Books

Contents:
General principles / R. Darrell Nelson and Jonah Gunalda
Anesthesia and analgesia / Tarlan Hedayati
Rheumatology / Todd Taylor, Usama Khalid, and Jehangir Meer
Complications / Erik Nordquist
Special imaging techniques / Joy L. English
Pediatrics / Ghazala Q. Sharieff
Approach to neck and back pain / Zheng Ben Ma and Emily Senecal Miller
Specific disorders of the spine / Andrew D. Perron and Carl A. Germann
Cervical spine trauma / Michael E. Nelson
Thoracolumbar spine trauma / Sean Dyer
Hand / David E. Manthey and Kim L. Askew
Wrist / Andrea L. Blome and Megan E. Healy
Forearm / Eric Toth and James Webley
Elbow / Carl A. Germann and Brook M. Goddard
Upper arm / Casey Glass
Shoulder / Adnan Hussain and Sanjeev Malik
Pelvis / Hany Y. Atallah
Hip / Gregory W. Hendey
Thigh / Rachel R. Bengtzen and Alexander P. Skog
Knee / Michael C. Bond
Leg / Adriana Segura Olson, George Chiampas, and Jacob Stelter
Ankle / Moira Davenport and Madison Galasso
Foot / Dennis Hanlon and Christopher Morris.

Summary: The treatment of humeral fractures is a complex issue and the source of considerable controversy. In the case of fractures of the proximal humerus, early range of motion is the main aim of treatment. If a fracture modifies the anatomy or function of the glenohumeral and scapulothoracic joints, the surgeon must adhere meticulously to treatment principles in order to ensure a satisfactory outcome. Humeral shaft fractures are frequent, accounting for 1% to 3% of all fractures in adults; while excellent functional results have been reported with nonoperative management, open reduction and internal fixation is preferred in specific clinical settings. In contrast, intra-articular fractures of the distal humerus are frequently complex and full functional recovery is difficult to achieve. This volume clearly explains the concepts that are central to an understanding of humeral fractures from the proximal to the distal tip. Indications for different forms of treatment, including nonsurgical, are presented in detail, and all of the commonly used fixation techniques are described with the help of high-quality illustrations. Further important aspects such as complications, rehabilitation, and treatment of sequelae are also fully considered. This book will be an invaluable and comprehensive aid for all surgeons who treat humeral fractures.

Contents:
PART 1. Proximal humerus: 1. Main anatomy
2. Understanding the Fracture
3. Operating theatre setup
4. Closed reduction principles
5. Surgical Approaches
6. Percutaneous fixation: when and how
7. ORIF in three-/four-part fractures
8. Intramedullary nail rationale and surgical technique
9. Anatomical shoulder arthroplasty
10. Reverse total shoulder arthroplasty
11. Surgical neck fracture
12. The tuberosities
13. Malunions of the tuberosity
14. Nerve injuries
15. Fracture dislocations
16. Treatment of the sequelae
17. Conservative treatment
PART 2. The diaphysis: 18. Surgical anatomy
19. Radial palsy and humerus fractures
20. Internal Fixation: plate or IM Nail
21. External fixation
22. Periprosthetic fracture
PART 3. Distal Humerus: 23. Surgical anatomy
24. Surgical approaches and fracture pattern
25. Internal fixation principles
26. Prosthesis
27. External fixation when and how
28. Malunion and non union
29. Terrible triad.

Summary: This book describes a streamlined version of vestibular rehabilitation therapy (VRT), an exercise-based approach that is of proven value in the treatment of vertigo and dizziness. This simplified form of VRT is intended for use in primary healthcare facilities. As Dr. Han had practiced martial art and ballet, he could pick out necessary movements from those art forms. The selected movements were used to make the VRT exercises. The opening part describes the indications for and the principles of VRT and provides general information on key exercises. The role of VRT in patients with central dizziness is then discussed. The remainder of the book offers clear, precise guidance on the exercises used in simplified VRT, covering general exercises, gaze stability exercises, postural stability exercises, and habituation exercises. The text is supported by numerous photographs that will help both clinicians and patients to implement the exercises correctly and effectively.

Contents:
Vestibular Rehabilitation Therapy: Review of Indications, Mechanisms, and Key Exercises
Vestibular Rehabilitation in Central Dizziness
Implementing the exercises.

Summary: This book provides a clear, concise and easy to understand guide to the diagnosis and management of strabismus. Throughout the text, a practical approach to examining, diagnosing and treating patients with strabismus is utilised, supported with case studies in the form of patient photographs and ocular motility videos. Flowcharts and tables are included, together with evidence based management plans and suggestions for further reading. Simplifying Strabismus: A Practical Approach to Diagnosis and Management is aimed at optometrists, junior and senior ophthalmologists, as well as any medical professional wishing to improve their knowledge of strabismus. -- Provided by publisher.

