaemia vera / Mark A. Dawson and Brian J.P. Huntly<br/>Diagnosis and treatment of essential thrombocythemia and primary myelofibrosis / John T. Reilly<br/>History of acute leukemia / Emil J. Freireich<br/>The etiology of acute leukemia / Jessica N. Nichol, Sarit Assouline, and Wilson H. Miller<br/>Epidemiology and hereditary aspects of acute leukemia / Martha S. Linet ... [et al.]<br/>Classification of the acute leukemias : cytochemical and morphologic considerations / Nukhet N. Tuzuner and John M. Bennett<br/>Immunobiology of acute leukemia / Elisabeth Paietta<br/>Cytogenetics of acute leukemia / Nyla A. Heerema and Susana Catalina Raimondi<br/>Diagnosis and treatment of childhood acute lymphoblastic leukemia / Dario Campana and Ching-Hon Pui<br/>Diagnosis and treatment of adult acute lymphoblastic leukemia / Nicola Goekbuget and Dieter Hoelzer<br/>Diagnosis and treatment of childhood acute myeloid leukemia / David A. Sweetser and Howard J. Weinstein<br/>Diagnosis and treatment of adult acute myeloid leukemia other than acute promyelocytic leukemia / Peter H. Wiernik<br/>Acute promyelocytic leukemia / Peter H. Wiernik, Robert E. Gallagher, and Martin S. Tallman<br/>Therapy-related acute myelogenous leukemia / Gabriela Bernadeta Iwanski ... [et al.]<br/>The myelodysplastic syndromes / Kenneth Miller and Igor Rozenvald<br/>History of multiple myeloma / David P. Steensma and Robert A. Kyle<br/>Cytokines and signal transduction in multiple myeloma / Dharminer Chauhan and Kenneth C. Anderson<br/>Epidemiology of multiple myeloma / Dalsu Baris ... [et al.]<br/>Immunoglobulins and laboratory recognition of monoclonal proteins / Jerry Katzmann ... [et al.]<br/>Cytogenetic abnormalities in MGUS and myeloma / Rafael Fonseca, P. Leif Bergsagel, and W. Michael Kuehl<br/>Molecular genetics of myeloma / Brian Van Ness<br/>Prognosis and staging of multiple myeloma / Jesús F. San-Miguel, Ramón García-Sanz, and Norma C. Gutiérrez<br/>Diagnosis and treatment of multiple myeloma / S. Vincent Rajkumar and Robert A. Kyle<br/>Complications and special presentations of plasma cell myeloma / Joan Blad́e and Laura Rosiñol<br/>Waldenström's macroglobulinemia / Efstathios Kastritis and Meletios A. Dimopoulos<br/>Heavy-chain disease / Dietlind L. Wahner-Roedler and Robert A. Kyle<br/>Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis) / Morie A. Gertz and Robert A. Kyle<br/>Monoclonal gammopathy of undetermined significance / Robert A. Kyle and S. Vincent Rajkumar<br/>Historical landmarks in the understanding of the lymphomas / Marshall A. Lichtman<br/>Genetics in lymphomagenesis / Sigurdur Y. Kristinsson ... [et al.]<br/>Epidemiology and hereditary aspects of Hodgkin and non-Hodgkin lymphomas / Seymour Grufferman<br/>Pathology of non-Hodgkin's and Hodgkin's lymphomas / L. Jeffrey Medeiros<br/>Immunology of the lymphomas / Carla Kurkjian and Howard Ozer<br/>Cytogenetics of lymphomas / Meaghan Wall and Lynda J. Campbell<br/>Diagnosis and treatment of Hodgkin's lymphoma / Peter H. Wiernik, Monica Balzarotti, and Armando Santoro<br/>Radiotherapeutic management of lymphomas / John P. Plastaras ... [et al.]<br/>Diagnosis and treatment of non-Hodgkin's lymphoma of adults / Edward A. Faber, Jr. ... [et al.]<br/>Non-Hodgkin lymphoma of childhood / Tony H. Truong, Sheila Weitzman, and Robert J. Arceci<br/>Lymphoma in other diseases / William B. Ershler, Barbara K. Dunn, and Dan L. Longo<br/>Supportive care for patients with leukemia : a historical perspective / Charles A. Schiffer<br/>Prevention of infections in patients with hematological malignancies / Marcio Nucci ... [et al.]<br/>Evaluation and management of bacterial and fungal infections occurring in patients with a hematological malignancy : a 2011 update / James C. Wade<br/>Viral infections in patients with hematological malignancies / Jack W. Hsu ... [et al.]<br/>Therapuetic cytapheresis, plasmapheresis, and plasma exchange in neoplastic diseases of the blood / Janice P. Dutcher<br/>Red cell transfusions in patients with hematologic malignancies / Karen E. King and Paul M. Ness<br/>Platelet and granulocyte transfusion / Janice P. Dutcher<br/>Alternative sources of hematopoietic stem cells and their clinical applications / Jonathan A. Gutman, Shelly Heimfeld, and H. Joachim Deeg<br/>HLA typing in support of hematopoietic cell transplantation from unrelated donors / Effie W. Petersdorf ... [et al.]<br/>Special care of blood and marrow stem transplant patients / Hillard M. Lazarus, Lisa M. Arfons, and Richard J. Creger<br/>Hematopoietic growth factors in the supportive care and treatment of patients with hematologic neoplasms / Belinda R. Avalos and Edward A. Copelan<br/>Bleeding and thrombosis in hematologic neoplasia / Aleksandra Ciszewski and Thomas DeLoughery<br/>Psychological aspects of hematological neoplasms / Tomer T. Levin.

::Summary## The new edition of this textbook integrates the history, epidemiology, pathology, pathophysiology, therapeutics, and supportive care of modern neoplastic hematopathology. Now in its sixth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. The textbook is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia, including chronic leukemias and related disorders, acute leukemias, myeloma and related disorders, and lymphomas, and the fifth section covering a variety of topics in supportive care. Chapters are presented in an accessible and easy-to-read layout, providing updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. Neoplastic Diseases of the Blood, Sixth Edition is an authoritative and indispensable resource for students, trainees, and clinicians, sure to distinguish itself as the definitive reference on this subject.<br/>::Contents##<br/>A History of the Chronic Leukemias<br/>Epidemiology and Etiology of Chronic Myeloid Leukemia<br/>Pathology of the Chronic Myeloid Leukemias<br/>Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia<br/>Diagnosis and Treatment of Chronic Myeloid Leukemia<br/>Etiology and Epidemiology of CLL<br/>Morphology and Immunophenotype of CLL<br/>The Genomic and Epigenomic Landscape of Chronic Lymphocytic Leukemia<br/>Treatment of Chronic Lymphocytic Leukemia and Related Disorders<br/>Hairy Cell Leukemia<br/>History of Acute Leukemia<br/>The Etiology of Acute Leukemia<br/>Epidemiology and Hereditary Aspects of Acute Leukemia<br/>Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations<br/>Immunobiology of Acute Leukemia<br/>Cytogenetics of Acute Leukemia<br/>Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia<br/>Diagnosis and Treatment of Adult Acute Lymphocytic Leukemia<br/>Diagnosis and Treatment of Acute Myeloid Leukemia in Children<br/>Diagnosis and Treatment of Adult Acute Myeloid Leukemia Other than Acute Promyelocytic Leukemia<br/>Acute Promyelocytic Leukemia<br/>Therapy-Related Acute Myelogenous Leukemia<br/>The Myelodysplastic Syndromes<br/>History of Multiple Myeloma<br/>Monoclonal Gammopathy of Undetermined Significance<br/>Smoldering Multiple Myeloma<br/>Newly Diagnosed Multiple Myeloma in Frail Patients<br/>Newly Diagnosed Multiple Myeloma in Transplant Eligible Patients<br/>Role of Hematopoietic Cell Transplantation for Myeloma<br/>Solitary Plasmacytomas and Soft-Tissue Involvement in Multiple Myeloma<br/>Supportive Care in Multiple Myeloma<br/>POEMS Syndrome<br/>Waldenstrom's Macroglobulinemia<br/>Plasma Cell Leukemia<br/>Prognosis of Myeloma/Genetics of Myeloma<br/>Immunoglobulin Light Chain Amyloidosis (AL)<br/>Historical Landmarks in an Understanding of the Lymphomas<br/>Genetics in Lymphomagenesis<br/>Epidemiology and Hereditary Aspects of Hodgkin and Non-Hodgkin Lymphomas<br/>Pathology of Non-Hodgkin and Hodgkin Lymphomas<br/>Immunology of the Lymphomas<br/>Cytogenetics of Lymphomas<br/>Diagnosis and Treatment of Hodgkin Lymphoma<br/>Radiotherapeutic Management of Lymphomas<br/>Diagnosis and Treatment of Non-Hodgkin's Lymphoma of Adults<br/>Non-Hodgkin Lymphoma of Childhood<br/>Lymphoma in Other Diseases<br/>Supportive Care for Patients with Leukemia: A Historical Perspective<br/>Prevention of Infections in Patients with Hematological Malignancies<br/>Evaluation and Management of Bacterial and Fungal Infections in Patients with a Hematological Malignancy: A 2016 Update<br/>Viral Infections in Patients with Hematological Malignancies<br/>Therapeutic Cytapheresis, Plasmapheresis, and Plasma Exchange in Neoplastic Diseases of the Blood<br/>Red Cell Transfusions in Patients with Hematologic Malignancies<br/>Platelet and Granulocyte Transition<br/>Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications<br/>HLA Typing in Support of Hematopoietic Cell Transplantation from Unrelated Donors<br/>Special Care of Blood and Marrow Hematopoietic Cell Transplant Recipient<br/>Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with Hematologic Neoplasms<br/>Bleeding and Thrombosis in Hematologic Neoplasia<br/>Psychological Aspects of Hematological Neoplasms.

