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  • Book
    Dayong Wang.
    Summary: This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs' translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.

    Intro; Preface; Contents;
    Chapter 1: Values of C. elegans in Toxicological Study; 1.1 Introduction; 1.2 Raise of a Series of Useful Sublethal Endpoints for Toxicity Assessment of Environmental Toxicants; 1.3 High-Throughput Screen and Identification of Chemicals; 1.4 Toxicity Assessment of Environmental Toxicants Under Susceptible Genetic Backgrounds; 1.5 Toxicity Assessment of Environmental Toxicants at Environmentally Relevant Concentrations; 1.6 Understanding the In Vivo Physicochemical, Cellular, and Physiological Mechanisms of Toxicity Induced by Environmental Toxicants. 1.7 Elucidation of Toxicological Mechanisms of Environmental Toxicants in Certain Targeted Organs1.8 Elucidation of Underlying Molecular Mechanisms of Toxicity Induced by Environmental Toxicants; 1.9 Distribution and Translocation of Environmental Toxicants; 1.10 Confirmation of Chemical with Low-Toxicity or Non-Ưtoxicity Property; 1.11 Limitations of C. elegans in the Toxicological Study; References;
    Chapter 2: Endpoints for Toxicity Assessment of Nanomaterials; 2.1 Introduction; 2.2 Lethality; 2.3 Morphology and Development; 2.4 Reproduction. 2.4.1 Endpoints Assessing the Development of Reproductive Organs2.4.1.1 Germline Apoptosis; Number of Apoptotic Cells per Gonad Arm Using CED-1::GFP Transgenic Strain; Assay of DNA Damage Using HUS-1::GFP Transgenic Strain; Assay of 40,6-Diamidino-2-Phenylindole (DAPI) Staining; 2.4.2 Endpoints Assessing the Function of Reproductive Organs; Brood Size; The Number of Oocytes; Egg Ejection; Embryonic Lethality; 2.4.3 Reproduction of Male Nematodes; Male Formation Assay; Abnormal Male-Specific Structures. 2.5 Neuronal Development and Function2.5.1 Neuronal Development; Analysis of Axonal Degeneration and Neuronal Loss of D-Type GABAergic Motor Neurons; Fluorescent Images of Certain Neurons; 2.5.2 Neuronal Function; Movement Speed; Locomotion Behavior; Thermotaxis Perception and Thermotaxis Learning Assays; Foraging Behavior Assay; Shrinking Behavior Assay; Neurotransmission; 2.6 Intestinal Development and Function; 2.6.1 Intestinal Development. Analysis of Intestinal Development Based on Transmission Electron Microscopy (TEM) Assay2.6.1.2 Analysis of Expression Patterns of Genes Required for the Control of Intestinal Development; 2.6.2 Intestinal Function; Intestinal Reactive Oxygen Species (ROS) Production; Intestinal Permeability; 2.6.3 Defecation Behavior; Defecation Behavior; Analysis and Fluorescent Images of Neurons Controlling the Defecation Behavior; Analysis of Expression Patterns of Genes Required for the Control of Defecation Behavior; 2.7 Epidermal Development.
    Digital Access Springer 2018