Contents:
Making sense of strabismus
Anatomy of the extraocular muscles
Applied physiology of eye movements
Examining a patient with strabismus
Orthoptic assessment of a patient with strabismus
Concomitant strabismus
Paralytic strabismus
Supranuclear disorders
Alphabet patterns in strabismus
Strabismus in systemic disease
Other forms of incomitant strabismus
Surgical and non-surgical treatment of strabismus.

Summary: This book focuses on evidence-based standards for simulation in nursing education. The foundational principle of simulation excellence and its relevance to nursing is defined and infuses throughout the book. It also discusses necessary components for quality simulation from development to implementation. These areas include (but are not limited to): theoretical background, accreditation and approval standards, the simulation environment, developing and implementing simulations, and debriefing. These subject areas are approached following a thorough review of the literature and current practices identified from the International Nursing Association for Clinical Simulation and Learning (INACSL), Society for Simulation in Healthcare (SSH), National League for Nursing (NLN) and State Boards of Nursing. This quick reference title will become the best practice standards for simulation excellence in nursing education.

Contents:
Chapter 1: Simulation in Nursing Education
Chapter 2: Standards in Simulation
Chapter 3: Simulation Environments
Chapter 4: Developing Simulations
Chapter 5: Implementing Simulations
Chapter 6: Putting It All Together.

Contents:
1 Introduction
Part I
2 Early Examples of Simulation in Training and Healthcare
3 Simulation in Medical Science
Part II
4 Simulation in Obstetrics and Midwifery
Part III
5 Simulators and Teaching Aids Used in Teaching Medicine
6 Simulation in Surgery
7 Simulation in Oto-, Rhino-, and Laryngology
8 Simulation in the Treatment of Eye Disorders
9 Simulation in Nursing
10 Simulation and Teaching in Resuscitation and Trauma Management
11 Simulation in Dentistry and Dental Hygiene
Index.

Summary: Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjögren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.

Summary: Single-access laparoscopic surgery (SALS), performed using a single transumbilical access, has recently proved to bring advantages over other forms of laparoscopic surgery due to the reduction in the number of incisions and the consequent decrease in morbidity, less blood loss and postoperative pain. Furthermore, cosmesis may be improved because incision within the umbilicus renders surgery virtually scarless. Nevertheless, as with all new surgical concepts, questions may be raised regarding safety, usefulness, and appropriateness. This book analyzes the use of SALS for different indications and abdominal surgical procedures based on a careful literature review of the experience of the most important surgical teams employing this approach and also the authors' personal observations. The coverage is broad, encompassing, for example, the role of SALS in appendectomy, repair of abdominal wall defects, cholecystectomy, gastric surgery, nephrectomy, splenectomy, hemicolectomy, and pancreatic, liver, and gynecological surgery. Resident surgeons specializing in laparoscopy, researchers, and related healthcare professionals will find Single-Access Laparoscopic Surgery to be an invaluable source of information in an area which deserves to receive detailed attention.

Contents:
Foreword
Preface
1.Introduction: From Multiport Laparoscopic Surgery to Single Port Laparoscopic Surgery
2.SingleAccess Laparoscopic Appendectomy
3.Single-access Laparoscopic Abdominal Wall Defect Repair
4.Single-access Laparoscopic Cholecystectomy
5.Single-access Laparoscopic Surgery for Obesity
6.Single-access Laparoscopic Approach for Gastric Surgery (Hiatal Hernia Repair and Gastric Resections)
7.Single-access Laparoscopic Splenectomy
8.Single-access Laparoscopic Right Hemicolectomy
9.Single-access Laparoscopic Left Hemicolectomy
10.Single-access Laparoscopic Rectal Anterior Resection
11.Single-access Laparoscopic Approach for Pancreatic Surgery
12.Single-access Laparoscopic Liver Resections
13.Single-access Laparoscopic Approach for Gynecological Surgery
14.Single-access Robotic Surgery.

