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  • 2014 Springer
    Rajamannan, Nalini M.
    This book presents the cellular details and the basic molecular biology approaches for understanding cardiac valvular disease. It provides novel cellular targets for developing future clinical trials and comprehensive clinical discussion of this expanding field. Molecular Biology of Valvular Heart Disease will guide physicians on the potential medical therapies to treat valvular heart disease while providing a platform for cellular targeting of valvular heart disease. Residents and fellows in cardiology, interventional cardiology, cardiac surgery, and current and future valve biologists alike will find this book to be an invaluable resource for developing further interest and understanding of the cellular basis for cardiac valvular disease treatment.
  • 2012 ScienceDirect
    2012 ClinicalKey
    Carson, Sue; Miller, Heather B.; Witherow, D. Scott.
  • 2008 Springer Protocols
    Rapley, Ralph; Walker, John M.
    Also available: Print – 2008
  • 2013 Springer
    Allewell, Norma M.; Narhi, Linda O.; Rayment, Ivan.
    This volume of the series Biophysics for the Life Sciences focuses on the conceptual framework and major research tools of contemporary molecular biophysics. It is designed to enable non-specialists -both students and professionals in other fields - to understand how these approaches can be used across the biosciences and in medicine, agriculture, biotechnology, pharmaceutical development and other fields. The scope of this volume is appropriate for advanced undergraduate and graduate courses in biophysics and biophysical chemistry. The book begins with an overview of the development of molecular biophysics and a brief survey of structural, physical, and chemical principles. Subsequent chapters written by experts present, with examples, the major experimental methods: optical spectroscopy, X-ray and neutron diffraction and scattering, nuclear magnetic resonance, electron paramagnetic resonance, mass spectrometry, and single molecule methods. The relationship between the biophysical properties of biological macromolecules and their roles as molecular machines is emphasized throughout and illustrated with three examples DNA helicases, rotary motor ATPases, and myosin.The concluding chapter discusses future prospects in X-ray and neutron scattering, mass spectrometry, and pharmaceutical development.
  • 2001 ScienceDirect
    Komamine, Atsushi; Morohoshi, Noriyuki.
  • 2006 CRCnetBASE
    Landolph, Joseph R.; Warshawsky, David.
    Carcinogens and mutagens -- Whole animal carcinogenicity bioassays -- Molecular mechanisms of action of selected organic carcinogens -- Binding of carinogens to DNA and covalent adducts and DNA damage - PAH, aromatic amines, nitro-aromatic compounds, and halogenated compounds -- Cellular oncogenes and carcinogenesis -- Tumor suppressor genes -- Hepatitis B, Hepatitis C, and hepatocellular carcinoma -- Oncongenesis in transgenic and knockout mice -- Chemically induced morphological and neoplastic transformation in C3H/10T1/2 C1 8 mouse embryo cells -- Radiation carcinogenesis -- DNA microarrays and computational analysis of DNA microarray data in cancer research -- Application of proteomics in basic biological sciences and cancer -- Overview of human cancer induction and human exposure to carcinogens -- Complex mixtures of chemical carcinogens: principles of action and human cancer -- Lung cancer -- Breast cancer -- Cancer of the prostate - Mechanisms of molecular carcinogenesis -- Skin cancer: epidemiology, clinical manifestations, and genetic and molecular aspects -- Cell and molecular biology of cancer of the brain --Thyroid cancer: molecular biology and clinical aspects -- Chemoprevention of chemical carcinogenesis and human cancer -- Carcinogen biomarkers and exposure assessment -- Risk assessment for chemical carcinogens -- Prevention and regulation approaches to carcinogens.
    Also available: Print – 2006
  • 2005 Springer Protocols
    Sun, Zhongjie.
    Introduction to methods in molecular cardiology / Zhongjie Sun -- Gene therapy approaches to cardiovascular disease / J. Mark Jones and Walter J. Koch -- Gene therapy for myocardial ischemia using hypoxia inducible double plasmid / Yi Tang -- Cardiac gene delivery using dna-adenoviral constructs / J. Mark Jones and Walter J. Koch -- Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology / Yi-Fan Li ... [et al.] -- TAT-mediated protein transduction: delivering biologically active proteins into the heart / Asa B. Gustafson, Roberta A. Gottlieb, and David J. Granville -- Expression of human eNOS in cardiac and endothelial cells / Xiuqing Wang and Zhongjie Sun -- Strategies of conditional gene expression in myocardium: an overview / Heather Heine ... [et al.] -- Gene silencing method using adenoviral RNAi vector -- In cardiomyocytes and vascular smooth muscule cells / Hideko Kasahara and Hiroki Aoki -- Cardiac commitment of embryonic cells for myocardial repair / Dana Zeineddine ... [et al.] -- Autologous mesenchymal stem cells for post ischemic myocardial repair / Yao Liang Tang -- Cellular therapy with autologous skeletal myoblasts for ischemic heart disease and heart failure / Yao Liang Tang -- Protocols for myocardial infarction repair using fetal cardiac myocytes / Sharon Etzion ... [et al.] -- Methods for examining stem cells in post ischemic and transplanted hearts / Nana Rezai ... [et al.] -- Endothelial progenitor cell/ex vivo expansion and gene transfer / Hideki Iwaguro and Takayuki Asahara -- Delineation of sequences essential for specific promoter activation during pressure overloaded hypertrophy or factor-induced hypertrophy / Chellam Rajamanickam and Radhakrishnan Jeejabai -- Evaluation of cardiac isoform of 2 macroglobulin as a factor inducing cardiac hypertrophy / Chellam Rajamanickam and Radhakrishnan Jeejabai -- Detection of apoptosis in cardiovascular diseases / Arwen Hunter, Jonathan C. Choy, and David J. Granville -- Detection of cardiac signaling in the injured and hypertrophied heart / Xiaoning Si ... [et al.] -- Affymetrix oligonucleotide analysis of gene expression in the injured heart / Bobby Yanagawa ... [et al.] -- Identification and validation of loci and candidate genes -- Linked to cardiac hypertrophy / Bastien Llamas and Christian F. Deschepper -- Induction and analysis of cardiac hypertrophy in transgenic animal models / Marcos E. Barbosa, Natalia Alenina, and Michael Bader -- Methods for the detection of altered -adrenergic signaling pathways in hypertrophied hearts / Matthew J. Wolf, Hideo Takibana, and Howard A. Rockman -- Transgenic mouse models for cardiac dysfunction by a specific genetic manipulation / Gopal J. Babu and Muthu Periasamy -- Cardiomyocyte defects in diabetic models and protection with cardiac-targeted transgenes / Xia Shen ... [et al.] -- Protocols for cardiac-specific overexpression of angiotensin II type 1 receptor in transgenic rats / Sigrid Hoffmann.
    Also available: Print – 2005
  • 2013
    Lodish, Harvey F.
    Status: Not Checked OutLane Catalog Record
    Overview: Molecular Cell Biology presents the key concepts in cell biology and their experimental underpinnings. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. As always, a hallmark of MCB is the use of experiments to engage students in the history of cell biology and the research that has contributed to the field. The book contains predominantly color illustrations, with some black-and-white illustrations.
  • 2000 NCBI Bookshelf
    Lodish, Harvey F.
    Also available: Print – 2000
  • 2002 ScienceDirect
    Sansonetti, P. J.
    Also available: Print – 2002
  • ScienceDirect
    Baldwin, Thomas O.; Lorimer, George H.
    Also available: Print – 1998
  • 2006 Springer
    Gaestel, Matthias.
  • 2010
    Yeh, Yi-Chun; McAdams, Harley; Moerner, W. E.; Shapiro, Lucy.
    Cell division is a major developmental event in the life cycle of a bacterial cell. Caulobacter crescentus division is asymmetric, producing daughter cells that differ in morphology and polar features: a sessile stalked cell and a motile swarmer cell that subsequently differentiates into a stalked cell. In this work we investigate the assembly of the Caulobacter cell division machinery (the divisome) using genetics, biochemistry, and microscopy. In Caulobacter, the cell division process requires a set of approximately twenty-three proteins localizing from the cytoplasm to the outer membrane. To understand divisome assembly as a function of the cell cycle, we generated fluorescent fusions to analyze the temporal regulation of 19 representative divisome and division-site localized proteins. In Chapter 2, we identified a series of stages and transitions in divisome assembly and the associated events yielding a comprehensive temporal picture of the process. The assembly interdependency for divisome formation in Caulobacter appears to involve cooperative rather than sequential recruitment, suggesting that it is a multiprotein subcomplex model. In Chapter 3, we describe our investigation of the Tol-Pal complex where we demonstrated that it plays a vital role for membrane integrity maintenance and that it is essential for viability. Cryo-electron microscope images of the Caulobacter cell envelope exhibited outer membrane disruption, and cells failed to complete cell division in TolA, TolB, or Pal mutant strains. The Tol-Pal complex is required to maintain the position of the transmembrane TipN polar marker, and indirectly the PleC histidine kinase, at the cell pole, but it is not required for the polar maintenance of other transmembrane and membrane-associated polar proteins tested. Thus, the Caulobacter trans-envelope Tol-Pal complex is a key component of cell envelope structure and function, mediating outer membrane constriction at the final step of cell division, as well as the positioning of a protein localization factor. In Chapter 4, we describe our examination of the FtsZ binding protein, ZapA. FtsZ is the most highly conserved divisome protein that polymerizes into a contractile ring near midcell, defining the future site of cell division. We showed that ZapA is required to maintain a normal cell length, and promotes Z ring assembly. The biochemical and functional studies suggest that Caulobacter ZapA is a positive regulator of Z-ring assembly. In summary, we have addressed three major stages in developments of the divisome in Caulobacter: Z-ring assembly, divisome maturation and outer membrane invagination. These experiments have provided a new understanding of how the Caulobacter cell temporally executes the cell division program to propagate reliably and how Caulobacter cell division is performed.
  • 2010 Springer
    Luch, Andreas.
  • 2012 Springer
    Luch, Andreas.
    Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • 2009 Springer
    Luch, Andreas.
  • 2010
    Fan, Hei-Mun Christina; Altman, Russ B.; Covert, Markus; Quake, Stephen R.
    The concept of a personal genome stems from the fact that every human genome is unique. Measuring the unique features of a personal genome would help uncover the genetic basis of diseases and traits, and would be increasingly important in clinical diagnosis especially with the growing emphasis on personalized medicine. This thesis focuses on exploring the power of molecular counting to develop novel strategies that address the inadequacy of existing technologies in measuring the unique features of a human genome. The first focus of the thesis is aneuploidy detection, which has major application in prenatal diagnosis. While karyotyping of fetal cells is well-established for detecting aneuploidy, invasive sampling of fetal materials impose a small but significant risk to the health of both the mother and the fetus. A major research focus in the field of prenatal diagnosis has been to develop a noninvasive test for detecting fetal aneuploidy. Here, the concept of single molecule counting was applied to the problem of aneuploidy detection. The concept was first tested with digital PCR on invasively collected fetal materials, and subsequently extended to the noninvasive setting by shotgun sequencing maternal plasma DNA, which contains a small amount of fetal DNA. The former work led to the development of a polymorphism-independent method for rapid invasive diagnosis of aneuploidy, while the later work marked the development of the first polymorphism-independent method for the noninvasive diagnosis of fetal aneuploidy documented in the literature. The second focus of the thesis is molecular haplotyping. Present sequencing and other molecular techniques concentrate at identifying variants at isolated locations throughout a genome but largely ignore the haplotypes formed by these variants. Direct experimental determination of the haplotypes of an individual is challenging because of the lack of techniques to separate the two highly similar homologous copies of a chromosome. Here, a whole-genome haplotyping method was devised by analyzing amplified materials from single intact chromosomes within single cells, made possible by microfluidics. Such strategy enabled, for the first time, completely deterministic measurement of personal whole-genome haplotypes. It sets the stage for the direct sequencing of the two unique haploid genomes of any individual human, which has not been achieved by any personal genomes sequenced to date, and can potentially facilitate noninvasive fetal genome sequencing.
  • 2002 Springer Protocols
    Fan, Yao-Shan.
  • 2011 Springer
    Dhalla, Naranjan S.; Nagano, Makoto; Oštá̕dal, Bohuslav.
    Calcium Overloading-Induced Oxidative Stress-Mediated Cellular and Subcellular Remodeling -- Intracellular MMP-2: Role in Normal and Diseased Hearts -- Control of the Mesenchymal-Derived Cell Phenotype by Ski and Meox2: A Putative Mechanism for Postdevelopmental Phenoconversion -- Elevated Na+-H+ Exchanger Expression and Its Role in Myocardial Dise -- Impact of Perinatal Chronic Hypoxia on Cardiac Tolerance to Acute Ischemia -- Stem Cell, MicroRNA and Redox Cycling -- Cardiac Cell Therapy: Present and Future -- Macroscopic and Microscopic Aspects of Cardiac Dysfunction in Congestive Heart Failure -- Cardiac Dysfunction and Metabolism: Unravelling the Molecular Cross-Talk -- Metabolic Remodelling of the Hypertrophied Heart -- Mechanisms for the Regulation of Phospholipase C Gene Expression in Cardiac Hypertrophy -- Molecular Changes in Fatty Acid Oxidation in the Failing Heart -- Cardiolipin Metabolism in Experimental and Human Heart Failure -- Mechanisms Underlying Development of Cardiomyocyte Hypertrophy via Na-H Exchange Stimulation -- The Structural Basis of Cardiac Dysfunction in Human Heart Failure -- Hormonal Mechanisms of Cardiac Remodeling in Heart Failure -- Modulators of Remodeling After Myocardial Infarction -- Phosphodiesterase-5 Inhibitors in Protection Against Doxorubicin-Induced Cardiomyopathy -- Molecular Basis of Pulmonary Hypertension in Left Heart Failure -- Modulation of Gi Protein Expression in Hypertension: Molecular Mechanisms -- Vascular Dysfunction in Heart Disease -- Cellular and Molecular Mechanisms Associated with Salicylate Inhibition of Intimal Hyperplasia Following Balloon Catheter-Induced Vascular Injury -- Involvement of Growth Factor Receptor and Nonreceptor Protein Tyrosine Kinases in Endothelin-1 and Angiotensin II-Induced Signaling Pathways in the Cardiovascular System -- Sarco/Endoplasmic Reticulum Ca2+ Pump Damage by Oxidative Stress: Implications for Ca2+ Entry -- Obesity-Hypertension: Leptin as the Common Link to Cardiovascular and Renal Dysregulation -- Cardiorenal Protection in Diabetes Mellitus -- Molecular Mechanisms in the Pathogenesis of Diabetic Cardiomyopathy.
  • 2013 Springer Protocols
    Has, Cristina; Sitaru, Cassian.
    Molecular dermatology comes of age / Cristina Has and Cassian Sitaru -- Molecular diagnosis of autoimmune blistering diseases / Daisuke Tsuruta [and others] -- Molecular diagnosis of genodermatoses / Vesarat Wessagowit -- Three-dimensional visualization of the molecular architecture of cell-cell junctions in situ by cryo-electron tomography of vitreous sections / Ashraf Al-Amoudi and Achilleas S. Frangakis -- 3D visualization of epidermal Langerhans cells / Akiharu Kubo, Keisuke Nagao, and Masayuki Amagai -- In vivo imaging of lymph node lymphangiogenesis by immuno-positron emission tomography / Viviane Mumprecht and Michael Detmar -- Optical imaging of HPV infection in a murine model / Rhonda C. Kines [and others] -- Laser scanning microscopy approach for semiquantitation of in vitro dermal particle penetration / Hagar I. Labouta, Ulrich F. Schaefer, and Marc Schneider -- Analysis of cutaneous somatic mosaicism / Anna M.G. Pasmooij and Marcel F. Jonkman -- Global proteome analyses of SILAC-gabeled skin cells / Adrian Sprenger [and others] -- MicroRNA profiling during human keratinocyte differentiation using a quantitative real-time PCR method / Janosch Hildebrand [and others] -- Cell death in the skin : how to study its quality and quantity? / Roman Makarov [and others] -- In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus / Ken Ishii and Masayuki Amagai -- Induction of granulocyte-dependent dermal-epidermal separation by autoantibodies ex vivo / Mircea Teodor Chiriac -- Analysis of collective invasion of carcinoma cells in a 3D organotypic model / Jean Albrengues, Gerrino Meneguzzi, and Cedric Gaggioli -- Isolation of melanoma tumor-initiating cells from surgical tissues / Alexander D. Boiko -- Detection, enumeration, and characterization of immune cells infiltrating melanoma tumors / Benjamin Toh [and others] -- Analysis of cell movement between skin and other anatomical sites in vivo using photoconvertible fluorescent protein "Kaede"-transgenic mice / Michio Tomura and Kenji Kabashima -- Reconstitution of skin fibrosis development using a tissue engineering approach / Véronique J. Moulin -- Bioengineered skin humanized model of psoriasis / Marta Carretero, Sara Guerrero-Aspizua, and Marcela Del Río -- Induction of contact hypersensitivity in the mouse model / Stefan F. Martin --Generation of functional multipotent keratinocytes from mouse induced and pluripotent stem cells / Ganna Bilousova and Dennis R. Roop -- RNAi-mediated gene function analysis in skin / Slobodan Beronja and Elaine Fuchs -- Mouse models of autoimmune blistering diseases induced by the passive transfer of antibodies / Wataru Nishie -- induction of experimental epidermolysis bullosa acquisita by immunization with murine collagen VII / Alina Sesarman and Cassian Sitaru -- Animal model for cutaneous leishmaniasis / Michael R. Fischer [and others] -- Model for generation of large numbers of primary inflammatory skin-derived neutrophils and macrophages / Dominik John, Michael R. Fischer, and Esther von Stebut -- Zebrafish as a model system to study heritable skin diseases / Qiaoli Li and Jouni Uitto -- Cell- and protein-based therapy approaches for epidermolysis bullosa / Alexander Nyström, Leena Bruckner-Tuderman, and Johannes S. Kern -- RNA trans-splicing for genodermatoses / Johann W. Bauer [and others].
  • 2012
    Lesser, Adam; Du Bois, Justin; Kool, Eric T.; Wender, Paul A.
    The concepts of molecular analysis and design bring together structure, mechanism, and synthesis into a useful whole by allowing them to work toward a common goal. This thesis explores these concepts in two major subject areas: New Reactions and Protein/Ligand Interactions. In the first subject area, this work explores a major goal of organic synthesis, the realization of functional value of a molecular target via step economy. Indeed step economy dictates all other economies and costs including time, waste stream, and environmental goals. Improving known reactions is an important part of advancing synthesis. Of even greater consequence is the introduction of new reactions as they change how we think about bond construction. New reactions offer new ways to reduce step count and more effective and environmentally sound process options. This thesis work focuses on new reactions, new scaffolds, novel ligands for catalysis, and computational studies on these to advance this first subject area. In the second subject area, this work investigates protein/ligand interactions in the context of a cooperative project involving protein kinase C ligands. Molecular design and analysis have been fundamental in the development and implementation of this new project. This exciting area of impactful research is expected to provide numerous opportunities for further exploration. In Chapter 1, cyclooctatetraenes (COTs) are introduced as a fascinating class of molecules with great potential utility as building blocks for synthesis, scaffolds for drug discovery, ligands for catalysis, components for molecular detection devices, and novel materials. After discussing the synthesis, properties and applications of COTs, a discussion on metal-bound COTs is presented. This discussion is followed by a comprehensive critical review of the literature involving 1,2,5,6-4 COT ligands in transition metal complexes. This chapter provides background and justification for the further studies on the synthesis and use of COTs explored in Chapters 2-4. Chapter 2 describes the development of the Ni(0)-catalyzed [2+2+2+2] cycloaddition from tethered diynes that has made possible the synthesis of functionalized COTs. The initial design and development work is addressed, including the impact of important reaction variables. This is followed by an exploration of the substrate scope, including the syntheses of highly substituted COTs from non-terminal diynes to give highly substituted COTs. Studies on the physical properties and structure of these molecules are also addressed in the form of NMR experiments and X-ray crystallographic studies. Lastly, an approach toward the COT-containing natural product caulerpin utilizing the methodology is presented. This chapter provides the foundation for the COTs utilized in Chapters 3 and 4. Chapter 3 explores the use of the method developed in Chapter 2 toward metal binding ligands. A rational analysis of the COT scaffold is presented, with an emphasis on the synthesis of C2-symmetric ligands for metals. This is followed by the discussion of the synthesis and evaluation of two different ligand families encompassing 4 ligands in total. Important structural aspects of these ligands are investigated including advanced NMR and crystallographic studies. These ligands represent the first examples of topologically chiral racemic COTs used to coordinate metals through appended functionality. Initial successes and modeling studies in this area of metal-ligand binding led to the inspiration for the COTs and strategy utilized in Chapter 4. Chapter 4 is focused on the development of novel dinaphthocyclooctatetraene (dnCOT) Rh catalysts, and the resulting [5+2] cycloaddition studies. Initial unsuccessful results with COTs from Chapter 2 prompted a detailed analysis of factors involved in COT-metal bonding, including the development of a theoretical method for the prediction of COT geometries. This design-related work in turn guided the efficient synthesis of the dnCOT ligand. In addition, an expedient route to diversified dnCOTs was developed via a common bromide intermediate. The further development of dnCOT as a ligand for Rh included extensive characterization of the ligand and resulting Rh complexes in the form of crystallographic and NMR studies. Following these studies, the use of the Rh/dnCOT complex as a catalyst is examined in the context of the [5+2] cycloaddition. It was found that this species is an excellent catalyst for the reaction featuring superior reactivity in several cases when compared with other catalysts. The behavior of this catalyst was also investigated with respect to regioselectivities. The use of the Rh/dnCOT complex has also been briefly explored as a catalyst for other reactions. Finally, Chapter 5 examines the design and early implementation of a collaborative project involving protein kinase C (PKC) C1b domain ligands and REDOR NMR techniques. An introduction to PKC, bryostatin and REDOR NMR is given, followed by the overall project strategy. The design of NMR-labeled analogs of bryostatin is discussed in detailed, including computational studies used to help guide synthetic efforts. Preliminary work on elucidating the structure of the PKC/bryostatin complex is discussed in the form of docking studies to be integrated with experimental NMR data. The successful synthesis of one of the key labeled analogs designed in the previous sections, labellog 8, is described. Lastly, future directions for this promising project are explored.
  • ScienceDirect
    Langone, John J.
    Also available: Print – 1991
  • ScienceDirect
    Langone, John J.
    Also available: Print – 1991
  • 2011 CRCnetBASE
    Liu, Dongyou.
    "As more original molecular protocols and subsequent modifications are described in the literature, it has become difficult for those not directly involved in the development of these protocols to know which are most appropriate to adopt for accurate identification of bacterial pathogens. Molecular Detection of Human Bacterial Pathogens addresses this issue, with international scientists in respective bacterial pathogen research and diagnosis providing expert summaries on current diagnostic approaches for major human bacterial pathogens. Each chapter consists of a brief review on the classification, epidemiology, clinical features, and diagnosis of an important pathogenic bacterial genus, an outline of clinical sample collection and preparation procedures, a selection of representative stepwise molecular protocols, and a discussion on further research requirements relating to improved diagnosis. This book represents a reliable and convenient reference on molecular detection and identification of major human bacterial pathogens; an indispensable tool for upcoming and experienced medical, veterinary, and industrial laboratory scientists engaged in bacterial characterization; and an essential textbook for undergraduate and graduate students in microbiology"--Provided by publisher.
  • 2011 CRCnetBASE
    Liu, Dongyou.
    Pt. 1. Ascomycota -- pt. 2. Bastidiomycota -- pt. 3. Entomohpthoromycotina and Muscoromyotina -- pt. 4. Microsporidia -- pt. 5. Oomycota, Chlorophyta, and Mesomycetozoea -- pt. 6. Panfungal and drug resistance detection.
  • 2013 CRCnetBASE
    Liu, Dongyou.
    "A book on the molecular detection of major human viral, bacterial, fungal, and parasitic pathogens, this text provides coverage of the organisms with an emphasis on the sample preparation and molecular detection procedures. Chapters consist of concise reviews of pathogens in respect to taxonomy, biology, epidemiology, and pathogenesis; a description of a clinical sample collection preparation procedures; a summary of molecular detection methods available; and a discussion on the challenges, limitations, and advantages for current methods. Written for practitioners and students, this textbook is a guide for future development of improved molecular methods for pathogens. Offers an in-depth review of state-of-the-art molecular detection and identification methods for human parasitic pathogens. Provides comprehensive coverage of important human parasitic pathogens. Provides an authoritative summary of biology, epidemiology, and pathogenesis of major human parasitic pathogens. Includes chapter entries written by experts in respective fields of human parasitic pathogen collection"--Provided by publisher.
  • 2014 Springer
    Burtness, Barbara; Golemis, Erica.
    Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor β (TGFβ); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive β-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.
  • 2011 Springer
    DeWeese, Theodore L.; Laiho, Marikki.
    H2AX in DNA Damage Response -- DNA Damage Signaling Downstream of ATM -- Checkpoint Control Following Radiation Exposure -- Chromatin Responses to DNA Damage -- Caenorhabditis elegans Radiation Responses -- Hypoxia and Modulation of Cellular Radiation Response -- Inhibitors of DNA Repair and Response to Ionising Radiation -- Gene Therapy and Radiation -- Molecular Targeted Drug Delivery Radiotherapy -- EGFR Signaling and Radiation -- Thermal Modulation of Radiation-Induced DNA Damage Responses -- Radiation-Induced Immune Modulation.
  • 2003 Wiley
    Balzani, Vincenzo; Credi, A.; Venturi, M.
    ch. 1. General concepts -- ch. 2. Fundamental principles of electron and energy transfer -- ch. 3. Wires and related systems -- ch. 4. Switching electron- and energy-transfer processes -- ch. 5. Light-harvesting antennae -- ch. 6. Photoinduced charge separation and solar energy conversion -- ch. 7. Bistable systems -- ch. 8. Multistate-multifunctional systems -- ch. 9. Logic gates -- ch. 10. Basic principles of molecular machines -- ch. 11. Spontaneous mechanical-like motions -- ch. 12. Movements related to opening, closing, and translocation functions -- ch. 13. Rotary movements -- ch. 14. Threading-dethreading movements -- ch. 15. Linear movements -- ch. 16. Motions in catenanes.
  • 2005 Springer
    Viljoen, Gerrit J.; Crowther, John R.; Nel, L. H.
  • 2014 Springer
    Highsmith, W. Edward.
    Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
  • 2006 Springer
    Coleman, William B.; Tsongalis, Gregory J.
    Pt. I. Introduction. An historical perspective on the clinical diagnostic laboratory / Robert E. Moore -- Pt. II. Basic molecular biology. An overview of nucleic acid chemistry, structure, and function: the foundations of molecular biology / William B. Coleman -- Extraction of nucleic acids / Paul N. Bogner and Anthony A. Killeen -- Nucleic acid blotting techniques: theory and practice / Terry Amiss and Sharon collins Presnell -- The polymerase chain reaction / William B. Coleman and Gregory J. Tsongalis -- Bioinformatics: computer-based approaches to genetic analysis / Sharon L. Ricketts -- Pt. III. Molecular diagnostic technologies. PCR-based methods for mutation detection / Ian M. Frayling, Emma Monk, and Rachel Butler -- Alternative methods for amplified nucleic acid testing / Deborah A. Payne and Laurie E. Sower -- Electrophoretic methods for mutation detection and DNA sequencing / W. Edward Highsmith, Jr. -- Single-nucleotide polymorphisms: testing DNA variation for disease association / Ulrich Broeckel and Martin J. Hessner -- Microarray approaches to gene expression analysis / David Neil Hayes and Matthew Meyerson -- Methods for analysis of DNA methylation / Alexander Dobrovic -- Pt. IV. Other clinical diagnostic technologies / Flow Cytometry / Joseph A. DiGiuseppe -- Medical cytogenetics / Martha B. Kaegle -- Fluorescence In situ hybridization: a major milestone in luminous cytogenetics / Suneel D. Mundle and Robert J. Koska -- Immunohistochemistry / John Hunt ... [et al.] -- Lser capture microdissection / C. Robert Bagnell, Jr. -- Pt. V. Quality assurance in the molecular diagnostics laboratory. Framework for quality assurance in molecular diagnostics / Marlene Sabbath-Solitare, Selwyn J. Baptist, and Teresita Cuyegkeng Redondo -- Verification of molecular assays / Brent L. Seaton -- Standards and standardization of molecular diagnostics / John P. Jakupciak and Catherine D. O'Connell -- Laboratory-developed tests in molecular diagnostics / Andrea Ferreira-Gonzalez and Carleton T. Garrett -- Pt. VI. Applications of molecular diagnostics for genetic diseases. An overview of molecular genetics / Elaine Weidenhammer and Gregory J. Tsongalis -- Genetic basis of neurologic neuromuscular diseases / Narasimhan Nagan ... [et al.] -- Molecular mechanisms of endocrine disorders / Amy Potter and John A. Phillips III -- Molecular pathogenesis of cardiovascular disease / Alan H.B. Wu -- Molecular diagnostics in coagulation / Enrique Ballesteros -- Cystic fibrosis / Eugene H. Lewis III ... [et al.] -- Prenatal genotyping for identification of identification of fetuses at risk for immune cytopenic disorders / Martin J. Hessner and Brian R. Curtis -- Personalized medicine / Karen McCullough -- Pt. VII. Applications of molecular diagnostics for human cancers. Molecular pathogenesis of human cancer / William B. Coleman and Gregory J. Tsongalis -- Application of molecular diagnostics to hereditary nonpolyposis colorectal cancer / Ian M. Frayling ... [et al.] -- Molecular genetic applications to the diagnosis of lymphoma / William N. Rezuke, Jr. and Gregory J. Tsongalis -- Molecular genetic abnormalities in acute and chronic leukemias / Pei Lin and L. Jeffrey Medeiros -- Pt. VIII. Applications of molecular diagnostics for infectious diseases. Molecular testing for Chlamydia trachomatis and Neisseria gonorrhoeae / Alexandra Valsamakis -- Human Papillomavirus / Theresa M. Voytek and Gregory J. Tsongalis -- Molecular diagnosis for HIV-1 / Angela M. Caliendo and Charles E. Hill -- Hepatitis C / D. Robert Dufour -- Cytomegalovirus / Angela M. Caliendo and Nell S. Lurain -- Pt. IX. Applications of molecular diagnostics for identity-based testing. HLA typing using molecular methods / John L. Schmitz -- Molecular analysis for forensic casework and parentage testing / Tracey Dawson Cruz -- Molecular assessment of bone marrow transplant engraftment / Jessica K. Booker -- Use of DNA-based identity testing for specimen identification / Andrew Ricci Jr. and Gregory J. Tsongalis -- Pt. X. Issues for the clinical molecular pathology laboratory. Genetic counseling considerations in molecular diagnosis / Myra I. Roche -- Ethical, social, and legal issues related to molecular genetic testing / Jennifer L. Herbst and Jon F. Merz.
  • 2010 ScienceDirect
    Grody, Wayne W.
    Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. This handbook provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting.
  • 2010 CRCnetBASE
    Jørgensen, Jan Trøst; Winther, Henrik.
    This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.The book is the first of its kind to cover relevant subjects around molecular cancer diagnostics when used as important drivers in personalized cancer medicine. The different chapters of the book are authored by key opinion leaders, each representing their specialized areas, which provide the reader with expertise knowledge in the field.
  • 2014 ClinicalKey
    Azmi, Asfar S.
    Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets.
  • 2014 Springer
    Hosler, Gregory A.; Murphy, Kathleen M.
    "This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers -- clinicians, pathologists, laboratorians, and other inquisitive minds -- independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing "excise and pray" approaches with personalized medicine."--Publisher's website.
  • 2014 Springer Protocols
    Marincola, Francesco M.; Thurin, Magdalena.
    Novel insights/translational implication from the emerging biology of melanoma / Antoni Ribas -- Emerging clinical issues in melanoma in the molecularly targeted era / Ryan J. Sullivan and Michael B. Atkins -- Integrating molecular biomarkers into current clinical management in melanoma / Ragini Kudchadkar, Geoffrey Gibney, and Vernon K. Sondak -- Advances in adjuvant therapy : potential for prognostic and predictive biomarkers / Diwakar Davar [and three others] -- Immunologic monitoring of cancer vaccine trials using the ELISPOT assay / Lisa H. Butterfield and Mary Jo Buffo -- Markers for anti-cytotoxic T-lymphocyte antigen 4 (CTLA- 4) therapy in melanoma / Michael A. Postow [and four others] -- Marker utility for combination therapy / Ester Simeone, Antonio M. Grimaldi, and Paolo A. Ascierto -- Assaying for BRAF V600E in tissue and blood in melanoma / David J. Panka, James W. Mier, and Ryan J. Sullivan -- Selecting patients for KIT inhibition in melanoma / Richard D. Carvajal, Omid Hamid, and Cristina R. Antonescu -- Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma / Roger S. Lo and Hubing Shi -- Current status of diagnostic and prognostic markers in melanoma / Danielle Levine and David E. Fisher -- Chromosomal copy number analysis in melanoma diagnostics / Jeffrey P. North, Swapna S. Vemula, and Boris C. Bastian -- Construction and analysis of multiparameter prognostic models for melanoma outcome / Bonnie E. Gould Rothberg and David L. Rimm -- Immunohistochemical diagnostic and prognostic markers for melanoma / Mehdi Nosrati and Mohammed Kashani-Sabet -- Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma / Xiaowei Xu [and four others] -- Tumor-infiltrating lymphocytes and their significance in melanoma prognosis / Tobias Schatton [and three others] -- Pathological staging of melanoma / David E. Elder -- Genotyping of human leukocyte antigen (HLA) ancestral haplotypes as prognostic marker in cancer using PCR analysis / Lisa Villabona [and three others] -- B7-H abnormalities in melanoma and clinical relevance / Barbara Seliger -- Melanoma susceptibility genes and risk assessment / Alexander Marzuka-Alcalá, Michele Jacobs Gabree, and Hensin Tsao -- Clinical, pathologic, and imaging features and biological markers of uveal melanoma / Alia B. Rashid and Hans E. Grossniklaus -- Prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile / J. William Harbour -- Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma / Arupa Ganguly, Jennifer Richards-Yutz, and Kathryn G. Ewens -- ERBB4 mutation analysis : emerging molecular target for melanoma treatment / Christopher Lau [and three others] -- Epigenetic markers of prognosis in melanoma / Luca Sigalotti [and four others] -- Isolation of melanoma cell subpopulations using negative selection / Ana Slipicevic [and three others] -- Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients / Eiji Kiyohara [and three others] -- Detection of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma / Yangyang Wang [and three others] -- Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma / Brian A. Boone and Michael T. Lotze -- The clinical use of PET/CT in the evaluation of melanoma / Khun Visith Keu and Andrei H. Iagaru -- Immune system functional pathway analysis using single cell network profiling (SCNP) : a novel tool in cancer immunotherapy / Alessandra Cesano and David Spellmeyer -- Quantitative and spatial image analysis of tumor and draining lymph nodes using immunohistochemistry and high-resolution multispectral imaging to prdict metastasis / Kim R.M. Blenman and Peter P. Lee -- COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing / Elena Castellanos-Rizaldos [and seven others] -- Isolation of circulating microRNAs from microvesicles found in human plasma / John F. Quackenbush [and seven others] -- Detection of circulating tumor cells by photoacoustic flowmetry / Ryan M. Weight and John A. Viator -- Statistical design and evaluation of biomarker studies / Kevin K. Dobbin -- Tissue resources for clinical use and marker studies in melanoma / Jonathan L. Curry [and five others].
  • 2011 Springer
    Murphy, Michael J.
    Springer eBooks.
  • 2010 ScienceDirect
    Ansorge, Wilhelm; Patrinos, George P.
    Chapter 1. Molecular Diagnostics: Past, Present, and Future / George P. Patrinos, Wilhelm J. Ansorge -- Chapter 2 . Allele-Specific Mutation Detection / Aglaia Athanassiadou, Eleana F. Stavrou, Adamandia Papachatzopoulou, George P. Patrinos -- Chapter 3. Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation / Chinh T. Bui, Emmanuelle Nicolas, Georgina Sallmann, Maria Chiotis, Andreana Lambrinakos, Kylee Rees, Ian Trounce, Richard G.H. Cotton, Lauryn Blakesley, Andrew K. Godwin, Anthony T. Yeung -- Chapter 4. Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis / Panayiotis G. Menounos, George P. Patrinos -- Chapter 5. Capillary Electrophoresis / Anja Bosserhoff, Claus Hellerbrand -- Chapter 6. Temperature and Denaturing Gradient Gel Electrophoresis / Hartmut Peters, Peter N. Robinson -- Chapter 7. Real-Time Polymerase Chain Reaction / Lut Overbergh, Anna-Paula Giulietti, Dirk Valckx, Chantal Mathieu -- Chapter 8 - Pyrosequencing / Sharon Marsh -- Chapter 9. Application of Padlock and Selector Probes in Molecular Medicine / Mats Nilsson, Chatarina Larsson, Johan Stenberg, Jenny Göransson, Ida Grundberg, Magnus Isaksson, Tim Conze, Sara Henriksson -- Chapter 10. Molecular Cytogenetics in Molecular Diagnostics / Holger Tönnies -- Chapter 11. Analysis of Human Splicing Defects Using Hybrid Minigenes / Franco Pagani, Francisco E. Baralle -- Chapter 12. Detection of Genomic Duplications and Deletions / Graham R. Taylor, Carol A. Delaney -- Chapter 13. Multiplex Ligation-Dependent Probe Amplification (MLPA) and Methylation-Specific (MS)-MLPA: Multiplex Detection of DNA/mRNA Copy Number and Methylation Changes / Eline M. Sepers, Jan P. Schouten -- Chapter 14. Molecular Techniques for DNA Methylation Studies / Jörg Tost, Ivo G. Gut -- Chapter 15. High-Resolution Melting Curve Analysis for Molecular Diagnostics / Jared S. Farrar, Gudrun H. Reed, Carl T. Wittwer -- Chapter 16. DNA Microarrays and Genetic Testing / Lars Dyrskjøt, Karina Dalsgaard-Sørensen, Marie Stampe-Ostenfeld, Karin Birkenkamp-Demtroder, Kasper Thorsen, Claus L. Andersen, Mogens Kruhøffer, Jens L. Jensen, Torben F. Ørntoft -- Chapter 17. Arrayed Primer Extension Microarrays for Molecular Diagnostics / Neeme Tonisson, Eneli Oitmaa, Kaarel Krjutskov, Janne Pullat, Ilona Lind, Merike Leego, Ants Kurg, Andres Metspalu -- Chapter 18. Application of Proteomics to Disease Diagnostics / Samir Hanash, Ji Qiu, Vitor Faca -- Chapter 19. RNA-Based Variant Detection: The Protein Truncation Test / Johan T. den Dunnen -- Chapter 20. Protein Diagnostics by Proximity Ligation: Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses / Karl-Johan Leuchowius, Ola Söderberg, Masood Kamali-Moghaddam, Malin Jarvius, Irene Weibrecht, Katerina Pardali, Ulf Landegren -- Chapter 21. Mass Spectrometry and its Applications to Functional Proteomics / Thomas Köcher, Giulio Superti-Furga -- Chapter 22. Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and Clinical Care / Minoli Perera, Federico Innocenti -- Chapter 23. Nutrigenomics: Integrating Genomic Approaches into Nutrition Research / Lynette R. Ferguson, Martin Philpott, Matthew P.G. Barnett -- Chapter 24. Novel Next-Generation DNA Sequencing Techniques for Ultra High-Throughput Applications in Bio-Medicine / Wilhelm J. Ansorge -- Chapter 25. Locus-Specific and National/Ethnic Mutation Databases: Emerging Tools for Molecular Diagnostics / George P. Patrinos -- Chapter 26. Molecular Diagnostic Applications in Forensic Science / Bruce Budowle, John V. Planz, Rowan Campbell, Arthur J. Eisenberg -- Chapter 27. Mass Disaster Victim Identification Assisted by DNA Typing / Daniel Corach -- Chapter 28. Detection of Highly Pathogenic Viral Agents: Implications for Therapeutics, Vaccines and Biodefense / Kylene Kehn-Hall, Sina Bavari -- Chapter 29. Identification of Genetically Modified Organisms / Farid E. Ahmed -- Chapter 30. Molecular Diagnostics and Comparative Genomics in Clinical Microbiology / Alex van Belkum -- Chapter 31. Genetic Monitoring of Laboratory Rodents / Jean-Louis Guénet, Fernando J. Benavides -- Chapter 32. Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified Cells / Stephanie Laufs, Luisa Schubert, Patrick Maier, W. Jens Zeller, Stefan Fruehauf -- Chapter 33. Preimplantation Genetic Diagnosis / Martine de Rycke, Karen Sermon -- Chapter 34. Automated DNA Hybridization and Detection / Bert Gold -- Chapter 35. The Use of Microelectronic-Based Techniques in Molecular Diagnostic Assays / Piotr Grodzinski, Michael Ward, Robin Liu, Kathryn Scott, Saul Surrey, Paolo Fortina -- Chapter 36. Human Gene Patents and Genetic Testing / Timothy Caulfield, Yann Joly -- Chapter 37. Genetic Counseling and Ethics in Molecular Diagnostics / Mary Petrou -- Chapter 38. Genetic Testing and Psychology / Andrea Farkas Patenaude -- Chapter 39. General Considerations Concerning Safety in Biomedical Research Laboratories / William E. Grizzle, Walter C. Bell, Jerry Fredenburgh -- Chapter 40. Quality Management in the Laboratory / David Burnett.
  • 2010 Springer
    Debnath, Mousumi; Bisen, Prakash S.; Prasad, Godavarthi B. K. S.
  • 2008 Springer Protocols
    Mason, Ivor; Sharpe, Paul T.
    The mouse as a developmental model / Paul T. Sharpe -- Culture of postimplantation mouse embryos / Paul Martin and David L. Cockroft -- Organ culture in the analysis of tissue interactions / Irma Thesleff and Carin Sahlberg -- Treatment of mice with retinoids in vivo and in vitro / Gillian M. Morriss-Kay -- Analysis of skeletal ontogenesis through differential staining of bone and cartilage / Michael J. Depew -- Cell grafting and labeling in postimplantation mouse embryos / Gabriel A. Quinlan ... [et al.] -- Production of transgenic rodents by the microinjection of cloned DNA into fertilized one-celled eggs / David Murphy -- Cre recombinase mediated alterations of the mouse genome using embryonic stem cells / Anna-Katerina Hadjantonakis, Melinda Pirity, and András Nagy -- Gene trapping in mouse embryonic stem cells / Jane Brennan and William C. Skarnes -- Application of lacZ transgenic mice to cell lineage studies / Catherine M. Watson ... [et al.] -- Transgenic RNA interference to investigate gene function in the mouse / Tilo Kunath -- Mouse primordial germ cells : isolation and in vitro culture / Patricia A. Labosky and Brigid L.M. Hogan -- Gene transfer to the rodent embryo by retroviral vectors / Marla B. Luskin -- The avian embryo : an overview / Ivor Mason -- Chick embryos : incubation and isolation / Ivor Mason -- New culture / Amata Hornbruch -- EC culture : a method to culture early chick embryos / Andrea Streit -- Grafting Henson's node / Claudio D. Stern -- Microsurgical manipulation of the notochord / Lúcia E. Alvares ... [et al.] -- Transplantation of avian neural tissue / Sarah Guthrie -- Grafting of apical ridge and polarizing region / Cheryl Tickle -- Tissue recombinations in collagen gels / Marysia Placzek -- Quail-chick chimeras / Marie-Aimée Teillet, Catherine Ziller, and Nicole M. Le Douarin -- Using fluorescent dyes for fate mapping, lineage analysis, and axon tracing in the chick embryo / Jonathan D.W. Clarke -- Gene transfer in avian embryos using replication-competent retroviruses / Cairine Logan and Philippa Francis-West -- Electroporation in avian embryos / Jun-ichi Funahashi and Harukazu Nakamura -- An overview of Xenopus development / Michael Jones and James C. Smith -- Mesoderm induction assays / C. Michael Jones and James C. Smith -- Experimental embryological methods for analysis of neural induction in the amphibian / Ray Keller, Ann Poznanski, and Tamira Elul -- A method for generating transgenic frog embryos / Shoko Ishibashi, Kristin L. Kroll, and Enrique Amaya -- Axolotl/newt / Malcolm Maden -- The zebrafish : an overview of its early development / Nigel Holder and Qiling Xu -- Small-scale marker-based screening for mutations in zebrafish development / Peter D. Currie, Thomas F. Schilling, and Philip W. ingham -- Microinjection and cell transplantation in zebrafish embryos / Qiling Xu, Derek Stemple, and Katherine Joubin -- Recent advances in meganuclease- and transposon-mediated transgenesis of medaka and zebrafish / Clemens Grabher and Joachim Wittbrodt -- Retinoids in nonmammalian embryos / Malcolm Maden -- Protochordates / Peter W.H. Holland and Hiroshi Wada -- Subtractive hybridization and construction of cDNA libraries / Bruce Blumberg and Juan Carlos Izpisúa Belmonte -- Differential display of eukaryotic mRNA / Antonio Tugores and Juan Carlos Izpisúa Belmonte -- Using DNA microarrays / Clare Pritchard, Peter Underhill, and Andy Greenfield -- Profiling gene transcription in the developing embryo : microarray analysis on gene chips / David Chambers and Andrew Lumsden -- RT-PCR on embryos using degenerate oligonucleotide primers / Anthony Graham -- Single-cell RT-PCR cDNA subtraction / Ebrahim Sakhinia ... [et al.] -- In-situ hybridization of rdioactive riboprobes to RNA in tissue sections / Radma Mahmood and Ivor Mason -- In-situ hybridization and immunohistochemistry in whole embryos / Carol Irving -- Wholemount in situ hybridization to Xenopus embryos / C. Michael Jones and James C. Smith -- Wholemount in situ hybridization to Amphioxus embryos / Peter W.H. Holland -- In-situ hybridization to sections (nonradioactive) / Maria Rex and Paul J. Scotting -- Immunohistochemistry using polyester wax / Andrew Kent -- Immunohistochemistry on whole embryos / Ivor Mason -- Whole embryo assays for programmed cell death / Anthony Graham -- Protein techniques : immunoprecipitation, in vitro kinase assays, and western blotting / Clive Dickson -- Microscopy and photmicrography techniques / Richard J.T. Wingate.
  • 2011
    Rothman, Nathaniel.
    Status: Not Checked OutLane Catalog Record
  • pt. [A]-B 1993-2005. ScienceDirect
    pt. B, 2005 ScienceDirect
    Roalson, Eric H.; Zimmer, Elizabeth A.
  • 2002 Wiley
    Valeur, Bernard.
    ch. 1. Introduction -- ch. 2. Absorption of UV-visible light -- ch. 3. Characteristics of fluorescence emission -- ch. 4. Effects of intermolecular photophysical processes on fluorescence emission -- ch. 5. Fluorescence polarization. Emission anisotropy -- ch. 6. Principles of steady-state and time-resolved fluorometric techniques -- ch. 7. Effect of polarity on fluorescence emission. Polarity probes -- ch. 8. Microviscosity, fluidity, molecular mobility. Estimation by means of fluorescent probes -- ch. 9. Resonance energy transfer and its applications -- ch. 10. Fluorescent molecular sensors of ions and molecules -- ch. 11. Advanced techniques in fluorescence spectroscopy.
  • 2006 Springer
    Terech, P.; Weiss, Richard G.
  • 2008 Springer
    Cheng, Liang; Zhang, David Y.
  • 2013 Springer
    Cheng, Liang; Eble, John N.; Zhang, David Y.
    Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
  • 2012 Springer
    Best, D. Hunter; Swensen, Jeffrey J.
    Molecular genetic testing in the genomic era / Charles J. Sailey and Ferrin C. Wheeler -- Array comparative genomic hybridization in cytogenetics and molecular genetics / S. Hussain Askree and Madhuri R. Hegde -- Pharmacogenomics : tailoring treatment based on genotype / Alan H.B. Wu -- Somatic alterations and targeted therapy / Allison M. Cushman-Vokoun -- Genome-wide association studies in disease risk calculation : the role of bioinformatics in patient care / Todd L. Edwards, Digna R. Velez Edwards, and Marylyn DeRiggi Ritchie -- Presymptomatic genetic testing : shifting the emphasis from reaction to prevention / Irene H. Hung and John C. Carey -- Prenatal testing : screening, diagnosis, and preimplantation genetic diagnosis / Eugene Pergament -- Newborn screening for metabolic disorders / Marzia Pasquali and Nicola Longo -- The role of genetic counseling in everyday medical practice / Kimberly J. Hart, Erin E. Baldwin, and D. Hunter Best -- Direct-to-consumer genetic testing / Caroline F. Wright and Daniel G. MacArthur.
  • 2013 Springer
    Kango-Singh, Madhuri; Singh, Amit.