::Summary## This book provides a comprehensive overview of the patterns of biodiversity in various neotropical ecosystems, as well as a discussion on their historical biogeographies and underlying diversification processes. All chapters were written by prominent researchers in the fields of tropical biology, molecular ecology, climatology, paleoecology, and geography, producing an outstanding collection of essays, synthetic analyses, and novel investigations that describe and improve our understanding of the biodiversity of this unique region. With chapters on the Amazon and Caribbean forests, the Atlantic rainforests, the Andes, the Cerrado savannahs, the Caatinga drylands, the Chaco, and Mesoamerica - along with broad taxonomic coverage - this book summarizes a wide range of hypotheses, views, and methods concerning the processes and mechanisms of neotropical diversification. The range of perspectives presented makes the book a truly comprehensive, state-of-the-art publication on the topic, which will fascinate both scientists and general readers alike.<br/>::Contents##<br/>Chapter 1. Introduction<br/>Part 1. Neotropical diversity and diversification<br/>Chapter 2. Neotropical diversification: historical overview and conceptual insights<br/>Chapter 3. Beyond refugia: New insights on Quaternary climate variation and the evolution of biotic diversity in tropical South America<br/>Chapter 4. Tropical and subtropical in South America: a study of community turnover across environmental gradients<br/>Chapter 5. Evolutionary macroecology and the geographical patterns of Neotropical diversification<br/>Chapter 6. Evolutionary imprints on species distribution patterns across the Neotropics<br/>Chapter 7. Avian diversity in humid tropical and subtropical south American forests, with a discussion about their related climatic and geological underpinnings<br/>Chapter 8. Contrasting patterns of temporal diversification in Neotropical butterflies: An overview<br/>Chapter 9. Diatom diversity and biogeography across tropical South America<br/>Part 2. Regional biodiversity patterns and diversification processes<br/>Chapter 10. The origin and evolution of Amazonian species diversity<br/>Chapter 11. Patterns and processes of diversification in Amazonian white sand ecosystems: insights from birds and plants<br/>Chapter 12. Human contribution to Amazonian plant diversity: legacy of pre-Columbian land use in modern plant communities<br/>Chapter 13. On the young savannas in the land of ancient forests<br/>Chapter 14. The diversification of extant Angiosperms in the South America dry diagonal<br/>Chapter 15. Diversity, endemism, and evolutionary history of montane biotas outside the Andean region<br/>Chapter 16. Patterns of species and lineage diversity in the Atlantic rainforest of Brazil<br/>Chapter 17. Diversification in ancient and nutrient-poor Neotropical ecosystems: how geological and climatic buffering have shaped plant diversity in some of the worlds neglected hotspots<br/>Chapter 18. Bioregions of Eastern Brazil, based on vascular plant occurrence data<br/>Chapter 1 9. Forests diversity in the Mexican neotropics: A paleocological view<br/>Chapter 20. Historical biogeography of Caribbean plants revises regional paleogeography<br/>Part 3. Taxon-based local and regional studies<br/>Chapter 21. Amphibians and reptiles of Venezuelan Guayana: diversity, biogeography and conservation<br/>Chapter 22. Origin of elevational replacements in a clade of nearly flightless birds<br/>most diversity in tropical mountains accumulates via secondary contact following allopatric speciation<br/>Chapter 23. Clade-specific biogeographic history and climatic niche shifts of the southern Andean-southern Brazilian disjunction in plants<br/>Chapter 24. Biotic and landscape evolution in an Amazonian contact zone: insights from the herpetofauna of the Tapajós River basin<br/>Chapter 25. Diversification processes in lizards and snakes from the middle São Francisco River dune region<br/>Chapter 26. Unexpected beta-diversity radiations in highland clades of Andean Terraranae frogs<br/>Chapter 27. Disparate patterns of diversification within Liolaemini lizards<br/>Chapter 28. Diversification history of Neotropical Lecythidaceae, an ecologically dominant tree family of Amazon rain forest<br/>Part 4. IV. Epilogue<br/>Chapter 29. Conservation in the Neotropics<br/>a final reflection.

::Summary## This pioneering book focuses on Neotropical endophytic fungi, providing a comprehensive overview of their diversity, ecology, and biotechnological applications in medicine, agriculture, and industry. Despite their rich diversity, the endophytic fungi associated with plants of Central and South American biomes remain largely unknown. The book addresses that knowledge gap by offering insights into Neotropic endophytic fungal community.<br/>::Contents##<br/>Neotropical endophytic fungi: isolation, diversity, and biogeography of Neotropical endophytic fungi<br/>Ecology of Neotropical endophytic fungi<br/>Diversity, ecology and applications of Epichloë fungal endophytes of grasses in South America<br/>Endophytes from unique ecosystems in Chile: challenge and opportunities for biodiversity and biotechnological applications<br/>Endophytic fungal community associated with Colombian plants<br/>Fungal endophytes and bioactive compounds from tropical forests of Costa Rica<br/>Diversity of endophytic fungi in Brazilian biomes Rupestrian Grasslands, Caatinga, Pampa, and Pantanal<br/>Endophytic fungi of the Cerrado: Diversity and its role in ecological interactions and environmental conservation<br/>Endophytic fungi associated with medicinal plants of Amazonian forest<br/>Endophytic fungi associated with ancient Neotropical plants<br/>Bioprospecting of Neotropical endophytic fungi in South America applied to medicine<br/>Bioprospecting of Neotropical endophytic fungi applied to agriculture<br/>Endophytic fungi associated with Neotropical plants: a source of promising macromolecules for use in biotechnology<br/>Potential use of Neotropical endophytic fungi in green synthesis of nanoparticles using endophytes<br/>Bioprospecting of secondary bioactive metabolites produced by endophytic fungi of the medicinal Piper sp. in the Brazilian Tropical Rain Forest<br/>Diversity of endophytic fungi of Empetrum rubrum Vahl ex Willd (Ericaceae), a medicinal plant from austral South America.