Contents:
1. Can the single cell make biomedicine different?
2. Automated single-cell analysis and isolation system: a paradigm shift in cell screening methods for bio-medicines
3. Single-cell non-coding RNA in embryonic development
4. High throughput single cell RNA sequencing, bioinformatics analysis and applications
5. Circulating tumor cells: the importance of single cell analysis
6. Super-resolution fluorescence microscopy for single cell imaging
7. Single cell proteomics for molecular targets in lung cancer: high-dimensional data acquistion and analysis
8. Therapeutic antibody discovery in infectious diseases using single-cell analysis
9. Single cell genetics and epigenetics in early embryo: from oocyte to blastocyst
10. The potential roles and advantages of single cell sequencing in the diagnosis and treatment of hematological malignancies
11. Application of single cell sequencing in cancer
12. Emergence of bias during the synthesis and amplification of cDNA for scRNA-seq
13. Detection and application of RNA editing in cancer
14. Is pooled CRISPR-screening the dawn of a new era for functional genomics
15. Roles of single cell systems biomedicine in lung diseases
16. The significance of single-cell biomedicine in stem cells.

Contents:
Single-cell western blotting
A microfluidic device for immunoassay-based protein analysis of single E. coli bacteria
Enzyme-linked immunospot (ELISpot) for single-cell analysis
Photocleavable DNA barcoding antibodies for multiplexed protein analysis in single cells
Genome-wide analysis of protein and mRNA copy numbers in single escherichia coli cells with single-molecule sensitivity
Microfluidic flow cytometry for single-cell protein analysis
Microfluidic image cytometry for single-cell phenotyping of human pluripotent stem cells
Characterizing phenotypes and signaling networks of single human cells by mass cytometry
Multiplexed peptide-MHC tetramer staining with mass cytometry
Imaging and mapping of tissue constituents at the single-call level using MALDI MSI and quantitative laser scanning cytometry
SPLIFF: A single-cell method to map protein-protein interactions in time and space
Microfluidic proximity ligation assay for profiling signaling networks with single-cell resolution
Dynamics and interactions of individual proteins in the membrane of single, living cells
Microfluidics-enabled enzyme activity measurement in single cells
Microfluidic chemical cytometry for enzyme assays of single cells
Quantitative detection of nucleocytoplasmic transport of native proteins in single cells.

Summary: With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.

Contents:
Values of single-cell sequencing and methylation in molecular diagnosis and therapy
Single-cell sequencing in human diseases
Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application
DNA Methylation in pulmonary fibrosis
Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases
Research advances on DNA methylation in idiopathic pulmonary fibrosis
DNA Methylation in Chronic Obstructive Pulmonary Disease
Single cell sequencing: a new dimension in cancer diagnosis
The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers
Clinical Significance of P16 Gene Methylation in Lung Cancer
Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas
Single Cell Sequencing in GU Malignancies
PI3K Isoform-Selective Inhibitors in Cancer
Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases
Single-cell sequencing in human genital infections
PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease
Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells.

Summary: The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author?s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

Summary: Single Incision Laparoscopic and Transanal Colorectal Surgery provide a comprehensive and state-of-the art review of single incision laparoscopic and transanal colorectal surgery. The text concentrates on surgical techniques and tricks in single incision laparoscopic and transanal surgery with detailed descriptions of the techniques, as well as indications and limitations of the procedures. The newly available evidence on these procedures is emphasized and all procedures are richly illustrated with diagrams and photos. Written by experts in their fields, Single Incision Laparoscopic and Transanal Colorectal Surgery is a valuable resource for general surgeons, colon and rectal surgeons, laparoscopic GI surgeons, surgical residents and fellows in training interested in these two rapidly developing fields in colorectal surgery.

Contents:
Platforms and Instruments (principles of single incision laparoscopic colorectal surgery, available platforms and instruments)
Single Incision Laparoscopic Right Colectomy
Single Incision Laparoscopic Left Colectomy
SILS Total Colectomy and Proctocolectomy with Ileal Pouch-Anal Anastomosis (IPAA)
Low Anterior Resection and Total Mesorectal Excision
Tricks and Routes to Success
Robotic Single Port Colorectal Surgery
Current Evidence for Single Incision Laparoscopic Colectomy
Local Excision for Low Rectal Cancer: From Mucosectomy to Endolumen Loco-Regional Resection: Tips And Tricks
Hybrid NOTES Colectomy for Left-sided Colonic Tumors
Transanal Endoluminal Total Mesorectal Resection (Tetmr) by Transanal Endoscopic Microsurgery
Transanal Excision: Development, Technique and Evidence.

