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  • "As more original molecular protocols and subsequent modifications are described in the literature, it has become difficult for those not directly involved in the development of these protocols to know which are most appropriate to adopt for accurate identification of bacterial pathogens. Molecular Detection of Human Bacterial Pathogens addresses this issue, with international scientists in respective bacterial pathogen research and diagnosis providing expert summaries on current diagnostic approaches for major human bacterial pathogens. Each chapter consists of a brief review on the classification, epidemiology, clinical features, and diagnosis of an important pathogenic bacterial genus, an outline of clinical sample collection and preparation procedures, a selection of representative stepwise molecular protocols, and a discussion on further research requirements relating to improved diagnosis. This book represents a reliable and convenient reference on molecular detection and identification of major human bacterial pathogens; an indispensable tool for upcoming and experienced medical, veterinary, and industrial laboratory scientists engaged in bacterial characterization; and an essential textbook for undergraduate and graduate students in microbiology"--Provided by publisher.
  • Pt. 1. Ascomycota -- pt. 2. Bastidiomycota -- pt. 3. Entomohpthoromycotina and Muscoromyotina -- pt. 4. Microsporidia -- pt. 5. Oomycota, Chlorophyta, and Mesomycetozoea -- pt. 6. Panfungal and drug resistance detection.
  • "A book on the molecular detection of major human viral, bacterial, fungal, and parasitic pathogens, this text provides coverage of the organisms with an emphasis on the sample preparation and molecular detection procedures. Chapters consist of concise reviews of pathogens in respect to taxonomy, biology, epidemiology, and pathogenesis; a description of a clinical sample collection preparation procedures; a summary of molecular detection methods available; and a discussion on the challenges, limitations, and advantages for current methods. Written for practitioners and students, this textbook is a guide for future development of improved molecular methods for pathogens. Offers an in-depth review of state-of-the-art molecular detection and identification methods for human parasitic pathogens. Provides comprehensive coverage of important human parasitic pathogens. Provides an authoritative summary of biology, epidemiology, and pathogenesis of major human parasitic pathogens. Includes chapter entries written by experts in respective fields of human parasitic pathogen collection"--Provided by publisher.
  • Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor β (TGFβ); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive β-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.
  • H2AX in DNA Damage Response -- DNA Damage Signaling Downstream of ATM -- Checkpoint Control Following Radiation Exposure -- Chromatin Responses to DNA Damage -- Caenorhabditis elegans Radiation Responses -- Hypoxia and Modulation of Cellular Radiation Response -- Inhibitors of DNA Repair and Response to Ionising Radiation -- Gene Therapy and Radiation -- Molecular Targeted Drug Delivery Radiotherapy -- EGFR Signaling and Radiation -- Thermal Modulation of Radiation-Induced DNA Damage Responses -- Radiation-Induced Immune Modulation.
  • ch. 1. General concepts -- ch. 2. Fundamental principles of electron and energy transfer -- ch. 3. Wires and related systems -- ch. 4. Switching electron- and energy-transfer processes -- ch. 5. Light-harvesting antennae -- ch. 6. Photoinduced charge separation and solar energy conversion -- ch. 7. Bistable systems -- ch. 8. Multistate-multifunctional systems -- ch. 9. Logic gates -- ch. 10. Basic principles of molecular machines -- ch. 11. Spontaneous mechanical-like motions -- ch. 12. Movements related to opening, closing, and translocation functions -- ch. 13. Rotary movements -- ch. 14. Threading-dethreading movements -- ch. 15. Linear movements -- ch. 16. Motions in catenanes.
  • Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
  • Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets.
  • "This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers -- clinicians, pathologists, laboratorians, and other inquisitive minds -- independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing "excise and pray" approaches with personalized medicine."--Publisher's website.
  • Pt. I. Introduction. An historical perspective on the clinical diagnostic laboratory / Robert E. Moore -- Pt. II. Basic molecular biology. An overview of nucleic acid chemistry, structure, and function: the foundations of molecular biology / William B. Coleman -- Extraction of nucleic acids / Paul N. Bogner and Anthony A. Killeen -- Nucleic acid blotting techniques: theory and practice / Terry Amiss and Sharon collins Presnell -- The polymerase chain reaction / William B. Coleman and Gregory J. Tsongalis -- Bioinformatics: computer-based approaches to genetic analysis / Sharon L. Ricketts -- Pt. III. Molecular diagnostic technologies. PCR-based methods for mutation detection / Ian M. Frayling, Emma Monk, and Rachel Butler -- Alternative methods for amplified nucleic acid testing / Deborah A. Payne and Laurie E. Sower -- Electrophoretic methods for mutation detection and DNA sequencing / W. Edward Highsmith, Jr. -- Single-nucleotide polymorphisms: testing DNA variation for disease association / Ulrich Broeckel and Martin J. Hessner -- Microarray approaches to gene expression analysis / David Neil Hayes and Matthew Meyerson -- Methods for analysis of DNA methylation / Alexander Dobrovic -- Pt. IV. Other clinical diagnostic technologies / Flow Cytometry / Joseph A. DiGiuseppe -- Medical cytogenetics / Martha B. Kaegle -- Fluorescence In situ hybridization: a major milestone in luminous cytogenetics / Suneel D. Mundle and Robert J. Koska -- Immunohistochemistry / John Hunt ... [et al.] -- Lser capture microdissection / C. Robert Bagnell, Jr. -- Pt. V. Quality assurance in the molecular diagnostics laboratory. Framework for quality assurance in molecular diagnostics / Marlene Sabbath-Solitare, Selwyn J. Baptist, and Teresita Cuyegkeng Redondo -- Verification of molecular assays / Brent L. Seaton -- Standards and standardization of molecular diagnostics / John P. Jakupciak and Catherine D. O'Connell -- Laboratory-developed tests in molecular diagnostics / Andrea Ferreira-Gonzalez and Carleton T. Garrett -- Pt. VI. Applications of molecular diagnostics for genetic diseases. An overview of molecular genetics / Elaine Weidenhammer and Gregory J. Tsongalis -- Genetic basis of neurologic neuromuscular diseases / Narasimhan Nagan ... [et al.] -- Molecular mechanisms of endocrine disorders / Amy Potter and John A. Phillips III -- Molecular pathogenesis of cardiovascular disease / Alan H.B. Wu -- Molecular diagnostics in coagulation / Enrique Ballesteros -- Cystic fibrosis / Eugene H. Lewis III ... [et al.] -- Prenatal genotyping for identification of identification of fetuses at risk for immune cytopenic disorders / Martin J. Hessner and Brian R. Curtis -- Personalized medicine / Karen McCullough -- Pt. VII. Applications of molecular diagnostics for human cancers. Molecular pathogenesis of human cancer / William B. Coleman and Gregory J. Tsongalis -- Application of molecular diagnostics to hereditary nonpolyposis colorectal cancer / Ian M. Frayling ... [et al.] -- Molecular genetic applications to the diagnosis of lymphoma / William N. Rezuke, Jr. and Gregory J. Tsongalis -- Molecular genetic abnormalities in acute and chronic leukemias / Pei Lin and L. Jeffrey Medeiros -- Pt. VIII. Applications of molecular diagnostics for infectious diseases. Molecular testing for Chlamydia trachomatis and Neisseria gonorrhoeae / Alexandra Valsamakis -- Human Papillomavirus / Theresa M. Voytek and Gregory J. Tsongalis -- Molecular diagnosis for HIV-1 / Angela M. Caliendo and Charles E. Hill -- Hepatitis C / D. Robert Dufour -- Cytomegalovirus / Angela M. Caliendo and Nell S. Lurain -- Pt. IX. Applications of molecular diagnostics for identity-based testing. HLA typing using molecular methods / John L. Schmitz -- Molecular analysis for forensic casework and parentage testing / Tracey Dawson Cruz -- Molecular assessment of bone marrow transplant engraftment / Jessica K. Booker -- Use of DNA-based identity testing for specimen identification / Andrew Ricci Jr. and Gregory J. Tsongalis -- Pt. X. Issues for the clinical molecular pathology laboratory. Genetic counseling considerations in molecular diagnosis / Myra I. Roche -- Ethical, social, and legal issues related to molecular genetic testing / Jennifer L. Herbst and Jon F. Merz.
  • Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. This handbook provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting.
  • This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.The book is the first of its kind to cover relevant subjects around molecular cancer diagnostics when used as important drivers in personalized cancer medicine. The different chapters of the book are authored by key opinion leaders, each representing their specialized areas, which provide the reader with expertise knowledge in the field.
  • Chapter 1. Molecular Diagnostics: Past, Present, and Future / George P. Patrinos, Wilhelm J. Ansorge -- Chapter 2 . Allele-Specific Mutation Detection / Aglaia Athanassiadou, Eleana F. Stavrou, Adamandia Papachatzopoulou, George P. Patrinos -- Chapter 3. Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation / Chinh T. Bui, Emmanuelle Nicolas, Georgina Sallmann, Maria Chiotis, Andreana Lambrinakos, Kylee Rees, Ian Trounce, Richard G.H. Cotton, Lauryn Blakesley, Andrew K. Godwin, Anthony T. Yeung -- Chapter 4. Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis / Panayiotis G. Menounos, George P. Patrinos -- Chapter 5. Capillary Electrophoresis / Anja Bosserhoff, Claus Hellerbrand -- Chapter 6. Temperature and Denaturing Gradient Gel Electrophoresis / Hartmut Peters, Peter N. Robinson -- Chapter 7. Real-Time Polymerase Chain Reaction / Lut Overbergh, Anna-Paula Giulietti, Dirk Valckx, Chantal Mathieu -- Chapter 8 - Pyrosequencing / Sharon Marsh -- Chapter 9. Application of Padlock and Selector Probes in Molecular Medicine / Mats Nilsson, Chatarina Larsson, Johan Stenberg, Jenny Göransson, Ida Grundberg, Magnus Isaksson, Tim Conze, Sara Henriksson -- Chapter 10. Molecular Cytogenetics in Molecular Diagnostics / Holger Tönnies -- Chapter 11. Analysis of Human Splicing Defects Using Hybrid Minigenes / Franco Pagani, Francisco E. Baralle -- Chapter 12. Detection of Genomic Duplications and Deletions / Graham R. Taylor, Carol A. Delaney -- Chapter 13. Multiplex Ligation-Dependent Probe Amplification (MLPA) and Methylation-Specific (MS)-MLPA: Multiplex Detection of DNA/mRNA Copy Number and Methylation Changes / Eline M. Sepers, Jan P. Schouten -- Chapter 14. Molecular Techniques for DNA Methylation Studies / Jörg Tost, Ivo G. Gut -- Chapter 15. High-Resolution Melting Curve Analysis for Molecular Diagnostics / Jared S. Farrar, Gudrun H. Reed, Carl T. Wittwer -- Chapter 16. DNA Microarrays and Genetic Testing / Lars Dyrskjøt, Karina Dalsgaard-Sørensen, Marie Stampe-Ostenfeld, Karin Birkenkamp-Demtroder, Kasper Thorsen, Claus L. Andersen, Mogens Kruhøffer, Jens L. Jensen, Torben F. Ørntoft -- Chapter 17. Arrayed Primer Extension Microarrays for Molecular Diagnostics / Neeme Tonisson, Eneli Oitmaa, Kaarel Krjutskov, Janne Pullat, Ilona Lind, Merike Leego, Ants Kurg, Andres Metspalu -- Chapter 18. Application of Proteomics to Disease Diagnostics / Samir Hanash, Ji Qiu, Vitor Faca -- Chapter 19. RNA-Based Variant Detection: The Protein Truncation Test / Johan T. den Dunnen -- Chapter 20. Protein Diagnostics by Proximity Ligation: Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses / Karl-Johan Leuchowius, Ola Söderberg, Masood Kamali-Moghaddam, Malin Jarvius, Irene Weibrecht, Katerina Pardali, Ulf Landegren -- Chapter 21. Mass Spectrometry and its Applications to Functional Proteomics / Thomas Köcher, Giulio Superti-Furga -- Chapter 22. Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and Clinical Care / Minoli Perera, Federico Innocenti -- Chapter 23. Nutrigenomics: Integrating Genomic Approaches into Nutrition Research / Lynette R. Ferguson, Martin Philpott, Matthew P.G. Barnett -- Chapter 24. Novel Next-Generation DNA Sequencing Techniques for Ultra High-Throughput Applications in Bio-Medicine / Wilhelm J. Ansorge -- Chapter 25. Locus-Specific and National/Ethnic Mutation Databases: Emerging Tools for Molecular Diagnostics / George P. Patrinos -- Chapter 26. Molecular Diagnostic Applications in Forensic Science / Bruce Budowle, John V. Planz, Rowan Campbell, Arthur J. Eisenberg -- Chapter 27. Mass Disaster Victim Identification Assisted by DNA Typing / Daniel Corach -- Chapter 28. Detection of Highly Pathogenic Viral Agents: Implications for Therapeutics, Vaccines and Biodefense / Kylene Kehn-Hall, Sina Bavari -- Chapter 29. Identification of Genetically Modified Organisms / Farid E. Ahmed -- Chapter 30. Molecular Diagnostics and Comparative Genomics in Clinical Microbiology / Alex van Belkum -- Chapter 31. Genetic Monitoring of Laboratory Rodents / Jean-Louis Guénet, Fernando J. Benavides -- Chapter 32. Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified Cells / Stephanie Laufs, Luisa Schubert, Patrick Maier, W. Jens Zeller, Stefan Fruehauf -- Chapter 33. Preimplantation Genetic Diagnosis / Martine de Rycke, Karen Sermon -- Chapter 34. Automated DNA Hybridization and Detection / Bert Gold -- Chapter 35. The Use of Microelectronic-Based Techniques in Molecular Diagnostic Assays / Piotr Grodzinski, Michael Ward, Robin Liu, Kathryn Scott, Saul Surrey, Paolo Fortina -- Chapter 36. Human Gene Patents and Genetic Testing / Timothy Caulfield, Yann Joly -- Chapter 37. Genetic Counseling and Ethics in Molecular Diagnostics / Mary Petrou -- Chapter 38. Genetic Testing and Psychology / Andrea Farkas Patenaude -- Chapter 39. General Considerations Concerning Safety in Biomedical Research Laboratories / William E. Grizzle, Walter C. Bell, Jerry Fredenburgh -- Chapter 40. Quality Management in the Laboratory / David Burnett.
  • The mouse as a developmental model / Paul T. Sharpe -- Culture of postimplantation mouse embryos / Paul Martin and David L. Cockroft -- Organ culture in the analysis of tissue interactions / Irma Thesleff and Carin Sahlberg -- Treatment of mice with retinoids in vivo and in vitro / Gillian M. Morriss-Kay -- Analysis of skeletal ontogenesis through differential staining of bone and cartilage / Michael J. Depew -- Cell grafting and labeling in postimplantation mouse embryos / Gabriel A. Quinlan ... [et al.] -- Production of transgenic rodents by the microinjection of cloned DNA into fertilized one-celled eggs / David Murphy -- Cre recombinase mediated alterations of the mouse genome using embryonic stem cells / Anna-Katerina Hadjantonakis, Melinda Pirity, and András Nagy -- Gene trapping in mouse embryonic stem cells / Jane Brennan and William C. Skarnes -- Application of lacZ transgenic mice to cell lineage studies / Catherine M. Watson ... [et al.] -- Transgenic RNA interference to investigate gene function in the mouse / Tilo Kunath -- Mouse primordial germ cells : isolation and in vitro culture / Patricia A. Labosky and Brigid L.M. Hogan -- Gene transfer to the rodent embryo by retroviral vectors / Marla B. Luskin -- The avian embryo : an overview / Ivor Mason -- Chick embryos : incubation and isolation / Ivor Mason -- New culture / Amata Hornbruch -- EC culture : a method to culture early chick embryos / Andrea Streit -- Grafting Henson's node / Claudio D. Stern -- Microsurgical manipulation of the notochord / Lúcia E. Alvares ... [et al.] -- Transplantation of avian neural tissue / Sarah Guthrie -- Grafting of apical ridge and polarizing region / Cheryl Tickle -- Tissue recombinations in collagen gels / Marysia Placzek -- Quail-chick chimeras / Marie-Aimée Teillet, Catherine Ziller, and Nicole M. Le Douarin -- Using fluorescent dyes for fate mapping, lineage analysis, and axon tracing in the chick embryo / Jonathan D.W. Clarke -- Gene transfer in avian embryos using replication-competent retroviruses / Cairine Logan and Philippa Francis-West -- Electroporation in avian embryos / Jun-ichi Funahashi and Harukazu Nakamura -- An overview of Xenopus development / Michael Jones and James C. Smith -- Mesoderm induction assays / C. Michael Jones and James C. Smith -- Experimental embryological methods for analysis of neural induction in the amphibian / Ray Keller, Ann Poznanski, and Tamira Elul -- A method for generating transgenic frog embryos / Shoko Ishibashi, Kristin L. Kroll, and Enrique Amaya -- Axolotl/newt / Malcolm Maden -- The zebrafish : an overview of its early development / Nigel Holder and Qiling Xu -- Small-scale marker-based screening for mutations in zebrafish development / Peter D. Currie, Thomas F. Schilling, and Philip W. ingham -- Microinjection and cell transplantation in zebrafish embryos / Qiling Xu, Derek Stemple, and Katherine Joubin -- Recent advances in meganuclease- and transposon-mediated transgenesis of medaka and zebrafish / Clemens Grabher and Joachim Wittbrodt -- Retinoids in nonmammalian embryos / Malcolm Maden -- Protochordates / Peter W.H. Holland and Hiroshi Wada -- Subtractive hybridization and construction of cDNA libraries / Bruce Blumberg and Juan Carlos Izpisúa Belmonte -- Differential display of eukaryotic mRNA / Antonio Tugores and Juan Carlos Izpisúa Belmonte -- Using DNA microarrays / Clare Pritchard, Peter Underhill, and Andy Greenfield -- Profiling gene transcription in the developing embryo : microarray analysis on gene chips / David Chambers and Andrew Lumsden -- RT-PCR on embryos using degenerate oligonucleotide primers / Anthony Graham -- Single-cell RT-PCR cDNA subtraction / Ebrahim Sakhinia ... [et al.] -- In-situ hybridization of rdioactive riboprobes to RNA in tissue sections / Radma Mahmood and Ivor Mason -- In-situ hybridization and immunohistochemistry in whole embryos / Carol Irving -- Wholemount in situ hybridization to Xenopus embryos / C. Michael Jones and James C. Smith -- Wholemount in situ hybridization to Amphioxus embryos / Peter W.H. Holland -- In-situ hybridization to sections (nonradioactive) / Maria Rex and Paul J. Scotting -- Immunohistochemistry using polyester wax / Andrew Kent -- Immunohistochemistry on whole embryos / Ivor Mason -- Whole embryo assays for programmed cell death / Anthony Graham -- Protein techniques : immunoprecipitation, in vitro kinase assays, and western blotting / Clive Dickson -- Microscopy and photmicrography techniques / Richard J.T. Wingate.
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  • pt. B, 2005 ScienceDirect
  • ch. 1. Introduction -- ch. 2. Absorption of UV-visible light -- ch. 3. Characteristics of fluorescence emission -- ch. 4. Effects of intermolecular photophysical processes on fluorescence emission -- ch. 5. Fluorescence polarization. Emission anisotropy -- ch. 6. Principles of steady-state and time-resolved fluorometric techniques -- ch. 7. Effect of polarity on fluorescence emission. Polarity probes -- ch. 8. Microviscosity, fluidity, molecular mobility. Estimation by means of fluorescent probes -- ch. 9. Resonance energy transfer and its applications -- ch. 10. Fluorescent molecular sensors of ions and molecules -- ch. 11. Advanced techniques in fluorescence spectroscopy.
  • Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
  • Molecular genetic testing in the genomic era / Charles J. Sailey and Ferrin C. Wheeler -- Array comparative genomic hybridization in cytogenetics and molecular genetics / S. Hussain Askree and Madhuri R. Hegde -- Pharmacogenomics : tailoring treatment based on genotype / Alan H.B. Wu -- Somatic alterations and targeted therapy / Allison M. Cushman-Vokoun -- Genome-wide association studies in disease risk calculation : the role of bioinformatics in patient care / Todd L. Edwards, Digna R. Velez Edwards, and Marylyn DeRiggi Ritchie -- Presymptomatic genetic testing : shifting the emphasis from reaction to prevention / Irene H. Hung and John C. Carey -- Prenatal testing : screening, diagnosis, and preimplantation genetic diagnosis / Eugene Pergament -- Newborn screening for metabolic disorders / Marzia Pasquali and Nicola Longo -- The role of genetic counseling in everyday medical practice / Kimberly J. Hart, Erin E. Baldwin, and D. Hunter Best -- Direct-to-consumer genetic testing / Caroline F. Wright and Daniel G. MacArthur.
  • Undoubtedly, Drosophila melanogaster, fruit fly, has proven to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on: how does a multi-cellular organism develop from a single-celled embryo? The discovery of the genes responsible for pattern formation has helped refine this question. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, axial patterning, growth regulation in Drosophila eye, and more.
  • Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
  • Part I. Introduction -- Ch. 1. Biology of heptocellular carcinoma: past, present and beyond -- Ch. 2. Overview of cholangiocarcinoma and evidence for a primary liver carcinoma spectrum -- Part II. Liver cancer development and pathogenesis -- Ch. 3. Pathology of hepatocellular carcinoma -- Part III. Genetics and epidemiology of liver cancer -- Ch. 4. Epidemiology of heptocellular carcinoma -- Ch. 5. Genetics and epidemiology of cholangiocarcinoma -- Part IV. Molecular basis of cancer susceptibility -- Ch. 6. Signaling pathways in viral related pre-neoplastic liver disease and heptocellular carcinoma -- Ch. 7. Epigenetic effects of persistent Hepatitis C virus infection and hepatocellular carcinoma -- Ch. 8. DNA methylation status in chronic liver disease and hepatocellular carcinoma -- Part V. Animal modes -- Ch. 9. Transgenic and knockout mouse models of liver cancer -- Ch. 10. Mosaic cancer mouse models and functional oncogenomics in hepatocellular carcinoma -- Ch. 11. The zebrafish model for liver carcinogenesis -- Part Vi. Global gene expression profiling of human liver cancer -- Ch. 12. Integrative and functional genomics of HCC -- Ch. 13. Molecular signatures of heptocellular carcinoma metastasis -- Ch. 14. Gene mutations and transcriptomic profiles associated to specific subtypes of hepatocellular tumors -- Part VII. Cancer stem cells -- Ch. 15. Cancer stem cells and liver cancer -- Ch. 16. Heterogeneity of liver cancer stem cells -- Ch. 17. Cancer stem cells in liver carcinoma -- Part VIII. Liver cancer genetics in the clinic -- Ch. 18. Moleuclar signaling in hepatocellular carcinoma -- Ch. 19. Molecular events on metastasis of hepatocellular carcinoma -- Ch. 20. Molecular pathogenesis of hepatocellular carcinoma -- Subject Index.
  • Genomic Alterations in Sporadic Pancreatic Cancer / Marco Dal Molin, Anirban Maitra -- Molecular Pathology of Pancreatic Cancer Precursor Lesions / Lodewijk A. A. Brosens, G. Johan Offerhaus -- Genetic Epidemiology and Pancreatic Cancer / Li Jiao, Donghui Li -- Translational Implications of Molecular Genetics for Early Diagnosis of Pancreatic Cancer / Michael A. Hollingsworth -- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer / Helen Court, Mark R. Philips, Dafna Bar-Sagi -- Molecular Targeted Therapies in Pancreatic Cancer / Edward Kim, Ethan V. Abel, Arunima Ghosh -- Mouse Models of Pancreatic Ductal Adenocarcinoma / Filip Bednar, Marina Pasca di Magliano -- The Genetics of Pancreatic Cancer Progression / Christine A. Iacobuzio-Donahue, -- Epigenetic Alterations in Pancreatic Cancer / Michael Ayars, Michael Goggins -- Innovative Technologies in the Molecular Characterization of Pancreatic Cancer / Iris H. Wei, Chandan Kumar-Sinha.
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    Beginnings : the molecular pathology of hemoglobin / David Weatherall -- Molecular cytogenetics / Debra M. Lillington, Silvana Debernardi & Bryan D. Young -- Stem cells / Eyal C. Attar & David T. Scadden -- The genetics of acute myeloid leukemias / D. Gary Gilliland -- Secondary myelodysplasia/acute myelogenous leukemia / D. Gary Gilliland & John G. Gribben -- Detection of minimal residual disease in hematological malignancies / Drew Provan & John G. Gribben -- Chronic myeloid leukaemia / Brian J. Druker -- Myelodysplastic syndromes / Jaqueline Boultwood & James S. Wainscott -- Myeloproliferative disorders / Anthony J. Bench, George S. Vassiliou, Brian J. P. Huntly & Anthony R. Green -- Lymphoid neoplpasms / Anthony G. Letai & John G. Gribben -- The molecular biology of multiple myeloma / P. Leif Bergsagel -- The molecular basis of anaemia / Lucio Luzzatto & Anastasios Karadimitris -- The molecular basis of iron metabolism / Nancy C. Andrews -- Hemoglobinopathies due to structural mutations / Ronald L. Nagel -- Haemoglobinopathies due to structural mutations / Ronald L. Nagel -- Molecular coagulation and thrombophilia / Björn Dahlbäck & Andreas Hillarp -- The molecular basis of hemophilia / Paul L. F. Giangrande -- The molecular basis of von Willebrand disease / Luciano Baronciani & Pier Mannuccio Mannucci -- Platelet disorders / Katharine A. Downes & Keith R. McCrae -- The molecular basis of blood cell alloantigens / Willem H. Ouwehand & Cristina Navarrete -- Functions of blood group antigens / John R. Pawloski & Marilyn J. Telen -- Autoimmune hematological disorders / Drew Provan, James B. Bussel & Adrian C. Newland -- Hematopoietic growth factors / Graham Molineux -- Molecular therapeutics in hematology / A. Keith Stewart & Jeffrey A. Medin -- Gene expression profiling in the study of lymphoid malignancies / Ulf Klein & Riccardo Dalla-Favera.
  • Molecular imaging 2008
    II Springer
    With the increasing interest in the experimental and clinical application of molecular imaging many institutions create research groups or interdisciplinary centers focussing on the complex development process of this new methodology. The aim for this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results.
  • This searchable database is a collection of in vivo molecular imaging agents developed for positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultrasound (US), computed tomography (CT), and optical imaging. MICAD, a key component of the "Molecular Libraries and Imaging" program of the NIH Roadmap, is being developed by NCBI, the National Center for Biotechnology Information".
  • The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing significantly. The process of molecular imaging includes key biotarget identification, design of specific molecular imaging probes, and their preclinical evaluation, e.g., in vivo using small animal studies. A multitude of such innovative molecular imaging probes have already entered clinical diagnostics in oncology. There is no doubt that in future the emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation that will optimize diagnostic processes.This handbook addresses all aspects of molecular imaging in oncology, ranging from basic research to clinical applications in the era of evidence-based medicine. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
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    Chapter 1. Molecular imaging -- Chapter 2. Basic cell & molecular biology -- Chapter 3. Ovreview of imaging modalities -- Chapter. 4. Molecular imaging strategies -- Chapter 5. Assays -- Chapter 6. Nanoparticle imaging -- Chapter 7. Clinical applications -- Chapter 8. Molecular imaging examples -- Chapter 10. Frequently asked questions -- Chapter 11. Useful tables -- Chapter 12. Probe structures table.
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    "Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilize. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered here"--Provided by publisher.
  • Part I: Molecular Imaging Theory and System -- Introduction -- Molecular Optical Simulation Environment -- Diffuse Optical Tomography -- Fluorescence Molecular Tomography -- Bioluminescence Tomography -- Positron Emission Tomography -- Radioisotope Labeled Molecular Imaging in SPECT -- MRI Facility-Based Molecular Imaging -- Other Molecular Imaging Technology -- Optical Multi-Modality Molecular Imaging -- Medical Image Processing and Analysis -- Part II: Molecular Probes -- Opportunities and Challenges of Radiolabeled Molecular Probes -- Oligonucleotide Probes -- Quantum Dots for Biological Imaging -- RGD-Based Molecular Probes for Integrin v3 Imaging -- Part III: Applications of Molecular Imaging -- Basics of Molecular Biology -- Molecular Imaging Techniques in Clinical Practice of Tumors -- Using Molecular Imaging Techniques to Study Protein-Protein Interactions -- Application of Molecular Imaging in Transgenic Animals -- Molecular Imaging Methods in Diabetes-Related Studies.