::Summary## Ethnoprimatology is situated at the intersection between the biological and cultural subfields of anthropology. Research on the interface between human and nonhuman primates has been steadily increasing since 1997, when the term ethnoprimatology was first coined. Although there have been studies on human-nonhuman primate interactions in the tropical Americas, no single comprehensive volume has been published that integrates this information to fully understand it in this region. Eighteen novel chapters written by outstanding scholars with various backgrounds are included in this edited volume. They refer to the complex interconnections between different indigenous peoples with New World monkeys that sympatrically share their ancestral territories. Geographically, the range covers all of the Neotropics, from southern Mexico through northern Argentina. This work includes topics such as primates as prey and food, ethnozoology/ethnoecology, cosmology, narratives about monkeys, uses of primates, monkeys as pets, and ethnoclassification. Multiple views as well as diverse theoretical and methodological approaches are found within the pages. In sum, this is a compendium of ethnoprimatological research that will be prized by anthropologists, ethnobiologists, primatologists, conservationists, and zoologists alike. "This book ... provides a historical benchmark for all subsequent research in ethnoprimatology in the Neotropics and beyond."--Leslie E. Sponsel, University of Hawaiþi at Mānoa.<br/>::Contents##<br/>Intro<br/>Foreword<br/>References<br/>Neotropical Ethnoprimatology: An Introduction<br/>References<br/>Acknowledgments<br/>Contents<br/>Contributors<br/>About the Editors<br/>Part I: Mesoamerica<br/>Chapter 1: Perception and Uses of Primates Among Popoluca Indigenous People in Los Tuxtlas, Mexico<br/>1.1 Introduction<br/>1.2 Methods<br/>1.3 Results<br/>1.3.1 Cultural and Traditional Aspects About Primates<br/>1.3.2 Emotive Perceptions About Primates<br/>1.3.3 Medicinal Use of Primates<br/>1.3.4 Use of Primates as Pets<br/>1.3.5 Use of Primates as Food<br/>1.3.6 Economic Uses and Perceptions About Primates 1.3.7 Perceived Ecological Importance of Primates<br/>1.3.8 Perceived Abundance and Distribution of Primates<br/>1.3.9 Perceived Threats to the Conservation of Primates<br/>1.3.10 Interest in Primate Conservation<br/>1.4 Discussion<br/>References<br/>Chapter 2: Mental State Attribution to Nonhuman Primates and Other Animals by Rural Inhabitants of the Community of Conhuas Near the Calakmul Biosphere Reserve in the Yucatan Peninsula, Mexico<br/>2.1 Introduction<br/>2.2 The Present Study<br/>2.3 Results<br/>2.3.1 The Folk Psychology of Basic Emotions<br/>2.3.1.1 Anger<br/>2.3.1.2 Fear<br/>2.3.1.3 Pain 2.3.1.4 Joy<br/>2.3.2 The Folk Psychology of Complex Mental States<br/>2.3.2.1 Thinking, Intelligence, and Deceit<br/>2.3.2.2 Deceit<br/>2.4 Discussion<br/>2.5 Acknowledgments<br/>Appendix 1: Sociodemographic Information of Participants<br/>Appendix 2: List of Animal Cards Shown to Participants<br/>References<br/>Chapter 3: Local Knowledge and Cultural Significance of Primates (Ateles geoffroyi and Alouatta pigra) Among Lacandon Maya from Chiapas, Mexico<br/>3.1 Introduction<br/>3.2 The Lacandon Maya from Naha and Metzabok and Their Environment<br/>3.2.1 The Lacandon<br/>3.2.2 The Lacandon Environment 3.3 Monkeys in the Ancient Maya<br/>3.3.1 The Origin of Monkeys<br/>3.3.2 The Monkey: Lord of Writing<br/>3.3.3 Monkeys as Wahyis (Powerful Supernatural Spirits)<br/>3.3.4 Monkey-Cacao (Chocolate) Associations<br/>3.3.5 Primate Representations in the Archaeological Record<br/>3.4 Current Local Knowledge and Cultural Significance of Non-human Primates<br/>3.5 Conclusions<br/>References<br/>Chapter 4: Representation and Signification of Primates in Maya-Q'eqchi' Cosmovision and Implications for Their Conservation in Northwestern Guatemala<br/>4.1 Introduction<br/>4.2 Study Area 4.3 Primates and Our Participatory Conservation Work<br/>4.4 Representation and Signification of Primates in Maya-Q'eqchi' Culture and Cosmovision<br/>4.4.1 Origin of Primates<br/>4.4.2 Family Lineages, Surnames, and Proper Names<br/>4.4.3 Sacred Mayan Calendar and the Nahual B'atz'<br/>4.4.4 Art<br/>4.4.5 Language<br/>4.4.6 Uses and Attitudes<br/>4.5 Implications for Primate and Habitat Conservation<br/>4.6 Final Considerations<br/>References<br/>Part II: South America<br/>Chapter 5: Ethnoprimatology of the Tikuna in the Southern Colombian Amazon<br/>5.1 Introduction<br/>5.2 The Tikuna

::Summary## This book provides updated information on this intriguing and exciting group of insects: Neotropical Social Wasps. These insects have a particular biology and their colonies are formed by a few cooperative females living in either small or massive, structured nests where stinging individuals organize their activities and defend their offspring. Topics include evolutionary aspects, biogeography, post-embryonic development, community behavior and ecology, economic importance, and research methods.<br/>::Contents##<br/>A Brief Review Of Studies On Social Wasps In Brazil<br/>The Evolution of Swarm Founding in the Wasps: Possible Scenarios<br/>The foraging behaviour of neotropical social wasps<br/>The choice of sexual partner in social wasps<br/>Nesting Habits of Neotropical Social Wasps<br/>Castes and polymorphisms in neotropical social wasps<br/>The biology of swarm-founding epiponine wasp, Polybia paulsita<br/>Causes and consequences of reproductive conflicts in wasp societies<br/>Post-embryonic Development in Brazilian Social Wasps<br/>Evolution and adaptation of the wings and mandibles of neotropical social wasps<br/>Cuticular hydrocarbon studies in Neotropical Social Wasps<br/>Biogeographic hypotheses for the Neotropical Social Wasps<br/>Chromosome diversity and evolution in Neotropical social wasps<br/>Phylogeny and classification of the Neotropical social wasps<br/>List of species of social wasps from Brazil<br/>The Old-World versus New-World social wasps: Similarities, differences and threats<br/>Key to the genera of social wasps (Polistinae) occurring in Brazil<br/>Research techniques used in the study of social wasps<br/>Community ecology of social wasps in Brazil: Forty years of studies<br/>lnteractions between wasps and other animals: associations and natural enemies<br/>Interactions of social wasps with microorganisms<br/>Artificial Environments for Studying Eusocial Wasps<br/>Economic importance of Neotropical Social Wasps.

::Summary## This book offers a comprehensive overview of neovascular glaucoma (NVG), which is an extraordinarily aggressive type of secondary glaucoma that has often been discussed as an afterthought rather than the focal subject in glaucoma reference books. NVG is considered an end stage complication in patients with certain underlying retinal diseases, most commonly diabetic retinopathy and retinal vein occlusions. Historically, NVG has been one of the most difficult types of glaucoma to manage, with a high failure rate for traditional glaucoma surgery, and often progression of the underlying retinal disease despite "standard of care" treatment. Chapters cover advancements made in recent years in the management of the underlying ischemic retinal conditions that lead to NVG, including the use of anti-vascular endothelial growth factor (anti-VEGF) medications. Additionally, chapters discuss glaucoma surgeries, which have become less invasive in recent years with the advent of microinvasive glaucoma surgery (MIGS). This book offers an up-to-date reference regarding current concepts in the diagnosis, as well as medical, laser, and surgical treatment of NVG in the anti-VEGF era, with attention to the close collaboration between glaucoma specialists and retina specialists. Neovascular Glaucoma - Current Concepts in Diagnosis and Treatment will change the way ophthalmologists manage NVG, ensuring patients better outcomes. It is a must-have resource for ophthalmologists worldwide.

::Contents##<br/>Section 1. Foreword. Water flux and amniotic fluid volume: understanding fetal water flow<br/>Body composition of fetus and newborn<br/>Potassium metabolism<br/>Section B. Renal aspects of sodium metabolism in the fetus and neonate<br/>Perinatal calcium and phosphorus metabolism<br/>Acid-base homeostasis in the fetus<br/>Section C. Glomerular filtration rate in neonates<br/>Section D. Renal development and molecular pathogenesis of renal dysplasia<br/>The developing kidney and the fetal origins of adult cardiovascular disease<br/>Fluid and electrolyte management of high risk infants<br/>Renal modulation: the renin-angiotensin-aldosterone system<br/>Renal modulation: arginine vasopressin and atrial natriuretic peptide<br/>Acute problems of prematurity: balancing fluid volume and electrolyte replacements in very low birth weight and extremely low birth weight neonates<br/>Lung fluid balance in developing lungs and its role in neonatal transition - Use of diuretics in the newborn<br/>Neonatal hypertension: diagnosis and management<br/>Edema<br/>Kidney injury in the neonate<br/>Hereditary tubulopathies<br/>Inherited disorders of calcium, phosphate and magnesium.

::Summary## "Kidney disease is frequently described as a public health problem. This book will unpack what we mean by "public health" and by "taking a public health approach." We will consider the global burden of kidney diseases and their determinants, with a focus on chronic kidney disease"-- Provided by publisher.