Contents:
Chapter 1. Direct fluorescent imaging of translocation and unwinding by individual DNA helicases
Chapter 2. Single-molecule imaging with one color fluorescence
Chapter 3. Measuring membrane protein dimerization equilibrium in lipid bilayers by single-molecule fluorescence microsopy
Chapter 4. Fluorescent labeling of proteins in whole cell extracts for single-molecule imaging
Chapter 5. Quantifying the assembly of multicomponent molecular machines by single-molecule total internal reflection fluorescence microscopy
Chapter 6. How to measure separations and angles between intramolecular fluorescent markers
Chapter 7. Precisely and accurately inferring single-molecule rate constants
Chapter 8. Quantification of functional dynamics of membrane proteins reconstituted in nanodiscs membranes by single turnover functional readout
Chapter 9. Putting Humpty-Dumpty together: clustering the functional dynamics of single biomolecular machines such as the splicosome
Chapter 10. Single-molecule FRET to measure conformational dynamics of DNA mismatch repair proteins
Chapter 11. Single-molecule confocal FRET microscopy to dissect conformational changes in the catalytic cycle of DNA topoisomerases
Chapter 12. Probing the conformational landscape of DNA polymerases using diffusion-based single-molecule FRET
Chapter 13. Methods for investigating DNA accessibility with single nucleosomes
Chapter 14. Single-molecule fluorescence studies of fast protein folding
Chapter 15. Single-molecule multicolor FRET assay for studying structural dynamics of biomolecules
Chapter 16. A multicolor single-molecule FRET approach to study protein dynamics and interactions simultaneously
Chapter 17. Interferometric scattering microscopy for the study of molecular motors
Chapter 18. Enzyme kinetics in femtoliter arrays
Author index
Subject index.

Contents:
1. The evolution of robotic single-port dedicated platforms / Riccardo Autorino, Christopher Bednarz, Fairleigh Reeves and Prokar Dasgupta
2. Applications of single-port robotic platforms in urology: an overview / Marcio Covas Moschovas and Vipul Patel
3. Single-port robot-assisted radical prostatectomy: transperitoneal versus extraperitoneal approach / Grace Chen and Simone Crivellaro
4. The re-discovery of alternative access to the pelvic fossa: the role of the single-port robotic platform / Juan Garisto, Venkat M. Ramakrishnan, Riccardo Bertolo and Jihad Kaouk
5. The evolution of single-port robot-assisted transperineal radical prostatectomy / Riccardo Bertolo, Juan Garisto and Jihad Kaouk
6. Robotic single-port surgery for kidney and upper urinary tract cancers / Paul Kogan and Ronney Abaza
7. Robot-assisted single-port radical cystectomy and intracorporeal urinary diversion / Fahad Sheckley, Michelle Kruse, Mubashir Billah, Juan Garisto and Mutahar Ahmed
8. Single-port robotic ureteral reconstruction / Nathan Cheng and Michael Stifelman
9. Single-port robotic surgery for kidney transplantation and autotransplantation / Alireza Aminsharifi, Mahmoud Abou Zeinab and Jihad Kaouk
10. Comparison of perioperative outcomes and costs between single-port and standard multiport robot-assisted surgeries in urology / Shirley L. Wang, Andrew T. Gabrielson, Phillip M. Pierorazio and Mohamad E. Allaf
11. Future perspectives: natural orifice transluminal endoscopic surgery / Alireza Aminsharifi, Riccardo Bertolo, Christian Huge and Wesley M. White.

Summary: This book reviews the standard surgical, radiotherapeutic, and systemic management of sinonasal and skull base tumors. It provides up-to-date information on epidemiology, diagnostic modalities, molecular biology, staging, treatment complications, principles of supportive care, and current controversies. Sinonasal and skull base tumors display histologic and anatomic heterogeneity, as well as wide variation in clinical behavior. Accordingly, they pose significant diagnostic and treatment challenges. A multidisciplinary approach offers the best chance of a successful outcome. In addition to documenting in detail the currently accepted management approaches, this book sheds light on various promising novel therapeutic strategies. Sinonasal and Skull Base Malignancies is an invaluable reference for all specialists involved in treating these tumors, including otolaryngologists, head and neck surgeons, reconstructive surgeons, medical and radiation oncologists, neuroradiologists, specialized head and neck pathologists, prosthodontists, and speech and swallow therapists.

Contents:
The Etiology and Epidemiology of Sinonasal Malignancies
Radiology and Diagnostic Approaches to Sinonasal Malignancies and Skull Base Tumors
The Pathology of Common Sinonasal and Skull Base Malignancies
Open Approaches to Sinonasal Tumors
Reconstruction and Rehabilitation after Surgical Ablation of the Paranasal Sinuses
Endoscopic Resection of Sinonasal Tumors
Endoscopic Reconstruction of the Skull Base
Radiation Therapy for Sinonasal and Skull Base Tumors
Theroleofsystemictherapyandtargetedapproaches for the treatment of sinonasal malignancies,- Complications of Surgical Management of Skull Base and Sinonasal Malignancies
Supportive care for patients with sinonasal and skull base tumors
Rare Sinonasal and Skull Base Tumors.