  • Part 1. Introduction to Glyco-Experiences -- Serendipity in Scientific Discoveries: Some Examples in Glycosciences / Yuan-Chuan Lee -- My 30-Year Devotion to the N-Linked Oligosaccharide Structures / Noriko Takahashi -- Part 2. Blood Group ABH/Le-related Antigens -- Human Blood Group ABH/Ii, Lea,b,x,y, and Sialyl Lea,x Glycotopes; Internal Structures; and Immunochemical Roles of Human Ovarian Cyst Glycoproteins / Albert M. Wu -- Lewis Glyco-Epitopes: Structure, Biosynthesis, and Functions / Hui-Li Chen -- A Unique Endo-β-Galactosidase that Cleaves Both Blood Group A and B Glycotopes / Su-Chen Li, Kimberly M. Anderson and Yu-Teh Li -- Part 3. Lectins -- Recognition Roles of Mammalian Structural Units and Polyvalency in Lectin-Glycan Interactions / Albert M. Wu, Jia-Haw Liu, Tanuja Singh and Zhangung Yang -- Adhesion/Growth-Regulatory Galectins: Insights into Their Ligand Selectivity Using Natural Glycoproteins and Glycotopes / Albert M. Wu, Tanuja Singh, Jia-Hau Liu, Sabine André and Martin Lensch, et al. -- Glycotope Structures and Intramolecular Affinity Factors of Plant Lectins for Tn/T Antigens / Pierre Rougé, Willy J. Peumans, Els J. M. Van Damme, Annick Barre and Tanuja Singh, et al. -- The Five Bacterial Lectins (PA-IL, PA-IIL, RSL, RS-IIL, and CV-IIL): Interactions with Diverse Animal Cells and Glycoproteins / Nechama Gilboa-Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Batya Lerrer and Anne Imberty, et al. -- On the Differential Sialic Acid Specificity of Lectins from Different Parts of Saraca indica / Bishnu P. Chatterjee and Mainak Majumder -- Regulation of Lectin Production by the Human Pathogens Pseudomonas aeruginosa and Chromobacterium violaceum: Effects of Choline, Trehalose, and Ethanol / Nachman C. Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Itschak Axelrad and Nechama Gilboa-Garber -- Non-carbohydrate-Mediated Interaction of Lectins with Plant Proteins / Jared Q. Gerlach, Michelle Kilcoyne, Seron Eaton, Veer Bhavanandan and Lokesh Joshi -- Novel Concepts About the Role of Lectins in the Plant Cell / Els J. M. Van Dammes, Elke Fouquaert, Nausicaä Lannoo, Gianni Vandenborre and Dieter Schouppe, et al. -- Part 4. Structures and Functions of Glycolipids -- Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization / Sandro Sonnino, Vanna Chigorno, Massimo Aureli, Anie Priscilla Masilamani and Manuela Valsecchi, et al. -- 9-O-Acetyl GD3 in Lymphoid and Erythroid Cells / Kankana Mukherjee, Suchandra Chowdhury, Susmita Mondal, Chandan Mandal and Sarmila Chandra, et al. -- GM3 Upregulation of Matrix Metalloproteinase-9 Possibly Through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A Pathways in Mouse Melanoma B16 Cells / Pu Wang, Xiaodong Wang, Peixing Wu, Jinghai Zhang and Toshinori Sato, et al. -- Pathological Roles of Ganglioside Mimicry in Guillain-Barré Syndrome and Related Neuropathies / Robert K. Yu, Toshio Ariga, Seigo Usuki and Ken-ichi Kaida -- Structure and Function of Glycolipids in Thermophilic Bacteria / Feng-Ling Yang, Yu-Liang Yang and Shih-Hsiung Wu -- Lipooligosaccharides of Neisseria Species: Similarity Between N. polysaccharea and N. meningitidis LOSs / Chao-Ming Tsai -- Part 5. Structures and Functions of Complex Carbohydrates -- Roles for N- and O-Glycans in Early Mouse Development / Suzannah A. Williams and Pamela Stanley -- Glycobiology in the Field of Gerontology (Glycogerontology) / Akira Kobata -- Galectins in Regulation of Apoptosis / Fu-Tong Liu, Ri-Yao Yang, Jun Saegusa, Huan-Yuan Chen and Daniel K. Hsu -- Avian and Human Influenza Virus Receptors and Their Distribution / Yasuo Suzuki -- Importance of a Factor VIIIc-Like Glycoprotein Expressed in Capillary Endothelial Cells (eFactor VIIIc) in Angiogenesis / Dipak K. Banerjee, Caroline M. Oliveira, José J. Tavárez, Viswa N. Katiyar and Subiman Saha, et al. -- Mucin O-Glycan Branching Enzymes: Structure, Function, and Gene Regulation / Pi-Wan Cheng and Prakash Radhakrishnan -- Studying Carbohydrate Self-Recognition in Marine Sponges Using Synthetic Aggregation Factor Epitopes / Johannis P. Kamerling and Adriana Carvalho de Souza -- Docking of Chitin Oligomers and Nod Factors on Lectin Domains of the LysM-RLK Receptors in the Medicago-Rhizobium Symbiosis / Pierre Rougé, Wim Nerinckx, Clare Gough, Jean-Jacques Bono and Annick Barre -- Part 6. Glycoimmunology -- O-Acetylated Sialic Acids and Their Role in Immune Defense / Roland Schauer, G. Vinayaga Srinivasan, Dirk Wipfler, Bernhard Kniep and Reinhard Schwartz-Albiez -- Sialylated and Sulfated Carbohydrate Ligands for Selectins and Siglecs: Involvement in Traffic and Homing of Human Memory T and B Lymphocytes / Reiji Kannagi, Katsuyuki Ohmori, Guo-Yun Chen, Keiko Miyazaki and Mineko Izawa, et al. -- Diversity of Natural Anti-α-Galactosyl Antibodies in Human Serum / Elwira Lisowska and Maria Duk -- Significance of Serum Glycoprotein Profiles in Spontaneous Tolerance After Liver Allograft Transplantation / Pei-Weng Wang and Tai-Long Pan -- Part 7. Glycobiology of Cancer -- Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands / Konstantinos Konstantopoulos and Susan N. Thomas -- Regulation of Glycosyltransferase Genes in Apoptotic Breast Cancer Cells Induced by l-PPMP and Cisplatin / Rui Ma, Elizabeth A. Hopp, N. Matthew Decker, Audrey Loucks and James R. Johnson, et al. -- Aberrant Glycosphingolipid Expression and Membrane Organization in Tumor Cells: Consequences on Tumor-Host Interactions / Alessandro Prinetti, Simona Prioni, Nicoletta Loberto, Massimo Aureli and Valentina Nocco, et al. -- Human KDN (Deaminated Neuraminic Acid) and Its Elevated Expression in Cancer Cells: Mechanism and Significance / Sadako Inoue, Ken Kitajima, Chihiro Sato and Shinji Go -- Polysialic Acid Bioengineering of Cancer and Neuronal Cells by N-Acyl Sialic Acid Precursor Treatment / Robert A. Pon, Wei Zou and Harold J. Jennings -- Part 8. Glyco Applications -- Synthesis of Hemagglutinin-Binding Trisaccharides / Cheng-Chung Wang, Suvarn S. Kulkarni, Medel Manuel L. Zulueta and Shang-Cheng Hung -- Fabrication and Applications of Glyconanomaterials / Po-Chiao Lin, Avijit Kumar Adak and Chun-Cheng Lin -- Glycan Arrays to Decipher the Specificity of Plant Lectins / Els J. M. Van Damme, David F. Smith, Richard Cummings and Willy J. Peumans -- Targeting C-Type Lectin for the Treatment of Flavivirus Infections / Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu and Shie-Liang Hsieh.
  • ch. 1. Introduction, p. 1-8 -- ch. 2. Fundamentals of Molecular Imprinting, p. 9-19 -- ch. 3. Experimental Methods (1 - Procedures of Molecular Imprinting, p. 21-45 -- ch. 4. Experimental Methods (2 - Evaluation of Imprinting Efficiency, p. 47-52 -- ch. 5. Spectroscopic Anatomy of Molecular Imprinting Reactions, p. 53-64 -- ch. 6. Flow Chart of a Typical Molecular Imprinting, p. 65-73 -- ch. 7. Applications of Molecularly Imprinted Polymers, p. 75-118 -- ch. 8. Recent Challenges and Progress, p. 119-139 -- ch. 9. Conclusions and Prospects, p. 141.
  • Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
  • Spermatogenesis and cycle of the seminiferous epithelium / Rex A. Hess and Luiz Renato de Franca -- Testicular development and spermatogenesis : harvesting the postgenomics bounty / Antoine D. Rolland, Bernard Jogou and Charles Pineau -- Estrogens and spermatogenesis / Chandrima Shaha -- Selenium, a key element in spermatogenesis and male fertility / Carla Boitani and Rossella Puglisi -- Extracellular matrix and its role in spermatogenesis / Michelle K.Y. Siu and C. Yan Cheng -- Inflammatory networks in the control of spermatogenesis : chronic inflammation in an immunologically privileged tissue? / Moira K. O'Bryan and Mark P. Hedger -- Transcription regulation in spermatogenesis / Wing-Yee Lui and C. Yan Cheng -- Proteases and their cognate inhibitors of the serine and metalloprotease -- Subclasses, in testicular physiology / Brigitte Le Magueresse-Battistoni -- Antioxidant systems and oxidative stress in the testes / R. John Aitken and Shaun D. Roman -- Nitric oxide and cyclic nucleotides : their roles in junction dynamics and spermatogenesis / Nikki P.Y. Lee and C. Yan Cheng -- The sertoli cell cytoskeleton / A. Wayne Vogl, Kuljeet S. Vaid and Julian A. Guttman -- Blood-testis barrier, junctional and transport proteins and spermatogenesis / Brian P. Setchell -- Cross-talk between tight and anchoring junctions : lesson from the testis / Helen H.N. Yan ... [et al.] -- The role of the leydig cell in spermatogenic function / Renshan Ge, Guorong Chen and Matthew P. Hardy.
  • Speakers at the Symposium / Hartmann, D. -- Hematopoietic stem cell aging and fate decision / Illing, A., Ju, Z. -- Alterations of systemic environment impair stem cell function during aging / Song, Z., Ju, Z. -- Novel insights into regulation of stem cell aging by aging of the niche and alterations in systemic factors / Geiger, H. -- Aging and hematopoietic malignancies / Gompf, A. -- Intestinal stem cell aging / Sperka, T., Rudolph, K.L. -- Molecular mechanisms of aging in muscle stem cells / Tümpel, S. -- Free radicals and stem cell aging / Guachalla, L.M. -- DNA damage, checkpoint responses, and cell cycle control in aging stem cells / Sperka, T., Nalapareddy, K., Rudolph, K.L.
  • Identification of the gene involved in 4q25-linked Axenfeld-Rieger syndrome, PITX2 / Elena V. Semina -- Winged helix/forkhead transcription factors and Rieger syndrome / Darryl Y. Nishimura and Ruth E. Swiderski -- Rieger syndrome and PAX6 deletion / Ruth Riise -- The molecular and biochemical basis of Axenfeld-Rieger syndrome / Brad A. Amendt -- Role of PITX2 in the pituitary gland / Hoonkyo Suh ... [et al.] -- Expression and function of PITX2 in chick heart looping / Xueyan Yu, Shusheng Wang, and YiPing Chen -- The multiple roles of PITX2 in heart development / James F. Martin -- The role of PITX2 in tooth development / Brad A. Amendt -- PITX genes and ocular development / Elena V. Semina -- An overview of Axenfeld-Rieger syndrome and the anterior segment developmental disorders / Brad A. Amendt.
  • Functional morphology of the gastrointestinal tract / L. Shen -- Vibrio cholerae interactions with the gastrointestinal tract: Lessons from animal studies / J.M. Ritchie and M.K. Waldor -- Interaction of Yersinia with the gut: Mechanisms of pathogenesis and immune evasion / P. Dube -- Molecular mechanisms of Salmonella virulence and host resistance / Y. Valdez, R.B.R. Ferreira and B.B. Finlay -- Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori / tW. Fischer, S. Prassl and R. Haas -- Listeria as an enteroinvasive gastrointestinal pathogen / S.B. Barbuddhe and T. Chakraborty -- Molecular mechanisms of Campylobacter infection / J.P.M. Putten ... [et al.] -- Shigella infection of intestinal epithelium and circumvention of the host innate defense system / H. Ashida ... [et al.].
  • The epidemiology of basal cell and squamous cell carcinoma / Hao Wang and Thomas L. Diepgen -- Histology of epithelial skin tumors / Jörg Reichrath and Kerstin Querings -- UV damage and DNA repair in basal cell and squamous cell carcinomas / Knuth Rass -- Papillomavirus infections and cancerogenesis of squamous cell and basal cell carcinomas / Guido Bens -- The immune system and nonmelanoma skin cancers / Elma D. Baron -- Cytogenetics of basal cell carcinoma and squamous cell carcinomas / Melanie A. Carless, Kevin J. Ashton and Lyn R. Griffiths -- The hedgehog signaling pathway and epithelial skin cancer / Julia Reifenberger -- p53 protein and nonmelanoma skin cancer / Vladislava O. Melnikova and Honnavara N. Ananthaswamy -- TGF-[beta] pathway and cancerogenesis of epithelial skin tumors / Miguel Quintanilla ... [et al.] -- PDGF pathways and growth of basal cell and squamous cell carcinomas / Jingwu Xie -- Apoptosis and cancerogenesis of basal cell and squamous cell carcinoma / Peter Erb ... [et al.] -- The role of telomerase for cancerogenesis of basal cell and squamous cell carcinomas / Eva-Maria Fabricius.
  • Theories of carcinogenesis -- Physioloigic correlates of malignancy -- Cell division and survival -- Cellular senescence -- Invasiveness -- DNA repair -- Epigenetic regulation of cancer-associated gene products -- Interaction of the groups of cancer-related gene products -- Structural growth control -- The organ preference of metastasis formation -- Angiogenesis -- Interactions with the immune system -- Endocrine dysregulation -- Dormancy and minimal residual disease -- Epithelial tumors -- Hematologic malignancies -- Mesenchymal tumors -- Neurologic tumors -- Tumors of serous cavities -- Embryonic tumors.
  • Clinical features of Fanconi anaemia / A. Malcolm, R. Taylor -- The genetic basis of Fanconi anemia / Grover C. Bagby, Jr. -- The FANCA gene and its products / Laura S. Haneline -- The FANCC gene and its products / Susan M. Gordon and Manuel Buchwald -- The FANC B, E, F and G genes and their products / Filippo Rosselli -- FANCD1/BRCA2 and FANCD2 / Gary M. Kupfer -- The FANC genome surveillance complex / Takayuki Yamashita -- Other proteins and their interactions with FA gene products / Tetsuya Otsuki and Johnson M. Liu -- Fanconi anaemia and oxidative stress: cellular and clinical phenotypes / Giovanni Pagano and Shamim I. Ahmad -- Therapy for Fanconi anemia / Madeleine Carreau -- Mutational analyses of Fanconi anemia genes in Japanese patients / Akira Tachibana.
  • Current and emerging approaches to studying invasion in apicomplexan parasites / Jeffrey Mital and Gary E. Ward -- Microneme proteins in apicomplexans / Vern B. Carruthers and Fiona M. Tomley -- Erythrocyte invasion by plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching / Manoj T. Duraisingh ... [et al.] -- Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of trypanosoma cruzi with host structures / Maria Jølia M. Alves and Walter Colli -- Calcium regulation and signaling in apicomplexan parasites / Kisaburo Nagamune ... [et al.] -- Trypanosoma cruzi: parasite and host cell signaling during the invasion process / Nobuko Yoshida and Mauro Cortez -- Host cell actin remodeling in response to cryptosporidium / Steven P. O'Hara ... [et al.] -- Host cell actin remodeling in response to trypanosoma cruzi: trypomastigote versus amastigote entry / Renato A. Mortara ... [et al.] -- Actin/myosin-based gliding motility in apicomplexan parasites / Kai Matuschewski and Herwig Schøler -- Roles of proteases during invasion and egress by plasmodium and toxoplasma / Timothy J. Dowse ... [et al.] -- Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by trypanosoma cruzi / Julio Scharfstein and Ana Paula C.A. Lima -- Biogenesis of and activities at the toxoplasma gondii parasitophorous vacuole membrane / Anthony P. Sinai. The role of host cell lysosomes in trypanosoma cruzi invasion / G. Adam Mott and Barbara A. Burleigh -- Leishmania invasion and phagosome biogenesis / Robert Lodge and Albert Descoteaux -- Plasmodium sporozoite passage across the sinusoidal cell layer / Ute Frevert ... [et al.] -- Transepithelial migration by toxoplasma / Antonio Barragan and Niclas Hitziger -- The microsporidian polar tube and its role in invasion / Frederic Delbac and Valerie Polonais -- Intestinal invasion by entamoeba histolytica / Shahram Solaymani-Mohammadi and William A. Petri, Jr.
  • Clinical assessment in the spondyloarthropathies / Ruth Wittoek and Herman Mielants -- Imaging in spondyloarthritis / Walter P. Maksymowych -- Spondyloarthritis, diffuse idiopathic skeletal hyperostosis (DISH), and chondrocalcinosis / Jácome Brugues Armas, Ana Rita Couto, and Bruno Filipe Bettencourt -- The enthesis organ concept and its relevance to the spondyloarthropathies / Michael Benjamin and Dennis McGonagle -- Synovial and mucosal immunopathology in spondyloarthritis / Bernard Vandooren, Paul P. Tak, and Dominique Baeten -- Bone loss in the spondyloarthropathies : role of osteoclast, RANKL, RANK, and OPG in the spondyloarthropathies / Allen P. Anandarajah and Edward M. Schwarz -- RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies / Andreas Leibbrandt and Josef M. Penninger -- Bone formation versus bone resorption in ankylosing spondylitis / Georg Schett -- Biomarkers in spondyloarthropathies / Chun-Hsiung Chen, David Tak Yan Yu, and Chung-Tei Chou -- Therapy of spondyloarthritides / Jürgen Braun -- Genomewide screens in ankylosing spondylitis / Matthew A. Brown -- Subtypes of HLA-B27 : history and implications in the pathogenesis of ankylosing spondylitis / John D. Reveille -- Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis / Andreas Ziegler ... [et al.] -- HLA-B27-bound peptide repertoires : their nature origin and pathogenetic relevance / José A. López de Castro.
  • Pt. 1. Experimental models of synaptogenesis -- Pt. 2. Roles of cell adhesion and secreted molecules in synaptic differentiation -- Pt. 3. Transport of synaptic proteins -- Pt. 4. Synaptic cytoskeleton and morphogenic signaling -- Pt. 5. Synaptic plasticity in learning and memory -- Pt. 6. Synaptogenesis and brain disorders.
  • Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors. This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.
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    Historical aspects of xeroderma pigmentosum and nucleotide excision repair / James E. Cleaver -- Clinical features of xeroderma pigmentosum / Ulrich R. Hengge and Steffen Emmert -- Xeroderma pigmentosum and skin cancer / Leela Daya-Grosjean -- XPA gene, its product and biological roles / Ulrike Camenisch and Hanspeter Nogeli -- XPB and XPD between transcription and DNA repair / Brian D. Beck, Dae-Sik Hah, and Suk-Hee Lee -- XPC: its product and biological roles / Kaoru Sugasawa -- The XPE gene of xeroderma pigmentosum : its product and biological roles / Drew Bennett and Toshiki Itoh -- XPF/ERCC4 and ERCC1 : their products and biological roles / Lisa D. McDaniel and Roger A. Schultz -- XPG: its products and biological roles / Orlando D. Schorer -- Xeroderma pigmentosum variant, XPV: its product and biological roles / Chikahide Masutani, Fumio Hanaoka, and Shamim I. Ahmad -- Other proteins interacting with XP proteins / Steven M. Shell and Yue Zou -- The nucleotide excision repair of DNA in human cells and its association with xeroderma pigmentosum / Alexei Gratchev -- Roles of oxidative stress in xeroderma pigmentosum / Masaharu Hayashi -- Xeroderma pigmentosum : its overlap with trichothiodystrophy, Cockayne syndrome, and other progeroid syndromes / W. Clark Lambert, Claude E. Gagna, and Muriel W. Lambert -- Population distribution of xeroderma pigmentosum / Abdul Manan Bhutto and Sandra H. Kirk -- Progress and prospects of xeroderma pigmentosum therapy / Alain Sarasin -- Animal models of xeroderma pigmentosum / Xue-Zhi Sun ... [et al.].
  • Sect. I. Molecular Biology -- Ch. 1. Parasite genomics -- Ch. 2. RNA processing in parasitic organisms: trans-splicing and RNA editing -- Ch. 3. Transcription -- Ch. 4. Post-transcriptional regulation -- Ch. 5. Antigenic variation in African trypanosomes and malaria -- Ch. 6. Genetic and genomic approaches to the analysis of leishmania virulence -- Sect. II. Biochemistry and Cell Biology: Protozoa -- Ch. 7. Energy metabolism -- Ch. 8. Amino acid and protein metabolism -- Ch. 9. Purine and pyrimidine transport and metabolism -- Ch. 10. Trypanosomatid surface and secreted carbohydrates -- Ch. 11. Intracellular signaling -- Ch. 12. Plastids, mitochondria, and hydrogenosomes -- Sect. III. Biochemistry and Cell Biology: Helminths -- Ch. 13. Helminth surfaces: structural, molecular and functional properties -- Ch. 14. Carbohydrate and energy metabolism in parasitic helminths -- Ch. 15. Neurotransmitters -- Sect. IV. Medical Applications -- Ch. 16. Drug resistance in parasites -- Ch. 17. Medical implications of molecular parasitology.
  • 2012 ClinicalKey
    Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances. Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicineThe only book in Molecular Medicine to reach its fourth edition Identifies current practice as well as future developmentsPresents extensive tables, well presented figures and resources for further understanding.
  • Molecular mimicry, microbial infection, and autoimmune disease : evolution of the concept / M.B.A. Oldstone -- The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination / K.W. Wucherpfennig -- A virus-induced molecular mimicry model of multiple sclerosis / J.K. Olson, A.M. Ercolini, and S.D. Miller -- Suppression of autoimmunity via microbial mimics of altered peptide ligands / L. Steinman, P.J. Utz, and W.H. Robinson -- Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry / M.B.A. Oldstone -- Trypanosoma cruzi-induced molecular mimicry and Chagas' disease / N. Gironès, H. Cuervo, and M. Fresno -- HTLV-1 induced molecular mimicry in neurological disease / S.M. Lee ... [et al.] -- Molecular mimicry : anti-DNA antibodies bind microbial and nonnucleic acid self-antigens / J.S. Rice ... [et al.] -- Chlamydia and antigenic mimicry / K. Bachmaier and J.M. Penninger.
  • "Preface Over the past few decades, molecular modeling (MM) has become an important tool in many academic institutions and industrial laboratories. While the role of MM in biological fields--especially in the design and development of novel drug molecules or formulations--is well established and acknowledged, its direct role in the design and development of performance chemicals and novel materials is still not well known. Questions such as, which new products have resulted from an MM-based approach? are still often asked. Although MM may be playing an important role in product development, quite often it becomes difficult to predict its direct impact because most of the time the problem being addressed involves a multidisciplinary approach. Further, the assumption that fundamental phenomena being modeled though MM will have a direct impact on the macroscopic and functional properties of a product make the situation more complicated. In most of the cases, MM actually works as an enabler toward novel product and material development (e.g., novel drug molecules in biological application) rather than directly coming up with new products and materials. This precisely is the reason that despite seeing value in MM tools, most engineers and practitioners are often focus on the question, how do I leverage these tools to design and develop novel materials or chemicals for the industry I am working with? Unfortunately, there is no simple answer to this question. Excellent books and very good research publications highlight the most intricate, fundamental, and theoretical details about MM techniques and tools"-- Provided by publisher.
  • Molecular modeling of proteins 2008
    Springer Protocols
    Molecular dynamics simulations / Erik R. Lindahl -- Monte Carlo simulations / David J. Earl and Michael W. Deem -- Hybrid quantum and classical methods for computing kinetic isotope effects of chemical reactions in solutions and in enzymes / Jiali Gao ... [et al.] -- Comparison of protein force fields for molecular dynamics simulations / Olgun Guvench and Alexander D. MacKerell, Jr. -- Normal modes and essential dynamics / Steven Hayward and Bert L. de Groot -- Calculation of absolute protein-ligand binding constants with the molecular dynamics free energy perturbation method / Hyung-June Woo -- Free energy calculations applied to membrane proteins / Christophe Chipot -- Molecular dynamics simulations of membrane proteins / Philip C. Biggin and Peter J. Bond -- Membrane-associated proteins and peptides / Marc F. Lensink -- Implicit membrane models for membrane protein simulation / Michael Feig -- Comparative modeling of proteins / Gerald H. Lushington -- Transmembrane protein models based on high-throughput molecular dynamics simulations with experimental constraints / Andrew J. Beevers and Andreas Kukol -- Nuclear magnetic resonance-based modeling and refinement of protein three-dimensional structures and their complexes / Gloria Fuentes, Aalt D.J. van Dijk, and Alexandre M.J.J. Bonvin -- Conformational changes in protein function / Haiguang Liu ... [et al.] -- Protein folding and unfolding by all-atom molecular dynamics simulations / Hongxin Lei and Yong Duan -- Modeling of protein misfolding in disease / Edyta B. Małolepsza -- Identifying putative drug targets and potential drug leads : starting points for virtual screening and docking / David S. Wishart -- Receptor flexibility for large-scale in silico ligand screens : chances and challenges / B. Fischer, H. Merlitz, and W. Wenzel -- Molecular docking / Garrett M. Morris and Marguerita Lim-Wilby.
  • Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as the "reward center" of the brain, where a number of chemical messengers work in concert to provide a net release of dopamine in the Nucleus Accumbens. In some genetically predisposed individuals, addiction occurs when the mechanisms of the mesolimbic system are disrupted by the use of various drugs of abuse. Since Alcoholics Anonymous was founded in 1935, it's 12 step program of spiritual and character development has helped countless alcoholics and drug addicts curb their self-destructive behaviors. However, the program was developed at a time when comparatively little was known about the function of the brain and it has never been studied scientifically. This is the first book to take a systematic look at the molecular neurobiology associated with each of the 12 steps and to review the significant body of addiction research literature that is pertinent to the program.
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  • Introduction to molecular neurosurgery / Ronald G. Wiley and Douglas A. Lappi -- Ribosome-inactivating proteins / Fiorenzo Stirpe -- Biochemical, physiological, and behavioral characterizations of the cholinergic basal forebrain lesion produced by 192 IgG-saporin / Jerene J. Waite -- Basal forebrain cholinergic lesion by 192 IgG-saporin: a tool to assess the consequences of cortical cholinergic dysfunction in Alzheimers disease / Reinhard Schliebs -- 192 IgG-saporin-induced partial cortical cholinergic deafferentation as a model for determining the interactions between brain aging and neurodevelopmental defects in the cortical cholinergic input system / Martin Sarter and John P. Bruno -- Exploring the role of acetylcholine in primate cognition using Me20.4 IgG-saporin / Rosalind M. Ridley and Harry F. Baker -- Cortical cholinergic deafferentation induces A-beta deposition: towards a physiologic animal model of Alzheimer's disease / Thomas G. Beach ... [et al.] -- Chemical dissection of brain glucoregulatory circuitry / Sue Ritter ... [et al.] -- Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin / Patrice G. Guyenet, Ruth L. Stornetta, and Ann M. Schreihofer -- Saporin conjugates and pain / Ronald G. Wiley and Douglas A. Lappi -- The use of saporin conjugates to dissect neurons responsible for sleep and wakefulness / Carlos Blanco-Centurion ... [et al.] -- Isolectin I-B4-mediated cytotoxic targeting of sensory neurons / Lucy Vulchanova and Christopher N. Honda -- B fragment of cholera toxin conjugated to saporin / Peter T. O'hara, Kanwarjit Kelley, and Luc Jasmin.
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    DNA repair and the maintenance of genomic stability in breast cancer / Jennifer E. Quinn, Richard D. Kennedy, and D. Paul Harkin -- Biologic and clinical significance of DNA gene methylation and epigenetic events in breast cancer / Manel Esteller and Esteban Ballestar -- DNA methylation in breast cancer as diagnostic markers and targets for cancer therapy / Sabine Maier ... [et al.] -- Pharmacogenetics, pharmacogenomics, and predicting response to therapy / Lajos Pusztai ... [et al.] -- Mammography and molecular imaging / Hernan I. Vargas, M. Perla Vargas, and Iraj Khalkhali -- Translation of molecular markers to clinical practice / Nadia Harbeck, Christoph Thomssen, and Ronald E. Kates -- Regulatory aspects and implications of molecular testing in the United States / Robert Pietrusko. Epidermal growth factor receptor and other growth factors and receptors / Joan Albanell and Jeffrey S. Ross -- Tumor-associated proteolytic factors: markers for tumor invasion and metastasis / Nadia Harbeck ... [et al.] -- Breast cancer and angiogenesis / Manfred Schmitt, Nadia Harbeck, and Jeffrey S. Ross -- Cell adhesion markers / Heinz Höfler and Birgit Luber -- Programmed cell death and breast cancer / Xiao-Ming Yin and Gerald P. Linette -- Oncogenes / Andre M. Oliveira and Jonathan A. Fletcher -- p53 and tumor suppressor genes in breast cancer / Andre M. Oliveira, Jeffrey S. Ross, and Jonathan A. Fletcher -- The ubiquitin-proteasome pathway and breast cancer / Robert Z. Orlowski -- Introduction and background / Gabriel N. Hortobagyi -- Molecular diagnostic techniques in breast cancer / Jeffrey S. Ross -- Clinical and molecular epidemiology of breast cancer / Abenaa Brewster and Melissa Bondy -- Predisposition for breast cancer / Marion Kiechle and Alfons Meindl -- Screening and early detection, serum and nipple aspirates, routine and molecular methods, including reverse transcriptase-polymerase chain reaction, and proteomics / Douglas P. Malinowski -- Genomic and molecular classification of breast cancer / Christos Sotiriou ... [et al.] -- Cytology: clinical sample procurement and on-slide technologies / W. Fraser Symmans -- Histopathology of breast cancer: correlation with molecular markers / W. Fraser Symmans -- Sentinel lymph node dissection and micrometastasis detection in bone marrow and lymph nodes / Volkmar Müller, Sabine Kasimir-Bauer, and Klaus Pantel -- Prognostic and predictive factors overview / Jeffrey S. Ross and Nadia Harbeck -- Breast cancer cytogenetics, chromosomal abnormalities, and comparative genomic hybridization / Mark Watson and Lynn Cawkwell -- DNA ploidy and S phase analysis in breast cancer / Jeffrey S. Ross ... [et al.] -- Cell proliferation markers and cell cycle regulators in breast cancer / Jeffrey S. Ross and Carlos Cordon-Cardo -- Targeted therapy for cancer: integrating diagnostics and therapeutics / Jeffrey S. Ross -- Hormone receptors and hormonal-based therapy for breast cancer / Jeffrey S. Ross and Gabriel N. Hortobagyi -- HER-2/neu gene and protein in breast cancer / Fatima Cardoso ... [et al.] --
  • Part I. Overview of Basic Cellular Biology -- 1. Normal molecular biology and definition of terms -- 2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins -- 3. Standard nomenclature -- introduction and brief overview -- Part II. Molecular Oncology Methodology -- 4. General principles of Oncology testing -- 5. Molecular methodologies -- 6. General principles of validating a molecular test -- Part III. Molecular testing in Solid Tumors -- 7. Lung and mediastinum -- 8. Breast -- 9. Head and neck (salivary glands) -- 10. Thyroid and parathyroid (endocrine) -- 11. Gastrointestinal and Pancreatobiliary -- 12. Soft tissue -- 13. Genitourinary system -- 14. Central Nervous System -- 15. Skin and adnexa -- 16. Common Hereditary Cancer Syndromes -- Part IV. The future is here -- 17. Application of next generation sequencing -- Part V. Quality Assurance and Regulatory affairs -- 18. Quality Assurance -- pre-analytic, analytic and post-analytic -- 19. Regulatory affairs (including accreditation) -- 20. Coding and re-imbursement.
  • Molecular pain 2007
    Genes, neurons and neurotransmission -- Glutamate, excitatory transmission and pain -- Neuropeptides, ATP, retrograde messengers and opioids -- Inhibitory transmission and plasticity -- Postsynaptic signaling and gene regulation -- Peripheral nociceptor, amygdala and fear -- Spinal plasticity, reorganization and chronic pain -- Cortical plasticity, reorganization and amputation -- Endogenous analgesia and other form of analgesia -- Models for studying pain and searching for pain killers.
  • Genetic analysis of bacterial pathogenesis -- Genetic exchance in bacteria and the modular stucture of mobile DNA elements -- Genomics and the use of genomic tools to study pathogenic bacteria -- Pathogenicity islands and bacterial virulence -- Capsules -- Bacterial cell walls -- Mechanisms of bacterial adhesion and consequences of attachment -- Bacterial invasion into non-phagocytic cells -- Bacterial protein secretion mechanisms -- Toxins as host cell modulators -- Quorum sensing: coordinating group behavior through intercellular signals -- The role of sigma factors in regulating bacterial stress responses and pathogenesis -- Two-component regulatory systems -- Oxidative stress systems in bacteria: four model organisms -- Bacterial biowarfare agents.
  • Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
  • Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
  • Basics of molecular biology -- Molecular pathology methods -- Genetic counseling -- Pedigree analysis and risk assessment -- Bayesian analysis -- Developmental disabilities -- Neuromuscular diseases -- Molecular genetic testing for metabolic disorders -- Fibroblast growth factor receptor-related skeletal disorders -- Cystic fibrosis -- Deafness -- Coagulation disorders -- Hematologic disorders : hemochromatosis, hemoglobinopathies, and Rh incompatibility -- Cardiovascular disease -- Neurodegenerative disorders -- Skin and connective tissue disorders -- Inherited breast cancer -- Familial adenomatous polyposis and Turcot and Peutz-Jeghers syndromes -- Hereditary nonpolyposis colorectal cancer -- Multiple endocrine neoplasia syndromes -- The neurofibromatoses -- TP53 mutation and Li-Fraumeni syndrome -- von Hippel-Lindau disease -- Breast cancer -- Urothelial carcinoma -- Sarcomas -- Gliomas -- Molecular detection of occult tumor cells -- Microarray studies (Beyond histology) -- Acute myeloid leukemia -- Acute lymphoblastic leukemia -- B-cell lymphomas -- T-cell lymphomas -- Lymphoproliferations of immunodeficiency -- Myeloproliferative disorders and myelodysplastic syndromes -- Human immunodeficiency virus type 1 -- Hepatitis B and C viruses -- Viral infections in transplant patients -- Viral infections of the central nervous system -- Sexually transmitted diseases -- Respiratory pathogens -- Bacterial pathogens -- Mycobacterial infections -- Forensic DNA typing -- Parentage and relationship testing -- Assessment of chimerism in the setting of allogenic hematopoietic cell transplantation -- Specimen identification through DNA analysis -- Molecular HLA typing -- Molecular pathology laboratory management -- From research to clinical practice.