::Contents##<br/>Part I. Patient assessment. History and physical diagnosis<br/>Urinalysis<br/>Measurement of GFR<br/>Imaging techniques<br/>Renal biopsy<br/>Part II. Acute kidney injury. Epidemiology, etiology, pathophysiology and diagnosis<br/>Management options: CRRT<br/>Hepatorenal syndrome<br/>Cardiorenal syndrome<br/>Medications<br/>Sepsis<br/>Rhabdomyolysis<br/>Tumor lysis syndrome<br/>Contrast-induced nephropathy<br/>Acute glomerulonephritis and RPGN<br/>Nephrotic syndrome<br/>Obstructive uropathy<br/>Nephrolithiasis<br/>Part III. Chronic kidney disease. Epidemiology, etiology, pathophysiology and staging<br/>Anemia in chronic kidney disease<br/>Renal osteodystrophy<br/>Cardiovascular disease<br/>Hyperlipidemia<br/>Nutrition<br/>Management of the patient with progressive renal failure<br/>Drug dosing in patients with CKD<br/>Part IV. Primary glomerular disorders. Minimal change disease<br/>Focal segmental glomerulosclerosis<br/>Membranous nephropathy<br/>IgA nephropathy and Henoch Schonlein disease<br/>Membranoproliferative glomerulonephritis<br/>Part V. Secondary glomerular disorders. Diabetic nephropathy<br/>Lupus nephritis<br/>Dysproteinemias or light chain diseases<br/>Vascultides<br/>Thrombotic microangiopathies<br/>Part VI. Infection associated glomeruleonephritides. Post-infectious glomereulonephritis<br/>Viral hepatitis-associated glomerulonephritis<br/>HIV-associated renal disorders<br/>Part VII. Other renal parenchymal diseases. Fabry disease<br/>Cystic diseases of the kidneys<br/>Other hereditary renal disorders<br/>Tubulointerstitial diseases<br/>Urinary tract infections<br/>Renal neoplasias<br/>Part VIII. Renal diseases in special populations. Renal disease and hypertension in pregnancy<br/>Sickle cell nephropathy<br/>Renal disease in the elderly<br/>Part IX. Treatment options. Hemodialysis<br/>Home dialysis<br/>Peritoneal dialysis<br/>Therapeutic plasma exchange (plasmapheresis)<br/>Part X. Transplantation. Epidemiology and outcomes<br/>Donor and recipient evaluation<br/>Immunosuppression<br/>Rejection of the renal transplant<br/>Post-transplant malignancies<br/>Post-transplant infections<br/>Primary care of the renal transplant patient<br/>Part XI. Hypertension. Primary hypertension<br/>Renal parenchymal hypertension<br/>Renovascular disease<br/>Endocrine hypertension<br/>Other forms of secondary hypertension<br/>Renal diseases in African-Americans<br/>Resistant hypertension<br/>Hypertensive emergencies<br/>Pharmacologic treatment of hypertension<br/>Non-pharmacologic treatment of hypertension<br/>Part XII. Acid-base and electrolyte disorders. Volume disorders<br/>Genetic disorders of Na transport<br/>Hyponatremia and hypernatremia<br/>Hypokalemia and hyperkalemia<br/>Hypocalcemia and hypercalcemia<br/>Disorders of phosphorus metabolism<br/>Disorders of magnesium metabolism<br/>Metabolic acidosis<br/>Metabolic alkalosis<br/>Part XIII. Onconephrology.<br/>Part XIV. Palliative care nephrology.<br/>Part XV. Nephrology beginnings.<br/>Part XVI. Nephrology trivia.

::Summary## This book presents contributions from leading international experts in the field of nephrology. Each chapter is independent and discusses nephrology in the authors country, including the history of nephrology development, kidney disease epidemiology, clinical nephrology, dialysis practice in acute and chronic renal failure settings (hemodialysis, hemodiafiltration, peritoneal dialysis), pediatric nephrology, and kidney transplantation. In addition, the book covers topics such as the job market for nephrologists, reimbursement, nephrology education, and the number of professionals in the private and public sectors. With 53 chapters and more than 300 authors from all continents offering a unique perspective on nephrology practice, it provides a much-needed information source for nephrologists around the globe. The reader will be able to travel through Nephrology Worldwide, a pleasant reading experience with not only relevant information and updated data, but also a comprehensive look at the history, countries peculiarities, and a critical analysis of the scenario of nephrology and renal replacement therapy. A valuable resource for healthcare professionals and other stakeholders interested in learning about the status quo of Nephrology Worldwide. Both the failings and the successes are outlined in a way that should make this book a compelling read, not just for the well-informed renal physician, but also for planners and policy makers whose thinking and actions are integral to the way we practice medicine. Sir Peter J. Ratcliffe, Nephrologist and 2019 Nobel Prize Winner.<br/>::Contents##<br/>Nephrology Worldwide: the Vision, the Project, and the Mission<br/>Nephrology Worldwide: a Perspective from the International Society of Nephrology<br/>Nephrology in the Democratic Republic of the Congo<br/>Nephrology in Ethiopia<br/>Nephrology in Nigeria<br/>Nephrology in South Africa<br/>Nephrology in Uganda<br/>Nephrology in Canada<br/>Nephrology in Mexico<br/>Nephrology in the United States of America<br/>Nephrology in Cuba<br/>Nephrology in Argentina<br/>Nephrology in Bolivia<br/>Nephrology in Brazil<br/>Nephrology in Chile<br/>Nephrology in Uruguay<br/>Nephrology in Venezuela<br/>Nephrology in Bangladesh<br/>Nephrology in India<br/>Nephrology in Pakistan<br/>Nephrology in China<br/>Nephrology in Japan<br/>Nephrology in Cambodia<br/>Nephrology in Indonesia<br/>Nephrology in Malaysia<br/>Nephrology in Singapore<br/>Nephrology in Thailand<br/>Nephrology in Iran<br/>Nephrology in Israel<br/>Nephrology in the Sultanate of Oman<br/>Nephrology in Saudi Arabia<br/>Nephrology in Turkey<br/>Nephrology in United Arab Emirates<br/>Nephrology in Albania<br/>Nephrology in Bulgaria<br/>Nephrology in Croatia<br/>Nephrology in the Czech Republic<br/>Nephrology in Poland<br/>Nephrology in Russia<br/>Nephrology in Ukraine<br/>Nephrology in Denmark<br/>Nephrology in France<br/>Nephrology in Greece<br/>Nephrology in Italy<br/>Nephrology in Ireland<br/>Nephrology in the Netherlands<br/>Nephrology in Portugal<br/>Nephrology in the United Kingdom<br/>Nephrology in Spain<br/>Nephrology in Sweden<br/>Nephrology in Switzerland<br/>Nephrology in Australia<br/>Nephrology in New Zealand.

::Summary## This book provides physicians practicing at pain management clinics with comprehensive explanations of interventional therapeutic procedures including nerve blockade, as well as pharmacotherapy. Interventional therapeutic procedures including nerve blockade are categorized by devices into landmark ("blind"), X-ray-guided, ultrasound-guided, CT-guided, MR-guided, and endoscopic techniques. In this book, each chapter introduces one type of nerve blockade procedure that involves several different devices. The authors describe the pros and cons of each technique and make recommendations for the best devices to use. This book will also help anesthesiologists and other physicians to improve their treatment techniques.

::Summary## This book addresses the severe knowledge deficit in peripheral nerve amongst neurosurgeons, however this topic represents an integral part of the oral board examination. The book employs a case based approach with the highest-yield scenarios for oral boards, primarily focusing on nerve entrapments, trauma and tumors. Thanks to its question and answer format, the reader is encouraged to think about the cases and questions as if taking the real exam before they check the answers. The work also includes common pitfalls, a section on nerve examinations including video recordings, and a section on important clinical findings that should be diagnosed from the picture. The book not only serves neurosurgeons, but also plastic surgeons, orthopedists, and neurologists.<br/>::Contents##<br/>Front Matter<br/>Nerve Cases<br/>Front Matter<br/>Case I: Hand Weakness 1<br/>Case II: Shoulder Weakness 1<br/>Case III: Foot Drop 1<br/>Case IV: Foot Drop 2<br/>Case V: Tumor 1<br/>Case VI: Shoulder Pain<br/>Case VII: Tumor 2<br/>Case VIII: Trauma 1<br/>Case IX: Trauma 2<br/>Case X: Hand Pain<br/>Case XI: Shoulder Weakness 2<br/>Case XII: Tumor 3<br/>Case XIII: Thigh Pain 1<br/>Case XIV: Hand Weakness 2<br/>Case XV: Hand Weakness 3<br/>Case XVI: Arm Pain<br/>Case XVII: Hand Weakness 4<br/>Case XVIII: Thigh Pain 2<br/>Case IX: Trauma 3<br/>Case XX: Foot Pain<br/>Case XXI: Forearm Pain<br/>Case XXII: Thigh Weakness<br/>Examination<br/>Front Matter<br/>Examination of the Upper Limb<br/>Examination of the Lower Limb<br/>Instant Pattern Recognition<br/>Front Matter<br/>Sight Diagnosis<br/>Back Matter.