    Undoubtedly, Drosophila melanogaster, fruit fly, has proven to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on: how does a multi-cellular organism develop from a single-celled embryo? The discovery of the genes responsible for pattern formation has helped refine this question. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, axial patterning, growth regulation in Drosophila eye, and more.
  • 2008
    Summers, Brian Russell.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    D'Amato, Mauro; Rioux, John D.
    Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
  • 2011 Springer
    Grisham, Joe W.; Thorgeirsson, Snorri S.; Wang, Xin Wei.
    Part I. Introduction -- Ch. 1. Biology of heptocellular carcinoma: past, present and beyond -- Ch. 2. Overview of cholangiocarcinoma and evidence for a primary liver carcinoma spectrum -- Part II. Liver cancer development and pathogenesis -- Ch. 3. Pathology of hepatocellular carcinoma -- Part III. Genetics and epidemiology of liver cancer -- Ch. 4. Epidemiology of heptocellular carcinoma -- Ch. 5. Genetics and epidemiology of cholangiocarcinoma -- Part IV. Molecular basis of cancer susceptibility -- Ch. 6. Signaling pathways in viral related pre-neoplastic liver disease and heptocellular carcinoma -- Ch. 7. Epigenetic effects of persistent Hepatitis C virus infection and hepatocellular carcinoma -- Ch. 8. DNA methylation status in chronic liver disease and hepatocellular carcinoma -- Part V. Animal modes -- Ch. 9. Transgenic and knockout mouse models of liver cancer -- Ch. 10. Mosaic cancer mouse models and functional oncogenomics in hepatocellular carcinoma -- Ch. 11. The zebrafish model for liver carcinogenesis -- Part Vi. Global gene expression profiling of human liver cancer -- Ch. 12. Integrative and functional genomics of HCC -- Ch. 13. Molecular signatures of heptocellular carcinoma metastasis -- Ch. 14. Gene mutations and transcriptomic profiles associated to specific subtypes of hepatocellular tumors -- Part VII. Cancer stem cells -- Ch. 15. Cancer stem cells and liver cancer -- Ch. 16. Heterogeneity of liver cancer stem cells -- Ch. 17. Cancer stem cells in liver carcinoma -- Part VIII. Liver cancer genetics in the clinic -- Ch. 18. Moleuclar signaling in hepatocellular carcinoma -- Ch. 19. Molecular events on metastasis of hepatocellular carcinoma -- Ch. 20. Molecular pathogenesis of hepatocellular carcinoma -- Subject Index.
  • 1987 ScienceDirect
    Gottesman, Michael M.
    Also available: Print – 1987
  • 2013 Springer
    Maitra, Anirban; Simeone, Diane M.
    Genomic Alterations in Sporadic Pancreatic Cancer / Marco Dal Molin, Anirban Maitra -- Molecular Pathology of Pancreatic Cancer Precursor Lesions / Lodewijk A. A. Brosens, G. Johan Offerhaus -- Genetic Epidemiology and Pancreatic Cancer / Li Jiao, Donghui Li -- Translational Implications of Molecular Genetics for Early Diagnosis of Pancreatic Cancer / Michael A. Hollingsworth -- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer / Helen Court, Mark R. Philips, Dafna Bar-Sagi -- Molecular Targeted Therapies in Pancreatic Cancer / Edward Kim, Ethan V. Abel, Arunima Ghosh -- Mouse Models of Pancreatic Ductal Adenocarcinoma / Filip Bednar, Marina Pasca di Magliano -- The Genetics of Pancreatic Cancer Progression / Christine A. Iacobuzio-Donahue, -- Epigenetic Alterations in Pancreatic Cancer / Michael Ayars, Michael Goggins -- Innovative Technologies in the Molecular Characterization of Pancreatic Cancer / Iris H. Wei, Chandan Kumar-Sinha.
  • 2007 Springer
    Aguilera, Andrés; Rothstein, Rodney.
    Also available: Print – 2007
  • 2010 Springer
    Gherbawy, Youssuf; Voigt, Kerstin.
  • 2008 Springer
    II Springer
    Schwaiger, Markus; Semmler, W.
    With the increasing interest in the experimental and clinical application of molecular imaging many institutions create research groups or interdisciplinary centers focussing on the complex development process of this new methodology. The aim for this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results.
  • 2005 ScienceDirect
    Day, Richard N.; Periasamy, Ammasi.
  • 2010
    Gambhir, Sanjiv Sam; Rehemtulla, Alnawaz; Ross, Brian D.; Weissleder, Ralph.
    Status: Not Checked OutLane Catalog Record
  • 2009 Springer
    Vallabhajosula, Shankar.
  • NCBI Bookshelf
    This searchable database is a collection of in vivo molecular imaging agents developed for positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultrasound (US), computed tomography (CT), and optical imaging. MICAD, a key component of the "Molecular Libraries and Imaging" program of the NIH Roadmap, is being developed by NCBI, the National Center for Biotechnology Information".
  • 2010 Springer
    Kuge, Yuji; Tamaki, Nagara.
  • 2013 Springer
    Tian, Jie.
    Part I: Molecular Imaging Theory and System -- Introduction -- Molecular Optical Simulation Environment -- Diffuse Optical Tomography -- Fluorescence Molecular Tomography -- Bioluminescence Tomography -- Positron Emission Tomography -- Radioisotope Labeled Molecular Imaging in SPECT -- MRI Facility-Based Molecular Imaging -- Other Molecular Imaging Technology -- Optical Multi-Modality Molecular Imaging -- Medical Image Processing and Analysis -- Part II: Molecular Probes -- Opportunities and Challenges of Radiolabeled Molecular Probes -- Oligonucleotide Probes -- Quantum Dots for Biological Imaging -- RGD-Based Molecular Probes for Integrin v3 Imaging -- Part III: Applications of Molecular Imaging -- Basics of Molecular Biology -- Molecular Imaging Techniques in Clinical Practice of Tumors -- Using Molecular Imaging Techniques to Study Protein-Protein Interactions -- Application of Molecular Imaging in Transgenic Animals -- Molecular Imaging Methods in Diabetes-Related Studies.
  • 2013 Springer
    Riemann, Burkhard; Schober, Otmar.
    The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing significantly. The process of molecular imaging includes key biotarget identification, design of specific molecular imaging probes, and their preclinical evaluation, e.g., in vivo using small animal studies. A multitude of such innovative molecular imaging probes have already entered clinical diagnostics in oncology. There is no doubt that in future the emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation that will optimize diagnostic processes.This handbook addresses all aspects of molecular imaging in oncology, ranging from basic research to clinical applications in the era of evidence-based medicine. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
  • 2012 Springer Protocols
    Gründer, G.
    Instrumentation and Physical Principles / Christoph Weirich and Hans Herzog -- Mathematical Modeling and the Quantification of Brain Dynamics / Albert Gjedde and Dean F. Wong -- Radiopharmaceutical Chemistry / Markus Piel and Frank Rösch -- Introduction to the Basics of Magnetic Resonance Imaging / Klaus Möllenhoff, Ana-Maria Oros-Peusquens, and N. Jon Shah -- Quantification of Cerebral Blood Flow / Adriaan A. Lammertsma -- The Assay of Enzyme Activity by Positron Emission Tomography / Paul Cumming and Neil Vasdev -- Molecular Imaging Studies of Second Messenger Pathways: Looking Deeper than the Membrane / Paul Cumming and Neil Vasdev -- Quantification of Neuroreceptors and Neurotransporters / Hiroshi Ito, Mika Naganawa, Chie Seki, Harumasa Takano, Iwao Kanno, and Tetsuya Suhara -- Measuring Dopamine Synaptic Transmission with Molecular Imaging and Pharmacological Challenges: The State of the Art / Marc Laruelle -- Small Animal Imaging with Positron Emission Tomography / Hideo Tsukada -- Emission Imaging in Dementia / Julie C. Price, Brian J. Lopresti, and Victor L. Villemagne -- Neurochemical Imaging of Addictive Disorders / Allegra Broft and Diana Martinez -- Molecular Imaging of Mood Episodes / Jeffrey H. Meyer -- Molecular Imaging in Schizophrenia / Oliver Howes -- Imaging the Pathophysiology of Ischemic Cerebrovascular Disease / Wolf-Dieter Heiss -- Molecular Imaging of Brain Tumors / Karl-Josef Langen -- Molecular Imaging in Parkinson's Disease / Laura K. Teune and Klaus L. Leenders -- Epilepsy / Alexander Hammers.
  • 2015
    Gambhir, Sanjiv Sam.
    Status: Not Checked OutLane Catalog Record
    Chapter 1. Molecular imaging -- Chapter 2. Basic cell & molecular biology -- Chapter 3. Ovreview of imaging modalities -- Chapter. 4. Molecular imaging strategies -- Chapter 5. Assays -- Chapter 6. Nanoparticle imaging -- Chapter 7. Clinical applications -- Chapter 8. Molecular imaging examples -- Chapter 10. Frequently asked questions -- Chapter 11. Useful tables -- Chapter 12. Probe structures table.
  • 2010
    Gambhir, Sanjiv Sam; Yaghoubi, Shahriar S.
    Status: Not Checked OutLane Catalog Record
    "Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilize. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered here"--Provided by publisher.
  • 2011 Springer
    Wu, Albert M.
    Part 1. Introduction to Glyco-Experiences -- Serendipity in Scientific Discoveries: Some Examples in Glycosciences / Yuan-Chuan Lee -- My 30-Year Devotion to the N-Linked Oligosaccharide Structures / Noriko Takahashi -- Part 2. Blood Group ABH/Le-related Antigens -- Human Blood Group ABH/Ii, Lea,b,x,y, and Sialyl Lea,x Glycotopes; Internal Structures; and Immunochemical Roles of Human Ovarian Cyst Glycoproteins / Albert M. Wu -- Lewis Glyco-Epitopes: Structure, Biosynthesis, and Functions / Hui-Li Chen -- A Unique Endo-β-Galactosidase that Cleaves Both Blood Group A and B Glycotopes / Su-Chen Li, Kimberly M. Anderson and Yu-Teh Li -- Part 3. Lectins -- Recognition Roles of Mammalian Structural Units and Polyvalency in Lectin-Glycan Interactions / Albert M. Wu, Jia-Haw Liu, Tanuja Singh and Zhangung Yang -- Adhesion/Growth-Regulatory Galectins: Insights into Their Ligand Selectivity Using Natural Glycoproteins and Glycotopes / Albert M. Wu, Tanuja Singh, Jia-Hau Liu, Sabine André and Martin Lensch, et al. -- Glycotope Structures and Intramolecular Affinity Factors of Plant Lectins for Tn/T Antigens / Pierre Rougé, Willy J. Peumans, Els J. M. Van Damme, Annick Barre and Tanuja Singh, et al. -- The Five Bacterial Lectins (PA-IL, PA-IIL, RSL, RS-IIL, and CV-IIL): Interactions with Diverse Animal Cells and Glycoproteins / Nechama Gilboa-Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Batya Lerrer and Anne Imberty, et al. -- On the Differential Sialic Acid Specificity of Lectins from Different Parts of Saraca indica / Bishnu P. Chatterjee and Mainak Majumder -- Regulation of Lectin Production by the Human Pathogens Pseudomonas aeruginosa and Chromobacterium violaceum: Effects of Choline, Trehalose, and Ethanol / Nachman C. Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Itschak Axelrad and Nechama Gilboa-Garber -- Non-carbohydrate-Mediated Interaction of Lectins with Plant Proteins / Jared Q. Gerlach, Michelle Kilcoyne, Seron Eaton, Veer Bhavanandan and Lokesh Joshi -- Novel Concepts About the Role of Lectins in the Plant Cell / Els J. M. Van Dammes, Elke Fouquaert, Nausicaä Lannoo, Gianni Vandenborre and Dieter Schouppe, et al. -- Part 4. Structures and Functions of Glycolipids -- Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization / Sandro Sonnino, Vanna Chigorno, Massimo Aureli, Anie Priscilla Masilamani and Manuela Valsecchi, et al. -- 9-O-Acetyl GD3 in Lymphoid and Erythroid Cells / Kankana Mukherjee, Suchandra Chowdhury, Susmita Mondal, Chandan Mandal and Sarmila Chandra, et al. -- GM3 Upregulation of Matrix Metalloproteinase-9 Possibly Through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A Pathways in Mouse Melanoma B16 Cells / Pu Wang, Xiaodong Wang, Peixing Wu, Jinghai Zhang and Toshinori Sato, et al. -- Pathological Roles of Ganglioside Mimicry in Guillain-Barré Syndrome and Related Neuropathies / Robert K. Yu, Toshio Ariga, Seigo Usuki and Ken-ichi Kaida -- Structure and Function of Glycolipids in Thermophilic Bacteria / Feng-Ling Yang, Yu-Liang Yang and Shih-Hsiung Wu -- Lipooligosaccharides of Neisseria Species: Similarity Between N. polysaccharea and N. meningitidis LOSs / Chao-Ming Tsai -- Part 5. Structures and Functions of Complex Carbohydrates -- Roles for N- and O-Glycans in Early Mouse Development / Suzannah A. Williams and Pamela Stanley -- Glycobiology in the Field of Gerontology (Glycogerontology) / Akira Kobata -- Galectins in Regulation of Apoptosis / Fu-Tong Liu, Ri-Yao Yang, Jun Saegusa, Huan-Yuan Chen and Daniel K. Hsu -- Avian and Human Influenza Virus Receptors and Their Distribution / Yasuo Suzuki -- Importance of a Factor VIIIc-Like Glycoprotein Expressed in Capillary Endothelial Cells (eFactor VIIIc) in Angiogenesis / Dipak K. Banerjee, Caroline M. Oliveira, José J. Tavárez, Viswa N. Katiyar and Subiman Saha, et al. -- Mucin O-Glycan Branching Enzymes: Structure, Function, and Gene Regulation / Pi-Wan Cheng and Prakash Radhakrishnan -- Studying Carbohydrate Self-Recognition in Marine Sponges Using Synthetic Aggregation Factor Epitopes / Johannis P. Kamerling and Adriana Carvalho de Souza -- Docking of Chitin Oligomers and Nod Factors on Lectin Domains of the LysM-RLK Receptors in the Medicago-Rhizobium Symbiosis / Pierre Rougé, Wim Nerinckx, Clare Gough, Jean-Jacques Bono and Annick Barre -- Part 6. Glycoimmunology -- O-Acetylated Sialic Acids and Their Role in Immune Defense / Roland Schauer, G. Vinayaga Srinivasan, Dirk Wipfler, Bernhard Kniep and Reinhard Schwartz-Albiez -- Sialylated and Sulfated Carbohydrate Ligands for Selectins and Siglecs: Involvement in Traffic and Homing of Human Memory T and B Lymphocytes / Reiji Kannagi, Katsuyuki Ohmori, Guo-Yun Chen, Keiko Miyazaki and Mineko Izawa, et al. -- Diversity of Natural Anti-α-Galactosyl Antibodies in Human Serum / Elwira Lisowska and Maria Duk -- Significance of Serum Glycoprotein Profiles in Spontaneous Tolerance After Liver Allograft Transplantation / Pei-Weng Wang and Tai-Long Pan -- Part 7. Glycobiology of Cancer -- Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands / Konstantinos Konstantopoulos and Susan N. Thomas -- Regulation of Glycosyltransferase Genes in Apoptotic Breast Cancer Cells Induced by l-PPMP and Cisplatin / Rui Ma, Elizabeth A. Hopp, N. Matthew Decker, Audrey Loucks and James R. Johnson, et al. -- Aberrant Glycosphingolipid Expression and Membrane Organization in Tumor Cells: Consequences on Tumor-Host Interactions / Alessandro Prinetti, Simona Prioni, Nicoletta Loberto, Massimo Aureli and Valentina Nocco, et al. -- Human KDN (Deaminated Neuraminic Acid) and Its Elevated Expression in Cancer Cells: Mechanism and Significance / Sadako Inoue, Ken Kitajima, Chihiro Sato and Shinji Go -- Polysialic Acid Bioengineering of Cancer and Neuronal Cells by N-Acyl Sialic Acid Precursor Treatment / Robert A. Pon, Wei Zou and Harold J. Jennings -- Part 8. Glyco Applications -- Synthesis of Hemagglutinin-Binding Trisaccharides / Cheng-Chung Wang, Suvarn S. Kulkarni, Medel Manuel L. Zulueta and Shang-Cheng Hung -- Fabrication and Applications of Glyconanomaterials / Po-Chiao Lin, Avijit Kumar Adak and Chun-Cheng Lin -- Glycan Arrays to Decipher the Specificity of Plant Lectins / Els J. M. Van Damme, David F. Smith, Richard Cummings and Willy J. Peumans -- Targeting C-Type Lectin for the Treatment of Flavivirus Infections / Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu and Shie-Liang Hsieh.
    Also available: Print – 2011
  • 2003 Wiley
    Komiyama, Makoto.
    ch. 1. Introduction, p. 1-8 -- ch. 2. Fundamentals of Molecular Imprinting, p. 9-19 -- ch. 3. Experimental Methods (1 - Procedures of Molecular Imprinting, p. 21-45 -- ch. 4. Experimental Methods (2 - Evaluation of Imprinting Efficiency, p. 47-52 -- ch. 5. Spectroscopic Anatomy of Molecular Imprinting Reactions, p. 53-64 -- ch. 6. Flow Chart of a Typical Molecular Imprinting, p. 65-73 -- ch. 7. Applications of Molecularly Imprinted Polymers, p. 75-118 -- ch. 8. Recent Challenges and Progress, p. 119-139 -- ch. 9. Conclusions and Prospects, p. 141.
  • 2006 CRCnetBASE
    Hiramatsu, Midori; Packer, Lester; Yoshikawa, Toshikazu.
  • 2010
    Davies, Erin Lane; Baker, Julie C.; Fuller, Margaret T.; Kingsley, David M.; Nusse, Roeland; Villeneuve, Anne M.
    Adult stem cells both self-renew and give rise to differentiating progeny that maintain and repair tissues throughout an individual's lifetime. Adult stem cells reside in specialized microenvironments, or niches, that regulate stem cell behavior in vivo. The Drosophila testis contains a complex niche that maintains two adult stem cell populations, germline stem cells (GSCs) and somatic cyst stem cells (CySCs), which are directly anchored to a plug of post-mitotic support cells called the hub. A short-range, cytokine-like signal from the hub, the ligand Unpaired (Upd), activates the JAK-STAT pathway in adjacent GSCs and CySCs to promote stem cell maintenance. To map the regulatory circuitry downstream of Upd signaling from the hub, I identified genomic sites of STAT binding in GSCs and CySCs by performing chromatin immunoprecipitation with antibodies against activated STAT, followed by high throughput Solexa sequencing (ChIP-Seq). My analysis suggests that forked regulatory circuits lay downstream of activated STAT in GSCs and CySCs, with different tines containing target gene(s) that regulate unique aspects of stem cell identity and behavior, including sustained receptivity to niche signals, expression of transcriptional regulators required for stem cell fate, and cell-cell communication between germline and soma. Adult stem cell behavior is also influenced by cell-intrinsic factors, including transcription and chromatin remodeling factors, which enable stem cells to interpret and execute appropriate responses to niche signals. I discovered that the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for GSC and CySC maintenance: stem cells homozygous mutant for lola detach from the hub and differentiate. In addition, I found that activity of lola is also required for proper execution of key developmental transitions during germ cell differentiation, including the timely switch from the transit amplification divisions to the spermatocyte growth and gene expression program, and subsequently for the meiosis and spermatid differentiation.
  • 2014 Springer
    Hilbi, Hubert.
    Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
  • 2012
    Palin, Amy Colleen; Contag, Christopher H.; Lewis, David B.; Martinez, Olivia; Utz, Paul J.
    Human neonates are highly susceptible to infection by intracellular pathogens compared to adults, due in large part to a reduction in CD4+ T cell-mediated T helper type 1 (Th1) immunity. We have investigated the molecular mechanisms in the neonatal naive CD4+ T cell response that contribute to this reduction in neonatal Th1 immunity, and have identified differences in gene expression, epigenetic regulation, and T cell receptor signaling between neonatal an adult naive CD4+ T cells. Significantly, neonatal naive CD4+ T cells flux calcium to a higher degree than do adult naive CD4+ T cells in response to CD3 engagement. This enhanced calcium signaling is mediated by higher levels of the microRNA miR-181a, and is not accompanied by an increase in response to CD28-mediated costimulation. In neonatal cells, an increase in calcium signaling relative to a lack of induction of the AP-1 transcription factor indicates that neonatal naive CD4+ T cells may be prone to an anergic response. Neonatal naive CD4+ T cells share an enhanced calcium response with adult CD4+ recent thymic emigrants, a less mature peripheral CD4+ T cell population. We have also confirmed decreased capacity of neonatal naive CD4+ T cells to produce the prototypic Th1 cytokine interferon-gamma (IFN-[gamma]), and have obtained evidence that epigenetic modifications mediated by de novo methyltransferase 3a (Dnmt3a) are responsible for impaired cytokine production. Comprehensive profiling of gene expression and microRNA expression have uncovered further support for our functional observations of increased calcium flux and reduced Th1 function in neonatal naive CD4+ T cells. We have found that neonatal naive CD4+ T cells have reduced Th1 function and have enhanced T cell receptor proximal signaling in the absence of an enhanced response to costimulation, constituting a unique T cell phenotype.
  • 2008 Springer
    Cheng, C. Yan.
    Spermatogenesis and cycle of the seminiferous epithelium / Rex A. Hess and Luiz Renato de Franca -- Testicular development and spermatogenesis : harvesting the postgenomics bounty / Antoine D. Rolland, Bernard Jogou and Charles Pineau -- Estrogens and spermatogenesis / Chandrima Shaha -- Selenium, a key element in spermatogenesis and male fertility / Carla Boitani and Rossella Puglisi -- Extracellular matrix and its role in spermatogenesis / Michelle K.Y. Siu and C. Yan Cheng -- Inflammatory networks in the control of spermatogenesis : chronic inflammation in an immunologically privileged tissue? / Moira K. O'Bryan and Mark P. Hedger -- Transcription regulation in spermatogenesis / Wing-Yee Lui and C. Yan Cheng -- Proteases and their cognate inhibitors of the serine and metalloprotease -- Subclasses, in testicular physiology / Brigitte Le Magueresse-Battistoni -- Antioxidant systems and oxidative stress in the testes / R. John Aitken and Shaun D. Roman -- Nitric oxide and cyclic nucleotides : their roles in junction dynamics and spermatogenesis / Nikki P.Y. Lee and C. Yan Cheng -- The sertoli cell cytoskeleton / A. Wayne Vogl, Kuljeet S. Vaid and Julian A. Guttman -- Blood-testis barrier, junctional and transport proteins and spermatogenesis / Brian P. Setchell -- Cross-talk between tight and anchoring junctions : lesson from the testis / Helen H.N. Yan ... [et al.] -- The role of the leydig cell in spermatogenic function / Renshan Ge, Guorong Chen and Matthew P. Hardy.
  • 2010 Karger
    Rudolph, K. Lenhard.
    Speakers at the Symposium / Hartmann, D. -- Hematopoietic stem cell aging and fate decision / Illing, A., Ju, Z. -- Alterations of systemic environment impair stem cell function during aging / Song, Z., Ju, Z. -- Novel insights into regulation of stem cell aging by aging of the niche and alterations in systemic factors / Geiger, H. -- Aging and hematopoietic malignancies / Gompf, A. -- Intestinal stem cell aging / Sperka, T., Rudolph, K.L. -- Molecular mechanisms of aging in muscle stem cells / Tümpel, S. -- Free radicals and stem cell aging / Guachalla, L.M. -- DNA damage, checkpoint responses, and cell cycle control in aging stem cells / Sperka, T., Nalapareddy, K., Rudolph, K.L.
  • 2005 Springer
    Amendt, Brad A.
    Identification of the gene involved in 4q25-linked Axenfeld-Rieger syndrome, PITX2 / Elena V. Semina -- Winged helix/forkhead transcription factors and Rieger syndrome / Darryl Y. Nishimura and Ruth E. Swiderski -- Rieger syndrome and PAX6 deletion / Ruth Riise -- The molecular and biochemical basis of Axenfeld-Rieger syndrome / Brad A. Amendt -- Role of PITX2 in the pituitary gland / Hoonkyo Suh ... [et al.] -- Expression and function of PITX2 in chick heart looping / Xueyan Yu, Shusheng Wang, and YiPing Chen -- The multiple roles of PITX2 in heart development / James F. Martin -- The role of PITX2 in tooth development / Brad A. Amendt -- PITX genes and ocular development / Elena V. Semina -- An overview of Axenfeld-Rieger syndrome and the anterior segment developmental disorders / Brad A. Amendt.
  • 2009 Springer
    Sasakawa, Chihiro.
    Functional morphology of the gastrointestinal tract / L. Shen -- Vibrio cholerae interactions with the gastrointestinal tract: Lessons from animal studies / J.M. Ritchie and M.K. Waldor -- Interaction of Yersinia with the gut: Mechanisms of pathogenesis and immune evasion / P. Dube -- Molecular mechanisms of Salmonella virulence and host resistance / Y. Valdez, R.B.R. Ferreira and B.B. Finlay -- Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori / tW. Fischer, S. Prassl and R. Haas -- Listeria as an enteroinvasive gastrointestinal pathogen / S.B. Barbuddhe and T. Chakraborty -- Molecular mechanisms of Campylobacter infection / J.P.M. Putten ... [et al.] -- Shigella infection of intestinal epithelium and circumvention of the host innate defense system / H. Ashida ... [et al.].
    Also available: Print – 2009
  • 2006 Springer
    Reichrath, J.
    The epidemiology of basal cell and squamous cell carcinoma / Hao Wang and Thomas L. Diepgen -- Histology of epithelial skin tumors / Jörg Reichrath and Kerstin Querings -- UV damage and DNA repair in basal cell and squamous cell carcinomas / Knuth Rass -- Papillomavirus infections and cancerogenesis of squamous cell and basal cell carcinomas / Guido Bens -- The immune system and nonmelanoma skin cancers / Elma D. Baron -- Cytogenetics of basal cell carcinoma and squamous cell carcinomas / Melanie A. Carless, Kevin J. Ashton and Lyn R. Griffiths -- The hedgehog signaling pathway and epithelial skin cancer / Julia Reifenberger -- p53 protein and nonmelanoma skin cancer / Vladislava O. Melnikova and Honnavara N. Ananthaswamy -- TGF-[beta] pathway and cancerogenesis of epithelial skin tumors / Miguel Quintanilla ... [et al.] -- PDGF pathways and growth of basal cell and squamous cell carcinomas / Jingwu Xie -- Apoptosis and cancerogenesis of basal cell and squamous cell carcinoma / Peter Erb ... [et al.] -- The role of telomerase for cancerogenesis of basal cell and squamous cell carcinomas / Eva-Maria Fabricius.
  • 2007 Springer
    Weber, Georg F.
    Theories of carcinogenesis -- Physioloigic correlates of malignancy -- Cell division and survival -- Cellular senescence -- Invasiveness -- DNA repair -- Epigenetic regulation of cancer-associated gene products -- Interaction of the groups of cancer-related gene products -- Structural growth control -- The organ preference of metastasis formation -- Angiogenesis -- Interactions with the immune system -- Endocrine dysregulation -- Dormancy and minimal residual disease -- Epithelial tumors -- Hematologic malignancies -- Mesenchymal tumors -- Neurologic tumors -- Tumors of serous cavities -- Embryonic tumors.
  • 2006 Springer
    Ahmad, Shamim I.; Kirk, Sandra H.
    Clinical features of Fanconi anaemia / A. Malcolm, R. Taylor -- The genetic basis of Fanconi anemia / Grover C. Bagby, Jr. -- The FANCA gene and its products / Laura S. Haneline -- The FANCC gene and its products / Susan M. Gordon and Manuel Buchwald -- The FANC B, E, F and G genes and their products / Filippo Rosselli -- FANCD1/BRCA2 and FANCD2 / Gary M. Kupfer -- The FANC genome surveillance complex / Takayuki Yamashita -- Other proteins and their interactions with FA gene products / Tetsuya Otsuki and Johnson M. Liu -- Fanconi anaemia and oxidative stress: cellular and clinical phenotypes / Giovanni Pagano and Shamim I. Ahmad -- Therapy for Fanconi anemia / Madeleine Carreau -- Mutational analyses of Fanconi anemia genes in Japanese patients / Akira Tachibana.
  • 2009
    Pentecost, Mickey Joseph.
    Status: Not Checked OutLane Catalog Record
  • 2008 Springer
    Burleigh, Barbara A.; Soldati, Dominique.
    Current and emerging approaches to studying invasion in apicomplexan parasites / Jeffrey Mital and Gary E. Ward -- Microneme proteins in apicomplexans / Vern B. Carruthers and Fiona M. Tomley -- Erythrocyte invasion by plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching / Manoj T. Duraisingh ... [et al.] -- Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of trypanosoma cruzi with host structures / Maria Jølia M. Alves and Walter Colli -- Calcium regulation and signaling in apicomplexan parasites / Kisaburo Nagamune ... [et al.] -- Trypanosoma cruzi: parasite and host cell signaling during the invasion process / Nobuko Yoshida and Mauro Cortez -- Host cell actin remodeling in response to cryptosporidium / Steven P. O'Hara ... [et al.] -- Host cell actin remodeling in response to trypanosoma cruzi: trypomastigote versus amastigote entry / Renato A. Mortara ... [et al.] -- Actin/myosin-based gliding motility in apicomplexan parasites / Kai Matuschewski and Herwig Schøler -- Roles of proteases during invasion and egress by plasmodium and toxoplasma / Timothy J. Dowse ... [et al.] -- Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by trypanosoma cruzi / Julio Scharfstein and Ana Paula C.A. Lima -- Biogenesis of and activities at the toxoplasma gondii parasitophorous vacuole membrane / Anthony P. Sinai. The role of host cell lysosomes in trypanosoma cruzi invasion / G. Adam Mott and Barbara A. Burleigh -- Leishmania invasion and phagosome biogenesis / Robert Lodge and Albert Descoteaux -- Plasmodium sporozoite passage across the sinusoidal cell layer / Ute Frevert ... [et al.] -- Transepithelial migration by toxoplasma / Antonio Barragan and Niclas Hitziger -- The microsporidian polar tube and its role in invasion / Frederic Delbac and Valerie Polonais -- Intestinal invasion by entamoeba histolytica / Shahram Solaymani-Mohammadi and William A. Petri, Jr.
  • 2009
    Patel, Maulik R.
    Status: Not Checked OutLane Catalog Record
  • 2009 Springer
    Díaz-Peña, Roberto; López-Larrea, Carlos.
    Clinical assessment in the spondyloarthropathies / Ruth Wittoek and Herman Mielants -- Imaging in spondyloarthritis / Walter P. Maksymowych -- Spondyloarthritis, diffuse idiopathic skeletal hyperostosis (DISH), and chondrocalcinosis / Jácome Brugues Armas, Ana Rita Couto, and Bruno Filipe Bettencourt -- The enthesis organ concept and its relevance to the spondyloarthropathies / Michael Benjamin and Dennis McGonagle -- Synovial and mucosal immunopathology in spondyloarthritis / Bernard Vandooren, Paul P. Tak, and Dominique Baeten -- Bone loss in the spondyloarthropathies : role of osteoclast, RANKL, RANK, and OPG in the spondyloarthropathies / Allen P. Anandarajah and Edward M. Schwarz -- RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies / Andreas Leibbrandt and Josef M. Penninger -- Bone formation versus bone resorption in ankylosing spondylitis / Georg Schett -- Biomarkers in spondyloarthropathies / Chun-Hsiung Chen, David Tak Yan Yu, and Chung-Tei Chou -- Therapy of spondyloarthritides / Jürgen Braun -- Genomewide screens in ankylosing spondylitis / Matthew A. Brown -- Subtypes of HLA-B27 : history and implications in the pathogenesis of ankylosing spondylitis / John D. Reveille -- Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis / Andreas Ziegler ... [et al.] -- HLA-B27-bound peptide repertoires : their nature origin and pathogenetic relevance / José A. López de Castro.
    Also available: Print – 2009
  • 2007
    Luik, Riina M.
    Status: Not Checked OutLane Catalog Record
  • 2006 Springer
    Dityatev, Alexander; El-Husseini, Alaa.
    Pt. 1. Experimental models of synaptogenesis -- Pt. 2. Roles of cell adhesion and secreted molecules in synaptic differentiation -- Pt. 3. Transport of synaptic proteins -- Pt. 4. Synaptic cytoskeleton and morphogenic signaling -- Pt. 5. Synaptic plasticity in learning and memory -- Pt. 6. Synaptogenesis and brain disorders.
  • 2010
    Jones, Jonathan Wiley; Amieva, M. R.; Falkow, Stanley; Monack, Denise M.; Nelson, W. J.; Schneider, David.
    Francisella tularensis is a facultative intracellular pathogen that causes the disease tularemia. The ability of F. tularensis to escape phagosomal degradation and replicate in the macrophage cytosol is central to its pathogenesis. The macrophage responds to the presence of cytosolic F. tularensis with the production of type-I interferons (IFN) and subsequent activation of the inflammasome. We conducted a forward genetic screen of a F. novicida transposon library to identify mutants that resulted in an increased or decreased cytosolic response in macrophages. We identified 164 F. novicida mutants that lead to increased type-I IFN production and inflammasome activation in macrophages. We also identified 74 mutants that resulted in decreased type-I IFN and inflammasome responses in macrophages. Finally, we identified AIM2 as the host receptor responsible for inflammasome activation in response to cytosolic F. novicida. We showed that lysing cytosolic F. novicida leads to release of bacterial DNA that triggers type-IFN through a pathway involving the adaptor STING. STING-dependent type-I IFN production increases the expression of AIM2, which complexes with the bacterial DNA and initiates inflammasome activation. We further demonstrate that AIM2 is critical for innate immunity to F. novicida infection in vivo. Thus we identified a novel bacterial ligand and novel cytosolic sensing components that play a role in the host defense to bacterial infections.
  • 2013 Springer
    Bonavida, Benjamin.
    Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors. This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.
  • 2008
    Ahmad, Shamim I.; Hanaoka, Fumio.
    Historical aspects of xeroderma pigmentosum and nucleotide excision repair / James E. Cleaver -- Clinical features of xeroderma pigmentosum / Ulrich R. Hengge and Steffen Emmert -- Xeroderma pigmentosum and skin cancer / Leela Daya-Grosjean -- XPA gene, its product and biological roles / Ulrike Camenisch and Hanspeter Nogeli -- XPB and XPD between transcription and DNA repair / Brian D. Beck, Dae-Sik Hah, and Suk-Hee Lee -- XPC: its product and biological roles / Kaoru Sugasawa -- The XPE gene of xeroderma pigmentosum : its product and biological roles / Drew Bennett and Toshiki Itoh -- XPF/ERCC4 and ERCC1 : their products and biological roles / Lisa D. McDaniel and Roger A. Schultz -- XPG: its products and biological roles / Orlando D. Schorer -- Xeroderma pigmentosum variant, XPV: its product and biological roles / Chikahide Masutani, Fumio Hanaoka, and Shamim I. Ahmad -- Other proteins interacting with XP proteins / Steven M. Shell and Yue Zou -- The nucleotide excision repair of DNA in human cells and its association with xeroderma pigmentosum / Alexei Gratchev -- Roles of oxidative stress in xeroderma pigmentosum / Masaharu Hayashi -- Xeroderma pigmentosum : its overlap with trichothiodystrophy, Cockayne syndrome, and other progeroid syndromes / W. Clark Lambert, Claude E. Gagna, and Muriel W. Lambert -- Population distribution of xeroderma pigmentosum / Abdul Manan Bhutto and Sandra H. Kirk -- Progress and prospects of xeroderma pigmentosum therapy / Alain Sarasin -- Animal models of xeroderma pigmentosum / Xue-Zhi Sun ... [et al.].
  • 2011
    Viswanathan, Kartik; Giaccia, Amato J.; Kim, Seung K.; Kuo, Calvin Jay; Wysocka, Joanna.
    Pancreatic [Beta]-cells secrete insulin to maintain systemic glucose balance. In response to physiological or pathological stresses that increase insulin demand, [Beta]-cells proliferate and enhance insulin secretion to increase insulin output. However, the mechanisms that govern these facultative changes are unclear. In this thesis, I investigate two potential factors in achieving these essential adaptive changes -- hypoxia inducible factor 1 alpha (Hif1a) and prolactin receptor (Prlr). During pregnancy, a common acquire state with increased insulin demand, Hif1a and Hif1a target gene expression, including Vegfa, Glut1, Gck were increased in maternal islets. Using mouse genetics, conditional deletion of Hif1a in [Beta]-cells ([Beta]Hif1a KO) resulted in glucose intolerance in pregnant, but not virgin, mice. Pregnant [Beta]Hif1a KO mice had impaired target gene expression, defective islet insulin secretion, and reduced vascularity. Pregnant mice develop transient hyperlipidemia, and recapitulation of the hyperlipidemia with fat-challenge or lipid treament induced Hif1a, Vegfa, and Pgk1 expression. Similar to pregnant [Beta]Hif1a KO mice, fat-challenged [Beta]Hif1a KO developed hyperglycemia, hypoinsulinemia, and glucose intolerance. All three hyperlipidemic states show ER stress, and treatment of unstressed mouse or human islets with thapsigargin was sufficient to increase Hif1a and downstream targets. To assess the significance of prolactin signaling in [Beta]-cell function and proliferation in adaptive settings, I created a novel conditional Prlr mouse model. In non-pregnant mice with [Beta]-cell-specific deletion of Prlr ([Beta]Prlr KO), glucose homeostasis is normal. However, pregnant [Beta]Prlr KO mice developed significant glucose intolerance. Given the widespread effects of lactogens on [Beta]-cell physiology, I anticipate altered [Beta]-cell proliferation and secretion in [Beta]Prlr KO islets, and current studies are underway to address this hypothesis. Collectively, our work has revealed that in settings of insulin resistance, both Hif1a and Prlr signaling play important roles in regulating the physiological changes required for proper [Beta]-cell function.
  • 2002 ScienceDirect
    Sussman, Max.
  • 2003 ScienceDirect
    Komuniecki, Richard; Marr, J. Joseph; Nilsen, Timothy W.
    Sect. I. Molecular Biology -- Ch. 1. Parasite genomics -- Ch. 2. RNA processing in parasitic organisms: trans-splicing and RNA editing -- Ch. 3. Transcription -- Ch. 4. Post-transcriptional regulation -- Ch. 5. Antigenic variation in African trypanosomes and malaria -- Ch. 6. Genetic and genomic approaches to the analysis of leishmania virulence -- Sect. II. Biochemistry and Cell Biology: Protozoa -- Ch. 7. Energy metabolism -- Ch. 8. Amino acid and protein metabolism -- Ch. 9. Purine and pyrimidine transport and metabolism -- Ch. 10. Trypanosomatid surface and secreted carbohydrates -- Ch. 11. Intracellular signaling -- Ch. 12. Plastids, mitochondria, and hydrogenosomes -- Sect. III. Biochemistry and Cell Biology: Helminths -- Ch. 13. Helminth surfaces: structural, molecular and functional properties -- Ch. 14. Carbohydrate and energy metabolism in parasitic helminths -- Ch. 15. Neurotransmitters -- Sect. IV. Medical Applications -- Ch. 16. Drug resistance in parasites -- Ch. 17. Medical implications of molecular parasitology.
  • 2012 ScienceDirect
    2012 ClinicalKey
    Trent, R. J.
    Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances. Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicineThe only book in Molecular Medicine to reach its fourth edition Identifies current practice as well as future developmentsPresents extensive tables, well presented figures and resources for further understanding.
  • 2011 Springer Protocols
    Orgogozo, Virginie; Rockman, Matthew V.
    Characterizing the genome. Genome size determination using flow cytometry of propidium iodide-stained nuclei / Emily E. Hare and J. Spencer Johnston. Chromosome analysis in invertebrates and vertebrates / David M. Rowell, Shu Ly Lim, and Frank Grutzner. Genomic libraries : I. Constuction and screening of fosmid genomic libraries / Mike A. Quail [and others] Genomic libraries : II. Subcloning, sequencing, and assembling large-insert genomic DNA clones / Mike A. Quail [and others] -- Targeting regions of the genome. Reduced representation methods for subgenomic enrichment and next-generation sequencing / Jeffrey M. Good. Accessing the transcriptome : how to normalize mRNA pools / Heiko Vogel and Christopher W. Wheat. Transcriptome sequencing goals, assembly, and assessment / Christopher W. Wheat and Heiko Vogel. Rapid retrieval of DNA target sequences by primer extension capture / Adrian W. Briggs -- Measuring genetic diversity. SNP discovery and genotyping for evolutionary genetics using RAD sequencing / Paul D. Etter [and others] DNA microarray-based mutation discovery and genotyping / David Gresham. Genotyping with Sequenom / Martina Bradić, João Costa, and Ivo M. Chelo. Isolating microsatellite loci : looking back, looking ahead / José A. Andrés and Steven M. Bogdanowicz. Design of custom oligonucleotide microarrays for single species or interspecies hybrids using array olico selector / Amy A. Caudy -- Obtaining candidate gene sequences. Identification of homologous gene sequences by PCR with degenerate primers / Michael Lang and Virginie Orgogozo -- Characterizing cDNA ends by circular RACE / Patrick T. McGrath. Identification of DNA sequences that flank a known region by inverse PCR / Anastasios Pavlopoulos -- Analyzing candidate gene transcripts. Quantification of transcript levels with quantitative RT-PCR / Karen L. Carleton. Using pyrosequencing to measure allele-specific mRNA abundance and infer the effects of cis- and trans-regulatory differences / Patricia J. Wittkopp. Whole-mount in situ hybridization of sectioned tissues of species hybrids to detect cis-regulatory changes in gene expression pattern / Ryo Futahashi. Identifying fluorescently labeled single molecules in image stacks using machine learning / Scott A. Rifkin -- Testing candidate genes and candidate mutations. Experimental approaches to evaluate the contributions of candidate cis-regulatory mutations to phenotypic evolution / Mark Rebeiz and Thomas M. Williams. Experimental approaches to evaluate the contributions of candidate protein-coding mutations to pheotypic evolution / Jay F. Storz and Anthony J. Zera. Making reporter gene constructs to analyze cis-regulatory elements / José Bessa and José Luis Gómez-Skarmeta. PCR directed in vivo plasmid construction using homologous recombination in baker's yeast / Erik C. Andersen. Production of fosmid genomic libraries optimized for liquid culture recombineering and cross-species transgenesis / Radoslaw Kamil Ejsmont [and others] Recombination-mediated genetic engineering of large genomic DNA transgenes / Radoslaw Kamil Ejsmont [and others] Overlap extension PCR : an efficient method for transgene construction / Matthew D. Nelson and David H.A. Fitch. Gene knockdown analysis by double-stranded RNA injection / Benjamin N. Philip and Yoshinori Tomoyasu.
  • 2007 Springer
    Nies, Dietrich H.; Silver, S.
  • 2005 Springer
    Oldstone, Michael B. A.
    Molecular mimicry, microbial infection, and autoimmune disease : evolution of the concept / M.B.A. Oldstone -- The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination / K.W. Wucherpfennig -- A virus-induced molecular mimicry model of multiple sclerosis / J.K. Olson, A.M. Ercolini, and S.D. Miller -- Suppression of autoimmunity via microbial mimics of altered peptide ligands / L. Steinman, P.J. Utz, and W.H. Robinson -- Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry / M.B.A. Oldstone -- Trypanosoma cruzi-induced molecular mimicry and Chagas' disease / N. Gironès, H. Cuervo, and M. Fresno -- HTLV-1 induced molecular mimicry in neurological disease / S.M. Lee ... [et al.] -- Molecular mimicry : anti-DNA antibodies bind microbial and nonnucleic acid self-antigens / J.S. Rice ... [et al.] -- Chlamydia and antigenic mimicry / K. Bachmaier and J.M. Penninger.
    Also available: Print – 2005
  • 2012 CRCnetBASE
    Rai, Beena.
    "Preface Over the past few decades, molecular modeling (MM) has become an important tool in many academic institutions and industrial laboratories. While the role of MM in biological fields--especially in the design and development of novel drug molecules or formulations--is well established and acknowledged, its direct role in the design and development of performance chemicals and novel materials is still not well known. Questions such as, which new products have resulted from an MM-based approach? are still often asked. Although MM may be playing an important role in product development, quite often it becomes difficult to predict its direct impact because most of the time the problem being addressed involves a multidisciplinary approach. Further, the assumption that fundamental phenomena being modeled though MM will have a direct impact on the macroscopic and functional properties of a product make the situation more complicated. In most of the cases, MM actually works as an enabler toward novel product and material development (e.g., novel drug molecules in biological application) rather than directly coming up with new products and materials. This precisely is the reason that despite seeing value in MM tools, most engineers and practitioners are often focus on the question, how do I leverage these tools to design and develop novel materials or chemicals for the industry I am working with? Unfortunately, there is no simple answer to this question. Excellent books and very good research publications highlight the most intricate, fundamental, and theoretical details about MM techniques and tools"-- Provided by publisher.
  • 2015 Springer Protocols
    Kukol, Andreas.
    Molecular dynamics simulations / Erik R. Lindahl -- Monte Carlo simulations / David J. Earl and Michael W. Deem -- Hybrid quantum and classical methods for computing kinetic isotope effects of chemical reactions in solutions and in enzymes / Jiali Gao ... [et al.] -- Comparison of protein force fields for molecular dynamics simulations / Olgun Guvench and Alexander D. MacKerell, Jr. -- Normal modes and essential dynamics / Steven Hayward and Bert L. de Groot -- Calculation of absolute protein-ligand binding constants with the molecular dynamics free energy perturbation method / Hyung-June Woo -- Free energy calculations applied to membrane proteins / Christophe Chipot -- Molecular dynamics simulations of membrane proteins / Philip C. Biggin and Peter J. Bond -- Membrane-associated proteins and peptides / Marc F. Lensink -- Implicit membrane models for membrane protein simulation / Michael Feig -- Comparative modeling of proteins / Gerald H. Lushington -- Transmembrane protein models based on high-throughput molecular dynamics simulations with experimental constratints / Andrew J. Beevers and Andreas Kukol -- Nuclear magnetic resonance-based modeling and refinement of protein three-dimensional structures and their complexes / Gloria Fuentes, Aalt D.J. van Dijk, and Alexandre M.J.J. Bonvin -- Conformational changes in protein function / Haiguang Liu ... [et al.] -- Protein folding and unfolding by all-atom molecular dynamics simulations / Hongxin Lei and Yong Duan -- Modeling of protein misfolding in disease / Edyta B. Małolepsza -- Identifying putative drug targets and potential drug leads : starting points for virtual screening and docking / David S. Wishart -- Receptor flexibility for large-scale in silico ligand screens : chances and challenges / B. Fischer, H. Merlitz, and W. Wenzel -- Molecular docking / Garrett M. Morris and Marguerita Lim-Wilby.
  • 2008 Springer Protocols
    Kukol, Andreas.
    Molecular dynamics simulations / Erik R. Lindahl -- Monte Carlo simulations / David J. Earl and Michael W. Deem -- Hybrid quantum and classical methods for computing kinetic isotope effects of chemical reactions in solutions and in enzymes / Jiali Gao ... [et al.] -- Comparison of protein force fields for molecular dynamics simulations / Olgun Guvench and Alexander D. MacKerell, Jr. -- Normal modes and essential dynamics / Steven Hayward and Bert L. de Groot -- Calculation of absolute protein-ligand binding constants with the molecular dynamics free energy perturbation method / Hyung-June Woo -- Free energy calculations applied to membrane proteins / Christophe Chipot -- Molecular dynamics simulations of membrane proteins / Philip C. Biggin and Peter J. Bond -- Membrane-associated proteins and peptides / Marc F. Lensink -- Implicit membrane models for membrane protein simulation / Michael Feig -- Comparative modeling of proteins / Gerald H. Lushington -- Transmembrane protein models based on high-throughput molecular dynamics simulations with experimental constraints / Andrew J. Beevers and Andreas Kukol -- Nuclear magnetic resonance-based modeling and refinement of protein three-dimensional structures and their complexes / Gloria Fuentes, Aalt D.J. van Dijk, and Alexandre M.J.J. Bonvin -- Conformational changes in protein function / Haiguang Liu ... [et al.] -- Protein folding and unfolding by all-atom molecular dynamics simulations / Hongxin Lei and Yong Duan -- Modeling of protein misfolding in disease / Edyta B. Małolepsza -- Identifying putative drug targets and potential drug leads : starting points for virtual screening and docking / David S. Wishart -- Receptor flexibility for large-scale in silico ligand screens : chances and challenges / B. Fischer, H. Merlitz, and W. Wenzel -- Molecular docking / Garrett M. Morris and Marguerita Lim-Wilby.
  • 2005 CRCnetBASE
    Hacker, Gerhard W.; Tubbs, Raymond R.
  • ScienceDirect
    Vallee, Richard B.
    Also available: Print – 1991
  • ScienceDirect
    Vallee, Richard B.
    Also available: Print – 1998
  • 2013 Springer
    Blum, Kenneth.
    Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as the "reward center" of the brain, where a number of chemical messengers work in concert to provide a net release of dopamine in the Nucleus Accumbens. In some genetically predisposed individuals, addiction occurs when the mechanisms of the mesolimbic system are disrupted by the use of various drugs of abuse. Since Alcoholics Anonymous was founded in 1935, it's 12 step program of spiritual and character development has helped countless alcoholics and drug addicts curb their self-destructive behaviors. However, the program was developed at a time when comparatively little was known about the function of the brain and it has never been studied scientifically. This is the first book to take a systematic look at the molecular neurobiology associated with each of the 12 steps and to review the significant body of addiction research literature that is pertinent to the program.
  • 2009
    Nestler, Eric J.; Hyman, Steven E.; Malenka, Robert C.
    Status: Not Checked OutLane Catalog Record
  • 2005 Springer
    Lappi, Douglas A.; Wiley, Ronald G.
    Introduction to molecular neurosurgery / Ronald G. Wiley and Douglas A. Lappi -- Ribosome-inactivating proteins / Fiorenzo Stirpe -- Biochemical, physiological, and behavioral characterizations of the cholinergic basal forebrain lesion produced by 192 IgG-saporin / Jerene J. Waite -- Basal forebrain cholinergic lesion by 192 IgG-saporin: a tool to assess the consequences of cortical cholinergic dysfunction in Alzheimers disease / Reinhard Schliebs -- 192 IgG-saporin-induced partial cortical cholinergic deafferentation as a model for determining the interactions between brain aging and neurodevelopmental defects in the cortical cholinergic input system / Martin Sarter and John P. Bruno -- Exploring the role of acetylcholine in primate cognition using Me20.4 IgG-saporin / Rosalind M. Ridley and Harry F. Baker -- Cortical cholinergic deafferentation induces A-beta deposition: towards a physiologic animal model of Alzheimer's disease / Thomas G. Beach ... [et al.] -- Chemical dissection of brain glucoregulatory circuitry / Sue Ritter ... [et al.] -- Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin / Patrice G. Guyenet, Ruth L. Stornetta, and Ann M. Schreihofer -- Saporin conjugates and pain / Ronald G. Wiley and Douglas A. Lappi -- The use of saporin conjugates to dissect neurons responsible for sleep and wakefulness / Carlos Blanco-Centurion ... [et al.] -- Isolectin I-B4-mediated cytotoxic targeting of sensory neurons / Lucy Vulchanova and Christopher N. Honda -- B fragment of cholera toxin conjugated to saporin / Peter T. O'hara, Kanwarjit Kelley, and Luc Jasmin.
    Also available: Print – 2005
  • 2015 Springer
    Dumur, Catherine Isabelle; Garrett, Carleton T.; Idowu, Michael Ola.
    Part I. Overview of Basic Cellular Biology -- 1. Normal molecular biology and definition of terms -- 2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins -- 3. Standard nomenclature -- introduction and brief overview -- Part II. Molecular Oncology Methodology -- 4. General principles of Oncology testing -- 5. Molecular methodologies -- 6. General principles of validating a molecular test -- Part III. Molecular testing in Solid Tumors -- 7. Lung and mediastinum -- 8. Breast -- 9. Head and neck (salivary glands) -- 10. Thyroid and parathyroid (endocrine) -- 11. Gastrointestinal and Pancreatobiliary -- 12. Soft tissue -- 13. Genitourinary system -- 14. Central Nervous System -- 15. Skin and adnexa -- 16. Common Hereditary Cancer Syndromes -- Part IV. The future is here -- 17. Application of next generation sequencing -- Part V. Quality Assurance and Regulatory affairs -- 18. Quality Assurance -- pre-analytic, analytic and post-analytic -- 19. Regulatory affairs (including accreditation) -- 20. Coding and re-imbursement.
  • 2007 Springer
    Zhuo, Min.
    Genes, neurons and neurotransmission -- Glutamate, excitatory transmission and pain -- Neuropeptides, ATP, retrograde messengers and opioids -- Inhibitory transmission and plasticity -- Postsynaptic signaling and gene regulation -- Peripheral nociceptor, amygdala and fear -- Spinal plasticity, reorganization and chronic pain -- Cortical plasticity, reorganization and amputation -- Endogenous analgesia and other form of analgesia -- Models for studying pain and searching for pain killers.
  • 2006 Springer
    Nickerson, Cheryl A.; Schurr, Michael J.
    Genetic analysis of bacterial pathogenesis -- Genetic exchance in bacteria and the modular stucture of mobile DNA elements -- Genomics and the use of genomic tools to study pathogenic bacteria -- Pathogenicity islands and bacterial virulence -- Capsules -- Bacterial cell walls -- Mechanisms of bacterial adhesion and consequences of attachment -- Bacterial invasion into non-phagocytic cells -- Bacterial protein secretion mechanisms -- Toxins as host cell modulators -- Quorum sensing: coordinating group behavior through intercellular signals -- The role of sigma factors in regulating bacterial stress responses and pathogenesis -- Two-component regulatory systems -- Oxidative stress systems in bacteria: four model organisms -- Bacterial biowarfare agents.
    Also available: Print – 2006
  • 2005 Springer
    Milz, S.; Benjamin, M.; Putz, Reinhard.
  • 2013 Springer
    Haigis, Kevin M.
    Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
  • 2014 Springer
    Coppola, Domenico.
    Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
  • 2007 Springer
    Leonard, Debra G. B.
    Basics of molecular biology -- Molecular pathology methods -- Genetic counseling -- Pedigree analysis and risk assessment -- Bayesian analysis -- Developmental disabilities -- Neuromuscular diseases -- Molecular genetic testing for metabolic disorders -- Fibroblast growth factor receptor-related skeletal disorders -- Cystic fibrosis -- Deafness -- Coagulation disorders -- Hematologic disorders : hemochromatosis, hemoglobinopathies, and Rh incompatibility -- Cardiovascular disease -- Neurodegenerative disorders -- Skin and connective tissue disorders -- Inherited breast cancer -- Familial adenomatous polyposis and Turcot and Peutz-Jeghers syndromes -- Hereditary nonpolyposis colorectal cancer -- Multiple endocrine neoplasia syndromes -- The neurofibromatoses -- TP53 mutation and Li-Fraumeni syndrome -- von Hippel-Lindau disease -- Breast cancer -- Urothelial carcinoma -- Sarcomas -- Gliomas -- Molecular detection of occult tumor cells -- Microarray studies (Beyond histology) -- Acute myeloid leukemia -- Acute lymphoblastic leukemia -- B-cell lymphomas -- T-cell lymphomas -- Lymphoproliferations of immunodeficiency -- Myeloproliferative disorders and myelodysplastic syndromes -- Human immunodeficiency virus type 1 -- Hepatitis B and C viruses -- Viral infections in transplant patients -- Viral infections of the central nervous system -- Sexually transmitted diseases -- Respiratory pathogens -- Bacterial pathogens -- Mycobacterial infections -- Forensic DNA typing -- Parentage and relationship testing -- Assessment of chimerism in the setting of allogenic hematopoietic cell transplantation -- Specimen identification through DNA analysis -- Molecular HLA typing -- Molecular pathology laboratory management -- From research to clinical practice.
  • v. 1-, 2008- Springer
  • 2010 Springer
    Hunt, Jennifer L.
    Molecular oncogenesis -- Systematic autoimmune diseases -- MicroRNAs in endocrine diseases -- Clinical detection and treatment of thyroid diseases -- Autoimmune thyroid diseases -- Benign nodular thyroid disease -- Fine needle aspiration: present and future -- Well-differentiated papillary thyroid carcinoma -- Well-differentiated thyroid follicular carcinoma -- Poorly differentiated and undifferentiated thyroid carcinomas -- Medullary thyroid carcinoma -- Unusual thyroid tumors -- Hematopoietic tumors of the thyroid -- Clinical detection and treatment of parathyroid diseases -- Nonneoplastic parathyroid diseases -- Neoplastic parathyroid diseases -- Clinical detection and treatment of benign and malignant pituitary diseases -- Nonneoplastic and neoplastic pituitary diseases -- Clinical detection and treatment of adrenal disease -- Benign and malignant pheochromocytomas and paragangliomas -- Benign and malignant diseases of the adrenal cortex -- Clinical detection and treatment of pancreatic neuroendocrine tumors -- Pancreatic endocrine neoplasms -- Gastrointestinal neuroendocrine tumors -- Head and neck neuroendocrine tumors -- Merkel cell carcinoma -- Neuroendocrine lung tumors.
  • 2007 Springer
    Bovicelli, Alessandro; Giordano, Antonio; Kurman, Robert J.
  • 2010 Springer
    Dunphy, Cherie H.
    Section I. Molecular Pathology of Hematolymphoid Neoplasms: General Principles -- Molecular Oncogenesis / Aniruddha J. Deshpande, Christian Buske, Leticia Quintanilla-Martinez, and Falko Fend -- Genetic Predispositions for Hematologic and Lymphoid Disorders / Frederick G. Behm -- Prognostic Markers / David Bahler -- Cancer Stem Cells: Potential Targets for Molecular Medicine / Isabel G. Newton and Catriona H.M. Jamieson -- Gene Therapy for Leukemia and Lymphoma / Xiaopei Huang and Yiping Yang -- Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression) / Richard J.Q. McNally -- Viral Oncogenesis / Alexander A. Benders and Margaret L. Gulley -- Section II. Specific Techniques and Their Applications in Molecular Hematopathology -- Techniques to Determine Clonality in Hematolymphoid Malignancies / Daniel E. Sabath -- Techniques to Detect Defining Chromosomal Translocations/Abnormalities / Jennifer J.D. Morrissette, Karen Weck, and Cherie H. Dunphy -- Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease / Marie E. Beckner and Jeffrey A. Kant -- Detection of Resistance to Therapy in Hematolymphoid Neoplasms / Karen Weck -- Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting / Jessica K. Booker -- Gene Expression Profiling / Cherie H. Dunphy -- Proteomics of Human Malignant Lymphoma / Megan S. Lim, Rodney R. Miles, and Kojo S.J. Elenitoba-Johnson -- Mouse Models of Hematolymphoid Malignancies / Krista M.D. La Perle and Suzana S. Couto -- Section III. Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes -- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Patricia Aoun -- Marginal Zone B-Cell Lymphoma / Lynne V. Abruzzo and Rachel L. Sargent -- Lymphoplasmacytic Lymphoma / Pei Lin -- Molecular Pathology of Plasma Cell Neoplasms / James R. Cook -- The Roles of Molecular Techniques in the Diagnosis and Management of Follicular Lymphoma / W. Richard Burack -- Mantle Cell Lymphoma / Kai Fu and Qinglong Hu -- Diffuse Large B-Cell Lymphomas / Cherie H. Dunphy -- The Molecular Pathology of Burkitt Lymphoma / Claudio Mosse and Karen Weck -- Precursor B-Cell Acute Lymphoblastic Leukemia / Julie M. Gastier-Foster -- Molecular Genetics of Mature T/NK Neoplasms / John P. Greer, Utpal P. Davé, Nishitha Reddy, Christine M. Lovly, and Claudio A. Mosse -- Precursor T-Cell Neoplasms / Kim De Keersmaecker and Adolfo Ferrando -- Classical Hodgkin Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma / Michele Roullet and Adam Bagg -- Posttransplant Lymphoproliferative Disorder / Margaret L. Gulley -- AIDS-Related Lymphomas / Amy Chadburn and Ethel Cesarman -- Chronic Myelogenous Leukemia / Dan Jones -- Molecular Pathogenesis of Nonchronic Myeloid Leukemia Myeloproliferative Neoplasms / Mike Perez and Chung-Che (Jeff) Chang -- Molecular Pathology of Myelodysplastic/Myeloproliferative Neoplasms, Myeloid, and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, and FGFR1, and Mastocytosis / Robert P. Hasserjian -- Molecular Pathogenesis of Myelodysplastic Syndromes / Jesalyn J. Taylor and Chung-Che "Jeff" Chang -- Acute Myeloid Leukemias with Recurrent Cytogenetic Abnormalities / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemias with Normal Cytogenetics / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia / Sergej N. Konoplev and Carlos E. Bueso-Ramos -- Molecular Pathology of Hemoglobin and Erythrocyte Membrane Disorders / Murat O. Arcasoy and Patrick G. Gallagher -- White Blood Cell and Immunodeficiency Disorders / John F. Bastian and Michelle Hernandez -- Molecular Basis of Disorders of Hemostasis and Thrombosis / Alice Ma -- Sarcoidosis: Are There Sarcoidosis Genes? / Helmut H. Popper -- Castleman's Disease / Richard Flavin, Cara M. Martin, Orla Sheils, and John James O'Leary -- Molecular Pathology of Histiocytic Disorders / Mihaela Onciu -- Reactive Lymphadenopathies: Molecular Analysis / Dennis P. O'Malley -- Molecular Pathology of Infectious Lymphadenitides / Kristin Fiebelkorn -- Gene Therapy for Nonneoplastic Hematologic and Histiocytic Disorders / Kareem N. Washington, John F. Tisdale, and Matthew M. Hsieh.
  • 2011 Springer
    Monga, Satdarshan P. S.
    Gross and cellular anatomy of the liver -- Liver zonation -- Hepatocytes -- Biliary epithelial cells -- Stellate cells -- Kupffer cells -- Sinusoidal endothelial cells -- Hepatic carbohydrate metabolism -- Hepatic protein metabolism -- Hepatic lipid metabolism -- Detoxification functions of the liver -- Bile acid metabolism -- Liver development -- Transcriptional control of hepatocyte differentiation -- Bile duct development and biliary differentiation -- Hepatic progenitors in development and transplantation -- Adult liver stem cells -- Liver regeneration -- Senescent liver -- Signaling pathways in the liver -- Hepatocyte transplantation -- Hepatic tissue engineering -- Hepatic gene therapy -- Liver cell death -- Macroautophagy -- Hepatic ischemia/reperfusion injury -- Inflammation and liver injury -- Oxidative stress and liver injury -- Fatty liver -- Hepatic fibrosis and cirrhosis -- Biliary cirrhosis -- Cholestasis -- Portal hypertension -- Nonalcoholic fatty liver disease -- Alcoholic liver disease -- Viral hepatitis A -- Viral hepatitis B -- Viral hepatitis C -- Viral hepatitis D -- Viral hepatitis E -- Autoimmune hepatitis -- Toxicant-induced liver injury -- Wilson's disease -- Hemochromatosis -- Glycogen storage diseases -- X1-antitrypsin deficiency -- Hepatic artery diseases -- Hepatic venous outflow obstruction -- Primary biliary cirrhosis -- Primary sclerosing cholangitis -- Biliary atresia -- Benign liver tumors -- Hepatoblastoma -- Hepatocyte growth, proliferation and experimental carcinogenesis -- Stem cells and liver cancer -- Primary hepatocellular carcinoma -- Fibrolamellular hepatocellular carcinoma -- Biology of metastatic liver tumors -- Cholangiocarcinoma -- Neoplasms of extrahepatic bile ducts -- Neoplasms of the gallbladder -- Current and future methods for diagnosis of neoplastic liver disease.
  • 2012 Springer
    Cagle, Philip T.
    Part 1. Molecular Pathology of Lung Cancer: General Principles -- Approach to Personalized Care of the Lung Cancer Patient / Philip T. Cagle -- Etiology of Lung Cancer / Philip T. Cagle -- Genetic Susceptibility to Lung Cancer / Timothy Craig Allen -- Lung Cancer Stem Cells / Timothy Craig Allen -- The Classification of Pre-invasive Lesions / Keith M. Kerr -- Molecular Pathology of Precursor and Pre-invasive Lesions / Keith M. Kerr -- Revised Classification for Adenocarcinoma / Philip T. Cagle and Keith M. Kerr -- Molecular Basis for the Current Lung Cancer Classification / Alain C. Borczuk -- Molecular Diagnosis of Lung Cancer / Lucian R. Chirieac and Philip T. Cagle -- Molecular Targeted Therapy of Lung Cancer / Sanja Dacic -- Molecular Prognostic Markers of Lung Cancer / Sanja Dacic -- New Techniques for Optical and Molecular Visualization of Lung Cancer / Philip T. Cagle -- Part 2. Molecular Pathology of Lung Cancer: Specific Histologic Types -- Adenocarcinoma / Keith M. Kerr -- Squamous Cell Carcinoma / Timothy Craig Allen -- Molecular Pathology of Large Cell Carcinoma / Alain C. Borczuk -- Molecular Pathology of Small Cell Carcinomas / Mary Beth Beasley -- Molecular Biopsy of Neuroendocrine Carcinomas Other Than Small Cell Carcinoma / Mary Beth Beasley -- Molecular Pathology of Uncommon Carcinomas / Alain C. Borczuk -- Biology of Lung Cancer Metastases / Lucian R. Chirieac.
  • 2008 Springer
    Zander, Dani S.
    Section 1. Basic Concepts of Molecular Pathology -- Genes, Gene Products, and Transcription Factors / Philip T. Cagle -- Receptors, Signaling Pathways, Cell Cycle, and DNA Damage Repair / Philip T. Cagle -- Cell Adhesion Molecules / Timothy Craig Allen and Philip T. Cagle -- Apoptosis and Cell Death: Relevance to Lung / Pothana Saikumar and Rekha Kar -- Roles of Mutation and Epimutation in the Development of Lung Disease / William B. Coleman -- Section 2. Techniques and Experimental Systems in Molecular Pathology -- Bioinformatics and Omics / Timothy Craig Allen and Philip T. Cagle -- General Approach to Molecular Pathology / Gregory L. Blakey and Daniel H. Farkas -- Applications of Molecular Tests in Anatomic Pathology / Jennifer L. Hunt and Sanja Dacic -- Polymerase Chain Reaction and Reverse Transcription-Polymerase Chain Reaction / Dwight Oliver -- Array Comparative Genomic Hybridization in Pathology / Reinhard Ullmann -- Loss of Heterozygosity in Lung Diseases / Sharon C. Presnell -- In Situ Hybridization: Principles and Applications for Pulmonary Medicine / Kevin C. Halling and Amy J. Wendel -- Proteomics / Larry Fowler and Wieslaw Furmaga -- Animal Models of Lung Disease / Roberto Barrios -- Tissue Culture Models / Roger A. Vertrees, Thomas Goodwin, Jeffrey M. Jordan and Joseph B. Zwischenberger -- Section 3. Molecular Pathology of Pulmonary and Pleural Neoplasms: General Principles -- Molecular Oncogenesis of Lung Cancer / Arwen A. Stelter and Jingwu Xie -- Genetic Susceptibility / Philip T. Cagle and Timothy Craig Allen -- Prognostic Markers / Anna Sienko, Timothy Craig Allen and Philip T. Cagle -- Pulmonary Angiogenesis in Neoplastic and Nonneoplastic Disorders / Michael P. Keane and Robert M. Strieter -- Lung Cancer Stem Cells / Timothy Craig Allen and Philip T. Cagle -- Gene Therapy Approaches for Lung Cancer / Jack A. Roth -- Response to Conventional Therapy and Targeted Molecular Therapy / Timothy Craig Allen, Anna Sienko and Philip T. Cagle -- Environmental Agents in Lung and Pleural Neoplasms / Steven R. Blumen and Brooke T. Mossman -- Viral Oncogenesis / Cindy Noel Berthelot and Stephen K. Tyring -- Section 4. Molecular Pathology of Pulmonary and Pleural Neoplasms: Specific Histologic Types -- Adenocarcinoma and Its Precursor Lesions / Helmut H. Popper -- Molecular Pathology of Squamous Cell Carcinoma and Its Precursors / Soon-Hee Jung, Bihong Zhao, Li Mao and Jae Y. Ro -- Molecular Pathology of Large Cell Carcinoma and Its Precursors / Jennifer A. Eleazar and Alain C. Borczuk -- Small Cell Carcinoma / Elisabeth Brambilla -- Neuroendocrine Carcinomas and Precursors / Elisabeth Brambilla -- Pulmonary Lymphomas / Candice C. Black, Norman B. Levy and Gregory J. Tsongalis -- Posttransplantation Lymphoproliferative Disorder / Aamir Ehsan and Jennifer L. Herrick -- Unusual Benign and Malignant Neoplasms of Lung: Molecular Pathology / Dongfeng Tan, Guoping Wang and Sadir Alrawi -- Primary Versus Metastatic Cancer: Gene Expression Profiling / Jaishree Jagirdar and Philip T. Cagle -- Diffuse Malignant Mesothelioma: Genetic Pathways and Mechanisms of Oncogenesis of Asbestos and Other Agents That Cause Mesotheliomas / Françoise Galateau-Sallé and Jean Michel Vignaud -- Molecular Pathology of Pediatric Tumors of the Lung / Josefine M. Heim-Hall -- Section 5. Molecular Pathology of Pulmonary Infections -- Basis of Susceptibility to Lung Infection / Frank C. Schmalstieg and Armond S. Goldman -- Molecular Pathology of Viral Respiratory Diseases / Geoffrey A. Land -- Molecular Pathology of Rickettsial Lung Infections / J. Stephen Dumler -- Bacteria / Nabin K. Shrestha and Gary W. Procop -- Immunopathology of Tuberculosis / Jeffrey K. Actor, Robert L. Hunter and Chinnaswamy Jagannath -- Molecular Pathology of Fungal Lung Infection / Michael R. McGinnis, Michael B. Smith and Abida K. Haque -- Parasites / Juan P. Olano -- Section 6. Molecular Pathology of Other Nonneoplastic Pulmonary Diseases: General Principles -- Inflammation / Armando E. Fraire -- Oxidants and Antioxidants / Hanzhong Liu and Gary A. Visner -- Epithelial Repair and Regeneration / Steven L. Brody and Jeffrey J. Atkinson -- Fibrogenesis / John S. Munger and William N. Rom -- Stem Cells in Nonneoplastic Lung Disorders / Dani S. Zander -- Gene Therapy in Nonneoplastic Lung Disease / Timothy Craig Allen and Philip T. Cagle -- Section 7. Molecular Pathology of Other Nonneoplastic Pulmonary Diseases: Specific Entities -- Smoking-Related Lung Diseases / Manuel G. Cosio and Helmut H. Popper -- Heritable α1-Antitrypsin Deficiency / Richard N. Sifers -- Asthma / David B. Corry and Farrah Kheradmand -- Cystic Fibrosis / Annick Clement, Harriet Corvol and Brigitte Fauroux -- Pulmonary Organogenesis and Developmental Abnormalities / Timothy Craig Allen and Philip T. Cagle -- Genetic Abnormalities of Surfactant Metabolism / Lawrence M. Nogee and Susan E. Wert -- Usual Interstitial Pneumonia / Marco Chilosi, Bruno Murer and Venerino Poletti -- Sarcoidosis: Are There Sarcoidosis Genes? / Helmut H. Popper -- Histiocytic Diseases of the Lung / Carol Farver and Tracey L. Bonfield -- Pulmonary Arterial Hypertension / Wim Timens -- Immunopathology of Pulmonary Vasculitides / Steven N. Emancipator, Philip T. Cagle and Abida K. Haque -- Asbestosis and Silicosis / Philip T. Cagle and Timothy Craig Allen.
  • 2013 Springer
    Lynch, John P.; Sepulveda, Antonia R.
    Introduction -- Mechanisms of Gastrointestinal Carcinogenesis /Frank I. Scott, John P. Lynch -- Epithelial Neoplastic Disease -- Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers /Davendra Sohal, Antonia R. Sepulveda, Weijing Sun -- Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma /Mamoun Younes -- Molecular Pathology of Squamous Carcinomas of the Esophagus /Rohinton S. Tarapore, Jonathan P. Katz -- Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers /Shuko Harada, Antonia R. Sepulveda -- Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes /Fátima Carneiro, Carla Oliveira, Raquel Seruca -- Cancer Predisposition Syndromes of the Gastrointestinal Tract /Ian S. Hagemann, Antonia R. Sepulveda -- Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Type /Asif Rashid -- Cancers of the Rectum and Anal Canal /Jenia Jenab-Wolcott, Bruce Giantonio -- Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia /Takeshi Uehara, Deqin Ma, Antonia R. Sepulveda -- Non-Epithelial Neoplastic Tumors -- Molecular Biology and Pathology of Gastrointestinal Stromal Tumors /Paul J. Zhang -- Neuroendocrine Tumors /Joseph R. Pisegna -- Metastatic Disease and Tumor Markers -- Molecular Mechanisms of Tumor Metastasis /Andrew D. Rhim, Davendra Sohal, Hiroshi Nakagawa -- Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis /Loren Joseph -- Serological Markers of Digestive Tract Cancers /Jorge L. Sepulveda.
  • 2015 Springer
    Karajannis, Matthias A.; Zagzag, David.
    This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.
  • 2012 ScienceDirect
    Tanase, Cristiana Pistol; Badiu, Corin; Ogrezeanu, Irina.
    Pituitary tumor classification : functionality, invasiveness, and aggressiveness -- Immunohistochemistry and electron microscopy as evaluation criteria in tumor classification in the deciphering of pituitary adenomas -- Proliferation -- Angiogenesis -- Apoptosis -- Signal transduction -- Stem cell markers in pituitary adenomas -- MicroRNAs -- New generic tools for diagnosis: genomics and proteomics -- Therapeutic approaches: drug, surgical, and radiotherapy.
  • Springer Protocols
    Baker, Harry F.
    What would Thomas Henry Huxley have made of prion diseases? / R.M. Ridley -- Prion protein as copper-binding protein at the synapse / H.A. Kretzschmar [and others] -- A function for the prion protein? / D.R. Brown and I.M. Jones -- Prion protein peptide / D.R. Brown -- Characterization of bovine spongiform encephalopathy and scrapie strains/isolates by immunochemical analysis of PRPSC / M.H. Groschup [and others] -- Differential targeting of neurons by prion strains / S.J. DeArmond -- Transgenic studies of prion diseases / G.C. Telling -- Prions: From neurografts to neuroinvasion / M. Glatzel [and others] -- Cellular and transgenic models of familial prion diseases / D.A. Harris [and others] -- Central nervous system inflammation and prion disease pathogenesis / S. Betmouni and V. Hugh Perry -- The electroneuropathology of prion disease / J. Richard Greene -- Transmissible spongiform encephalopathy neurobiology and ultrastructure suggests extracellular PRPSC conversion consistent with classical amyloidosis / M. Jeffrey and J.R. Fraser -- Conformation as therapeutic target in the prionoses and other neurodegenerative conditions / T. Wisniewski [and others] -- Prions of yeast from cytoplasmic genes to heritable amyloidosis / R.B. Wickner [and others].
  • Springer Protocols
    Killeen, Anthony A.
    DNA extraction from paraffin-embedded tissues / H. Fan and M.L. Gulley -- DNA extraction from fresh or frozen tissues / H. Fan and M.L. Gulley -- RNA extraction from fresh or frozen tissues / H. Fan and M.L. Gulley -- Single-strand conformation polymorphism analysis of mutations in exons 4-8 of the TP53 gene / K.H. Vähäkangas, K. Castrén and J.A. Welsh -- Cleavase fragment length polymorphism analysis for genotyping and mutation detection / L. Heisler and C.-H. Lee -- Detection of telomerase by in situ hybridization and by polymerase chain reaction-based telomerase activity assay / C.P. Morales and S.E. Holt -- Detection of microsatellite instability / K.D. Berg, C.A. Griffin and J.R. Eshleman -- Polymerase chain reaction clonality assays based on x-linked genes / L. Pan and H. Peng -- Fluorescent in situ hybridization / S. Sheldon -- HER-2/neu oncogene amplification determined by fluorescence in situ hybridization / J.S. Ross, C.E. Sheehan and J.A. Fletcher -- A nested reverse transcriptase-polymerase chain reaction assay to detect BCR/abl / L.M. Wasserman -- Detection of t(15;17)(q24;q21), inv(16)/t(16;16)(p13;q22), and t(8;21)(q22;q22) anomalies in acute myeloid leukemias / D.S. Viswanatha -- Detection of t(14; 18)(q32;q21)-associated BCL-2/Jh gene fusion in non-Hodgkin lymphoma / D.S. Viswanatha -- Detection of breast cancer cells using immunomagnetic beads and reverse transcriptase polymerase chain reaction / S. Luke and K.L. Kaul -- Molecular detection of circulating prostate cancer cells / K.L. Kaul -- Methods to detect clonal gene rearrangements in lymphomas and leukemias / N. Mitha and R.C. McGlennen -- Monitoring of bone marrow transplant engraftment / K.P. Woronzoff-Dashkoff and R.C. McGlennen -- Direct molecular diagnosis of multiple endocrine neoplasia type 1 / E.M. Petty, M. Glynn and A.E. Bale -- Molecular detection of multiple endocrine neoplasia type 2 / E.H. Rowsell and M.J. Wick -- Assay for detecting the i1307k susceptibility allele within the adenomatous polyposis coligene / S.B. Gruber -- Detection of human papillomaviruses by polymerase chain reaction and in situ hybridization / E.R. Unger and S.D. Vernon -- Molecular methods for detecting Epstein-Barr virus (part i) / H. Fan and M.L. Gulley -- Molecular methods for detecting Epstein-Barr virus (part ii) / H. Fan and M.L. Gulley -- Molecular methods for detecting Epstein-Barr virus (part iii) / H. Fan and M.L. Gulley -- Molecular detection of Kaposi's sarcoma-associated herpesvirus/ human herpesvirus-8 / E. Cesarman -- Diagnostic applications of quantitative polymerase chain reaction for cytomegalovirus / R.H. Scheuermann and X. Bai -- A colorimetric microtiter plate polymerase chain reaction system that detects herpes simplex virus in cerebrospinal fluid and discriminates genotypes 1 and 2 / Y.-W. Tang -- Detection and typing of hepatitis c virus / F.S. Nolte -- Detection and speciation of mycobacteria in formalin-fixed, paraffin-embedded tissue sections / D. Mohl and T.J. Giordano -- Ultrasensitive quantitation of human immunodeficiency virus type 1 RNA in plasma by the Amplicor and Cobas Amplicor HIV-1 monitor tests / S. Herman, J. Novotny and M. Rosenstraus -- Molecular diagnosis of hereditary thrombotic disorders / J.G. Donnelly -- Prenatal genotyping of the RhD locus to identify fetuses at risk for hemolytic disease of the newborn / M.J. Hessner and D.B. Bellissimo -- Molecular diagnosis of hereditary hemochromatosis / S. Huber and K.V. Voelkerding -- Genotyping of apolipoprotein E / I.C. Ozturk, N. Akel and A.A. Killeen -- Genotyping for functionally important human CYP2D6*4 (B) mutation using TaqMan probes / M.M. Shi [and others].
  • 2003 CRCnetBASE
    Kéri, Gyorgy; Tóth, István.
  • 2013 Springer
    Huang, Luqi.
    "This book reviews the latest developments in pharmacognosy, introduces a series of new views and insights, presents the hotspots and focus of the field of study on molecular pharmacognosy, and predicts a new direction of study on the resource science of TCM. Furthermore, the book also provides an open communications platform for the development of molecular pharmacognosy."--Publisher.
  • 2012
    Rosenberg, Gary A.
    Status: Not Checked OutLane Catalog Record
    Anatomy of fluid interfaces that protect the microenvironment -- Physiology of the cerebrospinal and interstitial fluids -- Neurovascular unit -- Glucose, amino acid and lipid metabolism -- Disorders of cerebrospinal circulation : idiopathic intracranial hypertension (IIH) and hydrocephalus -- Quantification of cerebral blood flow and blood brain barrier transport by NMR and PET -- Mechanisms of ischemic/hypoxic brain injury -- Vascular cognitive impairment and Alzheimer's disease -- Effects of altitude on the brain -- Brain edema -- Intracerebral hemorrhage -- Autoimmunity, hypoxia, and inflammation in demyelinating diseases.
  • 2014 Springer Protocols
    Besse, Pascale.
    Plant Taxonomy: An Historical Perspective, Current Challenges and Perspectives -- Guidelines for the Choice of Sequences for Molecular Plant Taxonomy -- Leaf Tissue Sampling and DNA Extraction Protocols -- DNA Extraction from Herbarium Specimens -- Analysis of Variation in Chloroplast DNA Sequences -- Mitochondrial Genome and Plant Taxonomy -- Nuclear Ribosomal RNA Genes: ITS Region -- New Technologies for Ultra-High Throughput Genotyping in Plant Taxonomy -- Development of Microsatellite Enriched Libraries -- Randomly Amplified Polymorphic DNA (RAPD) and Derived Techniques -- Multilocus Profiling with AFLP, ISSR and SAMPL -- Transposon Based Tagging: IRAP, REMAP and iPBS -- Phylogenetic Reconstruction Methods: An Overview -- The Application of Flow Cytometry for Estimating Genome Size and Ploidy Level in Plants -- Molecular Cytogenetics (FISH and Flurochrome Banding): Resolving Species Relationships and Genome Organisation -- GISH: Resolving Interspecific and Intergeneric Hybrids -- On the Relevance of Molecular Tools for the Taxonomy Revision in Malvales, Malvaceae s.l. and Dombeyoideae -- What Has Molecular Systematics Contributed to Our Knowledge of the Plant Family Proteaceae.
  • 2012 Springer Protocols
    Espina, Virginia; Liotta, L. A.
    Tumor staging and grading: A primer -- Clinical trial design in the age of molecular profiling -- Personalized medicine: ethics for clinical trials -- Reduction of preanalytical variability in specimen procurement for molecular profiling -- The human side of cancer biobanking -- Introduction to genomics -- Genomic profiling: cDNA arrays and oligoarrays -- Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples -- An overview of microRNA methods: expression profiling and target identification -- Antibody validation by western blotting -- Laser capture microdissection: Arcturus(XT) infrared capture and UV cutting methods -- Antibody microarrays: Analysis of cystic fibrosis -- Tissue microarrays as a tool in the discovery and validation of predictive biomarkers -- Reverse-phase protein microarrays -- Serum low-molecular-weight protein fractionation for biomarker discovery -- Mass spectrometry-based biomarker discovery -- Mitochondrial proteome: toward the detection and profiling of disease associated alterations -- Adult neural stem cells: Isolation and propagation -- Evanescent-wave field imaging: An introduction to total internal reflection fluorescence microscopy -- Construction and hyperspectral imaging of quantum dot lysate arrays -- Microarray data analysis: Comparing two population means -- Bioinformatics/biostatistics: microarray analysis -- Structure-based functional design of drugs: From target to lead compound -- Personalized medicine: Changing the paradigm of drug development -- Grant writing tips for translational research -- Inventions and patents: a practical tutorial -- Regulatory approval pathways for molecular diagnostic technology -- Small business development for molecular diagnostics.
  • 2000 ScienceDirect
    Denomme, Gregory A.; Reid, Marion E.; Rios, Maria.
  • 2012
    Andrews, Logan Dane; Chen, James; Herschlag, Daniel; Wandless, Thomas.
    Chemical transfer of the phosphoryl group is perhaps the most critical and pervasive reaction in biology, and the enzymes that catalyze these reactions provide some of the largest reaction rate enhancements known. Phosphoryl transfer enzymes have evolved active sites with a remarkable ability to recognize and distinguish similar substrates and transient species along the reaction pathway. A full understanding of the physical features and recognition strategies used by these active sites is lacking and remains as a critical obstacle to the design of novel enzymes for applications in health and industry. All enzymes must provide preferential stabilization to reaction transition states while limiting binding to ground state substrates and products. Alkaline Phosphatase (AP) is one of Nature's most impressive examples, as it prefers stabilizing the phosphoryl group transition state by 10^22-fold compared to its modest binding of the phosphate monoester substrate in the ground state. Binding studies were carried out with a set of highly similar ground state molecules to probe this tremendous molecular discrimination. The results showed that despite the similarities of these molecules, AP has a very strong preference for binding inorganic phosphate (Pi). A vibrational spectroscopy approach was used to dissect the atomic details of Pi binding to AP. These measurements in addition to pH-dependent binding studies suggest that a proton from Pi is transferred to AP upon binding allowing it to bind more strongly than related molecules that lack a transferrable proton. It was proposed that the proton transfer neutralizes electrostatic repulsion between the anionic active site nucleophile of AP and the negatively charged oxygen atoms of the bound ligand. This model implicated a role for anionic active site nucleophiles, when left deprotonated, in destabilizing ground state binding and contributing to the enzyme's enormous preferential stabilization of the transition state. This previously unknown role for anionic nucleophiles was tested further using mutagenesis studies and binding affinity comparisons in AP and another phosphatase. The results provide new insights into how anionic nucleophiles of phosphoryl transfer enzymes contribute to catalysis.
  • 2007 Springer
    Wang, Donna H.
    Contributors -- Part 1. The DEG/ENaC family -- 1. The role of DEG/ENaC ion channels in sensory mechanotransduction / Dafni Bazopoulou, Giannis Voglis, and Nektarios Tavernarakis -- 2. ASICs function as cardiac lactic acid sensors during myocardial ischemia / Christopher J. Benson and Edwin W. McCleskey -- 3. Molecular components of neural sensory transduction DEG/ENac proteins in baro and chemoreceptors / François M. Abboud, Yongjun Lu, and Mark W. Chapleau -- Part II. The TRP family -- 4. TRP channels as molecular sensors of physical stimuli / Roger G. O'Neill -- 5. TRPV1 in central cardiovascular control : discerning the C-fiber afferent pathway / Michael C. Andersen, Mark W. Doyle, Timothy W. Bailey, and Young-Ho Jin -- 6. TRPV1 as a molecular transducer for salt and water homeostasis / Donna H. Wang and Jeffrey R. Sachs -- 7. Functional interaction between ATP and TRPV1 receptors / Makoto Tominaga and Tomoko Moriyama -- 8. TRPV4 and hypotonic stress / David M. Cohen -- Part III. Other ion channels and biosensors -- 9. Ion channels in shear stress sensing in vascular endothelium : ion channels in vascular mechanotransduction / Abdul I. Barakat, Deborah K. Lieu, and Andrea Gojova -- 10. Redox signaling in oxygen sensing by vessels / Andrea Olschewski and E. Kenneth Weir -- 11. Impedance spectroscopy and quartz crystal microbalance : noninvasive tools to analyze ligand-receptor interactions at functionalized surfaces and of cell monolayers / Andreas Hinz and Hans-Joachim Galla -- Index.
  • 2010
    Parameswaran, Poornima; Fire, Andrew Z.; Glenn, Jeffrey S.; Kay, Mark A.; Kirkegaard, Karla; Singh, Upinder.
    Small RNAs that are 19-30 nucleotides in length use the genetic information encoded in their sequence to effect gene regulation in a sequence-directed manner. Infections with RNA viruses in plants, worms and flies generate short viral-derived RNAs ("vsRNAs") that map to the genome of the infecting virus. The regulated production of these vsRNAs and their engagement by the immune apparatus is essential for inhibiting viral growth, making vsRNAs important components of antiviral immunity in these organisms. RNA virus-derived vsRNA-mediated gene silencing is yet to be demonstrated in mammalian systems. We investigated diverse RNA virus-mammalian systems, and characterized changes in small RNA populations that occur during viral infection in animal cells using high-throughput sequencing. Due to the large number of samples to be analyzed, we designed DNA barcodes to 'tag' RNA samples from individual experiments, which facilitated sequencing in parallel from multiple samples. Our work demonstrated the generality of RNA virus-derived vsRNA production, and the ability of the cellular short RNA apparatus to engage these vsRNAs in worms during Flock House Virus replication, and in mammalian cells during infections with Hepatitis C, Polio, Dengue, Vesicular Stomatitis or West Nile virus. In addition to the appearance of vsRNAs during infection, we saw a number of specific changes in host-encoded small RNA (miRNA) profiles. For several infection models investigated in more detail, the RNAi and Interferon pathways modulated the abundance of vsRNAs. We found evidence for populations of vsRNAs that exist as duplexed small interfering RNAs ("siRNAs; " effectors of gene silencing) with zero to three nucleotide 3' overhangs. We also observed strand-selective loading of siRNAs onto Argonaute complexes, which are mediators of gene silencing. We quantitated the capacity of these HCVrep-derived vsRNAs to down-regulate target mRNAs in a sequence-specific manner in mammalian systems. We found that abundant HCVrep vsRNAs are not capable of mediating robust silencing (i.e. 2-fold or higher) of Luciferase reporters that have been engineered with vsRNA targets. Additionally, over-expression of siRNAs corresponding to five abundant vsRNAs failed to enhance silencing of Hepatitis C Virus mRNA. These results complement each other and suggest that in mammalian hosts, the virus may coexist with an abundant population of vsRNAs. Questions still remain as to whether robust gene silencing may be achieved by the cooperative action of abundant vsRNAs, or if abundant vsRNAs specifically inhibited from functioning in gene silencing, or alternatively, if they have novel roles in pathways distinct from gene silencing.
  • 2013 Springer
    Cheng, Liang; Eble, John N.
    Molecular Pathology of Colorectal Cancer / Fred T. Bosman -- Molecular Pathology of Pancreatic Cancer / Laura D. Wood, N. Volkan Adsay and Ralph H. Hruban -- Molecular Pathology of Liver Tumors / Thomas Longerich, Kai Breuhahn and Peter Schirmacher -- Molecular Pathology of Gallbladder Cancer / Juan Carlos Roa and N. Volkan Adsay -- Molecular Pathology of Lung Cancers / Lynette M. Sholl and Neal I. Lindeman -- Molecular Pathology of Breast Cancer / Alejandro Ariel Gru and Donald Craig Allred -- Molecular Pathology of Ovarian Cancer / Kruti P. Maniar, Ie-Ming Shih and Robert J. Kurman -- Molecular Pathology of Endometrial Cancer / Xavier Matias-Guiu and Jaime Prat -- Molecular Pathology of Kidney Tumors / Sean R. Williamson, John N. Eble and Liang Cheng -- Molecular Pathology of Prostate Cancer / Bora Gurel, Riley E. Alexander, Liang Cheng and Angelo M. De Marzo -- Molecular Pathology of Urinary Bladder Cancer / George J. Netto and Liang Cheng -- Molecular Pathology of Testicular Cancer / Katharina Biermann and Leendert H. J. Looijenga -- Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer / Andrea Saggini and Boris Bastian -- Molecular Pathology of Head and Neck Cancer / Audrey P. Calzada, Maie A. St. John, Elliot Abemayor and David T. W. Wong -- Molecular Pathology of Soft Tissue and Bone Tumors / Neal I. Lindeman and Paola Dal Cin -- Molecular Pathology of the Central Nervous System / Brent T. Harris and Eyas M. Hattab -- Molecular Pathology of Endocrine Cancer / Ricardo V. Lloyd, Long Jin, Darya Buehler, Heather Hardin and Weihua Shan.
  • 2001 Wiley
    Feringa, Ben L.
    ch. 1. Approaches to a molecular switch using photoinduced electron and energy transfer -- ch. 2. Photoswitchable molcular systems based on diarylethenes -- ch. 3. Optoelectronic molecular switches based on dihydroazulene-Vinylheptafulvene (DHA0VHF) -- ch. 4. Molecular switches with photochromic fulgides -- ch. 5. Chiroptical molecular switches -- ch. 6. Photochemical biomolecular switches: the route to optobioelectronics -- ch. 7. Switchable catenanes and molecular shuttles -- ch. 8. Metallo-rotaxanes and catenanes as redox switches : towards molecular machines and motors -- ch. 9. Switchable molecular receptors and recognition processes : from photoresponsive crown ethers to allosteric sugar sensing systems -- ch. 10. Multistate/multifunctional molecular-level systems : photochromic flavylium compounds -- ch. 11. Molecular logic systems -- ch. 12. Liquid crystal photonics : opto-photochemical effects in photoresponsive liquid crystals -- ch. 13. Photoswitchable polypeptides.
  • 2008 Springer
    Antman, Karen; Kaufman, Howard L.; Wadler, Scott.
  • 2007 Springer
    Aggarwal, Bharat B.; Shishodia, Shishir; Surh, Young-Joon.
    Also available: Print – 2007
  • 2014 Springer
    Jothy, Serge; Yousef, George M.
    Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers. Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.
  • 2011 ScienceDirect
    Foxman, Betsy.
    The application of modern molecular genetic and biologic techniques to infectious disease epidemiology dramatically improves measurement of disease and putative risk factors increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. We examine these opportunities and methodologic challenges giving specific examples. The book will be written for the reader with limited understanding of genetics, biology and epidemiology. *Presents the key points of consideration when integrating molecular biology and epidemiology *Discusses how using molecular tools in epidemiologic research affects program design and conduct *Considers the ethical concerns that arise in molecular epidemiologic studies *Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field.
  • 2006
    Josephy, P. David; Mannervik, Bengt.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer Protocols
    Grant, Stephen G.; Keohavong, Phouthone.
    Array-Based Immunoassays with Rolling-Circle Amplification Detection -- Analysis of Protein Changes Using Two-Dimensional Difference Gel Electrophoresis -- Assessment of Pathological and Physiological Changes in Mouse Lung Through Bronchoalveolar Lavage -- Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex System -- Detection of DNA Methylation by MeDIP and MBDCap Assays: An Overview of Techniques -- Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR) -- Strategies for Measurement of Biotransformation Enzyme Gene Expression -- Genotyping Technologies: Application to Biotransformation Enzyme Genetic Polymorphism Screening -- TaqMan Fluorogenic Detection System to Analyze Gene Transcription in Autopsy Material -- 32P-Postlabeling Analysis of DNA Adducts -- Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot -- DNA Isolation and Sample Preparation for Quantification of Adduct Levels by Accelerator Mass Spectrometry -- Analysis of DNA Strand Cleavage at Abasic Sites -- Premature Chromosome Condensation in Human Resting Peripheral Blood Lymphocytes Without Mitogen Stimulation for Chromosome Aberration Analysis Using Specific Whole Chromosome DNA Hybridization Probes -- Mutagen Sensitivity as Measured by Induced Chromatid Breakage as a Marker of Cancer Risk -- Pulsed-Field Gel Electrophoresis Analysis of Multicellular DNA Double-Strand Break Damage and Repair -- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice -- The Blood-Based Glycophorin A (GPA) Human In Vivo Somatic Mutation Assay -- Flow Cytometric Quantification of Mutant T Cells with Altered Expression of the T-Cell Receptor: Detecting Somatic Mutants in Humans and Mice -- Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes. (Continued) -- Quantifying In Vivo Somatic Mutations Using Transgenic Mouse Model Systems -- The Human T-Cell Cloning Assay: Identifying Genotypes Susceptible to Drug Toxicity and Somatic Mutation -- Molecular Analysis of Mutations in the Human HPRT Gene -- Simultaneous Quantification of t(14; 18) and HPRT Exon 2/3 Deletions in Human Lymphocytes -- Mutation Screening of the TP53 Gene by Temporal Temperature Gel Electrophoresis (TTGE) -- Detection of Point Mutations of K-ras Oncogene and p53 Tumor-Suppressor Gene in Sputum Samples -- ACB-PCR Quantification of Somatic Oncomutation -- Gel-Based Nonradioactive Single-Strand Conformational Polymorphism and Mutation Detection: Limitations and Solutions -- Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions -- Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells -- The Sister Chromatid Exchange (SCE) Assay -- The Gene Cluster Instability (GCI) Assay for Recombination -- Measuring Recombination Proficiency in Mouse Embryonic Stem Cells -- Microsatellite Instability: An Indirect Assay to Detect Defects in the Cellular Mismatch Repair Machinery -- Unscheduled DNA Synthesis: The Clinical and Functional Assay for Global Genomic DNA Nucleotide Excision Repair -- Analysis of Actively Transcribed DNA Repair Using a Transfection-Based System -- An Immunoassay for Measuring Repair of UV Photoproducts -- Analysis of Double-Strand Break Repair by Nonhomologous DNA End Joining in Cell-Free Extracts from Mammalian Cells -- Bioenergetic Analysis of Intact Mammalian Cells Using the Seahorse XF24 Extracellular Flux Analyzer and a Luciferase ATP Assay -- Quantification of Selective Phosphatidylserine Oxidation During Apoptosis -- Quantitative Method of Measuring Phosphatidylserine Externalization During Apoptosis Using Electron Paramagnetic Resonance (EPR) Spectroscopy and Annexin-Conjugated Iron -- Detection of Programmed Cell Death in Cells Exposed to Genotoxic Agents Using a Caspase Activation Assay.
  • 2013 Springer
    De Filippis, Ivano; McKee, Marian L.