  • Molecular oncogenesis -- Systematic autoimmune diseases -- MicroRNAs in endocrine diseases -- Clinical detection and treatment of thyroid diseases -- Autoimmune thyroid diseases -- Benign nodular thyroid disease -- Fine needle aspiration: present and future -- Well-differentiated papillary thyroid carcinoma -- Well-differentiated thyroid follicular carcinoma -- Poorly differentiated and undifferentiated thyroid carcinomas -- Medullary thyroid carcinoma -- Unusual thyroid tumors -- Hematopoietic tumors of the thyroid -- Clinical detection and treatment of parathyroid diseases -- Nonneoplastic parathyroid diseases -- Neoplastic parathyroid diseases -- Clinical detection and treatment of benign and malignant pituitary diseases -- Nonneoplastic and neoplastic pituitary diseases -- Clinical detection and treatment of adrenal disease -- Benign and malignant pheochromocytomas and paragangliomas -- Benign and malignant diseases of the adrenal cortex -- Clinical detection and treatment of pancreatic neuroendocrine tumors -- Pancreatic endocrine neoplasms -- Gastrointestinal neuroendocrine tumors -- Head and neck neuroendocrine tumors -- Merkel cell carcinoma -- Neuroendocrine lung tumors.
  • Section I. Molecular Pathology of Hematolymphoid Neoplasms: General Principles -- Molecular Oncogenesis / Aniruddha J. Deshpande, Christian Buske, Leticia Quintanilla-Martinez, and Falko Fend -- Genetic Predispositions for Hematologic and Lymphoid Disorders / Frederick G. Behm -- Prognostic Markers / David Bahler -- Cancer Stem Cells: Potential Targets for Molecular Medicine / Isabel G. Newton and Catriona H.M. Jamieson -- Gene Therapy for Leukemia and Lymphoma / Xiaopei Huang and Yiping Yang -- Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression) / Richard J.Q. McNally -- Viral Oncogenesis / Alexander A. Benders and Margaret L. Gulley -- Section II. Specific Techniques and Their Applications in Molecular Hematopathology -- Techniques to Determine Clonality in Hematolymphoid Malignancies / Daniel E. Sabath -- Techniques to Detect Defining Chromosomal Translocations/Abnormalities / Jennifer J.D. Morrissette, Karen Weck, and Cherie H. Dunphy -- Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease / Marie E. Beckner and Jeffrey A. Kant -- Detection of Resistance to Therapy in Hematolymphoid Neoplasms / Karen Weck -- Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting / Jessica K. Booker -- Gene Expression Profiling / Cherie H. Dunphy -- Proteomics of Human Malignant Lymphoma / Megan S. Lim, Rodney R. Miles, and Kojo S.J. Elenitoba-Johnson -- Mouse Models of Hematolymphoid Malignancies / Krista M.D. La Perle and Suzana S. Couto -- Section III. Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes -- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Patricia Aoun -- Marginal Zone B-Cell Lymphoma / Lynne V. Abruzzo and Rachel L. Sargent -- Lymphoplasmacytic Lymphoma / Pei Lin -- Molecular Pathology of Plasma Cell Neoplasms / James R. Cook -- The Roles of Molecular Techniques in the Diagnosis and Management of Follicular Lymphoma / W. Richard Burack -- Mantle Cell Lymphoma / Kai Fu and Qinglong Hu -- Diffuse Large B-Cell Lymphomas / Cherie H. Dunphy -- The Molecular Pathology of Burkitt Lymphoma / Claudio Mosse and Karen Weck -- Precursor B-Cell Acute Lymphoblastic Leukemia / Julie M. Gastier-Foster -- Molecular Genetics of Mature T/NK Neoplasms / John P. Greer, Utpal P. Davé, Nishitha Reddy, Christine M. Lovly, and Claudio A. Mosse -- Precursor T-Cell Neoplasms / Kim De Keersmaecker and Adolfo Ferrando -- Classical Hodgkin Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma / Michele Roullet and Adam Bagg -- Posttransplant Lymphoproliferative Disorder / Margaret L. Gulley -- AIDS-Related Lymphomas / Amy Chadburn and Ethel Cesarman -- Chronic Myelogenous Leukemia / Dan Jones -- Molecular Pathogenesis of Nonchronic Myeloid Leukemia Myeloproliferative Neoplasms / Mike Perez and Chung-Che (Jeff) Chang -- Molecular Pathology of Myelodysplastic/Myeloproliferative Neoplasms, Myeloid, and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, and FGFR1, and Mastocytosis / Robert P. Hasserjian -- Molecular Pathogenesis of Myelodysplastic Syndromes / Jesalyn J. Taylor and Chung-Che "Jeff" Chang -- Acute Myeloid Leukemias with Recurrent Cytogenetic Abnormalities / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemias with Normal Cytogenetics / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia / Sergej N. Konoplev and Carlos E. Bueso-Ramos -- Molecular Pathology of Hemoglobin and Erythrocyte Membrane Disorders / Murat O. Arcasoy and Patrick G. Gallagher -- White Blood Cell and Immunodeficiency Disorders / John F. Bastian and Michelle Hernandez -- Molecular Basis of Disorders of Hemostasis and Thrombosis / Alice Ma -- Sarcoidosis: Are There Sarcoidosis Genes? / Helmut H. Popper -- Castleman's Disease / Richard Flavin, Cara M. Martin, Orla Sheils, and John James O'Leary -- Molecular Pathology of Histiocytic Disorders / Mihaela Onciu -- Reactive Lymphadenopathies: Molecular Analysis / Dennis P. O'Malley -- Molecular Pathology of Infectious Lymphadenitides / Kristin Fiebelkorn -- Gene Therapy for Nonneoplastic Hematologic and Histiocytic Disorders / Kareem N. Washington, John F. Tisdale, and Matthew M. Hsieh.
  • Gross and cellular anatomy of the liver -- Liver zonation -- Hepatocytes -- Biliary epithelial cells -- Stellate cells -- Kupffer cells -- Sinusoidal endothelial cells -- Hepatic carbohydrate metabolism -- Hepatic protein metabolism -- Hepatic lipid metabolism -- Detoxification functions of the liver -- Bile acid metabolism -- Liver development -- Transcriptional control of hepatocyte differentiation -- Bile duct development and biliary differentiation -- Hepatic progenitors in development and transplantation -- Adult liver stem cells -- Liver regeneration -- Senescent liver -- Signaling pathways in the liver -- Hepatocyte transplantation -- Hepatic tissue engineering -- Hepatic gene therapy -- Liver cell death -- Macroautophagy -- Hepatic ischemia/reperfusion injury -- Inflammation and liver injury -- Oxidative stress and liver injury -- Fatty liver -- Hepatic fibrosis and cirrhosis -- Biliary cirrhosis -- Cholestasis -- Portal hypertension -- Nonalcoholic fatty liver disease -- Alcoholic liver disease -- Viral hepatitis A -- Viral hepatitis B -- Viral hepatitis C -- Viral hepatitis D -- Viral hepatitis E -- Autoimmune hepatitis -- Toxicant-induced liver injury -- Wilson's disease -- Hemochromatosis -- Glycogen storage diseases -- X1-antitrypsin deficiency -- Hepatic artery diseases -- Hepatic venous outflow obstruction -- Primary biliary cirrhosis -- Primary sclerosing cholangitis -- Biliary atresia -- Benign liver tumors -- Hepatoblastoma -- Hepatocyte growth, proliferation and experimental carcinogenesis -- Stem cells and liver cancer -- Primary hepatocellular carcinoma -- Fibrolamellular hepatocellular carcinoma -- Biology of metastatic liver tumors -- Cholangiocarcinoma -- Neoplasms of extrahepatic bile ducts -- Neoplasms of the gallbladder -- Current and future methods for diagnosis of neoplastic liver disease.
  • Part 1. Molecular Pathology of Lung Cancer: General Principles -- Approach to Personalized Care of the Lung Cancer Patient / Philip T. Cagle -- Etiology of Lung Cancer / Philip T. Cagle -- Genetic Susceptibility to Lung Cancer / Timothy Craig Allen -- Lung Cancer Stem Cells / Timothy Craig Allen -- The Classification of Pre-invasive Lesions / Keith M. Kerr -- Molecular Pathology of Precursor and Pre-invasive Lesions / Keith M. Kerr -- Revised Classification for Adenocarcinoma / Philip T. Cagle and Keith M. Kerr -- Molecular Basis for the Current Lung Cancer Classification / Alain C. Borczuk -- Molecular Diagnosis of Lung Cancer / Lucian R. Chirieac and Philip T. Cagle -- Molecular Targeted Therapy of Lung Cancer / Sanja Dacic -- Molecular Prognostic Markers of Lung Cancer / Sanja Dacic -- New Techniques for Optical and Molecular Visualization of Lung Cancer / Philip T. Cagle -- Part 2. Molecular Pathology of Lung Cancer: Specific Histologic Types -- Adenocarcinoma / Keith M. Kerr -- Squamous Cell Carcinoma / Timothy Craig Allen -- Molecular Pathology of Large Cell Carcinoma / Alain C. Borczuk -- Molecular Pathology of Small Cell Carcinomas / Mary Beth Beasley -- Molecular Biopsy of Neuroendocrine Carcinomas Other Than Small Cell Carcinoma / Mary Beth Beasley -- Molecular Pathology of Uncommon Carcinomas / Alain C. Borczuk -- Biology of Lung Cancer Metastases / Lucian R. Chirieac.
  • Section 1. Basic Concepts of Molecular Pathology -- Genes, Gene Products, and Transcription Factors / Philip T. Cagle -- Receptors, Signaling Pathways, Cell Cycle, and DNA Damage Repair / Philip T. Cagle -- Cell Adhesion Molecules / Timothy Craig Allen and Philip T. Cagle -- Apoptosis and Cell Death: Relevance to Lung / Pothana Saikumar and Rekha Kar -- Roles of Mutation and Epimutation in the Development of Lung Disease / William B. Coleman -- Section 2. Techniques and Experimental Systems in Molecular Pathology -- Bioinformatics and Omics / Timothy Craig Allen and Philip T. Cagle -- General Approach to Molecular Pathology / Gregory L. Blakey and Daniel H. Farkas -- Applications of Molecular Tests in Anatomic Pathology / Jennifer L. Hunt and Sanja Dacic -- Polymerase Chain Reaction and Reverse Transcription-Polymerase Chain Reaction / Dwight Oliver -- Array Comparative Genomic Hybridization in Pathology / Reinhard Ullmann -- Loss of Heterozygosity in Lung Diseases / Sharon C. Presnell -- In Situ Hybridization: Principles and Applications for Pulmonary Medicine / Kevin C. Halling and Amy J. Wendel -- Proteomics / Larry Fowler and Wieslaw Furmaga -- Animal Models of Lung Disease / Roberto Barrios -- Tissue Culture Models / Roger A. Vertrees, Thomas Goodwin, Jeffrey M. Jordan and Joseph B. Zwischenberger -- Section 3. Molecular Pathology of Pulmonary and Pleural Neoplasms: General Principles -- Molecular Oncogenesis of Lung Cancer / Arwen A. Stelter and Jingwu Xie -- Genetic Susceptibility / Philip T. Cagle and Timothy Craig Allen -- Prognostic Markers / Anna Sienko, Timothy Craig Allen and Philip T. Cagle -- Pulmonary Angiogenesis in Neoplastic and Nonneoplastic Disorders / Michael P. Keane and Robert M. Strieter -- Lung Cancer Stem Cells / Timothy Craig Allen and Philip T. Cagle -- Gene Therapy Approaches for Lung Cancer / Jack A. Roth -- Response to Conventional Therapy and Targeted Molecular Therapy / Timothy Craig Allen, Anna Sienko and Philip T. Cagle -- Environmental Agents in Lung and Pleural Neoplasms / Steven R. Blumen and Brooke T. Mossman -- Viral Oncogenesis / Cindy Noel Berthelot and Stephen K. Tyring -- Section 4. Molecular Pathology of Pulmonary and Pleural Neoplasms: Specific Histologic Types -- Adenocarcinoma and Its Precursor Lesions / Helmut H. Popper -- Molecular Pathology of Squamous Cell Carcinoma and Its Precursors / Soon-Hee Jung, Bihong Zhao, Li Mao and Jae Y. Ro -- Molecular Pathology of Large Cell Carcinoma and Its Precursors / Jennifer A. Eleazar and Alain C. Borczuk -- Small Cell Carcinoma / Elisabeth Brambilla -- Neuroendocrine Carcinomas and Precursors / Elisabeth Brambilla -- Pulmonary Lymphomas / Candice C. Black, Norman B. Levy and Gregory J. Tsongalis -- Posttransplantation Lymphoproliferative Disorder / Aamir Ehsan and Jennifer L. Herrick -- Unusual Benign and Malignant Neoplasms of Lung: Molecular Pathology / Dongfeng Tan, Guoping Wang and Sadir Alrawi -- Primary Versus Metastatic Cancer: Gene Expression Profiling / Jaishree Jagirdar and Philip T. Cagle -- Diffuse Malignant Mesothelioma: Genetic Pathways and Mechanisms of Oncogenesis of Asbestos and Other Agents That Cause Mesotheliomas / Françoise Galateau-Sallé and Jean Michel Vignaud -- Molecular Pathology of Pediatric Tumors of the Lung / Josefine M. Heim-Hall -- Section 5. Molecular Pathology of Pulmonary Infections -- Basis of Susceptibility to Lung Infection / Frank C. Schmalstieg and Armond S. Goldman -- Molecular Pathology of Viral Respiratory Diseases / Geoffrey A. Land -- Molecular Pathology of Rickettsial Lung Infections / J. Stephen Dumler -- Bacteria / Nabin K. Shrestha and Gary W. Procop -- Immunopathology of Tuberculosis / Jeffrey K. Actor, Robert L. Hunter and Chinnaswamy Jagannath -- Molecular Pathology of Fungal Lung Infection / Michael R. McGinnis, Michael B. Smith and Abida K. Haque -- Parasites / Juan P. Olano -- Section 6. Molecular Pathology of Other Nonneoplastic Pulmonary Diseases: General Principles -- Inflammation / Armando E. Fraire -- Oxidants and Antioxidants / Hanzhong Liu and Gary A. Visner -- Epithelial Repair and Regeneration / Steven L. Brody and Jeffrey J. Atkinson -- Fibrogenesis / John S. Munger and William N. Rom -- Stem Cells in Nonneoplastic Lung Disorders / Dani S. Zander -- Gene Therapy in Nonneoplastic Lung Disease / Timothy Craig Allen and Philip T. Cagle -- Section 7. Molecular Pathology of Other Nonneoplastic Pulmonary Diseases: Specific Entities -- Smoking-Related Lung Diseases / Manuel G. Cosio and Helmut H. Popper -- Heritable α1-Antitrypsin Deficiency / Richard N. Sifers -- Asthma / David B. Corry and Farrah Kheradmand -- Cystic Fibrosis / Annick Clement, Harriet Corvol and Brigitte Fauroux -- Pulmonary Organogenesis and Developmental Abnormalities / Timothy Craig Allen and Philip T. Cagle -- Genetic Abnormalities of Surfactant Metabolism / Lawrence M. Nogee and Susan E. Wert -- Usual Interstitial Pneumonia / Marco Chilosi, Bruno Murer and Venerino Poletti -- Sarcoidosis: Are There Sarcoidosis Genes? / Helmut H. Popper -- Histiocytic Diseases of the Lung / Carol Farver and Tracey L. Bonfield -- Pulmonary Arterial Hypertension / Wim Timens -- Immunopathology of Pulmonary Vasculitides / Steven N. Emancipator, Philip T. Cagle and Abida K. Haque -- Asbestosis and Silicosis / Philip T. Cagle and Timothy Craig Allen.
  • Introduction -- Mechanisms of Gastrointestinal Carcinogenesis /Frank I. Scott, John P. Lynch -- Epithelial Neoplastic Disease -- Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers /Davendra Sohal, Antonia R. Sepulveda, Weijing Sun -- Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma /Mamoun Younes -- Molecular Pathology of Squamous Carcinomas of the Esophagus /Rohinton S. Tarapore, Jonathan P. Katz -- Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers /Shuko Harada, Antonia R. Sepulveda -- Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes /Fátima Carneiro, Carla Oliveira, Raquel Seruca -- Cancer Predisposition Syndromes of the Gastrointestinal Tract /Ian S. Hagemann, Antonia R. Sepulveda -- Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Type /Asif Rashid -- Cancers of the Rectum and Anal Canal /Jenia Jenab-Wolcott, Bruce Giantonio -- Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia /Takeshi Uehara, Deqin Ma, Antonia R. Sepulveda -- Non-Epithelial Neoplastic Tumors -- Molecular Biology and Pathology of Gastrointestinal Stromal Tumors /Paul J. Zhang -- Neuroendocrine Tumors /Joseph R. Pisegna -- Metastatic Disease and Tumor Markers -- Molecular Mechanisms of Tumor Metastasis /Andrew D. Rhim, Davendra Sohal, Hiroshi Nakagawa -- Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis /Loren Joseph -- Serological Markers of Digestive Tract Cancers /Jorge L. Sepulveda.
  • This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.
  • Pituitary tumor classification : functionality, invasiveness, and aggressiveness -- Immunohistochemistry and electron microscopy as evaluation criteria in tumor classification in the deciphering of pituitary adenomas -- Proliferation -- Angiogenesis -- Apoptosis -- Signal transduction -- Stem cell markers in pituitary adenomas -- MicroRNAs -- New generic tools for diagnosis: genomics and proteomics -- Therapeutic approaches: drug, surgical, and radiotherapy.
  • "This book reviews the latest developments in pharmacognosy, introduces a series of new views and insights, presents the hotspots and focus of the field of study on molecular pharmacognosy, and predicts a new direction of study on the resource science of TCM. Furthermore, the book also provides an open communications platform for the development of molecular pharmacognosy."--Publisher.
  • Print Material
    Anatomy of fluid interfaces that protect the microenvironment -- Physiology of the cerebrospinal and interstitial fluids -- Neurovascular unit -- Glucose, amino acid and lipid metabolism -- Disorders of cerebrospinal circulation : idiopathic intracranial hypertension (IIH) and hydrocephalus -- Quantification of cerebral blood flow and blood brain barrier transport by NMR and PET -- Mechanisms of ischemic/hypoxic brain injury -- Vascular cognitive impairment and Alzheimer's disease -- Effects of altitude on the brain -- Brain edema -- Intracerebral hemorrhage -- Autoimmunity, hypoxia, and inflammation in demyelinating diseases.
  • Contributors -- Part 1. The DEG/ENaC family -- 1. The role of DEG/ENaC ion channels in sensory mechanotransduction / Dafni Bazopoulou, Giannis Voglis, and Nektarios Tavernarakis -- 2. ASICs function as cardiac lactic acid sensors during myocardial ischemia / Christopher J. Benson and Edwin W. McCleskey -- 3. Molecular components of neural sensory transduction DEG/ENac proteins in baro and chemoreceptors / François M. Abboud, Yongjun Lu, and Mark W. Chapleau -- Part II. The TRP family -- 4. TRP channels as molecular sensors of physical stimuli / Roger G. O'Neill -- 5. TRPV1 in central cardiovascular control : discerning the C-fiber afferent pathway / Michael C. Andersen, Mark W. Doyle, Timothy W. Bailey, and Young-Ho Jin -- 6. TRPV1 as a molecular transducer for salt and water homeostasis / Donna H. Wang and Jeffrey R. Sachs -- 7. Functional interaction between ATP and TRPV1 receptors / Makoto Tominaga and Tomoko Moriyama -- 8. TRPV4 and hypotonic stress / David M. Cohen -- Part III. Other ion channels and biosensors -- 9. Ion channels in shear stress sensing in vascular endothelium : ion channels in vascular mechanotransduction / Abdul I. Barakat, Deborah K. Lieu, and Andrea Gojova -- 10. Redox signaling in oxygen sensing by vessels / Andrea Olschewski and E. Kenneth Weir -- 11. Impedance spectroscopy and quartz crystal microbalance : noninvasive tools to analyze ligand-receptor interactions at functionalized surfaces and of cell monolayers / Andreas Hinz and Hans-Joachim Galla -- Index.
  • Molecular Pathology of Colorectal Cancer / Fred T. Bosman -- Molecular Pathology of Pancreatic Cancer / Laura D. Wood, N. Volkan Adsay and Ralph H. Hruban -- Molecular Pathology of Liver Tumors / Thomas Longerich, Kai Breuhahn and Peter Schirmacher -- Molecular Pathology of Gallbladder Cancer / Juan Carlos Roa and N. Volkan Adsay -- Molecular Pathology of Lung Cancers / Lynette M. Sholl and Neal I. Lindeman -- Molecular Pathology of Breast Cancer / Alejandro Ariel Gru and Donald Craig Allred -- Molecular Pathology of Ovarian Cancer / Kruti P. Maniar, Ie-Ming Shih and Robert J. Kurman -- Molecular Pathology of Endometrial Cancer / Xavier Matias-Guiu and Jaime Prat -- Molecular Pathology of Kidney Tumors / Sean R. Williamson, John N. Eble and Liang Cheng -- Molecular Pathology of Prostate Cancer / Bora Gurel, Riley E. Alexander, Liang Cheng and Angelo M. De Marzo -- Molecular Pathology of Urinary Bladder Cancer / George J. Netto and Liang Cheng -- Molecular Pathology of Testicular Cancer / Katharina Biermann and Leendert H. J. Looijenga -- Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer / Andrea Saggini and Boris Bastian -- Molecular Pathology of Head and Neck Cancer / Audrey P. Calzada, Maie A. St. John, Elliot Abemayor and David T. W. Wong -- Molecular Pathology of Soft Tissue and Bone Tumors / Neal I. Lindeman and Paola Dal Cin -- Molecular Pathology of the Central Nervous System / Brent T. Harris and Eyas M. Hattab -- Molecular Pathology of Endocrine Cancer / Ricardo V. Lloyd, Long Jin, Darya Buehler, Heather Hardin and Weihua Shan.
  • ch. 1. Approaches to a molecular switch using photoinduced electron and energy transfer -- ch. 2. Photoswitchable molcular systems based on diarylethenes -- ch. 3. Optoelectronic molecular switches based on dihydroazulene-Vinylheptafulvene (DHA0VHF) -- ch. 4. Molecular switches with photochromic fulgides -- ch. 5. Chiroptical molecular switches -- ch. 6. Photochemical biomolecular switches: the route to optobioelectronics -- ch. 7. Switchable catenanes and molecular shuttles -- ch. 8. Metallo-rotaxanes and catenanes as redox switches : towards molecular machines and motors -- ch. 9. Switchable molecular receptors and recognition processes : from photoresponsive crown ethers to allosteric sugar sensing systems -- ch. 10. Multistate/multifunctional molecular-level systems : photochromic flavylium compounds -- ch. 11. Molecular logic systems -- ch. 12. Liquid crystal photonics : opto-photochemical effects in photoresponsive liquid crystals -- ch. 13. Photoswitchable polypeptides.
  • Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers. Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.
  • The application of modern molecular genetic and biologic techniques to infectious disease epidemiology dramatically improves measurement of disease and putative risk factors increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. We examine these opportunities and methodologic challenges giving specific examples. The book will be written for the reader with limited understanding of genetics, biology and epidemiology. *Presents the key points of consideration when integrating molecular biology and epidemiology *Discusses how using molecular tools in epidemiologic research affects program design and conduct *Considers the ethical concerns that arise in molecular epidemiologic studies *Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field.
  • Molecular toxicology protocols 2004
    Springer Protocols
    Analysis of K-RAS and P53 mutations in sputum samples / Weimin Gao and Phouthone Keohavong -- Allele-specific competitive blocker-PCR detection of rare base substitution / Barbara L. Parsons, Page B. McKinzie, and Robert H. Heflich -- Gel-based nonradioactive single-strand conformational polymorphism and mutation detection: limitations and solutions / Vibhuti Gupta ... [et al.] -- Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions / Toshinari Minamoto -- Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR / Michael J. Villalobos, Christopher J. Betti, and Andrew T.M. Vaughan -- Microsatellite instability: an indirect assay to detect defects in the cellular mismatch repair machinery / Anjana Saha, Narendra K. Bairwa, and Ramesh Bamezai -- Unscheduled DNA synthesis: a functional assay for global genomic nucleotide excision repair / Crystal M. Kelly and Jean J. Latimer -- Analysis of DNA repair using transfection-based host cell reactivation / Jennifer M. Johnson and Jean J. Latimer -- An immunoassay for measuring repair of ultraviolet photoproducts / Shirley McCready -- Analysis of DNA double-strand break repair by nonhomologous end joining in cell-free extracts from mammalian cells / Petra Pfeiffer ... [et al.] -- The comet-FISH technique: a tool for detection of specific DNA damage and repair / Alexander Rapp, Michael Hausmann, and Karl Otto Greulich -- DNA double-strand break damage and repair assessed by pulsed-field gel electrophoresis / Nina Joshi and Stephen G. Grant -- Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes / Vasily N. Dobrovolsky, Joseph G. Shaddock, and Robert H. Heflich -- Quantifying in vivo somatic mutations using transgenic mouse model systems / Roy R. Swiger -- Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants / Sai-Mei Hou -- Molecular analysis of mutations in the human HPRT gene / Phouthone Keohavong, Liqiang Xi, and Stephen G. Grant -- Simultaneous quantification of t(14;18) and HPRT exon 2/3 deletions in human lymphocytes / James C. Fuscoe -- The GPA in vivo somatic mutation assay / Stephen G. Grant -- Flow cytometric measurement of mutant T cells with altered expression of TCR: detecting somatic mutations in humans and mice / Seishi Kyoizumi, Yoichiro Kusunoki, and Tomonori Hayashi -- Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis / Therese Sørlie ... [et al.] -- ³²P-postlabeling analysis of DNA adducts / David H. Phillips, Alan Hewer, and Volker M. Arlt -- Modification of the ³²P-postlabeling method to detect a single adduct as a single spot / Masako Ochiai, Takashi Sugimura, and Minako Nagao -- DNA isolation and sample preparation for quantification of adduct levels by accelerator mass spectrometry / Karen H. Dingley ... [et al.] -- Fluoroimaging-based immunoassay of DNA photoproducts in ultraviolet-B-irradiated tadpoles / Iovanna Pandelova, Stephen R. Hewitt, and John B. Hays -- Analysis of DNA strand cleavage at abasic sites / Walter A. Deutsch and Vijay Hegde -- Premature chromosome condensation in human resting peripheral blood lymphocytes for chromosome aberration analysis using specific whole-chromosome DNA hybridization probes / Pataje G.S. Prasanna and William F. Blakely -- Mutagen-induced chromatid breakage as a marker of cancer risk / Xifeng Wu, Yun-Ling Zheng, and T.C. Hsu -- Flow cytometric analysis of micronuclei in erythrocytes / Jan Grawé -- The comet assay: a sensitive genotoxicity test for the detection of DNA damage / Günter Speit and Andreas Hartmann -- Computerized image analysis software for the comet assay / R.C. Chaubey -- Measuring recombination proficiency in mouse embryonic stem cells / Andrew J. Pierce and Maria Jasin -- Strategies for measurement of biotransformation enzyme gene expression / Marjorie Romkes and Shama C. Buch -- Genotyping technologies: application to biotransformation enzyme genetic polymorphism screening / Marjorie Romkes and Shama C. Buch -- TaqMan® fluorogenic detection system to analyze gene transcription in autopsy material / Kaori Shintani-Ishida, Bao-Li Zhu, and Hitoshi Maeda -- Development of quantitative reverse transcriptase PCR assays for measuring gene expression / Tony E. Godfrey and Lori A. Kelly -- Quantification of selective phosphatidylserine oxidation during apoptosis / James P. Fabisiak ... [et al.] -- Quantitative method of measuring of phosphatidylserine externalization during apoptosis using electron paramagnetic resonance spectroscopy and annexin-conjugated iron / James P. Fabisiak, Grigory G. Borisenko, and Valerian E. Kagan -- Detection of programmed cell death in cells exposed to genotoxic agents using a caspase activation assay / Michael E. Gehring and Patrick P. Koty.
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  • Part 1. General consideration on microorganism typing methods -- Molecular Epidemiology / Amy E. Seitz and D. Rebecca Prevots -- Part 2. Gastrointestinal Pathogens -- Enterococcus / Lúcia Martins Teixeira and Vânia Lúcia Carreira Merquior -- Listeria monocytogenes / Todd J. Ward -- Enterobacteriaceae / Steven L. Foley, Aaron M. Lynne and Rajesh Nayak -- Molecular Typing of Vibrio cholerae: Imprints in the Epidemiology of Cholera / T. Ramamurthy, A. K. Mukhopadhyay, R. K. Nandy and G. Balakrish Nair -- Molecular Typing of Clostridium difficile / Andrej Weintraub and Carl Erik Nord -- Oral and Intestinal Bacteroidetes / Marina C. Claros and Georg Conrads -- Part 3. Oral and Respiratory Pathogens -- Streptococci / Lesley McGee and Bernard Beall -- Molecular Typing of Streptococcus mutans / Kazuhiko Nakano, Ichiro Nakagawa, Satu Alaluusua and Takashi Ooshima -- Genotyping of Periodontal Anaerobic Bacteria in Relationship to Pathogenesis / Masae Kuboniwa and Atsuo Amano -- Molecular Typing of Nontuberculous Mycobacteria / Jakko van Ingen and Dick van Soolingen -- Molecular Typing of Neisseria meningitidis / Muhamed-Kheir Taha and Ala-Eddine Deghmane -- Molecular Typing in Bacterial Infections Haemophilus spp. / Marina Cerquetti -- Moraxella / Nevada M. Pingault and Thomas V. Riley -- Legionella pneumophila Typing / Christophe Ginevra -- Mycoplasma and Ureaplasma / Ken B. Waites, Li Xiao, Vanya Paralanov, Rose M. Viscardi and John I. Glass -- Corynebacterium diphtheriae / Igor Mokrousov -- Burkholderia / Pavel Drevinek and Eshwar Mahenthiralingam -- Part 4. Urogenital Pathogens -- Treponema / Allan Pillay -- Chlamydiaceae / Troy Skwor and Deborah Dean -- Part 5. Vector borne Pathogens -- Borreliae / Dionysios Liveris, Klára Hanincová and Ira Schwartz -- Erysipelothrix / Yumiko Imada -- Part 6. Pathogens causing Healthcare-Associated Infection -- Staphylococci / Jodi A. Lindsay -- Molecular Typing Methods for the Genus Pseudomonas / Balázs Libisch -- Part 7. Emerging and Reemerging Pathogens -- Acinetobacter baumannii / Lenie Dijkshoorn -- Molecular Typing of Coxiella burnetii: A Review of Available Methods with Major Focus on PCR-Based Techniques / V. Boldis, E. Spitalska and R. Toman.
  • This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer.
  • This title discusses all aspects of non-infectious and non-cancer -- so called NINC -- vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. Practical perspectives of patentability of vaccines are discussed. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.
  • Molecular virology 2013
    The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.
  • Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • Integrating molecular knowledge in clinical decision-making for personalized cancer management -- Gastrointestinal stromal tumors -- Metastatic melanoma -- Ovarian cancer -- Triple-negative breast cancer -- Gastric cancer -- Pleural mesothelioma -- Lung adenocarcinoma.