::Summary## Representing the treatment and management philosophy of Dr. Susan Mackinnon, Nerve Surgery provides extensive coverage of innovative surgical options as well as guidance on the management of complicated compression neuropathies. In addition to detailed information on tried-and-true as well as cutting-edge surgical techniques, it contains chapters on the basic principles of nerve surgery, such as Anatomy and Physiology for the Peripheral Nerve Surgeon and Evaluation of the Patient with Nerve Injury or Nerve Compression. Key Features: More than 850 compelling full-color figures and photographs demonstrate key concepts, Videos narrated by Dr. Mackinnon are available online, Coverage of important conditions that can be treated non-operatively, such as neurogenic thoracic outlet syndrome and multilevel compression neuropathy, Strategies and secondary procedures for failed nerve surgeries, Dr. Mackinnon provides tips on how she manages complicated pain problems. This book is a core reference for all plastic surgeons, neurosurgeons, orthopedic surgeons, hand surgeons, residents, and allied health specialists treating patients with nerve injuries.<br/>::Contents##<br/>Chapter 1: Anatomy and Physiology for the Peripheral Nerve Surgeon<br/>Chapter 2: Evaluation of the Patient with Nerve Injury or Nerve Compression<br/>Chapter 3: The Electrodiagnostic Examination with Peripheral Nerve Injuries<br/>Chapter 4: Nerve Repair and Grafting<br/>Chapter 5: Nerve Transfer for the Forearm and Hand<br/>Chapter 6: Nerve Transfer Procedures for Tetraplegia<br/>Chapter 7: Nerve Autograft Substitutes: Conduits and Processed Allografts<br/>Chapter 8: Peripheral Nerve Allotransplantation<br/>Chapter 9: Median Nerve Entrapment and Injury<br/>Chapter 10: Ulnar Nerve Entrapment and Injury<br/>Chapter 11: Radial Nerve Entrapment and Injury<br/>Chapter 12: Thoracic Outlet Syndrome<br/>Chapter 13: Injury and Compression Neuropathy in the Lower Extremity<br/>Chapter 14: Brachial Plexus Injuries<br/>Chapter 15: Obstetrical Brachial Plexus Palsy<br/>Chapter 16: Facial Nerve Injury<br/>Chapter 17: Tendon Transfers for Functional Reconstruction<br/>Chapter 18: Tumors of the Peripheral Nervous System<br/>Chapter 19: Surgical Management of Chronic Headaches, Migraines, and Neuralgias<br/>Chapter 20: Painful Sequelae of Peripheral Nerve Injuries.

::Summary## Site is designed to teach human anatomy to students of the health professions, and to serve to review anatomy for clinical rotations and USMLE preparation.

::Summary## Site is designed to teach human anatomy to students of the health professions, and to serve to review anatomy for clinical rotations and USMLE preparation.

::Contents##<br/>Introduction<br/>Head and neck<br/>Back<br/>Thorax<br/>Abdomen<br/>Pelvis<br/>Upper limb<br/>Lower limb<br/>Plate pearls<br/>Study guides.

::Contents##<br/>Section 1. Shoulder<br/>Section 2. Upper arm and elbow<br/>Section 3. Forearm and wrist<br/>Section 4. Hand and finger.

::Contents##<br/>Section 1: Spine<br/>Section 2: Pelvis, Hip, and Thigh<br/>Section 3: Knee<br/>Section 4: Lower Leg<br/>Section 5: Ankle and Foot.

::Contents##<br/>Section 1. Embryology<br/>section 2. Physiology<br/>section 3. Metabolic diseases<br/>section 4. Congenital and developmental disorders<br/>section 5. Rheumatic diseases<br/>section 6. Tumors of musculoskeletal system<br/>section 7. Injury to musculoskeletal system<br/>section 8. Soft tissue infections<br/>section 9. Complications of fracture.

::Contents##<br/>Section 1: Normal and Abnormal Development<br/>Section 2: Cerebral Cortex and Neurocognitive Disorders<br/>Section 3: Epilepsy<br/>Section 4: Psychiatry<br/>Section 5: Hypothalamus, Pituitary, Sleep, and Thalamus<br/>Section 6: Disorders of Consciousness (Coma)<br/>Section 7: Basal Ganglia and Movement Disorders<br/>Section 8: Cerebellum and Ataxia<br/>Section 9: Cerebrovascular Circulation and Stroke<br/>Section 10: Multiple Sclerosis and Other Central Nervous System Autoimmune Disorders<br/>Section 11: Infections of the Nervous System<br/>Section 12: Neuro-Oncology<br/>Section 13: Headache<br/>Section 14: Head Trauma.

::Contents##<br/>Section 1: Cranial Nerve and Neuro-Ophthalmologic Disorders<br/>Section 2: Spinal Cord: Anatomy and Myelopathies<br/>Section 3: Spinal Trauma<br/>Section 4: Nerve Roots and Plexus Disorders<br/>Section 5: Mononeuropathies<br/>Section 6: Peripheral Neuropathies<br/>Section 7: Autonomic Nervous System and Its Disorders<br/>Section 8: Pain<br/>Section 9: Floppy Infant<br/>Section 10: Motor Neuron and Its Disorders<br/>Section 11: Neuromuscular Junction and Its Disorders<br/>Section 12: Muscle and Its Disorders.

::Summary## View the cardiovascular system as only Netter images can depict it. This spectacularly illustrated volume, part of the masterwork known as the Netter (CIBA) "Green Books," provides a highly visual guide to the heart, from basic science, anatomy, and physiology to pathology and injury. This classic Netter reference has been updated to mirror the many exciting advances in cardiovascular medicine and imaging - offering unparalleled insights into anatomy, physiology, and clinical conditions. Gain a rich clinical view of all aspects of the cardiovascular system in one comprehensive volume, conveyed through beautiful illustrations and radiologic images. Clearly see the connection between basic science and clinical practice with an integrated overview of normal structure and function as it relates to pathologic conditions. Grasp current clinical concepts regarding development, pediatrics, and adult medicine captured in classic Netter illustrations, as well as new illustrations created by artist-physician Carlos Machado, MD, and others working in the Netter style. Quickly understand complex topics thanks to a concise text-atlas format that provides a context bridge between primary and specialized medicine. Benefit from matchless Netter illustrations that offer precision, clarity, detail and realism as they provide a visual approach to the clinical presentation and care of the patient.<br/>::Contents##<br/>Section 1: Anatomy<br/>Section 2: Physiology<br/>Section 3: Imaging<br/>Section 4: Embryology<br/>Section 5: Congenital Heart Disease<br/>Section 6: Acquired Heart Disease.

::Summary## "Perfect for residents, generalists, anesthesiologists, emergency department physicians, medical students, nurses, and other healthcare professionals who need a practical, working knowledge of cardiology, Netter's Cardiology, 3rd Edition, provides a concise overview of cardiovascular disease highlighted by unique, memorable Netter illustrations. This superb visual resource showcases the well-known work of Frank H. Netter, MD, and his successor, Carlos Machado, MD, a cardiologist who has created clear, full-color illustrations in the Netter tradition. New features and all-new chapters keep you up to date with the latest information in the field"--Publisher's description.<br/>::Contents##<br/>Section I: Introduction. Basic anatomy and embryology of the heart<br/>The history and physical examination<br/>Genetics in cardiovascular disease<br/>Effects of exercise on cardiovascular health<br/>Cardiovascular epidemiology and risk prediction models<br/>Stem cell therapies for cardiovascular disease<br/>Section II: Diagnostic testing. Electrocardiography<br/>Chest radiography<br/>Echocardiography<br/>Stress testing and nuclear imaging<br/>Cardiac computed tomography and magnetic resonance imaging<br/>Diagnostic coronary angiography<br/>Left and right heart catheterization<br/>Section III: Vascular biology and risk factors for coronary artery disease. Atherosclerosis and angiogenesis<br/>Hypertension<br/>Lipid abnormalities<br/>Diabetes and cardiovascular events<br/>Cardiovascular effects of air pollutants<br/>Section IV: Coronary heart disease. Stable coronary artery disease<br/>Non-ST-elevation myocardial infarction<br/>ST-elevation myocardial infarction<br/>Percutaneous coronary intervention<br/>Coronary artery bypass surgery<br/>Cardiogenic shock after myocardial infarction and percutaneous support devices<br/>Congenital coronary anomalies<br/>Coronary hemodynamics and FFR<br/>Section V: Myocardial diseases and cardiomyopathy. epidemiology of congestive heart failure- HFpEF and HFrEF. Management of acute heart failure<br/>Management of chronic heart failure<br/>Hypertrophic cardiomyopathy<br/>Restrictive cardiomyopathy<br/>Hereditary cardiomyopathies<br/>Myocarditis<br/>Cardiac transplantation and mechanical circulatory support devices<br/>Stress-induced cardiomyopathy<br/>Section VI: Cardiac rhythm abnormalities. Bradyarrhythmias<br/>Supraventricular tachycardia<br/>Atrial fibrillation- rate vs. Rhythm<br/>Atrial fibrillation- stroke prevention<br/>Atrial fibrillation- ablation techniques<br/>Ventricular tachycardia<br/>Sudden cardiac death<br/>Syncope<br/>Cardiac pacemakers and defibrillators<br/>Section VII: Valvular heart disease. Aortic valve disease<br/>Mitral valve disease<br/>Cardiovascular manifestations of rheumatic fever<br/>Tricuspid and pulmonic valve disease<br/>Infective endocarditis<br/>Surgical treatment of valvular heart disease<br/>Section VIII: Structural heart disease. Clinical presentation of adults with congenital heart disease<br/>Catheter-based therapies for adult congenital heart disease<br/>Surgical interventions for congenital heart disease<br/>Transcatheter aortic valve replacement<br/>Transcatheter mitral valve repair<br/>Section IX: Pericardial diseases. Pericardial disease: clinical features and treatment<br/>Pericardial disease: diagnosis and hemodynamics<br/>Section X: Peripheral vascular disease. Renovascular hypertension and renal denervation<br/>Interventional approaches for peripheral arterial disease<br/>Surgery for peripheral vascular diseases<br/>Carotid artery revascularization<br/>Diseases of the aorta<br/>Deep vein thrombosis and pulmonary embolism<br/>Section XI: Cardiac considerations in specific populations and systemic diseases. Cardiovascular disease in pregnancy<br/>Neuromuscular diseases and the heart<br/>Cardiovascular manifestations of endocrine diseases<br/>Connective tissue diseases and the heart<br/>Cardiac tumors and cardio-oncology<br/>Pulmonary hypertension<br/>HIV and the heart<br/>Sleep disorders and the cardiovascular system<br/>Cardiovascular disease in women<br/>Cardiovascular disease in the elderly.