    Part 1. General consideration on microorganism typing methods -- Molecular Epidemiology / Amy E. Seitz and D. Rebecca Prevots -- Part 2. Gastrointestinal Pathogens -- Enterococcus / Lúcia Martins Teixeira and Vânia Lúcia Carreira Merquior -- Listeria monocytogenes / Todd J. Ward -- Enterobacteriaceae / Steven L. Foley, Aaron M. Lynne and Rajesh Nayak -- Molecular Typing of Vibrio cholerae: Imprints in the Epidemiology of Cholera / T. Ramamurthy, A. K. Mukhopadhyay, R. K. Nandy and G. Balakrish Nair -- Molecular Typing of Clostridium difficile / Andrej Weintraub and Carl Erik Nord -- Oral and Intestinal Bacteroidetes / Marina C. Claros and Georg Conrads -- Part 3. Oral and Respiratory Pathogens -- Streptococci / Lesley McGee and Bernard Beall -- Molecular Typing of Streptococcus mutans / Kazuhiko Nakano, Ichiro Nakagawa, Satu Alaluusua and Takashi Ooshima -- Genotyping of Periodontal Anaerobic Bacteria in Relationship to Pathogenesis / Masae Kuboniwa and Atsuo Amano -- Molecular Typing of Nontuberculous Mycobacteria / Jakko van Ingen and Dick van Soolingen -- Molecular Typing of Neisseria meningitidis / Muhamed-Kheir Taha and Ala-Eddine Deghmane -- Molecular Typing in Bacterial Infections Haemophilus spp. / Marina Cerquetti -- Moraxella / Nevada M. Pingault and Thomas V. Riley -- Legionella pneumophila Typing / Christophe Ginevra -- Mycoplasma and Ureaplasma / Ken B. Waites, Li Xiao, Vanya Paralanov, Rose M. Viscardi and John I. Glass -- Corynebacterium diphtheriae / Igor Mokrousov -- Burkholderia / Pavel Drevinek and Eshwar Mahenthiralingam -- Part 4. Urogenital Pathogens -- Treponema / Allan Pillay -- Chlamydiaceae / Troy Skwor and Deborah Dean -- Part 5. Vector borne Pathogens -- Borreliae / Dionysios Liveris, Klára Hanincová and Ira Schwartz -- Erysipelothrix / Yumiko Imada -- Part 6. Pathogens causing Healthcare-Associated Infection -- Staphylococci / Jodi A. Lindsay -- Molecular Typing Methods for the Genus Pseudomonas / Balázs Libisch -- Part 7. Emerging and Reemerging Pathogens -- Acinetobacter baumannii / Lenie Dijkshoorn -- Molecular Typing of Coxiella burnetii: A Review of Available Methods with Major Focus on PCR-Based Techniques / V. Boldis, E. Spitalska and R. Toman.
  • 2013 Springer
    Giese, Matthias.
    This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer.
  • 2014 Springer
    Giese, Matthias.
    This title discusses all aspects of non-infectious and non-cancer -- so called NINC -- vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. Practical perspectives of patentability of vaccines are discussed. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.
  • 2013 Springer
    Modrow, Susanne.
    The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.
  • 2012 Future Med
    Rosell Costa, R.
    Integrating molecular knowledge in clinical decision-making for personalized cancer management -- Gastrointestinal stromal tumors -- Metastatic melanoma -- Ovarian cancer -- Triple-negative breast cancer -- Gastric cancer -- Pleural mesothelioma -- Lung adenocarcinoma.
  • 2010 Springer
    Arceci, Robert; Houghton, Peter J.
    Part 1. Hematologic Malignancies -- The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia / William L. Carroll and Rob Pieters -- Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia / Alejandro Gutierrez and A. Thomas Look -- Molecularly Targeted Therapy for Infant ALL / Patrick A. Brown and Carolyn A. Felix -- Targeted Therapeutic Approaches for AML / Robert J. Arceci and Donald Small -- Acute Promyelocytic Leukaemia / Andrea Biondi, Anna Maria Testi and Brenda E. S. Gibson -- Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy / Jeffrey W. Taub, Yubin Ge and Yaddanapudi Ravindranath -- Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML) / Jennifer O'Hara Lauchle and Benjamin S. Braun -- Chronic Myeloid Leukemia: Pathophysiology and Therapeutics / Seth J. Corey and Jorge Cortes -- Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes / Lia Gore -- New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma / Megan S. Lim and Mitchell S. Cairo -- Molecular Targeting of Post-transplant Lymphoproliferative Disorders / Michael Wang and Thomas G. Gross -- Part 2. Solid Tumors -- Molecularly Targeted Therapies for Astrocytomas / Ian F. Pollack -- Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer / Yoon-Jae Cho and Scott L. Pomeroy -- Future Treatments of Ependymoma / Richard J. Gilbertson -- Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INI1/hSNF5 Tumor Suppressor / Ganjam V. Kalpana and Melissa E. Smith -- Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors / Brigitte Widemann -- Molecular Therapy for Neuroblastoma / Yaël P. Mossé and John M. Maris -- Ewing's Sarcoma Family of Tumors: Molecular Targets Need Arrows / Jeffrey A. Toretsky and Aykut Üren -- Molecular Targeted Therapy for Wilms' Tumor / James I. Geller and Jeffrey S. Dome -- Molecular Therapy for Rhabdomyosarcoma / Raushan T. Kurmasheva, Hajime Hosoi, Ken Kikuchi and Peter J. Houghton -- Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here? / Rosanna Ricafort and Richard Gorlick -- Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology / Stephen X. Skapek.
  • 2013
    Kuriyan, John; Konforti, Boyana B.; Wemmer, David E.
    Status: Not Checked OutLane Catalog Record
    "Key to making future advances in the areas of biochemistry and molecular medicine is a new generation of molecular biologists and biochemists who are able to harness the tools and insights of physics and chemistry to exploit the emergence of genomic and systems-level information in biology.The basic ideas of energy, entropy, equilibrium thermodynamics, transport processes and reaction kinetics are closely related to exciting issues in contemporary biology, such as protein folding, chaperones and prion diseases, DNA polymerase and ribosome fidelity, DNA recognition, drug design, signal transduction, ion channel function, motor protein action and the versatility of enzyme mechanism." ... "Molecules of Life" ... deepens our understanding of how life functions by illuminating the physical principles underpinning biological phenomena." --Excerpts from publisher notes.
  • 2014 Wiley
    Klein, Harvey G.; Anstee, David J.; Mollison, P. L.
    "Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field"--Provided by publisher.
  • 2002 CRCnetBASE
    Sigel, Astrid; Sigel, Helmut.
  • 2006
    Mahar, Maggie.
    Status: Not Checked OutLane Catalog Record
    1. The road to corporate medicine -- 2. The cost of competition : an overview -- 3. For-profit hospitals : a flaw in the business model? -- 4. Not-for-profit hospitals : "no margin, no mission"? -- 5. When more care is not better care -- 6. "Too little, too late" : the cost of rationing care -- 7. Doing less and doing it right : is pay for performance the answer? -- 8. Device makers, drugmakers, and the FDA -- Where we are now : everyone out of the pool.
  • 2007
    Freeman, Melvyn; Funk, Michelle.
    Status: Not Checked OutLane Catalog Record
  • 2009
    Bailey, Patsy; Fortney, Judith; Lobis, Samantha; Maine, Deborah.
    Status: Not Checked OutLane Catalog Record
    "The original targets for these Goals were a two-thirds reduction in the mortality of children under 5 and a three-quarters reduction in the maternal mortality ratio between 1990 and 2015. There is worldwide consensus that, in order to reach these targets, good-quality essential services must be integrated into strong health systems. The addition in 2007 of a new target in Goal 5--universal access to reproductive health by 2015--reinforces this consensus: all people should have access to essential maternal, newborn, child and reproductive health services provided in a continuum of care. In order to reduce maternal mortality, Emergency Obstetric Care (EmOC) must be available and accessible to all women. While all aspects of reproductive health care including family planning and delivery with the help of a skilled health professional also plays an important role in reducing maternal and neonatal mortality, this handbook focuses on the critical role of EmOC in saving the lives of women with obstetric complications during pregnancy and childbirth and saving the lives of newborns intrapartum. The handbook describes indicators that can be used to assess, monitor and evaluate the availability, use and quality of EmOC." - p. vi This handbook describes indicators that can be used to assess, monitor and evaluate the availability, use and quality of Emergency Obstetric Care. These emergency obstetric care indicators can be used to measure progress in a programmatic continuum: from the availability of and access to emergency obstetric care to the use and quality of those services.
  • 2010 WHO
    Also available: Print – 2010
  • 2011
    Egeler, Emily Lawson; Ferrell, James Ellsworth; Kopito, Ron; Wandless, Thomas.
    Cellular maintenance of protein homeostasis , or proper protein folding, is essential for normal cellular function. Accumulation of misfolded protein can lead to disease and even cell death. The ubiquitin-proteasome system plays a central role in processing cellular proteins for degradation, but little is currently known about how misfolded cytosolic proteins are recognized by protein quality control machinery and targeted for degradation in mammalian cells. In the work presented here, we work with a model protein substrate that is unstable when expressed in cells, but stabilized by addition of a small cell-permeable ligand. Using purified protein, we show that unstable mutants are poorly folded or rapidly sampling unfolded states. The propensity to unfold in vitro correlates with observed instability when expressed in cells. We also show that these substrates are rapidly ubiquitinated en route to degradation at the proteasome in a ligand-dependent manner. We conducted a mass spectrometry screen to identify endogenous protein interactors with the model substrate, which identified a few annotated ubiquitin-proteasome system components. The findings presented herein correlate observed cellular instability to both the propensity of the protein to unfold and the extent of ubiquitination in the ligand-free state. We propose that this protein is a ligand-dependent substrate for the protein quality control machinery, providing an excellent substrate into further query the mechanisms of protein quality control.
  • 2013 ClinicalKey
    Kofke, W. Andrew; Le Roux, Peter D.; Levine, Joshua M.
    Ideal for neurosurgeons, neurologists, neuroanesthesiologists, and intensivists, this book helps you use the latest technology to more successfully detect deteriorations in neurological status in the ICU. This neurosurgery reference offers in-depth coverage of state-of-the-art management strategies and techniques so you can effectively monitor your patients and ensure the best outcomes.
  • 2008 Springer
    Cold, G. E.; Juul, Niels.
  • 2014 Springer
    Cannesson, Maxime; Ehrenfeld, Jesse M.
    This is an introduction to the patient monitoring technologies that are used in today's acute care environments, including the operating room, recovery room, emergency department, intensive care unit, and telemetry floor. To a significant extent, day-to-day medical decision-making relies on the information provided by these technologies, yet how they actually work is not always addressed during education and training. The editors and contributors are world-renowned experts who specialize in developing, refining, and testing the technology that makes modern-day clinical monitoring possible. Their aim in creating the book is to bridge the gap between clinical training and clinical practice with an easy to use and up-to-date guide. ·How monitoring works in a variety of acute care settings ·For any healthcare professional working in an acute care environment ·How to apply theoretical knowledge to real patient situations ·Hemodynamic, respiratory, neuro-, metabolic, and other forms of monitoring ·Information technologies in the acute care setting ·New and future technologies.
  • 2012 Wiley
    Jevon, Philip; Ewens, Beverley; Pooni, J. S.
    Recognition & management of the deteriorating patient -- Assessment of the critically ill patient -- Monitoring respiratory function -- Monitoring cardiovascular function 1 : ECG monitoring -- Monitoring cardiovascular function 2 haemodynamic monitoring -- Monitoring neurological function -- Monitoring renal function -- Monitoring gastrointestinal function -- Monitoring hepatic function -- Monitoring endocrine function -- Monitoring nutritional status -- Monitoring temperature -- Monitoring pain -- Monitoring a patient receiving a blood transfusion -- Monitoring the patient with infection and related systemic inflammatory response -- Monitoring the critically ill, pregnant patient -- Monitoring the critically ill child -- Monitoring during transport -- Record keeping.
  • 2012 Springer
    Koht, Antoun; Sloan, Tod B.; Toleikis, J. Richard.
    Part I. Techniques of Monitoring -- Chapter 1. Somatosensory Evoked Potentials -- Chapter 2. Transcranial Motor Evoked Potentials -- Chapter 3. Auditory Evoked Potentials -- Chapter 4. VEP -- Chapter 5. Deep Brain Stimulation -- Chapter 6. Spinal Cord Stimulation Techniques -- Chapter 7. Electromyography -- Chapter 8. Cortical Mapping -- Chapter 10. Near-Infrared Spectroscopy -- Chapter 11. Transcranial Doppler -- Chapter 12. Jugular Bulb Monitoring -- Chapter 13. Monitoring Intracranial Pressure -- Part II. Anesthesia Considerations -- Chapter 14. Anesthesia for Awake Neurosurgery -- Chapter 15. General Anesthesia for Monitoring -- Chapter 16. Monitoring Anesthetic Effect -- Part III. Case-Based Presentations -- Chapter 17. Monitoring Applications and Evaluating Changes, Algorithm -- Chapter 18. Intracranial Aneurysm Clipping -- Chapter 19. Intracranial AVM Surgery -- Chapter 20. Surgery for Supratentorial Mass -- Chapter 21. Surgery for Infratentorial Mass -- Chapter 22. Microvascular Surgery for Trigeminal Neuralgia -- Chapter 23. Surgery for Hemifacial Spasm -- Chapter 24. Skull Base Surgery -- Chapter 25. Surgery for Arnold Chiari Malformation -- Chapter 26. ENT and Anterior Neck Surgery -- Chapter 27. Carotid Surgery -- Chapter 28. Anterior Cervical Spine Surgery -- Chapter 29. Posterior Cervical Spine Surgery -- Chapter 30. Surgery for Scoliosis Correction -- Chapter 31. Surgery on the Thoracic Spine -- Chapter 32. Surgery in the Lumbo-Sacral Spine -- Chapter 33. Intramedullary Spinal Cord Surgery -- Chapter 34. Surgery for Tethered Cord -- Chapter 35. Surgery in the Peripheral Nervous System -- Chapter 36. Surgery of the Aortic Arch -- Chapter 37. Surgery on Thoraco-Abdominal Aneurysms -- Chapter 38. Monitoring During Cardiopulmonary Bypass -- Chapter 39. Interventional Neuroradiology -- Part IV. Intensive Care Monitoring -- Chapter 40. Monitoring in Intensive Care -- Chapter 41. Monitoring Cerebral Blood Flood -- Afterword. Future of Monitoring the Nervous System.
  • 2007
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Atzori, Marco; Tseng, Kuei-Yuan.
  • 2013 Future Med
    Uckun, Fatih M.
    Monoclonal antibodies in contemporary cancer therapy / Fatih M. Uckun -- mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment / Letizia Polito, Rossella Mancuso, Daniele Mercatelli, Massimo Bortolotti & Andrea Bolognesi -- mAbs targeting CTLA-4 and clinical outcomes / Francesco Spagnolo, Virginia Picasso & Paola Queirolo -- mAbs targeting VEGF/VEGFR and clinical outcomes in cancer treatment / Brendan Curley, Michael Newton & Jame Abraham -- mAbs targeting RANKL in bone metastasis treatment / Bérengère Gobin, Marc Baud'Huin, Bertrand Isidor, Dominique Heymann & Marie-Françoise Heymann -- Novel mAb-based therapies for leukemia / Osmond J. D'Cruz & Fatih M. Uckun -- Index.
  • 2014 Springer Protocols
    Fischer, Nicolas; Ossipow, Vincent.
    Antigen production for monoclonal antibody generation / Giovanni Magistrelli and Pauline Malinge -- Method for the generation of antibodies specific for site and posttranslational modifications / Hidemasa Goto and Masaki Inagaki -- Immunization, hybridoma generation, and selection for monoclonal antibody production / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo -- Hybridoma technology for the generation of rodent mAbs via classical fusion / Efthalia Chronopoulou [and three others] -- Generation of rabbit monoclonal antibodies / Pi-Chen Yam and Katherine L. Knight -- Screening hybridomas for cell surface antigens by high-throughput homogeneous assay and flow cytometry / Alejandro Uribe-Benninghoff [and four others] -- Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker / Suba Dharshanan and Cheah Swee Hung -- Design and generation of synthetic antibody libraries for phage display / Gang Chen and Sachdev S. Sidhu -- Selection and screening using antibody phage display libraries / Patrick Koenig and Germaine Fuh -- Yeast surface display for antibody isolation : library construction, library screening, and affinity maturation / James A.Van Deventer and Karl Dane Wittrup -- Human B cell immortalization for monoclonal antibody production / Joyce Hui-Yuen, Siva Koganti, and Sumita Bhaduri-McIntosh -- Using next-generation sequencing for discovery of high- frequency monoclonal antibodies in the variable gene repertoires from immunized mice / Ulrike Haessler and Sai T. Reddy -- Cloning, reformatting, and small-scale expression of monoclonal antibody isolated from mouse, rat, or hamster hybridoma / Jeremy Loyau and François Rousseau -- Cloning of recombinant monoclonal antibodies from hybridomas in a single mammalian expression plasmid / Nicole Müller-Sienerth [and three others] -- Monoclonal antibody purification by ceramic hydroxyapatite chromatography / Larry J. Cummings, Russell G. Frost, and Mark A. Snyder -- Rapid purification of monoclonal antibodies using magnetic microspheres / Pauline Malinge and Giovanni Magistrelli -- Generation of cell lines for monoclonal antibody production / Krista Alvin and Jianxin Ye -- Expression and purification of recombinant antibody formats and antibody fusion proteins / Martin Siegemund [and four others] -- Purification of antibodies and antibody fragments using CaptureSelect [trademark] affinity resins / Pim Hermans, Hendrik Adams, and Frank Detmers -- Reformatting of scFv antibodies into the scFv-Fc format and their downstream purification / Emil Bujak [and three others] -- Antibody V and C domain sequence, structure, and interaction analysis with special reference to IMGT® / Eltaf Alamyar [and three others] -- Measuring antibody affinities as well as the active concentration of antigens present on a cell surface / Palaniswami Rathanaswami -- Determination of antibody structures / Robyn L. Stanfield -- Affinity maturation of monoclonal antibodies by multi-site- directed mutagenesis / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo -- Epitope mapping with membrane-bound synthetic overlapping peptides / Terumi Midoro-Horiuti and Randall M. Goldblum -- Epitope mapping by epitope excision, hydrogen/deuterium exchange, and peptide-panning techniques combined with in silico analysis/ Nicola Clementi [and five others] -- Fine epitope mapping based on phage display and extensive mutagenesis of the target antigen / Gertrudis Rojas -- Epitope mapping with random phage display library / Terumi Midoro-Horiuti and Randall M. Goldblum -- Epitope mapping of monoclonal and polyclonal antibodies using bacterial cell surface display / Anna-Luisa Volk, Francis Jingxin Hu, and Johan Rockberg -- Ion exchange-high-performance liquid chromatography (IEX-HPLC) / Marie Corbier, Delphine Schrag, and Sylvain Raimondi -- Size exclusion-high-performance liquid chromatography (SEC-HPLC) / Delphine Schrag, Marie Corbier, and Sylvain Raimondi -- N-glycosylation characterization by liquid chromatography with mass spectrometry / Song Klapoetke -- Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization / Stefanie Derer [and six others] -- Labeling and use of monoclonal antibodies in immunofluorescence : protocols for cytoskeletal and nuclear antigens / Christoph R. Bauer -- Generation and use of antibody fragments for structural studies of proteins refractory to crystallization / Stephen J. Stahl, Norman R. Watts, and Paul T. Wingfield -- Antibody array generation and use / Carl A.K. Borrebaeck and Christer Wingren.
  • 2007. Springer Protocols
    Albitar, Maher.
  • 2013 Future Med
    Vermorken, Jan B.
    Monoclonal antibodies targeting EGFR/HER2 and clinical outcomes in cancer treatment / Jan B. Vermorken -- Colorectal cancer / Christian Rolfo, Giuseppe Bronte, Antonio Russo & Marc Peeters -- Breast cancer / Sevilay Altintas -- Lung cancer and genitourinary cancers / Dirk Schrijvers -- Tumors of the skin, the CNS and the head and neck / Pol Specenier -- Gynecologic cancers / Jan B. Vermorken -- Index.
  • 2014 Wellcome Trust
    Jones, Emma M.; Tansey, E. M.
  • 2012 Karger
    De León, Diva D.; Stanley, Charles A.
    Historical perspective on the genetic forms of congenital hyperinsulinism / Stanley, C.A., Matschinsky, F.M. -- Biochemistry and physiology of the ATP-sensitive potassium channel / Remedi, M.S., Nichols, C.G. -- Pathophysiology of diffuse ATP-sensitive potassium hyperinsulinism / De León, D.D., Stanley, C.A. -- Molecular defects of ATP-sensitive potassium channels in congenital hyperinsulinism / Shyng, S.-L. ... [et al.] -- Molecular mechanisms and clinical pathophysiologies of focal ATP-sensitive potassium hyperinsulinism and Beckwith-Wiedemann Syndrome / Arnoux, J.-B. ... [et al.] -- Pancreatic histopathology of hyperinsulinism / Suchi, M., Bhatti, T.R., Ruchelli, E.D. -- Localization of a focal lesion of congenital hyperinsulinism : imaging and surgery / States, L.J., Adzick, N.S. -- Role of incretin hormones in hyperinsulinemic hypoglycemia / De León, D.D. -- Glutamate dehydrogenase : structure, regulation, and its role in insulin homeostasis / Smith, T.J. -- Congenital hyperinsulinism due to activating mutations of glutamate dehydrogenase : the hyperinsulinism/hyperammonemia syndrome / Kelly, A., Palladino, A., Stanley, C.A. -- Amino acid-stimulated insulin secretion : the role of the glutamine-glutamate-alpha-ketoglutarate axis / Li, C., Matschinsky, F.M., Stanley, C.A. -- Tissue specificity of glutamate dehydrogenase as illustrated in pancreatic beta-cells and the central nervous system / Carobbio, S. ... [et al.] -- The molecular genetics and pathophysiology of congenital hyperinsulinism caused by short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency / Molven, A. ... [et al.] -- Hyperinsulinism due to activating mutations of glucokinase / Sayed, S., Matschinsky, F., Stanley, C.A. -- Hyperinsulinism due to mutations of uncoupling protein 2 / Del Mar Gonzalez-Barroso, M., de Lonlay, P., Ricquier, D. -- Exercise-induced hyperinsulinism : a failure of monocarboxylate transporter 1 expression silencing / Otonkoski, T., Meissner, T. -- HNF4A and hyperinsulinemic hypoglycemia / Kapoor, R.R., James, C.T., Hussain, K.
  • 2006 Springer
    Foissner, Wilhelm; Xu, Kuidong.
    vol. 1. Protospathidiidae, Arcuospathidiidae, Apertospathulidae --
  • 2006 Springer
    Berger, Helmut.
  • 2015 Springer
    Bandiera, Stelvio M.; Hrycay, Eugene G.
    Foreword -- 1. Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes -- 2. Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants -- 3. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions -- 4. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1 -- 5. Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples With Single Substrates -- 6. Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and their Role in Cardiovascular Disease -- 7. Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s -- 8. Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates,- 9. Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources -- 10. Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs -- 11. Biological Diversity of Cytochrome P450 Redox Partner Proteins -- 12. Cytochrome P450cin (CYP176A1) -- 13. Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins that Combine Peroxidase and Cytochrome P450 Properties.
    Also available: Print – 2015
  • 2013 Springer
    Douard, John; Schultz, Pamela D.
    The metaphor of the monster or predator usually a sexual predator, drug dealer in areas frequented by children, or psychopathic murderer is a powerful framing device in public discourse about how the criminal justice system should respond to serious violent crimes. The cultural history of the monster reveals significant features of the metaphor that raise questions about the extent to which justice can be achieved in both the punishment of what are regarded as ""monstrous crimes"" and the treatment of those who commit such crimes. This book is the first to address the connections between the ...
  • 2008 ClinicalKey
    Reid, Mont; Stehr, Wolfgang.
    Also available: Print – 2008
  • 2013 CRCnetBASE
    King, Michael A.; Ljungberg, Michael; Strand, Sven-Erik.
    "Preface Monte Carlo methods have become an important tool for exploring complicated systems and especially for investigation of imaging parameters in nuclear medicine. By using sampling methods based on probability distribution function in combination with methods that simulate the various particle interaction that can occur, a detailed radiation transport can be simulated from the patient into the imaging system. Monte Carlo simulation does not replace experimental measurements but offers a unique possibility to gain understanding in the underlying physics phenomena that form nuclear medicine images. It also provides a substantial help to researchers to develop methods for image improvement. When combining an accurate model of the imaging system and a realistic model of the patient's geometry and activity distribution, the simulated images can be highly clinically realistic and almost undistinguishable from a real patient measurement. The first edition of this book was published in 1998. It was one of the first books that combined a description of the Monte Carlo methods and principles with relevant Monte Carlo programs and applications in the field of diagnostic nuclear medicine. It is now 14 years since that publication and we therefore felt that it was important to have a second edition since new and very powerful Monte Carlo programs and methods have become available. This new edition provides the background to, and a summary of, the current Monte Carlo techniques that are in use today. The focus is still on the diagnostic imaging application but several programs that are described in the book also allow for charge-particle simulations applicable to dosimetryrelated applications"-- Provided by publisher.
  • 2011 CRCnetBASE
    Chang, Mark.
    "Preface Drug development, aiming at improving people's health, becomes more costly every year. The pharmaceutical industry must join its efforts with government and health professions to seek new, innovative, and cost- effective approaches in the development process. During this evolutionary process in the next decades, computer simulations will no doubt play a critical role. Computer simulation or Monte Carlo is the technique of simulating a dynamic system or process using a computer program. Computer simulations, as an efficient and effective research tool, have been used virtually in every concern of engineering, science, mathematics, etc. In this book, I am going to present the concept, theory, algorithm, and cases studies of Monte Carlo simulation in the pharmaceutical and health industries. The concepts refer not only to simulation in general, but also to various types of simulations in drug development. The theory will include virtual data sampling, game theory, deterministic and stochastic decision theories, adaptive design methods, Petrinet, genetic programming, resampling methods, and other strategies. These theories and methods either are necessary to carry out the simulations or make the simulations more efficient, even though there are many practical problems that can be simulated directly in ad hoc fashion without any theory of their efficiency or convergence considerations. The algorithms, which can be descriptive, computer pseudocode, or a combination of both, provide the basis for implementation of simulation methods. The case studies or applications are the simplified versions of the real world problems. These simplifications are necessary because a single case could otherwise occupy the whole book, preventing readers from exploring broad issues"--Provided by publisher.
  • v.1-2=, 2009, 2011 Springer Protocols
    v.2 (2011) Springer Protocols
    Gould, Todd D.
  • 2013 Springer
    Henderson, Brian.
  • 2009 Springer
    Hanson, Stephen S.
    Justifying moral claims in a pluralistic society -- Engelhardt and the content-free (?) principle of permission -- Four-principles approach: an appeal to the common morality for resolution and justification -- Casuistry in a pluralistic society -- Moral acquaintanceships as a means of the conflict resolution.
  • 2009 Springer
    Braeckman, Johan; De Schrijver, Jelle; Vanneste, Sven; Verplaetse, Jan.
    The immoral brain / Andrea L. Glenn and Adrian Raine -- "Extended attachment" and the human brain : internalized cultural values and evolutionary implications / Jorge Moll and Ricardo de Oliveira-Souza -- Neuro-cognitive systems involved in moral reasoning / James Blair -- Empathy and morality : integrating social and neuroscience approaches / Jean Decety and C. Daniel Batson -- Moral judgment and the brain : a functional approach to the question of emotion and cognition in moral judgment integrating psychology, neuroscience and evolutionary biology / Kristin Prehn and Hauke R. Heekeren -- Moral dysfunction : theoretical model and potential neurosurgical treatments / Dirk De Ridder ... [et al.] -- Does it pay to be good? Competing evolutionary explanations of pro-social behaviour / Matthijs van Veelen -- How can evolution and neuroscience help us understand moral capacities? / Randolph M. Nesse -- Runaway soical selection for displays of partner value and altruism / Randolph M. Nesse -- The evolved brain : understanding religious ethics and religious violence / John Teehan -- An evolutionary and cognitive neuroscience perspective on moral modularity / Jelle De Schrijver.
  • 2011
  • 2006 Springer
    Betta, Michela.
    From destiny to freedom? : on human nature and liberal eugenics in the age of genetic manipulation / Michela Betta -- Diagnostic knowledge in the genetic economy and commerce / Michela Betta -- Body talk : genetic screening as a device of crime regulation / Richard Hil, Richard Hindmarsh -- Genetic testing and human genetic databases / Astrid H. Gesche -- The imperative of the "new genetics" : challenges for ethics, law, and social policy / David Weisbrot -- Insurance and genetics : regulating a private market in the public interest / David Weisbrot, Brian Opeskin -- The social imperative for community genetic screening : an Australian perspective / MaryAnne Aitken, Sylvia Metcalfe -- Genetically transformed healthcare : healthy children and parents / Enzo A. Palombo, Mrinal Bhave -- The Australian law reform inquiry into genetic commission testing - a worker's perspective / Susan Pennicuik -- Genetic information and the Australian labour movement / Suzanne Jamieson -- Protecting the vulnerable : genetic testing and screening for parentage, immigration, and aboriginality / Astrid H. Gesche -- Essentially whose? : genetic testing and the ownership of genetic information / Lyn Turney -- Self-knowledge and self-care in the age of genetic manipulation / Michela Betta.
  • 2005 ScienceDirect
    Edelstein, Wolfgang; Nunner-Winkler, Gertrud.
    The meaning of moral ought / Jürgen Habermas -- Between Aristotle and Kant : sketch of a morality of recognition / Axel Honneth -- Contexts of recognition : comments on Axel Honneth's moral perspective beyond Aristotle and Kant / Micha Brumlik -- Emotions and the origins of morality / Martha C. Nussbaum -- What should count as moral behavior? The nature of "early morality" in children's development / Augusto Blasi -- Discourse in context / Vilhjálmur Árnason -- Moral intimacy and moral judgment : tailoring general theories to personal contexts / Bill Puka -- Moral resilience : the unhappy moralist / Fritz K. Oser and Roland Reichenbach -- Do concepts matter? The impact of a justice framing on responses to a moral dilemma : a research note / Rainer Döbert and Natalie Juranek -- The discontents and contents in cultural practices : it depends on where you sit / Elliot Turiel -- Changes in moral understanding : an intergenerational comparison / Gertrud Nunner-Winkler -- Is community compatible with autonomy? Cultural ideals versus empirical realities / Joan G. Miller -- Is community compatible with autonomy? Some comments to Joan Miller's research on differing moralities in India and the United States / Lothar Krappmann -- Reasoning about moral obligations and interpersonal responsibilities in different cultural contexts / Monika Keller ... [et al.] -- Partiality and identity : psychological research on preferential behavior toward group members / Mordecai Nisan -- Culture, context, and the psychological sources of human rights concepts / Larry Nucci -- To forgive and forget / Avishai Margalit.
  • 2015 Springer
    Prager, Gerhard; Widhalm, Kurt.
    As the worldwide prevalence of morbid obesity among adolescents continues to rise, recent years have seen a large increase in the performance of adolescent bariatric surgery. While surgical intervention often becomes necessary when conservative weight-loss therapies have failed, no standards regarding the post-operative regimen and long-term management of adolescent patients have been established. Thus, the treatment of obesity and its co-morbidities requires a multidisciplinary approach, taking into account epidemiological, clinical, nutritional, and genetic aspects of morbid obesity in the pediatric age group. This volume discusses both conventional therapy and surgical options for morbid obesity in the pediatric age group. In the first part, obesity-related diseases, genetics, and psychological factors are analyzed. The second part focuses on current bariatric surgery procedures, including dietary restrictions and guidelines to prevent nutritional deficiencies common after surgery. Therefore, the book will prove an invaluable resource for pediatricians, surgeons, nutritionists, dieticians, and all other health professionals who treat adolescent obesity.
  • 2007 Karger
    Simopoulos, Artemis P.; Visioli, F.
    Modified Cretan Mediterranean diet in the prevention of coronary heart disease and cancer: an update / de Lorgeril, M., Salen, P. -- Endothelial nitric oxide synthase as a mediator of the positive health effects of Mediterranean diets and wine against metabolic syndrome / Leighton, F., Urquiaga, I. -- Effects of an omega-3-enriched Mediterranean diet (modified diet of Crete) versus a Swedish diet / Friberg, P., Johansson, M. -- Dietary fat intake of European countries in the Mediterranean area: an update / Marangoni, F., Martiello, A., Galli, C. -- The Mediterranean diet in Italy: an update / Rubba, P. ... [et al.] -- A Mediterranean diet is not enough for health: physical fitness is an important additional contributor to health for the adults of tomorrow / Castillo-Garzón, M.J. ... [et al.] -- Mediterranean diet in the Maghreb: an update / Zeghichi-Hamri, S., Kallithraka, S. -- Antioxidants in the Mediterranean diets: an update / Bogani, P., Visioli, F. -- Olive oil / Boskou, D. -- Melatonin in edible plants (phytomelatonin): identification, concentrations, bioavailability and proposed functions / Reiter, R.J. ... [et al.].
  • 2010
    Naam, Ramez.
    Status: Not Checked OutLane Catalog Record
    Introduction. Healing and enhancing -- 1. Designer bodies -- 2. Designer minds -- 3. Created equal -- 4. Methuselah's genes -- 5. Designer lifespans -- 8. Methuselah's world -- 7. A child of one's own -- 8. Designer children -- 9. The wired brain -- 10. World wide mind -- 11. Life without limits.
  • 2013 (5th ed.) AccessMedicine
    Butterworth, John F.; Mackey, David C.; Mikhail, Maged S.; Morgan, G. Edward; Wasnick, John D.
    Also available: Print – <2013>
  • 2010 CRCnetBASE
    Conroy, David.
    Why the investigation was started -- Materials and methodology -- Evidence not recorded on videotape -- The phenomenon of the disappearing hair follicles -- Particles entering the eyes -- Particles exiting the eyes -- A substance that transverses the optic globe -- The irregular iris -- Particles that exit the feet -- Particles that enter the feet -- The microorganism mobility : an internal propulsion system -- Green feet illuminate the role of the epidermis in the life-cycle of the microorganism -- Coated hairs under the microscope -- The micro organism possibly growing on a piece of cocaine -- A summary of the observations -- The structure of the microorganism -- A model accounting for the observed phenomena -- Is there a cure? -- Future considerations : a microorganism as an etiology for delusional parasitosis.
  • 2013 Springer
    Parat, Marie-Odile.
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • 2012 Springer
    Ribatti, Domenico.
    Introduction -- Morphological aspects of tumor vasculature -- Mechanisms of control of angiogenesis in tumor vasculature -- Anti-Angiogenesis and vascular targeting in tumor vasculature.
  • 2012 Springer
    Di Pietro, Antonio; Pérez-Martín, José.
    This book combines state-of-the-art expertise from a variety of diverse pathogen model systems to provide an update to our current understanding of the regulation of fungal morphogenesis as a key determinant of pathogenicity in fungi.
  • 2010 Springer
    Alibardi, Lorenzo.
  • 2014 Springer
    Nomura, Yasuya.
    This book approaches inner ear diseases from a perspective that is as multifaceted as the diseases themselves. Common among these disorders are sudden deafness, Mnires disease, and perilymphatic fistula. With an awareness of the generally insufficient understanding of the causes and etiologies of these and other inner ear diseases, the author helps to fill those gaps in knowledge. Several factors have impeded a clearer understanding of inner ear diseases, chiefly the small size of the organ and its location in the hard temporal bone and, consequently, the inadequate resolution of CT and MRI images for pathophysiological analysis. This book provides morphological information about the inner ear, elucidating its fluids and blood vessels to help familiarize the reader with the complicated inner ear structures. Important information about how the inner ear responds to various stimuli is also given for a better understanding of the characteristics of the organ. Included are chapters describing specific diseases and animal models of the diseases. Examples and illustrations are presented for surgical applications. For instance, patients with intractable vertigo of inner-ear origin require surgical treatment and the application of a laser to the vestibular labyrinth, described in detail. With its generous use of color photographs, this book is an excellent reference text for all doctors and trainees in the field of otolaryngology.
  • 2005 Springer
    Bartolomaeus, T.; Purschke, G.
  • 2002 CRCnetBASE
    Forey, Peter L.; MacLeod, Norman.
  • 2012 Springer
    Kaul, Sunil; Wadhwa, Renu.
    Part 1. Structure and Function of Mortalin / Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer / Renu Wadhwa and Sunil C. Kaul -- Mortalin's Machinery / Custer C. Deocaris, Sunil C. Kaul and Renu Wadhwa -- The Role of Mortalin in Iron Homeostasis / Wen-I Luo and James A. Cowan -- Functional Characteristics of Mortalin / Walter A. Baseler, Tara L. Croston and John M. Hollander -- Part 2. Mortalin in Evolution2 Deocaris / Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis / Marie Le Pécheur, Geneviève Morrow and Robert M. Tanguay -- Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes / Charles W. Walker, Ben Low and S. Anne Böttger -- Mortalin and Stem Cells: A Study from Planarians / Renata Batistoni -- Part 3. Mortalin in Health and Disease / Mortalin in Cell Protection from Immune Attack / Moran Saar, Oren Moskovich and Zvi Fishelson -- Mortalin in Neurological Diseases / Jinghua Jin, Jing Zhang, Travis J. Cook and Jake G. Hoekstra -- Loss of Mortalin Function in Parkinson's Disease-Supporting the Mitochondrial Pathway of Neurodegeneration / Lena F. Burbulla and Rejko Krüger -- Hsp75/mortalin and Protection from Ischemic Brain Injury / Robin E. White, Yi-Bing Ouyang and Rona G. Giffard -- Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders / Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa and Ram K. Mishra -- Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis / Alberto J. L. Macario, Francesco Cappello and Everly Conway de Macario -- Part 4. Mortalin and Cancer / Many Faces of Mortalin and Tid1 / Ohad Iosefson and Abdussalam Azem -- Mortalin: A Positive Regulator of Centrosome Duplication and Amplification / Masayuki Kanai and Kenji Fukasawa -- Mortalin Expression in Normal and Neoplastic Tissues / Angheliki Nomikos, Sinclair R. Dundas and Graeme I. Murray -- Mortalin-p53 Interaction as a Target for Liver Cancer Therapy / Wen-Jing Lu, Nikki P. Lee, Renu Wadhwa and John M. Luk -- Mortalin Targeting Gadgets for Cancer Therapy / Chae-Ok Yun and Renu Wadhwa -- Part 5. Mortalin Based Technologies / Cell Internalizing Anti-Mortalin Antibody for Generation of Illuminating MSCs for Long-Term In vitro and In vivo Tracking / Toshimasa Uemura, Masanori Nishi, Sunil C. Kaul and Renu Wadhwa -- Mortalin Staining Pattern as a Reporter for Cell Based Anti-Cancer Drug Screening / Ran Gao, Zeenia Kaul, Tomoko Yaguchi and Renu Wadhwa -- Cell Internalizing Anti-mortalin Antibody as a Nanocarrier / Zeenia Kaul, Tomoko Yaguchi, Renu Wadhwa and Sunil C. Kaul.
  • 2007 Springer
    Kalter, Harold.
    pt. 1. Congenital cardiovascular malformations.
  • 2001
  • 2012
    Hitchens, Christopher.
    "Courageous, insightful and candid thoughts on malady and mortality from one of our most celebrated writers"--Provided by the publisher.
  • Hoyert, Donna L.
    Also available: Print – 1996
  • 2003 HighWire
    Jennings, Garry.
    Also available: Print – 2003
  • 2014 Springer
    Happle, R.
    Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devotedto the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
  • 2007
    Graham-Brown, R. A. C.; Bourke, John F.
    Status: Not Checked OutLane Catalog Record
  • 2009
    Nugent, Patricia Mary; Pelikan, Phyllis K.; Saxton, Dolores F.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Nugent, Patricia Mary; Pelikan, Phyllis K.; Saxton, Dolores F.
    Status: Not Checked OutLane Catalog Record
  • 2014 ClinicalKey
    Jeske, Arthur H.
    Ideal for chairside use by the entire dental team, Mosby's Dental Drug Reference, 11th Edition, provides the current, concise, dental-specific drug information you need at the point of care. More than 850 drug monographs make it easy to find indications and dosages, contraindications, interactions, side effects, serious reactions, and dental considerations. A companion website adds regular drug updates, a full-color pill atlas, printable patient education handouts, reference tables, and more. More than 850 drug monographs offer the vital dental-specific drug information you need.Drug information with relevant patient and family education guidelines in each monograph emphasize oral health, prevention, and treatment from the dental hygiene perspective.Durable and pocket sized, a succinct and organized format makes this guide ideal for chairside use. Bulleted lists provide quick and easy access to general and specific dental-related information in each monograph. .Primers on therapeutic management of common diseases and on medically compromised patients offer key foundational information relevant to the treatment of all patients.New monographs, FDA updates, a color pill atlas, images of common pathologic conditions, patient education handouts, quick-reference guides, and more are available online to help keep this guide compact and user-friendly.
  • 2009
    Pagana, Kathleen Deska; Pagana, Timothy James.
    Status: Not Checked OutLane Catalog Record
  • 2007
    Pagana, Kathleen Deska; Pagana, Timothy James.
    Status: Not Checked OutLane Catalog Record
  • 2002-07.
    Status: Not Checked OutLane Catalog Record
  • 2013 ScienceDirect
    Section 1. Overview and occupational therapy process -- section 2. Occupational performance and the performance areas : evaluation and intervention -- section 3. Performance skills and client factors : evaluation and intervention -- section 4. The occupational therapy process : implementation of interventions -- section 5. Intervention applications.
  • 2011
    Seidel, Henry M.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Ball, Jane; Benedict, G. William; Dains, Joyce E.; Seidel, Henry M.
    Status: Not Checked OutLane Catalog Record
    The History and interviewing process -- Cultural awareness -- Examination techniques and equipment -- Mental status -- Growth and measurement -- Nutrition -- Assessment of pain -- Skin, hair, and nails -- Lymphatic system -- Head and neck -- Eyes -- Ears, nose, and throat -- Chest and lungs -- Heart -- Blood vessels -- Breasts and axillae -- Abdomen -- Female genitalia -- Male genitalia -- Anus, rectum, and prostate -- Musculoskeletal system -- Neurologic system -- Sports participation and evaluation -- Putting it all together -- Taking the next steps: critical thinking -- Recording information -- Emergency or life-threatening situations.
  • 2010
    Cairo, Jimmy M.; Pilbeam, Susan P.
    Status: Not Checked OutLane Catalog Record
  • 2008 Springer
    Silver, John B.; Service, M. W.
    Designing a mosquito sampling programme -- Sampling the egg population -- Sampling the larval population -- Sampling the emerging adult population -- Sampling the adult resting population -- Sampling adults by animal bait catches and by animal-baited traps -- Blood-feeding and its epidemiological significance -- Sampling adults with non-attractant traps -- Sampling adults with light-traps -- Sampling adults with carbon dioxide traps -- Sampling adults with visual attraction traps, sound traps, and other miscellaneous attraction traps -- Estimation of the mortalities of the immature stages -- Methods of age-grading adults and estimation of adult survival rates -- Estimating the size of the adult population -- Measuring adult dispersal -- Experimental hut techniques -- Indices of association and species diversity indices.
  • 2013 Springer
    Das, Bina Pani.
    Japanese Encephalitis (JE), a mosquito borne disease, is the leading cause of viral encephalitis in 14 Asian countries due to its epidemic potential, high case fatality rate and increased possibility of lifelong disability in patients who recover from this dreadful disease. In spite of seriousness of the disease, still only few books are available for ready reference. Hence, this book will be useful for students, entomologists, paramedical staff and vector control managers in public health.Of the thousand suspected JE deaths in India annually, more than 75% is contributed by Northern India wherein disease transmission failed to be explained based on entomological evidence due to inadequate mosquito surveillance tool used in determining JE vector density. In order to overcome the above problem, Dr Bina Pani Das, the author of this book, developed "BPD hop cage method", a simple, cost effective, and operationally feasible surveillance tool specially designed to capture predominantly day resting adult Cx. tritaeniorhynchus mosquitoes, the principal JE vector species in the country from land and aquatic vegetation.
  • 2013 Ovid
    Allen, Hugh D.; Moss, Arthur J.
    "Established since 1968 as a classic pediatric cardiology text, this edition uses new technology to bring the most sought after information in the most concise, effective manner. This eighth edition is reduced from the two-volume work into a concise, easy-to-use single volume moving all but key references to the online component. Leading international experts describe state-of-the-art diagnostic and interventional techniques for treatment of young patients with congenital and acquired heart diseases and for adult survivors of congenital heart disease"-- Provided by publisher.
  • 2008 Ovid
    Adams, Forrest H.; Allen, Hugh D.; Moss, Arthur J.
    v. 1. Structure and function of the cardiovascular system ; Diagnostic methods ; Electrophysiology ; Therapeutic methods ; Pediatric cardiac intensive care ; From the gene to the neonate ; Congenital cardiovascular malformations -- v. 2. Congenital cardiovascular malformations [cont'd.] ; Diseases of the endocardium, myocardium, and pericardium ; Pulmonary vascular disease ; The young adult with congenital heart disease ; Other special problems and issues.
    Also available: Print – v. 1-2., 2008
  • Cambridge
  • 2007
    Emery, Alan E. H.; Emery, Marcia L. H.
    Status: Not Checked OutLane Catalog Record
  • 2011 Springer
    Westall, Carolyn; Liamputtong, Pranee.
    This book fills the gap in knowledge of cultural and social issues relating to pregnancy, childbirth, and motherhood. The book is based on a study which explored how women and their partners in Melbourne, Australia, understood and resolved postnatal depression (PND). The central argument was the significance of support before and after the birth for women's emotional well-being. Thirty-three women who experienced PND were individually interviewed, and eighteen partners were either individually interviewed or attended a focus group. Women were asked to draw their experience of PND and its resolution; these drawings were powerful representations of their lived experience and are included in this book. The book highlights the struggles women faced and the amount of support they received from health professionals, family and friends before and after the birth. The partners provided valuable insights about the support they provided to women, their understanding of PND, as well as their own emotional well-being after the birth. This book offers much more than previous books: it provides the stories of both the women and their partners and a research method (drawings) that is new in the health and social sciences.The insights presented in this book can be used to inform and develop programs to identify women who are particularly vulnerable to experiencing PND, or to improve the treatment of the illness to assist other families in their recovery.
  • 2014 Springer
    Barber, Mary E.; Benders-Hadi, Nikole.
    Despite the importance of regaining social roles during recovery from mental illness, the intersection between motherhood and serious mental illness is often overlooked. This book aims to rectify that neglect. A series of introductory chapters describing current research and services available to mothers with serious mental illness are followed by personal accounts of clients reflecting on their parenting experiences. One goal of the book is to provide clinicians with information on this seldom addressed topic, which they can then use to help patients who are struggling with questions and barriers in their attempts to parent. The inclusion of personal accounts of mothers on issues such as stigma, fears, and discrimination in the context of parenting with a mental illness is intended to promote the message of mental illness recovery to a larger audience as well. Finally, it is hoped that this handbook will help inspire more research on mothers with mental illness and the creation of more services tailored to their needs.
  • 2008 ClinicalKey
    Yue, James J.
    New motion-preserving devices are revolutionizing spine surgery, but the learning curve for these operations is steep, and great attention must be given to patient and device selection and the perfect execution of each procedure. In this text, global leaders in this area discuss the advantages and disadvantages of the full range of non-fusion technologies and present the step-by-step, richly illustrated operative guidance needed to achieve optimal outcomes. Three hours of surgical video on DVD demonstrate how to perform key procedures.
  • 2008 Springer
    Willis-Esqueda, Cynthia.
    Introduction: motivational aspects of prejudice and racism / Cynthia Willis-Esqueda -- Social cognition, ethnic identity, and ethnic specific strategies for coping with threat due to prejudice and discrimination / Amado M. Padilla -- New directions in adversive racism research: persistence and pervasiveness / John F. Dovidio and Samuel L. Gaertner -- The role of race and racial prejudice in recognizing other people / John C. Brigham -- Addressing contemporary racism: the common ingroup identity model / Samuel L. Gaertner and John F. Dovidio.
  • 2009 Springer
    Bevins, Rick A.; Caggiula, Anthony R.
    This title draws upon research on the drug widely believed to form the basis of tobacco use and dependence, nicotine. When discussing drug addiction and dependence, an increasing number of scientists are using the concepts of motivation and related constructs and their applications in modifying behavior.
  • 2011
    Teichmann, Hannah Margareta; Dolmetsch, Ricardo E.; Luo, Liqun; Nelson, W. J.; Shen, Kang.
    Nervous system function, from sensory perception to motor control and cognition, requires the correct wiring of neural circuits during development. The establishment of these circuits consists of the growth and guidance of signal-sending axons and signal-receiving dendrites to their correct targets. Despite being exposed to the same molecular environment, a neuron's axon and dendrites have different morphologies and targets. Using the C. elegans DA9 motoneuron we explore mechanisms of dendrite growth and how a dendrite-specific response is achieved to a cue regulating axons and dendrites. We found that DA9 dendrite development is spatially and temporally distinct from the axon. While the axon grows embryonically, the dendrite develops postembryonically. Characterizing DA9 dendrite growth in larvae, adults and body size mutants suggests that it is not driven by size, but rather by a local cue. A candidate approach to identify this cue taught us that the guidance cue UNC-6/Netrin is required for both axon and dendrite development in DA9. The UNC-6 repulsive receptor UNC-5 repels the axon from the ventral nerve cord, while the attractive receptor UNC-40 is dendritically enriched and promotes antero-posterior dendrite growth. While ventrally secreted UNC-6 instructs axon guidance, dorsal or even membrane-tethered UNC-6 can support dendrite development. Surprisingly, the kinase PAR-4/LKB1 is selectively required for UNC-40 signaling in dendrite outgrowth. Finally, we found that the C-terminal motor kinesin KLP-16 also promotes DA9 dendrite growth and that its enrichment at the DA9 dendrite distal tip may be partially regulated by PAR-4/LKB1. These data suggest that axon and dendrite of one neuron interpret common environmental cues with different receptors and downstream signaling pathways.