  • Part 1. Hematologic Malignancies -- The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia / William L. Carroll and Rob Pieters -- Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia / Alejandro Gutierrez and A. Thomas Look -- Molecularly Targeted Therapy for Infant ALL / Patrick A. Brown and Carolyn A. Felix -- Targeted Therapeutic Approaches for AML / Robert J. Arceci and Donald Small -- Acute Promyelocytic Leukaemia / Andrea Biondi, Anna Maria Testi and Brenda E. S. Gibson -- Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy / Jeffrey W. Taub, Yubin Ge and Yaddanapudi Ravindranath -- Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML) / Jennifer O'Hara Lauchle and Benjamin S. Braun -- Chronic Myeloid Leukemia: Pathophysiology and Therapeutics / Seth J. Corey and Jorge Cortes -- Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes / Lia Gore -- New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma / Megan S. Lim and Mitchell S. Cairo -- Molecular Targeting of Post-transplant Lymphoproliferative Disorders / Michael Wang and Thomas G. Gross -- Part 2. Solid Tumors -- Molecularly Targeted Therapies for Astrocytomas / Ian F. Pollack -- Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer / Yoon-Jae Cho and Scott L. Pomeroy -- Future Treatments of Ependymoma / Richard J. Gilbertson -- Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INI1/hSNF5 Tumor Suppressor / Ganjam V. Kalpana and Melissa E. Smith -- Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors / Brigitte Widemann -- Molecular Therapy for Neuroblastoma / Yaël P. Mossé and John M. Maris -- Ewing's Sarcoma Family of Tumors: Molecular Targets Need Arrows / Jeffrey A. Toretsky and Aykut Üren -- Molecular Targeted Therapy for Wilms' Tumor / James I. Geller and Jeffrey S. Dome -- Molecular Therapy for Rhabdomyosarcoma / Raushan T. Kurmasheva, Hajime Hosoi, Ken Kikuchi and Peter J. Houghton -- Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here? / Rosanna Ricafort and Richard Gorlick -- Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology / Stephen X. Skapek.
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    "Key to making future advances in the areas of biochemistry and molecular medicine is a new generation of molecular biologists and biochemists who are able to harness the tools and insights of physics and chemistry to exploit the emergence of genomic and systems-level information in biology.The basic ideas of energy, entropy, equilibrium thermodynamics, transport processes and reaction kinetics are closely related to exciting issues in contemporary biology, such as protein folding, chaperones and prion diseases, DNA polymerase and ribosome fidelity, DNA recognition, drug design, signal transduction, ion channel function, motor protein action and the versatility of enzyme mechanism." ... "Molecules of Life" ... deepens our understanding of how life functions by illuminating the physical principles underpinning biological phenomena." --Excerpts from publisher notes.
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    Blood donors and the withdrawal of blood -- Transfusion of blood, blood components and plasma alternatives in oligaemia -- Immunology of red cells -- ABO, Lewis, and P groups and Ii antigens -- The Rh blood group system (and LW) -- Other red cell antigens -- Red cell antibodies against self antigens, bound antigens and induced antigens bound antigens and induced antigens -- Blood grouping techniques -- The transfusion of red cells -- Red cell incompatibility in vivo -- Haemolytic transfusion reactions -- Haemolytic disease of the fetus and the newborn -- Immunology of leucocytes, platelets and plasma components -- The transfusion of platelets, leucocytes, haemopoietic cells and plasma components -- Some unfavourable effects of transfusion -- Infectious agents transmitted by transfusion -- Haemopheresis -- Alternatives to blood transfusion.
  • "Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field"--Provided by publisher.
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    1. The road to corporate medicine -- 2. The cost of competition : an overview -- 3. For-profit hospitals : a flaw in the business model? -- 4. Not-for-profit hospitals : "no margin, no mission"? -- 5. When more care is not better care -- 6. "Too little, too late" : the cost of rationing care -- 7. Doing less and doing it right : is pay for performance the answer? -- 8. Device makers, drugmakers, and the FDA -- Where we are now : everyone out of the pool.
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    "The original targets for these Goals were a two-thirds reduction in the mortality of children under 5 and a three-quarters reduction in the maternal mortality ratio between 1990 and 2015. There is worldwide consensus that, in order to reach these targets, good-quality essential services must be integrated into strong health systems. The addition in 2007 of a new target in Goal 5--universal access to reproductive health by 2015--reinforces this consensus: all people should have access to essential maternal, newborn, child and reproductive health services provided in a continuum of care. In order to reduce maternal mortality, Emergency Obstetric Care (EmOC) must be available and accessible to all women. While all aspects of reproductive health care including family planning and delivery with the help of a skilled health professional also plays an important role in reducing maternal and neonatal mortality, this handbook focuses on the critical role of EmOC in saving the lives of women with obstetric complications during pregnancy and childbirth and saving the lives of newborns intrapartum. The handbook describes indicators that can be used to assess, monitor and evaluate the availability, use and quality of EmOC." - p. vi This handbook describes indicators that can be used to assess, monitor and evaluate the availability, use and quality of Emergency Obstetric Care. These emergency obstetric care indicators can be used to measure progress in a programmatic continuum: from the availability of and access to emergency obstetric care to the use and quality of those services.
  • Ideal for neurosurgeons, neurologists, neuroanesthesiologists, and intensivists, this book helps you use the latest technology to more successfully detect deteriorations in neurological status in the ICU. This neurosurgery reference offers in-depth coverage of state-of-the-art management strategies and techniques so you can effectively monitor your patients and ensure the best outcomes.
  • This is an introduction to the patient monitoring technologies that are used in today's acute care environments, including the operating room, recovery room, emergency department, intensive care unit, and telemetry floor. To a significant extent, day-to-day medical decision-making relies on the information provided by these technologies, yet how they actually work is not always addressed during education and training. The editors and contributors are world-renowned experts who specialize in developing, refining, and testing the technology that makes modern-day clinical monitoring possible. Their aim in creating the book is to bridge the gap between clinical training and clinical practice with an easy to use and up-to-date guide. ·How monitoring works in a variety of acute care settings ·For any healthcare professional working in an acute care environment ·How to apply theoretical knowledge to real patient situations ·Hemodynamic, respiratory, neuro-, metabolic, and other forms of monitoring ·Information technologies in the acute care setting ·New and future technologies.
  • Recognition & management of the deteriorating patient -- Assessment of the critically ill patient -- Monitoring respiratory function -- Monitoring cardiovascular function 1 : ECG monitoring -- Monitoring cardiovascular function 2 haemodynamic monitoring -- Monitoring neurological function -- Monitoring renal function -- Monitoring gastrointestinal function -- Monitoring hepatic function -- Monitoring endocrine function -- Monitoring nutritional status -- Monitoring temperature -- Monitoring pain -- Monitoring a patient receiving a blood transfusion -- Monitoring the patient with infection and related systemic inflammatory response -- Monitoring the critically ill, pregnant patient -- Monitoring the critically ill child -- Monitoring during transport -- Record keeping.
  • Part I. Techniques of Monitoring -- Chapter 1. Somatosensory Evoked Potentials -- Chapter 2. Transcranial Motor Evoked Potentials -- Chapter 3. Auditory Evoked Potentials -- Chapter 4. VEP -- Chapter 5. Deep Brain Stimulation -- Chapter 6. Spinal Cord Stimulation Techniques -- Chapter 7. Electromyography -- Chapter 8. Cortical Mapping -- Chapter 10. Near-Infrared Spectroscopy -- Chapter 11. Transcranial Doppler -- Chapter 12. Jugular Bulb Monitoring -- Chapter 13. Monitoring Intracranial Pressure -- Part II. Anesthesia Considerations -- Chapter 14. Anesthesia for Awake Neurosurgery -- Chapter 15. General Anesthesia for Monitoring -- Chapter 16. Monitoring Anesthetic Effect -- Part III. Case-Based Presentations -- Chapter 17. Monitoring Applications and Evaluating Changes, Algorithm -- Chapter 18. Intracranial Aneurysm Clipping -- Chapter 19. Intracranial AVM Surgery -- Chapter 20. Surgery for Supratentorial Mass -- Chapter 21. Surgery for Infratentorial Mass -- Chapter 22. Microvascular Surgery for Trigeminal Neuralgia -- Chapter 23. Surgery for Hemifacial Spasm -- Chapter 24. Skull Base Surgery -- Chapter 25. Surgery for Arnold Chiari Malformation -- Chapter 26. ENT and Anterior Neck Surgery -- Chapter 27. Carotid Surgery -- Chapter 28. Anterior Cervical Spine Surgery -- Chapter 29. Posterior Cervical Spine Surgery -- Chapter 30. Surgery for Scoliosis Correction -- Chapter 31. Surgery on the Thoracic Spine -- Chapter 32. Surgery in the Lumbo-Sacral Spine -- Chapter 33. Intramedullary Spinal Cord Surgery -- Chapter 34. Surgery for Tethered Cord -- Chapter 35. Surgery in the Peripheral Nervous System -- Chapter 36. Surgery of the Aortic Arch -- Chapter 37. Surgery on Thoraco-Abdominal Aneurysms -- Chapter 38. Monitoring During Cardiopulmonary Bypass -- Chapter 39. Interventional Neuroradiology -- Part IV. Intensive Care Monitoring -- Chapter 40. Monitoring in Intensive Care -- Chapter 41. Monitoring Cerebral Blood Flood -- Afterword. Future of Monitoring the Nervous System.
  • Monoclonal antibodies in contemporary cancer therapy / Fatih M. Uckun -- mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment / Letizia Polito, Rossella Mancuso, Daniele Mercatelli, Massimo Bortolotti & Andrea Bolognesi -- mAbs targeting CTLA-4 and clinical outcomes / Francesco Spagnolo, Virginia Picasso & Paola Queirolo -- mAbs targeting VEGF/VEGFR and clinical outcomes in cancer treatment / Brendan Curley, Michael Newton & Jame Abraham -- mAbs targeting RANKL in bone metastasis treatment / Bérengère Gobin, Marc Baud'Huin, Bertrand Isidor, Dominique Heymann & Marie-Françoise Heymann -- Novel mAb-based therapies for leukemia / Osmond J. D'Cruz & Fatih M. Uckun -- Index.
  • Monoclonal antibodies targeting EGFR/HER2 and clinical outcomes in cancer treatment / Jan B. Vermorken -- Colorectal cancer / Christian Rolfo, Giuseppe Bronte, Antonio Russo & Marc Peeters -- Breast cancer / Sevilay Altintas -- Lung cancer and genitourinary cancers / Dirk Schrijvers -- Tumors of the skin, the CNS and the head and neck / Pol Specenier -- Gynecologic cancers / Jan B. Vermorken -- Index.
  • Historical perspective on the genetic forms of congenital hyperinsulinism / Stanley, C.A., Matschinsky, F.M. -- Biochemistry and physiology of the ATP-sensitive potassium channel / Remedi, M.S., Nichols, C.G. -- Pathophysiology of diffuse ATP-sensitive potassium hyperinsulinism / De León, D.D., Stanley, C.A. -- Molecular defects of ATP-sensitive potassium channels in congenital hyperinsulinism / Shyng, S.-L. ... [et al.] -- Molecular mechanisms and clinical pathophysiologies of focal ATP-sensitive potassium hyperinsulinism and Beckwith-Wiedemann Syndrome / Arnoux, J.-B. ... [et al.] -- Pancreatic histopathology of hyperinsulinism / Suchi, M., Bhatti, T.R., Ruchelli, E.D. -- Localization of a focal lesion of congenital hyperinsulinism : imaging and surgery / States, L.J., Adzick, N.S. -- Role of incretin hormones in hyperinsulinemic hypoglycemia / De León, D.D. -- Glutamate dehydrogenase : structure, regulation, and its role in insulin homeostasis / Smith, T.J. -- Congenital hyperinsulinism due to activating mutations of glutamate dehydrogenase : the hyperinsulinism/hyperammonemia syndrome / Kelly, A., Palladino, A., Stanley, C.A. -- Amino acid-stimulated insulin secretion : the role of the glutamine-glutamate-alpha-ketoglutarate axis / Li, C., Matschinsky, F.M., Stanley, C.A. -- Tissue specificity of glutamate dehydrogenase as illustrated in pancreatic beta-cells and the central nervous system / Carobbio, S. ... [et al.] -- The molecular genetics and pathophysiology of congenital hyperinsulinism caused by short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency / Molven, A. ... [et al.] -- Hyperinsulinism due to activating mutations of glucokinase / Sayed, S., Matschinsky, F., Stanley, C.A. -- Hyperinsulinism due to mutations of uncoupling protein 2 / Del Mar Gonzalez-Barroso, M., de Lonlay, P., Ricquier, D. -- Exercise-induced hyperinsulinism : a failure of monocarboxylate transporter 1 expression silencing / Otonkoski, T., Meissner, T. -- HNF4A and hyperinsulinemic hypoglycemia / Kapoor, R.R., James, C.T., Hussain, K.
  • vol. 1. Protospathidiidae, Arcuospathidiidae, Apertospathulidae --
  • Foreword -- 1. Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes -- 2. Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants -- 3. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions -- 4. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1 -- 5. Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples With Single Substrates -- 6. Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and their Role in Cardiovascular Disease -- 7. Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s -- 8. Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates,- 9. Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources -- 10. Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs -- 11. Biological Diversity of Cytochrome P450 Redox Partner Proteins -- 12. Cytochrome P450cin (CYP176A1) -- 13. Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins that Combine Peroxidase and Cytochrome P450 Properties.
  • The metaphor of the monster or predator usually a sexual predator, drug dealer in areas frequented by children, or psychopathic murderer is a powerful framing device in public discourse about how the criminal justice system should respond to serious violent crimes. The cultural history of the monster reveals significant features of the metaphor that raise questions about the extent to which justice can be achieved in both the punishment of what are regarded as ""monstrous crimes"" and the treatment of those who commit such crimes. This book is the first to address the connections between the ...
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  • "Preface Monte Carlo methods have become an important tool for exploring complicated systems and especially for investigation of imaging parameters in nuclear medicine. By using sampling methods based on probability distribution function in combination with methods that simulate the various particle interaction that can occur, a detailed radiation transport can be simulated from the patient into the imaging system. Monte Carlo simulation does not replace experimental measurements but offers a unique possibility to gain understanding in the underlying physics phenomena that form nuclear medicine images. It also provides a substantial help to researchers to develop methods for image improvement. When combining an accurate model of the imaging system and a realistic model of the patient's geometry and activity distribution, the simulated images can be highly clinically realistic and almost undistinguishable from a real patient measurement. The first edition of this book was published in 1998. It was one of the first books that combined a description of the Monte Carlo methods and principles with relevant Monte Carlo programs and applications in the field of diagnostic nuclear medicine. It is now 14 years since that publication and we therefore felt that it was important to have a second edition since new and very powerful Monte Carlo programs and methods have become available. This new edition provides the background to, and a summary of, the current Monte Carlo techniques that are in use today. The focus is still on the diagnostic imaging application but several programs that are described in the book also allow for charge-particle simulations applicable to dosimetryrelated applications"-- Provided by publisher.
  • "Preface Drug development, aiming at improving people's health, becomes more costly every year. The pharmaceutical industry must join its efforts with government and health professions to seek new, innovative, and cost- effective approaches in the development process. During this evolutionary process in the next decades, computer simulations will no doubt play a critical role. Computer simulation or Monte Carlo is the technique of simulating a dynamic system or process using a computer program. Computer simulations, as an efficient and effective research tool, have been used virtually in every concern of engineering, science, mathematics, etc. In this book, I am going to present the concept, theory, algorithm, and cases studies of Monte Carlo simulation in the pharmaceutical and health industries. The concepts refer not only to simulation in general, but also to various types of simulations in drug development. The theory will include virtual data sampling, game theory, deterministic and stochastic decision theories, adaptive design methods, Petrinet, genetic programming, resampling methods, and other strategies. These theories and methods either are necessary to carry out the simulations or make the simulations more efficient, even though there are many practical problems that can be simulated directly in ad hoc fashion without any theory of their efficiency or convergence considerations. The algorithms, which can be descriptive, computer pseudocode, or a combination of both, provide the basis for implementation of simulation methods. The case studies or applications are the simplified versions of the real world problems. These simplifications are necessary because a single case could otherwise occupy the whole book, preventing readers from exploring broad issues"--Provided by publisher.
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    Course of psychiatric illness during pregnancy and the postpartum / Laura Fagioli Petrillo ... [et al.] -- Diagnosis and treatment of mood and anxiety disorders in pregnancy / Ruta M. Nonacs ... [et al.] -- Management of bipolar disorder during pregnancy and the postpartum period: weighing the risks and benefits / Adele C. Viguera ... [et al.] -- Postpartum mood disorders / Ruta M. Nonacs -- Use of antidepressants and mood stabilizers in breast-feeding women / Kimberly Ragan, Zachary N. Stowe, and D. Jeffrey Newport.
  • Justifying moral claims in a pluralistic society -- Engelhardt and the content-free (?) principle of permission -- Four-principles approach: an appeal to the common morality for resolution and justification -- Casuistry in a pluralistic society -- Moral acquaintanceships as a means of the conflict resolution.
  • The immoral brain / Andrea L. Glenn and Adrian Raine -- "Extended attachment" and the human brain : internalized cultural values and evolutionary implications / Jorge Moll and Ricardo de Oliveira-Souza -- Neuro-cognitive systems involved in moral reasoning / James Blair -- Empathy and morality : integrating social and neuroscience approaches / Jean Decety and C. Daniel Batson -- Moral judgment and the brain : a functional approach to the question of emotion and cognition in moral judgment integrating psychology, neuroscience and evolutionary biology / Kristin Prehn and Hauke R. Heekeren -- Moral dysfunction : theoretical model and potential neurosurgical treatments / Dirk De Ridder ... [et al.] -- Does it pay to be good? Competing evolutionary explanations of pro-social behaviour / Matthijs van Veelen -- How can evolution and neuroscience help us understand moral capacities? / Randolph M. Nesse -- Runaway soical selection for displays of partner value and altruism / Randolph M. Nesse -- The evolved brain : understanding religious ethics and religious violence / John Teehan -- An evolutionary and cognitive neuroscience perspective on moral modularity / Jelle De Schrijver.
  • From destiny to freedom? : on human nature and liberal eugenics in the age of genetic manipulation / Michela Betta -- Diagnostic knowledge in the genetic economy and commerce / Michela Betta -- Body talk : genetic screening as a device of crime regulation / Richard Hil, Richard Hindmarsh -- Genetic testing and human genetic databases / Astrid H. Gesche -- The imperative of the "new genetics" : challenges for ethics, law, and social policy / David Weisbrot -- Insurance and genetics : regulating a private market in the public interest / David Weisbrot, Brian Opeskin -- The social imperative for community genetic screening : an Australian perspective / MaryAnne Aitken, Sylvia Metcalfe -- Genetically transformed healthcare : healthy children and parents / Enzo A. Palombo, Mrinal Bhave -- The Australian law reform inquiry into genetic commission testing - a worker's perspective / Susan Pennicuik -- Genetic information and the Australian labour movement / Suzanne Jamieson -- Protecting the vulnerable : genetic testing and screening for parentage, immigration, and aboriginality / Astrid H. Gesche -- Essentially whose? : genetic testing and the ownership of genetic information / Lyn Turney -- Self-knowledge and self-care in the age of genetic manipulation / Michela Betta.
  • Morality in context 2005
    The meaning of moral ought / Jürgen Habermas -- Between Aristotle and Kant : sketch of a morality of recognition / Axel Honneth -- Contexts of recognition : comments on Axel Honneth's moral perspective beyond Aristotle and Kant / Micha Brumlik -- Emotions and the origins of morality / Martha C. Nussbaum -- What should count as moral behavior? The nature of "early morality" in children's development / Augusto Blasi -- Discourse in context / Vilhjálmur Árnason -- Moral intimacy and moral judgment : tailoring general theories to personal contexts / Bill Puka -- Moral resilience : the unhappy moralist / Fritz K. Oser and Roland Reichenbach -- Do concepts matter? The impact of a justice framing on responses to a moral dilemma : a research note / Rainer Döbert and Natalie Juranek -- The discontents and contents in cultural practices : it depends on where you sit / Elliot Turiel -- Changes in moral understanding : an intergenerational comparison / Gertrud Nunner-Winkler -- Is community compatible with autonomy? Cultural ideals versus empirical realities / Joan G. Miller -- Is community compatible with autonomy? Some comments to Joan Miller's research on differing moralities in India and the United States / Lothar Krappmann -- Reasoning about moral obligations and interpersonal responsibilities in different cultural contexts / Monika Keller ... [et al.] -- Partiality and identity : psychological research on preferential behavior toward group members / Mordecai Nisan -- Culture, context, and the psychological sources of human rights concepts / Larry Nucci -- To forgive and forget / Avishai Margalit.
  • As the worldwide prevalence of morbid obesity among adolescents continues to rise, recent years have seen a large increase in the performance of adolescent bariatric surgery. While surgical intervention often becomes necessary when conservative weight-loss therapies have failed, no standards regarding the post-operative regimen and long-term management of adolescent patients have been established. Thus, the treatment of obesity and its co-morbidities requires a multidisciplinary approach, taking into account epidemiological, clinical, nutritional, and genetic aspects of morbid obesity in the pediatric age group. This volume discusses both conventional therapy and surgical options for morbid obesity in the pediatric age group. In the first part, obesity-related diseases, genetics, and psychological factors are analyzed. The second part focuses on current bariatric surgery procedures, including dietary restrictions and guidelines to prevent nutritional deficiencies common after surgery. Therefore, the book will prove an invaluable resource for pediatricians, surgeons, nutritionists, dieticians, and all other health professionals who treat adolescent obesity.
  • Modified Cretan Mediterranean diet in the prevention of coronary heart disease and cancer: an update / de Lorgeril, M., Salen, P. -- Endothelial nitric oxide synthase as a mediator of the positive health effects of Mediterranean diets and wine against metabolic syndrome / Leighton, F., Urquiaga, I. -- Effects of an omega-3-enriched Mediterranean diet (modified diet of Crete) versus a Swedish diet / Friberg, P., Johansson, M. -- Dietary fat intake of European countries in the Mediterranean area: an update / Marangoni, F., Martiello, A., Galli, C. -- The Mediterranean diet in Italy: an update / Rubba, P. ... [et al.] -- A Mediterranean diet is not enough for health: physical fitness is an important additional contributor to health for the adults of tomorrow / Castillo-Garzón, M.J. ... [et al.] -- Mediterranean diet in the Maghreb: an update / Zeghichi-Hamri, S., Kallithraka, S. -- Antioxidants in the Mediterranean diets: an update / Bogani, P., Visioli, F. -- Olive oil / Boskou, D. -- Melatonin in edible plants (phytomelatonin): identification, concentrations, bioavailability and proposed functions / Reiter, R.J. ... [et al.].
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    Introduction. Healing and enhancing -- 1. Designer bodies -- 2. Designer minds -- 3. Created equal -- 4. Methuselah's genes -- 5. Designer lifespans -- 8. Methuselah's world -- 7. A child of one's own -- 8. Designer children -- 9. The wired brain -- 10. World wide mind -- 11. Life without limits.
  • Morgan & Mikhail's Clinical anesthesiology 2013 (5th ed.)
  • Why the investigation was started -- Materials and methodology -- Evidence not recorded on videotape -- The phenomenon of the disappearing hair follicles -- Particles entering the eyes -- Particles exiting the eyes -- A substance that transverses the optic globe -- The irregular iris -- Particles that exit the feet -- Particles that enter the feet -- The microorganism mobility : an internal propulsion system -- Green feet illuminate the role of the epidermis in the life-cycle of the microorganism -- Coated hairs under the microscope -- The micro organism possibly growing on a piece of cocaine -- A summary of the observations -- The structure of the microorganism -- A model accounting for the observed phenomena -- Is there a cure? -- Future considerations : a microorganism as an etiology for delusional parasitosis.
  • This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • Introduction -- Morphological aspects of tumor vasculature -- Mechanisms of control of angiogenesis in tumor vasculature -- Anti-Angiogenesis and vascular targeting in tumor vasculature.
  • This book combines state-of-the-art expertise from a variety of diverse pathogen model systems to provide an update to our current understanding of the regulation of fungal morphogenesis as a key determinant of pathogenicity in fungi.
  • This book approaches inner ear diseases from a perspective that is as multifaceted as the diseases themselves. Common among these disorders are sudden deafness, Mnires disease, and perilymphatic fistula. With an awareness of the generally insufficient understanding of the causes and etiologies of these and other inner ear diseases, the author helps to fill those gaps in knowledge. Several factors have impeded a clearer understanding of inner ear diseases, chiefly the small size of the organ and its location in the hard temporal bone and, consequently, the inadequate resolution of CT and MRI images for pathophysiological analysis. This book provides morphological information about the inner ear, elucidating its fluids and blood vessels to help familiarize the reader with the complicated inner ear structures. Important information about how the inner ear responds to various stimuli is also given for a better understanding of the characteristics of the organ. Included are chapters describing specific diseases and animal models of the diseases. Examples and illustrations are presented for surgical applications. For instance, patients with intractable vertigo of inner-ear origin require surgical treatment and the application of a laser to the vestibular labyrinth, described in detail. With its generous use of color photographs, this book is an excellent reference text for all doctors and trainees in the field of otolaryngology.
  • Part 1. Structure and Function of Mortalin / Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer / Renu Wadhwa and Sunil C. Kaul -- Mortalin's Machinery / Custer C. Deocaris, Sunil C. Kaul and Renu Wadhwa -- The Role of Mortalin in Iron Homeostasis / Wen-I Luo and James A. Cowan -- Functional Characteristics of Mortalin / Walter A. Baseler, Tara L. Croston and John M. Hollander -- Part 2. Mortalin in Evolution2 Deocaris / Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis / Marie Le Pécheur, Geneviève Morrow and Robert M. Tanguay -- Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes / Charles W. Walker, Ben Low and S. Anne Böttger -- Mortalin and Stem Cells: A Study from Planarians / Renata Batistoni -- Part 3. Mortalin in Health and Disease / Mortalin in Cell Protection from Immune Attack / Moran Saar, Oren Moskovich and Zvi Fishelson -- Mortalin in Neurological Diseases / Jinghua Jin, Jing Zhang, Travis J. Cook and Jake G. Hoekstra -- Loss of Mortalin Function in Parkinson's Disease-Supporting the Mitochondrial Pathway of Neurodegeneration / Lena F. Burbulla and Rejko Krüger -- Hsp75/mortalin and Protection from Ischemic Brain Injury / Robin E. White, Yi-Bing Ouyang and Rona G. Giffard -- Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders / Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa and Ram K. Mishra -- Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis / Alberto J. L. Macario, Francesco Cappello and Everly Conway de Macario -- Part 4. Mortalin and Cancer / Many Faces of Mortalin and Tid1 / Ohad Iosefson and Abdussalam Azem -- Mortalin: A Positive Regulator of Centrosome Duplication and Amplification / Masayuki Kanai and Kenji Fukasawa -- Mortalin Expression in Normal and Neoplastic Tissues / Angheliki Nomikos, Sinclair R. Dundas and Graeme I. Murray -- Mortalin-p53 Interaction as a Target for Liver Cancer Therapy / Wen-Jing Lu, Nikki P. Lee, Renu Wadhwa and John M. Luk -- Mortalin Targeting Gadgets for Cancer Therapy / Chae-Ok Yun and Renu Wadhwa -- Part 5. Mortalin Based Technologies / Cell Internalizing Anti-Mortalin Antibody for Generation of Illuminating MSCs for Long-Term In vitro and In vivo Tracking / Toshimasa Uemura, Masanori Nishi, Sunil C. Kaul and Renu Wadhwa -- Mortalin Staining Pattern as a Reporter for Cell Based Anti-Cancer Drug Screening / Ran Gao, Zeenia Kaul, Tomoko Yaguchi and Renu Wadhwa -- Cell Internalizing Anti-mortalin Antibody as a Nanocarrier / Zeenia Kaul, Tomoko Yaguchi, Renu Wadhwa and Sunil C. Kaul.
  • pt. 1. Congenital cardiovascular malformations.
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    "Courageous, insightful and candid thoughts on malady and mortality from one of our most celebrated writers"--Provided by the publisher.
  • Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devotedto the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
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  • Ideal for chairside use by the entire dental team, Mosby's Dental Drug Reference, 11th Edition, provides the current, concise, dental-specific drug information you need at the point of care. More than 850 drug monographs make it easy to find indications and dosages, contraindications, interactions, side effects, serious reactions, and dental considerations. A companion website adds regular drug updates, a full-color pill atlas, printable patient education handouts, reference tables, and more. More than 850 drug monographs offer the vital dental-specific drug information you need.Drug information with relevant patient and family education guidelines in each monograph emphasize oral health, prevention, and treatment from the dental hygiene perspective.Durable and pocket sized, a succinct and organized format makes this guide ideal for chairside use. Bulleted lists provide quick and easy access to general and specific dental-related information in each monograph. .Primers on therapeutic management of common diseases and on medically compromised patients offer key foundational information relevant to the treatment of all patients.New monographs, FDA updates, a color pill atlas, images of common pathologic conditions, patient education handouts, quick-reference guides, and more are available online to help keep this guide compact and user-friendly.
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  • Section 1. Overview and occupational therapy process -- section 2. Occupational performance and the performance areas : evaluation and intervention -- section 3. Performance skills and client factors : evaluation and intervention -- section 4. The occupational therapy process : implementation of interventions -- section 5. Intervention applications.
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    The History and interviewing process -- Cultural awareness -- Examination techniques and equipment -- Mental status -- Growth and measurement -- Nutrition -- Assessment of pain -- Skin, hair, and nails -- Lymphatic system -- Head and neck -- Eyes -- Ears, nose, and throat -- Chest and lungs -- Heart -- Blood vessels -- Breasts and axillae -- Abdomen -- Female genitalia -- Male genitalia -- Anus, rectum, and prostate -- Musculoskeletal system -- Neurologic system -- Sports participation and evaluation -- Putting it all together -- Taking the next steps: critical thinking -- Recording information -- Emergency or life-threatening situations.
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  • Designing a mosquito sampling programme -- Sampling the egg population -- Sampling the larval population -- Sampling the emerging adult population -- Sampling the adult resting population -- Sampling adults by animal bait catches and by animal-baited traps -- Blood-feeding and its epidemiological significance -- Sampling adults with non-attractant traps -- Sampling adults with light-traps -- Sampling adults with carbon dioxide traps -- Sampling adults with visual attraction traps, sound traps, and other miscellaneous attraction traps -- Estimation of the mortalities of the immature stages -- Methods of age-grading adults and estimation of adult survival rates -- Estimating the size of the adult population -- Measuring adult dispersal -- Experimental hut techniques -- Indices of association and species diversity indices.
  • Japanese Encephalitis (JE), a mosquito borne disease, is the leading cause of viral encephalitis in 14 Asian countries due to its epidemic potential, high case fatality rate and increased possibility of lifelong disability in patients who recover from this dreadful disease. In spite of seriousness of the disease, still only few books are available for ready reference. Hence, this book will be useful for students, entomologists, paramedical staff and vector control managers in public health.Of the thousand suspected JE deaths in India annually, more than 75% is contributed by Northern India wherein disease transmission failed to be explained based on entomological evidence due to inadequate mosquito surveillance tool used in determining JE vector density. In order to overcome the above problem, Dr Bina Pani Das, the author of this book, developed "BPD hop cage method", a simple, cost effective, and operationally feasible surveillance tool specially designed to capture predominantly day resting adult Cx. tritaeniorhynchus mosquitoes, the principal JE vector species in the country from land and aquatic vegetation.