::Summary## "Designed to make learning more interesting and clinically meaningful, Netter's Concise Radiologic Anatomy matches radiologic images--from MR and ultrasound to CT and advanced imaging reconstructions--to the exquisite artwork of master medical illustrator Frank H. Netter, MD. As a companion to the bestselling Netter's Atlas of Human Anatomy, this updated medical textbook begins with the anatomy and matches radiologic images to the anatomic images; the result is a concise, visual guide that shows how advanced diagnostic imaging is an amazing "dissection tool" for viewing human anatomy in the living patient"--Publisher's description.<br/>::Contents##<br/>Head and neck<br/>Back and spinal cord<br/>Thorax<br/>Abdomen<br/>Pelvis and perineum<br/>Upper limb<br/>Lower limb.

::Contents##<br/>Overview of brain<br/>Brain<br/>Thalamus and basal ganglia<br/>Limbic system<br/>Brainstem and cranial nerves<br/>Ventricles and cerebrospinal fluid cisterns<br/>Sella turcica<br/>Overview of head and neck<br/>Paranasal sinuses<br/>Orbits<br/>Mandible, muscles of mastication<br/>Temporal bone (middle ear, cochlea, vestibular system)<br/>Oral cavity, pharynx, and suprahyoid neck<br/>Hypopharynx, larynx, and infrahyoid neck<br/>Overview of spine<br/>Spine.

::Contents##<br/>The cell<br/>Epithelium and exocrine glands<br/>Connective tissue<br/>Muscle tissue<br/>Nervous tissue<br/>Cartilage and bone<br/>Blood and bone marrow<br/>Cardiovascular system<br/>Lymphoid system<br/>Endocrine system<br/>Integumentary system<br/>Upper digestive system<br/>Lower digestive system<br/>Liver, gallbladder, and exocrine pancreas<br/>Respiratory system<br/>Urinary system<br/>Male reproductive system<br/>Female reproductive system<br/>Eye and adnexa<br/>Special senses.

::Contents##<br/>Section I: Esophagus<br/>GERD<br/>Section II: Stomach and duodenum<br/>Section III: Abdominal wall<br/>Section IV: Small intestine<br/>Section V: Colon, rectum, and anus<br/>Section VI: Infectious and parasitic diseases of the alimentary tract<br/>Section VII: Pancreas<br/>Section VIII: Gallbladder and bile ducts<br/>Section IX: Liver<br/>Section X: Nutrition and gastrointestinal disease.

::Contents##<br/>Development of the head and neck<br/>Osteology<br/>Basic neuroanatomy and cranial nerves<br/>The neck<br/>Scalp and muscles of facial expression<br/>Parotid bed and gland<br/>Temporal and infratemporal fossae<br/>Muscles of mastication<br/>Temporomandibular joint<br/>Pterygopalatine fossa<br/>Nose and nasal cavity<br/>Paranasal sinuses<br/>Oral cavity<br/>Tongue<br/>Pharynx<br/>Larynx<br/>Cervical fascia<br/>Ear<br/>Eye and orbit<br/>Autonomics of the head and neck<br/>Intraoral injections<br/>Introduction to the upper limb, back, thorax, and abdomen.

::Summary## Provides clear representations of common human diseases and concentrates on pathologic anatomy. Each chapter relates the anatomical changes to the functional and clinical manifestations of over 150 diseases and their underlying causes and mechanisms.<br/>::Contents##<br/>1. General reaction patterns :<br/>Introduction. 2. Cardiovascular system :<br/>Introduction<br/>Congenital malformations<br/>Atherosclerosis<br/>Coronary heart disease<br/>Hypertensive cardiovascular disease<br/>Heart failure<br/>Diseases of the aorta<br/>Immunologic diseases<br/>Other inflammatory diseases of the heart<br/>Cardiomyopathies and metabolic diseases<br/>Valvular heart disease<br/>Tumors of the heart<br/>Diseases of the pericardium<br/>Trauma. 3. Respiratory system :<br/>Introduction<br/>Obstructive lung diseases<br/>Restrictive lung diseases<br/>Vascular lung diseases<br/>Pulmonary infectious diseases<br/>Tumors in the lungs and the pleura. 4. Gastrointestinal system :<br/>Introduction<br/>Diseases of the esophagus<br/>Diseases of the stomach<br/>Diseases of the small and large intestines<br/>Bowel obstruction<br/>Tumors of the small and large intestines. 5. Liver, gallbladder, and pancreas :<br/>Introduction<br/>Inflammatory diseases of the liver<br/>Toxic and immunologic disorders of the liver<br/>Metabolic diseases involving the liver<br/>Primary tumors of the liver<br/>Cholelithiasis and cholecystitis<br/>Tumors of the gallbladder and the bile ducts<br/>Acute and chronic pancreatitis<br/>Cystic fibrosis<br/>Carcinoma of the pancreas. 6. Kidneys, ureters, and urinary bladder :<br/>Introduction<br/>Primary diseases of the kidney<br/>The kidney and systemic diseases<br/>Diseases of the urinary system. 7. Diseases of the male reproductive system :<br/>Introduction<br/>Development of the genital tracts<br/>Diseases of the penis and the urethra<br/>Diseases of the prostate gland and the seminal tract<br/>Diseases of the scrotum and the testis. 8. Diseases of the female reproductive system :<br/>Introduction<br/>Diseases of the vulva<br/>Diseases of the vagina<br/>Diseases of the uterus<br/>Diseases of the fallopian tubes<br/>Diseases of the ovary<br/>Pregnancy and its diseases<br/>Pathology of the mammary gland. 9. Integumentary system (skin) :<br/>Introduction<br/>Acute dermatitis<br/>Chronic dermatitis<br/>Vesicular and bullous dermatoses<br/>Infectious diseases<br/>Hyperplasia and benign tumors<br/>Malignant tumors. 10. Hematopoietic and lymphatic tissues :<br/>Introduction<br/>Red blood cell disorders<br/>White blood cell disorders (Nonlymphatic)<br/>Nonneoplastic lymphatic disorders<br/>Neoplastic lymphatic disorders. 11. Bones, joints, and soft tissues :<br/>Introduction<br/>Diseases of calcium metabolism<br/>Infectious diseases<br/>Noninfectious arthritic diseases<br/>Paget disease<br/>Tumors of the skeletal system<br/>Soft tissue disorders. 12. Endocrine system :<br/>Introduction<br/>Hypothalamus<br/>Pituitary gland<br/>Thyroid gland<br/>Parathyroid glands<br/>Adrenal cortex<br/>Adrenal medulla<br/>Endocrine pancreas. 13. Nervous system :<br/>Introduction<br/>Neurologic disorders of infancy and childhood<br/>Pathologic basis of common problems in neurology<br/>Cerebrovascular disease<br/>Central nervous system trauma<br/>Brain tumors<br/>Degenerative disorders of the central nervous system<br/>Infectious diseases<br/>Demyelinating disorders of the central nervous system<br/>Disorders of the spinal cord, nerve root, and plexus<br/>Disorders of the motor neuron, peripheral nerve, neuromuscular junctioon, and skeletal muscles.