  • 2006 Springer
    Latash, Mark L.; Lestienne, Francis.
  • 2005 CRCnetBASE
    Riehle, Alexa; Vaadia, Eilon.
  • 2001 CRCnetBASE
    Cope, Timothy C.
  • 2015
    Bromberg, M. B.
    Status: Not Checked OutLane Catalog Record
    Introduction to motor neuron disease -- History of the recognition of motor neuron disease -- Nomenclature & classification of motor neuron disease -- Clinical anatomy, physiology and pathology of motor neuron disease -- Clinical features of motor neuron disease -- Frontotemporal dysfunction and dementia in amyotrophic lateral sclerosis -- Laboratory tests for motor neuron disease -- Biomarkers for motor neuron disease -- Imaging in motor neuron disease -- Diagnostic criteria for motor neuron disease -- Differential diagnosis of motor neuron disease -- Motor neuron disease progression -- Epidemiology of amyotrophic lateral sclerosis -- Genetics of amyotrophic lateral sclerosis and frontotemporal dementia -- Genome-wide approaches to identify amyotrophic lateral sclerosis-associated genes -- Pathology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration -- Convergence and divergence in amyotrophic lateral sclerosis syndrome: genetics, molecular pathways and molecular mechanisms: -- Immunologic aspects of amyotrophic lateral sclerosis -- Cyanobacteria, amyotrophic lateral sclerosis, and the BMAA hypothesis -- Animal models of adult motor neuron disease -- Multidisciplinary clinics and practice parameters and guidelines -- Allied health and other providers -- Respiratory assessment and management -- Nutritional assessment and management -- Communication assessment and management -- Psychological and psychiatric assessment and management -- Symptoms and management -- Intimacy, sexuality and pregnancy -- Quality of life -- Caregiver issues -- End of life care -- Costs of amyotrophic lateral sclerosis care -- Clinical trial designs in amyotrophic lateral sclerosis -- Stem cell therapy for motor neuron disease.
  • 2007 ScienceDirect
    Eisen, Andrew; Shaw, Pamela J.
    Also available: Print – 2007
  • 2009
    Bromberg, M. B.
    Motor unit number estimations (MUNEs): past, present, and future -- Change in excitability of motor axons modifies statistical MUNE results -- Biological basis for motor unit number estimation through Bayesian statistical analysis of the stimulus-response curve -- Bayesian analysis of the stimulus-response curve -- Results of Bayesian statistical analysis in normal and ALS subjects -- CMAP scan -- Physiological considerations, harware and software requirements for stimulating single motor nerve fibers -- Improving the accuracy of the multiple point stimulation technique -- Incremental stimulation MUNE: automation with global path search and alternation pattern recognition -- Motor unit estimation with high-densit surface EMG: principles and implications -- Decomposition-enhanced spike triggered averaging MUNE: validity, reliability, and impact of contraction force -- Motor unit number estimation in the upper trapezius muscle -- Statistical motor unit number estimation and ALS trials: the effect of motor unit instability -- Motor neuron disorders: novel electrophysiologic approach (MUFDEC protocol) -- Motor unit number estimation (MUNE) in diseases of the motor neuron: utility and comparative analysis in a multimodal biomarker study -- Motor unit number estimation in asymptomatic familial amyotrophic lateral sclerosis -- Detection of pre-clinical motor unit loss in familial amyotrophic lateral sclerosis -- Motor unit number estimates, quantitative motor unit analysis and clinical outcome measures in amyotrophic lateral sclerosis -- Reduction in the motor unit number estimate (MUNE) after cerebral infarction -- Prospective 15-year study of neuromuscular function in a cohort of patients with prior poliomyelitis -- Recent MUNE studies in animal models of motor neuron disease -- Development and use of the incremental twitch subtraction MUNE method in mice -- Issues and expectations for EMG decomposition -- Challenges in computerized MUAP analysis -- Decision support for QEMG -- Optimizing and standardizing quantitative EMG -- Comparison of three quantitative motor unit analysis algorithms -- Cloud interference pattern analysis (IPA) in thoracic paraspinal muscles in motor neuron disease -- Anal sphincter motor unit potential (MUP) differences between sides, between rest and voluntary contraction, and between MUP analysis programs in normal subjects.
  • 2011
    Finan, Dina; Pfeffer, Suzanne R.; Spudich, James A.; Straight, Aaron.
    Molecular motors are proteins that use energy from ATP hydrolysis to walk along cytoskeletal tracks, often transporting cargo as they move. A substantial amount of work has been done to study their catalytic domains, obtaining in vitro biochemical, structural, and biophysical measurements of motors' stepping behavior. Compared to this wealth of data, much less is known about how they actually work in cells. Regions of the motor proteins called cargo-binding domains are responsible for mediating their interactions with other molecules, but we know relatively little about what specific cargoes they associate with, the biochemical basis of these interactions, how they are regulated, and thus the precise functions of the motors in vivo. We have focused on two unconventional myosin motors in Drosophila, V and VI, both of which play important roles in fly development, and whose cargo-binding domains have been relatively unexplored. We use a proteomics approach to identify multiple novel binding partners for both myosins. The identities and biochemical characterization of a small fraction of the candidate binding proteins have begun to shed light on pathways in which the motors are likely to be involved. We have focused on roles for myosin VI in protein secretion and intracellular trafficking, and it seems likely that myosin V will play distinct roles in trafficking of ribonucleoprotein complexes. The discovery of binding partners is an important step towards understanding what motors do in cells, and we expect that this method will be useful for other motors in the future. We also hope that these findings will continue to elucidate biological roles of myosin V and VI.
  • 2011 Springer
    Brakebusch, Cord; Pihlajaniemi, Taina.
    Genomic insulators in transgenic animals -- German mouse clinic: running an open access platform -- Nature and nurture: impacts on mouse phenotypes and translational research -- Informatics of high-throughput mouse phenotyping: EUMODIC and beyond -- Experimental tumour models in mice -- Exploration of MMP function in mouse models of angiogenesis -- Tumor-stroma interactions: focus on fibroblasts -- Experimental procedures to assay invasion-associated activities of primary cultured fibroblasts -- Systemic instigation: a mouse model to study breast cancer as a systemic disease.
  • 2011 ScienceDirect
    Wahlsten, D.
    Chapter 1. Introduction to the Research Process -- Chapter 2. Mice -- Chapter 3. Tests of Mouse Behavior -- Chapter 4. Designs -- Chapter 5. Sample Size -- Chapter 6. Ethics Approval -- Chapter 7. Logistics -- Chapter 8. Getting Ready for Testing -- Chapter 9. Prelude to Data Analysis -- Chapter 10. Domains and Test Batteries -- Chapter 11. Motivating Mice -- Chapter 12. Qualities of Behavioral Tests -- Chapter 13. Task Refinement and Standardization -- Chapter 14. Video Tracking -- Chapter 15. The Laboratory Environment.
  • 2008
    Franklin, Keith B. J.; Paxinos, George.
  • 2012 Springer
    Kubiak, Jacek Z.
    Post-transcriptional Control of Gene Expression During Mouse Oogenesis / Hugh J. Clarke -- Polarity and Asymmetry During Mouse Oogenesis and Oocyte Maturation / Malgorzata Kloc, Rafik M. Ghobrial, Ewa Borsuk and Jacek Z. Kubiak -- Chromatin Structure and ATRX Function in Mouse Oocytes / Rabindranath De La Fuente, Claudia Baumann and Maria M. Viveiros -- Cyclin B in Mouse Oocytes and Embryos: Importance for Human Reproduction and Aneuploidy / Zbigniew Polański, Hayden Homer and Jacek Z. Kubiak -- Src Protein Kinases in Mouse and Rat Oocytes and Embryos / Mattan Levi, Lihi Ninio-Mani and Ruth Shalgi -- Gradual Meiosis-To-Mitosis Transition in the Early Mouse Embryo / Aurélien Courtois and Takashi Hiiragi -- Maternal Control of Mouse Preimplantation Development / Wenjing Zheng and Kui Liu -- Preimplantation Mouse Embryo: Developmental Fate and Potency of Blastomeres / Aneta Suwińska -- Creation of Trophectoderm, the First Epithelium, in Mouse Preimplantation Development / Yusuke Marikawa and Vernadeth B. Alarcon -- Cell Lineage Allocation Within the Inner Cell Mass of the Mouse Blastocyst / Panagiotis Xenopoulos, Minjung Kang and Anna-Katerina Hadjantonakis -- Formation of Distinct Cell Types in the Mouse Blastocyst / Samantha A. Morris and Magdalena Zernicka-Goetz -- Cell Movements in the Egg Cylinder Stage Mouse Embryo / Bradley Joyce and Shankar Srinivas -- Balancing the Dose in the Mouse / Mary E. Donohoe -- Mouse Oviduct Development / C. Allison Stewart and Richard R. Behringer -- Cell Lineages, Growth and Repair of the Mouse Heart / Fabienne Lescroart and Sigolène M. Meilhac -- Cellular Reprogramming During Mouse Development / Zoë D. Burke, Gabriela Miron-Buchacra and David Tosh -- Differentiation of Definitive Endoderm from Mouse Embryonic Stem Cells / Peter T. W. Kim and Christopher J. Ong -- Mouse and Human Pluripotent Stem Cells and the Means of Their Myogenic Differentiation / I. Grabowska, K. Archacka, A. M. Czerwinska, M. Krupa and M. A. Ciemerych -- Stem Cells and Corneal Epithelial Maintenance: Insights from the Mouse and Other Animal Models / Richard L. Mort, Panagiotis Douvaras, Steven D. Morley, Natalie Dorà and Robert E. Hill, et al. -- Mouse-Induced Pluripotent Stem Cells / Hui Zhang and Ying Jin -- Aging in the Mouse and Perspectives of Rejuvenation Through Induced Pluripotent Stem Cells (iPSCs) / Ken-ichi Isobe, Zhao Cheng, Sachiko Ito and Naomi Nishio.
    Also available: Print – 2012
  • 2002 ScienceDirect
    Rossant, Janet; Tam, Patrick P. L.
  • 2014 Springer Protocols
    Coppola, Vincenzo; Singh, Shree Ram.
  • 2010
    McGarry, Michael P.; Lee, James J.; Protheroe, Cheryl A.
    Status: Not Checked OutLane Catalog Record
    Collection of peripheral blood -- Counting red blood cells, platelets, and viable nucleated white blood cells -- Protocol 1 determination of percent red cell volume (hematocrit) -- Protocol 2 methodology to determine a red blood cell count using a hemacytometer -- Protocol 3 methodology to determine a platelet cell count using a unopette and a hemacytometer -- Protocol 4 methodology to determine a white blood cell count and viability using a hemacytometer -- Peripheral blood films and cytospin preparations -- Protocol 5 washing slides in preparation for microscopic examination of peripheral blood and bone marrow -- Protocol 6 preparation of a peripheral blood film -- Protocol 7 fixing, staining, and mounting a peripheral blood film -- Protocol 8 preparation of a peripheral blood suspension for cytospin analysis -- Cell differential assessments of peripheral blood films -- Preparation of bone marrow for microscopic examination -- Protocol 9 bone marrow biopsy of the mouse -- Protocol 10 preparation of a bone marrow brush smear -- Protocol 11 preparation of a bone marrow suspension for cytospin analysis -- Cell differential assessments of bone marrow.
  • v. 1-4, 2007.
    Fox, James G.
    Status: Not Checked OutLane Catalog Record
    v. 1. History, wild mice, and genetics - - v. 2. Diseases - - v. 3. Normative biology, husbandry, and models - - v. 4. Immunology
  • 2013 Springer Protocols
    Allen, Irving C.
    Transgenic Mouse Models -- Pulmonary Antigen Presenting Cells: Isolation, Purification, and Culture -- Evaluation of T Cell Function in Allergic Disease -- Evaluating B-Cells: From Bone Marrow Precursors to Antibody Producing Cells -- Protocols for Identifying, Enumerating and Assessing Mouse Eosinophils -- Evaluation of Classical, Alternative, and Regulatory Functions of Bone Marrow-Derived Macrophages -- Applications of Mouse Airway Epithelial Cell Culture for Asthma Research -- Isolation and Characterization of Mast Cells in Mouse Models of Allergic Diseases -- Purifying and Measuring Immunoglobulin E (IgE) and Anti-IgE -- Protocols for the Induction and Evaluation of Systemic Anaphylaxis in Mice -- Contact Hypersensitivity Models in Mice -- Induction of Allergic Rhinitis in Mice -- Induction of Allergic Airway Disease Using House Dust Mite Allergen -- An Inhalation Model of Allergic Fungal Asthma: Aspergillus fumigatus-Induced Inflammation and Remodeling in Allergic Airways Disease -- PAMPs and DAMPs in Allergy Exacerbation Models -- Assessment of Airway Hyperresponsiveness in Mouse Models of Allergic Lung Disease Using Detailed Measurements of Respiratory Mechanics -- Bilateral Vagotomy as a Tool for Determining Autonomic Involvement in Airway Responses in Mouse Models of Asthma -- Clara Epithelial Cell Depletion in the Lung -- A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma -- Assessment of Airway Hyperresponsiveness in Murine Tracheal Rings -- Use of the Cockroach Antigen Model of Acute Asthma to Determine the Immunomodulatory Role of Early Exposure to Gastrointestinal Infection -- Expression Profiling to Identify Candidate Genes Associated with Allergic Phenotypes -- Flow Cytometric Methods for the Assessment of Allergic Disease -- Generation of Bone Marrow and Fetal Liver Chimeric Mice.
  • 2015 Springer Protocols
    Casanova, Emilio; Eferl, Robert.
    Modeling cancer using genetically engineered mice / Patricia Stiedl ... [and 4 others] -- Lung adenocarcinomas : comparison between mice and men / Helmut H. Popper -- Mouse models of breast cancer / Kazuhito Sakamoto, Jeffrey W. Schmidt, and Kay-Uwe Wagner -- Genetically engineered mouse models to study prostate cancer / Elspeth A. Brzezinska ... [and 3 others] -- Practical use of advanced mouse models for lung cancer / Roghaiyeh Safari and Ralph Meuwissen -- Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations / Johan H. van Es and Hans Clevers -- Induction of colorectal cancer in mice and histomorphometric evaluation of tumors / Ilija Crncec ... [and 3 others] -- Mouse models of liver cancer / Jorge Matias Caviglia and Robert F. Schwabe -- Current methods in mouse models of pancreatic cancer / Pawel K. Mazur ... [and 3 others] -- Mouse models of nonmelanoma skin cancer / Nicole Amberg ... [and 5 others] -- Clinicopathological characterization of mouse models of melanoma / Blake Ferguson, H. Peter Soyer, and Graeme J. Walker -- Modeling BCR/ABL-driven malignancies in the mouse / Christine Schneckenleithner, Andrea Hoelbl-Kovacic, and Veronika Sexl -- Methods to generate genetically engineered mouse models of soft tissue sarcoma / Rebecca D. Dodd ... [and 5 others] -- Characterization of mouse model-derived osteosarcoma (OS) cells in vitro and in vivo / Özge Uluçkan, Latifa Bakiri, and Erwin F. Wagner -- Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma / Claudia A. Benavente and Michael A. Dyer -- Tumor imaging technologies in mouse models / Michael Bouvet and Robert M. Hoffman -- Tumor angiogenesis : methods to analyze tumor vasculature and vessel normalization in mouse models of cancer / Federica Maione and Enrico Giraudo -- Transplantable mouse tumor models of breast cancer metastasis / Rumela Chakrabarti and Yibin Kang -- Methods to study primary tumor cells and residual tumor cells in mouse models of oncogene dependence / Caroline Botta ... [and 3 others] -- Generation of transgenic mouse model using PTTG as an oncogene / Sham S. Kakar and Cohin Kakar -- Modeling the study of DNA damage responses in mice / Julia Specks ... [and 3 others] -- Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice / Eva Bauer ... [and 3 others].
  • 2008 Springer
    Li, Shaoguang.
  • 2013 Springer Protocols
    Allen, Irving C.
    The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
  • 2014 Springer Protocols
    Lewandoski, Mark.
    In situ Hybridization Methods for Mouse Whole Mounts and Tissue Sections with and Without Additional [beta]-galactosidase Staining -- Two Color In Situ Hybridization of Whole-Mount Mouse Embryos -- Detection and Monitoring of MicroRNA Expression in Developing Mouse Brain and Fixed Brain Cryosections -- Laser Capture Microdissection of Embryonic Cells and Preparation of RNA for Microarray Assays -- EMAGE: Electronic Mouse Atlas of Gene Expression -- Real-time PCR Quantification of gene Expression in Embryonic Mouse Tissue -- Identifying Essential Genes in Mouse Development Via an ENU-based Forward Genetic Approach -- Generation of Mouse Embryos with Small Hairpin RNA-mediated Knockdown of Gene Expression -- Generation of Tissue Organoids by Compaction Reaggregation -- Ultra-Rapid Vitrification of Mouse Oocytes and Embryos -- Mammalian Preimplantation Embryo Culture -- Serum-Free Culture of Mid-Gestation Mouse Embryos: A Tool for the Study of Endoderm-Derived Organs -- Genetically Encoded Probes Provide a Window On Embryonic Arrhythmia -- Microscopic Computed Tomography-based Skeletal Phenotyping for Genetic Model Organisms -- Gene Transfer Techniques in Whole Embryo Cultured Post-Implantation Mouse Embryos -- Segmentation and Quantitative Analysis of Individual Cells in Developmental Tissues -- Protein/Peptide Transduction in Metanephric Explant Culture -- Direction of Cells Programmed to Die in Mouse Embroys -- Microscopic Computed Tomography-based ?Virtual Histology of Embryos -- Collection and Preparation of Rodent Embryonic Samples for Transcriptome Study -- The Latest Improvements in the Mouse Sperm Preservation -- Analyzing Gene Function in Whole Mouse Embryo and Fetal Organ in vitro -- Using the Textpresso Site Specific Recombinases Web Server to Identify ?Cre Expressing Mouse Strains and Floxed Alleles -- Live Imaging Mouse Embryonic Development: Seeing is Believing and Revealing -- Genetic Cell Ablation -- Essentials of Recombinase-based Genetic Fate Mapping in Mice.
  • 2012 ScienceDirect
    Paxinos, George; Puelles, L.; Watson, Charles.
    The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlases A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness.
  • v. 1-2, 1930-.
    MacNevin, Malcolm Graeme; Vaughan, Harold Stearns.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Frucht, Steven J.
    A Brief Introduction to Movement Disorders / Steven J. Frucht -- Acute Parkinsonism / Hubert H. Fernandez and Joseph H. Friedman -- Parkinsonism-Hyperpyrexia Syndrome in Parkinson's Disease / Daniel E. Huddleston and Stewart A. Factor -- Neuroleptic Malignant Syndrome / Stanley N. Caroff, Stephan C. Mann, Kenneth A. Sullivan and E. Cabrina Campbell -- Malignant Catatonia / Stephan C. Mann, Stanley N. Caroff, Henry R. Bleier and E. Cabrina Campbell -- Psychosis and Parkinson's Disease / Christina L. Vaughan and Jennifer G. Goldman -- Abductor Paresis in Shy-Drager Disease / Eiji Isozaki -- Movement Disorder Emergencies of the Upper Aerodigestive Tract / Lesley Childs, Scott Rickert, Boris Bentsianov, Ajay Chitkara and Anthony Cultrara, et al. -- Dystonic Storm / Melissa J. Nirenberg and Blair Ford -- Pseudodystonic Emergencies / Jong-Min Kim and Beom S. Jeon -- Tardive and Neuroleptic-Induced Emergencies / Paul E. Greene and Steven J. Frucht -- Hemiballism-Hemichorea / Ronald B. Postuma and Anthony E. Lang -- Sydenham's Chorea, PANDAS, and Other Post-streptococcal Neurological Disorders / Roser Pons -- Emergencies in Huntington's Disease / Kathleen M. Shannon -- Acute Spinal Rigidity / P. D. Thompson -- Tic Emergencies / Vanessa K. Hinson and Christopher G. Goetz -- Malignant Phonic Tics / Joseph Jankovic -- Serotonin Syndrome / Mark Forrest Gordon and Adena N. Leder -- Risks and Dangers from Hyperekplexia and Other Startle Disorders / Frederick Andermann and Eva Andermann -- Perioperative Emergencies Associated with Deep Brain Stimulation / Takashi Morishita, Adam P. Burdick and Michael S. Okun -- Psychogenic Movement Disorders / Daniel Schneider and Daniel T. Williams -- Anti-NMDA Receptor Encephalitis and Other Autoimmune and Paraneoplastic Movement Disorders / Jessica Panzer and Josep Dalmau -- Wilson's Disease / George J. Brewer -- Dopa-Responsive Dystonia / Yoshiaki Furukawa, Mark Guttman, Shinichiro Nakamura and Stephen J. Kish -- Whipple's Disease / Eoin Mulroy, John Lynch and Tim Lynch -- Driving Risk in Patients with Movement Disorders / Ergun Y. Uc -- Genetics and Genetic Counseling Related Issues / Martha A. Nance -- Suicide Risk in Parkinson's Disease / Valerie Voon.
  • 2015 Springer
    Brás, José M. Tomás; Schneider, Susanne A.
    This book covers recent developments and possible pitfalls in the diagnosis of genetic movement disorders and related conditions. It is divided into three sections: technical and scientific aspects; clinical aspects with guidance towards work-up; and ethical and legal aspects of genetic testing in a clinical and research setting. The first section includes chapters on genetic analysis and counselling with critical discussion of potential problems when interpreting the results. Clinical chapters summarize genetic forms of movement disorders including parkinsonism, tics and dystonia with algorithms for hands-on daily practice. Related conditions such as RLS, ataxias and dementias are also covered. Finally, chapters on ethical and legal aspects of genetic testing are included. Movement Disorder Genetics is aimed at clinicians and scientists working in the field of movement disorders and related conditions. .
  • 2008 Thieme eNeurosurgery
    Bakay, Roy A. E.
    History of surgery for movement disorders / Philip L. Gildenberg -- Rational for movement disorder surgery / Cameron C. McIntyre ... [et al.] -- Setting up a practice / Brian Harris Kopell, Kenneth Baker, Nicholas M. Boulis -- Selection of patients, centers and disorders / Leo Verhagen Metman -- Preparation for surgery / Ron L. Alterman, Michele Tagliati -- Anesthesia for movement disorder surgery / Robert E. Gross, Klaus Mewes, Ghaleb Ghani -- Stereotactic surgery with microelectrode recordings / Diane Sierens ... [et al.] -- Stereotactic surgery without microelectrode recording / Marwan I. Hariz, Nathalie Vayssière -- Implantation of multiple electrode and robotic techniques / Alim Louis Benabid ... [et al.] -- Frameless functional stereotactic approaches / Jaimie M. Henderson -- Deep brain stimulation for tremor / Jorge L. Eller, Kim J. Burchiel -- Deep brain stimulation for dystonia / Brian Harris Kopell, Craig I. Horenstein, Ali R. Rezai -- Deep brain stimulation programming / Erwin B. Montgomery, Jr. -- Avoiding complications and correcting errors / Philip A. Starr -- Efficacy and complications of deep brain stimulation for movement disorders / Erich O. Richter, Clement Hamani, Andres M. Lozano -- Gamma knife / Ronald F. Young -- Future directions in movement disorders surgery / Shivanand P. Lad ... [et al.].
  • 2015 ScienceDirect
    LeDoux, Mark.
    Section I: Scientific foundations. Taxonomy and clinical features of movement disorders -- Modeling disorders of movement -- New transgenic technologies -- Assessment of movement disorders in rodents -- Drosophila -- Use of Caenorhabditis elegans to model human movement disorders -- Zebrafish -- Techniques for motor assessment in rodents -- Induced pluripotent stem cells (iPSCs) to study and treat movement disorders -- Neurophysiologic assessment of movement disorders in humans -- Neurophysiological and optogenetic assessment of brain networks involved in motor control -- Functional imaging to study movement disorders -- Human and nonhuman primate neurophysiology to understand the pathophysiology of movement disorders -- Section II: Parkinson disease. The phenotypic spectrum of Parkinson disease -- genetics and molecular biology of Parkinson disease -- Genotype-phenotype correlations in Parkinson Disease -- From man to mouse: the MPTP model of Parkinson disease -- Rodent models of autosomal dominant Parkinson disease -- Rodent models of autosomal recessive Parkinson disease -- Drosophila models of Parkinson Disease -- Primate models of complications related to Parkinson disease treatment -- Rodent models of treatment-related complications in Parkinson disease -- Methods and models of the nonmotor symptoms of Parkinson disease -- Section III: Dystonia. Dystonia: phenotypes and genetics -- Murine models of caytaxin deficiency -- Animal models of focal dystonia -- Mouse models of dystonia -- Rodent models of autosomal dominant primary dystonia -- Modeling dystonia-parkinsonism -- Section IV: Huntington disease. Genetics of Huntington disease (HD), HD-like disorders, and other choreiform disorders -- Murine models of HD -- Use of genetically engineered mice to study the biology of huntingtin -- Modeling Huntington disease in yeast and invertebrates -- HDL2 mouse -- Analysis of nonmotor features in murine models of Huntington Disease -- Section V: Tremor. Essential tremor -- Use of the harmaline and [alpha]1 knockout models to identify molecular targets for essential tremor -- Physiological and behavioral assessment of tremor in rodents -- Mouse models of the fragile X tremor/ataxia syndrome (FXTAS) and the fragile X premutation -- Section VI: Myoclonus. Myoclonus: Classification, Clinical Features, and Genetics -- Mouse model of Unverricht-Lundborg disease -- Post-hypoxic myoclonus in rodents -- Generating mouse models of mitochondrial disease -- Secion VII: Tics. Tics and Tourette Syndrome: Phenomenology -- Genetics of Tourette syndrome -- Neural circuit abnormalities in Tourette syndrome -- Animal models of Tourette Syndrome and obsessive-compulsive disorder -- Section VIII: Paroxysmal movement disorders. Paroxysmal Movement Disorders: Clinical and Genetic Features -- Mouse models of PNKD -- Glut1 deficiency (G1D) -- Animal models of episodic ataxia type 1 (EA1) -- Mouse models of episodic ataxia type 2. Section IX: Tauopathies. Tauopathies: Classification, Clinical Features, and Genetics -- Drosophila models of tauopathy -- Tauopathy mouse models -- Tau protein: biology and pathobiology -- Section X: Other Parkinsonian syndromes: NBIA, MSA, PD + spasticity, PD + dystonia. Clinical Phenomenology and genetics of other parkinsonian syndromes associated with either dystonia or spasticity -- Animal models of multiple-system atrophy -- Modeling PKAN in mice and flies -- Mouse models of FA2H deficiency -- Mouse models of neuroaxonal dystrophy caused by PLA2G6 gene mutations -- Section XI: Ataxias. Genetics and Clinical Features of Inherited Ataxias -- Animal models of spinocerebellar ataxia type 1 -- Mouse models of SCA3 and other polyglutamine repeat ataxias -- animal models of Friedreich ataxia -- Ataxia-telangiectasia and the biology of ataxia-telangiectasia mutated (ATM) -- Autosomal recessive ataxias due to defects in DNA repair -- Caenorhabditis elegans models to study the molecular biology of ataxias -- Section XII: Hereditary spastic paraplegia. Hereditary Spastic Paraplegias: Genetics and Clinical Features -- Mouse models of autosomal dominant spastic paraplegia -- Murine models of autosomal recessive hereditary spastic paraplegia -- Modeling hereditary spastic paraplegia (HSP) in zebrafish -- Drosophila models of hereditary spastic paraplegia -- Caenorhabditis elegans models of hereditary spastic paraplegia -- Use of arabidopsis to model hereditary spastic paraplegia and other movement disorders -- Section XIII: Restless legs syndrome. Clinical Phenotype and Genetics of Restless Legs Syndrome -- Combined D3 receptor/iron-deficient mouse model -- Use of Drosophila to study restless legs syndrome -- The A11 lesion/iron deprivation animal model of restless legs syndrome -- Btbd9 knockout mice as a model of restless legs syndrome.
  • 2010 ClinicalKey
    Singer, Harvey S.
    Experts in the field, Drs. Singer, Mink, Gilbert, and Jankovic, fill the gap in the market by offering the only comprehensive text devoted solely to the diagnoses and treatment of all pediatric movement disorders. Discussions of common and rare disorders such as movements that occur in sleep and psychogenic movement disorders and the latest advances and developments in medications keep you apprised of today₂s best practices. Each chapter is accessible, illustrated, stylistically uniform, and carefully referenced, making it easy to access the information you need. This brand-new reference is the ideal resource for the seasoned specialist as well as the non-expert clinician. Best of all, Expert Consult functionality gives you convenient access to the full text online - fully searchable, a downloadable image library, and enhanced visual guidance with narrated, diagnostic videos at expertconsult.com. ₅ Includes online access to the complete contents of the book, fully searchable, including all of the book₂s illustrations, 58 narrated videos of actual patients and their disorders, and abstracts to Medline at expertconsult.com. Discusses neurobiology, classification, diagnostic evaluation, and treatment, making this a one-stop-shop for all you need to know to diagnose and treat any child with any movement disorder.
  • 2010 Springer
    Chaudhuri, K. Ray; Logishetty, Kartik; Ondo, William G.; Reddy, Prashanth; Sherman, Rosalie.
    Ch. 1. Introduction -- Ch. 2. Parkinsonism: Parkinson's disease -- Ch. 3. Parkinsonism: Parkinson's plus -- Ch. 4. Surgery for Parkinson's disease -- Ch. 5. Tremor -- Ch. 6. Dystonia -- Ch. 7. Chorea -- Ch. 8. Tics and related disorders -- Ch. 9. Myoclonus -- Ch. 10. Movement disorders during sleep -- Ch. 11. Drug-induced movement disorders -- Ch. 12. Paediatric movement disorders -- Ch. 13. Psychogenic movement disorders -- Ch. 14. Other dyskinesias.
  • 2014 Springer
    Merello, Marcelo J.; Starkstein, Sergio E.
    "This book focuses on extrapyramidal signs and symptoms of all types of dementia, and addresses the issue of the artificial boundary between dementias and Parkinsonism, which represent the two most common symptoms found in degenerative central nervous system diseases. In Movement Disorders in Dementias, movement disorder specialists from around the world write on topics generally restricted to dementia experts. Important motor issues related to either medication in demented patients (drug-induced movement disorders) or manifestations common to all forms of dementia, regardless of underlying cause (gait disorders, falls, fear of falling), is followed by analysis of the relationship between motor and cognitive symptoms, from their common pathogenesis to specific medical treatments. Movement Disorders in Dementias is aimed at general neurologists, dementia specialists, movement disorders specialists, neuropsychologists and geriatricians."--Publisher's website.
  • 2010
    Kalmar, Rachel Stern; Moore, Tirin; Newsome, William T.; Shenoy, Krishna V.; Wandell, Brian A.
    Movement preparation allows the rapid and accurate execution of voluntary movements, and can be influenced by factors that may change from moment to moment, such as attention and differences in stimulus properties. Consequently, movement preparation unfolds differently across many repetitions of the same movement. Averaging neural responses across many repetitions is necessary to interpret single-cell recordings, but diminishes our ability to characterize the dynamics of the underlying process. A central question in neuroscience, and also of fundamental clinical importance, is to understand how these plans develop in the brain. Several research groups are starting to build prosthetic devices that are controlled directly by neural activity in motor areas of the brain (Nicolelis, 2001; Donoghue, 2002; Musallam et al., 2004; Schwartz, 2004; Santhanam et al., 2006; Hochberg et al., 2006; Mulliken et al., 2008; Andersen et al., 2010), but the extent to which these can be developed may hinge critically upon our understanding of the neural basis of motor preparation. Simultaneous recording from populations of neurons allows dynamics of movement preparation to be estimated on single trials. Our goal is to characterize these dynamics, to gain insight into the process underlying movement preparation. Here, we recorded peri-saccadic activity from ensembles of neurons in an oculomotor area, prearcuate cortex, in two monkeys. While monkeys performed visually-guided eye movements, we measured firing rates of a population of neurons using a 96-electrode array. We studied (1) the responses from a heterogeneous population of prearcuate cortex neurons involved in decision-making and movement preparation, (2) the relationship between saccade initiation times and responses from the neural population, and (3) how these responses compared to those recorded in PMd, a cortical area involved in arm movements. The array data from prearcuate allowed us to compare responses from individual neurons with previous findings, but also allowed us to analyze the population dynamics of movement planning, by using techniques applied to the reach system. We found that ensemble responses from diverse populations of prearcuate neurons (1) can be visualized as trajectories moving through a low-dimensional neural state space, (2) reflect visual, decision-, and movement-related aspects of the task, and (3) correlate with a monkey's reaction time on a trial-by-trial basis. Further, the single-trial relationship between ensemble activity in prearcuate cortex and saccadic reaction times was qualitatively and quantitatively very similar to the relationship between ensemble activity in PMd and corresponding reach reaction times. This framework for analyzing neural population activity and dynamics should permit new extensions of single-neuron-level models, and may offer further insight into general mechanisms of movement preparation across motor systems.
  • 2014 Thieme eNeurosurgery
    Khan, Nadia; Spetzler, Robert F.; Wanebo, John E.; Zabramski, Joseph M.
    "This multi-authored, well-organized monograph is a must read for any physician involved in the care of patients with Mmoyamoya disease. It is moderately short and very easy to read but still provides a state-of-the-art review of the disease with updated aspects, especially in its etiology and pathogenesis, epidemiology, and long-term results"--Provided by publisher.
  • 2010 Springer
    Cho, Byung-Kyu; Tominaga, Teiji.
  • 2010 Springer
    Caramella, D.; Cosottini, Mirco; Neri, E.
  • 2006 Springer
    Hoe, L. van; Hoe, L. van.
  • 2014 Springer
    Mazziotti, Silvio; Ascenti, Giorgio; Blandino, Alfredo.
    In recent years, there has been huge interest in developing new methods that offer improved accuracy for the detection of small bowel pathology, and in particular for the assessment of inflammatory bowel diseases (IBD). Cross-sectional imaging, such as CT and MR, has advantages over traditional barium fluoroscopic techniques in terms of direct visualization of the bowel wall and improved visualization of extraluminal findings and complications. This means a complete change in the diagnostic approach to the patient with IBD: from analysis of the bowel surface to direct evaluation of parietal alterations and assessment of peri- and extraintestinal involvement. The ideal imaging test is reproducible, well tolerated by patients and, above all, free of ionizing radiation. MR enterography, currently performed only in a few reference centers, meets these criteria and offers accurate diagnosis, particularly in respect of the wide spectrum of intra- and extraintestinal complications of IBD. This book provides a thorough overview of the indications, techniques, diagnostic advantages, and limitations of MR enterography. Particular attention is paid to patient preparation in relation to the particular study type and to the potential advantages of the most up-to-date MR studies in specific cases, e.g., allergy or renal failure. A separate chapter is devoted to MR of perianal region for the detection and staging of perianal fistula, a common complication in patients with Crohn's disease. Numerous high-quality illustrations are included and help to ensure that the book will be a valuable source of information for every radiologist involved in abdominal MR imaging.
  • 2005 Springer
    Bammer, R.; Filippi, M.
  • 2010 Thieme Book
    Hamm, Bernd.
    "Presented by a team of experts in the speciality, this book provides a comprehensive overview of MRI of the abdomen and pelvis in adult and pediatric patients. The book's organization by organ or organ system allows the reader to approach the field one topic at a time. Each chapter lists the indications for MRI, describes in detail the specific imaging technique, and shows the MRI appearance of normal anatomy and pathologic entities."--Back cover.
  • 2013 Springer
    Blüml, Stefan; Panigrahy, Ashok.
    Introduction -- The Developing Human Brain: Differences from Adult Brain -- Magnetic Resonance Spectroscopy: Basics -- Metabolites of Proton Magnetic Resonance Spectroscopy and Normal Age-Dependent Changes -- Challenges in Pediatric Magnetic Resonance Imaging -- Pathologies -- Magnetic Resonance Spectroscopy of Pediatric Brain Tumors -- Diffuse Intrinsic Pontine Gliomas -- Traumatic Brain Injury and Concussion -- Proton Magnetic Resonance Spectroscopy: Applications in Neonatal Medicine -- Proton Magnetic Resonance Spectroscopy: Application in Non-Accidental Trauma -- Leukodystrophies -- Metabolic Disorders -- Phenylketonuria -- Infection and Encephalitis -- Hepatic Encephalopathy in Children -- Magnetic Resonance Spectroscopy in Epilepsy -- ¹H Magnetic Resonance Spectroscopy of the Brain During Adolescence: Normal Brain Development and Neuropsychiatric Disorders -- Magnetic Resonance Spectroscopy Studies of Autistic Spectrum Disorders -- Magnetic Resonance Spectroscopy Studies of Attention Deficit Hyperactivity Disorder -- Magnetic Resonance Spectroscopy of the Fetal Brain -- MRS of the Neonatal Brain: Abnormal Development and Neonatal Pathology.
  • 2003 Wellcome Trust
    Reynolds, Lois A.; Tansey, E. M.
    "This transcript considers the origins and impact of the MRC Applied Psychology Unit's work from 1944 to 1998."
  • 2010
    Brown, Mark A.; Semelka, Richard C.
    Status: Not Checked OutLane Catalog Record
    Production of Net Magnetization -- Concepts of Magnetic Resonance -- Relaxation -- Principles of Magnetic Resonance Imaging: part 1 -- Principles of Magnetic Resonance Imaging: part 2 -- Pulse Sequences -- Measurement Parameters and Image Contrast -- Signal Suppression Techniques -- Artifacts -- Motion Artifact Reduction Techniques -- Magnetic Resonance Angiography -- Advanced Imaging Applications -- Magnetic Resonance Spectroscopy -- Instrumentation -- Contrast Agents -- Safety -- Clinical Applications.
  • 2010
    Hashemi, Ray H.; Bradley, William G.; Lisanti, Christopher J.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Beinder, E.; Forstner, R.; Hamm, Bernd.
  • 2007 Springer
    Herwig, Bettina; Weyreuther, Martin.
  • 2008 Springer
    Sahraian, M. A.; Radue, E.-W.
  • 2012 CRCnetBASE
    Placidi, Giuseppe.
    Pt. 1. Basic concepts -- pt. 2. Limitations of conventional MRI -- pt. 3. Advanced solutions -- pt. 4. The future.
  • 2014 Thieme eNeurosurgery
    Khanna, A. Jay.
    Essentials of MRI physics and pulse sequences / Shivani Ahlawat, Rick W. Obray, Douglas P. Beall, John D. Reeder, John A. Carrino, and Laura M. Fayad -- Normal spine MRI anatomy / Swati Deshmukh, John A. Carrino, J. Dana Dunleavy, and A. Jay Khanna -- Common clinical and correlative pain generators of the cervical and lumbosacral spine / Josemaria Paterno, Chad M. Silverberg, A. Jay Khanna, and Aneesh K. Singla -- A systematic approach to the review of spine MRI studies / A. Jay Khanna -- The occipitocervical junction / Colin M. Haines, A. Jay Khanna, John A. Carrino, Shih-Chun David Lin, and Joseph R. O'Brien -- The cervical spine / Lukas P. Zebala, Jacob M. Buchowski, Aditya Daftary, Joseph R. O'Brien, John A. Carrino, and A. Jay Khanna -- The lumbar and thoracic spine / Gbolahan O. Okubadejo, Aditya Daftary, Jacob M. Buchowski, John A. Carrino, and A. Jay Khanna -- Tumors of the spine / Daniel M. Sciubba, Patricia L. Zadnik, Bruce A. Wasserman, and Ziya L. Gokaslan -- MRI of the pediatric spine / A. Jay Khanna, Bruce A. Wasserman, and Paul D. Sponseller -- Advanced techniques in spine MRI / Joseph P. Gjolaj and John A. Carrino -- Correlation of MRI with other imaging studies / Shivani Ahlawat, Uma Srikumaran, A. Jay Khanna, and Laura M. Fayad -- MRI safety considerations for the referring clinician / Monica D. Watkins and Bruce A. Wasserman.
  • 2010 Springer
    Liney, Gary.
  • 2007 Cambridge
    Graves, Martin J.; McRobbie, Donald W.; Moore, Elizabeth A.; Prince, Martin R.
    MR : what's the attraction? -- Early daze : your first week in MR -- Seeing is believing : introduction to image contrast -- The devil's in the detail : pixels, matrices, and slices -- What you set is what you get : basic image optimization -- Improving your image : how to avoid artefacts -- Spaced out : spatial encoding -- Getting in tune : resonance and relaxation -- Let's talk technical : MR equipment -- But is it safe? : bio-effects -- Ghosts in the machine : quality control -- Acronyms anonymous : a guide to the pulse sequence jungle -- Go with the flow : MR angiography -- A heart to heart discussion : cardiac MRI -- It's not just squiggles : in-vivo spectroscopy -- To BOLDly go : new frontiers -- The parallel universe : parallel imaging and novel acquisition techniques -- Appendix: Maths revision.
    Also available: Print – 2007
  • 2012 Springer
    Elmaoğlu, Muhammed; Çelik, Azim.
    MRI Handbook presents a concise review of the physical principles underlying magnetic resonance imaging (MRI), explaining MR physics, patient positioning, and protocols in an easy-to-read format. The first five chapters of the book introduce the reader to the basics of MR imaging, including the relaxation concept, MR pulse sequences, and MR imaging parameters and options. The second part of the book (chapters 6-11) uses extensive illustrations, images, and protocol tables to explain tips and tricks to achieve optimal MR image quality while ensuring patient safety. Individual chapters are devoted to each major anatomic region, including the central nervous, musculoskeletal, and cardiovascular systems. By using annotated MR images and examples of patient positions used during scanning correlated with sample protocols and parameters, MRI Handbook is a practical resource for imaging professionals to use in the course of their daily practice as well as for students to learn the basic concepts of MR imaging.
  • 2006 Springer
    Liney, Gary.
  • 2013 Springer
    Urbach, Horst.
    MRI can play an important role in identifying and localizing epileptogenic foci. This book aims to provide the clinical and imaging information required in order to decide whether an MRI scan is appropriate and whether it is likely to be sufficient to detect a lesion. The first part of the book presents background information on epilepsy patients and explains how to perform an MRI examination. Detailed attention is paid to functional MRI and post-processing, and the examination of subcategories of patients is also discussed. The second part of the book then documents the MRI findings obtained.
  • 2014 Springer
    Mulert, Christoph; Shenton, Martha Elizabeth.
    This is the first comprehensive textbook on the use of MRI in psychiatry covering imaging techniques, brain systems and a review of findings in different psychiatric disorders. The book is divided into three sections, the first of which covers in detail all the major MRI-based methodological approaches available today, including fMRI, EEG-fMRI, DTI, and MR spectroscopy. In addition, the role of MRI in imaging genetics and combined brain stimulation and imaging is carefully explained. The second section provides an overview of the different brain systems that are relevant for psychiatric disorders, including the systems for perception, emotion, cognition, and reward. The final part of the book presents the MRI findings that are obtained in all the major psychiatric disorders using the previously discussed techniques. Numerous carefully chosen images support the informative text, making this an ideal reference work for all practitioners and trainees with an interest in this flourishing field.
  • 2008 Thieme Book
    Meyers, Steven P.
    This book on radiology of musculoskeletal diseases is an aid for the radiologist evaluating problems of the bones, joints, and muscles. Comprehensive differential diagnostic tables are juxtaposed with excellent illustrations from all radiologic modalities. Along with the differential diagnoses, helpful hints for further evaluation or narrowing the diagnosis are provided.
  • 2011 Springer
    Kastler, Bruno.
    Patient preparation: magnetic resonance imaging techniques -- Cardiovascular anatomy and atlas of MR normal anatomy -- MRI sequential segmental analysis and identification of anomalies -- Anomalous systemic and pulmonary venous connections -- Aortic arch anomalies, tracheal compression and stenosis -- Other aortic malformations -- Anomalies of the right ventricular outflow tract and pulmonary arteries -- Postoperative evaluation
  • 2015 Springer
    D'Aprile, Paola; Tarantino, Alfredo.
    This richly illustrated case-based atlas thoroughly depicts the role of MR imaging in the assessment of patients presenting with pain due to degenerative disease of the spine and will serve as an excellent guide to differential diagnosis. Importantly, generic radicular compression is the main reason for the painful symptomatology in only a limited number of cases, and this book illustrates and emphasizes how various anatomic elements of the spine can be responsible. The imaging features of a range of disorders involving both the anterior and posterior elements of the spine are described, including active inflammatory osteochondrosis, atypical herniated discs, facet joint disorders, spondylolysis, and degenerative-inflammatory changes of the spinal ligaments and posterior perispinal muscles. Each example is supported by clinical data, and a series of unusual cases are also presented. MR study protocols include T2-weighted sequences with fat saturation and contrast-enhanced T1-weighted sequences with fat saturation to allow better visualization or highlighting of various inflammatory changes in the spine. Radiologists, neuroradiologists, neurosurgeons, orthopedists, and rehabilitation physicians will all find this atlas a valuable asset in their practice.
  • 2010 Springer
    Schäfer, Arnd-Oliver; Langer, Mathias.
  • 2014 Springer
    D'Aprile, Paola.
  • 2015 Springer
    Manfredi, Riccardo; Mucelli, Roberto Pozzi.
    Based on the experience of two Italian referral centers, the book depicts the characteristic findings obtained when using MR imaging to study the male and female pelvis including the obstetric applications. Each chapter provides a comprehensive account of the use of the imaging technique of examination, including the most recent advances in MR imaging, the anatomy and MR possibilities in the identification, characterization and staging of the different pelvic diseases highlighting its diagnostic possibilities. The advances in fetal MRI, representing the cutting edge of pelvic MR imaging, will also be depicted. The text is complemented by numerous illustrations, as well as clinical cases that make this a very practice-oriented work, presenting the role of diagnostic imaging in every-day clinical activity. The volume will prove an invaluable guide for both residents and professionals with core interest in gynecology, obstetrics and urology.
  • 2010 Springer
    Baert, A. L.; Beets-Tan, Regina G. H.; Stoker, J.
    MRI of the gastrointestinal tract: coils, sequences, techniques -- MRI of the gastrointestinal tract at high-field strength -- Contrast media for MRI of the gastrointestinal tract -- Dynamic contrast-enhanced and diffusion-weighted MRI of the gastrointestinal tract -- MRI of the esophagus and stomach -- MRI of the upper GI tract motility -- MRI of the duodenum -- MRI of the small bowel: enterography -- MRI of the small bowel: enteroclysis -- MRI of the small bowel: clinical role -- MRI of the colon (MR colonography): technique -- MRI of the colon (colonography): results -- MRI of the rectum -- MRI of bowel motility -- MRI of the peritoneum -- MRI of adhesions and small bowel obstruction -- MRI of acute conditions of the gastrointestinal tract -- MRI of the pelvic floor -- MRI of the anus.
  • 2005 Springer
    Bartolozzi, C.; Lombardi, Massimo.
  • 2015 Springer
    Bolog, Nicolae V.; Andreisek, Gustav; Ulbrich, Erika J.
    This book is divided into chapters that cover MRI of all structures of the knee joint in the order that is usually used in practice ? cruciate ligaments, collateral ligaments, menisci, cartilage, subchondral bone, patella, synovia, muscles and tendons, arteries, veins and bones. With the aid of numerous images, each chapter provides comprehensive descriptions of the anatomy, the normal MR appearance, pathological MR findings, and postoperative MRI appearance. A text box at the end of each chapter clearly describes how the MRI report should be compiled and identifies what should be included when reporting on specific lesions. The book will be an ideal guide for radiologists and will also be relevant for orthopaedic surgeons, rheumatologists, and physiotherapists.
  • 2006 Springer
    Grazioli, Luigi; Saini, Sanjay; Schneider, Günther.
  • 2009 Springer
    Kauczor, H.-U.
  • 2006 Ovid
    Berquist, Thomas H.
    Basic principles and terminology of magnetic resonance imaging / Robert A. Pooley, Joel P. Felmlee, and Richard L. Morin -- Interpretation of magnetic resonance images / Mark S. Collins and Richard L. Ehman -- General technical considerations in musculoskeletal MRI / Thomas H. Berquist -- The temporomandibular joint / Thomas H. Berquist -- Spine / Robert Witte and John Lane -- Pelvis, hips, and thigh / Thomas H. Berquist -- Knee / Thomas H. Berquist -- Foot, ankle, and calf / Thomas H. Berquist -- Shoulder, arm / Thomas H. Berquist and Jeffrey J. Peterson -- Elbow and forearm / Thomas H. Berquist and Laura W. Bancroft -- Hand and wrist / Thomas H. Berquist -- Musculoskeletal neoplasms / Mark J. Kransdorf and Thomas H. Berquist -- Musculoskeletal infection / Thomas H. Berquist and Daniel F. Broderick -- Diffuse marrow diseases / James B. Vogler, III and William A. Murphy, Jr. -- Miscellaneous conditions / Thomas H. Berquist -- Clinical spectroscopy / Thomas H. Berquist.