  • "Established since 1968 as a classic pediatric cardiology text, this edition uses new technology to bring the most sought after information in the most concise, effective manner. This eighth edition is reduced from the two-volume work into a concise, easy-to-use single volume moving all but key references to the online component. Leading international experts describe state-of-the-art diagnostic and interventional techniques for treatment of young patients with congenital and acquired heart diseases and for adult survivors of congenital heart disease"-- Provided by publisher.
  • v. 1. Structure and function of the cardiovascular system ; Diagnostic methods ; Electrophysiology ; Therapeutic methods ; Pediatric cardiac intensive care ; From the gene to the neonate ; Congenital cardiovascular malformations -- v. 2. Congenital cardiovascular malformations [cont'd.] ; Diseases of the endocardium, myocardium, and pericardium ; Pulmonary vascular disease ; The young adult with congenital heart disease ; Other special problems and issues.
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  • This book fills the gap in knowledge of cultural and social issues relating to pregnancy, childbirth, and motherhood. The book is based on a study which explored how women and their partners in Melbourne, Australia, understood and resolved postnatal depression (PND). The central argument was the significance of support before and after the birth for women's emotional well-being. Thirty-three women who experienced PND were individually interviewed, and eighteen partners were either individually interviewed or attended a focus group. Women were asked to draw their experience of PND and its resolution; these drawings were powerful representations of their lived experience and are included in this book. The book highlights the struggles women faced and the amount of support they received from health professionals, family and friends before and after the birth. The partners provided valuable insights about the support they provided to women, their understanding of PND, as well as their own emotional well-being after the birth. This book offers much more than previous books: it provides the stories of both the women and their partners and a research method (drawings) that is new in the health and social sciences.The insights presented in this book can be used to inform and develop programs to identify women who are particularly vulnerable to experiencing PND, or to improve the treatment of the illness to assist other families in their recovery.
  • Despite the importance of regaining social roles during recovery from mental illness, the intersection between motherhood and serious mental illness is often overlooked. This book aims to rectify that neglect. A series of introductory chapters describing current research and services available to mothers with serious mental illness are followed by personal accounts of clients reflecting on their parenting experiences. One goal of the book is to provide clinicians with information on this seldom addressed topic, which they can then use to help patients who are struggling with questions and barriers in their attempts to parent. The inclusion of personal accounts of mothers on issues such as stigma, fears, and discrimination in the context of parenting with a mental illness is intended to promote the message of mental illness recovery to a larger audience as well. Finally, it is hoped that this handbook will help inspire more research on mothers with mental illness and the creation of more services tailored to their needs.
  • New motion-preserving devices are revolutionizing spine surgery, but the learning curve for these operations is steep, and great attention must be given to patient and device selection and the perfect execution of each procedure. In this text, global leaders in this area discuss the advantages and disadvantages of the full range of non-fusion technologies and present the step-by-step, richly illustrated operative guidance needed to achieve optimal outcomes. Three hours of surgical video on DVD demonstrate how to perform key procedures.
  • Introduction: motivational aspects of prejudice and racism / Cynthia Willis-Esqueda -- Social cognition, ethnic identity, and ethnic specific strategies for coping with threat due to prejudice and discrimination / Amado M. Padilla -- New directions in adversive racism research: persistence and pervasiveness / John F. Dovidio and Samuel L. Gaertner -- The role of race and racial prejudice in recognizing other people / John C. Brigham -- Addressing contemporary racism: the common ingroup identity model / Samuel L. Gaertner and John F. Dovidio.
  • This title draws upon research on the drug widely believed to form the basis of tobacco use and dependence, nicotine. When discussing drug addiction and dependence, an increasing number of scientists are using the concepts of motivation and related constructs and their applications in modifying behavior.
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    Introduction to motor neuron disease -- History of the recognition of motor neuron disease -- Nomenclature & classification of motor neuron disease -- Clinical anatomy, physiology and pathology of motor neuron disease -- Clinical features of motor neuron disease -- Frontotemporal dysfunction and dementia in amyotrophic lateral sclerosis -- Laboratory tests for motor neuron disease -- Biomarkers for motor neuron disease -- Imaging in motor neuron disease -- Diagnostic criteria for motor neuron disease -- Differential diagnosis of motor neuron disease -- Motor neuron disease progression -- Epidemiology of amyotrophic lateral sclerosis -- Genetics of amyotrophic lateral sclerosis and frontotemporal dementia -- Genome-wide approaches to identify amyotrophic lateral sclerosis-associated genes -- Pathology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration -- Convergence and divergence in amyotrophic lateral sclerosis syndrome: genetics, molecular pathways and molecular mechanisms: -- Immunologic aspects of amyotrophic lateral sclerosis -- Cyanobacteria, amyotrophic lateral sclerosis, and the BMAA hypothesis -- Animal models of adult motor neuron disease -- Multidisciplinary clinics and practice parameters and guidelines -- Allied health and other providers -- Respiratory assessment and management -- Nutritional assessment and management -- Communication assessment and management -- Psychological and psychiatric assessment and management -- Symptoms and management -- Intimacy, sexuality and pregnancy -- Quality of life -- Caregiver issues -- End of life care -- Costs of amyotrophic lateral sclerosis care -- Clinical trial designs in amyotrophic lateral sclerosis -- Stem cell therapy for motor neuron disease.
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    Motor unit number estimations (MUNEs): past, present, and future -- Change in excitability of motor axons modifies statistical MUNE results -- Biological basis for motor unit number estimation through Bayesian statistical analysis of the stimulus-response curve -- Bayesian analysis of the stimulus-response curve -- Results of Bayesian statistical analysis in normal and ALS subjects -- CMAP scan -- Physiological considerations, harware and software requirements for stimulating single motor nerve fibers -- Improving the accuracy of the multiple point stimulation technique -- Incremental stimulation MUNE: automation with global path search and alternation pattern recognition -- Motor unit estimation with high-densit surface EMG: principles and implications -- Decomposition-enhanced spike triggered averaging MUNE: validity, reliability, and impact of contraction force -- Motor unit number estimation in the upper trapezius muscle -- Statistical motor unit number estimation and ALS trials: the effect of motor unit instability -- Motor neuron disorders: novel electrophysiologic approach (MUFDEC protocol) -- Motor unit number estimation (MUNE) in diseases of the motor neuron: utility and comparative analysis in a multimodal biomarker study -- Motor unit number estimation in asymptomatic familial amyotrophic lateral sclerosis -- Detection of pre-clinical motor unit loss in familial amyotrophic lateral sclerosis -- Motor unit number estimates, quantitative motor unit analysis and clinical outcome measures in amyotrophic lateral sclerosis -- Reduction in the motor unit number estimate (MUNE) after cerebral infarction -- Prospective 15-year study of neuromuscular function in a cohort of patients with prior poliomyelitis -- Recent MUNE studies in animal models of motor neuron disease -- Development and use of the incremental twitch subtraction MUNE method in mice -- Issues and expectations for EMG decomposition -- Challenges in computerized MUAP analysis -- Decision support for QEMG -- Optimizing and standardizing quantitative EMG -- Comparison of three quantitative motor unit analysis algorithms -- Cloud interference pattern analysis (IPA) in thoracic paraspinal muscles in motor neuron disease -- Anal sphincter motor unit potential (MUP) differences between sides, between rest and voluntary contraction, and between MUP analysis programs in normal subjects.
  • Genomic insulators in transgenic animals -- German mouse clinic: running an open access platform -- Nature and nurture: impacts on mouse phenotypes and translational research -- Informatics of high-throughput mouse phenotyping: EUMODIC and beyond -- Experimental tumour models in mice -- Exploration of MMP function in mouse models of angiogenesis -- Tumor-stroma interactions: focus on fibroblasts -- Experimental procedures to assay invasion-associated activities of primary cultured fibroblasts -- Systemic instigation: a mouse model to study breast cancer as a systemic disease.
  • Chapter 1. Introduction to the Research Process -- Chapter 2. Mice -- Chapter 3. Tests of Mouse Behavior -- Chapter 4. Designs -- Chapter 5. Sample Size -- Chapter 6. Ethics Approval -- Chapter 7. Logistics -- Chapter 8. Getting Ready for Testing -- Chapter 9. Prelude to Data Analysis -- Chapter 10. Domains and Test Batteries -- Chapter 11. Motivating Mice -- Chapter 12. Qualities of Behavioral Tests -- Chapter 13. Task Refinement and Standardization -- Chapter 14. Video Tracking -- Chapter 15. The Laboratory Environment.
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  • Post-transcriptional Control of Gene Expression During Mouse Oogenesis / Hugh J. Clarke -- Polarity and Asymmetry During Mouse Oogenesis and Oocyte Maturation / Malgorzata Kloc, Rafik M. Ghobrial, Ewa Borsuk and Jacek Z. Kubiak -- Chromatin Structure and ATRX Function in Mouse Oocytes / Rabindranath De La Fuente, Claudia Baumann and Maria M. Viveiros -- Cyclin B in Mouse Oocytes and Embryos: Importance for Human Reproduction and Aneuploidy / Zbigniew Polański, Hayden Homer and Jacek Z. Kubiak -- Src Protein Kinases in Mouse and Rat Oocytes and Embryos / Mattan Levi, Lihi Ninio-Mani and Ruth Shalgi -- Gradual Meiosis-To-Mitosis Transition in the Early Mouse Embryo / Aurélien Courtois and Takashi Hiiragi -- Maternal Control of Mouse Preimplantation Development / Wenjing Zheng and Kui Liu -- Preimplantation Mouse Embryo: Developmental Fate and Potency of Blastomeres / Aneta Suwińska -- Creation of Trophectoderm, the First Epithelium, in Mouse Preimplantation Development / Yusuke Marikawa and Vernadeth B. Alarcon -- Cell Lineage Allocation Within the Inner Cell Mass of the Mouse Blastocyst / Panagiotis Xenopoulos, Minjung Kang and Anna-Katerina Hadjantonakis -- Formation of Distinct Cell Types in the Mouse Blastocyst / Samantha A. Morris and Magdalena Zernicka-Goetz -- Cell Movements in the Egg Cylinder Stage Mouse Embryo / Bradley Joyce and Shankar Srinivas -- Balancing the Dose in the Mouse / Mary E. Donohoe -- Mouse Oviduct Development / C. Allison Stewart and Richard R. Behringer -- Cell Lineages, Growth and Repair of the Mouse Heart / Fabienne Lescroart and Sigolène M. Meilhac -- Cellular Reprogramming During Mouse Development / Zoë D. Burke, Gabriela Miron-Buchacra and David Tosh -- Differentiation of Definitive Endoderm from Mouse Embryonic Stem Cells / Peter T. W. Kim and Christopher J. Ong -- Mouse and Human Pluripotent Stem Cells and the Means of Their Myogenic Differentiation / I. Grabowska, K. Archacka, A. M. Czerwinska, M. Krupa and M. A. Ciemerych -- Stem Cells and Corneal Epithelial Maintenance: Insights from the Mouse and Other Animal Models / Richard L. Mort, Panagiotis Douvaras, Steven D. Morley, Natalie Dorà and Robert E. Hill, et al. -- Mouse-Induced Pluripotent Stem Cells / Hui Zhang and Ying Jin -- Aging in the Mouse and Perspectives of Rejuvenation Through Induced Pluripotent Stem Cells (iPSCs) / Ken-ichi Isobe, Zhao Cheng, Sachiko Ito and Naomi Nishio.
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    Collection of peripheral blood -- Counting red blood cells, platelets, and viable nucleated white blood cells -- Protocol 1 determination of percent red cell volume (hematocrit) -- Protocol 2 methodology to determine a red blood cell count using a hemacytometer -- Protocol 3 methodology to determine a platelet cell count using a unopette and a hemacytometer -- Protocol 4 methodology to determine a white blood cell count and viability using a hemacytometer -- Peripheral blood films and cytospin preparations -- Protocol 5 washing slides in preparation for microscopic examination of peripheral blood and bone marrow -- Protocol 6 preparation of a peripheral blood film -- Protocol 7 fixing, staining, and mounting a peripheral blood film -- Protocol 8 preparation of a peripheral blood suspension for cytospin analysis -- Cell differential assessments of peripheral blood films -- Preparation of bone marrow for microscopic examination -- Protocol 9 bone marrow biopsy of the mouse -- Protocol 10 preparation of a bone marrow brush smear -- Protocol 11 preparation of a bone marrow suspension for cytospin analysis -- Cell differential assessments of bone marrow.
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    v. 1. History, wild mice, and genetics - - v. 2. Diseases - - v. 3. Normative biology, husbandry, and models - - v. 4. Immunology
  • Transgenic Mouse Models -- Pulmonary Antigen Presenting Cells: Isolation, Purification, and Culture -- Evaluation of T Cell Function in Allergic Disease -- Evaluating B-Cells: From Bone Marrow Precursors to Antibody Producing Cells -- Protocols for Identifying, Enumerating and Assessing Mouse Eosinophils -- Evaluation of Classical, Alternative, and Regulatory Functions of Bone Marrow-Derived Macrophages -- Applications of Mouse Airway Epithelial Cell Culture for Asthma Research -- Isolation and Characterization of Mast Cells in Mouse Models of Allergic Diseases -- Purifying and Measuring Immunoglobulin E (IgE) and Anti-IgE -- Protocols for the Induction and Evaluation of Systemic Anaphylaxis in Mice -- Contact Hypersensitivity Models in Mice -- Induction of Allergic Rhinitis in Mice -- Induction of Allergic Airway Disease Using House Dust Mite Allergen -- An Inhalation Model of Allergic Fungal Asthma: Aspergillus fumigatus-Induced Inflammation and Remodeling in Allergic Airways Disease -- PAMPs and DAMPs in Allergy Exacerbation Models -- Assessment of Airway Hyperresponsiveness in Mouse Models of Allergic Lung Disease Using Detailed Measurements of Respiratory Mechanics -- Bilateral Vagotomy as a Tool for Determining Autonomic Involvement in Airway Responses in Mouse Models of Asthma -- Clara Epithelial Cell Depletion in the Lung -- A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma -- Assessment of Airway Hyperresponsiveness in Murine Tracheal Rings -- Use of the Cockroach Antigen Model of Acute Asthma to Determine the Immunomodulatory Role of Early Exposure to Gastrointestinal Infection -- Expression Profiling to Identify Candidate Genes Associated with Allergic Phenotypes -- Flow Cytometric Methods for the Assessment of Allergic Disease -- Generation of Bone Marrow and Fetal Liver Chimeric Mice.
  • The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
  • Mouse nervous system 2012
    The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlases A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness.
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  • A Brief Introduction to Movement Disorders / Steven J. Frucht -- Acute Parkinsonism / Hubert H. Fernandez and Joseph H. Friedman -- Parkinsonism-Hyperpyrexia Syndrome in Parkinson's Disease / Daniel E. Huddleston and Stewart A. Factor -- Neuroleptic Malignant Syndrome / Stanley N. Caroff, Stephan C. Mann, Kenneth A. Sullivan and E. Cabrina Campbell -- Malignant Catatonia / Stephan C. Mann, Stanley N. Caroff, Henry R. Bleier and E. Cabrina Campbell -- Psychosis and Parkinson's Disease / Christina L. Vaughan and Jennifer G. Goldman -- Abductor Paresis in Shy-Drager Disease / Eiji Isozaki -- Movement Disorder Emergencies of the Upper Aerodigestive Tract / Lesley Childs, Scott Rickert, Boris Bentsianov, Ajay Chitkara and Anthony Cultrara, et al. -- Dystonic Storm / Melissa J. Nirenberg and Blair Ford -- Pseudodystonic Emergencies / Jong-Min Kim and Beom S. Jeon -- Tardive and Neuroleptic-Induced Emergencies / Paul E. Greene and Steven J. Frucht -- Hemiballism-Hemichorea / Ronald B. Postuma and Anthony E. Lang -- Sydenham's Chorea, PANDAS, and Other Post-streptococcal Neurological Disorders / Roser Pons -- Emergencies in Huntington's Disease / Kathleen M. Shannon -- Acute Spinal Rigidity / P. D. Thompson -- Tic Emergencies / Vanessa K. Hinson and Christopher G. Goetz -- Malignant Phonic Tics / Joseph Jankovic -- Serotonin Syndrome / Mark Forrest Gordon and Adena N. Leder -- Risks and Dangers from Hyperekplexia and Other Startle Disorders / Frederick Andermann and Eva Andermann -- Perioperative Emergencies Associated with Deep Brain Stimulation / Takashi Morishita, Adam P. Burdick and Michael S. Okun -- Psychogenic Movement Disorders / Daniel Schneider and Daniel T. Williams -- Anti-NMDA Receptor Encephalitis and Other Autoimmune and Paraneoplastic Movement Disorders / Jessica Panzer and Josep Dalmau -- Wilson's Disease / George J. Brewer -- Dopa-Responsive Dystonia / Yoshiaki Furukawa, Mark Guttman, Shinichiro Nakamura and Stephen J. Kish -- Whipple's Disease / Eoin Mulroy, John Lynch and Tim Lynch -- Driving Risk in Patients with Movement Disorders / Ergun Y. Uc -- Genetics and Genetic Counseling Related Issues / Martha A. Nance -- Suicide Risk in Parkinson's Disease / Valerie Voon.
  • This book covers recent developments and possible pitfalls in the diagnosis of genetic movement disorders and related conditions. It is divided into three sections: technical and scientific aspects; clinical aspects with guidance towards work-up; and ethical and legal aspects of genetic testing in a clinical and research setting. The first section includes chapters on genetic analysis and counselling with critical discussion of potential problems when interpreting the results. Clinical chapters summarize genetic forms of movement disorders including parkinsonism, tics and dystonia with algorithms for hands-on daily practice. Related conditions such as RLS, ataxias and dementias are also covered. Finally, chapters on ethical and legal aspects of genetic testing are included. Movement Disorder Genetics is aimed at clinicians and scientists working in the field of movement disorders and related conditions. .
  • History of surgery for movement disorders / Philip L. Gildenberg -- Rational for movement disorder surgery / Cameron C. McIntyre ... [et al.] -- Setting up a practice / Brian Harris Kopell, Kenneth Baker, Nicholas M. Boulis -- Selection of patients, centers and disorders / Leo Verhagen Metman -- Preparation for surgery / Ron L. Alterman, Michele Tagliati -- Anesthesia for movement disorder surgery / Robert E. Gross, Klaus Mewes, Ghaleb Ghani -- Stereotactic surgery with microelectrode recordings / Diane Sierens ... [et al.] -- Stereotactic surgery without microelectrode recording / Marwan I. Hariz, Nathalie Vayssière -- Implantation of multiple electrode and robotic techniques / Alim Louis Benabid ... [et al.] -- Frameless functional stereotactic approaches / Jaimie M. Henderson -- Deep brain stimulation for tremor / Jorge L. Eller, Kim J. Burchiel -- Deep brain stimulation for dystonia / Brian Harris Kopell, Craig I. Horenstein, Ali R. Rezai -- Deep brain stimulation programming / Erwin B. Montgomery, Jr. -- Avoiding complications and correcting errors / Philip A. Starr -- Efficacy and complications of deep brain stimulation for movement disorders / Erich O. Richter, Clement Hamani, Andres M. Lozano -- Gamma knife / Ronald F. Young -- Future directions in movement disorders surgery / Shivanand P. Lad ... [et al.].
  • Experts in the field, Drs. Singer, Mink, Gilbert, and Jankovic, fill the gap in the market by offering the only comprehensive text devoted solely to the diagnoses and treatment of all pediatric movement disorders. Discussions of common and rare disorders such as movements that occur in sleep and psychogenic movement disorders and the latest advances and developments in medications keep you apprised of today₂s best practices. Each chapter is accessible, illustrated, stylistically uniform, and carefully referenced, making it easy to access the information you need. This brand-new reference is the ideal resource for the seasoned specialist as well as the non-expert clinician. Best of all, Expert Consult functionality gives you convenient access to the full text online - fully searchable, a downloadable image library, and enhanced visual guidance with narrated, diagnostic videos at ₅ Includes online access to the complete contents of the book, fully searchable, including all of the book₂s illustrations, 58 narrated videos of actual patients and their disorders, and abstracts to Medline at Discusses neurobiology, classification, diagnostic evaluation, and treatment, making this a one-stop-shop for all you need to know to diagnose and treat any child with any movement disorder.
  • Ch. 1. Introduction -- Ch. 2. Parkinsonism: Parkinson's disease -- Ch. 3. Parkinsonism: Parkinson's plus -- Ch. 4. Surgery for Parkinson's disease -- Ch. 5. Tremor -- Ch. 6. Dystonia -- Ch. 7. Chorea -- Ch. 8. Tics and related disorders -- Ch. 9. Myoclonus -- Ch. 10. Movement disorders during sleep -- Ch. 11. Drug-induced movement disorders -- Ch. 12. Paediatric movement disorders -- Ch. 13. Psychogenic movement disorders -- Ch. 14. Other dyskinesias.
  • "This book focuses on extrapyramidal signs and symptoms of all types of dementia, and addresses the issue of the artificial boundary between dementias and Parkinsonism, which represent the two most common symptoms found in degenerative central nervous system diseases. In Movement Disorders in Dementias, movement disorder specialists from around the world write on topics generally restricted to dementia experts. Important motor issues related to either medication in demented patients (drug-induced movement disorders) or manifestations common to all forms of dementia, regardless of underlying cause (gait disorders, falls, fear of falling), is followed by analysis of the relationship between motor and cognitive symptoms, from their common pathogenesis to specific medical treatments. Movement Disorders in Dementias is aimed at general neurologists, dementia specialists, movement disorders specialists, neuropsychologists and geriatricians."--Publisher's website.
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  • "This multi-authored, well-organized monograph is a must read for any physician involved in the care of patients with Mmoyamoya disease. It is moderately short and very easy to read but still provides a state-of-the-art review of the disease with updated aspects, especially in its etiology and pathogenesis, epidemiology, and long-term results"--Provided by publisher.
  • MR enterography 2014
    In recent years, there has been huge interest in developing new methods that offer improved accuracy for the detection of small bowel pathology, and in particular for the assessment of inflammatory bowel diseases (IBD). Cross-sectional imaging, such as CT and MR, has advantages over traditional barium fluoroscopic techniques in terms of direct visualization of the bowel wall and improved visualization of extraluminal findings and complications. This means a complete change in the diagnostic approach to the patient with IBD: from analysis of the bowel surface to direct evaluation of parietal alterations and assessment of peri- and extraintestinal involvement. The ideal imaging test is reproducible, well tolerated by patients and, above all, free of ionizing radiation. MR enterography, currently performed only in a few reference centers, meets these criteria and offers accurate diagnosis, particularly in respect of the wide spectrum of intra- and extraintestinal complications of IBD. This book provides a thorough overview of the indications, techniques, diagnostic advantages, and limitations of MR enterography. Particular attention is paid to patient preparation in relation to the particular study type and to the potential advantages of the most up-to-date MR studies in specific cases, e.g., allergy or renal failure. A separate chapter is devoted to MR of perianal region for the detection and staging of perianal fistula, a common complication in patients with Crohn's disease. Numerous high-quality illustrations are included and help to ensure that the book will be a valuable source of information for every radiologist involved in abdominal MR imaging.
  • "Presented by a team of experts in the speciality, this book provides a comprehensive overview of MRI of the abdomen and pelvis in adult and pediatric patients. The book's organization by organ or organ system allows the reader to approach the field one topic at a time. Each chapter lists the indications for MRI, describes in detail the specific imaging technique, and shows the MRI appearance of normal anatomy and pathologic entities."--Back cover.
  • Introduction -- The Developing Human Brain: Differences from Adult Brain -- Magnetic Resonance Spectroscopy: Basics -- Metabolites of Proton Magnetic Resonance Spectroscopy and Normal Age-Dependent Changes -- Challenges in Pediatric Magnetic Resonance Imaging -- Pathologies -- Magnetic Resonance Spectroscopy of Pediatric Brain Tumors -- Diffuse Intrinsic Pontine Gliomas -- Traumatic Brain Injury and Concussion -- Proton Magnetic Resonance Spectroscopy: Applications in Neonatal Medicine -- Proton Magnetic Resonance Spectroscopy: Application in Non-Accidental Trauma -- Leukodystrophies -- Metabolic Disorders -- Phenylketonuria -- Infection and Encephalitis -- Hepatic Encephalopathy in Children -- Magnetic Resonance Spectroscopy in Epilepsy -- ¹H Magnetic Resonance Spectroscopy of the Brain During Adolescence: Normal Brain Development and Neuropsychiatric Disorders -- Magnetic Resonance Spectroscopy Studies of Autistic Spectrum Disorders -- Magnetic Resonance Spectroscopy Studies of Attention Deficit Hyperactivity Disorder -- Magnetic Resonance Spectroscopy of the Fetal Brain -- MRS of the Neonatal Brain: Abnormal Development and Neonatal Pathology.
  • MRC applied psychology Unit 2003
    Wellcome Trust
    "This transcript considers the origins and impact of the MRC Applied Psychology Unit's work from 1944 to 1998."
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    Production of Net Magnetization -- Concepts of Magnetic Resonance -- Relaxation -- Principles of Magnetic Resonance Imaging: part 1 -- Principles of Magnetic Resonance Imaging: part 2 -- Pulse Sequences -- Measurement Parameters and Image Contrast -- Signal Suppression Techniques -- Artifacts -- Motion Artifact Reduction Techniques -- Magnetic Resonance Angiography -- Advanced Imaging Applications -- Magnetic Resonance Spectroscopy -- Instrumentation -- Contrast Agents -- Safety -- Clinical Applications.
  • Essentials of MRI physics and pulse sequences / Shivani Ahlawat, Rick W. Obray, Douglas P. Beall, John D. Reeder, John A. Carrino, and Laura M. Fayad -- Normal spine MRI anatomy / Swati Deshmukh, John A. Carrino, J. Dana Dunleavy, and A. Jay Khanna -- Common clinical and correlative pain generators of the cervical and lumbosacral spine / Josemaria Paterno, Chad M. Silverberg, A. Jay Khanna, and Aneesh K. Singla -- A systematic approach to the review of spine MRI studies / A. Jay Khanna -- The occipitocervical junction / Colin M. Haines, A. Jay Khanna, John A. Carrino, Shih-Chun David Lin, and Joseph R. O'Brien -- The cervical spine / Lukas P. Zebala, Jacob M. Buchowski, Aditya Daftary, Joseph R. O'Brien, John A. Carrino, and A. Jay Khanna -- The lumbar and thoracic spine / Gbolahan O. Okubadejo, Aditya Daftary, Jacob M. Buchowski, John A. Carrino, and A. Jay Khanna -- Tumors of the spine / Daniel M. Sciubba, Patricia L. Zadnik, Bruce A. Wasserman, and Ziya L. Gokaslan -- MRI of the pediatric spine / A. Jay Khanna, Bruce A. Wasserman, and Paul D. Sponseller -- Advanced techniques in spine MRI / Joseph P. Gjolaj and John A. Carrino -- Correlation of MRI with other imaging studies / Shivani Ahlawat, Uma Srikumaran, A. Jay Khanna, and Laura M. Fayad -- MRI safety considerations for the referring clinician / Monica D. Watkins and Bruce A. Wasserman.
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    MR : what's the attraction? -- Early daze : your first week in MR -- Seeing is believing : introduction to image contrast -- The devil's in the detail : pixels, matrices, and slices -- What you set is what you get : basic image optimization -- Improving your image : how to avoid artefacts -- Spaced out : spatial encoding -- Getting in tune : resonance and relaxation -- Let's talk technical : MR equipment -- But is it safe? : bio-effects -- Ghosts in the machine : quality control -- Acronyms anonymous : a guide to the pulse sequence jungle -- Go with the flow : MR angiography -- A heart to heart discussion : cardiac MRI -- It's not just squiggles : in-vivo spectroscopy -- To BOLDly go : new frontiers -- The parallel universe : parallel imaging and novel acquisition techniques -- Appendix: Maths revision.
  • MRI Handbook presents a concise review of the physical principles underlying magnetic resonance imaging (MRI), explaining MR physics, patient positioning, and protocols in an easy-to-read format. The first five chapters of the book introduce the reader to the basics of MR imaging, including the relaxation concept, MR pulse sequences, and MR imaging parameters and options. The second part of the book (chapters 6-11) uses extensive illustrations, images, and protocol tables to explain tips and tricks to achieve optimal MR image quality while ensuring patient safety. Individual chapters are devoted to each major anatomic region, including the central nervous, musculoskeletal, and cardiovascular systems. By using annotated MR images and examples of patient positions used during scanning correlated with sample protocols and parameters, MRI Handbook is a practical resource for imaging professionals to use in the course of their daily practice as well as for students to learn the basic concepts of MR imaging.
  • MRI in epilepsy 2013
    MRI can play an important role in identifying and localizing epileptogenic foci. This book aims to provide the clinical and imaging information required in order to decide whether an MRI scan is appropriate and whether it is likely to be sufficient to detect a lesion. The first part of the book presents background information on epilepsy patients and explains how to perform an MRI examination. Detailed attention is paid to functional MRI and post-processing, and the examination of subcategories of patients is also discussed. The second part of the book then documents the MRI findings obtained.
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  • MRI in psychiatry 2014
    This is the first comprehensive textbook on the use of MRI in psychiatry covering imaging techniques, brain systems and a review of findings in different psychiatric disorders. The book is divided into three sections, the first of which covers in detail all the major MRI-based methodological approaches available today, including fMRI, EEG-fMRI, DTI, and MR spectroscopy. In addition, the role of MRI in imaging genetics and combined brain stimulation and imaging is carefully explained. The second section provides an overview of the different brain systems that are relevant for psychiatric disorders, including the systems for perception, emotion, cognition, and reward. The final part of the book presents the MRI findings that are obtained in all the major psychiatric disorders using the previously discussed techniques. Numerous carefully chosen images support the informative text, making this an ideal reference work for all practitioners and trainees with an interest in this flourishing field.
  • This book on radiology of musculoskeletal diseases is an aid for the radiologist evaluating problems of the bones, joints, and muscles. Comprehensive differential diagnostic tables are juxtaposed with excellent illustrations from all radiologic modalities. Along with the differential diagnoses, helpful hints for further evaluation or narrowing the diagnosis are provided.
  • Patient preparation: magnetic resonance imaging techniques -- Cardiovascular anatomy and atlas of MR normal anatomy -- MRI sequential segmental analysis and identification of anomalies -- Anomalous systemic and pulmonary venous connections -- Aortic arch anomalies, tracheal compression and stenosis -- Other aortic malformations -- Anomalies of the right ventricular outflow tract and pulmonary arteries -- Postoperative evaluation
  • This richly illustrated case-based atlas thoroughly depicts the role of MR imaging in the assessment of patients presenting with pain due to degenerative disease of the spine and will serve as an excellent guide to differential diagnosis. Importantly, generic radicular compression is the main reason for the painful symptomatology in only a limited number of cases, and this book illustrates and emphasizes how various anatomic elements of the spine can be responsible. The imaging features of a range of disorders involving both the anterior and posterior elements of the spine are described, including active inflammatory osteochondrosis, atypical herniated discs, facet joint disorders, spondylolysis, and degenerative-inflammatory changes of the spinal ligaments and posterior perispinal muscles. Each example is supported by clinical data, and a series of unusual cases are also presented. MR study protocols include T2-weighted sequences with fat saturation and contrast-enhanced T1-weighted sequences with fat saturation to allow better visualization or highlighting of various inflammatory changes in the spine. Radiologists, neuroradiologists, neurosurgeons, orthopedists, and rehabilitation physicians will all find this atlas a valuable asset in their practice.