Summary: Placement of endosseous implants in the posterior maxilla is often difficult because of a lack of supporting bone. Sinus augmentation procedures have therefore been extensively used for the treatment of the edentulous atrophic posterior maxilla prior to implant placement. This book describes in detail the most widely used sinus grafting techniques as well as some innovative variations, with full coverage of both lateral and crestal approaches. A key aim is to assist the practitioner in selecting the appropriate sinus grafting technique based on the evaluation of a number of parameters that are described in detail and codified in a simple and practical way. Up-to-date information is also provided on grafting materials and on potential complications of sinus augmentation procedures and their treatment.

Contents:
Introduction and Biologic Basis of Sinus Grafting
Anatomical and Physiological Considerations for Sinus Augmentation
Update on Grafting Materials
Lateral Sinus Grafting Approach
Crestal Sinus Grafting Approach
Guidelines for Optimal Treatment
Complications
Conclusions.

Summary: This volume serves as a comprehensive and useful guide for ENT and allergy physicians in the recognition, diagnosis, and treatment of patients who suffer from sinus headaches and migraines. The text reviews key issues such as identification and management of migraine, and appropriate surgical and nonsurgical treatment that is often not part of ENT or allergy resident training. With 20% of women and 6% of men having migraines (only 50% recognized) this text also serves to expand management options to physicians already medically or surgically treating sinuses or seeing cosmetic patients with head and neck concerns. Other forms of intervention in migraineurs, such as surgery, Botulinum Toxin injections and adjunctive and integrative therapy, are covered. Sinus Headache, Migraine, and the Otolaryngologist will be an invaluable resource for ENT and allergy specialists, and any physician or medical professional with an interest in sinus headache or migraine.

Contents:
Sinus Headache, Migraine, and the Otolaryngologist: an Introduction
Anatomy and Pathophysiology of Migraine
Differential Diagnosis and Workup of the Headache Patient: Should I Order a Scan?
Pharmacological Management of Migraine
Botulinum Toxin for Migraine Headaches
Sinus Headache and Rhinogenic Headache
Allergic Rhinitis and Migraine Headache
Vestibular Migraine
Migraine Co-Morbidities
Surgery for Migraine: An Evidence-Based Review
Adjunctive and Integrative Therapy in Migraine Management.

Contents:
An introductory snapshot
In the beginning
London and the Great Windmill Street School
Anatomy of the expression of emotions
Behind the glories of war
Swings and roundabouts
In and out of the central nervous system
The organization of the nervous system
Clinical observations on the nervous system
For God and country
New classrooms : old struggles
The ebbing tide
To each his due.

Contents:
Synthesis and conjugation of small interfering ribonucleic neutral SiRNNs / Alexander S. Hamil and Steven F. Dowdy - - Liver-targeted SiRNA delivery using biodegradable poly(amide) polymer conjugates / Stephanie E. Barrett and Erin N. Guidry
PepFect6 mediated SiRNA delivery into organotypic cultures / Suvarna Dash-Wagh, Ülo Langel, and Mats Ulfendahl
Highly efficient SiRNA delivery mediated by cationic helical polypeptides and polypeptide-based nanosystems / Lichen Yin, Nan Zheng, and Jianjun Cheng
Disulfide-bridged cleavable PEGylation of poly- L -lysine for SiRNA delivery / Min Tang ... [et al.]
Preparation of a cyclic RGD : modified liposomal SiRNA formulation for use in active targeting to tumor and tumor endothelial cells / Yu Sakurai, Tomoya Hada, and Hideyoshi Harashima
Multifunctional envelope-type nano device containing a pH-sensitive cationic lipid for efficient delivery of short interfering RNA to hepatocytes in vivo / Yusuke Sato, Hideyoshi Harashima, and Michinori Kohara
Bioreducible poly (beta-amino ester)s for intracellular delivery of SiRNA / Kristen L. Kozielski and Jordan J. Green
Preparation of polyion complex micelles using block copolymers for SiRNA delivery / Hyun Jin Kim ... [et al.]
Delivery of small interfering RNAs to cells via exosomes / Jessica Wahlgren ... [et al.]
Dendrimer nanovectors for SiRNA delivery / Xiaoxuan Liu and Ling Peng
Chitosan nanoparticles for SiRNA delivery in vitro / Héloïse Ragelle ... [et al.]
Non-covalently functionalized of single-walled carbon nanotubes by DSPE-PEG-PEI for SiRNA delivery / King Sun Siu ... [et al.]
SiRNA in vivo-targeted delivery to murine dendritic cells by oral administration of recombinant yeast / Kun Xu ... [et al.]
TLR9-targeted SiRNA delivery in vivo / Dewan Md Sakib Hossain ... [et al.]
Aptamer-MiRNA conjugates for cancer cell-targeted delivery / Carla L. Esposito, Silvia Catuogno, and Vittorio de Franciscis
Method for confirming cytoplasmic delivery of RNA aptamers / David D. Dickey ... [et al.]
Hapten-binding bispecific antibodies for the targeted delivery of SiRNA and SiRNA-containing nanoparticles / Irmgard S. Thorey ... [et al.]
Stable delivery of CCR5-directed shRNA into human primary peripheral blood mononuclear cells and hematopoietic stem/progenitor cells via a lentiviral vector / Saki Shimizu, Swati Seth Yadav, and Dong Sung An
Hepatic delivery of artificial micro RNAs using helper- dependent adenoviral vectors / Carol Crowther, Betty Mowa, and Patrick Arbuthnot
Intravascular AAV9 administration for delivering RNA silencing constructs to the CNS and periphery / Brett D. Dufour and Jodi L. McBride
Efficient gene suppression in dorsal root ganglia and spinal cord using adeno-associated virus vectors encoding short-hairpin RNA / Mitsuhiro Enomoto ... [et al.]
Synthetic SiRNA delivery : progress and prospects / Thomas C. Roberts ... [et al.].