    Also available: Print – 2006
  • 2010 Thieme Book
    Möller, Torsten B.; Reif, Emil.
  • 2015 Springer
    Brockmeier, Stephen F.
  • 2008
    Chang, Hernan R.
    Status: Not Checked OutLane Catalog Record
  • 2005 Springer
    Mühlmann, Heiner.
  • 2012 Springer Protocols
    Weichhart, Thomas.
    Mammalian target of rapamycin : a signaling kinase for every aspect of cellular life / Thomas Weichhart -- Biochemical and pharmacological inhibition of mTOR by rapamycin and an ATP-competitive mTOR inhibitor / Ker Yu and Lourdes Toral-Barza -- Evaluation of the nutrient-sensing mTOR pathway / Sungki Hong, Aristotle M. Mannan, and Ken Inoki -- mTor activity under hypoxia / Douangsone D. Vadysirisack and Leif W. Ellisen -- Isolation of the mTOR complexes by affinity purification / Dos D. Sarbassov [and others] -- An in vitro assay for the kinase activity of mTOR complex 2 / Jingxiang Huang -- Overexpression or downregulation of mTOR in mammalian cells / Mahmoud Khalil and Ivan Gout -- Detection of cytoplasmic and nuclear functions of mTOR by fractionation / Margit Rosner and Markus Hengstschläger -- Evaluation of rapamycin-induced cell death / Lorenzo Galluzzi [and others] -- Evaluation of mTOR-regulated mRNA translation / Valentina Iadevaia [and others] -- A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation / Angela Papageorgiou and Joseph Avruch -- Immunohistochemical analysis of mTOR activity in tissues / Jinhee Kim [and others] -- Assessing cell size and cell cycle regulation in cells with altered TOR activity / Megan Cully and Julian Downward -- Quantitative visualization of autophagy induction by mTOR inhibitors / Beat Nyfeler [and others] -- The in vivo evaluation of active-site TOR inhibitors in models of BCR-ABL+ leukemia / Matthew R. Janes and David A. Fruman -- Inducible raptor and rictor knockout mouse embryonic fibroblasts / Nadine Cybulski, Vittoria Zinzalla, and Michael N. Hall -- Expanding human T regulatory cells with the mTOR-inhibitor rapamycin / Manuela Battaglia, Angela Stabilini, and Eleonora Tresoldi -- Rapamycin-induced enhancement of vaccine efficacy in mice / Chinnaswamy Jagannath and Pearl Bakhru -- Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells / Koichi Araki and Bogumila T. Konieczny -- Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes / Greg M. Delgoffe and Jonathan D. Powell -- Evaluating the therapeutic potential of mTOR inhibitors using mouse genetics / Huawei Li, Jennifer L. Cotton, and David A. Guertin -- Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors / Qi-Wen Fan and William A. Weiss -- Assessing the function of mTOR in human embryonic stem cells / Jiaxi Zhou, Dong Li, and Fei Wang -- Video-EEG monitoring methods for characterizing rodent models of tuberous sclerosis and epilepsy / Nicholas R. Rensing, Dongjun Guo, and Michael Wong -- A genetic model to dissect the role of TSC-mTORC1 in neuronal cultures / Duyu Nie and Mustafa Sahin -- Tissue-specific ablation of TSC1 in pancreatic beta-cells / Hiroyuki Mori and Kun-Liang Guan -- A mouse model of diet-induced obesity and insulin resistance / Chao-Yung Wang and James K. Liao -- Rapamycin as immunosuppressant in murine transplantation model / Louis-Marie Charbonnier and Alain Le Moine -- Development of ATP-competitive mTOR inhibitors / Qingsong Liu [and others].
  • 2011 Future Med
    Platanias, Leonidas C.
    mTOR inhibitors in cancer treatment / Leonidas C. Platanias -- Overview and mechanism of action of mTOR inhibitors / Stéphane Oudard -- mTOR inhibitors in renal cell carcinoma / Piotr J. Wysocki -- mTOR inhibitors in hepatocellular carcinoma / Gerhard Treiber & Thomas Wex -- mTOR inhibitors in ovarian cancer / Susana M. Campos -- mTOR inhibitors in breast cancer / Ingrid A. Mayer -- mTOR inhibitors in Hodgkin's and non-Hodgkin's lymphomas / Sonali M. Smith.
  • 2010 Springer
    Houghton, Peter J.; Polunovskiĭ, V. A.
    mTORC1: a signalling integration node involved in cell growth -- The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions -- mTOR signaling in angiogenesis -- mTORC1 signaling and hypoxia -- mTOR signaling in glioblastoma: lessions learned from bench to bedside -- mTOR and cancer therapy: general principles -- mTOR and cancer therapy: clinical development and novel prospects -- Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer -- Downstream targets of mTORC1 -- Downstream of mTOR: translational and control of cancer -- Genome-wide analysis of translational control -- Translational control of cancer: implications for targeted therapy -- Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex.
  • 2012 Springer Protocols
    McGuckin, Michael A.; Thornton, David J.
    Mucin methods : genes encoding mucins and their genetic variation with a focus on gel-forming mucins / Karine Rousseau and Dallas M. Swallow -- Gel-forming and cell-associated mucins : preparation for structural and functional studies / Julia R. Davies, Claes Wickstrom, and David J. Thornton -- Detecting, visualising, and quantifying mucins / Ceri A. Harrop, David J. Thornton, and Michael A. McGuckin -- Mass spectrometric analysis of mucin core proteins / Mehmet Kesimer and John K. Sheehan -- O-glycoprotein biosynthesis : site localization by edman degradation and site prediction based on random peptide substrates / Thomas A. Gerken -- Analysis of assembly of secreted mucins / Malin E.V. Johansson and Gunnar C. Hansson -- MUC1 membrane trafficking : protocols for assessing biosynthetic delivery, endocytosis, recycling, and release through exosomes / Franz-Georg Hanisch [and others] -- Glycomic work-flow for analysis of mucin o-linked Oligosaccharides / Catherine A. Hayes [and others] -- O-glycomics : profiling and structural analysis of mucin-type o-linked glycans / Isabelle Breloy -- O-glycoproteomics : site-specific o-glycoprotein analysis by CID/ETD electrospray ionization tandem mass spectrometry and top-down glycoprotein sequencing by in-source decay MALDI mass spectrometry / Franz-Georg Hanisch -- Analysing mucin degradation / Stephen D. Carrington [and others] -- Assessment of mucus thickness and production in situ / Lena Holm and Mia Phillipson -- Preservation of mucus in histological sections, immunostaining of mucins in fixed tissue, and localization of bacteria with FISH / Malin E.V. Johansson and Gunnar C. Hansson -- Ex vivo measurements of mucus secretion by colon explants / Jenny K. Gustafsson, Henrik Sjovall, and Gunnar C. Hansson -- Establishment of respiratory air-liquid interface cultures and their use in studying mucin production, secretion and function / David B. Hill and Brian Button -- Studying mucin secretion from human bronchial epithelial cell primary cultures / Lubna H. Abdullah [and others] -- Assessment of intracellular mucin content in vivo / Lucia Piccotti, Burton F. Dickey, and Christopher M. Evans -- Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo / Yong H. Sheng [and others] -- Assessing mucin expression and function in human ocular surface epithelia in vivo and in vitro / Pablo Argueso and Ilene K. Gipson.
  • 2013 Future Med
    Burchell, Joy M.; Taylor-Papadimitriou, Joyce.
    Mucins and cancer / Joyce Taylor-Papadimitriou & Joy M. Burchell -- Introduction to mucins in cancer / Michael A. McGuckin -- Changes in mucin-type O-linked glycosylation in cancer / Joy M. Burchell & Joyce Taylor-Papadimitriou -- Mucins as biomarkers in cancer / Kowa Chen, Ola Blixt & Hans H. Wandall -- Signaling from membrane mucins / Tze Wei Poh & Sandra J. Gendler -- MUC4 and membrane receptors in cancer / Kermit L. Carraway & Coralie A. Carothers Carraway -- MUC16, alias CA125 and ovarian cancer / Evangelia-Ourania Fourkala, Aleksandra Gentry-Maharaj & Usha Menon -- Mucins in metastasis / Sylvain Julien -- How mucins shape antigen-presenting cells to modify immune responses / Sandra J. van Vliet & Yvette van Kooyk -- MUC1 as a therapeutic target in cancer / Jean-Marc Limacher & Bruce Acres -- Index.
  • 2007 Springer
    Kaetzel, Charlotte Slayton.
  • 2006 Springer
    Tyring, Stephen K.
    The role of mucosal immunity in protection against viral diseases / Vandana Madkan, Karan Sra, and Stephen K. Tyring -- Anogenital mucosal immunology and virology / Anthony Simmons -- Gastrointestinal mucosal immunology / David A. Bland, Carlos A. Barrera, and Victor E. Reyes -- Virology of the gastrointestinal tract / Richard L. Ward ... [et al.] -- Oral manifestations of viral diseases / Denis P. Lynch -- Common respiratory viruses and pulmonary mucosal immunology / David B. Huang -- Ophthalmic manifestations of viral diseases / Steven Yeh and Mitchell P. Weikert.
  • 2013 Springer
    Prince, Alice.
    In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
  • 2005 ScienceDirect
    Lamm, Michael E.; McGhee, Jerry R.; Mestecky, Jiri.
    Also available: Print – v. 1-2, 2005.
  • 2012 Springer
    Kozlowski, Pamela A.
    Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
  • 2010 Springer
    Reichenbach, Andreas; Bringmann, Andreas.
    Introduction -- Basic properties of Müller cells -- Müller cell gliosis -- Müller cells in the healthy retina -- Retinal Development -- Müller cells as 'light cables' -- Soft Müller cells as shock absorbers and axon paths -- 'Metabolic symbiosis' -- Neurotransmitter recycling -- Retinal K+ homeostasis -- Retinal water homeostasis -- Other interactions -- Müller cells in the diseased retina -- Retinal detachment -- Diabetic retinopathy -- Macular edema -- Proliferative retinopathies -- Ischemia-reperfusion -- Hepatic retinopathy -- Retinoschisis -- Retinitis pigmentosa and support of neuronal survival -- Future directions -- Index.
  • v.1-2, 2011 Springer
    v.2 (2011) Springer
    El-Baz, Ayman S.
  • 2008
    Sigalov, Alexander B.
    T-cell receptor / Jose M. Rojo, Raquel Bello and Pilar Portolés -- B-cell receptor / Randall J. Brezski and John G. Monroe -- FC receptors / Maree S. Powell and P. Mark Hogarth -- Natural killer cell receptors / Roberto Biassoni -- Platelet glycoprotein VI / Stephanie M. Jung and Masaaki Moroi -- Clustering models / Wolfgang W.A. Schamel and Michael Reth -- Segregation models / Elaine P. Dopfer ... [et al.] -- Kinetic proofreading model / Byron Goldstein ... [et al.] -- Serial triggering model / Jacob Rachmilewitz -- Conformational model / Ruth M. Risueño, Angel R. Ortiz, and Balbino Alarcón -- Permissive geometry model / Susana Minguet and Wolfgang W.A. Schamel -- Signaling chain homooligomerization (SCHOOL) model / Alexander B. Sigalov -- Visualization of cell-cell interaction contacts : synapses and kinapses / Michael L. Dustin -- Visualization of protein interactions in living cells / Tomasz Zal -- Immunogenicity in peptide-immunotherapy : from self/nonself to similar/dissimilar sequences / Darja Kanduc -- Therapeutic application of transmembrane T and natural killer cell receptor peptides / Nicholas Manolios ... [et al.] -- FC receptor targeting in the treatment of allergy, autoimmune diseases and cancer / Akira Nakamura, Tomohiro Kubo and Toshiyuki Takai -- Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease / Joseph R. Podojil, Danielle M. Turley, and Stephen D. Miller -- MHC and MHC-like molecules : structural perspectives on the design of molecular vaccines / Vasso Apostolopoulos, Eliada Lazoura and Minmin Yu -- SCHOOL model and new targeting strategies / Alexander B. Sigalov -- Immune receptor signaling, aging and autoimmunity / Anis Larbi, Tamas Fülöp and Graham Pawelec -- Viral pathogenesis, modulation of immune receptor signaling and treatment / Walter M. Kim and Alexander B. Sigalov.
  • v. 1-2, 2014 CRCnetBASE
    v. 2, 2014 CRCnetBASE
    Saba, Luca; Suri, Jasjit S.
    [Vol. 1] Principles, head, neck, and vascular systems -- [vol. 2] Abdomen, pelvis and CAD applications.
  • 2005 Springer
    Marchal, Guy.
  • 2005 Springer
    Catalano, C.; Passariello, R.
  • 2006 Springer
    Aldrich, J. E.; Schoepf, U. J.
  • 2007 CRCnetBASE
    Nishisato, Shizuhiko.
  • 2001 CRCnetBASE
    Cox, Trevor F.; Cox, Michael A. A.
  • 2015 Springer
    Donini, Lorenzo Maria; Lenzi, Andrea; Migliaccio, Silvia.
    This book describes in detail the multidisciplinary management of obesity, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical exercise, psychological issues, nutritional strategies, pharmacological options, and bariatric surgery. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of obesity, which has rapidly become a major public health problem.
  • 2012 Springer
    Gao, Zhong-Shan.
    Part I. General Allergy. Prevalence of Allergic Diseases in China / Huan Qian, Min Zheng -- Mechanism of Type I Hypersensitivity / Cheng Zhou -- Multidisciplinary Approaches to Allergy Prevention / Luud J.W.J. Gilissen, Zhong-Shan Gao, Zhi Chen -- Part II. Allergenic Sources and Allergens. Overview of Allergen Sources in China / Zhao-Wei Yang, Zhong-Shan Gao, Ying-Tao Ma [and others] -- Allergen Protein Families and Cross-Reactivity / Luud J.W.J. Gilissen, Zhong-Shan Gao -- Seafood Allergens in China and Anti-allergenic Property of Seaweeds / Zhen-Xing Li, Hong Lin -- Food Allergen Epitopes / Hong-Bing Chen, Jin-Yan Gao -- Recombinant Allergens and Applications / Ying-Tao Ma, Zhao-Wei Yang, Zhong-Shan Gao -- Part III. Diagnosis. The CREATE Project: Development of Certified Reference Materials for Allergenic Products and Validation of Methods for Their Quantification / R. van Ree, M.D. Chapman, F. Ferreira [and others] -- Diagnosis of Skin Allergy Diseases / Huan Qian, Min Zheng -- Novel Approaches for the In-Vitro Diagnosis of Type I Allergies / Margrit Fooke -- Influence of Food Processing, Digestion and the Food Matrix on Allergenicity & Cellular Measures of Allergenicity / Y.M. Vissers, H.J. Wichers, H.F.J. Savelkoul -- Part IV. Therapies and Pharmacy. Immunotherapy of Asthma: From Basic Research to Clinical Practices / Hui-Ying Wang, Hua-Hao Shen -- Pharmacotherapy in Common Allergic Diseases / Erina M. Lin -- Immunotherapy in Allergic Skin Disease / Hao Cheng -- Traditional Chinese Medicine for Treating Food Allergy and Associated Eczema: From Research to Practice Perspective / Xiu-Min Li -- Immunomodulation by Food / Ingrid van der Meer, Jurriaan Mes, Amrah Weijn, Harry Wichers -- Prospective Studies on Mite (Dermatophagoides farinae) Allergen Immunotherapy in China / Ting-Huan Wen -- The Influence of Pollen Concentration on the Dispension of Antihistaminics and Corticosteroids to Hay Fever Patients / Arnold J.H. van Vliet, Hilde Tobi -- Part V. Hypoallergenic Products. In Search of Hypoallergenic Birch Trees: Characterization of PR-10 Genes from Eight Betula Species and Detection of Bet v 1 Isoforms in Birch Pollen Using a Combined Genomics- Proteomics Approach / M.J.M. Smulders, Martijn F. Schenk, Luud J.W.J. Gilissen -- Hypoallergenic Soybean, from Genes to Cultivar / Rong-Xia Guan, Xu-Qian Fang, Ru-Zhen Chang, Li-Juan Qiu -- Fruit Allergy and Genetic and Genomic Tools to Select Hypoallergenic Fruit Cultivars / Zhong-Shan Gao, Zhao-Wei Yang, Luud Gilissen -- Creating Hypoallergenic Crops through Genetic Modification / Xing-Jun Wang, Han Xia, Shuan-Tao Liu [and others] -- Acceptance of Natural and Genetically Modified Hypoallergenic Apples by Consumers with an Oral Allergy Syndrome (OAS) / I.M. van der Meer, M.F. Schenk, A.R.H. Fischer [and others] -- Cow's Milk Allergens and Technologies to Control Allergenicity / Yong-Kang Luo, Guan-Hao Bu -- Part VI Environment, Hygiene and Societal Issues. Prevalence of Asthma and Asthmatic Symptoms in Children in Relation to Environmental Factors --Epidemiological Studies in School Children in Taiyuan, China / Zhuo-Hui Zhao, Zhuan-Hua Wang, Zheng Zhang [and others] -- The Relationship of Food Allergies and Respiratory Allergies in Urban and Rural Chinese Children / Gary W.K. Wong, Yu-Zhi Chen, Jing Li, Nan-Shan Zhong -- Socio-Economic Issues Associated with Food Allergy / L.J. Frewer, J. Voordouw, M.F. Schenk [and others] -- The Association between Helminth Infections and Atopic Diseases / L.A.H. Hermsen.
  • 2006 ScienceDirect
    McNamara, Laura A.; Paton, Ray.
  • 2013 Springer
    Chan, Lewis; Tse, Vincent.
    Multidisciplinary Care of Urinary Incontinence - a Handbook for Health Professionals effectively uses a multidisciplinary approach to assist health professionals in their care of patients with urinary incontinence. It is recognized that the best outcomes are achieved by a multidisciplinary team approach especially with regard to complex cases and care of the elderly. This book is written by expert authors from around the world with a wealth of experience in conducting clinics on pelvic floor, aged care voiding dysfunction and neuro-rehabilitation. The text is illustrated throughout and contains case-studies with input and practical tips from the different health disciplines at each point. Each chapter concludes with a list of seminal publications and web-based resources to assist the reader in the clinical environment. Multidisciplinary Care of Urinary Incontinence - a Handbook for Health Professionals is of benefit to medical and allied health disciplines including family physicians, nurses, urologists, gynecologists, physiotherapists, geriatricians, neurologists and rehabilitation specialists.
  • 2016 Springer
    Conwell, Darwin L.; Guy, Gregory E.; Hazey, Jeffrey W.
    1. Historical perspectives and treatments for common bile duct stones -- 2. Common bile duct stones: health care problem and incidence -- 3. Bile duct stones: making the radiologic diagnosis -- 4. Making the diagnosis: gastroenterology -- 5. Making the diagnosis: surgery, a rational approach to the patient with suspected CBD stones -- 6. Percutaneous biliary access: considerations, techniques, and complications -- 7. Special considerations for the gastroenterologist -- 8. Special considerations for teh surgeon -- 9. Percutaneous methods of common bile duct stone retrieval -- 10. Gastroenterologic treatment and outcomes -- 11. Surgical treatment and outcomes -- 12. Surgical procedures to prevent recurrence -- 13. Mangement of medical complications of gallstone disease -- 14. Managment of surgical complications -- 15. Special considerations: management of common bile duct strones in the bariatric patient -- 16. Management of choledocholithiasis in the cirrhotic patient -- 17. Nonprocedural management of common bile duct stones -- Index.
  • 2014 Springer
    Gentile, Vincenzo; Panebianco, Valeria; Sciarra, Alessandro.
    Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such a multidisciplinary approach within a specialized unit involves a variety of specialists, including urologists, oncologists, radiotherapists, radiologists and pathologists. This book describes in detail the advantages of multidisciplinary management of prostate cancer. It opens by explaining the nature of the required multidisciplinary team and the potential benefits of the prostate cancer unit as a structure for the delivery of specialist multidisciplinary care. Epidemiological aspects favoring multidisciplinary management are described and each element of care within the context of the prostate cancer unit is then discussed; also has been described the role of advanced imaging (Multiparametric MRI) in the management of PCa. Early diagnosis, risk classification, treatment decision making, surgery, radiotherapy, medical therapies and health care support are all fully considered. This book will be informative and enlightening for all who are involved in the management of patients with prostate cancer.
  • 2013 Springer Protocols
    Nguyen, Peter V.
    Conditional Gene Targeting: A Refined Method for Genetic Studies in Neurosciences -- Sindbis Virus-Mediated In Vivo Expression of Recombinant CREB to Study Gene Function in Neuronal Plasticity and Behavior -- Exploring Mechanisms of Synaptic Plasticity Using Exogenous Expression of Proteins at the Sensory-to-Motor Neuron Synapse of Aplysia -- Translational Regulation of Synaptic Plasticity -- Glutamate Receptors and Synaptic Physiology in Developing Neural Circuits -- Laminar Quantification of Dendrites in Dentate Gyrus Granule Neurons -- Electrophysiological and Biochemical Studies of AMPA Receptor Phosphorylation and Synaptic Plasticity in Hippocampal CA1 Mini-Slices -- Electrophysiological and Behavioral Approaches to the Analysis of Synaptic Tagging and Capture -- Intracellular Loading and Rapid Calcium Imaging in Processes of Hippocampal Astrocytes -- Electrophysiological Methods for Investigating Inhibitory Synaptic Plasticity -- Converging Methodologies in a Mammalian 'Simple System' Focused on the Biology of Memory: Conditioned Odor Preference in the Neonate Rat -- The Sagittally-Sectioned Rat Hindbrain Preparation: Improved Access to the Brainstem Respiratory Network.
  • 2015 Springer
    Baatrup, Gunnar.
    This book is intended as the equivalent of the Swiss Army knife for all members of colorectal cancer (CRC) multidisciplinary teams and those training in the fields of CRC management. It describes how to organize the team and explains the basic principles within the different disciplines involved in the treatment and care of CRC patients. Important, up-to-date knowledge is provided on visualization techniques, surgery, oncological treatment, palliation, and pathology, with special focus on controversies and aspects of interest to all team members. Care has been taken to ensure that each specialty-specific chapter will be approachable for team members from other specialties or professions, thereby facilitating an effective interdisciplinary approach to teamwork. The authors include leading European doctors and scientists who have influenced the development of the multidisciplinary team concept as well as other aspects of high-quality, individualized treatment of CRC patients.
  • 2013 Springer
    Brouquet, Antoine; Vauthey, Jean-Nicolas.
    It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.
  • 2014 Springer
    Alió, Jorge L.; Pikkel, Joseph.
    This book provides the practising ophthalmologist and surgeon with up-to-date information on the use of multifocal intraocular lenses to eliminate pseudophakic presbyopia. Guidance is provided on types and models of intraocular lens, indications, selection of patients, implantation, neuroadaptation, and complications and their avoidance. A key goal is to enable the practitioner to select the best lens for the individual patient, taking into account special circumstances. In addition, the results achieved to date with different lenses are analyzed and advice is given on the management of expectations. The authors are acknowledged international experts who draw upon their own experience and the peer-reviewed literature to provide the practitioner with cutting-edge information and evidence-based guidance.
  • 2011
    Sherlock, Sarah Paige; Dai, Hongjie; Pecora, Robert; Zare, Richard N.
    In recent years there has been a growing interest in utilizing nanomaterials for drug delivery and biomedical imaging applications. This work focuses on the development of two multifunctional graphitic-carbon based nanomaterials capable of acting as both drug delivery agents and as contrast agents for either magnetic resonance imaging or near-infrared fluorescence imaging. Both of these agents heat under near-infrared light and are capable of loading chemotherapy drugs making them multifunctional in nature. The first material discussed is a FeCo-graphitic carbon nanocrystal loaded with doxorubicin. Addition of near-infrared photothermal therapy significantly increases the cellular toxicity of these nanocrystals in vitro. Treatment of breast cancer tumors in mice using combined nanocrystal drug delivery and photothermal therapy resulted in complete tumor regression in 45% of mice. The imaging capability of these nanocrystals is demonstrated through high-resolution magnetic resonance imaging of microvessels in rabbits. The potential long-term biodistribution and safety of this material is evaluated. The second graphitic-carbon nanomaterial used in this work is single-walled carbon nanotubes. This material is developed as a deep-tissue fluorescent imaging agent due to their inherit photoluminescence beyond 1 micron. This light emission is demonstrated to be particularly useful for in vivo imaging by minimizing light scattering by tissues leading to crisp anatomical resolution.
  • 2008 Springer
    Torchilin, Vladimir P.
  • 2006 Springer
    Bent, Elizabeth; Tuzun, Sadik.
  • Khan, Latifur; Petrushin, V. A.
  • 2011 AccessMedicine
    Pahlm, O.; Wagner, Galen S.
    Current methods and their applications for cardiovascular multimodal imaging -- Echocardiography -- Phonocardiography -- Myocardial perfusion single photon emission computed tomography and positron emission tomography -- Coronary angiography -- Cardiac computed tomography -- Cardiac magnetic resonance imaging in ischemic heart disease -- Electrocardiography of ischemic heart disease -- Electrophysiologic mapping -- Nuclear cardiology applied to electrophysiology -- Optical mapping of electrical activity -- Dipolar electrocardiotopography imaging -- Foundations of future methods for cardiovascular multimodal imaging -- Electrocardiographic imaging of epicardial potentials -- Electromechanical modeling applied to cardiac resychronization therapy -- Computational cardiac electrophysiology: modeling tissue and organ -- Cardiac simulation for education: the electrocardiogram according to ECGSIM -- Graphical analysis of heart rate patterns to access cardiac autonomic function -- Development of the heart, with particular reference to the cardiac conduction tissues -- Cardiovascular multimodal imaging in key clincial problems -- Congenital heart disease: atrioventricular septal defect -- Right ventricular cardiomyopathies -- Ischemic heart disease -- Acute myocardial infarction -- Diseases of the aorta -- Peripheral vascular disease -- Pulmonary vascular disease -- Atrial fibrillation.
  • 2006 Springer
    Brown, J. M.; Mehta, Minesh P.; Nieder, C.
    Also available: Print – 2006
  • 2008
    Müller, Hans-Peter; Kassubek, Jan.
  • 2014 Springer
    Pedro, Luís Mendes; Saba, Luca; Sanches, João Miguel; Suri, Jasjit S.
    Stroke is one of the leading causes of death in the world, resulting mostly from the sudden ruptures of atherosclerosis carotid plaques. Understanding why and how plaque develops and ruptures requires a multi-disciplinary approach such as radiology, biomedical engineering, medical physics, software engineering, hardware engineering, pathological and histological imaging. Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment presents a new dimension of understanding Atherosclerosis in 2D and 3D. This book presents work on plaque stress analysis in order to provide a general framework of computational modeling with atherosclerosis plaques. New algorithms based on 3D and 4D Ultrasound are presented to assess the atherosclerotic disease as well as very recent advances in plaque multimodality image fusion analysis. The goal of Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment is to fuse information obtained from different 3D medical image modalities, such as 3D US, CT and MRI, providing the medical doctor with some sort of augmented reality information about the atherosclerotic plaque in order to improve the accuracy of the diagnosis. Analysis of the plaque dynamics along the cardiac cycle is also a valuable indicator for plaque instability assessment and therefore for risk stratification. 4D Ultrasound, a sequence of 3D reconstructions of the region of interest along the time, can be used for this dynamic analysis. Multimodality Image Fusion is a very appealing approach because it puts together the best characteristics of each modality, such as, the high temporal resolution of US and the high spatial resolutions of MRI and CT.
  • 2010 Thieme Book
    Hashimoto, Beverly.
  • 2013 Springer
    Berman, Daniel S.; Leipsic, Jonathon; Min, James K.
    Over the last decade, remarkable innovations in transcatheter technologies have led to the rapid development of minimally invasive therapies that have challenged conventional treatment. Amongst these, none is as remarkable as transcatheter aortic valve replacement (TAVR). An archetype of bench-to-bedside medicine, the origins of TAVR spanned the expertise and vision of clinicians, engineers, researchers and imagers. With increasing numbers of TAVR procedures and large-scale trials demonstrating an unparalleled reduction in mortality for inoperable patients with severe aortic valvular disease, the theme underpinning the foundation of TAVR that of a multidisciplinary approach to its development persists in its practice. This approach brings together a diverse group of experts to optimize patient outcomes and this extends to the convergence of different types of imaging specialists and modalities to support preparation for and performance and follow-up of TAVR. Multimodality Imaging for Transcatheter Aortic Valve Replacement assembles the very best authorities in the field to create the ultimate resource to address the imaging needs associated with TAVR. It provides the reader with a comprehensive understanding of the pathophysiology of aortic stenosis, the evidence supporting the use of TAVR, and an integrated approach to the indications, procedural aspects and pitfalls of imaging in TAVR. The reader will also gain an insight into which tests are optimal in specific situations and a step-wise method to harvest all the essential information provided with each modality. Thus, this book represents a key resource for all working in the field whether they be in training or practicing physicians, cardiac researchers, cardiac imagers, interventionalists, clinical cardiologists, cardiac surgeons, or any medical professional involved in the management of these patients.
  • 2016 Springer
    Ahmad, Syed A.; Katz, Matthew H. G.
    Anatomic Definitions of Borderline Resectable Pancreatic Cancer -- Imaging Evaluation of Borderline Pancreatic Cancer -- Endoscopic Ultrasonography: Staging and Therapeutic Intervention -- Endoscopic and Percutaneous Biliary Drainage Procedures: Role in Preoperative Management, Diagnosis, and Palliation -- Overview of Multimodality Therapy -- Role of Systemic Therapy -- Role of Radiation Therapy -- Stereotactic Body Radiation Therapy as an Emerging Option for Localized Pancreatic Cancer -- Assessment of Response to Preoperative Therapy -- Emerging Systemic and Targeted Therapies -- Operative Principles in Managing Patients with Borderline Resectable Pancreas Cancer -- Is There a Role for Laparoscopic and/or Robotic Techniques for Borderline Resectable Tumors?. Role and Techniques Of Vascular Resection -- Artery-First Approaches to Pancreaticoduodenectomy -- Venous Shunting Procedures for Borderline Resectable Pancreatic Cancer -- The Role of the Appleby Operation and Arterial Resection in the Multimodality Management of Borderline Resectable Pancreatic Cancer -- Surgery for Borderline Resectable Pancreatic Cancer: The Japanese Experience -- The Role of Irreversible Electroporation and Other Ablative Techniques in Patients with Borderline Resectable Pancreatic Cancer -- Surgical Approach to Borderline Resectable tumors of the Left Pancreas -- Palliative Operations for Unresectable Pancreatic Cancer.
  • 2010
    Toytman, Ilya; Bucksbaum, Philip H.; Harris, S. E.; Palanker, Daniel.
    Ultrafast lasers offer an advantage of highly localized interactions with transparent materials due to non-linearity of multiphoton processes with laser intensity. Biological and medical applications of these interactions can be nominally divided into two classes: (1) diagnostic imaging and spectroscopy and (2) plasma-mediated surgery. Imaging techniques, such as multiphoton fluorescence, harmonic generation, and stimulated Raman scattering typically employ relatively low power laser sources to avoid damage to the specimens. Surgical applications, on the other hand, rely on formation of plasma at the focus of high peak power laser beam. Current paradigm in applications of multiphoton interactions is based on scanning of a focused beam within the sample in order to image extended areas or produce long cuts point-by-point. We demonstrate several optical systems based on a new paradigm -- distributed multiphoton interactions, where the scanning is reduced or even not required at all. In the area of diagnostic imaging, we have developed and successfully tested a wide-field Coherent Anti-Stokes Raman Scattering (CARS) microscopy technique, which is based on simultaneous imaging of the extended area of the sample. The signal generation relies on the non-phase-matching illumination, and the image acquisition is performed from the entire illuminated area without scanning, using an array detector. We have characterized the spatial and spectral resolution of the method, and demonstrated its chemical selectivity. Optimization of the illumination geometry and proper selection of the wavelengths of the pump and Stokes beams allowed acquisition of the myelin-specific images of nerve tissue with diffraction-limited spatial resolution of 0.5μm. Single-shot imaging capability has been demonstrated on a test sample of polystyrene beads. In surgical applications of ultrafast lasers the extent of the rupture zone in tissue is often determined by dynamics of cavitation bubble resulting from the optical breakdown. Typically tissue cutting is performed point-by-point using a scanning laser. We have studied the possibilities of enhancing the cutting efficiency using two methods. First approach is based on hydrodynamic interactions between two simultaneously created bubbles. A theoretical model of the flow induced by the cavitation bubbles was developed and experimentally verified. Based on experimentally measured rupture threshold strain of a material we derived the shape of the rupture zone for a given distance between the focal spots. We have found that for the threshold strain of 0.7, a continuous cut is 1.35 longer than the one produced by two bubbles applied sequentially. This ratio increases up to 1.7 if a linear series of multiple bubbles is applied simultaneously. Counter-propagating liquid jets forming during collapse of two bubbles in inviscid liquid can increase the rupture zone up to a factor of 2.5. Alternative approach to extending the cutting zone in transparent tissue is based on generation of optical breakdown in a highly elongated zone. By focusing a picosecond laser pulse with a combination of a lens and an axicon we have obtained breakdown zone with aspect ratio of 250:1. The axial intensity distribution was analyzed based on the shape of the resulting cavitation bubble, and was further confirmed by numerical evaluation of a Fresnel diffraction integral. We have optimized the incident laser beam profile to obtain uniform intensity along the breakdown region and to minimize the amount of energy deposited into the sample. We also demonstrate dielectric breakdown and associated cavitation with adjustable length and axial position controlled by modulation of the laser beam profile using an amplitude mask.
  • 2013 Springer
    Gupta, Rajesh; Patel, Dilip.
    Interest in regional anaesthesia has been flourishing for a number of reasons, including in particular the feasibility of ultrasound-guided peripheral nerve blocks. This trend is reflected in the growing popularity of fellowships in regional anaesthesia. The syllabus for such fellowship examinations is vast, and this book aims to provide suitable guidance by presenting typical multiple choice questions with accompanying answers, in detail when necessary. The entire syllabus is covered in four comprehensive sections that address basic principles and equipment, peripheral nerve blocks, central neuraxial blocks, and regional anaesthesia and acute pain. Multiple Choice Questions in Regional Anaesthesia will be especially useful for those preparing for European Society of Regional Anaesthesia diploma examinations or for the regional anaesthesia component of FRCA examinations. It is also highly relevant to equivalent U.S. and Canadian examinations and will be helpful to all who require a self-assessment tool in the subject.
  • 2006 CRCnetBASE
    Blasius, Jorg; Greenacre, Michael J.
  • 2013 Springer
    Fanelli, Gregory C.
    A reference suitable for orthopedic surgeons, trauma surgeons, sports medicine fellows, orthopedic surgery residents, physical therapists, physician assistants, and all health professionals who treat traumatic injuries of the knee. Vastly expanded from its first publication, new topics in this edition include: -ACL based multiple ligament knee injury-Mechanical graft tensioning-Fracture dislocations-Articular cartilage restoration-Meniscus transplantation-Extensor mechanism restoration. Hundreds of illustrations and photographs facilitate easy comprehension of the text. Covering everything from anatomy and biomechanics through diagnosis, classification, both non-surgical and surgical management, complications and selected case studies, gives a complete picture of a complex pathologic entity.
  • 2011 Springer
    Goldschmidt, Hartmut; Moehler, Thomas.
    Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
  • 2005 Springer Protocols
    Brown, Ross D.; Ho, P. Joy.
    Identification of malignant plasma cells by mRNA in situ hybridization / Ross D. Brown and P. Joy Ho -- The SCID-hu myeloma model / Joshua Epstein and Shmuel Yaccoby -- The 5T2MM murine model of multiple myeloma: maintenance and analysis / Karin Vanderkerken ... [et al.] -- Determination of telomerase activity and telomere length / Kai-da Wu and Malcolm A.S. Moore -- Dendritic cell/myeloma hybrid vaccine / Dajing Xia, Tim Chan, and Jim Xiang -- Genetically engineered myeloma cell vaccine / Siguo Hao, Tim Chan, and Jim Xiang -- An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors / Andrew C.W. Zannettino ... [et al.] -- Clonality detection of the expanded T-cell populations in patients with multiple myeloma / Daniel M-Y. Sze -- Detecting mismatch repair defects in myeloma / Mark Velangi ... [et al.] -- Methylation-specific polymerase chain reaction / Oliver Galm and James G. Herman -- Making sense of DNA microarray data / Wei-min Liu, Sunhee K. Ro, and Walter H. Koch. Multiple myeloma: challenges and opportunities / Douglas Joshua, Ross D. Brown, and P. Joy Ho -- Immunophenotyping of plasma cells in multiple myeloma / Gema Mateo Manzanera, Jesús F. San Miguel Izquierdo, and Alberto Orfao de Matos -- Plasma cell labeling index / Philip R. Griepp and Shaji Kumar -- Conventional cytogenetics in myeloma / Lynda J. Campbell -- Multicolor spectral karyotyping in multiple myeloma / Jeffrey R. Sawyer -- Detection of chromosome 13 deletions by fluorescent in situ hybridization / Scott VanWier and Rafael Fonseca -- Comparative genomic hybridization for analysis of changes in DNA copy number in multiple myeloma / Pulivarthi H. Rao -- Southern blotting of IgH rearrangements in B-cell disorders / Edna Yuen and Ross D. Brown -- Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma / Surinder S. Sahota, Mark Townsend, and Freda K. Stevenson -- Identification of clonotypic IgH VDJ sequences in multiple myeloma / Brian J. Taylor ... [et al.] -- Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in myeloma / Mara Compagno ... [et al.] -- Incomplete DJH rearrangements / David González and Ramón Garcia-Sanz ...
  • 1973-
    Azar, Henry A.; Potter, Michael.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Gertz, Morie A.; Rajkumar, S. Vincent.
    This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care.
  • 2013 Springer
    Christen, Yves; Pfaff, Donald W.
    In theoretical terms, sex differences in brain and behavior offer the possibility of fascinating scientific studies on a range of molecular phenomena such as DNA methylation, chromatin protein modification, non-coding DNA, resulting in important neuroanatomical and neurochemical effects. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present where they did not really exist, e.g. with respect to mathematics, executive leadership, etc. etc. Under what circumstances do we really care about sex differences in brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men. Prominent examples to be discussed today will include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia. The meeting will end with a consideration of effects of estrogenic hormones on the injured brain, and their roles as protective agents.
  • 2009 Springer
    Renda, Andrea.
  • 2013
    Rodriguez, Moses; Kantarci, Orhun H.; Pirko, Istvan.
    Status: Not Checked OutLane Catalog Record
    The spectrum and diagnosis of multiple sclerosis / Orhun H. Kantarci -- The differential diagnosis of multiple sclerosis / Orhun H. Kantarci -- The epidemiology, genetics, environment, and natural history of multiple sclerosis / Orhun H. Kantarci -- The role of magnetic resonance imaging in multiple sclerosis / Istvan Pirko -- Neuropathology : clues to pathogenesis / Moses Rodriguez -- What has immunology taught us about multiple sclerosis? / Moses Rodriguez -- Neural degeneration and potential novel treatments / Moses Rodriguez -- Treatment of acute exacerbations of multiple sclerosis / Istvan Pirko -- Disease-modifying therapies in multiple sclerosis / Istvan Pirko -- Managing symptoms of multiple sclerosis / Orhun H. Kantarci -- Upcoming therapies / Istvan Pirko -- Treatment to promote remyelination / Moses Rodriguez.
  • 2005 Springer
    Olek, Michael J.
    Signs and symptoms of multiple sclerosis / Stanley van den Noort -- Differential diagnosis, clinical features, and prognosis of multiple sclerosis / Michael J. Olek -- Role of magnetic resonance imaging in the diagnosis and prognosis of multiple sclerosis / Robert Zivadinov and Rohit Bakshi -- Cognitive dysfunction in multiple sclerosis / Darcy Cox and Laura Julian -- Multiple sclerosis, genetics, and autoimmunity / Michael Demetriou -- B-cell immunology in multiple sclerosis / Yufen Qin and Pierre Duquette -- Multiple sclerosis : a case for early treatment / Alex C. Tselis and Omar A. Khan -- Pregnancy and multiple sclerosis / Christina Caon -- Treatment of progressive multiple sclerosis / Norman Wang -- Cyclophosphamide therapy for multiple sclerosis / Derek R. Smith -- Repair and neuroprotective strategies in multiple sclerosis / Fernando Dangond -- Future therapies / Michael J. Olek.
  • 2006
    Freedman, Mark.
  • 2014 ScienceDirect
    Goodin, Douglas S.
    Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology.
  • 2005 ScienceDirect
    Waxman, Stephen G.
    Structure, molecular organization, and function of myelinated axons -- Neuronal concomitants of demyelination -- Multiple sclerosis as a neurodegenerative disease -- Measurement of neuronal changes in the clinical domain -- Cellular and molecular mechanisms of axonal degeneration in multiple sclerosis -- Other aspects of neuronal injury in multiple sclerosis -- Lessons from the peripheral nervous system -- Prognosis, reparative mechanisms, and therapeutic approaches.
    Also available: Print – 2005
  • 2013 Springer
    Gran, Bruno; Yamamura, T.
    The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the "new" MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and-even more-the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that "translation" is real and not just virtual.
  • 1962/9999
    Gudmundsson, Kjartan R.; Gudmundsson, Gunnar.
  • 2015 Springer Protocols
    Weissert, Robert.
    Positional gene cloning in experimental populations / Maja Jagodic and Pernilla Stridh - - Generation of transgenic rats using lentiviral vectors / Holger M. Reichard and Henrike J. Fischer -- DNA vaccination techniques / Nicolas Fissolo, Xavier Montalban, and Manuel Comabella -- Peripheral blood mononuclear cells : isolation, freezing, thawing, and culture / Christine Riedhammer, Dagmar Halbritter, and Robert Weissert -- ELISPOT techniques / Niannian Ji and Thomas G. Forsthuber -- Isolation of central nervous system (CNS) infiltrating cells / Ilgiz A. Mufazalov and Ari Waisman -- Methods for ex vivo analysis of immune cell function from the central nervous system / Darryl G. Turner ... [et al.] -- Neurofilament light chain determination from peripheral blood samples / Marguerite Limberg ... [et al.] -- Detection of autoantibodies against myelin oligodendrocyte glycoprotein in multiple sclerosis and related diseases / Melania Spadaro and Edgar Meinl -- Myelinating cultures : an in vitro tool to identify demyelinating and axopathic autoantibodies / Maren Lindner and Christopher Linington -- In vivo visualization of (auto-) immune processes in the central nervous system of rodents / Christian Schlager ... [et al.] -- Optical coherence tomography to assess neurodegeneration in multiple sclerosis / Axel Petzold -- Experimental autoimmune encephalomyelitis in mice / Rachael L. Terry, Igal Ifergan, and Stephen D. Miller -- Actively induced experimental autoimmune encephalomyelitis in rats / Robert Weissert -- Experimental autoimmune encephalomyelitis in marmosets / S. Anwar Jagessar ... [et al.]-- Neuropathological techniques to investigate CNS pathology in experimental autoimmune encephalomyelitis (EAE) / Karin Steinbach and Doron Merkler -- Neuropathological techniques to investigate central nervous system sections in multiple sclerosis / Jan Bauer and Hans Lassmann.
  • 2013 CRCnetBASE
    Finlayson, Marcia.
    "This edited handbook provides a comprehensive resource to inform and guide health and rehabilitation practitioners as they engage in the rehabilitation process with multiple sclerosis patients. The text provides a broad-based perspective on multiple sclerosis, how it influences everyday life, and the strategies that can be employed by rehabilitation practitioners to enable people with MS to fully engage in everyday life. The first section offers an overview of MS basics; the next two sections describe MS rehabilitation to manage impairments and to enhance activity and participation among MS patients; and the final section presents contextual factors that may influence MS rehabilitation efforts"--Provided by publisher.
  • 2014 Springer Protocols
    Russell, David James.
    Dynamic programming / O. Ufuk Nalbantoglu -- Heuristic alignment methods / Osamu Gotoh -- Objective functions / Haluk Dogan and Hasan H. Otu -- Who watches the watchmen? An appraisal of benchmarks for multiple sequence alignment / Stefano Iantorno ... [et al.] -- BLAST and FASTA similarity searching for multiple sequence alignment / William R. Pearson -- Clustal omega, accurate alignment of very large numbers of sequences / Fabian Sievers and Desmond G. Higgins -- T-coffee : tree-based consistency objective function for alignment evaluation / Cedrik Magi ... [et al.] -- MAFFT : iterative refinement and additional methods / Kazutaka Katoh and Daron M. Standley -- Multiple sequence alignment using probcons and probalign / Usman Roshan -- Phylogeny-aware alignment with PRANK / Ari Loytynoja -- GramAlign : fast alignment driven by grammar-based phylogeny / David J. Russell -- Multiple sequence alignment with DIALIGN / Burkhard Morgenstern -- PicXAA : a probabilistic scheme for finding the maximum expected accuracy alignment of multiple biological sequences / Sayed Mohammad Ebrahim Sahraeian and Byung-Jun Yoon -- Multiple protein sequence alignment with MSAProbs / Yongchao Liu and Bertil Schmidt -- Large-scale multiple sequence alignment and tree estimation using SATe / Kevin Liu and Tandy Warnow -- PRALINE : a versatile multiple sequence alignment toolkit / Punto Bawono and Jaap Heringa -- PROMALS3D : multiple protein sequence alignment enhanced with evolutionary and three-dimensional structural information / Jimin Pei and Nick V. Grishin -- MSACompro : improving multiple protein sequence alignment by predicted structural features / Xin Deng and Jianlin Cheng.
  • 2014 Springer
    Fanciulli, Alessandra; Wenning, Gregor K.
    This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson's disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.
  • 2010 CRCnetBASE
    Bretz, Frank; Dmitrienko, Alex; Tamhane, Ajit C.
    1. Multiplicity problems in clinical trials : a regulatory perspective / Mohammad Huque and Joachim Rèohmel -- 2. Multiple testing methodology / Alex Dmitrienko ... [et al.] -- 3. Multiple testing in dose-response problems / Frank Bretz, Ajit C. Tamhane, and Josâe Pinheiro -- 4. Analysis of multiple endpoints in clinical trials / Ajit C. Tamhane and Alex Dmitrienko -- 5. Gatekeeping procedures in clinical trials / Alex Dmitrienko and Ajit C. Tamhane -- 6. Adaptive designs and confirmatory hypothesis testing / Willi Maurer, Michael Branson, and Martin Posch -- 7. Design and analysis of microarray experiments for pharmacogenomics / Jason C. Hsu ... [et al.].
  • 2008 Springer
    Dudoit, Sandrine; Laan, M. J. van der.
  • 2014/2014
    Ferran, Christiane.
    "This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target"--Publisher's description.
  • 2006 Springer
    Mandahar, C. L.
  • 2012
    Liu, Linda Yang; Butte, Atul J.; Stefanick, Marcia Lynn; Tibshirani, Robert.
    There are clear physiological differences between men and women, including dimorphism in disease susceptibility and treatment response. These disparities often stem from biological differences between the sexes. Sex matters at every level of biology, including genes, proteins, pathways and tissues. Sex chromosomes are fundamental determinants of genetic makeup; sex hormones regulate the expression of thousands of genes; immune response pathways differ between the sexes; and clinical variables like heart rate and pain intensity are also divergent. With current technological advances in high-throughput measurement modalities, we can simultaneously probe every gene in the genome or record millions of clinical features in databases for research. However, investigators using large-scale data sources often ignore the question of sex differences. Many experimental studies use only male animals, and clinical trials often exclude one sex in an attempt to reduce variability in their results. This has led to many pharmaceuticals failing to receive approval by the Food and Drug Administration due to toxicity or lack of efficacy in the untested sex. Rather than completely ignoring sex or viewing it only as a variable to control for, we should make sex differences research a priority of every study. In particular, we should incorporate sex analysis into large-scale genomics, proteomics and clinical analyses. In addition, integrating different types of data will enable more powerful mechanistic studies. Investigating sex differences can lead to new insights about how disease operates differently in men and women. These insights will in turn lead us closer to the goal of personalized medicine for both men and women. In this thesis, I describe methods to address informatics challenges in performing sex-differentiated analysis of high-throughput datasets. In particular, I show that I have (1) developed a novel statistical method to systematically analyze genome-wide association study data for sex differences, (2) applied the method to discover and validate a novel sex difference in a top Crohn's disease risk gene, (3) developed methods to mine large electronic medical record databases to discover sex differences in clinical pain measures, and (4) modeled sex-specific gene-gene interactions to discover molecular sex differences in Alzheimer's disease. This dissertation contains a set of methods for (1) genomics and other data-driven researchers to discover sex differences in molecular and clinical measurements and (2) sex differences researchers to integrate large-scale data sources. Many of the methods I have developed are generalizable to any situation in disease or genomics research with a binary variable of interest.