::Summary## This updated edition of Netter's Illustrated Pharmacology allows you to take a distinct visual approach to understanding both the basic science and clinical applications of pharmacology. Designed to be compatible and used in conjunction with other pharmacology resources, this medical reference book offers a vivid, uniquely effective visual presentation of the pharmacodynamic relationship between drugs and the human body. And with the new addition of Student Consult online access, Netter's Illustrated Pharmacology is even more convenient than ever before! Available online for the first time! Search the full contents of Netter's Illustrated Pharmacology no matter what your location with convenient access to Student Consult.Visually grasp the most important principles in pharmacology with succinct, easy-to-understand presentations of introductory pharmacologic principles based on classic images by Frank Netter, as well as dynamic new illustrations from other talented medical artists.Learn how drugs are used to treat specific disorders in the body, as well as their effects on a particular site, with a format divided by organ system and full-color illustrations of the systems themselves.Access in-depth guidance on the must-know elements of each pharmacologic principle with clear, concise notes located beneath the corresponding image.<br/>::Contents##<br/>Basic Principles of Pharmacology<br/>Drugs Used to Affect the Autonomic and Somatic Nervous Systems<br/>Drugs Used in Disorders of the Central Nervous System and Treatment of Pain<br/>Drugs Used in Disorders of the Cardiovascular System<br/>Drugs Used in Disorders of the Endocrine System<br/>Drugs Used in Disorders of the Gastrointestinal System<br/>Drugs Used in Disorders of the Respiratory System<br/>Drugs Used in Disorders of the Reproductive System<br/>Drugs Used to Affect Renal Function<br/>Drugs Used in Infectious Disease<br/>Drugs Used in Neoplastic Disorders<br/>Drugs Used for Skin Disorders<br/>Vitamins: Deficiencies and Drug Interactions<br/>Drug Allergy, Abuse, and Poisoning or Overdose.

::Contents##<br/>The team physician<br/>The certified athletic trainer and the athletic training room<br/>The preparticipation physical evaluation<br/>Sideline preparedness and emergencies<br/>Sports nutrition<br/>Sports supplements<br/>Sports pharmacology of pain and inflammation control in athletes<br/>Sports pharmacology of chronic disease<br/>Sports pharmacology of psychiatry and behavioral medicine<br/>The pediatric athlete<br/>The high school athlete : setting up a high school sports medicine program<br/>The female athlete<br/>The senior athlete<br/>The athlete with physical disability<br/>Care of athletes at different levels : from pee-wee to professional<br/>The wilderness athlete and adventurer<br/>Exercise prescription and physiology<br/>Aerobic training<br/>Resistance training<br/>Flexibility<br/>Exercise in the heat and heat illness<br/>Exercise in the cold and cold injuries<br/>Altitude training and competition<br/>Travel considerations for the athlete and sports medical team<br/>The role of sport psychology and sports psychiatry<br/>Drugs and doping in athletes<br/>Eating disorders in athletes<br/>Overtraining<br/>Infections in athletes<br/>Gastrointestinal problems<br/>Hematologic problems in the athlete<br/>Renal and genitourinary problems<br/>The athlete with diabetes<br/>ECG interpretation in athletes<br/>Cardiac disease in athletes<br/>The hypertensive athlete<br/>Exercise-induced bronchoconstriction, urticaria, and anaphylaxis<br/>Neurologic problems in the athlete<br/>Headache in the athlete<br/>Skin problems in the athlete<br/>Connective tissue diseases and rheumatologic problems in athletes<br/>Musculoskeletal injuries in sports<br/>Comprehensive rehabilitation of the athlete<br/>Physical modalities in sports medicine<br/>Head injuries<br/>Neck injuries<br/>Eye injuries<br/>Maxillofacial injuries<br/>Shoulder injuries<br/>Elbow injuries<br/>Hand and wrist injuries<br/>Thorax and abdominal injuries<br/>Thoracic and lumbosacral spine injuries<br/>Pelvis, hip, and thigh injuries<br/>Knee injuries<br/>Ankle and leg injuries<br/>Cartilage problems in sports<br/>Acute fractures and dislocations in athletes<br/>Stress fractures<br/>Foot problems<br/>Taping and bracing<br/>Injections in the athlete<br/>Diagnostic imaging in sports medicine<br/>Sports ultrasound<br/>Injury prevention protocols<br/>Football<br/>Soccer<br/>Rugby<br/>Lacrosse<br/>Field hockey<br/>Ultimate frisbee<br/>Basketball<br/>Volleyball<br/>Baseball<br/>Softball<br/>Tennis<br/>Alpine skiing<br/>Cross-country skiing<br/>Snowboarding<br/>Ice hockey<br/>Ice skating (figure skating and speed skating)<br/>Swimming and diving<br/>Scuba diving<br/>Sailing<br/>Rowing<br/>Martial arts<br/>Boxing<br/>Wrestling<br/>Mixed martial arts<br/>Gymnastics<br/>Cheerleading<br/>Dance<br/>Track and field<br/>Road biking<br/>Mountain biking<br/>Inline skating, skateboarding, and bicycle motocross<br/>Mass participation endurance events<br/>Ultraendurance and adventure racing and events<br/>Rock climbing<br/>Rodeo and equestrian sports<br/>The extreme athlete<br/>Esports.

::Summary## "Netter's Surgical Anatomy and Approaches, 2nd Edition, provides a clear overview of the exposures, incision sites, surgically relevant landmarks, structures, fascial planes, and common anatomical variants relevant to general surgical operative procedures. Whether used in class, in the lab while learning anatomy, or in the operating room as a trusted reference, this highly visual resource presents unmatched surgical anatomy illustrations by world-renowned surgeon-artist, Frank H. Netter, MD, and new illustrations created in the Netter tradition, as well as surgical exposures, intraoperative photographs, and radiologic imaging"--Publisher's description.<br/>::Contents##<br/>Selective (supraomohyoid) neck dissection, levels I-III<br/>Tracheostomy<br/>Thyroidectomy and parathyroidectomy<br/>Laparoscopic adrenalectomy<br/>Esophagectomy<br/>Minimally invasive antireflux surgery<br/>Truncal and selective vagotomy<br/>Gastrectomy<br/>Gastric emptying procedures<br/>Roux-en-y gastric bypass and sleeve gastrectomy<br/>Surgical management of achalasia<br/>Cholecystectomy<br/>Common bile duct surgery and choledochoduodenostomy<br/>Hepatectomy<br/>Distal pancreatectomy<br/>Pancreatoduodenectomy<br/>Splenectomy<br/>Liver transplantation<br/>Living donor liver transplantation<br/>Intestinal and multivisceral transplantation<br/>Kidney transplantation<br/>Pancreas and kidney transplantation<br/>Laparoscopic donor nephrectomy<br/>Deceased donor organ recovery<br/>Appendectomy<br/>Abdominal wall marking and stoma site selection<br/>Right colectomy<br/>Left and sigmoid colectomy<br/>Transverse colectomy<br/>Low anterior resection with total mesorectal excision and anastomosis<br/>Abdominoperineal resection<br/>Hemorrhoids and hemorrhoidectomy<br/>Perianal abscess and fistula in ano<br/>Suture rectopexy and ventral mesh rectopexy<br/>Ileal pouch anal anastomosis<br/>Sphincter repair and sacral neuromodulation<br/>Laparoscopic inguinal hernia repair<br/>Surgical approach to chronic groin pain following inguinal hernia repairs<br/>Open flank and lumbar hernia repair<br/>Open retromuscular hernia repair<br/>Carotid endarterectomy<br/>Carotid subclavian bypass/transposition and vertebral transposition<br/>Aortic aneurysm repair and thoracoabdominal aneurysm repair<br/>Visceral bypass<br/>Radiocephalic, brachiocephalic, and brachiobasilic fistula<br/>Femoral endarterectomy and femoral popliteal bypass<br/>Femoral tibial bypass<br/>Above-knee and below-knee amputation<br/>Tracheal intubation and endoscopic anatomy<br/>Chest tube placement<br/>Emergency thoracotomy for trauma<br/>Central line anatomy<br/>Arterial line anatomy<br/>Upper and lower extremity fasciotomy<br/>Mastectomy : partial and total<br/>Breast reconstruction<br/>Central duct excision and nipple discharge<br/>Sentinel lymph node biopsy<br/>Axillary lymphadenectomy and lymphaticovenous bypass<br/>Inguinal and pelvic lymphadenectomy<br/>Retroperitoneal sarcoma<br/>Hysterectomy for benign and malignant conditions<br/>Oophorectomy for benign and malignant conditions<br/>Reconstructive surgery for pelvic floor disorders<br/>Laparoscopic transperitoneal radical nephrectomy<br/>Radical prostatectomy<br/>Radical cystectomy<br/>Retroperitoneal lymph node dissection.