  • Based on the experience of two Italian referral centers, the book depicts the characteristic findings obtained when using MR imaging to study the male and female pelvis including the obstetric applications. Each chapter provides a comprehensive account of the use of the imaging technique of examination, including the most recent advances in MR imaging, the anatomy and MR possibilities in the identification, characterization and staging of the different pelvic diseases highlighting its diagnostic possibilities. The advances in fetal MRI, representing the cutting edge of pelvic MR imaging, will also be depicted. The text is complemented by numerous illustrations, as well as clinical cases that make this a very practice-oriented work, presenting the role of diagnostic imaging in every-day clinical activity. The volume will prove an invaluable guide for both residents and professionals with core interest in gynecology, obstetrics and urology.
  • MRI of the gastrointestinal tract: coils, sequences, techniques -- MRI of the gastrointestinal tract at high-field strength -- Contrast media for MRI of the gastrointestinal tract -- Dynamic contrast-enhanced and diffusion-weighted MRI of the gastrointestinal tract -- MRI of the esophagus and stomach -- MRI of the upper GI tract motility -- MRI of the duodenum -- MRI of the small bowel: enterography -- MRI of the small bowel: enteroclysis -- MRI of the small bowel: clinical role -- MRI of the colon (MR colonography): technique -- MRI of the colon (colonography): results -- MRI of the rectum -- MRI of bowel motility -- MRI of the peritoneum -- MRI of adhesions and small bowel obstruction -- MRI of acute conditions of the gastrointestinal tract -- MRI of the pelvic floor -- MRI of the anus.
  • This book is divided into chapters that cover MRI of all structures of the knee joint in the order that is usually used in practice ? cruciate ligaments, collateral ligaments, menisci, cartilage, subchondral bone, patella, synovia, muscles and tendons, arteries, veins and bones. With the aid of numerous images, each chapter provides comprehensive descriptions of the anatomy, the normal MR appearance, pathological MR findings, and postoperative MRI appearance. A text box at the end of each chapter clearly describes how the MRI report should be compiled and identifies what should be included when reporting on specific lesions. The book will be an ideal guide for radiologists and will also be relevant for orthopaedic surgeons, rheumatologists, and physiotherapists.
  • MRI of the lung 2009
  • Basic principles and terminology of magnetic resonance imaging / Robert A. Pooley, Joel P. Felmlee, and Richard L. Morin -- Interpretation of magnetic resonance images / Mark S. Collins and Richard L. Ehman -- General technical considerations in musculoskeletal MRI / Thomas H. Berquist -- The temporomandibular joint / Thomas H. Berquist -- Spine / Robert Witte and John Lane -- Pelvis, hips, and thigh / Thomas H. Berquist -- Knee / Thomas H. Berquist -- Foot, ankle, and calf / Thomas H. Berquist -- Shoulder, arm / Thomas H. Berquist and Jeffrey J. Peterson -- Elbow and forearm / Thomas H. Berquist and Laura W. Bancroft -- Hand and wrist / Thomas H. Berquist -- Musculoskeletal neoplasms / Mark J. Kransdorf and Thomas H. Berquist -- Musculoskeletal infection / Thomas H. Berquist and Daniel F. Broderick -- Diffuse marrow diseases / James B. Vogler, III and William A. Murphy, Jr. -- Miscellaneous conditions / Thomas H. Berquist -- Clinical spectroscopy / Thomas H. Berquist.
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  • Pt. 1. Basic concepts -- pt. 2. Limitations of conventional MRI -- pt. 3. Advanced solutions -- pt. 4. The future.
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  • mTOR inhibitors in cancer treatment / Leonidas C. Platanias -- Overview and mechanism of action of mTOR inhibitors / Stéphane Oudard -- mTOR inhibitors in renal cell carcinoma / Piotr J. Wysocki -- mTOR inhibitors in hepatocellular carcinoma / Gerhard Treiber & Thomas Wex -- mTOR inhibitors in ovarian cancer / Susana M. Campos -- mTOR inhibitors in breast cancer / Ingrid A. Mayer -- mTOR inhibitors in Hodgkin's and non-Hodgkin's lymphomas / Sonali M. Smith.
  • mTORC1: a signalling integration node involved in cell growth -- The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions -- mTOR signaling in angiogenesis -- mTORC1 signaling and hypoxia -- mTOR signaling in glioblastoma: lessions learned from bench to bedside -- mTOR and cancer therapy: general principles -- mTOR and cancer therapy: clinical development and novel prospects -- Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer -- Downstream targets of mTORC1 -- Downstream of mTOR: translational and control of cancer -- Genome-wide analysis of translational control -- Translational control of cancer: implications for targeted therapy -- Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex.
  • Mucins and cancer 2013
    Future Med
    Mucins and cancer / Joyce Taylor-Papadimitriou & Joy M. Burchell -- Introduction to mucins in cancer / Michael A. McGuckin -- Changes in mucin-type O-linked glycosylation in cancer / Joy M. Burchell & Joyce Taylor-Papadimitriou -- Mucins as biomarkers in cancer / Kowa Chen, Ola Blixt & Hans H. Wandall -- Signaling from membrane mucins / Tze Wei Poh & Sandra J. Gendler -- MUC4 and membrane receptors in cancer / Kermit L. Carraway & Coralie A. Carothers Carraway -- MUC16, alias CA125 and ovarian cancer / Evangelia-Ourania Fourkala, Aleksandra Gentry-Maharaj & Usha Menon -- Mucins in metastasis / Sylvain Julien -- How mucins shape antigen-presenting cells to modify immune responses / Sandra J. van Vliet & Yvette van Kooyk -- MUC1 as a therapeutic target in cancer / Jean-Marc Limacher & Bruce Acres -- Index.
  • The role of mucosal immunity in protection against viral diseases / Vandana Madkan, Karan Sra, and Stephen K. Tyring -- Anogenital mucosal immunology and virology / Anthony Simmons -- Gastrointestinal mucosal immunology / David A. Bland, Carlos A. Barrera, and Victor E. Reyes -- Virology of the gastrointestinal tract / Richard L. Ward ... [et al.] -- Oral manifestations of viral diseases / Denis P. Lynch -- Common respiratory viruses and pulmonary mucosal immunology / David B. Huang -- Ophthalmic manifestations of viral diseases / Steven Yeh and Mitchell P. Weikert.
  • In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
  • Mucosal immunology. 3rd ed. 2005
  • Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
  • Introduction -- Basic properties of Müller cells -- Müller cell gliosis -- Müller cells in the healthy retina -- Retinal Development -- Müller cells as 'light cables' -- Soft Müller cells as shock absorbers and axon paths -- 'Metabolic symbiosis' -- Neurotransmitter recycling -- Retinal K+ homeostasis -- Retinal water homeostasis -- Other interactions -- Müller cells in the diseased retina -- Retinal detachment -- Diabetic retinopathy -- Macular edema -- Proliferative retinopathies -- Ischemia-reperfusion -- Hepatic retinopathy -- Retinoschisis -- Retinitis pigmentosa and support of neuronal survival -- Future directions -- Index.
  • v.2 (2011) Springer
  • Multi-detector CT imaging v. 1-2, 2014
    v. 2, 2014 CRCnetBASE
    [Vol. 1] Principles, head, neck, and vascular systems -- [vol. 2] Abdomen, pelvis and CAD applications.
  • Stroke is one of the leading causes of death in the world, resulting mostly from the sudden ruptures of atherosclerosis carotid plaques. Understanding why and how plaque develops and ruptures requires a multi-disciplinary approach such as radiology, biomedical engineering, medical physics, software engineering, hardware engineering, pathological and histological imaging. Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment presents a new dimension of understanding Atherosclerosis in 2D and 3D. This book presents work on plaque stress analysis in order to provide a general framework of computational modeling with atherosclerosis plaques. New algorithms based on 3D and 4D Ultrasound are presented to assess the atherosclerotic disease as well as very recent advances in plaque multimodality image fusion analysis. The goal of Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment is to fuse information obtained from different 3D medical image modalities, such as 3D US, CT and MRI, providing the medical doctor with some sort of augmented reality information about the atherosclerotic plaque in order to improve the accuracy of the diagnosis. Analysis of the plaque dynamics along the cardiac cycle is also a valuable indicator for plaque instability assessment and therefore for risk stratification. 4D Ultrasound, a sequence of 3D reconstructions of the region of interest along the time, can be used for this dynamic analysis. Multimodality Image Fusion is a very appealing approach because it puts together the best characteristics of each modality, such as, the high temporal resolution of US and the high spatial resolutions of MRI and CT.
  • Neuroendocrine effects of developmental PCB exposure, with particular reference to hypothalamic gene expression -- The kisspeptin system as putative target for endocrine disruption of puberty and reproductive health -- Effects of prenatal exposure to endocrine disrupters on cerebral cortex development -- Endocrine disruption of the thyroid and its consequences in development -- Neural progenitors are direct targets of xenoestrogens in zebrafish -- Exposure to environmental chemicals as a risk factor for diabetes development -- Contribution of endocrine disrupting chemicals to the obesity epidemic: consequences of developmental exposure -- Fetal and adult exposure to bisphenol-A as a contributing factor in the etiology of the metabolic syndrome -- Bisphenol A in the gut: another break in the wall? -- Adverse trends of male reproductive health in two nordic countries indicate environmental problems -- Origin of testicular dysgenesis syndrome disorders in the masculinization programming window: relevance to final testis size (=sperm production) -- Index.
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    T-cell receptor / Jose M. Rojo, Raquel Bello and Pilar Portolés -- B-cell receptor / Randall J. Brezski and John G. Monroe -- FC receptors / Maree S. Powell and P. Mark Hogarth -- Natural killer cell receptors / Roberto Biassoni -- Platelet glycoprotein VI / Stephanie M. Jung and Masaaki Moroi -- Clustering models / Wolfgang W.A. Schamel and Michael Reth -- Segregation models / Elaine P. Dopfer ... [et al.] -- Kinetic proofreading model / Byron Goldstein ... [et al.] -- Serial triggering model / Jacob Rachmilewitz -- Conformational model / Ruth M. Risueño, Angel R. Ortiz, and Balbino Alarcón -- Permissive geometry model / Susana Minguet and Wolfgang W.A. Schamel -- Signaling chain homooligomerization (SCHOOL) model / Alexander B. Sigalov -- Visualization of cell-cell interaction contacts : synapses and kinapses / Michael L. Dustin -- Visualization of protein interactions in living cells / Tomasz Zal -- Immunogenicity in peptide-immunotherapy : from self/nonself to similar/dissimilar sequences / Darja Kanduc -- Therapeutic application of transmembrane T and natural killer cell receptor peptides / Nicholas Manolios ... [et al.] -- FC receptor targeting in the treatment of allergy, autoimmune diseases and cancer / Akira Nakamura, Tomohiro Kubo and Toshiyuki Takai -- Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease / Joseph R. Podojil, Danielle M. Turley, and Stephen D. Miller -- MHC and MHC-like molecules : structural perspectives on the design of molecular vaccines / Vasso Apostolopoulos, Eliada Lazoura and Minmin Yu -- SCHOOL model and new targeting strategies / Alexander B. Sigalov -- Immune receptor signaling, aging and autoimmunity / Anis Larbi, Tamas Fülöp and Graham Pawelec -- Viral pathogenesis, modulation of immune receptor signaling and treatment / Walter M. Kim and Alexander B. Sigalov.
  • This book describes in detail the multidisciplinary management of obesity, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical exercise, psychological issues, nutritional strategies, pharmacological options, and bariatric surgery. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of obesity, which has rapidly become a major public health problem.
  • Part I. General Allergy. Prevalence of Allergic Diseases in China / Huan Qian, Min Zheng -- Mechanism of Type I Hypersensitivity / Cheng Zhou -- Multidisciplinary Approaches to Allergy Prevention / Luud J.W.J. Gilissen, Zhong-Shan Gao, Zhi Chen -- Part II. Allergenic Sources and Allergens. Overview of Allergen Sources in China / Zhao-Wei Yang, Zhong-Shan Gao, Ying-Tao Ma [and others] -- Allergen Protein Families and Cross-Reactivity / Luud J.W.J. Gilissen, Zhong-Shan Gao -- Seafood Allergens in China and Anti-allergenic Property of Seaweeds / Zhen-Xing Li, Hong Lin -- Food Allergen Epitopes / Hong-Bing Chen, Jin-Yan Gao -- Recombinant Allergens and Applications / Ying-Tao Ma, Zhao-Wei Yang, Zhong-Shan Gao -- Part III. Diagnosis. The CREATE Project: Development of Certified Reference Materials for Allergenic Products and Validation of Methods for Their Quantification / R. van Ree, M.D. Chapman, F. Ferreira [and others] -- Diagnosis of Skin Allergy Diseases / Huan Qian, Min Zheng -- Novel Approaches for the In-Vitro Diagnosis of Type I Allergies / Margrit Fooke -- Influence of Food Processing, Digestion and the Food Matrix on Allergenicity & Cellular Measures of Allergenicity / Y.M. Vissers, H.J. Wichers, H.F.J. Savelkoul -- Part IV. Therapies and Pharmacy. Immunotherapy of Asthma: From Basic Research to Clinical Practices / Hui-Ying Wang, Hua-Hao Shen -- Pharmacotherapy in Common Allergic Diseases / Erina M. Lin -- Immunotherapy in Allergic Skin Disease / Hao Cheng -- Traditional Chinese Medicine for Treating Food Allergy and Associated Eczema: From Research to Practice Perspective / Xiu-Min Li -- Immunomodulation by Food / Ingrid van der Meer, Jurriaan Mes, Amrah Weijn, Harry Wichers -- Prospective Studies on Mite (Dermatophagoides farinae) Allergen Immunotherapy in China / Ting-Huan Wen -- The Influence of Pollen Concentration on the Dispension of Antihistaminics and Corticosteroids to Hay Fever Patients / Arnold J.H. van Vliet, Hilde Tobi -- Part V. Hypoallergenic Products. In Search of Hypoallergenic Birch Trees: Characterization of PR-10 Genes from Eight Betula Species and Detection of Bet v 1 Isoforms in Birch Pollen Using a Combined Genomics- Proteomics Approach / M.J.M. Smulders, Martijn F. Schenk, Luud J.W.J. Gilissen -- Hypoallergenic Soybean, from Genes to Cultivar / Rong-Xia Guan, Xu-Qian Fang, Ru-Zhen Chang, Li-Juan Qiu -- Fruit Allergy and Genetic and Genomic Tools to Select Hypoallergenic Fruit Cultivars / Zhong-Shan Gao, Zhao-Wei Yang, Luud Gilissen -- Creating Hypoallergenic Crops through Genetic Modification / Xing-Jun Wang, Han Xia, Shuan-Tao Liu [and others] -- Acceptance of Natural and Genetically Modified Hypoallergenic Apples by Consumers with an Oral Allergy Syndrome (OAS) / I.M. van der Meer, M.F. Schenk, A.R.H. Fischer [and others] -- Cow's Milk Allergens and Technologies to Control Allergenicity / Yong-Kang Luo, Guan-Hao Bu -- Part VI Environment, Hygiene and Societal Issues. Prevalence of Asthma and Asthmatic Symptoms in Children in Relation to Environmental Factors --Epidemiological Studies in School Children in Taiyuan, China / Zhuo-Hui Zhao, Zhuan-Hua Wang, Zheng Zhang [and others] -- The Relationship of Food Allergies and Respiratory Allergies in Urban and Rural Chinese Children / Gary W.K. Wong, Yu-Zhi Chen, Jing Li, Nan-Shan Zhong -- Socio-Economic Issues Associated with Food Allergy / L.J. Frewer, J. Voordouw, M.F. Schenk [and others] -- The Association between Helminth Infections and Atopic Diseases / L.A.H. Hermsen.
  • Multidisciplinary Care of Urinary Incontinence - a Handbook for Health Professionals effectively uses a multidisciplinary approach to assist health professionals in their care of patients with urinary incontinence. It is recognized that the best outcomes are achieved by a multidisciplinary team approach especially with regard to complex cases and care of the elderly. This book is written by expert authors from around the world with a wealth of experience in conducting clinics on pelvic floor, aged care voiding dysfunction and neuro-rehabilitation. The text is illustrated throughout and contains case-studies with input and practical tips from the different health disciplines at each point. Each chapter concludes with a list of seminal publications and web-based resources to assist the reader in the clinical environment. Multidisciplinary Care of Urinary Incontinence - a Handbook for Health Professionals is of benefit to medical and allied health disciplines including family physicians, nurses, urologists, gynecologists, physiotherapists, geriatricians, neurologists and rehabilitation specialists.
  • Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such a multidisciplinary approach within a specialized unit involves a variety of specialists, including urologists, oncologists, radiotherapists, radiologists and pathologists. This book describes in detail the advantages of multidisciplinary management of prostate cancer. It opens by explaining the nature of the required multidisciplinary team and the potential benefits of the prostate cancer unit as a structure for the delivery of specialist multidisciplinary care. Epidemiological aspects favoring multidisciplinary management are described and each element of care within the context of the prostate cancer unit is then discussed; also has been described the role of advanced imaging (Multiparametric MRI) in the management of PCa. Early diagnosis, risk classification, treatment decision making, surgery, radiotherapy, medical therapies and health care support are all fully considered. This book will be informative and enlightening for all who are involved in the management of patients with prostate cancer.
  • This book is intended as the equivalent of the Swiss Army knife for all members of colorectal cancer (CRC) multidisciplinary teams and those training in the fields of CRC management. It describes how to organize the team and explains the basic principles within the different disciplines involved in the treatment and care of CRC patients. Important, up-to-date knowledge is provided on visualization techniques, surgery, oncological treatment, palliation, and pathology, with special focus on controversies and aspects of interest to all team members. Care has been taken to ensure that each specialty-specific chapter will be approachable for team members from other specialties or professions, thereby facilitating an effective interdisciplinary approach to teamwork. The authors include leading European doctors and scientists who have influenced the development of the multidisciplinary team concept as well as other aspects of high-quality, individualized treatment of CRC patients.
  • It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.
  • This book provides the practising ophthalmologist and surgeon with up-to-date information on the use of multifocal intraocular lenses to eliminate pseudophakic presbyopia. Guidance is provided on types and models of intraocular lens, indications, selection of patients, implantation, neuroadaptation, and complications and their avoidance. A key goal is to enable the practitioner to select the best lens for the individual patient, taking into account special circumstances. In addition, the results achieved to date with different lenses are analyzed and advice is given on the management of expectations. The authors are acknowledged international experts who draw upon their own experience and the peer-reviewed literature to provide the practitioner with cutting-edge information and evidence-based guidance.
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  • Current methods and their applications for cardiovascular multimodal imaging -- Echocardiography -- Phonocardiography -- Myocardial perfusion single photon emission computed tomography and positron emission tomography -- Coronary angiography -- Cardiac computed tomography -- Cardiac magnetic resonance imaging in ischemic heart disease -- Electrocardiography of ischemic heart disease -- Electrophysiologic mapping -- Nuclear cardiology applied to electrophysiology -- Optical mapping of electrical activity -- Dipolar electrocardiotopography imaging -- Foundations of future methods for cardiovascular multimodal imaging -- Electrocardiographic imaging of epicardial potentials -- Electromechanical modeling applied to cardiac resychronization therapy -- Computational cardiac electrophysiology: modeling tissue and organ -- Cardiac simulation for education: the electrocardiogram according to ECGSIM -- Graphical analysis of heart rate patterns to access cardiac autonomic function -- Development of the heart, with particular reference to the cardiac conduction tissues -- Cardiovascular multimodal imaging in key clincial problems -- Congenital heart disease: atrioventricular septal defect -- Right ventricular cardiomyopathies -- Ischemic heart disease -- Acute myocardial infarction -- Diseases of the aorta -- Peripheral vascular disease -- Pulmonary vascular disease -- Atrial fibrillation.
  • Over the last decade, remarkable innovations in transcatheter technologies have led to the rapid development of minimally invasive therapies that have challenged conventional treatment. Amongst these, none is as remarkable as transcatheter aortic valve replacement (TAVR). An archetype of bench-to-bedside medicine, the origins of TAVR spanned the expertise and vision of clinicians, engineers, researchers and imagers. With increasing numbers of TAVR procedures and large-scale trials demonstrating an unparalleled reduction in mortality for inoperable patients with severe aortic valvular disease, the theme underpinning the foundation of TAVR that of a multidisciplinary approach to its development persists in its practice. This approach brings together a diverse group of experts to optimize patient outcomes and this extends to the convergence of different types of imaging specialists and modalities to support preparation for and performance and follow-up of TAVR. Multimodality Imaging for Transcatheter Aortic Valve Replacement assembles the very best authorities in the field to create the ultimate resource to address the imaging needs associated with TAVR. It provides the reader with a comprehensive understanding of the pathophysiology of aortic stenosis, the evidence supporting the use of TAVR, and an integrated approach to the indications, procedural aspects and pitfalls of imaging in TAVR. The reader will also gain an insight into which tests are optimal in specific situations and a step-wise method to harvest all the essential information provided with each modality. Thus, this book represents a key resource for all working in the field whether they be in training or practicing physicians, cardiac researchers, cardiac imagers, interventionalists, clinical cardiologists, cardiac surgeons, or any medical professional involved in the management of these patients.
  • Interest in regional anaesthesia has been flourishing for a number of reasons, including in particular the feasibility of ultrasound-guided peripheral nerve blocks. This trend is reflected in the growing popularity of fellowships in regional anaesthesia. The syllabus for such fellowship examinations is vast, and this book aims to provide suitable guidance by presenting typical multiple choice questions with accompanying answers, in detail when necessary. The entire syllabus is covered in four comprehensive sections that address basic principles and equipment, peripheral nerve blocks, central neuraxial blocks, and regional anaesthesia and acute pain. Multiple Choice Questions in Regional Anaesthesia will be especially useful for those preparing for European Society of Regional Anaesthesia diploma examinations or for the regional anaesthesia component of FRCA examinations. It is also highly relevant to equivalent U.S. and Canadian examinations and will be helpful to all who require a self-assessment tool in the subject.
  • A reference suitable for orthopedic surgeons, trauma surgeons, sports medicine fellows, orthopedic surgery residents, physical therapists, physician assistants, and all health professionals who treat traumatic injuries of the knee. Vastly expanded from its first publication, new topics in this edition include: -ACL based multiple ligament knee injury-Mechanical graft tensioning-Fracture dislocations-Articular cartilage restoration-Meniscus transplantation-Extensor mechanism restoration. Hundreds of illustrations and photographs facilitate easy comprehension of the text. Covering everything from anatomy and biomechanics through diagnosis, classification, both non-surgical and surgical management, complications and selected case studies, gives a complete picture of a complex pathologic entity.
  • Multiple myeloma 2011
    Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
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  • Identification of malignant plasma cells by mRNA in situ hybridization / Ross D. Brown and P. Joy Ho -- The SCID-hu myeloma model / Joshua Epstein and Shmuel Yaccoby -- The 5T2MM murine model of multiple myeloma: maintenance and analysis / Karin Vanderkerken ... [et al.] -- Determination of telomerase activity and telomere length / Kai-da Wu and Malcolm A.S. Moore -- Dendritic cell/myeloma hybrid vaccine / Dajing Xia, Tim Chan, and Jim Xiang -- Genetically engineered myeloma cell vaccine / Siguo Hao, Tim Chan, and Jim Xiang -- An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors / Andrew C.W. Zannettino ... [et al.] -- Clonality detection of the expanded T-cell populations in patients with multiple myeloma / Daniel M-Y. Sze -- Detecting mismatch repair defects in myeloma / Mark Velangi ... [et al.] -- Methylation-specific polymerase chain reaction / Oliver Galm and James G. Herman -- Making sense of DNA microarray data / Wei-min Liu, Sunhee K. Ro, and Walter H. Koch. Multiple myeloma: challenges and opportunities / Douglas Joshua, Ross D. Brown, and P. Joy Ho -- Immunophenotyping of plasma cells in multiple myeloma / Gema Mateo Manzanera, Jesús F. San Miguel Izquierdo, and Alberto Orfao de Matos -- Plasma cell labeling index / Philip R. Griepp and Shaji Kumar -- Conventional cytogenetics in myeloma / Lynda J. Campbell -- Multicolor spectral karyotyping in multiple myeloma / Jeffrey R. Sawyer -- Detection of chromosome 13 deletions by fluorescent in situ hybridization / Scott VanWier and Rafael Fonseca -- Comparative genomic hybridization for analysis of changes in DNA copy number in multiple myeloma / Pulivarthi H. Rao -- Southern blotting of IgH rearrangements in B-cell disorders / Edna Yuen and Ross D. Brown -- Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma / Surinder S. Sahota, Mark Townsend, and Freda K. Stevenson -- Identification of clonotypic IgH VDJ sequences in multiple myeloma / Brian J. Taylor ... [et al.] -- Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in myeloma / Mara Compagno ... [et al.] -- Incomplete DJH rearrangements / David González and Ramón Garcia-Sanz ...
  • This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care.
  • In theoretical terms, sex differences in brain and behavior offer the possibility of fascinating scientific studies on a range of molecular phenomena such as DNA methylation, chromatin protein modification, non-coding DNA, resulting in important neuroanatomical and neurochemical effects. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present where they did not really exist, e.g. with respect to mathematics, executive leadership, etc. etc. Under what circumstances do we really care about sex differences in brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men. Prominent examples to be discussed today will include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia. The meeting will end with a consideration of effects of estrogenic hormones on the injured brain, and their roles as protective agents.
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    The spectrum and diagnosis of multiple sclerosis / Orhun H. Kantarci -- The differential diagnosis of multiple sclerosis / Orhun H. Kantarci -- The epidemiology, genetics, environment, and natural history of multiple sclerosis / Orhun H. Kantarci -- The role of magnetic resonance imaging in multiple sclerosis / Istvan Pirko -- Neuropathology : clues to pathogenesis / Moses Rodriguez -- What has immunology taught us about multiple sclerosis? / Moses Rodriguez -- Neural degeneration and potential novel treatments / Moses Rodriguez -- Treatment of acute exacerbations of multiple sclerosis / Istvan Pirko -- Disease-modifying therapies in multiple sclerosis / Istvan Pirko -- Managing symptoms of multiple sclerosis / Orhun H. Kantarci -- Upcoming therapies / Istvan Pirko -- Treatment to promote remyelination / Moses Rodriguez.
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  • Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology.
  • Structure, molecular organization, and function of myelinated axons -- Neuronal concomitants of demyelination -- Multiple sclerosis as a neurodegenerative disease -- Measurement of neuronal changes in the clinical domain -- Cellular and molecular mechanisms of axonal degeneration in multiple sclerosis -- Other aspects of neuronal injury in multiple sclerosis -- Lessons from the peripheral nervous system -- Prognosis, reparative mechanisms, and therapeutic approaches.
  • Signs and symptoms of multiple sclerosis / Stanley van den Noort -- Differential diagnosis, clinical features, and prognosis of multiple sclerosis / Michael J. Olek -- Role of magnetic resonance imaging in the diagnosis and prognosis of multiple sclerosis / Robert Zivadinov and Rohit Bakshi -- Cognitive dysfunction in multiple sclerosis / Darcy Cox and Laura Julian -- Multiple sclerosis, genetics, and autoimmunity / Michael Demetriou -- B-cell immunology in multiple sclerosis / Yufen Qin and Pierre Duquette -- Multiple sclerosis : a case for early treatment / Alex C. Tselis and Omar A. Khan -- Pregnancy and multiple sclerosis / Christina Caon -- Treatment of progressive multiple sclerosis / Norman Wang -- Cyclophosphamide therapy for multiple sclerosis / Derek R. Smith -- Repair and neuroprotective strategies in multiple sclerosis / Fernando Dangond -- Future therapies / Michael J. Olek.
  • The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the "new" MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and-even more-the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that "translation" is real and not just virtual.
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  • "This edited handbook provides a comprehensive resource to inform and guide health and rehabilitation practitioners as they engage in the rehabilitation process with multiple sclerosis patients. The text provides a broad-based perspective on multiple sclerosis, how it influences everyday life, and the strategies that can be employed by rehabilitation practitioners to enable people with MS to fully engage in everyday life. The first section offers an overview of MS basics; the next two sections describe MS rehabilitation to manage impairments and to enhance activity and participation among MS patients; and the final section presents contextual factors that may influence MS rehabilitation efforts"--Provided by publisher.
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    Terminology and disease description -- The framing of multiple sclerosis -- The palsy without a name: suffering with paraplegia, 1395-1868 -- The steps toward a discovery : the early medical reports -- The building blocks of a discovery -- The contribution of J.M. Charcot, 1868 -- The medical reports after Charcot -- Clarifying the pathology : James Dawson -- The journal of a disappointed man -- Experimentation, meetings, reviews, and symposia, 1920-1960 -- Searching for a cause of MS -- Classifying and measuring MS -- The nature of the MS plaque -- Investigations -- Searching for therapy -- Multiple sclerosis and the public: societies, narratives and the media.
  • This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson's disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.
  • 1. Multiplicity problems in clinical trials : a regulatory perspective / Mohammad Huque and Joachim Rèohmel -- 2. Multiple testing methodology / Alex Dmitrienko ... [et al.] -- 3. Multiple testing in dose-response problems / Frank Bretz, Ajit C. Tamhane, and Josâe Pinheiro -- 4. Analysis of multiple endpoints in clinical trials / Ajit C. Tamhane and Alex Dmitrienko -- 5. Gatekeeping procedures in clinical trials / Alex Dmitrienko and Ajit C. Tamhane -- 6. Adaptive designs and confirmatory hypothesis testing / Willi Maurer, Michael Branson, and Martin Posch -- 7. Design and analysis of microarray experiments for pharmacogenomics / Jason C. Hsu ... [et al.].
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    "This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target"--Publisher's description.
  • Is a pear sweeter than a peach? Which of Mona Lisa's hands is crossed over the other? What would the Moonlight Sonata sound like played by a brass band? Although these are questions that appeal to mental imagery in a variety of sensory modalities, mental imagery research has been dominated by visual imagery. With the emergence of a well-established multisensory research community, however, it is time to look at mental imagery in a wider sensory context. Part I of this book provides overviews of unisensory imagery in each sensory modality, including motor imagery, together with discussions of multisensory and cross-modal interactions, synesthesia, imagery in the blind and following brain damage, and methodological considerations. Part II reviews the application of mental imagery research in a range of settings including individual differences, skilled performance such as sports and surgical training, psychopathology and therapy, through to stroke rehabilitation. This combination of comprehensive coverage of the senses with reviews from both theoretical and applied perspectives not only complements the growing multisensory literature but also responds to recent calls for translational research in the multisensory field.
  • Corticocortical connectivity subserving different forms of multisensory convergence / M. Alex Meredith and H. Ruth Clemo -- Computational modeling of multisensory object perception / Constantin Rothkopf, Thomas Weisswange, and Jochen Triesch -- Methodological considerations : electrophysiology of multisensory interactions in humans / Marie-Hélène Giard and Julien Besle -- Cortical oscillations and multisensory interactions in humans / Jochen Kaiser and Marcus J. Naumer -- Multisensory functional magnetic resonance imaging / Marcus J. Naumer ... [et al.] -- Audiovisual temporal integration for complex speech, object-action, animal call, and musical stimuli / Argiro Vatakis and Charles Spence -- Imaging cross-modal influences in auditory cortex / Christoph Kayser, Christopher I. Petkov, and Nikos K. Logothetis -- The default mode of primate vocal communication and its neural correlates / Asif A. Ghazanfar -- Audio-visual perception of everyday natural objects - hemodynamic studies in humans / James W. Lewis -- Single-trial multisensory learning and memory retrieval / Micah M. Murray and Holger F. Sperdin -- Multisensory texture perception / Roberta L. Klatzky and Susan J. Lederman -- Dorsal and ventral cortical pathways for visuo-haptic shape integration revealed using fMRI / Thomas W. James and Sunah Kim -- Visuo-haptic perception of objects and scenes / Fiona N. Newell -- Haptic face processing and its relation to vision / Susan J. Lederman, Roberta L. Klatzky, and Ryo Kitada -- The ontogeny of human multisensory object perception : a constructivist account / David J. Lewkowicz -- Neural development and plasticity of multisensory representations / Mark T. Wallace, Juliane Krueger, and David W. Royal -- Large-scale brain plasticity following blindness and the use of sensory substitution devices / Andreja Bubic, Ella Striem-Amit, and Amir Amedi.