  • 2013 Springer
    Lacey, Simon; Lawson, Rebecca.
    Is a pear sweeter than a peach? Which of Mona Lisa's hands is crossed over the other? What would the Moonlight Sonata sound like played by a brass band? Although these are questions that appeal to mental imagery in a variety of sensory modalities, mental imagery research has been dominated by visual imagery. With the emergence of a well-established multisensory research community, however, it is time to look at mental imagery in a wider sensory context. Part I of this book provides overviews of unisensory imagery in each sensory modality, including motor imagery, together with discussions of multisensory and cross-modal interactions, synesthesia, imagery in the blind and following brain damage, and methodological considerations. Part II reviews the application of mental imagery research in a range of settings including individual differences, skilled performance such as sports and surgical training, psychopathology and therapy, through to stroke rehabilitation. This combination of comprehensive coverage of the senses with reviews from both theoretical and applied perspectives not only complements the growing multisensory literature but also responds to recent calls for translational research in the multisensory field.
  • 2010 Springer
    Kaiser, Jochen; Naumer, Marcus J.; Stein, Barry E.
    Corticocortical connectivity subserving different forms of multisensory convergence / M. Alex Meredith and H. Ruth Clemo -- Computational modeling of multisensory object perception / Constantin Rothkopf, Thomas Weisswange, and Jochen Triesch -- Methodological considerations : electrophysiology of multisensory interactions in humans / Marie-Hélène Giard and Julien Besle -- Cortical oscillations and multisensory interactions in humans / Jochen Kaiser and Marcus J. Naumer -- Multisensory functional magnetic resonance imaging / Marcus J. Naumer ... [et al.] -- Audiovisual temporal integration for complex speech, object-action, animal call, and musical stimuli / Argiro Vatakis and Charles Spence -- Imaging cross-modal influences in auditory cortex / Christoph Kayser, Christopher I. Petkov, and Nikos K. Logothetis -- The default mode of primate vocal communication and its neural correlates / Asif A. Ghazanfar -- Audio-visual perception of everyday natural objects - hemodynamic studies in humans / James W. Lewis -- Single-trial multisensory learning and memory retrieval / Micah M. Murray and Holger F. Sperdin -- Multisensory texture perception / Roberta L. Klatzky and Susan J. Lederman -- Dorsal and ventral cortical pathways for visuo-haptic shape integration revealed using fMRI / Thomas W. James and Sunah Kim -- Visuo-haptic perception of objects and scenes / Fiona N. Newell -- Haptic face processing and its relation to vision / Susan J. Lederman, Roberta L. Klatzky, and Ryo Kitada -- The ontogeny of human multisensory object perception : a constructivist account / David J. Lewkowicz -- Neural development and plasticity of multisensory representations / Mark T. Wallace, Juliane Krueger, and David W. Royal -- Large-scale brain plasticity following blindness and the use of sensory substitution devices / Andreja Bubic, Ella Striem-Amit, and Amir Amedi.
  • 2009
    Trunnell, Nicole Breaux; Bogyo, Matthew; Cimprich, Karlene A.; Ferrell, James Ellsworth; Stearns, Tim.
    The mitotic phosphatase Cdc25C opposes the inhibitory activity of the mitotic kinases Wee1 and Myt1 as part of a double feedback loop system that gates entry into mitosis. The substrate for both Cdc25C and Wee1 is the kinase Cdk1, which activates Cdc25C and inhibits Wee1 via hyperphosphorylation of both proteins' N-terminal regulatory regions. This work characterizes the structure, or lack thereof, of the N-terminal regulatory domain of Cdc25C through biochemical assays and NMR analysis. Furthermore, while previous evidence has shown that the response of Wee1 phosphorylation is ultrasensitive with respect to Cdk1 activity, this work demonstrates that Cdc25C is similarly hyperphosphorylated in an ultrasensitive fashion in Xenopus extract. The ultrasensitive hyperphosphorylation of Cdc25C does not depend on competition from other Cdk1 substrates and is unchanged in a diluted extract system. The response function of Cdc25C in a simplified in vitro system remains ultrasensitive, although to a lesser extent. This mild ultrasensitive response becomes Michaelian as phosphosites are mutated, indicating that some fraction of Cdc25C's ultrasensitivity is the result of multisite phosphorylation by Cdk1. However, a significant remaining fraction of the response cannot be explained by intrinsic ultrasensitivity, and appears to be due to extract-specific factors.
  • 2007 Springer
    Ohnesorge, Bernd M.
  • 2006
    Coakley, Fergus V.; Knollmann, Friedrich.
    Status: Not Checked OutLane Catalog Record
  • 2009 Springer
    Becker, C. R.; Glazer, Gary M.; Nikolaou, Konstantin; Reiser, Maximilian F.
    Also available: Print – 2009
  • 2012 Springer
    Zech, Christoph Johannes.
    Physical Background of Multi Detector Row Computed Tomography / Thomas Flohr -- Future Developments for MSCT / Patrik Rogalla -- Radiation Exposure and Risk Associated with CT Examinations / Gunnar Brix and Elke A. Nekolla -- Contrast Agent Application and Protocols / Markus S. Juchems -- Imaging Findings of Cirrhotic Liver / Jeong Min Lee, Dong Ho Lee and Jeong-Hee Yoon -- Imaging Findings in Non-Cirrhotic Liver / Daniele Marin and Giuseppe Brancatelli -- Liver and Biliary System: Postoperative Findings / Magaly Zappa, Annie Sibert and Valérie Vilgrain -- Inflammatory Processes in the Liver and Biliary Tract / Wesley C. Chan and Benjamin M. Yeh -- Neoplastic Processes in Biliary System / Tae Kyoung Kim, Korosh Khalili and Hyun-Jung Jang -- Assessment of the Hepatic Vessels with MDCT / Rocio Perez-Johnston, Dipti K. Lenhart, Daniella F. Pinho and Dushyant V. Sahani -- MSCT Imaging of Acute and Chronic Pancreatitis / Shelby Fishback, David H. Kim and Perry J. Pickhardt -- Solid Pancreatic Masses / Alec J. Megibow -- Cystic Pancreatic Masses / A. Oto -- Imaging CT of the Spleen / Giovanni Morana and Christian Cugini -- Imaging of Post Pancreatic Surgery / R. Graziani, S. Mautone, M. C. Ambrosetti, M. Barillari and R. Manfredi, et al. -- Renal Masses / Anno Graser and Ullrich G. Mueller-Lisse -- Adrenal Masses / Julie H. Song and William W. Mayo-Smith -- Inflammatory and Infectious Disease of the Kidney and Urinary Collecting System / Ullrich G. Mueller-Lisse, Ulrike L. Mueller-Lisse, Eva M. Coppenrath and Anno Graser -- MSCT of the Stomach / Sameer Ahmed, Karen M. Horton, Elliot K. Fishman and Pamela T. Johnson -- Small Bowel / Franco Iafrate, Marco Rengo, Paola Lucchesi, Maria Ciolina and Paolo Baldassari, et al. -- MSCT of the Abdomen: Colon, Rectum and CT Colonography / Emanuele Neri, Annalisa Mantarro, Rossella Scandiffio, Pietro Bemi and Lorenzo Faggioni, et al. -- Mesenteric and Retroperitoneal Diseases / Antonella Filippone, Roberta Cianci and Antonio Raffaele Cotroneo -- Imaging Findings in Acute Abdomen / Borut Marincek.
  • 2011 Springer
    Bourguignon, Jean-Pierre; Christen, Yves; Jégou, B.; Kerdelhué, Bernard; Toppari, Jorma.
    Neuroendocrine effects of developmental PCB exposure, with particular reference to hypothalamic gene expression -- The kisspeptin system as putative target for endocrine disruption of puberty and reproductive health -- Effects of prenatal exposure to endocrine disrupters on cerebral cortex development -- Endocrine disruption of the thyroid and its consequences in development -- Neural progenitors are direct targets of xenoestrogens in zebrafish -- Exposure to environmental chemicals as a risk factor for diabetes development -- Contribution of endocrine disrupting chemicals to the obesity epidemic: consequences of developmental exposure -- Fetal and adult exposure to bisphenol-A as a contributing factor in the etiology of the metabolic syndrome -- Bisphenol A in the gut: another break in the wall? -- Adverse trends of male reproductive health in two nordic countries indicate environmental problems -- Origin of testicular dysgenesis syndrome disorders in the masculinization programming window: relevance to final testis size (=sperm production) -- Index.
  • 2006
    Katz, Mitchell H.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Carstensen, Claus H.; Davier, Matthias von.
    Introduction : Extending the Rasch model / Matthias von Davier, Jürgen Rost, Claus H. Carstensen -- Measurement models as narrative structures / Robert Mislevy, Chun-Wei Huang -- Testing generalized Rasch models / Cees A.W. Glas -- The mixed-coefficients multinomial logit model : a generalized form of the Rasch model / Raymond J. Adams, Margaret L. Wu -- Loglinear multivariate and mixture Rasch models / Henk Kelderman -- Mixture-distribution and HYBRID Rasch models / Matthias von Davier, Kentaro Yamamoto -- Application of the Saltus model to stagelike data : some applications and current developments / Karen Draney, Mark Wilson -- Determination of diagnostic cut-points using stochastically ordered mixed Rasch models / Svend Kreiner -- A HYBRID model for test speededness / Keith A. Boughton, Kentaro Yamamoto -- Multidimensional three-mode Rasch models / Claus H. Carstensen, Jürgen Rost -- (Almost) equivalence between conditional and mixture maximum likelihood estimates for some models of the Rasch type / Anton K. Formann -- Rasch models for longitudinal data / Thorsten Meiser -- The interaction model / Shelby J. Haberman -- Multilevel Rasch models / Akihito Kamata, Yuk Fai Cheong -- Mixed Rasch models for measurement in cognitive psychology / Susan E. Embretson -- Detecting response styles and faking in personality and organizational assessments by mixed Rasch models / Michael Eid, Michael J. Zickar -- Application of multivariate Rasch models in international large-scale educational assessments / Raymond J. Adams, Margaret L. Wu, Claus H. Carstensen -- Studying development via item response models : a wide range of potential uses / Judith Glück, Christiane Spiel -- A comparison of the Rasch model and constrained item response theory models for pertinent psychological test data / Klaus D. Kubinger, Clemens Draxler -- Latent-response Rasch models for strategy shifts in problem-solving processes / Carl P.M. Rijkes, Henk Kelderman -- Validity and objectivity in health-related scales : analysis by graphical loglinear Rasch models / Svend Kreiner, Karl Bang Christensen -- Applications of generalized Rasch models in the sport, exercise, and the motor domains / Gershon Tenenbaum, Bernd Strauss, Dirk Büsch.
  • 2011 CRCnetBASE
    Berridge, Damon; Crouchley, Robert.
    Machine generated contents note: 2.1. Introduction -- 2.2. Continuous/interval scale data -- 2.3. Simple and multiple linear regression models -- 2.4. Checking assumptions in linear regression models -- 2.5. Likelihood: multiple linear regression -- 2.6. Comparing model likelihoods -- 2.7. Application of a multiple linear regression model -- 2.8. Exercises on linear models -- 3.1. Binary data -- 3.1.1. Introduction -- 3.1.2. Logistic regression -- 3.1.3. Logit and probit transformations -- 3.1.4. General logistic regression -- 3.1.5. Likelihood -- 3.1.6. Example with binary data -- 3.2. Ordinal data -- 3.2.1. Introduction -- 3.2.2. The ordered logit model -- 3.2.3. Dichotomization of ordered categories -- 3.2.4. Likelihood -- 3.2.5. Example with ordered data -- 3.3. Count data -- 3.3.1. Introduction -- 3.3.2. Poisson regression models -- 3.3.3. Likelihood -- 3.3.4. Example with count data -- 3.4. Exercises -- 4.1. Introduction -- 4.2. The linear model 4.3. The binary response model -- 4.4. The Poisson model -- 4.5. Likelihood -- 5.1. Introduction -- 5.2. Linear mixed model -- 5.3. The intraclass correlation coefficient -- 5.4. Parameter estimation by maximum likelihood -- 5.5. Regression with level-two effects -- 5.6. Two-level random intercept models -- 5.7. General two-level models including random intercepts -- 5.8. Likelihood -- 5.9. Residuals -- 5.10. Checking assumptions in mixed models -- 5.11. Comparing model likelihoods -- 5.12. Application of a two-level linear model -- 5.13. Two-level growth models -- 5.13.1. A two-level repeated measures model -- 5.13.2. A linear growth model -- 5.13.3. A quadratic growth model -- 5.14. Likelihood -- 5.15. Example using linear growth models -- 5.16. Exercises using mixed models for continuous/interval scale data -- 6.1. Introduction -- 6.2. The two-level logistic model -- 6.3. General two-level logistic models -- 6.4. Intraclass correlation coefficient -- 6.5. Likelihood -- 6.6. Example using binary data -- 6.7. Exercises using mixed models for binary data 7.1. Introduction -- 7.2. The two-level ordered logit model -- 7.3. Likelihood -- 7.4. Example using mixed models for ordered data -- 7.5. Exercises using mixed models for ordinal data -- 8.1. Introduction -- 8.2. The two-level Poisson model -- 8.3. Likelihood -- 8.4. Example using mixed models for count data -- 8.5. Exercises using mixed models for count data -- 9.1. Introduction -- 9.2. The mixed linear model -- 9.3. The mixed binary response model -- 9.4. The mixed Poisson model -- 9.5. Likelihood -- 10.1. Introduction -- 10.2. Three-level random intercept models -- 10.3. Three-level generalized linear models -- 10.4. Linear models -- 10.5. Binary response models -- 10.6. Likelihood -- 10.7. Example using three-level generalized linear models -- 10.8. Exercises using three-level generalized linear mixed models -- 11.1. Introduction -- 11.2. Multivariate two-level generalized linear model -- 11.3. Bivariate Poisson model: example -- 11.4. Bivariate ordered response model: example -- 11.5. Bivariate linear-probit model: example -- 11.6. Multivariate two-level generalized linear model likelihood 11.7. Exercises using multivariate generalized linear mixed models -- 12.1. Introduction -- 12.1.1. Left censoring -- 12.1.2. Right censoring -- 12.1.3. Time-varying explanatory variables -- 12.1.4. Competing risks -- 12.2. Duration data in discrete time -- 12.2.1. Single-level models for duration data -- 12.2.2. Two-level models for duration data -- 12.2.3. Three-level models for duration data -- 12.3. Renewal data -- 12.3.1. Introduction -- 12.3.2. Example: renewal models -- 12.4. Competing risk data -- 12.4.1. Introduction -- 12.4.2. Likelihood -- 12.4.3. Example: competing risk data -- 12.5. Exercises using renewal and competing risks models -- 13.1. Introduction -- 13.2. Mover-stayer model -- 13.3. Likelihood incorporating the mover-stayer model -- 13.4. Example 1: stayers within count data -- 13.5. Example 2: stayers within binary data -- 13.6. Exercises: stayers -- 14.1. Introduction to key issues: heterogeneity, state dependence and non-stationarity -- 14.2. Example -- 14.3. Random effects models -- 14.4. Initial conditions problem -- 14.5. Initial treatment 14.6. Example: depression data -- 14.7. Classical conditional analysis -- 14.8. Classical conditional model: example -- 14.9. Conditioning on initial response but allowing random effect uol to be dependent on z3 -- 14.10. Wooldridge conditional model: example -- 14.11. Modelling the initial conditions -- 14.12. Same random effect in the initial response and subsequent response models with a common scale parameter -- 14.13. Joint analysis with a common random effect: example -- 14.14. Same random effect in models of the initial response and subsequent responses but with different scale parameters -- 14.15. Joint analysis with a common random effect (different scale parameters): example -- 14.16. Different random effects in models of the initial response and subsequent responses -- 14.17. Different random effects: example -- 14.18. Embedding the Wooldridge approach in joint models for the initial response and subsequent responses -- 14.19. Joint model incorporating the Wooldridge approach: example -- 14.20. Other link functions -- 14.21. Exercises using models incorporating initial conditions/state dependence in binary data 15.1. Introduction -- 15.2. Fixed effects treatment of the two-level linear model -- 15.3. Dummy variable specification of the fixed effects model -- 15.4. Empirical comparison of two-level fixed effects and random effects estimators -- 15.5. Implicit fixed effects estimator -- 15.6. Random effects models -- 15.7. Comparing two-level fixed effects and random effects models -- 15.8. Fixed effects treatment of the three-level linear model -- 15.9. Exercises comparing fixed effects and random effects -- A.1. SabreR installation -- A.2. SabreR commands -- A.2.1. The arguments of the SabreR object -- A.2.2. The anatomy of a SabreR command file -- A.3. Quadrature -- A.3.1. Standard Gaussian quadrature -- A.3.2. Performance of Gaussian quadrature -- A.3.3. Adaptive quadrature -- A.4. Estimation -- A.4.1. Maximizing the log likelihood of random effects models -- A.5. Fixed effects linear models -- A.6. Endogenous and exogenous variables -- B.1. Getting started with R -- B.1.1. Preliminaries -- B.1.1.1. Working with R in interactive mode -- B.1.1.2. Basic functions -- B.1.1.3. Getting help B.1.1.4. Stopping R -- B.1.2. Creating and manipulating data -- B.1.2.1. Vectors and lists -- B.1.2.2. Vectors -- B.1.2.3. Vector operations -- B.1.2.4. Lists -- B.1.2.5. Data frames -- B.1.3. Session management -- B.1.3.1. Managing objects -- B.1.3.2. Attaching and detaching objects -- B.1.3.3. Serialization -- B.1.3.4. R scripts -- B.1.3.5. Batch processing -- B.1.4. R packages -- B.1.4.1. Loading a package into R -- B.1.4.2. Installing a package for use in R -- B.1.4.3. R and Statistics -- B.2. Data preparation for SabreR -- B.2.1. Creation of dummy variables -- B.2.2. Missing values -- B.2.3. Creating lagged response covariate data.
  • 2014 ClinicalKey
    Arulkumaran, Sabaratnam; Baskett, Thomas F.; Calder, A. A.; Munro Kerr, J. M.; Ramsden, Ian.
    A highly illustrated, practical book covering the obstetric and surgical procedures used in intrapartum care, including commonly used procedures such as assisted vaginal delivery (forceps and vacuum delivery) and more rare techniques such as major vessel ligation and embolization and internal podalic version. The authors take a step-by-step approach to each technique and includes 'tips' and 'pointers' that only an experienced obstetrician would be able to describe. The book is enlivened by the inclusion of short, relevant 'historical highlights'- readers should find these enlightening and entertaining, providing a link with the original Munro Kerr text. Focuses on the intrapartum aspects of obstetric practice - the focus of medico-legal and clinical audit attention. Highly illustrated to show techniques in detailOffers tips and advice to the trainee. Emphasis on practical matters - a step-by-step approachIncludes historical boxes to enliven and entertain.
  • Katz, Jonathan Glustrom.
    Civilization's martyr -- The Road to Marrakesh -- Europeans and Jews -- A Doctor in Marrakesh -- False starts and false reports -- March 19, 1907 -- In Morocco, no one dies without a reason -- Negotiations -- The Crisis of the month -- Remains of the day.
  • 2015 Springer
    Berger, Nathan A.
    This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
  • 2016 ClinicalKey
    Broaddus, V. Courtney; Mason, Robert J.; Murray, John F.; Nadel, Jay A.
    Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel's Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases.
  • 2016 Springer Protocols
    Jakubik, Jan; Myslivecek, Jaromir.
  • 2012 Springer
    Christopoulos, Arthur; Fryer, Allison D.; Nathanson, Neil M.
    Muscarinic receptor pharmacology and signaling -- Overview of muscarinic receptor subtypes -- Structure-function studies of muscarinic acetylcholine receptors -- Polymorphisms in human muscarinic receptor subtype genes -- Muscarinic receptor trafficking -- Physiological role of G-protein coupled receptor phosphorylation -- Novel muscarinic receptor mutant mouse models -- Muscarinic receptors in the CNS -- Muscarinic receptor pharmacology and circuitry for the modulation of cognition -- Muscarinic agonists and antagonists in schizophrenia -- Muscarinic pain pharmacology: realizing the promise of novel anagesics by overcoming old challenges -- Muscarinic modulation of striatal function and circuitry -- Muscarinic receptors in brain stem and mesopontine cholinergic arousal functions -- Muscarinic receptors in autonomic effector organs -- Muscarinic receptor agonists and antagonists: effects on ocular function -- Muscarinic receptor agonists and antagonists: effects on cardiovascular function -- Muscarinic receptor antagonists: effects on pulmonary function -- Muscarinic agonists and antagonists: effects on gastrointestinal function -- Muscarinic agonists and antagonists: effets on the urinary bladder -- Muscarinic receptors and mediation of hormonal effects of acetylcholine -- Muscarinic receptor agonists and antagonists: effects on inflammation and immunity -- Muscarinic receptor agonists and antagonists: effects on keratinocyte functions -- Muscarinic receptor agonists and antagonists: effects on cancer -- Activation of muscarinic receptors by non-neuronal acetylcholine.
  • 2010 Springer
    Rassier, Dilson E.
    Also available: Print – 2010
  • 2013 ClinicalKey
    Dubowitz, Victor; Lane, Russell J. M.; Oldfors, Anders; Sewry, Caroline A.
    The Procedure of Muscle Biopsy -- Histological and Histochemical Stains and Reactions -- Normal Muscle -- Histological and Histochemical changes -- Ultrastructural Changes -- Immunohistochemistry and Immunoblotting -- How to Read A Biopsy -- Classification of Neuromuscular Disorders -- Neurogenic Disorders -- Muscular Dystrophies and Allied Disorders I: Duchenne and Becker Muscular Dystrophy -- Muscular Dystrophies and Allied Disorders II: Limb-Girdle Muscular Dystrophies -- Muscular Dystrophies and Allied Disorders III: Congenital Muscular Dystrophies and Associated Disorders -- Muscular Dystrophies and Allied Disorders IV: Emery-Dreifuss Muscular Dystrophy and Similar Syndromes -- Muscular Dystrophies and Allied Disorders V: Facioscapulohumeral, Myotonic and Oculopharyngeal Muscular Dystrophies -- Myopathies with Vacuoles -- Metabolic Myopathies I: Glycogenoses and Lysosomal Myopathies -- Metabolic Myopathies II: Lipid-Related Disorders and Mitochondrial Myopathies -- Myopathies Associated with Systemic Disorders and Ageing -- Ion Channel Disorders -- Myasthenic Syndromes -- Inflammatory Myopathies -- Toxic and Drug-Induced Myopathies -- Appendix 2: Useful Websites.
  • 2012
    Hamner, Samuel Richard; Delp, Scott; Khatib, Oussama; Roth, Bernard.
    Human running is a bouncing gait during which the body mass center slows and lowers during the first half of the stance phase; muscle forces then accelerate the mass center forward and upward in the second half of stance. Muscle-driven simulations of running allow us to determine how muscle forces give rise to the accelerations of the body mass center. Before this dissertation, it remained unclear how muscle forces modulate accelerations of the mass center at various running speeds as three-dimensional, muscle-driven simulations of running had yet been created or analyzed. Thus the goal of this dissertation was to better understand the functional role of muscles by generating the first three-dimensional, muscle-driven simulation of the running gait cycle and quantifying how muscles contribute to vertical and fore-aft accelerations of the body mass center over a range of running speeds. Initially, I created a three-dimensional, muscle-driven simulation of a single subject running at a single speed and quantitatively described how individual muscles accelerated the subject's body mass center. The simulation was generated with a musculoskeletal model driven by 92 musculotendon actuators of the lower extremities and torso. The model also included torque-driven arms, which allowed me to investigate the contributions of arm motion to running dynamics. This single simulation revealed that during the first half of the stance phase, quadriceps was the largest contributor to backward and upward accelerations of the mass center. During the second half of stance, the soleus and gastrocnemius muscles were the greatest contributors to forward and upward accelerations of the mass center. To determine how individual muscle forces in these simulations acted to generate the ground reaction force, and the resulting accelerations of the body mass center, it is necessary to model ground contact. The accelerations computed in such simulation analyses are sensitive to the model used to represent contact between the foot and ground. To have confidence in our ability to interpret muscle function, a ground contact model should be able to reproduce experimentally measured ground reaction forces and moments. I show that a rolling constraint accurately reproduces the measured ground reaction forces and moments in an induced acceleration analysis of muscle-driven simulations for walking, running, and crouch gait. I also evaluated other contact models used in previous studies (e.g., point and weld constraints) to illustrate that these models can produce inaccurate reaction moments and lead to contradictory interpretations of muscle function, including the contribution of major muscles, like the vasti and soleus, to fore-aft and upward mass center accelerations. To determine how muscles modulate ground reaction forces and mass center accelerations over a range of running speeds, I created muscle-driven simulations of ten subjects running at four speeds: 2 m/s, 3 m/s, 4 m/s, and 5 m/s. An induced acceleration analysis was used to determine the contribution of each muscle to body mass center accelerations. Analysis of the simulations revealed that soleus provides the greatest upward mass center acceleration at all running speeds, with a peak upward acceleration of 19.8 m/s/s (i.e., the equivalent of approximately 2.0 body weights of ground reaction force) at 5.0 m/s. Soleus also provided the greatest contribution to forward mass center acceleration, with contributions increasing from 2.5 m/s/s to 4.0 m/s/s as running speed increased from at 2.0 m/s to 5.0 m/s. Quadriceps produced the largest backward mass center acceleration; at 5.0 m/s peak contribution from quadriceps was 80% of total peak backward acceleration. At higher running speeds, greater velocity of the legs produced larger vertical angular momentum about the mass center, while vertical angular momentum from arm swing simultaneously increased to counterbalance that of the legs. The ability to reproduce the results of a study is an essential principle of the scientific method. However, reproducing results of simulation studies remains challenging because the software, models, and data used to create and analyze the simulations are generally not freely available. Thus, to promote the utilization and acceptance of simulations in movement science, I have provided open-access to the models, data, and subject-specific simulations developed for this dissertation at https://simtk.org/home/RunningSim and https://simtk.org/home/nmbl_running. The data and simulations can be visualized and results can be reproduced in OpenSim (http://opensim.stanford.edu), a freely-available biomechanics simulation package.
  • 2006 Springer
    Sink, Helen.
    An introduction to muscle development in drosophila / Helen Sink -- The muscle pattern of drosophila / Volker Hartenstein -- Mesoderm formation in the drosophila embryo / Noriko Wakabayashi-Ito and Y. Tony Ip -- Development of the cardiac musculature / Rolf Bodmer -- Development of the somatic gonad and fat bodies / Mark Van Doren -- Development of the larval visceral musculature / Hsiu-Hsiang Lee, Stephane Zaffran and Manfred Frasch -- Development of the larval somatic musculature / Ana Carmena and Mary Baylies -- Muscle morphogenesis: the process of embryonic myoblast fusion / Susan M. Abmayr and Kiranmai S. Kocherlakota -- Muscle attachment sites-where migrating muscles meet their match / Talila Volk -- Neuromuscular development: connectivity and plasticity / Louise Nicholson and Haig Keshishian -- Metamorphosis and the formation of the adult musculature / Devkanya Dutta and K. VijayRaghavan -- Molecular basis of muscle structure / Jim O. Vigoreaux -- Whole genome approaches to studying drosophila muscle development / Eileen E.M. Furlong -- Comparison of muscle development in drosophila and vertebrates / Michael V. Taylor.
  • 2012 ScienceDirect
    2012 ClinicalKey
    Hill, Joseph A.; Olson, Eric N.
  • 2010 Springer
    Duan, Dongsheng.
  • 2002 CRCnetBASE
    Wallberg-Henriksson, Harriet; Zierath, Juleen R.
    Perspectives / Eleazar Shafrir -- I. Insulin Signaling -- 1. Overview: Tyrosine Kinase Signaling in Insulin Action / Martin G. Myers, Jr. -- 2. Defects in Early Insulin Signaling in Skeletal Muscle / M. Dodson Michael and C. Ronald Kahn -- 3. Defects in Intermediate Insulin Signaling in Skeletal Muscle: Phosphatidylinositol (PI) 3-kinase and Glucose Transport / Francesco Giorgino -- II. Glucose Transport -- 4. Glucose Transport in Muscle / John O. Holloszy and Lorraine A. Nolte -- 5. The GLUT4 Compartments of Skeletal Muscle / Toolsie Ramlal, Peter Tong, Tony Lam, Romel Somwar, Maureen Charron and Amira Klip -- III. Substrate Utilization -- 6. Adverse Metabolic Consequences of Hyperglycemia ("Glucose Toxicity"): Implications for the Pathogenesis of Diabetes Mellitus / Donald A. McClain -- 7. Cellular Mediators of Glucose-Induced Autoregulation of Hexose Transport / Evgenia Alpert, Hanan Totary and Shlomo Sasson -- 8. Physiological Adaptations in Glucose Utilization of Skeletal Muscle / Julian M.R. Mathoo and Mladen Vranic -- 9. Fatty Acids and Muscle Insulin Resistance / Edward W. Kraegen, Gregory J. Cooney, Jiming Ye, Alison L. Thompson and Stuart M. Furler -- 10. Role of AMP Kinase and Malonyl CoA in Exercise-stimulated Skeletal Muscle Metabolism and Insulin Action / David J. Dean and Neil B. Ruderman -- IV. Transgenic and Genetic Models -- 11. The Use of Mouse Transgenic and Homologous Recombination.
  • 2010 Springer
    Gerwin, Robert; Mense, Siegfried.
    Part 1. Myofascial pain syndrome -- Myofascial Pain Syndrome / Robert D. Gerwin -- Morphology of Myofascial Trigger Points: What Does a Trigger Point Look Like? / Siegfried Mense -- Introduction / Siegfried Mense and Robert D. Gerwin -- Part 2. Fibromyalgia syndrome -- Fibromyalgia Syndrome: Clinical Aspects and Management / Emma Guymer and Geoffrey O. Littlejohn -- Gender, Genetics, and Other Risk Factors Increasing Vulnerability to Fibromyalgia / Geoffrey O. Littlejohn -- Part 3. Other muscle pain syndromes -- Low Back Pain of Muscular Origin / Robert D. Gerwin -- Masticatory Muscle Pain / Sandro Palla and Mauro Farella -- Inflammatory Myopathies / Ingrid E. Lundberg and Li Alemo Munters -- Whiplash Injury, Muscle Pain and Motor Dysfunction / Jan Dommerholt -- Brain Imaging of Muscle Pain / Sandra Kamping and Herta Flor.
  • 2010 Springer
    Gerwin, Robert; Mense, Siegfried.
    Introduction / Siegfried Mense and Robert D. Gerwin -- Functional anatomy of muscle : muscle, nociceptors, and afferent fibers / Siegfried Mense -- Peripheral mechanisms of muscle pain : response behavior of muscle nociceptors and factors eliciting local muscle pain / Siegfried Mense -- Central nervous mechanisms of muscle pain : ascending pathways, central sensitization, and pain-modulating systems / Siegfried Mense -- Referral of musculoskeletal pain / Thomas Graven-Nielsen and Siegfried Mense -- Increased muscle tone as a cause of muscle pain / Siegfried Mense and Alfonse T. Masi -- Reorganized motor control due to muscle pain / Thomas Graven-Nielsen and Lars Arendt-Nielsen.
  • 2013 ScienceDirect
    Garten, Hans.
    Especially prepared for the international audience, the English language edition of this highly successful handbook describes Professional Applied Kinesiology muscle testing procedures. A departure from the classic understanding of muscle testing for weakness and rehabilitation, these procedures can be used for detecting more subtle, functional abnormalities. Included within the chapters are stretch tests and post-isometric relaxation procedures for the hypertonic, shortened muscle. Muscle anatomy and physiology are briefly recapped in order to enhance reader comprehension. The Muscle Testing Handbook describes testing procedures for almost 100 individual muscles in a unique, quick reference, template approach. In close collaboration with Dr. Garten, the German edition has been adapted for the English-language audience by Dr. Shafer, an American chiropractic colleague. This book is ideal for use by manual therapists, physiotherapists, osteopaths, chiropractors, sports scientists and neurology department staff worldwide. Clearly describes modern muscle test procedures The individual aspects of each muscle are easily compared by the use of well-illustrated templated descriptions A double-page spread design allows the reader a rapid, at-a-glance access to essential information Muscle anatomy and function are succinctly recapped in order to facilitate a complete understanding of the relevance and applicability of the individual test Classic Applied Kinesiology muscle tests for detecting functional abnormalities are well described along with stretch testing and post-isometric relaxation procedures for hypertonic, shortened muscles The importance of postural analysis for the assessment of specific muscle dysfunction is discussed and plainly described Illustrates painful spondylogenic reflex points (areas) for each muscle The role of distal acupuncture points and tendinomuscular meridians in maintaining normal muscle and muscle chain function are noted in accompanying diagrams The most commonly found trigger points, their referred pain patterns and relationship to nearby acupuncture points are clearly illustrated for each muscle Perfect for use in orthopaedics, neurology, general medicine, physiotherapy, chiropractic and osteopathy.
  • 2010 CRCnetBASE
    Diogo, Rui; Abdala, Virginia.
    Chapter 1. Introduction and Aims -- Chapter 2. Methodology and Material -- Chapter 3. Muscles of Non-Osteichthyan Vertebrates -- Chapter 4. Head and Neck Muscles of Actinopterygians and Basal Sarcopterygians -- Chapter 5. From Sarcopterygian Fish to Modern Humans -- Chapter 6. Head and Neck Muscles of Amphibians -- Chapter 7. Head and Neck Muscles of Reptiles -- Chapter 8. Pectoral and Pectoral Fin Muscles of Actinopterygian and Sarcopterygian Fishes -- Chapter 9. From Sarcopterygian Fish to Modern Humans -- Chapter 10. Pectoral and Forelimb Muscles of Limbed Amphibians and Reptiles -- Chapter 11. General Comments.
  • 2011 ScienceDirect
    Amato, Anthony A.; Griggs, Robert C.
    Overview of the muscular dystrophies / A.A. Amato and R.C. Griggs -- Dystrophinopathies / L.A. Morrison -- Sarcoglycanopathies / J. Kirschner and H. Lochmüller -- Congenital muscular dystrophies / S.E. Sparks and D.M. Escolar -- The collagen VI-related myopathies : Ullrich congenital muscular dystrophy and Bethlem myopathy / C.G. Bönnemann -- Limb-girdle muscular dystrophy 2A / E. Gallardo, A.Saenz and I.Iilla -- Dysferlinopathies / A.A. Amato and R.H. Brown Jr -- Other limb-girdle muascular dystrophies / A.A. Amato -- Limb-girdle muscular dystrophy 2H and the role of TRIM32 / P.B. Shieh, E. Kudryashova and M.J. Spencer -- Caveolinopathies : translational implications of caveolin-3 in skeletal and cardiac muscle disorders / E. Gazzerro, A. Bonetto, and C. Minetti -- Myofibrillar myopathies / D. Selcen and A.G. Engel -- Emery-Dreifuss muscular dystrophy / M. Puckelwartz and E.M. McNally -- Facioscapulohumeral dystrophy and scapuloperoneal syndromes / R.W. Orrell -- Oculopharyngeal muscular dystrophy / B. Brais -- Myotonic dystrophy types 1 and 2 / T. Ashizawa and P.S. Sarkar -- Distal muscular dystrophies / B. Udd.
  • Springer Protocols
    Anderson, Louise V. B.; Bushby, Katherine M. D.
    Application of Molecular Methodologies in Muscular Dystrophies / Katharine M. Bushby, Louise V. Anderson -- Clinical Examination as a Tool for Diagnosis: Historical Perspective / David Gardner-Medwin -- Histopathological Diagnosis of Muscular Dystrophies / Margaret A. Johnson -- Serum Creatine Kinase in Progressive Muscular Dystrophies / Mayana Zatz, Mariz Vainzof, Maria Rita Passos-Bueno -- Deletion and Duplication Analysis in Males Affected with Duchenne or Becker Muscular Dystrophy / Ann Curtis, Daisy Haggerty -- Point Mutation Detection in the Dystrophin Gene / Johan T. Dunnen -- DNA-Based Techniques for Detection of Carriers of Duchenne and Becker Muscular Dystrophy / Egbert Bakker -- Fluorescence In Situ Hybridization Analysis for Carrier Detection in Duchenne/Becker Muscular Dystrophy / Jonathan K. Dore, Helen M. Kingston -- DNA- Based Prenatal Diagnosis for Duchenne and Becker Muscular Dystrophy / Ann Curtis, Daisy Haggerty -- Molecular Diagnosis and Genetic Counseling of the Manifesting Carrier of Duchenne Muscular Dystrophy / Eric P. Hoffman, James Giron -- Mutation Analysis of X-Linked Emery-Dreifuss Muscular Dystrophy Gene / Daniela Toniolo.
  • 2015 Springer
    Huml, Raymond A.
    Introduction to muscular dystrophy / Raymond A. Huml -- Muscular dystrophy : historical background and types / Raymond A. Huml -- FSHD : the most common type of muscular dystrophy? / Raymond A. Huml and Daniel P. Perez -- Duchenne and Becker muscular dystrophies : underlying genetic and molecular mechanisms / Jean K. Mah -- An overview of the other muscular dystrophies : underlying genetic and molecular mechanisms / Jean K. Mah -- Transition from childhood to adult in patients with muscular dystrophy / Elba Yesi Gerena Maldonado and Kathryn R. Wagner -- Overview of current treatments for muscular dystrophy / Zheng (Jane) Fan -- Physical therapy and orthotic devices / Laura E. Case -- Orthopedic management of the child with muscular dystrophy / Robert K. Lark and Elizabeth W. Hubbard -- Global regulatory landscape / Raymond A. Huml -- Key challenges to the approval of products to treat patients with muscular dystrophy / Raymond A. Huml -- Pharmaceutical products and non-pharmaceutical interventions as potential treatments for patients with muscular dystrophy / Raymond A. Huml -- US patient advocacy groups / Meredith L. Huml -- Global and national patient registries / Raymond A. Huml -- Summary / Raymond A. Huml.
  • 2016 Springer
    Dixon, J. Bryan.
    Taking a multidisciplinary approach to a common and often frustrating problem for athletes and those with an active lifestyle, this book is the first of its kind, addressing muscular injuries to the posterior leg using an in-depth and expansive style that is uniquely dedicated to ensuring all content is explicitly linked to the practical care of patients with calf pain. It is divided thematically into three sections. The first section covers underlying principles involved in these issues, including anatomy, physiology, pathophysiology of injury and neurophysiology of musculoskeletal pain. Clinical assessment techniques and imaging are covered in the second section. The third section on treatment is the most expansive, discussing acute, sub-acute and chronic posterior leg muscle injuries, as well as surgical management, rehabilitation techniques, complementary medicine and special populations. Overall, the book is designed to use muscular injuries of the posterior leg to as a means to understand the assessment and treatment of muscular injuries more broadly. Taken together, it is the consummate source for orthopedists, doctors in sports medicine, podiatrists, rehabilitation professionals and primary care physicians who treat muscular injuries in the posterior leg, though readers will gain a conceptual and practical framework for the assessment and treatment of muscular injuries in general.
  • 2009 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • 2013 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
    Written by internationally renowned experts, this updated volume is a collection of chapters dealing with imaging diagnosis and interventional therapies in musculoskeletal diseases. The different topics are disease-oriented and encompass all the relevant imaging modalities including X-ray technology, nuclear medicine, ultrasound and magnetic resonance, as well as image-guided interventional techniques. This publication, includingexcellent radiologicimages andcolor illustrations,will appeal not onlytoradiologists, rheumatologists, orthopaedics surgeons, but also to clinicians in other specialties wishing to update their knowledge in this field.
  • 2005 Springer
    Hodler, Jürg; Schulthess, Gustav Konrad von; Zollikofer, Ch. L.
  • NAP
  • 2013 ClinicalKey
    Browner, Bruce D.; Fuller, Robert.
    General Principles of Initial Care -- Radiographic Imaging -- Infections Involving the Musculoskeletal System -- Analgesia, Conscious Sedation, Regional Blocks, and Anesthesia -- Analgesia, Conscious Sedation, Regional Blocks, and Anesthesia -- Perioperative Assessment -- Pregnancy -- Spine -- Shoulder -- Elbow and Distal Humerus -- Wrist and Forearm -- Hand and Digits -- Hip and Thigh -- Distal Femur, Knee, and Patella -- Ankle -- Foot -- Pelvis -- Introduction to Pediatric Trauma -- Pediatric Pathologic Fractures --Pediatric Shoulder and Humeral Shaft -- Pediatric Elbow -- Pediatric Forearm and Distal Radius and Ulna Fractures -- Pediatric Hand Injuries -- Pediatric Cervical Spine Fractures -- Pediatric Thoracolumbar Spine Fractures -- Pediatric Thoracolumbar Spine Fractures -- Pediatric Fractures and Dislocations of the Hip -- Pediatric Femur -- Fractures of the Pediatric Knee -- Pediatric Tibia and Fibular Shaft and Ankle Fractures -- Pediatric Foot -- Appendix Administrative and Regulatory Issues Relating to Emergency Department Management of Musculoskeletal Emergencies.
  • 2006
    Fam, Adel G.; Kreder, Hans J.; Lawry, George V.
    Status: Not Checked OutLane Catalog Record
  • 2009
    Gross, Jeffrey M.; Fetto, Joseph; Rosen, Elaine.
    Status: Not Checked OutLane Catalog Record
    Basic concepts of physical examination -- Overview of the spine and pelvis -- The cervical spine and thoracic spine -- The temporomandibular joint -- The lumbosacral spine -- Overview of the upper extremity -- The shoulder -- The elbow -- The wrist and hand -- The hip -- The knee -- The ankle and foot -- Gait.
  • 2001 CRCnetBASE
    Burr, David B.; Milgrom, Chuck.
    ch. 1. Incidence and prevalence of stress fractures in military and athletic populations / Richard A. Shaffer -- ch. 2. Risk factors for developing stress fractures / Kim Bennell and Susan Grimston -- ch. 3. Factors associated with the development of stress fractures in women / Kim Bennell and Susan Grimston -- ch. 4. The role of age in the development of stress and fatigue fractures / Antero Hulkko and Sakari Orava -- ch. 5. The prediction of stress fractures / Thomas J. Beck -- ch. 6. Bone fatigue and stress fractures / Scott A. Yerby and Dennis R. Carter -- ch. 7. The Genetic basis for stress fractures / Eitan Friedman, Iris Vered, and Jushua Shemer -- ch. 8. The role of strain and strain rates in stress fractures / Charles Milgrom -- ch. 9. The Role of muscular force and fatigue in stress fractures / Seth W. Donahue -- ch. 10. The histological appearance of stress fractures / Satoshi Mori, Jiliang Li, and Yoji Kawaguchi -- ch. 11. Bone fatigue and remodeling in the development of stress fractures / Mitchell B. Schaffler -- ch. 12. The role of bone remodeling in preventing or promoting stress fractures / R. Bruce Martin -- ch. 13. Bucked shins in horses / David Nunamaker -- ch. 14. Rabbits as an animal model for stress fractures / David B. Burr -- ch. 15. Prevention of stress fractures by modifying shoe wear / Aharon S. Finestone -- ch. 16. Exercise programs that prevent or delay the onset of stress fracture / Charles Milgrom and Richard Shaffer -- ch. 17. Pharmaceutical treatments that may prevent or delay the onset of stress fractures / David B. Burr -- ch. 18. Physical diagnosis of stress fractures / Ingrid Ekenman -- ch. 19. The role of various imaging modalities in diagnosing stress fractures / Roland Chisin -- ch. 20. Early diagnosis and clinical treatment of stress fractures / Charles Milgrom and Eitan Friedman -- ch. 21. Problematic stress fractures / Kenneth A. Egol and Victor H. Frankel.
  • 2015 Springer
    Fitzgerald, Colleen M.; Segal, Neil A.
    Providing clinicians with a comprehensive, evidence-based summary of musculoskeletal health in pregnancy and postpartum, this is the first book of its kind to describe the physiologic changes, prevalence, etiology, diagnostic strategies, and effective treatments for the most common musculoskeletal clinical conditions encountered during this phase of life. Lumbopelvic pain, upper and lower extremity diagnoses, labor and delivery considerations, including the impact on the pelvic floor, and medical therapeutics will be discussed. Additionally, the importance and influence of exercise in pregnancy, the long-term implications of musculoskeletal health in pregnancy and current and future directions for research will be addressed. The childbearing period is a time of remarkable reproductive and musculoskeletal change, predisposing women to potential injury, pain, and resultant disability. Musculoskeletal Health in Pregnancy and Postpartum offers musculoskeletal medicine specialists, obstetricians and any clinicians involved in the care of pregnant or postpartum women the tools necessary to prepare for, treat and prevent these concurrent injuries during an already challenging time.
  • 2014 Springer
    Matzkin, Elizabeth; Mody, Elinor A.
    Musculoskeletal Health in Women aims to provide fitness advice tailored to women. As women are more prone to specific injuries than men are, due to differences in hip and knee anatomy as well as hormonal differences, this book will provides a fully-illustrated and comprehensive overview of all aspects including energy availability (which is affected by eating disorders), osteoporosis, and menstrual function. Its multidisciplinary approach ensures that expertise is provided from disciplines such as psychiatry, physiatry, endocrinology, nutrition, rheumatology, orthopedics, physical therapy and radiology. Written by authors who have extensive experience working with women athletes, Musculoskeletal Health in Women addresses a full spectrum of issues related to the musculoskeletal health of women. It is of primary interest to women athletes and women embarking on a fitness regimen. Health professionals working in this area would also invariably benefit from the advice and guidance provided within these pages.
  • 2008 Thieme Book
    Reiser, Maximilian F.; Baur-Melnyk, Andrea; Glaser, Christian.
    1. Tumors -- Osteoma -- Osteoid osteoma -- Enchondroma -- Osteochondoroma (cartilaginous exostosis) --Nonossifying fibroma -- Fibrous dysplasia (Jaffe-Lichtenstein Disease) -- Juvenile bone cyst -- Aneurysmal bone cyst -- Giant cell tumor (Osteoclastoma) -- Synovial chondromatosis (Reichel Syndrome) -- Bone hemangioma -- Paget Diesase (Ostetis Deformans) --Metastases -- Osteosarcoma -- Ewind sarcoma -- Multiple myeloma (plasmacytoma) -- Lymphoma of bone -- Neoplastic vertebral compression fracture -- Soft-tissue hemangioma -- Soft-tissue sarcoma -- Lipoma -- Pigmented villonodular synovitis -- Myositis ossificans -- 2. Inflammatory diseases -- Osteomyelitis -- Brodie abscess -- Rheumatoid arthritis -- Psoriatic arthritis/psoriatic arthropathy -- Septic arthritis -- Gout (gouty arthritis) -- Ankylosing spondylitis -- Spondylitis and spondylodiskitis -- Complex regional pain syndrome -- 3. Degenerative disease -- Osteoarthritis -- Osteochondrosis -- Intervertebral disk herniation -- Spinal canal stenosis -- Spondylolysis/spondylolisthesis -- Implant loosening -- Diffuse idiopathic skeletal hyperostosis -- Neuropathic osteoarthropathy (charcot joint) -- 4. Metabolic disorders -- Osteoporosis -- Rickets -- Osteomalacia -- Hyperparathyroidism -- 5. Developmental disorders -- Madelund deformity -- Hip dysplasia -- Tibia vara (Blount Disease) -- Slipped capital femoral epiphysis -- Club foot (talipes equinovarus) -- Scoliosis -- Osteogenesis imperfecta -- Osteopetrosis (Marble Bone Disease) -- Scheuermann Disease -- 6. Osteonecrosis -- Perthes Disease -- Osteonecrosis of the knee -- Lunatomalacia (Kienbock Disease) -- Femoral head necrosis -- Osteochondritis dissecans -- Bone infarct -- 7. Intra-articular lesions -- Meniscal lesions -- Cruciate ligament tears -- Cartilage lesions -- Labral lesions -- Rotator cuff lesions -- 8. Ligament and tendon injuries -- Lateral ankle ligament rupture -- Achilles tendon rupture -- Avulsion fracture -- Shoulder impingement -- 9. Fractures and dislocations -- Clavicle fracture -- Acromioclavicular separation -- Proiximal humerus fractures -- Shoulder dislocation -- Radial head fracture -- Pediatric condylar fractures -- Distal radius fracture -- scaphoid fracture -- Triquetrum fracture -- Skier's thumb (gamekeeper's thumb) -- Dens fracture -- Femoral neck fracture -- pertrochanteric femoral fracture -- Patella fracture -- Tibial plateau fracture -- Ankle joint fractures -- Calcaneus fracture -- Fractures of the base of the fifth metatarsal -- Occult fracture -- Stress fracture - Pseudarthrosis.