Summary: This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.

Contents:
Intro; Supervisor's Foreword; Abstract; Preface; Acknowledgements; Contents; List of Contributors; Acronyms and Abbreviations; List of Figures; List of Tables; 1 Introduction; 1.1 Premature Aging and Genomic Instability; 1.1.1 Chronological Aging and Premature Aging; 1.1.2 A Brief Background of Progeroid Syndromes; 1.1.3 Genomic Instability and Premature Aging; 1.2 Lamins and Laminopathies; 1.2.1 The Nuclear Lamins; 1.2.2 A Brief Outlook of Laminopathies; 1.2.3 Hutchinson-Gilford Progeria Syndrome (HGPS); 1.2.4 Atypical HGPS Conditions; 1.3 Role of Sirtuins in Premature Aging 1.3.1 Sirtuins ... At a Glance1.3.2 Sirt1; 1.3.3 Sirt2; 1.3.4 Sirt3; 1.3.5 Sirt4; 1.3.6 Sirt5; 1.3.7 Sirt6; 1.3.8 Sirt7; 1.4 An Overview of SIRT6; 1.4.1 Structure and Localization of SIRT6; 1.4.2 Diverse Functions of SIRT6; 1.4.3 Post-translational Modifications of SIRT6; 1.4.4 Perspectives; 1.5
p53: In a Nutshell; 1.5.1 Domains of p53 and Their Associated Functions; 1.5.2 Mechanisms of p53 Activation and Regulation; 1.5.3 Perspectives; 1.6 Hypotheses and Objectives of Study; 1.6.1 Hypothesis I: A Potential Interlinkage Between Lamins and SIRT6 in DNA Damage Repair and Premature Aging 1.6.2 Hypothesis II: A Potential Functional Interlinkage Between SIRT6 and P53 in Accelerated Cellular Senescence and Premature Aging1.6.3 Hypothesis III: Other Post-translational Modifications of SIRT6 with Regulatory Roles in DNA Damage Repair Process; References; 2 Materials and Methods; 2.1 Materials; 2.1.1 Cell Lines; 2.1.2 Mouse Lines; 2.1.3 Constructs; 2.1.4 Antibodies; 2.1.5 Reagents; 2.1.6 Primers; 2.2 Methods; 2.2.1 Cell Culture, Transfections and Treatment with Reagents; 2.2.2 Mouse Embryonic Fibroblast (MEF) Collection; 2.2.3 Genotyping of Tissues from Mice 2.2.18 Isolation of Bone Marrow Stromal Cells, and Cells from Thymus and Spleen2.2.19 Immunostaining for Fluorescence-Activated Cell Sorting (FACS) Analysis; 2.2.20 Annexin-V Staining; 2.2.21 Statistical Analysis; References; 3 Results-I. Lamin A is an Endogenous Activator of SIRT6 in DNA Damage Repair Process; 3.1 Introduction; 3.2 Results; 3.2.1 Lamin A is a Direct Interacting Partner of SIRT6; 3.2.2 The Core Domain of SIRT6 Plays a Critical Role in Interacting with Lamin A; 3.2.3 The C-Terminus of Lamin A Dictates Its Binding with SIRT6; 3.2.4 Lamin A Enhances SIRT6 Deacetylase Activity

Contents:
1. Biochemistry and enzymology of sirtuins
2. NAD as a pharmacological tool to boost sirtuin activity
3. Protein lysine acylation: abundance, dynamics and function
4. SIRT1 in metabolic health and disease
5. Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function
6. SIRT5 reveals novel enzymatic activities of sirtuins
7. Diverse roles of SIRT6 in mammalian healthspan and logevity
8. Sirtuins in cancer, emerging role as modulators of metabolic reprogramming
9. Sirtuins as metabolic modulators of muscle plasticity
10. Sirtuins and aging
11. Sirtuins and the circadian clock: epigenetic and metabolic crosstalk
12. Sirtuin activation by small molecules
13. Sirtuins: a future perspective
Index.

