BookMahendra Rai, editor.
Summary: The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.
Contents:
Intro
Preface
Contents
Contributors
Part I: Skin Infections
Chapter 1: Nitric Oxide-Releasing Nanomaterials and Skin Infections
1.1 Introduction
1.2 NO and Human Skin
1.3 Delivering NO to Human Skin
1.4 Nanoparticles for Dermatological Applications
1.4.1 Liposomes
1.4.2 Polymeric Nanoparticles
1.4.3 Metallic Nanoparticles
1.5 NO-Releasing Nanomaterials for Biomedical Purposes
1.5.1 NO-Releasing Nanoparticles in the Management of Skin Infection
1.5.1.1 Bacterial Infections
1.5.1.2 Fungal Infections
1.5.1.3 Parasitic Infections 1.6 Conclusions
References
Chapter 2: Metal Nanoparticle Based Antibacterial Nanocomposites for Skin Infections
2.1 Introduction
2.2 Anatomy and Physicochemical Properties of Skin
2.3 Type of Bacterial Infections in Skin
2.4 Emergence of Various Types of Metal Nanoparticles (MNPs) and Its Composites
2.5 Essences of New Class of Nanoscale Materials Suitable Against Skin Infections
2.6 Nanoscale Materials as Antibacterial Skincare Agents
2.6.1 Metal Nanoparticles
2.6.1.1 Silver Nanoparticles (Ag NPs)
2.6.1.2 Gold Nanoparticles (Au NPs)
2.6.2 Metal Oxide NPs 2.6.2.1 Titanium Dioxide Nanoparticles
2.6.2.2 Zinc Oxide Nanoparticles
2.6.2.3 Copper Oxide Nanoparticles
2.6.2.4 Other Metal Oxide Nanoparticles
2.6.3 Nanocomposites
2.7 Proposed Mathematical Models of Penetration of NPs Through Skin
2.8 Diffusion of NPs Through Skin
2.8.1 Mathematical Model for Diffusion Through Skin
2.8.2 Metal and Metal Oxide NPs Diffusion Through Skin
2.9 Conclusion
References
Chapter 3: Combination Therapy Using Metal Nanoparticles for Skin Infections
3.1 Introduction
3.2 Skin Infections
3.3 Types of Skin Infections 3.3.1 Bacterial Skin Infections
3.3.2 Fungal Skin Infections
3.3.2.1 Athlete's Foot or Tinea pedis
3.3.2.2 Jock Itch or Tinea cruris
3.3.2.3 Ringworm or Tinea corporis
3.3.2.4 Yeast Infections
3.3.3 Viral Skin Infections
3.3.3.1 Herpes Simplex Virus (HSV)
3.3.3.2 Chickenpox (Varicella zoster)
3.3.3.3 Shingle (Herpes zoster)
3.3.3.4 Molluscum Contagiosum
3.3.3.5 Measles and Rubella
3.3.3.6 Hand-Foot-and-Mouth Disease
3.3.3.7 Roseola
3.3.3.8 Warts
3.3.4 Parasitic Infections
3.4 Metal and Metal Oxide Nanoparticles on Skin Infections 3.4.1 Silver Nanoparticles (AgNPs)
3.4.2 Gold Nanoparticles (AuNPs)
3.4.3 Copper Nanoparticles (CuNPs)
3.4.4 Copper Oxide Nanoparticles (CuO NPs)
3.4.5 Titanium Oxide Nanoparticles (TiO2 NPs) and Zinc Oxide Nanoparticles (ZnO NPs)
3.5 Human Skin Penetration of Metallic Nanoparticles
3.6 Combined Therapy of Metallic Nanoparticles in Bacterial Skin Infections
3.7 Combined Therapy of Metallic Nanoparticles in Fungal Skin Infections
3.8 Combined Therapy of Metallic Nanoparticles in Viral Skin Infections