  • 2006
    Chew, Felix S.; Lalaji, Anand P.; Roberts, Catherine C.
    Status: Not Checked OutLane Catalog Record
  • 2007
    Manaster, B. J.; Disler, David G.; May, David A.
    Status: Not Checked OutLane Catalog Record
  • 2008 ClinicalKey
    Yu, Joseph.
    This volume uses 200 case studies to challenge your knowledge of a full range of topics in musculoskeletal imaging. Whether you are preparing for the radiology board exams, recertifying, or looking to hone your diagnostic abilities, this book will help you read and interpret all imaging modalities used for the musculoskeletal system.
  • Yu, Joseph S.
    Status: Not Checked OutLane Catalog Record
  • 2007 Ovid
    Berquist, Thomas H.
  • 2015 ClinicalKey
    Beltran, Javier; Bloem, Hans L.; Morrison, William B.; Pope, Thomas Lee; Wilson, David J.
  • 2016 Springer
    Cameron, Kenneth L.; Owens, Brett D.
    Part I. The spectrum of musculoskeletal injuries in the military -- The burden of musculoskeletal injuries in the military / Brett D. Owens and Kenneth L. Cameron -- Traumatic combat injuries / Andrew J. Schoenfeld and Philip J. Belmont -- The burden of deployment-related non-battle injuries (NBIs) and their impact on the musculoskeletal system / Kenneth L. Cameron -- Sports and exercise-related injuries in the military / Michael Garrison, Scott Dembowski, and Nathan Shepard -- Musculoskeletal injuries during military initial entry training / Scott D. Carow and Jennifer L. Gaddy -- Disability associated with musculoskeletal injuries / Chad A. Krueger and James R. Ficke -- Part II. The epidemiology of musculoskeletal injuries by anatomic region -- Shoulder injuries / Christopher J. Tucker and Brett D. Owens -- Elbow, wrist, and hand injuries / Danielle L. Scher, Emily H. Shin, Jennifer M. Wolf, and Leon J. Nesti -- Hip injuries / Joseph T. Lanzi and Steven J. Svoboda -- Knee injuries / Jeremy McCallum and John M. Tokish -- Lower leg, ankle, and foot injuries / Brian R. Waterman, John Dunn, and Justin D. Orr -- Thoracic and lumbar spine injuries / Jeffrey B. Knox and Joseph Orchowski -- Cervical spine and neck injuries / Scott C. Wagner and Ronald A. Lehman -- Part III. Public health strategies for injury prevention and treatment in the military -- Application of the public health model for musculoskeletal injury prevention within the military / Kenneth L. Cameron -- Successful injury prevention interventions / Sarah J. de la Motte and Robert Oh -- Overcoming barriers to injury prevention in the military / Deydre S. Teyhen, Stephen L. Goffar, Timothy L. Pendergrass, Scott W. Shaffer, and Nikki Butler.
  • 2006 Springer
    Paterson, John K.
    What Is Musculoskeletal Medicine? -- The Scientific Bases of Musculoskeletal Medicine -- The Patient's View of Musculoskeletal Medicine -- The Doctor's View of Musculoskeletal Medicine -- The Economics of Musculoskeletal Medicine -- Teaching Musculoskeletal Medicine -- Headache and Migraine -- Neck Pain -- Shoulder and Arm Pain -- Chest Pain -- Lower Trunk Pain -- Pelvic Pain -- Leg Pain -- Will Musculoskeletal Medicine Work? -- The Future of Musculoskeletal Medicine.
  • 2009 ClinicalKey
    Anderson, Mark W.; Dussault, Robert; Helms, Clyde A.; Kaplan, Phoebe; Major, Nancy M.
    Basic principles of musculoskeletal MRI -- Marrow -- Tendons and muscles -- Peripheral nerves -- Musculoskeletal infections -- Arthritis and cartilage -- Tumors -- Osseous trauma -- Temporomandibular joint -- Shoulder -- Elbow -- Wrist and hand -- Spine -- Hips and pelvis -- Knee -- Foot and ankle.
    Also available: Print – 2009
  • 2010 Thieme Book
    Garcia, Glenn M.
    RadCases contains cases selected to simulate everything that you'll see on your rounds, rotations, and exams. RadCases also helps you identify the correct differential diagnosis for each case - including the most critical. RadCases covers: cardiac imaging, interventional radiology, musculoskeletal imaging, neuro imaging, chest imaging, pediatric imaging, gastrointestinal imaging, breast imaging, nuclear medicine, ultrasound imaging, head and neck imaging, and genitourinary imaging. Each RadCases title features 100 carefully selected, must-know cases documented with clear, high-quality radiographs. The organization provides maximum ease of use for self-assessment. Each case begins with the clinical presentation on the right-hand page; simply turn the page for imaging findings, differential diagnoses, the definitive diagnosis, essential facts, and more. Each RadCases title includes a scratch-off code that allows 12 months of access to a searchable online database of all 100 cases from the book plus an additional 150 cases in that book's specialty - 250 cases in total! Learn your cases, diagnose with confidence and pass your exams.
  • Garcia, Glenn M.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Martino, Fabio.
  • 2008 Springer
    Pietrzak, William S.
    Also available: Print – 2008
  • 2015 Springer
    Miedany, Yasser El.
    1. Fundamentals of musculoskeletal ultrasound -- 2. Pitfalls in musculoskeletal ultrasound -- 3. Rheumatod arthritis -- 4. Ankylosing spondylitis -- 5. Psoriatic arthritis -- 6. Osteoarthritis -- 7. Crystal-induced arthritis -- 8. Skin, nail and hair in rheumatology -- 9. Pediatric musculoskeletal disorders -- 10. Carpal tunnel syndrome -- 11. Soft tissue rheumatism -- 12. Inflammatory allied conditions -- 13. Sports medicine -- 14. Ultrasound-guided interventional maneuvers -- Index.
  • 2010 Thieme Book
    Dogra, Vikram; Gaitini, Diana.
    With an emphasis on the accuracy and dynamic nature of no-radiation ultrasound, leading clinicians from around the world provide practical guidance on how to combine different multiplanar imaging modalities in the analysis and diagnosis of common musculoskeletal disorders. Organized by body region, each of the 13 chapters follows a consistent, easy-to-reference format. The authors guide the reader through clinical indications, technical guidelines, and normal anatomy followed by information on degenerative diseases, inflammatory conditions, traumatic injuries, tumors, and various other musculoskeletal problems. Clear, high-resolution ultrasound images appear side by side with MRI, and in some cases CT, images to teach and train readers how to perform musculoskeletal ultrasound in clinical practice while simultaneously sharpening their diagnostic skills.
  • 2015 ScienceDirect
    Altenmüller, Eckart; Boller, François; Finger, Stanley.
  • 2015 ScienceDirect
    Altenmüller, Eckart; Boller, François; Finger, Stanley.
    Music, Neurology, and Neuroscience: Historical Connections and Perspectives provides a broad and comprehensive discussion of history and new discoveries regarding music and the brain, presenting a multidisciplinary overview on music processing, its effects on brain plasticity, and the healing power of music in neurological and psychiatric disorders. In this context, the disorders that plagued famous musicians and how they affected both performance and composition are critically discussed, as is music as medicine and its potential health hazard. Additional topics, including the way music fits into early conceptions of localization of function in the brain, its cultural roots in evolution, and its important roles in societies and educational systems are also explored.Examines music and the brain both historically and in the light of the latest research findings The largest and most comprehensive volume on "music and neurology" ever writtenWritten by a unique group of real world experts representing a variety of fields, ranging from history of science and medicine, to neurology and musicology Includes a discussion of the way music has cultural roots in evolution and its important role in societies
  • 2009 Springer
    Brandes, Vera; Haas, Roland.
    Introduction : music that works / Roland Haas -- Sonification : listen to brain activity / Gerald Baier, Thomas Hermann -- Chronobiology, as a foundation for and an approach to a new understanding of the influence of music / Hans-Ullrich Balzer -- Music as medicine : incorporating scalable music-based interventions into standard medical practice / Vera Brandes -- A perspective on evidence-based practice / Cheryl Dileo, Joke Bradt -- The audio-vocal system in song and speech development / Wilfried Gruhn -- The significance of exposure to music for the formation and stabilisation of complex neuronal relationship matrices in the human brain : implications for the salutogenetic effects of intervention by means of music theory / Gerald Hüther -- Music and the self / Petr Janata -- Neural substrates of processing syntax and semantics in music / Stefan Koelsch -- A city upon a hill : making scientific progress in brain-based music research in typical development, autism, and other disorders / Nicolas Lange, Janet E. Lainhart -- The rhythm of the heart, the tempus of music : Mozart, Ligeti, and the rat / Björn Lemmer -- Music and child neurology : a developmental perspective / Luisa Lopez -- Prenatal "experience" and the phylogenesis and ontogenesis of music / Richard Parncutt -- Music and the evolution of human brain function / Juan G. Roederer -- Clinical applications of music therapy in neurologic rehabilitation / Concetta M. Tomaino -- Human biochronology : on the source and functions of "musicality" / Colwyn Trevarthen -- A study of synchronisation behaviour in a group of test persons during Basky and Dhikr exercises via psycho-physiological monitoring / Gerhard Tucek, Elisabeth Ferstl, Florentina Maria Fritz -- Resonance and silence : the significance in medicine / Rolf Verres -- Emotion modulation by means of music and coping behaviour / Richard von Georgi, Miriam Göbel, Stefan Gebhardt -- Identifying the effectiveness of a music-based auditory stimulation method, on children with sensory integration and auditory processing concerns : a pilot study / John Esteves ... [et al.] -- Music as a medicine : incorporating music into standard hospital care / Vera Brandes.
  • 2007
    Sacks, Oliver W.
    Status: Not Checked OutLane Catalog Record
    Haunted by music. A bolt from the blue : sudden musicophilia ; A strangely familiar feeling : musical seizures ; Fear of music : musicogenic epilepsy ; Music on the brain : imagery and imagination ; Brainworms, sticky music and catchy tunes ; Musical hallucinations -- A range of musicality. Sense and sensibility : a range of musicality ; Things fall apart : amusia and dysharmonia ; Papa blows his nose in G : absolute pitch ; Pitch imperfect : cochlear amusia ; In living stereo : why we have two ears ; Two thousand operas : musical savants ; An auditory world : music and blindness ; The key of clear green : synesthesia and music -- Memory, movement, and music. In the moment : music and amnesia ; Speech and song : aphasia and music therapy ; Accidental davening : dyskinesia and cantillation ; Come together : music and Tourette's Syndrome ; Keeping time : rhythm and movement ; Kinetic melody: Parkinson's disease and music therapy -- Phantom fingers: the case of the one-armed pianist ; Athletes of the small muscles : musician's dystonia -- Emotion, identity, and music. Awake and asleep : musical dreams ; Seduction and indifference ; Lamentations : music and depression ; The case of Harry S. : music and emotion ; Irrepressible : music and the temporal lobes ; A hypermusical species : Williams Syndrome ; Music and identity : dementia and music therapy.
  • 2007 Springer
    Crossman, E. J.; Diana, James S.; Margenau, Terry.
  • 2005 Springer
    Stäbler, Axel.
  • 2008 ebrary
    Ali-Karamali, Sumbul.
    Everyday Islam: How Muslims Practice Their Religion -- Some Basic Islamic Concepts and How Islam Fits in to the Judeo-Christian Tradition -- The Story of an Arab, an Angel, and the God of Abraham: Muhammad and the Birth of Islam -- The Qur'an: What It Is and Why Quoting It Can Be Problematic -- Who's Who in Islam: From Ayatollahs to Whirling Dervishes -- Religious Hierarchy: Who Makes the Rules in Islam? -- Women in Islam: Marriage, Divorce, Polygamy, and that Veil Thing -- Jihad and Fundamentalism: Not the Same -- Theft and Adultery in Islam: Reflections on Disney's Aladdin -- An American Muslim Reaction to September 11th -- Why the Misconceptions Persist: Separating the Reality from the Murky Mythology.
  • 2014 Springer
    Deb, Sumitra; Deb, Swati Palit.
    This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
  • 2005/2006
    Riddle, Erica Delores.
    Status: Not Checked OutLane Catalog Record
  • 2013
    Stossel, Scott.
    Status: Not Checked OutLane Catalog Record
    The author recounts his lifelong battle with anxiety, showing the many manifestations of the disorder as well as the countless treatments that have been developed to counteract it, and provides a history of the efforts to understand this common form of mental illness.
  • 2005 NCBI Bookshelf
    "This book contains information on how to use My NCBI, a tool developed by the National Center for Biotechnology Information (NCBI) that replaces a previous feature called Cubby. This documentation is part of a growing collection of searchable help documents being produced for several resources available at NCBI."
  • 2009
    Taylor, Jill Bolte.
    Status: Not Checked OutLane Catalog Record
    On December 10, 1996, Taylor, a brain scientist, experienced a massive stroke. She observed her own mind deteriorate. Now she shares her unique perspective on the brain and its capacity for recovery.
  • 2012
    Engel, Andrew G.
    Status: Not Checked OutLane Catalog Record
    The anatomy and molecular architecture of the neuromuscular junction / Andrew G. Engel -- Electrodiagnosis of myasthenic disorders / Michel Harper -- The immunopathogenesis of myasthenia gravis / Reinhard Hohlfeld, Hartmut Wekerle, and Alexander Marx -- Natural history of myasthenia gravis / Vladimir Luchanok and Henry J. Kaminski -- The diagnosis of myasthenia gravis and other disorders of neuromuscular transmission / James F. Howard -- Therapy of myasthenia gravis / Daniel B. Drachman -- The Lambert-Eaton myasthenic syndrome / Vern C. Juel and Donald B. Sanders -- Congenital myasthenic syndromes / Andrew G. Engel ... [et al.] -- End-plate acetylcholine receptor : a target for myasthenic disorders : structural and mechanistic essentials / Steven M. Sine and Andrew G. Engel -- Peripheral nerve hyperexcitability syndromes / Srikanth Muppidi and Steven Vernino -- Effects of antiganglioside antibodies at the neuromuscular junction / Jaap J. Plomp and Hugh J. Willison.
  • 2009 Springer
    Kaminski, Henry J.
    Neuromuscular junction physiology and pathophysiology / Eroboghene E. Ubogu and Robert L. Ruff -- Acetylcholine receptor structure / Jon M. Lindstrom -- Immunopathogenesis of myasthenia gravis / Bianca M. Conti-Fine ... [et al.] -- Epidemiology and genetics of myasthenia gravis / Jeremiah W. Lanford, Lawrence H. Phillips -- Clinical presentation and epidemiology of myasthenia gravis / Jan B.M. Kuks -- Ocular myasthenia / Robert B. Daroff and Michael Benatar -- Thymoma-associated paraneoplastic myasthenia gravis / Philipp Ströbel, Wen-Yu Chuang, and Alexander Marx -- Electrodiagnosis of neuromuscular junction disorders / Bashar Katirji -- Autoantibody testing in the diagnosis and management of autoimmune disorders of neuromuscular transmission and related diseases / Mark A. Agius, David P. Richman, and Angela Vincent -- Treatment of myasthenia gravis / Henry J. Kaminski -- Neurocritical care of myasthenic crisis / J. Americo Fernandes Filho and Jose I. Suarez -- Thymectomy for non-thymomatous MG / Alfred Jaretzki III and Joshua R. Sonett -- Lambert-Eaton syndrome / Charles M. Harper, Vanda A. Lennon -- Acquired neuromyotonia -- Angela Vincent and Ian Hart -- Congenital myasthenic syndromes / David Beeson -- Toxic neuromuscular transmission disorders / James F. Howard, Jr. -- The impact of myasthenia gravis on mood, cognitive function, and quality of life / Robert H. Paul, Larry L. Mullins, and James M. Gilchrist -- Myasthenia gravis : classification and outcome measurements / Gil I. Wolfe and Richard J. Barohn.
  • 2013 Springer Protocols
    Sodir, Nicole M.; Soucek, Laura.
  • 2006 Springer
    Eisenman, Robert N.
    Making Myc / J. Liu and D. Levens -- Transcriptional activation by the Myc oncoprotein / M. D. Cole and M. A. Nikiforov -- Mechanisms of transcriptional repression by Myc / D. Kleine-Kohlbrecher, S. Adhikary and M. Eilers -- The mad side of the Max network : antogonizing the function of Myc and more / S. Rottmann and B. Luscher -- Structural aspects of interactions with the Myc/Max/Mad network / S. K. Nair and S. K. Burley -- Myc target transcriptomes / L. A. Lee and C. V. Dang -- c-Myc, genome instability, and tumorigenesis : the devil is in the details / M. Wade and G. M. Wahl -- Lessons learned from Myc/Max/Mad knockout mice / M. Pirity, J. K. Blanck and N. Schreiber-Agus -- Myc/Max/Mad in invertebrates : the evolution of the Max network / P. Gallant -- The mix network : evidence for a parallel Max-like transcriptional network that regulates energy metabolism / A. N. Billin and D. E. Ayer.
    Also available: Print – 2006
  • 2008 Springer Protocols
    Brown, Amanda Claire; Parish, Tanya.
    Isolation of Mycobacterium species genomic DNA / John T. Belisle, Spencer B. Mahaffey, and Preston J. Hill -- Isolation of mycobacterial RNA / Tige R. Rustad [and others] -- Lipoglycans of Mycobacterium tuberculosis : isolation, purification, and characterization / Libin Shi, Jordi B. Torrelles, and Delphi Chatterjee -- Analyzing lipid metabolism : activation and [beta]-oxidation of fatty acids / Paul Robert Wheeler -- Whole genome analysis using microarrays / S.J. Waddell, J. Hinds, and P.D. Butcher -- Use of DNA microarrays to study global patterns of gene expression / Roberta Provvedi, Giorgio Palù, and Riccardo Manganelli -- Two-dimensional gel electrophoresis-based proteomics of mycobacteria / Jens Mattow [and others] -- Transport assays and permeability in pathogenic mycobacteria / Marie-Antoinette Lanéelle and Mamadou Daffé -- Continuous culture of mycobacteria / Joanna Bacon and Kim A. Hatch -- Measuring minimum inhibitory concentrations in mycobacteria / Frederick A. Sirgel, Ian J.F. Wiid, and Paul D. van Helden -- Rapid screening of inhibitors of Mycobacterium tuberculosis growth using tetrazolium salts / Anita G. Amin [and others] -- Electroporation of mycobacteria / Renan Goude and Tanya Parish -- Ins and outs of mycobacterial plasmids / Farahnaz Movahedzadeh and Wilbert Bitter -- The use of temperature-sensitive plasmids in mycobacteria / Damien Portevin, Wladimir Malaga, and Christophe Guilhot -- Heterologous expression of genes in mycobacteria / James A. Triccas and Anthony A. Ryan -- Inducible expression systems for mycobacteria / Christopher M. Sassetti -- Assaying promoter activity using LacZ and GFP as reporters / Paul Carroll and Jade James -- Construction of unmarked deletion mutants in mycobacteria / Houhui Song, Frank Wolschendorf, and Michael Niederweis -- Construction of targeted mycobacterial mutants by homologous recombination / Sharon L. Kendall and Rosangela Frita -- Phage transposon mutagenesis / M. Sloan Siegrist and Eric J. Rubin -- Gene essentiality testing in Mycobacterium smegmatis using specialized transduction / Apoorva Bhatt and William R. Jacobs, Jr. -- Gene switching and essentiality testing / Amanda Claire Brown -- Insertion element IS6110-based restriction fragment length polymorphism genotyping of Mycobacterium tuberculosis / Robin M. Warren, Paul D. van Helden, and Nicolaas C. Gey van Pittius -- Typing Mycobacterium tuberculosis using variable number tandem repeat analysis / T.J. Brown, V.N. Nikolayevskyy, and F.A. Drobniewski -- Molecular detection of drug-resistant Mycobacterium tuberculosis with a scanning-frame oligonucleotide microarray / Dmitriy V. Volokhov [and others] -- MycoDB : an online database for comparative genomics of the mycobacteria and related organisms / Roy R. Chaudhuri -- Environmental amoebae and mycobacterial pathogenesis / Melanie Harriff and Luiz E. Bermudez.
  • 2015 Springer Protocols
    Parish, Tanya; Roberts, David M.
    Whole-genome sequencing for comparative genomics and de novo genome assembly / Andrej Benjak, Claudia Sala, and Ruben C. Hartkoorn -- Whole-transcriptome sequencing for high-resolution transcriptomic analysis in mycobacterium tuberculosis / Andrej Benjak, Claudia Sala, and Ruben C. Hartkoorn -- RNA sequencing for transcript 5'-end mapping in mycobacteria / Scarlet S. Shell [and 3 otherst] -- Fractionation and analysis of mycobacterial proteins / Megan C. Lucas [and 6 others] -- Lipid and lipoarabinomannan isolation and characterization / Marie-Antoinette Lanéelle, Jérôme Nigou, and Mamadou Daffé -- Metabolomics of mycobacterium tuberculosis / Madhumitha Nandakumar [and 3 others] -- Electroporation of mycobacteria / Renan Goude, David M. Roberts, and Tanya Parish -- Targeted gene knockout and essentiality testing by homologous recombination / Krishnamoorthy Gopinath, Digby F. Warner, and Valerie Mizrahi -- Construction of conditional knockdown mutants in mycobacteria / Dirk Schnappinger, Kathryn M. O'Brien, and Sabine Ehrt -- Mycobacterial recombineering / Kenan C. Murphy, Kadamba Papavinasasundaram, and Christopher M. Sassetti -- In vitro models that utilize hypoxia to induce non-replicating persistence in mycobacteria / Charles D. Sohaskeyand Martin I. Voskuil -- Genetic dissection of mycobacterial biofilms / Anil K. Ojha, William R. Jacobs Jr., and Graham F. Hatfull -- Measuring efflux and permeability in mycobacteria / Liliana Rodrigues, Miguel Viveiros, and José A. Aínsa -- Single-cell analysis of mycobacteria using microfluidics and time-lapse microscopy / Neeraj Dharand and Giulia Manina -- Antimicrobial susceptibility testing for Mycobacterium sp. / Delia Blanco-Ruano [and 6 others] -- Determination of compound kill kinetics against mycobacterium tuberculosis / Julie Early and Torey Alling -- Microplate alamar blue assay (MABA) and low oxygen recovery assay (LORA) for mycobacterium tuberculosis Sanghyun Cho, Hyung Sup Lee, and Scott Franzblau -- Multi-stress model for high throughput screening against non-replicating mycobacterium tuberculosis / Ben Gold, Thulasi Warrier, and Carl Nathan -- Isolation and characterization of compound-resistant isolates of mycobacterium tuberculosis / Theresa O'Malley and Eduard Melief -- Macrophage infection models for mycobacterium tuberculosis / Benjamin K. Johnson and Robert B. Abramovitch -- Infection of human neutrophils to study virulence properties of mycobacterium tuberculosis / Tobias Dallenga, Björn Corleis, and Ulrich E. Schaible -- Isolation of bead phagosomes to study virulence function of M. tuberculosis cell wall lipids / Anna C. Geffken, Emmanuel C. Patin, and Ulrich E. Schaible -- Live imaging of mycobacterium marinum infection in dictyostelium discoideum / Caroline Barisch, Ana T. López-Jiménez, and Thierry Soldati -- Testing chemical and genetic modulators in mycobacterium tuberculosis infected cells using phenotypic assays / Vincent Delorme [and 3 others].
  • 1980/9999
    Grange, John M.
    Status: Not Checked OutLane Catalog Record
  • Springer Protocols
    Parish, Tanya; Stoker, Neil G.
    Plasmid vectors / N. Casali and S. Ehrt -- Isolation of DNA from Mycobacterium tubercolosis / P.D. Helden [and others] -- Extraction of RNA from intracellular Mycobacterium tuberculosis / I.M. Monahan, J.A. Mangan and P.D. Butcher -- Transposon mutagenesis in mycobacteria using conditionally replicating mycobacteriophages / S.S. Bardarov, S.S. Bardarov and W.R. Jacobs -- Gene replacement and transposon delivery using the negative selection marker sac B / M. Jackson [and others] -- Gene replacement using pretreated DNA / B.G. Gordhan and T. Parish -- Gene replacement in Mycobacterium tuberculosis and Mycobacterium bovis BCG using rpsl as a dominant negative selectable marker / P. Sander, B. Springer and E.C. Böttger -- Transcription start-site mapping / F. Movahedzadeh, J.A. Gonzalez-Y-Merchand and R.A. Cox -- Fluorescence and Brightfield cytology of live M. tuberculosis cells / R.P. Cooney, N.J. Garton and M.R. Barer -- Phage replication technology for diagnosis and drug susceptibility testing / R. McNerney -- Detection of mutations in Mycobacterium tuberculosis by a dot blot hybridization strategy / T.C. Victor and P.D. Helden -- Restriction fragment length polymorphism typing of mycobacteria / D. Soolingen, P.E.W. Haas and K. Kremer -- Preparation of culture filtrate proteins from Mycobacterium tuberculosis / I. Rosenkrands and P. Andersen -- Analysis of the capsule of Mycobacterium tuberculosis / M. Daffé and M.-A. Lanée -- Analysis of the lipids of Mycobacterium tuberculosis / R.A. Slayden and C.E. Barry -- In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis / L.G. Wayne -- 17 macrophage virulence assays / P.T. Lukey and E.U. Hooker -- Analysis of mycobacterium -infected macrophages by immunoelectron microscopy and cell fractionation / W. Beatty and D.G. Russell -- Real time PCR using molecular beacons / R. Manganelli, S. Tyagi and I. Smith -- Electronic access to Mycobacterium tuberculosis sequence data / J. Parkhill -- Proteomics / J.C. Betts and M.A. Smith -- Functional genomics of Mycobacterium tuberculosis using DNA microarrays / M. Wilson [and others] -- Storage of mycobacterial strains / K. Kremer, T. Laan and D. Soolingens -- Safety in the laboratory / H. Alderton and D. Smith.
  • v. 1, 4, [5], 6, 8-10, 13-15, 2006-12. Springer
    Also available: Print – v. 6, 1996.
  • Springer Protocols
    Pohland, Albert E.; Trucksess, Mary W.
    pt. 1. General techniques -- Mycotoxin method evaluation: an introduction -- Sampling techniques -- Preparatory isolation of mycotoxins from solid phase fungal cultures -- Preparation of mycotoxin standards -- Electrospray mass spectrometry for mycotoxin detection and purity analysis -- pt. 2. Methods for aspergillus toxins -- Measurement of aflatoxins using capillary electrophoresis -- Immunochemical method for cyclopiazonic acid -- Immunochemical method for ochratoxin A -- pt. 3. Methods for fusarium toxins -- Solution fluorometric method for deoxynivalenol in grains -- Chromatographic method for trichothecenes -- Chromatographic method for the determination of the mycotoxin moniliformin in corn -- Liquid chromatographic method for fumonsins in corn -- Enzyme-linked immunosorbent assays of zearalenone using polyclonal, monoclonal, and recombinant antibiodies -- pt. 4. Methods for other fungal toxins -- Chromatographic method for stachybotrys toxins -- Immunochemical method for citrinin -- Solid phase extraction method for patulin in apple juide and unfiltered apple juice -- Liquid chromatographic method for the determination of ergot alkaloids in cereal grains -- Chromatographic method for alternaria toxins in apple juice -- Index.
  • 2004 ScienceDirect
    Lazzarini, Robert A.
    v. 1. Biology -- v. 2. Disorders.
    Also available: Print – v. 1-2., 2004
  • 2013 Springer
    Duncan, I. D.; Franklin, Robin J. M.
    Development of Oligodendrocytes in the Vertebrate CNS / Robert H. Miller -- Demyelination and Remyelination in Multiple Sclerosis / Lars Bø, Margaret Esiri, Nikos Evangelou and Tanja Kuhlmann -- Microglial Function in MS Pathology / Trevor J. Kilpatrick and Vilija G. Jokubaitis -- Endogenous Remyelination in the CNS / Robin J. M. Franklin, Chao Zhao, Catherine Lubetzki and Charles ffrench-Constant -- Exogenous Cell Myelin Repair and Neuroprotection in Multiple Sclerosis / Ian D. Duncan and Yoichi Kondo -- A Peripheral Alternative to Central Nervous System Myelin Repair / V. Zujovic and A. Baron Van Evercooren -- Immune Modulation and Repair Following Neural Stem Cell Transplantation / Tamir Ben-Hur, Stefano Pluchino and Gianvito Martino -- Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis / Joel A. Black, Kenneth J. Smith and Stephen G. Waxman -- Effects of Current Medical Therapies on Reparative and Neuroprotective Functions in Multiple Sclerosis / Jack P. Antel and Veronique E. Miron -- Imaging of Demyelination and Remyelination in Multiple Sclerosis / Douglas L. Arnold, Catherine M. Dalton, Klaus Schmierer, G. Bruce Pike and David H. Miller -- Designing Clinical Trials to Test Neuroprotective Therapies in Multiple Sclerosis / P. Connick, M. Kolappan, A. Compston and S. Chandran.
  • 2013 Springer
    Xu, Ke; Terakawa, S.
    In 1961, neurobiologists found that the conduction velocity of the nerve impulse in the giant nerve fiber of the Penaeus shrimp abdominal nerve cord was over 200 m/s, the highest speed of information transmission ever observed in the animal kingdom. The peculiar myelin sheath with its unique nodal structure and the electrical properties of the nerve fibers of the shrimp have continued to be investigated for a quarter of century and are now fully described in this book. The investigation dispels the commonly held belief that the fastest recorded impulse conduction is about 120 m/s in the thickest vertebrate myelinated nerve fibers. In the shrimp, researchers found a completely novel type of functional node in the giant fiber which they designated as the fenestration node. In portions of the myelinated fiber, the fenestration node furnished the sites of excitation. Also discovered was a new strategy for increasing impulse conduction in the shrimp. The book includes a section on the formation of the fenestration node and the discovery of a strategy that allows the shrimp to escape its predators by an action of the fastest velocity. The data presented in this volume on the myelin sheath of invertebrates present a new direction for this field and a rich source of information for neurobiologists worldwide.
  • 2006
    Greenberg, Peter L.
    Status: Not Checked OutLane Catalog Record
    Clinical and prognostic characterization of myelodysplastic syndromes / Peter L. Greenberg -- Morphologic classifications of myelodysplastic syndromes : French-American-British (FAB) and World Health Organization (WHO) / Richard D. Brunning -- Pathogenetic mechanisms underlying myelodysplastic syndromes / Peter L. Greenberg -- Cytogenetic abnormalities in myelodysplastic syndromes / Harold J. Olney and Michelle M. Le Beau -- Molecular mechanisms and gene expression patterns in myelodysplastic syndromes / Wolf-Karsten Hofmann and H. Phillip Koeffer -- Immunologic mechanisms and treatment of myelodysplastic syndromes / A. John Barrett, Elaine Sloand and Neal S. Young -- Biologically targeted therapies for myelodysplastic syndromes / Andrew J. Buresh and Alan F. List -- Supportive care in myelodysplastic syndromes : hemopoietic cytokine and iron chelation therapy / Jason Gotlib and Peter L. Greenberg -- Hematopoietic cell transplantation for myelodysplastic syndromes / H. Joachim Deeg and Bart Scott -- Health-related quality of life in myelodysplastic syndromes : conceptualization, measurement, and implications for research and practice / Mary Laudon Thomas.
  • 2013 Springer
    Deeg, H. J.
    Part I. Epidemiology and clinical presentation -- Clinical presentation and differential diagnosis -- Epidemiology and etiology -- Part II. Pathology, pathophysiology and staging -- Cytogenetic diagnosis of myelodysplastic syndromes -- MDS stem cell biology -- The biology of myelodysplastic syndrome associated with Isolated del(5q) -- A personalized molecular pathogenesis of MDS -- Myelodysplastic/myeloproliferative neoplasms -- Classification and staging of myelodysplastic syndromes -- Immunophenotyping in myelodysplastic syndromes -- Prognostic models for patients with myelodysplastic syndromes -- Part III. Treatment -- Management of low-risk MIDS -- Management of high-risk myelodysplastic syndrome -- Hematopoietic cell transplantation (HCT) -- Part IV. MIDS in children -- Myelodysplastic syndrome in children.
  • 2005 Springer Protocols
    Hertzberg, Mark; Iland, Harry; Marlton, Paula.
    Diagnosis and monitoring of AML1-MTG8 (ETO)-positive acute myeloid leukemia by qualitative and real-time quantitative RT-PCR / Khalid Tobal and John A. Liu Yin -- Diagnosis and monitoring of CBFB-MYH11-positive acute myeloid leukemia by qualitative and quantitative RT-PCR / Bert A. van der Reijden and Joop H. Jansen -- Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia / Jan Cools, Elizabeth H. Stover, and D. Gary Gilliland -- FLT3 mutations in acute myeloid leukemia / Hitoshi Kiyoi and Tomoki Naoe -- WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes / Daniela Cilloni, Enrico Gottardi, and Giuseppe Saglio -- Classification of AML by DNA-oligonucleotide microarrays / Alexander Kohlmann ... [et al.] -- Classification of AML using a monoclonal antibody microarray / Richard I. Christopherson ... [et al.] -- Isolation of RNA and DNA from leukocytes and cDNA synthesis / Joop H. Jansen and Bert A. van der Reijden -- Cytogenetics and FISH techniques in myeloid malignancies / Lynda J. Campbell -- Overview of real-time RT-PCR strategies for quantification of gene rearrangements in the myeloid malignancies / Christophe Picard, Monique Silvy, and Jean Gabert -- Diagnosis and monitoring of chronic myeloid leukemia by qualtitative and quantitative RT-PCR / Susan Branford and Timothy Hughes -- Detection of BCR-ABL mutations and resistance to imatinib mesylate / Susan Branford and Timothy Hughes -- Deletion of the derivative chromosome 9 in chronic myeloid leukemia / Lynda J. Campbell -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR / Vincenzo Rossi, Laura Levati, and Andrea Biondi -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by quantitative RT-PCR / Elisa Mokany ... [et al.] -- Methods for the detection of the JAK2 V617F mutation in human myeloproliferative disorders / Peter J. Campbell ... [et al.] -- Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia / Maurizio Martini, Luciana Teofili, and Luigi M. Larocca -- Chimerism analysis following nonmyeloablative stem cell transplantation / Thomas Lion and Franz Watzinger.
  • 2010 Springer
    Roodman, G. David.
    Clinical Presentation of Myeloma Bone Disease / Rebecca Silbermann and G. David Roodman -- Imaging of Multiple Myeloma, Solitary Plasmacytoma, MGUS, and Other Plasma Cell Dyscrasias / Ronald C. Walker, Laurie Jones-Jackson, Twyla Bartel, Tracy Brown and Bart Barlogie -- Biochemical Markers of Bone Remodeling in Multiple Myeloma / Evangelos Terpos -- Radiation Therapy in Multiple Myeloma / Joel S. Greenberger -- Surgical Management of Bone Disease / Mohamad A. Hussein -- Bisphosphonates in the Treatment of Myeloma Bone Disease / James R. Berenson -- Osteonecrosis of the Jaw / Ashraf Badros -- Murine Models of Myeloma Bone Disease: The Importance of Choice / Peter I. Croucher, Karin Vanderkerken, Joshua Epstein and Babatunde Oyajobi -- RANK Ligand Is a Therapeutic Target in Multiple Myeloma / William C. Dougall, Michelle Chaisson-Blake, Howard Yeh and Susie Jun -- Osteoclast Activation in Multiple Myeloma / Sonia Vallet and Noopur Raje -- Potential Role of IMiDs and Other Agents as Therapy for Myeloma Bone Disease / Suzanne Lentzsch -- Proteasome Inhibitors and the Wnt Signaling Pathway in Myeloma Bone Disease / Claire M. Edwards and Gregory R. Mundy -- Mechanisms Involved in Osteoblast Suppression in Multiple Myeloma / Nicola Giuliani.
  • 2012 Springer
    Barbui, T.; Tefferi, Ayalew.
    Myeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of these diseases have arisen following the discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative MPNs. This book comprises evidence-based reviews and expert consensus results. It offers comprehensive coverage of relevant laboratory and clinical advances and places great emphasis on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.
  • 2011 Springer
    Tefferi, Ayalew; Verstovsek, Srdan.
    Diagnosis and classification of the BCR-ABL1-negative myeloproliferative neoplasms -- Genetics of the myeloproliferative neoplasms -- Cytogenetic findings in classical MPNs -- Prognostic factors in classic myeloproliferative neoplasms -- Therapy of polycythemia vera and essential thrombocythemia -- Conventional and investigational therapy for primary myelofibrosis -- Hematopoietic cell transplantation for myelofibrosis -- JAK2 inhibitors for therapy of myeloproliferative neoplasms -- Blastic transformation of classic myeloproliferative neoplasms -- Eosinophilic disorders: differential diagnosis and management -- Pathogenesis, diagnosis, classification, and management of systemic mastocytosis.
  • 2001 HighWire
    Also available: Print – 2001
  • 2006 Springer
    Cokkinos, Dennis V.
    Also available: Print – 2006
  • 2013 ScienceDirect
    Irnich, Dominik.
    Edited by Dominik Irnich, MD, this clearly written and fully illustrated multi-contributor volume offers practical, comprehensive coverage of the subject area ranging from the latest scientific research findings to practical usage of current manual therapy techniques. Including the latest information from centres of excellence throughout the world, this new book is suitable for osteopathic physicians, osteopaths, chiropractors, manual therapists, physiotherapists, acupuncturists and massage therapists as well as general physicians working in primary care, physical medicine, rehabilitation, pain management and internal medicine. Offers practical and clinically relevant information to all practitioners and therapists working in the field Edited by an international expert in pain management and trigger point therapy Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Carefully prepared by a worldwide team of clinically active and research oriented contributors to provide helpful and clinically relevant information Presents the latest research findings for many aspects of trigger point therapy Provides a holistic view of patient care including the importance of patient communication and psychological aspects of pain control Provides a handy reference for rapid and effective diagnosis and treatment of trigger points Highlights the 65 most important muscles in a comprehensive practical style which includes anatomy, symptoms, pain patterns, physical examination and strategies for effective treatment Offers an ideal resource for training courses in trigger point injection, osteopathy, manual therapy and acupuncture Suitable for osteopathic physicians, osteopaths, chiropractors, manual therapists, acupuncturists and massage therapists as well as general physicians working in primary care, physical medicine, rehabilitation, pain management and internal medicine.
  • 2012 Springer Protocols
    DiMario, Joseph X.
    Isolation and characterization of human fetal myoblasts/ Ariya D. Lapan and Manuela Gussoni -- Skeletal muscle satellite cells : background and methods for isolation and analysis in a primary culture system / Maria Elena Danoviz and Zipora Yablonka-Reuveni -- Isolation of muscle stem cells by fluorescence activated cell sorting cytometry / Alessandra Pasut, Paul Oleynik, and Michael A. Rudnicki -- Mouse and human mesoangioblasts : isolation and characterization from adult skeletal muscles / Mattia Quattrocelli [and others] -- Direct electrical stimulation of myogenic cultures for analysis of muscle fiber type control / Eric J. Cavanaugh, Jennifer R. Crew, and Joseph X. DiMario -- Single muscle-fiber isolation and culture for cellular, molecular, pharmacological, and evolutionary studies / Judy E. Anderson, Ashley C. Wozniak, and Wataru Mizunoya -- Somite unit chronometry to analyze teratogen phase specificity in the paraxial mesoderm / Sarah J. Venters and Charles P. Ordahl -- Analysis of skeletal muscle development in drosophila / Ginny R. Morriss [and others] -- Immunocytochemistry to study myogenesis in zebrafish / Nathan C. Bird, Stefanie E. Windner, and Stephen H. Devoto -- Immunofluorescent localization of proteins in Caenorhabditis elegans muscle / Kristy J. Wilson, Hiroshi Qadota, and Guy M. Benian -- Resistance loading and signaling assays for oxidative stress in rodent skeletal muscle / Stephen E. Alway and Robert G. Cutlip -- Analysis of skeletal muscle hypertrophy in models of increased loading / Sue C. Bodine and Keith Baar -- Protein overexpression in skeletal muscle using plasmid-based gene transfer to elucidate mechanisms controlling fiber size / Chia-Ling Wu and Susan C. Kandarian -- In vivo measurement of muscle protein synthesis rate using the flooding dose technique / Marta L. Fiorotto, Horacio A. Sosa Jr., and Teresa A. Davis -- Recombinant adeno-associated viral vector production and purification / Jin-Hong Shin, Yongping Yue, and Dongsheng Duan -- Generation of lentiviral vectors for use in skeletal muscle research / Christophe Pichavant and Jacques P. Tremblay -- Generating tamoxifen-inducible Cre alleles to investigate myogenesis in mice / Christoph Lepper and Chen-Ming Fan -- Gene profiling studies in skeletal muscle by quantitative real-time polymerase chain reaction assay / Shephali Bhatnagar, Siva K. Panguluri, and Ashok Kumar -- Analysis of lipid profiles in skeletal muscles / Vassilis Mougios and Anatoli Petridou -- Proteomic analysis of dystrophic muscle / Caroline Lewis, Philip Doran, and Kay Ohlendieck -- Detection of calcium release via ryanodine receptors / Jerry P. Eu and Gerhard Meissner -- Measurement of calcium release due to inositol trisphosphate receptors in skeletal muscle / Mariana Casas, Francisco Altamirano, and Enrique Jaimovich -- Detection of calcium sparks in intact and permeabilized skeletal muscle fibers / Noah Weisleder, Jingsong Zhou, and Jianjie Ma -- Analysis of calcium transients in cardiac myocytes and assessment of the sarcoplasmic reticulum Ca(2+)-ATPase contribution / Anand Mohan Prasad and Giuseppe Inesi -- Analysis of muscle gene transcription in cultured skeletal muscle cells / Charis L. Himeda, Phillip W.L. Tai, and Stephen D. Hauschka -- Analysis of fiber-type differences in reporter gene expression of [beta]-gal transgenic muscle / Phillip W.L. Tai [and others] -- Determination of gene promoter activity in skeletal muscles in vivo / Sarah M. Senf and Andrew R. Judge -- Determination of miRNA targets in skeletal muscle cells / Zhan-Peng Huang, Ramón Espinoza-Lewis, and Da-Zhi Wang -- ShRNA-mediated gene knockdown in skeletal muscle / Muriel Golzio, Jean-Michel Escoffre, and Justin Teissié -- Detection of NF-[kappa]B activity in skeletal muscle cells by electrophoretic mobility shift analysis / Jason M. Dahlman and Denis C. Guttridge -- Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays / Yasuyuki Ohkawa [and others] -- An improved restriction enzyme accessibility assay for analyzing changes in chromatin structure in samples of limited cell number / Yasuyuki Ohkawa [and others] -- ChIP-enriched in silico targets (ChEST), a ChIP-on-chip approach applied to analyzing skeletal muscle genes / Guillaume Junion and Krzysztof Jagla.
  • 2007 ScienceDirect
    Hilton-Jones, David; Mastaglia, Frank L.
    Also available: Print – 2007
  • 2013
    Ingle, Sadie Rae Bartholomew; Pfeffer, Suzanne R.; Spudich, James A.; Straight, Aaron.
    The eukaryotic actin and microtubule cytoskeleton is extremely dynamic and complex. Actin and microtubule filaments, together with their accessory proteins, perform structural roles and provide tracks for molecular motors to move along. Converting chemical energy released upon nucleotide hydrolysis into mechanical work, molecular motors provide the driving force behind most non-Brownian movement within a eukaryotic cell. Myosins are a type of molecular motor that undergo conformational changes upon the hydrolysis of ATP and product release that enables them to translate along actin filaments. Myosin motors are responsible for the sliding of actin filaments during muscle contraction, as well as transport and anchoring of organelles, vesicles, and other intracellular components (Hartman et al., 2011). Identified for its role in muscle contraction, muscle myosin II (MII) hydrolyzes ATP to generate force and drive the sliding of actin filaments in the sarcomere (Huxley and Niedergerke, 1954; Huxley and Hanson, 1954). MII functions in both skeletal and cardiac muscle, and is responsible for the muscle contraction, isometric force generation, and the contraction force associated with each heartbeat. In myocytes, MII is highly organized with about a dozen other proteins into sarcomeric units that form a near crystalline structure and comprise about 50% of myocyte volume. Availability of MII binding sites along the actin filament is regulated by MII accessory proteins in a Ca2+-dependent manner. Thus, MII-generated force and muscle contraction is dependent upon intracellular Ca2+ concentration and cooperation of accessory proteins. Human mutations in MII or its accessory proteins can yield a variety of disease states, depending on the mutated protein and the tissue in which it is expressed. In this work, we characterize four different mutations in the MII accessory protein troponin I that cause hypertrophic cardiomyopathy (HCM). A condition affecting approximately 1 in 500 individuals in the United States, the underlying mechanisms of HCM remain elusive (Maron et al., 1995a). Using a six-component system, we reconstituted the sarcomere in vitro and examined biochemical properties of the system with wild type and mutant troponin I protein. We found that three of the four mutations significantly increase the affinity of regulated actin ("regulated thin filament") for Ca2+. The fourth mutation we examined did not affect the affinity of the system for Ca2+, but rather affected the mechanochemical cycle of the MII motor. Because no therapeutics currently exist to treat the underlying causes of HCM, these studies highlight the complexities underlying HCM and the importance of understanding the complete biochemical and biophysical nature of the mutations that cause it. We next explore the role of myosin Va (MVa) and its accessory proteins in neuronal function. Mice expressing mutant MVa have marked neurological defects and die prematurely (Mercer et al., 1991). While new biological roles of MVa are emerging, it is likely that there are many that are yet to be discovered. To identify novel MVa functions, we chose to determine the proteins to which it binds in the cell. Affinity chromatography was used to ascertain candidate MVa binding partners from brain extract. Each candidate was tested for direct binding, and the protein spire1 was found to be a direct binder to MVa. Spire1 is an actin nucleator that was originally identified in Drosophila, and few mammalian functional studies had been performed at the start of this work. We serendipitously amplified a novel isoform of spire1 from mouse brain cDNA that targeted to mitochondria. Additional work with MVa-null mice showed that this mitochondrial localization was independent of MVa, and any potential role spire1 may play in mediating mitochondrial dynamics or homeostasis is also MVa-independent. Detailed analysis of mammalian spire1 isoforms showed that at least 3 exons are differentially-spliced to form spire1 of various compositions. Interested in the potential functional differences among isoforms, we created spire1 constructs lacking each of the 3 alternate exons, and found alternate exon C to be necessary and sufficient for mitochondrial localization of spire1. After confirming the expression of exon C-containing spire1 in multiple mouse tissues, we probed functional roles for spire1 by expressing different truncations in mammalian cells. We identified a striking mitochondrial phenotype that strongly suggests spire1 mediates mitochondrial fission and/or fusion in an actin-dependent manner. Finally, we studied the biochemical link between spire1 and mitochondria. We found alternate exon C to bind directly and specifically to cardiolipin, a mitochondrial-specific lipid in eukaryotes. We performed affinity chromatography to look for potential proteins that interact with exon C and tether it to mitochondria, but the purified spire1 protein with which we were working was not tractable for these experiments. This work highlights the similarities and differences between two different myosins, their accessory proteins, and their diverse biological functions.
  • 2008 Springer
    Coluccio, Lynne M.
    The structural and functional diversity of the myosin family of actin-based molecular motors / M.S. Mooseker and B.J. Foth -- Myosin structure / K.C. Holmes -- The myosin family: Biochemical and kinetic properties / M. El-Mezgueldi and C.R. Bagshaw -- Myosin I / L.M. Coluccio -- Myosin II : Sarcomeric myosins, the motors of contraction in cardiac and skeletal muscles / C. Reggiani and R. Bottinelli -- Smooth-muscle myosin II / C.R. Cremo and D.J. Hartshorne -- Non-muscle myosin II / M. Conti, S. Kawamoto and R.S. Adelstein -- Class III myosins / A. Dosé, J. Lin-Jones and B. Burnside -- Myosin V / J.R. Sellers and L.S. Weisman -- Myosin VI : A multifunctional motor protein / F. Buss and J. Kendrick-Jones -- Myosin VII / A. El-Amraoui, A. Bahloul and C. Petit -- Plant myosins VIII, XI, and XIII / K. Yamamoto -- Class IX myosins / M. Bähler -- Myosin X / M.M. Divito and R.E. Cheney -- Myosin class XIV and other myosins in protists / K. Frénal, B.J. Foth and D. Soldati -- Myosin XVa / E.T. Boger ... [et al.].
  • ProQuest Safari
    DuBois, Paul.
    This book offers dozens of short, focused pieces of code and hundreds of worked-out examples for programmers of all levels who don't have the time or expertise to solve MySQL problems from scratch. Each recipe explains how and why the code works, so you'll learn as you. This new edition covers MySQL 5.0 and its powerful new features, along with the older but still widespread MySQL 4.1.
  • 2010 Karger
    Walusinski, Olivier.
    The first complete and authoritative book on yawning.

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Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.
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