Contents:
How FlAsH got its dparkle : historical recollections of the biarsenical-tetracysteine tag / B. Albert Griffin, Stephen R. Adams, and Roger Y. Tsien - - Site-specific protein labeling in the pharmaceutical industry : experiences from novartis drug discovery / Lukas Leder
Getting across the cell membrane : an overview for small molecules, peptides, and proteins / Nicole J. Yang and Marlon J. Hinner
Considerations and protocols for the synthesis of custom protein labeling probes / Ivan R. Corrêa Jr.
2-Cyanobenzothiazole (CBT) condensation for site- specific labeling of proteins at the terminal cysteine residues / Lina Cui and Jianghong Rao
Fluorescent labeling for patch-clamp fluorometry (PCF) measurements of real-time protein motion in ion channels / Thomas K. Berger and Ehud Y. Isacoff
Fluorescent labeling of SNAP-tagged proteins in cells / Gražvydas Lukinavičius, Luc Reymond, and Kai Johnsson
Halotag technology for specific and covalent labeling of fusion proteins / Hélène A. Benink and Marjeta Urh
Ligation of synthetic peptides to proteins using semisynthetic protein trans-splicing / Julian C.J. Matern ... [et al.]
Chemical-tag labeling of proteins using fully recombinant split inteins / Anne-Lena Bachmann ... [et al.]
Phage selection assisted by Sfp phosphopantetheinyl transferase-catalyzed site-specific protein labeling / Bo Zhao ... [et al.]
Site-specific biotinylation of purified proteins using BirA / Michael Fairhead and Mark Howarth
Site-specific labeling of proteins via sortase : protocols for the molecular biologist / Maximilian Wei-Lin Popp
BONCAT: metabolic labeling, click chemistry, and affinity purification of newly synthesized proteomes / Peter Landgraf, Elmer R. Antileo, Erin M. Schuman, and Daniela C. Dieterich
Genetic encoding of unnatural amino acids for labeling proteins / Kathrin Lang , Lloyd Davis, and Jason W. Chin
Labeling proteins by affinity-guided DMAP chemistry / Tomonori Tamura and Itaru Hamachi
Ligand-directed tosyl chemistry for selective native protein labeling in vitro, in cells, and in vivo / Shinya Tsukiji and Itaru Hamachi.

Summary: This book fills the gap in the literature on nursing theories by presenting the background information on situation specific theories such as philosophical bases and current status of situation specific theories and providing a collection of situation specific theories that have been developed. It provides specific guidelines for nursing research and practice, essentials for PhD and DNP students to complete the requirements for their degrees (e.g., dissertation, QI project). In addition, this book can be used in theory courses in other graduate nursing programs that require theoretical bases for their comprehensive exam or scholarly project (e.g., MSN, NP). Throughout nursing history, nursing theories have evolved within the contexts of changing and emerging theoretical needs of nursing discipline. Subsequently, several different types of nursing theories have been proposed, developed, and used in nursing education, research, and practice. Situation specific theories could be easily adopted and used in nursing practice and research due to their foci on specific populations or particular fields. Since situation specific theories were firstly proposed in 1990s, they became a major part of nursing theories in the past two decades, making this book appeals to all levels of nursing students.

Summary: Despite food being safer, more affordable and more available than at any time in human history, consumers are increasingly skeptical and critical of today?s food system. In Size Matters, Charlie Arnot provides thought provoking insight into how the food system lost consumer trust, what can be done to restore it, and the remarkable changes taking place on farms and in food companies, supermarkets and restaurants every day as technology and consumer demand drive radical change. The very systems and technologies that are mistrusted by consumers are driving a revolution that empowers individual consumers to find the perfect recipe of taste and nutrition to meet their specific needs and desires. Size Matters pulls back the curtain to examine the irony, competing priorities and new realities that shape today's food system.

Contents:
Chapter1: Sowing the Seeds of Distrust
Chapter2: Social License Revoked
Chapter3: From A & P to Omni Shopping
Chapter4: From Famine to Feast
Chapter5: How to Make Money by Doing What's Right
Chapter6: Brands as Agents of Change
Chapter7: Military, Social Media and Meal Time
Chapter8: Dinner Without Dogma.