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  • Physical Background of Multi Detector Row Computed Tomography / Thomas Flohr -- Future Developments for MSCT / Patrik Rogalla -- Radiation Exposure and Risk Associated with CT Examinations / Gunnar Brix and Elke A. Nekolla -- Contrast Agent Application and Protocols / Markus S. Juchems -- Imaging Findings of Cirrhotic Liver / Jeong Min Lee, Dong Ho Lee and Jeong-Hee Yoon -- Imaging Findings in Non-Cirrhotic Liver / Daniele Marin and Giuseppe Brancatelli -- Liver and Biliary System: Postoperative Findings / Magaly Zappa, Annie Sibert and Valérie Vilgrain -- Inflammatory Processes in the Liver and Biliary Tract / Wesley C. Chan and Benjamin M. Yeh -- Neoplastic Processes in Biliary System / Tae Kyoung Kim, Korosh Khalili and Hyun-Jung Jang -- Assessment of the Hepatic Vessels with MDCT / Rocio Perez-Johnston, Dipti K. Lenhart, Daniella F. Pinho and Dushyant V. Sahani -- MSCT Imaging of Acute and Chronic Pancreatitis / Shelby Fishback, David H. Kim and Perry J. Pickhardt -- Solid Pancreatic Masses / Alec J. Megibow -- Cystic Pancreatic Masses / A. Oto -- Imaging CT of the Spleen / Giovanni Morana and Christian Cugini -- Imaging of Post Pancreatic Surgery / R. Graziani, S. Mautone, M. C. Ambrosetti, M. Barillari and R. Manfredi, et al. -- Renal Masses / Anno Graser and Ullrich G. Mueller-Lisse -- Adrenal Masses / Julie H. Song and William W. Mayo-Smith -- Inflammatory and Infectious Disease of the Kidney and Urinary Collecting System / Ullrich G. Mueller-Lisse, Ulrike L. Mueller-Lisse, Eva M. Coppenrath and Anno Graser -- MSCT of the Stomach / Sameer Ahmed, Karen M. Horton, Elliot K. Fishman and Pamela T. Johnson -- Small Bowel / Franco Iafrate, Marco Rengo, Paola Lucchesi, Maria Ciolina and Paolo Baldassari, et al. -- MSCT of the Abdomen: Colon, Rectum and CT Colonography / Emanuele Neri, Annalisa Mantarro, Rossella Scandiffio, Pietro Bemi and Lorenzo Faggioni, et al. -- Mesenteric and Retroperitoneal Diseases / Antonella Filippone, Roberta Cianci and Antonio Raffaele Cotroneo -- Imaging Findings in Acute Abdomen / Borut Marincek.
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  • Introduction : Extending the Rasch model / Matthias von Davier, Jürgen Rost, Claus H. Carstensen -- Measurement models as narrative structures / Robert Mislevy, Chun-Wei Huang -- Testing generalized Rasch models / Cees A.W. Glas -- The mixed-coefficients multinomial logit model : a generalized form of the Rasch model / Raymond J. Adams, Margaret L. Wu -- Loglinear multivariate and mixture Rasch models / Henk Kelderman -- Mixture-distribution and HYBRID Rasch models / Matthias von Davier, Kentaro Yamamoto -- Application of the Saltus model to stagelike data : some applications and current developments / Karen Draney, Mark Wilson -- Determination of diagnostic cut-points using stochastically ordered mixed Rasch models / Svend Kreiner -- A HYBRID model for test speededness / Keith A. Boughton, Kentaro Yamamoto -- Multidimensional three-mode Rasch models / Claus H. Carstensen, Jürgen Rost -- (Almost) equivalence between conditional and mixture maximum likelihood estimates for some models of the Rasch type / Anton K. Formann -- Rasch models for longitudinal data / Thorsten Meiser -- The interaction model / Shelby J. Haberman -- Multilevel Rasch models / Akihito Kamata, Yuk Fai Cheong -- Mixed Rasch models for measurement in cognitive psychology / Susan E. Embretson -- Detecting response styles and faking in personality and organizational assessments by mixed Rasch models / Michael Eid, Michael J. Zickar -- Application of multivariate Rasch models in international large-scale educational assessments / Raymond J. Adams, Margaret L. Wu, Claus H. Carstensen -- Studying development via item response models : a wide range of potential uses / Judith Glück, Christiane Spiel -- A comparison of the Rasch model and constrained item response theory models for pertinent psychological test data / Klaus D. Kubinger, Clemens Draxler -- Latent-response Rasch models for strategy shifts in problem-solving processes / Carl P.M. Rijkes, Henk Kelderman -- Validity and objectivity in health-related scales : analysis by graphical loglinear Rasch models / Svend Kreiner, Karl Bang Christensen -- Applications of generalized Rasch models in the sport, exercise, and the motor domains / Gershon Tenenbaum, Bernd Strauss, Dirk Büsch.
  • Machine generated contents note: 2.1. Introduction -- 2.2. Continuous/interval scale data -- 2.3. Simple and multiple linear regression models -- 2.4. Checking assumptions in linear regression models -- 2.5. Likelihood: multiple linear regression -- 2.6. Comparing model likelihoods -- 2.7. Application of a multiple linear regression model -- 2.8. Exercises on linear models -- 3.1. Binary data -- 3.1.1. Introduction -- 3.1.2. Logistic regression -- 3.1.3. Logit and probit transformations -- 3.1.4. General logistic regression -- 3.1.5. Likelihood -- 3.1.6. Example with binary data -- 3.2. Ordinal data -- 3.2.1. Introduction -- 3.2.2. The ordered logit model -- 3.2.3. Dichotomization of ordered categories -- 3.2.4. Likelihood -- 3.2.5. Example with ordered data -- 3.3. Count data -- 3.3.1. Introduction -- 3.3.2. Poisson regression models -- 3.3.3. Likelihood -- 3.3.4. Example with count data -- 3.4. Exercises -- 4.1. Introduction -- 4.2. The linear model 4.3. The binary response model -- 4.4. The Poisson model -- 4.5. Likelihood -- 5.1. Introduction -- 5.2. Linear mixed model -- 5.3. The intraclass correlation coefficient -- 5.4. Parameter estimation by maximum likelihood -- 5.5. Regression with level-two effects -- 5.6. Two-level random intercept models -- 5.7. General two-level models including random intercepts -- 5.8. Likelihood -- 5.9. Residuals -- 5.10. Checking assumptions in mixed models -- 5.11. Comparing model likelihoods -- 5.12. Application of a two-level linear model -- 5.13. Two-level growth models -- 5.13.1. A two-level repeated measures model -- 5.13.2. A linear growth model -- 5.13.3. A quadratic growth model -- 5.14. Likelihood -- 5.15. Example using linear growth models -- 5.16. Exercises using mixed models for continuous/interval scale data -- 6.1. Introduction -- 6.2. The two-level logistic model -- 6.3. General two-level logistic models -- 6.4. Intraclass correlation coefficient -- 6.5. Likelihood -- 6.6. Example using binary data -- 6.7. Exercises using mixed models for binary data 7.1. Introduction -- 7.2. The two-level ordered logit model -- 7.3. Likelihood -- 7.4. Example using mixed models for ordered data -- 7.5. Exercises using mixed models for ordinal data -- 8.1. Introduction -- 8.2. The two-level Poisson model -- 8.3. Likelihood -- 8.4. Example using mixed models for count data -- 8.5. Exercises using mixed models for count data -- 9.1. Introduction -- 9.2. The mixed linear model -- 9.3. The mixed binary response model -- 9.4. The mixed Poisson model -- 9.5. Likelihood -- 10.1. Introduction -- 10.2. Three-level random intercept models -- 10.3. Three-level generalized linear models -- 10.4. Linear models -- 10.5. Binary response models -- 10.6. Likelihood -- 10.7. Example using three-level generalized linear models -- 10.8. Exercises using three-level generalized linear mixed models -- 11.1. Introduction -- 11.2. Multivariate two-level generalized linear model -- 11.3. Bivariate Poisson model: example -- 11.4. Bivariate ordered response model: example -- 11.5. Bivariate linear-probit model: example -- 11.6. Multivariate two-level generalized linear model likelihood 11.7. Exercises using multivariate generalized linear mixed models -- 12.1. Introduction -- 12.1.1. Left censoring -- 12.1.2. Right censoring -- 12.1.3. Time-varying explanatory variables -- 12.1.4. Competing risks -- 12.2. Duration data in discrete time -- 12.2.1. Single-level models for duration data -- 12.2.2. Two-level models for duration data -- 12.2.3. Three-level models for duration data -- 12.3. Renewal data -- 12.3.1. Introduction -- 12.3.2. Example: renewal models -- 12.4. Competing risk data -- 12.4.1. Introduction -- 12.4.2. Likelihood -- 12.4.3. Example: competing risk data -- 12.5. Exercises using renewal and competing risks models -- 13.1. Introduction -- 13.2. Mover-stayer model -- 13.3. Likelihood incorporating the mover-stayer model -- 13.4. Example 1: stayers within count data -- 13.5. Example 2: stayers within binary data -- 13.6. Exercises: stayers -- 14.1. Introduction to key issues: heterogeneity, state dependence and non-stationarity -- 14.2. Example -- 14.3. Random effects models -- 14.4. Initial conditions problem -- 14.5. Initial treatment 14.6. Example: depression data -- 14.7. Classical conditional analysis -- 14.8. Classical conditional model: example -- 14.9. Conditioning on initial response but allowing random effect uol to be dependent on z3 -- 14.10. Wooldridge conditional model: example -- 14.11. Modelling the initial conditions -- 14.12. Same random effect in the initial response and subsequent response models with a common scale parameter -- 14.13. Joint analysis with a common random effect: example -- 14.14. Same random effect in models of the initial response and subsequent responses but with different scale parameters -- 14.15. Joint analysis with a common random effect (different scale parameters): example -- 14.16. Different random effects in models of the initial response and subsequent responses -- 14.17. Different random effects: example -- 14.18. Embedding the Wooldridge approach in joint models for the initial response and subsequent responses -- 14.19. Joint model incorporating the Wooldridge approach: example -- 14.20. Other link functions -- 14.21. Exercises using models incorporating initial conditions/state dependence in binary data 15.1. Introduction -- 15.2. Fixed effects treatment of the two-level linear model -- 15.3. Dummy variable specification of the fixed effects model -- 15.4. Empirical comparison of two-level fixed effects and random effects estimators -- 15.5. Implicit fixed effects estimator -- 15.6. Random effects models -- 15.7. Comparing two-level fixed effects and random effects models -- 15.8. Fixed effects treatment of the three-level linear model -- 15.9. Exercises comparing fixed effects and random effects -- A.1. SabreR installation -- A.2. SabreR commands -- A.2.1. The arguments of the SabreR object -- A.2.2. The anatomy of a SabreR command file -- A.3. Quadrature -- A.3.1. Standard Gaussian quadrature -- A.3.2. Performance of Gaussian quadrature -- A.3.3. Adaptive quadrature -- A.4. Estimation -- A.4.1. Maximizing the log likelihood of random effects models -- A.5. Fixed effects linear models -- A.6. Endogenous and exogenous variables -- B.1. Getting started with R -- B.1.1. Preliminaries -- B.1.1.1. Working with R in interactive mode -- B.1.1.2. Basic functions -- B.1.1.3. Getting help B.1.1.4. Stopping R -- B.1.2. Creating and manipulating data -- B.1.2.1. Vectors and lists -- B.1.2.2. Vectors -- B.1.2.3. Vector operations -- B.1.2.4. Lists -- B.1.2.5. Data frames -- B.1.3. Session management -- B.1.3.1. Managing objects -- B.1.3.2. Attaching and detaching objects -- B.1.3.3. Serialization -- B.1.3.4. R scripts -- B.1.3.5. Batch processing -- B.1.4. R packages -- B.1.4.1. Loading a package into R -- B.1.4.2. Installing a package for use in R -- B.1.4.3. R and Statistics -- B.2. Data preparation for SabreR -- B.2.1. Creation of dummy variables -- B.2.2. Missing values -- B.2.3. Creating lagged response covariate data.
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  • A highly illustrated, practical book covering the obstetric and surgical procedures used in intrapartum care, including commonly used procedures such as assisted vaginal delivery (forceps and vacuum delivery) and more rare techniques such as major vessel ligation and embolization and internal podalic version. The authors take a step-by-step approach to each technique and includes 'tips' and 'pointers' that only an experienced obstetrician would be able to describe. The book is enlivened by the inclusion of short, relevant 'historical highlights'- readers should find these enlightening and entertaining, providing a link with the original Munro Kerr text. Focuses on the intrapartum aspects of obstetric practice - the focus of medico-legal and clinical audit attention. Highly illustrated to show techniques in detailOffers tips and advice to the trainee. Emphasis on practical matters - a step-by-step approachIncludes historical boxes to enliven and entertain.
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    Civilization's martyr -- The Road to Marrakesh -- Europeans and Jews -- A Doctor in Marrakesh -- False starts and false reports -- March 19, 1907 -- In Morocco, no one dies without a reason -- Negotiations -- The Crisis of the month -- Remains of the day.
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    Typhus, lice, war and disinfection -- Decline of German medicine: from euthanasia to murder, delousing and deception, radical treatment and extermination -- Jewish doctors face formidable challenges, struggle to conceal typhus and save lives -- SS doctors, pharmaceutical companies, vaccines, drugs and inhuman experimentation, pseudo science -- The Red Cross fails in its humanitarian vision -- The Evolution of germ warfare: from bodies to germ bombs: putting science ahead of humanitarianism -- Appendices.
  • This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
  • Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel's Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases.
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  • Muscarinic receptor pharmacology and signaling -- Overview of muscarinic receptor subtypes -- Structure-function studies of muscarinic acetylcholine receptors -- Polymorphisms in human muscarinic receptor subtype genes -- Muscarinic receptor trafficking -- Physiological role of G-protein coupled receptor phosphorylation -- Novel muscarinic receptor mutant mouse models -- Muscarinic receptors in the CNS -- Muscarinic receptor pharmacology and circuitry for the modulation of cognition -- Muscarinic agonists and antagonists in schizophrenia -- Muscarinic pain pharmacology: realizing the promise of novel anagesics by overcoming old challenges -- Muscarinic modulation of striatal function and circuitry -- Muscarinic receptors in brain stem and mesopontine cholinergic arousal functions -- Muscarinic receptors in autonomic effector organs -- Muscarinic receptor agonists and antagonists: effects on ocular function -- Muscarinic receptor agonists and antagonists: effects on cardiovascular function -- Muscarinic receptor antagonists: effects on pulmonary function -- Muscarinic agonists and antagonists: effects on gastrointestinal function -- Muscarinic agonists and antagonists: effets on the urinary bladder -- Muscarinic receptors and mediation of hormonal effects of acetylcholine -- Muscarinic receptor agonists and antagonists: effects on inflammation and immunity -- Muscarinic receptor agonists and antagonists: effects on keratinocyte functions -- Muscarinic receptor agonists and antagonists: effects on cancer -- Activation of muscarinic receptors by non-neuronal acetylcholine.
  • The Procedure of Muscle Biopsy -- Histological and Histochemical Stains and Reactions -- Normal Muscle -- Histological and Histochemical changes -- Ultrastructural Changes -- Immunohistochemistry and Immunoblotting -- How to Read A Biopsy -- Classification of Neuromuscular Disorders -- Neurogenic Disorders -- Muscular Dystrophies and Allied Disorders I: Duchenne and Becker Muscular Dystrophy -- Muscular Dystrophies and Allied Disorders II: Limb-Girdle Muscular Dystrophies -- Muscular Dystrophies and Allied Disorders III: Congenital Muscular Dystrophies and Associated Disorders -- Muscular Dystrophies and Allied Disorders IV: Emery-Dreifuss Muscular Dystrophy and Similar Syndromes -- Muscular Dystrophies and Allied Disorders V: Facioscapulohumeral, Myotonic and Oculopharyngeal Muscular Dystrophies -- Myopathies with Vacuoles -- Metabolic Myopathies I: Glycogenoses and Lysosomal Myopathies -- Metabolic Myopathies II: Lipid-Related Disorders and Mitochondrial Myopathies -- Myopathies Associated with Systemic Disorders and Ageing -- Ion Channel Disorders -- Myasthenic Syndromes -- Inflammatory Myopathies -- Toxic and Drug-Induced Myopathies -- Appendix 2: Useful Websites.
  • An introduction to muscle development in drosophila / Helen Sink -- The muscle pattern of drosophila / Volker Hartenstein -- Mesoderm formation in the drosophila embryo / Noriko Wakabayashi-Ito and Y. Tony Ip -- Development of the cardiac musculature / Rolf Bodmer -- Development of the somatic gonad and fat bodies / Mark Van Doren -- Development of the larval visceral musculature / Hsiu-Hsiang Lee, Stephane Zaffran and Manfred Frasch -- Development of the larval somatic musculature / Ana Carmena and Mary Baylies -- Muscle morphogenesis: the process of embryonic myoblast fusion / Susan M. Abmayr and Kiranmai S. Kocherlakota -- Muscle attachment sites-where migrating muscles meet their match / Talila Volk -- Neuromuscular development: connectivity and plasticity / Louise Nicholson and Haig Keshishian -- Metamorphosis and the formation of the adult musculature / Devkanya Dutta and K. VijayRaghavan -- Molecular basis of muscle structure / Jim O. Vigoreaux -- Whole genome approaches to studying drosophila muscle development / Eileen E.M. Furlong -- Comparison of muscle development in drosophila and vertebrates / Michael V. Taylor.
  • Muscle gene therapy 2010
  • Muscle metabolism 2002
    Perspectives / Eleazar Shafrir -- I. Insulin Signaling -- 1. Overview: Tyrosine Kinase Signaling in Insulin Action / Martin G. Myers, Jr. -- 2. Defects in Early Insulin Signaling in Skeletal Muscle / M. Dodson Michael and C. Ronald Kahn -- 3. Defects in Intermediate Insulin Signaling in Skeletal Muscle: Phosphatidylinositol (PI) 3-kinase and Glucose Transport / Francesco Giorgino -- II. Glucose Transport -- 4. Glucose Transport in Muscle / John O. Holloszy and Lorraine A. Nolte -- 5. The GLUT4 Compartments of Skeletal Muscle / Toolsie Ramlal, Peter Tong, Tony Lam, Romel Somwar, Maureen Charron and Amira Klip -- III. Substrate Utilization -- 6. Adverse Metabolic Consequences of Hyperglycemia ("Glucose Toxicity"): Implications for the Pathogenesis of Diabetes Mellitus / Donald A. McClain -- 7. Cellular Mediators of Glucose-Induced Autoregulation of Hexose Transport / Evgenia Alpert, Hanan Totary and Shlomo Sasson -- 8. Physiological Adaptations in Glucose Utilization of Skeletal Muscle / Julian M.R. Mathoo and Mladen Vranic -- 9. Fatty Acids and Muscle Insulin Resistance / Edward W. Kraegen, Gregory J. Cooney, Jiming Ye, Alison L. Thompson and Stuart M. Furler -- 10. Role of AMP Kinase and Malonyl CoA in Exercise-stimulated Skeletal Muscle Metabolism and Insulin Action / David J. Dean and Neil B. Ruderman -- IV. Transgenic and Genetic Models -- 11. The Use of Mouse Transgenic and Homologous Recombination.
  • Part 1. Myofascial pain syndrome -- Myofascial Pain Syndrome / Robert D. Gerwin -- Morphology of Myofascial Trigger Points: What Does a Trigger Point Look Like? / Siegfried Mense -- Introduction / Siegfried Mense and Robert D. Gerwin -- Part 2. Fibromyalgia syndrome -- Fibromyalgia Syndrome: Clinical Aspects and Management / Emma Guymer and Geoffrey O. Littlejohn -- Gender, Genetics, and Other Risk Factors Increasing Vulnerability to Fibromyalgia / Geoffrey O. Littlejohn -- Part 3. Other muscle pain syndromes -- Low Back Pain of Muscular Origin / Robert D. Gerwin -- Masticatory Muscle Pain / Sandro Palla and Mauro Farella -- Inflammatory Myopathies / Ingrid E. Lundberg and Li Alemo Munters -- Whiplash Injury, Muscle Pain and Motor Dysfunction / Jan Dommerholt -- Brain Imaging of Muscle Pain / Sandra Kamping and Herta Flor.
  • Introduction / Siegfried Mense and Robert D. Gerwin -- Functional anatomy of muscle : muscle, nociceptors, and afferent fibers / Siegfried Mense -- Peripheral mechanisms of muscle pain : response behavior of muscle nociceptors and factors eliciting local muscle pain / Siegfried Mense -- Central nervous mechanisms of muscle pain : ascending pathways, central sensitization, and pain-modulating systems / Siegfried Mense -- Referral of musculoskeletal pain / Thomas Graven-Nielsen and Siegfried Mense -- Increased muscle tone as a cause of muscle pain / Siegfried Mense and Alfonse T. Masi -- Reorganized motor control due to muscle pain / Thomas Graven-Nielsen and Lars Arendt-Nielsen.
  • Especially prepared for the international audience, the English language edition of this highly successful handbook describes Professional Applied Kinesiology muscle testing procedures. A departure from the classic understanding of muscle testing for weakness and rehabilitation, these procedures can be used for detecting more subtle, functional abnormalities. Included within the chapters are stretch tests and post-isometric relaxation procedures for the hypertonic, shortened muscle. Muscle anatomy and physiology are briefly recapped in order to enhance reader comprehension. The Muscle Testing Handbook describes testing procedures for almost 100 individual muscles in a unique, quick reference, template approach. In close collaboration with Dr. Garten, the German edition has been adapted for the English-language audience by Dr. Shafer, an American chiropractic colleague. This book is ideal for use by manual therapists, physiotherapists, osteopaths, chiropractors, sports scientists and neurology department staff worldwide. Clearly describes modern muscle test procedures The individual aspects of each muscle are easily compared by the use of well-illustrated templated descriptions A double-page spread design allows the reader a rapid, at-a-glance access to essential information Muscle anatomy and function are succinctly recapped in order to facilitate a complete understanding of the relevance and applicability of the individual test Classic Applied Kinesiology muscle tests for detecting functional abnormalities are well described along with stretch testing and post-isometric relaxation procedures for hypertonic, shortened muscles The importance of postural analysis for the assessment of specific muscle dysfunction is discussed and plainly described Illustrates painful spondylogenic reflex points (areas) for each muscle The role of distal acupuncture points and tendinomuscular meridians in maintaining normal muscle and muscle chain function are noted in accompanying diagrams The most commonly found trigger points, their referred pain patterns and relationship to nearby acupuncture points are clearly illustrated for each muscle Perfect for use in orthopaedics, neurology, general medicine, physiotherapy, chiropractic and osteopathy.
  • 2012 ClinicalKey
  • Chapter 1. Introduction and Aims -- Chapter 2. Methodology and Material -- Chapter 3. Muscles of Non-Osteichthyan Vertebrates -- Chapter 4. Head and Neck Muscles of Actinopterygians and Basal Sarcopterygians -- Chapter 5. From Sarcopterygian Fish to Modern Humans -- Chapter 6. Head and Neck Muscles of Amphibians -- Chapter 7. Head and Neck Muscles of Reptiles -- Chapter 8. Pectoral and Pectoral Fin Muscles of Actinopterygian and Sarcopterygian Fishes -- Chapter 9. From Sarcopterygian Fish to Modern Humans -- Chapter 10. Pectoral and Forelimb Muscles of Limbed Amphibians and Reptiles -- Chapter 11. General Comments.
  • Muscular dystrophies 2011
    Overview of the muscular dystrophies / A.A. Amato and R.C. Griggs -- Dystrophinopathies / L.A. Morrison -- Sarcoglycanopathies / J. Kirschner and H. Lochmüller -- Congenital muscular dystrophies / S.E. Sparks and D.M. Escolar -- The collagen VI-related myopathies : Ullrich congenital muscular dystrophy and Bethlem myopathy / C.G. Bönnemann -- Limb-girdle muscular dystrophy 2A / E. Gallardo, A.Saenz and I.Iilla -- Dysferlinopathies / A.A. Amato and R.H. Brown Jr -- Other limb-girdle muascular dystrophies / A.A. Amato -- Limb-girdle muscular dystrophy 2H and the role of TRIM32 / P.B. Shieh, E. Kudryashova and M.J. Spencer -- Caveolinopathies : translational implications of caveolin-3 in skeletal and cardiac muscle disorders / E. Gazzerro, A. Bonetto, and C. Minetti -- Myofibrillar myopathies / D. Selcen and A.G. Engel -- Emery-Dreifuss muscular dystrophy / M. Puckelwartz and E.M. McNally -- Facioscapulohumeral dystrophy and scapuloperoneal syndromes / R.W. Orrell -- Oculopharyngeal muscular dystrophy / B. Brais -- Myotonic dystrophy types 1 and 2 / T. Ashizawa and P.S. Sarkar -- Distal muscular dystrophies / B. Udd.
  • Introduction to muscular dystrophy / Raymond A. Huml -- Muscular dystrophy : historical background and types / Raymond A. Huml -- FSHD : the most common type of muscular dystrophy? / Raymond A. Huml and Daniel P. Perez -- Duchenne and Becker muscular dystrophies : underlying genetic and molecular mechanisms / Jean K. Mah -- An overview of the other muscular dystrophies : underlying genetic and molecular mechanisms / Jean K. Mah -- Transition from childhood to adult in patients with muscular dystrophy / Elba Yesi Gerena Maldonado and Kathryn R. Wagner -- Overview of current treatments for muscular dystrophy / Zheng (Jane) Fan -- Physical therapy and orthotic devices / Laura E. Case -- Orthopedic management of the child with muscular dystrophy / Robert K. Lark and Elizabeth W. Hubbard -- Global regulatory landscape / Raymond A. Huml -- Key challenges to the approval of products to treat patients with muscular dystrophy / Raymond A. Huml -- Pharmaceutical products and non-pharmaceutical interventions as potential treatments for patients with muscular dystrophy / Raymond A. Huml -- US patient advocacy groups / Meredith L. Huml -- Global and national patient registries / Raymond A. Huml -- Summary / Raymond A. Huml.
  • Written by internationally renowned experts, this updated volume is a collection of chapters dealing with imaging diagnosis and interventional therapies in musculoskeletal diseases. The different topics are disease-oriented and encompass all the relevant imaging modalities including X-ray technology, nuclear medicine, ultrasound and magnetic resonance, as well as image-guided interventional techniques. This publication, includingexcellent radiologicimages andcolor illustrations,will appeal not onlytoradiologists, rheumatologists, orthopaedics surgeons, but also to clinicians in other specialties wishing to update their knowledge in this field.
  • General Principles of Initial Care -- Radiographic Imaging -- Infections Involving the Musculoskeletal System -- Analgesia, Conscious Sedation, Regional Blocks, and Anesthesia -- Analgesia, Conscious Sedation, Regional Blocks, and Anesthesia -- Perioperative Assessment -- Pregnancy -- Spine -- Shoulder -- Elbow and Distal Humerus -- Wrist and Forearm -- Hand and Digits -- Hip and Thigh -- Distal Femur, Knee, and Patella -- Ankle -- Foot -- Pelvis -- Introduction to Pediatric Trauma -- Pediatric Pathologic Fractures --Pediatric Shoulder and Humeral Shaft -- Pediatric Elbow -- Pediatric Forearm and Distal Radius and Ulna Fractures -- Pediatric Hand Injuries -- Pediatric Cervical Spine Fractures -- Pediatric Thoracolumbar Spine Fractures -- Pediatric Thoracolumbar Spine Fractures -- Pediatric Fractures and Dislocations of the Hip -- Pediatric Femur -- Fractures of the Pediatric Knee -- Pediatric Tibia and Fibular Shaft and Ankle Fractures -- Pediatric Foot -- Appendix Administrative and Regulatory Issues Relating to Emergency Department Management of Musculoskeletal Emergencies.
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    Basic concepts of physical examination -- Overview of the spine and pelvis -- The cervical spine and thoracic spine -- The temporomandibular joint -- The lumbosacral spine -- Overview of the upper extremity -- The shoulder -- The elbow -- The wrist and hand -- The hip -- The knee -- The ankle and foot -- Gait.
  • ch. 1. Incidence and prevalence of stress fractures in military and athletic populations / Richard A. Shaffer -- ch. 2. Risk factors for developing stress fractures / Kim Bennell and Susan Grimston -- ch. 3. Factors associated with the development of stress fractures in women / Kim Bennell and Susan Grimston -- ch. 4. The role of age in the development of stress and fatigue fractures / Antero Hulkko and Sakari Orava -- ch. 5. The prediction of stress fractures / Thomas J. Beck -- ch. 6. Bone fatigue and stress fractures / Scott A. Yerby and Dennis R. Carter -- ch. 7. The Genetic basis for stress fractures / Eitan Friedman, Iris Vered, and Jushua Shemer -- ch. 8. The role of strain and strain rates in stress fractures / Charles Milgrom -- ch. 9. The Role of muscular force and fatigue in stress fractures / Seth W. Donahue -- ch. 10. The histological appearance of stress fractures / Satoshi Mori, Jiliang Li, and Yoji Kawaguchi -- ch. 11. Bone fatigue and remodeling in the development of stress fractures / Mitchell B. Schaffler -- ch. 12. The role of bone remodeling in preventing or promoting stress fractures / R. Bruce Martin -- ch. 13. Bucked shins in horses / David Nunamaker -- ch. 14. Rabbits as an animal model for stress fractures / David B. Burr -- ch. 15. Prevention of stress fractures by modifying shoe wear / Aharon S. Finestone -- ch. 16. Exercise programs that prevent or delay the onset of stress fracture / Charles Milgrom and Richard Shaffer -- ch. 17. Pharmaceutical treatments that may prevent or delay the onset of stress fractures / David B. Burr -- ch. 18. Physical diagnosis of stress fractures / Ingrid Ekenman -- ch. 19. The role of various imaging modalities in diagnosing stress fractures / Roland Chisin -- ch. 20. Early diagnosis and clinical treatment of stress fractures / Charles Milgrom and Eitan Friedman -- ch. 21. Problematic stress fractures / Kenneth A. Egol and Victor H. Frankel.
  • Providing clinicians with a comprehensive, evidence-based summary of musculoskeletal health in pregnancy and postpartum, this is the first book of its kind to describe the physiologic changes, prevalence, etiology, diagnostic strategies, and effective treatments for the most common musculoskeletal clinical conditions encountered during this phase of life. Lumbopelvic pain, upper and lower extremity diagnoses, labor and delivery considerations, including the impact on the pelvic floor, and medical therapeutics will be discussed. Additionally, the importance and influence of exercise in pregnancy, the long-term implications of musculoskeletal health in pregnancy and current and future directions for research will be addressed. The childbearing period is a time of remarkable reproductive and musculoskeletal change, predisposing women to potential injury, pain, and resultant disability. Musculoskeletal Health in Pregnancy and Postpartum offers musculoskeletal medicine specialists, obstetricians and any clinicians involved in the care of pregnant or postpartum women the tools necessary to prepare for, treat and prevent these concurrent injuries during an already challenging time.
