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  • Book
    edited by Alexan Mihai Grumezescu.
    Summary: Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized.

    Contents:
    1. Fabrication of polymeric core-shell nanostructures
    2. Emulsification-diffusion method to obtain polymeric nanoparticles: two decades of research
    3. Tools and Techniques for the optimized synthesis, reproducibility and scale up of desired nanostructures from plant derived material and their role in pharmaceutical properties
    4. Scale up of biopharmaceuticals production
    5. Physicochemical and morphological characterization of pharmaceutical nanocarriers and mathematical modelling of drug encapsulation/release mass transfer processes
    6. Biopharmaceutics and pharmacokinetics of multifunctional nanoparticles
    7. Technological delivery systems to improve biopharmaceutical properties
    8. From physicochemically stable nanocarriers to targeted drug delivery: in-vivo pharmacokinetic, pharmacodynamic and biodistribution studies
    9. Sterile dosage forms loaded nanosystems for parenteral, nasal, pulmonary and ocular administration
    10. Quantitative Characterization of Targeted Nanoparticulate Formulations for Prediction of Clinical Efficacy
    11. Analytical tools for reliable in vitro and in vivo performance testing of drug nanocrystals
    12. Application of one-step affinity purification of drug-binding proteins with practical magnetic nanoparticles to drug discovery
    13. Molecularly Imprinted Polymers as Separation Tools
    14. Detection of DNA damage induced by nanomaterials
    15. Pharmacological usage of an enzyme inhibitor - a selective inhibitor of 3-mercaptopyruvate sulfurtransferase reaction intermediate to control generation of polysulfide
    16. Regulatory Consideration in Nanotechnology Based Drug Products.
    Digital Access ScienceDirect 2018