::Summary## Network Functions and Plasticity: Perspectives from Studying Neuronal Electrical Coupling in Microcircuits focuses on the specific roles of electrical coupling in tractable, well-defined circuits, highlighting current research that offers novel insights for electrical coupling's roles in sensory and motor functions, neural computations, decision-making, regulation of network activity, circuit development, and learning and memory. Bringing together a diverse group of international experts and their contributions using a variety of approaches to study different invertebrate and vertebrate model systems with a focus on the role of electrical coupling/gap junctions in microcircuits, this book presents a timely contribution for students and researchers alike.<br/>::Contents##<br/>Electrical coupling in Caenorhabditis elegans mechanosensory circuits / I. Rabinowitch, W.R. Schafer<br/>Neural circuits underlying escape behavior in Drosophila : focus on electrical signaling / P. Phelan, J.P. Bacon, J.M. Blagburn<br/>Gap junctions underlying labile memory / M.-F.M. Shih, C.-L. Wu<br/>The role of electrical coupling in rhythm generation in small networks / F. Nadim, X. Li, M. Gray, J. Golowasch<br/>Network functions of electrical coupling present in multiple and specific sites in behavior-generating circuits / J. Jing, E.C. Cropper, K.R. Weiss<br/>Electrical synapses and learning : induced plasticity in motor rhythmogenesis / R. Nargeot, A. Bédécarrats<br/>Electrical synapses and neuroendocrine cell function / N.S. Magoski<br/>Electrical synapses in fishes : their relevance to synaptic transmission / A.E. Pereda, M.V.L. Bennett<br/>Dynamic properties of electrically coupled retinal networks / S. Trenholm, G.B. Awatramani<br/>Circadian and light-adaptive control of electrical synaptic plasticity in the vertebrate retina / C.P. Ribelayga, J. O'Brien<br/>Electrical coupling in the generation of vertebrate motor rhythms / W.-C. Li, J.C. Rekling<br/>Implications of electrical synapse plasticity in the inferior olive / J.P. Welsh, J. Turecek<br/>Gap junctions between pyramidal cells account for a variety of very fast network oscillations (>80 Hz) in cortical structures / R.D. Traub, M.A. Whittington, A. Draguhn<br/>Lineage-dependent electrical synapse formation in the mammalian neocortex / S. He, S.-H. Shi.

::Contents##<br/>1. Introduction to evidence synthesis<br/>2. The core model<br/>3. Model fit, model comparison and outlier detection<br/>4. Generalised linear models<br/>5. Network meta-analysis within cost-effectiveness analysis<br/>6. Adverse events and other sparse outcome data<br/>7. Checking for inconsistency<br/>8. Meta-regression for relative treatment effects<br/>9. Bias adjustment methods<br/>10. Network meta-analysis of survival outcomes<br/>11. Multiple outcomes<br/>12. Validity of network meta-analysis<br/>Solutions to exercises<br/>Appendices<br/>References<br/>Index.

::Summary## Biological systems are extremely complex and have emergent properties that cannot be explained or even predicted by studying their individual parts in isolation. The reductionist approach, although successful in the early days of molecular biology, underestimates this complexity. As the amount of available data grows, so it will become increasingly important to be able to analyse and integrate these large data sets. This book introduces novel approaches and solutions to the Big Data problem in biomedicine, and presents new techniques in the field of graph theory for handling and processing multi-type large data sets. By discussing cutting-edge problems and techniques, researchers from a wide range of fields will be able to gain insights for exploiting big heterogonous data in the life sciences through the concept of 'network of networks'.

::Contents##<br/>Section 1. Circuit development<br/>section 2. Cognitive development<br/>section 3. Diseases.

::Summary## This book summarizes the latest research findings in the neurocircuitry of innate behaviors, covering major topics such as innate fear, aggression, feeding, reward, social interaction, parental care, spatial navigation, and sleep-wake regulation. For decades, humans have been fascinated by wild animals instincts, like the annual two-thousand-mile migration of the monarch butterfly in North American, and the "imprint" behavior of newborn birds. Since these instincts are always displayed in stereotypical patterns in most individuals of a given species, the neural circuits processing such behaviors must be genetically hard-wired in the brain. Recently, with the development of modern techniques, including optogenetics, retrograde and anterograde virus tracing, and in vivo calcium imaging, researchers have been able to determine and dissect the specific neural circuits for many innate behaviors by selectively manipulating well-defined cell types in the brain. This book discusses recent advances in the investigation of the neural-circuit mechanisms underlying innate behaviors.<br/>::Contents##<br/>Intro<br/>Contents<br/>Contributors<br/>Chapter 1: Neural Circuits Underlying Innate Fear<br/>1.1 Introduction<br/>1.2 Animal Studies<br/>1.2.1 Retinal Ganglion Cells That Detect Looming Signals<br/>1.2.2 Brain Circuits That Mediate Looming-Evoked Fear Responses in Mice<br/>1.3 Human Studies<br/>References<br/>Chapter 2: Neurobiology and Neural Circuits of Aggression<br/>2.1 Introduction<br/>2.2 Experimental Paradigms to Explore Aggression in Rodents<br/>2.3 Neuroendocrinology of Aggression<br/>2.4 Neurotransmitter Systems in Aggression<br/>2.5 Neurocircuitry of Aggressive Behavior<br/>2.5.1 Amygdala 2.5.2 Hypothalamus<br/>2.5.3 Prefrontal Cortex<br/>2.5.4 Lateral Septum<br/>2.5.5 Other Brain Areas<br/>2.5.6 Synthesis<br/>2.6 Translational Implications<br/>References<br/>Chapter 3: Neural Regulation of Feeding Behavior<br/>3.1 Introduction<br/>3.2 Homeostatic Feeding<br/>3.2.1 Sensing Metabolic State<br/>3.2.2 Foraging and Hunting for Food<br/>3.2.3 Consuming Food<br/>3.2.4 Termination of Feeding<br/>3.3 Hedonic Feeding<br/>3.4 Conclusion<br/>References<br/>4: Neural Circuits for Reward<br/>4.1 Introduction<br/>4.2 Dopamine and Innate Behavior<br/>4.3 Medium Spiny Neurons in Striatum and Innate Behavior 4.4 Ventral Tegmental Area (VTA) Neurons and Innate Behavior<br/>4.5 Prefrontal Cortex and Innate Behavior<br/>4.6 Conclusion<br/>References<br/>Chapter 5: Neuronal Response and Behavioral Modulation in Social Interactions<br/>5.1 Neuronal Response in Social Behavior<br/>5.1.1 Neuronal Response in Social Interaction<br/>5.1.1.1 Medial Prefrontal Cortex<br/>5.1.1.2 Amygdala<br/>5.1.1.3 Ventral Tegmental Area<br/>5.1.2 Neuronal Response in Aggression<br/>5.1.2.1 Hypothalamus<br/>5.1.3 Neuronal Response in Dominance<br/>5.1.3.1 mPFC<br/>5.1.4 Neuronal Response in Social Defeat 5.1.5 Neuronal Response in Social Memory<br/>5.1.5.1 Hippocampus<br/>5.2 Neural Circuit Manipulation and Social Behavior<br/>5.2.1 Social Interaction<br/>5.2.1.1 mPFC<br/>5.2.1.2 VTA<br/>5.2.1.3 Amygdala<br/>5.2.2 Social Memory<br/>5.2.2.1 Hippocampus<br/>5.2.3 Dominance Behavior<br/>5.2.3.1 mPFC<br/>5.2.4 Aggression<br/>5.2.4.1 Hypothalamus<br/>References<br/>Chapter 6: Neural Circuit Mechanisms That Underlie Parental Care<br/>6.1 Introduction<br/>6.2 Factors That Influence the Display of Parental Behaviors<br/>6.2.1 Olfactory and Auditory Cues Emitted by Pups<br/>6.2.2 Environmental Stressors 6.2.3 Reproductive Status<br/>6.3 Brain Areas Involved in Parental Care<br/>6.3.1 Main Olfactory Epithelium and Vomeronasal Organ (MOE and VNO)<br/>6.3.2 Auditory Cortex<br/>6.3.3 Medial Amygdala (MeA)<br/>6.3.4 Medial Preoptic Area (mPOA)<br/>6.3.4.1 mPOA Galanin+ Neurons<br/>6.3.4.2 mPOA Esr1+ Neurons<br/>6.3.4.3 mPOA Vgat+ Neurons<br/>6.3.5 Ventral Tegmental Area (VTA)<br/>6.3.6 Periaqueductal Gray (PAG)<br/>6.3.7 Paraventricular Nucleus of the Hypothalamus (PVN)<br/>6.3.8 Medial Prefrontal Cortex (mPFC)<br/>6.3.9 Ventrolateral Division of the Ventromedial Hypothalamus (VMHvl)