  • Musculoskeletal Health in Women aims to provide fitness advice tailored to women. As women are more prone to specific injuries than men are, due to differences in hip and knee anatomy as well as hormonal differences, this book will provides a fully-illustrated and comprehensive overview of all aspects including energy availability (which is affected by eating disorders), osteoporosis, and menstrual function. Its multidisciplinary approach ensures that expertise is provided from disciplines such as psychiatry, physiatry, endocrinology, nutrition, rheumatology, orthopedics, physical therapy and radiology. Written by authors who have extensive experience working with women athletes, Musculoskeletal Health in Women addresses a full spectrum of issues related to the musculoskeletal health of women. It is of primary interest to women athletes and women embarking on a fitness regimen. Health professionals working in this area would also invariably benefit from the advice and guidance provided within these pages.
  • Musculoskeletal imaging 2008
    Thieme Book
    1. Tumors -- Osteoma -- Osteoid osteoma -- Enchondroma -- Osteochondoroma (cartilaginous exostosis) --Nonossifying fibroma -- Fibrous dysplasia (Jaffe-Lichtenstein Disease) -- Juvenile bone cyst -- Aneurysmal bone cyst -- Giant cell tumor (Osteoclastoma) -- Synovial chondromatosis (Reichel Syndrome) -- Bone hemangioma -- Paget Diesase (Ostetis Deformans) --Metastases -- Osteosarcoma -- Ewind sarcoma -- Multiple myeloma (plasmacytoma) -- Lymphoma of bone -- Neoplastic vertebral compression fracture -- Soft-tissue hemangioma -- Soft-tissue sarcoma -- Lipoma -- Pigmented villonodular synovitis -- Myositis ossificans -- 2. Inflammatory diseases -- Osteomyelitis -- Brodie abscess -- Rheumatoid arthritis -- Psoriatic arthritis/psoriatic arthropathy -- Septic arthritis -- Gout (gouty arthritis) -- Ankylosing spondylitis -- Spondylitis and spondylodiskitis -- Complex regional pain syndrome -- 3. Degenerative disease -- Osteoarthritis -- Osteochondrosis -- Intervertebral disk herniation -- Spinal canal stenosis -- Spondylolysis/spondylolisthesis -- Implant loosening -- Diffuse idiopathic skeletal hyperostosis -- Neuropathic osteoarthropathy (charcot joint) -- 4. Metabolic disorders -- Osteoporosis -- Rickets -- Osteomalacia -- Hyperparathyroidism -- 5. Developmental disorders -- Madelund deformity -- Hip dysplasia -- Tibia vara (Blount Disease) -- Slipped capital femoral epiphysis -- Club foot (talipes equinovarus) -- Scoliosis -- Osteogenesis imperfecta -- Osteopetrosis (Marble Bone Disease) -- Scheuermann Disease -- 6. Osteonecrosis -- Perthes Disease -- Osteonecrosis of the knee -- Lunatomalacia (Kienbock Disease) -- Femoral head necrosis -- Osteochondritis dissecans -- Bone infarct -- 7. Intra-articular lesions -- Meniscal lesions -- Cruciate ligament tears -- Cartilage lesions -- Labral lesions -- Rotator cuff lesions -- 8. Ligament and tendon injuries -- Lateral ankle ligament rupture -- Achilles tendon rupture -- Avulsion fracture -- Shoulder impingement -- 9. Fractures and dislocations -- Clavicle fracture -- Acromioclavicular separation -- Proiximal humerus fractures -- Shoulder dislocation -- Radial head fracture -- Pediatric condylar fractures -- Distal radius fracture -- scaphoid fracture -- Triquetrum fracture -- Skier's thumb (gamekeeper's thumb) -- Dens fracture -- Femoral neck fracture -- pertrochanteric femoral fracture -- Patella fracture -- Tibial plateau fracture -- Ankle joint fractures -- Calcaneus fracture -- Fractures of the base of the fifth metatarsal -- Occult fracture -- Stress fracture - Pseudarthrosis.
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  • This volume uses 200 case studies to challenge your knowledge of a full range of topics in musculoskeletal imaging. Whether you are preparing for the radiology board exams, recertifying, or looking to hone your diagnostic abilities, this book will help you read and interpret all imaging modalities used for the musculoskeletal system.
  • What Is Musculoskeletal Medicine? -- The Scientific Bases of Musculoskeletal Medicine -- The Patient's View of Musculoskeletal Medicine -- The Doctor's View of Musculoskeletal Medicine -- The Economics of Musculoskeletal Medicine -- Teaching Musculoskeletal Medicine -- Headache and Migraine -- Neck Pain -- Shoulder and Arm Pain -- Chest Pain -- Lower Trunk Pain -- Pelvic Pain -- Leg Pain -- Will Musculoskeletal Medicine Work? -- The Future of Musculoskeletal Medicine.
  • Basic principles of musculoskeletal MRI -- Marrow -- Tendons and muscles -- Peripheral nerves -- Musculoskeletal infections -- Arthritis and cartilage -- Tumors -- Osseous trauma -- Temporomandibular joint -- Shoulder -- Elbow -- Wrist and hand -- Spine -- Hips and pelvis -- Knee -- Foot and ankle.
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  • RadCases contains cases selected to simulate everything that you'll see on your rounds, rotations, and exams. RadCases also helps you identify the correct differential diagnosis for each case - including the most critical. RadCases covers: cardiac imaging, interventional radiology, musculoskeletal imaging, neuro imaging, chest imaging, pediatric imaging, gastrointestinal imaging, breast imaging, nuclear medicine, ultrasound imaging, head and neck imaging, and genitourinary imaging. Each RadCases title features 100 carefully selected, must-know cases documented with clear, high-quality radiographs. The organization provides maximum ease of use for self-assessment. Each case begins with the clinical presentation on the right-hand page; simply turn the page for imaging findings, differential diagnoses, the definitive diagnosis, essential facts, and more. Each RadCases title includes a scratch-off code that allows 12 months of access to a searchable online database of all 100 cases from the book plus an additional 150 cases in that book's specialty - 250 cases in total! Learn your cases, diagnose with confidence and pass your exams.
  • 1. Fundamentals of musculoskeletal ultrasound -- 2. Pitfalls in musculoskeletal ultrasound -- 3. Rheumatod arthritis -- 4. Ankylosing spondylitis -- 5. Psoriatic arthritis -- 6. Osteoarthritis -- 7. Crystal-induced arthritis -- 8. Skin, nail and hair in rheumatology -- 9. Pediatric musculoskeletal disorders -- 10. Carpal tunnel syndrome -- 11. Soft tissue rheumatism -- 12. Inflammatory allied conditions -- 13. Sports medicine -- 14. Ultrasound-guided interventional maneuvers -- Index.
  • With an emphasis on the accuracy and dynamic nature of no-radiation ultrasound, leading clinicians from around the world provide practical guidance on how to combine different multiplanar imaging modalities in the analysis and diagnosis of common musculoskeletal disorders. Organized by body region, each of the 13 chapters follows a consistent, easy-to-reference format. The authors guide the reader through clinical indications, technical guidelines, and normal anatomy followed by information on degenerative diseases, inflammatory conditions, traumatic injuries, tumors, and various other musculoskeletal problems. Clear, high-resolution ultrasound images appear side by side with MRI, and in some cases CT, images to teach and train readers how to perform musculoskeletal ultrasound in clinical practice while simultaneously sharpening their diagnostic skills.
  • Introduction : music that works / Roland Haas -- Sonification : listen to brain activity / Gerald Baier, Thomas Hermann -- Chronobiology, as a foundation for and an approach to a new understanding of the influence of music / Hans-Ullrich Balzer -- Music as medicine : incorporating scalable music-based interventions into standard medical practice / Vera Brandes -- A perspective on evidence-based practice / Cheryl Dileo, Joke Bradt -- The audio-vocal system in song and speech development / Wilfried Gruhn -- The significance of exposure to music for the formation and stabilisation of complex neuronal relationship matrices in the human brain : implications for the salutogenetic effects of intervention by means of music theory / Gerald Hüther -- Music and the self / Petr Janata -- Neural substrates of processing syntax and semantics in music / Stefan Koelsch -- A city upon a hill : making scientific progress in brain-based music research in typical development, autism, and other disorders / Nicolas Lange, Janet E. Lainhart -- The rhythm of the heart, the tempus of music : Mozart, Ligeti, and the rat / Björn Lemmer -- Music and child neurology : a developmental perspective / Luisa Lopez -- Prenatal "experience" and the phylogenesis and ontogenesis of music / Richard Parncutt -- Music and the evolution of human brain function / Juan G. Roederer -- Clinical applications of music therapy in neurologic rehabilitation / Concetta M. Tomaino -- Human biochronology : on the source and functions of "musicality" / Colwyn Trevarthen -- A study of synchronisation behaviour in a group of test persons during Basky and Dhikr exercises via psycho-physiological monitoring / Gerhard Tucek, Elisabeth Ferstl, Florentina Maria Fritz -- Resonance and silence : the significance in medicine / Rolf Verres -- Emotion modulation by means of music and coping behaviour / Richard von Georgi, Miriam Göbel, Stefan Gebhardt -- Identifying the effectiveness of a music-based auditory stimulation method, on children with sensory integration and auditory processing concerns : a pilot study / John Esteves ... [et al.] -- Music as a medicine : incorporating music into standard hospital care / Vera Brandes.
  • Music, Neurology, and Neuroscience: Historical Connections and Perspectives provides a broad and comprehensive discussion of history and new discoveries regarding music and the brain, presenting a multidisciplinary overview on music processing, its effects on brain plasticity, and the healing power of music in neurological and psychiatric disorders. In this context, the disorders that plagued famous musicians and how they affected both performance and composition are critically discussed, as is music as medicine and its potential health hazard. Additional topics, including the way music fits into early conceptions of localization of function in the brain, its cultural roots in evolution, and its important roles in societies and educational systems are also explored.Examines music and the brain both historically and in the light of the latest research findings The largest and most comprehensive volume on "music and neurology" ever writtenWritten by a unique group of real world experts representing a variety of fields, ranging from history of science and medicine, to neurology and musicology Includes a discussion of the way music has cultural roots in evolution and its important role in societies
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    Haunted by music. A bolt from the blue : sudden musicophilia ; A strangely familiar feeling : musical seizures ; Fear of music : musicogenic epilepsy ; Music on the brain : imagery and imagination ; Brainworms, sticky music and catchy tunes ; Musical hallucinations -- A range of musicality. Sense and sensibility : a range of musicality ; Things fall apart : amusia and dysharmonia ; Papa blows his nose in G : absolute pitch ; Pitch imperfect : cochlear amusia ; In living stereo : why we have two ears ; Two thousand operas : musical savants ; An auditory world : music and blindness ; The key of clear green : synesthesia and music -- Memory, movement, and music. In the moment : music and amnesia ; Speech and song : aphasia and music therapy ; Accidental davening : dyskinesia and cantillation ; Come together : music and Tourette's Syndrome ; Keeping time : rhythm and movement ; Kinetic melody: Parkinson's disease and music therapy -- Phantom fingers: the case of the one-armed pianist ; Athletes of the small muscles : musician's dystonia -- Emotion, identity, and music. Awake and asleep : musical dreams ; Seduction and indifference ; Lamentations : music and depression ; The case of Harry S. : music and emotion ; Irrepressible : music and the temporal lobes ; A hypermusical species : Williams Syndrome ; Music and identity : dementia and music therapy.
  • Everyday Islam: How Muslims Practice Their Religion -- Some Basic Islamic Concepts and How Islam Fits in to the Judeo-Christian Tradition -- The Story of an Arab, an Angel, and the God of Abraham: Muhammad and the Birth of Islam -- The Qur'an: What It Is and Why Quoting It Can Be Problematic -- Who's Who in Islam: From Ayatollahs to Whirling Dervishes -- Religious Hierarchy: Who Makes the Rules in Islam? -- Women in Islam: Marriage, Divorce, Polygamy, and that Veil Thing -- Jihad and Fundamentalism: Not the Same -- Theft and Adultery in Islam: Reflections on Disney's Aladdin -- An American Muslim Reaction to September 11th -- Why the Misconceptions Persist: Separating the Reality from the Murky Mythology.
  • This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
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    The author recounts his lifelong battle with anxiety, showing the many manifestations of the disorder as well as the countless treatments that have been developed to counteract it, and provides a history of the efforts to understand this common form of mental illness.
  • My NCBI help documentation 2005
    NCBI Bookshelf
    "This book contains information on how to use My NCBI, a tool developed by the National Center for Biotechnology Information (NCBI) that replaces a previous feature called Cubby. This documentation is part of a growing collection of searchable help documents being produced for several resources available at NCBI."
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    On December 10, 1996, Taylor, a brain scientist, experienced a massive stroke. She observed her own mind deteriorate. Now she shares her unique perspective on the brain and its capacity for recovery.
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    The anatomy and molecular architecture of the neuromuscular junction / Andrew G. Engel -- Electrodiagnosis of myasthenic disorders / Michel Harper -- The immunopathogenesis of myasthenia gravis / Reinhard Hohlfeld, Hartmut Wekerle, and Alexander Marx -- Natural history of myasthenia gravis / Vladimir Luchanok and Henry J. Kaminski -- The diagnosis of myasthenia gravis and other disorders of neuromuscular transmission / James F. Howard -- Therapy of myasthenia gravis / Daniel B. Drachman -- The Lambert-Eaton myasthenic syndrome / Vern C. Juel and Donald B. Sanders -- Congenital myasthenic syndromes / Andrew G. Engel ... [et al.] -- End-plate acetylcholine receptor : a target for myasthenic disorders : structural and mechanistic essentials / Steven M. Sine and Andrew G. Engel -- Peripheral nerve hyperexcitability syndromes / Srikanth Muppidi and Steven Vernino -- Effects of antiganglioside antibodies at the neuromuscular junction / Jaap J. Plomp and Hugh J. Willison.
  • Neuromuscular junction physiology and pathophysiology / Eroboghene E. Ubogu and Robert L. Ruff -- Acetylcholine receptor structure / Jon M. Lindstrom -- Immunopathogenesis of myasthenia gravis / Bianca M. Conti-Fine ... [et al.] -- Epidemiology and genetics of myasthenia gravis / Jeremiah W. Lanford, Lawrence H. Phillips -- Clinical presentation and epidemiology of myasthenia gravis / Jan B.M. Kuks -- Ocular myasthenia / Robert B. Daroff and Michael Benatar -- Thymoma-associated paraneoplastic myasthenia gravis / Philipp Ströbel, Wen-Yu Chuang, and Alexander Marx -- Electrodiagnosis of neuromuscular junction disorders / Bashar Katirji -- Autoantibody testing in the diagnosis and management of autoimmune disorders of neuromuscular transmission and related diseases / Mark A. Agius, David P. Richman, and Angela Vincent -- Treatment of myasthenia gravis / Henry J. Kaminski -- Neurocritical care of myasthenic crisis / J. Americo Fernandes Filho and Jose I. Suarez -- Thymectomy for non-thymomatous MG / Alfred Jaretzki III and Joshua R. Sonett -- Lambert-Eaton syndrome / Charles M. Harper, Vanda A. Lennon -- Acquired neuromyotonia -- Angela Vincent and Ian Hart -- Congenital myasthenic syndromes / David Beeson -- Toxic neuromuscular transmission disorders / James F. Howard, Jr. -- The impact of myasthenia gravis on mood, cognitive function, and quality of life / Robert H. Paul, Larry L. Mullins, and James M. Gilchrist -- Myasthenia gravis : classification and outcome measurements / Gil I. Wolfe and Richard J. Barohn.
  • Myc gene methods and protocols 2013
    Springer Protocols
  • Making Myc / J. Liu and D. Levens -- Transcriptional activation by the Myc oncoprotein / M. D. Cole and M. A. Nikiforov -- Mechanisms of transcriptional repression by Myc / D. Kleine-Kohlbrecher, S. Adhikary and M. Eilers -- The mad side of the Max network : antogonizing the function of Myc and more / S. Rottmann and B. Luscher -- Structural aspects of interactions with the Myc/Max/Mad network / S. K. Nair and S. K. Burley -- Myc target transcriptomes / L. A. Lee and C. V. Dang -- c-Myc, genome instability, and tumorigenesis : the devil is in the details / M. Wade and G. M. Wahl -- Lessons learned from Myc/Max/Mad knockout mice / M. Pirity, J. K. Blanck and N. Schreiber-Agus -- Myc/Max/Mad in invertebrates : the evolution of the Max network / P. Gallant -- The mix network : evidence for a parallel Max-like transcriptional network that regulates energy metabolism / A. N. Billin and D. E. Ayer.
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  • Mycota v. 1, 4, [5], 6, 8-10, 13-15, 2006-12.
  • Mycotoxin protocols
    Springer Protocols
  • v. 1. Biology -- v. 2. Disorders.
  • Development of Oligodendrocytes in the Vertebrate CNS / Robert H. Miller -- Demyelination and Remyelination in Multiple Sclerosis / Lars Bø, Margaret Esiri, Nikos Evangelou and Tanja Kuhlmann -- Microglial Function in MS Pathology / Trevor J. Kilpatrick and Vilija G. Jokubaitis -- Endogenous Remyelination in the CNS / Robin J. M. Franklin, Chao Zhao, Catherine Lubetzki and Charles ffrench-Constant -- Exogenous Cell Myelin Repair and Neuroprotection in Multiple Sclerosis / Ian D. Duncan and Yoichi Kondo -- A Peripheral Alternative to Central Nervous System Myelin Repair / V. Zujovic and A. Baron Van Evercooren -- Immune Modulation and Repair Following Neural Stem Cell Transplantation / Tamir Ben-Hur, Stefano Pluchino and Gianvito Martino -- Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis / Joel A. Black, Kenneth J. Smith and Stephen G. Waxman -- Effects of Current Medical Therapies on Reparative and Neuroprotective Functions in Multiple Sclerosis / Jack P. Antel and Veronique E. Miron -- Imaging of Demyelination and Remyelination in Multiple Sclerosis / Douglas L. Arnold, Catherine M. Dalton, Klaus Schmierer, G. Bruce Pike and David H. Miller -- Designing Clinical Trials to Test Neuroprotective Therapies in Multiple Sclerosis / P. Connick, M. Kolappan, A. Compston and S. Chandran.
  • In 1961, neurobiologists found that the conduction velocity of the nerve impulse in the giant nerve fiber of the Penaeus shrimp abdominal nerve cord was over 200 m/s, the highest speed of information transmission ever observed in the animal kingdom. The peculiar myelin sheath with its unique nodal structure and the electrical properties of the nerve fibers of the shrimp have continued to be investigated for a quarter of century and are now fully described in this book. The investigation dispels the commonly held belief that the fastest recorded impulse conduction is about 120 m/s in the thickest vertebrate myelinated nerve fibers. In the shrimp, researchers found a completely novel type of functional node in the giant fiber which they designated as the fenestration node. In portions of the myelinated fiber, the fenestration node furnished the sites of excitation. Also discovered was a new strategy for increasing impulse conduction in the shrimp. The book includes a section on the formation of the fenestration node and the discovery of a strategy that allows the shrimp to escape its predators by an action of the fastest velocity. The data presented in this volume on the myelin sheath of invertebrates present a new direction for this field and a rich source of information for neurobiologists worldwide.
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    Clinical and prognostic characterization of myelodysplastic syndromes / Peter L. Greenberg -- Morphologic classifications of myelodysplastic syndromes : French-American-British (FAB) and World Health Organization (WHO) / Richard D. Brunning -- Pathogenetic mechanisms underlying myelodysplastic syndromes / Peter L. Greenberg -- Cytogenetic abnormalities in myelodysplastic syndromes / Harold J. Olney and Michelle M. Le Beau -- Molecular mechanisms and gene expression patterns in myelodysplastic syndromes / Wolf-Karsten Hofmann and H. Phillip Koeffer -- Immunologic mechanisms and treatment of myelodysplastic syndromes / A. John Barrett, Elaine Sloand and Neal S. Young -- Biologically targeted therapies for myelodysplastic syndromes / Andrew J. Buresh and Alan F. List -- Supportive care in myelodysplastic syndromes : hemopoietic cytokine and iron chelation therapy / Jason Gotlib and Peter L. Greenberg -- Hematopoietic cell transplantation for myelodysplastic syndromes / H. Joachim Deeg and Bart Scott -- Health-related quality of life in myelodysplastic syndromes : conceptualization, measurement, and implications for research and practice / Mary Laudon Thomas.
  • Part I. Epidemiology and clinical presentation -- Clinical presentation and differential diagnosis -- Epidemiology and etiology -- Part II. Pathology, pathophysiology and staging -- Cytogenetic diagnosis of myelodysplastic syndromes -- MDS stem cell biology -- The biology of myelodysplastic syndrome associated with Isolated del(5q) -- A personalized molecular pathogenesis of MDS -- Myelodysplastic/myeloproliferative neoplasms -- Classification and staging of myelodysplastic syndromes -- Immunophenotyping in myelodysplastic syndromes -- Prognostic models for patients with myelodysplastic syndromes -- Part III. Treatment -- Management of low-risk MIDS -- Management of high-risk myelodysplastic syndrome -- Hematopoietic cell transplantation (HCT) -- Part IV. MIDS in children -- Myelodysplastic syndrome in children.
  • Diagnosis and monitoring of AML1-MTG8 (ETO)-positive acute myeloid leukemia by qualitative and real-time quantitative RT-PCR / Khalid Tobal and John A. Liu Yin -- Diagnosis and monitoring of CBFB-MYH11-positive acute myeloid leukemia by qualitative and quantitative RT-PCR / Bert A. van der Reijden and Joop H. Jansen -- Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia / Jan Cools, Elizabeth H. Stover, and D. Gary Gilliland -- FLT3 mutations in acute myeloid leukemia / Hitoshi Kiyoi and Tomoki Naoe -- WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes / Daniela Cilloni, Enrico Gottardi, and Giuseppe Saglio -- Classification of AML by DNA-oligonucleotide microarrays / Alexander Kohlmann ... [et al.] -- Classification of AML using a monoclonal antibody microarray / Richard I. Christopherson ... [et al.] -- Isolation of RNA and DNA from leukocytes and cDNA synthesis / Joop H. Jansen and Bert A. van der Reijden -- Cytogenetics and FISH techniques in myeloid malignancies / Lynda J. Campbell -- Overview of real-time RT-PCR strategies for quantification of gene rearrangements in the myeloid malignancies / Christophe Picard, Monique Silvy, and Jean Gabert -- Diagnosis and monitoring of chronic myeloid leukemia by qualtitative and quantitative RT-PCR / Susan Branford and Timothy Hughes -- Detection of BCR-ABL mutations and resistance to imatinib mesylate / Susan Branford and Timothy Hughes -- Deletion of the derivative chromosome 9 in chronic myeloid leukemia / Lynda J. Campbell -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR / Vincenzo Rossi, Laura Levati, and Andrea Biondi -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by quantitative RT-PCR / Elisa Mokany ... [et al.] -- Methods for the detection of the JAK2 V617F mutation in human myeloproliferative disorders / Peter J. Campbell ... [et al.] -- Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia / Maurizio Martini, Luciana Teofili, and Luigi M. Larocca -- Chimerism analysis following nonmyeloablative stem cell transplantation / Thomas Lion and Franz Watzinger.
  • Clinical Presentation of Myeloma Bone Disease / Rebecca Silbermann and G. David Roodman -- Imaging of Multiple Myeloma, Solitary Plasmacytoma, MGUS, and Other Plasma Cell Dyscrasias / Ronald C. Walker, Laurie Jones-Jackson, Twyla Bartel, Tracy Brown and Bart Barlogie -- Biochemical Markers of Bone Remodeling in Multiple Myeloma / Evangelos Terpos -- Radiation Therapy in Multiple Myeloma / Joel S. Greenberger -- Surgical Management of Bone Disease / Mohamad A. Hussein -- Bisphosphonates in the Treatment of Myeloma Bone Disease / James R. Berenson -- Osteonecrosis of the Jaw / Ashraf Badros -- Murine Models of Myeloma Bone Disease: The Importance of Choice / Peter I. Croucher, Karin Vanderkerken, Joshua Epstein and Babatunde Oyajobi -- RANK Ligand Is a Therapeutic Target in Multiple Myeloma / William C. Dougall, Michelle Chaisson-Blake, Howard Yeh and Susie Jun -- Osteoclast Activation in Multiple Myeloma / Sonia Vallet and Noopur Raje -- Potential Role of IMiDs and Other Agents as Therapy for Myeloma Bone Disease / Suzanne Lentzsch -- Proteasome Inhibitors and the Wnt Signaling Pathway in Myeloma Bone Disease / Claire M. Edwards and Gregory R. Mundy -- Mechanisms Involved in Osteoblast Suppression in Multiple Myeloma / Nicola Giuliani.
  • Myeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of these diseases have arisen following the discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative MPNs. This book comprises evidence-based reviews and expert consensus results. It offers comprehensive coverage of relevant laboratory and clinical advances and places great emphasis on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.
  • Diagnosis and classification of the BCR-ABL1-negative myeloproliferative neoplasms -- Genetics of the myeloproliferative neoplasms -- Cytogenetic findings in classical MPNs -- Prognostic factors in classic myeloproliferative neoplasms -- Therapy of polycythemia vera and essential thrombocythemia -- Conventional and investigational therapy for primary myelofibrosis -- Hematopoietic cell transplantation for myelofibrosis -- JAK2 inhibitors for therapy of myeloproliferative neoplasms -- Blastic transformation of classic myeloproliferative neoplasms -- Eosinophilic disorders: differential diagnosis and management -- Pathogenesis, diagnosis, classification, and management of systemic mastocytosis.
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    Autosomal dominant cortical myoclonus and epilepsy (ADCME) with linkage to chromosome 2p11.1-Q12.2 / Renzo Guerrini ... [et al.] -- Familial adult-onset myoclonic epilepsy (FAME) / Eiichiro Uyama, Ying-Hui Fu, and Louis J. Ptácek -- Treatment of myoclonic epilepsies in infancy and early childhood / Raman Sankar ... [et al.] -- Ketogenic diet in patients with Dravet syndrome and myoclonic epilepsies in infancy and early childhood / Natalio Fejerman, Roberto Caraballo, and Ricardo Cersosimo -- Treatment of myoclonic epilepsies of childhood, adolescence, and adulthood / Marco T. Medina ... [et al.]. History and classification of "myoclonic" epilepsies: from seizures to syndromes to diseases / Pierre Genton ... [et al.] -- Ontogeny of the reticular formation: its possible relation to the myoclonic epilepsies / Harvey B. Sarnat -- Pathophysiology of myoclonic epilepsies / Renzo Guerrini ... [et al.] -- Progressive myoclonus epilepsies: EPM1, EPM2A, EPM2B / Berge Minassian, E. M. Chan, and Silvana Franceschetti -- Myoclonic status in non-progressive encephalopathies / Bernardo Dalla Bernardina, Elena Fontana, and Francesca Darra -- Severe myoclonic epilepsy in infancy: Dravet's syndrome / Charlotte Dravet ... [et al.] -- Severe myoclonic epilepsy in infancy: clinical analysis and relation to SCN1A mutations in a Japanese cohort / Hirokazu Oguni ... [et al.] -- Myoclonic seizures in the context of generalized epilepsy with febrile seizures plus (GEFS+) / Michel Baulac ... [et al.] -- Benign myoclonic epilepsy in infancy / Charlotte Dravet and Michelle Bureau -- Autosomal recessive benign myoclonic epilepsy of infancy / Federico Zara and Fabrizio A. De Falco -- Myoclonic astatic epilepsy of early childhood-definition, course, nosography, genetics / B.A. Neubauer, A. Hahn, and H. Doose -- Idiopathic myoclonic-astatic epilepsy of early childhood-nosology based on electrophysiological and long-term follow-up study of patients / Hirokazu Oguni ... [et al.] -- Myoclonic absences: the seizure and the syndrome / Michelle Bureau and Carlo Alberto Tassinari -- Eyelid myoclonia and absence / Athanasios Covanis -- Childhood absence epilepsy evolving to juvenile myoclonic epilepsy: electroclinical and genetic features / Marco T. Medina ... [et al.] -- Photosensitivity: genetics and clinical significance / B.A. Neubauer ... [et al.] -- Familial juvenile myoclonic epilepsy / Maria Elisa Alonso ... [et al.] -- Genetics of JME: faulty components and faulty wiring? / Martina Durner, Deb Pal, and David Greenberg -- Autosomal dominant juvenile myoclonic epilepsy and GABRA1 / Patrick Cossette ... [et al.] -- CLCN2 and idiopathic generalized epilepsy / Armin Heils --
  • Edited by Dominik Irnich, MD, this clearly written and fully illustrated multi-contributor volume offers practical, comprehensive coverage of the subject area ranging from the latest scientific research findings to practical usage of current manual therapy techniques. Including the latest information from centres of excellence throughout the world, this new book is suitable for osteopathic physicians, osteopaths, chiropractors, manual therapists, physiotherapists, acupuncturists and massage therapists as well as general physicians working in primary care, physical medicine, rehabilitation, pain management and internal medicine. Offers practical and clinically relevant information to all practitioners and therapists working in the field Edited by an international expert in pain management and trigger point therapy Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Carefully prepared by a worldwide team of clinically active and research oriented contributors to provide helpful and clinically relevant information Presents the latest research findings for many aspects of trigger point therapy Provides a holistic view of patient care including the importance of patient communication and psychological aspects of pain control Provides a handy reference for rapid and effective diagnosis and treatment of trigger points Highlights the 65 most important muscles in a comprehensive practical style which includes anatomy, symptoms, pain patterns, physical examination and strategies for effective treatment Offers an ideal resource for training courses in trigger point injection, osteopathy, manual therapy and acupuncture Suitable for osteopathic physicians, osteopaths, chiropractors, manual therapists, acupuncturists and massage therapists as well as general physicians working in primary care, physical medicine, rehabilitation, pain management and internal medicine.
  • Myopathies 2007
  • The structural and functional diversity of the myosin family of actin-based molecular motors / M.S. Mooseker and B.J. Foth -- Myosin structure / K.C. Holmes -- The myosin family: Biochemical and kinetic properties / M. El-Mezgueldi and C.R. Bagshaw -- Myosin I / L.M. Coluccio -- Myosin II : Sarcomeric myosins, the motors of contraction in cardiac and skeletal muscles / C. Reggiani and R. Bottinelli -- Smooth-muscle myosin II / C.R. Cremo and D.J. Hartshorne -- Non-muscle myosin II / M. Conti, S. Kawamoto and R.S. Adelstein -- Class III myosins / A. Dosé, J. Lin-Jones and B. Burnside -- Myosin V / J.R. Sellers and L.S. Weisman -- Myosin VI : A multifunctional motor protein / F. Buss and J. Kendrick-Jones -- Myosin VII / A. El-Amraoui, A. Bahloul and C. Petit -- Plant myosins VIII, XI, and XIII / K. Yamamoto -- Class IX myosins / M. Bähler -- Myosin X / M.M. Divito and R.E. Cheney -- Myosin class XIV and other myosins in protists / K. Frénal, B.J. Foth and D. Soldati -- Myosin XVa / E.T. Boger ... [et al.].
  • This book offers dozens of short, focused pieces of code and hundreds of worked-out examples for programmers of all levels who don't have the time or expertise to solve MySQL problems from scratch. Each recipe explains how and why the code works, so you'll learn as you. This new edition covers MySQL 5.0 and its powerful new features, along with the older but still widespread MySQL 4.1.
  • The first complete and authoritative book on yawning.

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A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines. Over 10,000 notes outline the status of specific infections within each country.
Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.