Summary: Sjögren's Syndrome summarises current understanding of the pathogenesis of the disease, including advances in the genetics, disease mechanisms, clinical diagnosis and assessment, secondary Sjögren's syndrome, and the role of laboratory investigations and imaging.

Contents:
Introduction : history of Sjögren's syndrome
Clinical features
Management of Sjögren's syndrome
Classification criteria for Sjögren's syndrome
Imaging procedures useful for the diagnosis of Sjögren's syndrome : abnormalities of the major salivary glands
Sjögren's syndrome--associated lymphoma
Spontaneous and inducible animal models of Sjögren's syndrome
Genetics, genomics, gene expression profiling, and epigenetics in Sjögren's syndrome
Autoantigens and autoantibodies in the pathogenesis of Sjögren's syndrome
Sjögren's syndrome and environmental factors
Histology of Sjögren's syndrome
Glandular epithelium : innocent bystander or leading actor?
T cells in the pathogenesis of Sjögren's syndrome : more than just Th1 and Th2
B lymphocytes in primary Sjögren's syndrome
Cytokines, chemokines, and the innate immune system in Sjögren's syndrome
Autoantibodies and autoantigens in Sjögren's syndrome
Outcome measures in Sjögren's syndrome and perspectives in clinical trial design
Novel therapeutic strategies in Sjögren's syndrome : b-cell targeting
Novel therapeutic strategies in Sjögren's syndrome : t-cell targeting
New biological avenues for Sjögren's syndrome.

Summary: This book provides a thorough update on Sjögren's syndrome (SS) and its adverse impacts on oral health. The opening section focuses on the clinical and laboratory characteristics of SS and its current management. Here, readers will find information on diagnostic criteria, pharmacotherapy, dental management, and the importance of saliva in oral health and SS. Attention then turns to the immunopathogenesis of SS, which includes the mechanisms of secretory dysfunction, myoepithelial cell functions in salivary gland physiology and disease, dysregulated innate and adaptive immunity, and B-cell expansion and neoplasia. The final section details important advances in SS diagnosis and therapy. The differential diagnoses of recurrent glandular swelling, glandular irrigation and sialendoscopy, and salivary gland ultrasound for SS in children are explained, along with the pharmacological management for SS, clinical care for dry eyes, and gene therapy. This book will be of interest to not only dental practitioners and researchers but also rheumatologists and pathologists.

Contents:
Clinical Characteristics of SS and Current Management: Characteristics of SS, Pharmacotherapy and Dental Management
Saliva and Its Importance in SS
Efficacy of Sialoendoscopy in SS
Dysautonomia in SS and Oral Complications. Immunopathogenesis of SS: Mechanisms of Secretory Dysfunction in SS
Dysregulation of Innate Immunity and Oral Health.-Dysregulation of Adaptive Immunity and Oral Health. Improved SS Diagnosis and Therapeutics: Recurrent vs. Persistent Salivary Gland Swelling in Differential Diagnosis of SS
Salivary Gland Ultrasound Sonography of SS and Juvenile SS
Sialometry: The importance of Calibration
Gene Therapy in SS for Restoration of Secretory Dysfunction.

Summary: This book answers questions about the critical role of ultrasound in the management of patients with Sjogrens syndrome. It also covers developments rheumatologists can foresee in performing a biopsy of the parotid gland. Each chapter is authored by experts on this condition, emphasizing the extent of current understanding and dealing with unanswered challenges and pitfalls. Topics such as modern imaging techniques like ultrasound and MRI and their importance are given particular focus in this book; practitioners are increasingly using imaging techniques to refine diagnosis and guide clinical management. Additionally, as a significant emerging point of interest in the field, biopsy of the major salivary glands, particularly ultrasound-guided procedures, receives extra attention within the text. The book also includes a chapter that deals with future directions and will also review the challenges patients face with unmanaged Sjogrens syndrome. Comprehensive and concise, Sjogrens Syndrome and the Salivary Glands provides a balanced overview between the chapters and ensure homogeneity of the terminology.

Contents:
Introduction
Epidemiology of Sjogrens syndrome
The variable clinical presentation of Sjogrens syndrome
Diagnostic and classification criteria of Sjogrens syndrome
On the complex pathogenesis of Sjogrens syndrome: epigenetics and epithelial cells
On the complex pathogenesis of Sjogrens syndrome: environmental factors and cells of the innate and adaptive immune system
Juvenile Sjogrens syndrome
Anatomy and histology of the salivary glands
Sonoanatomy of the major salivary glands
Imaging of Sjogrens syndrome, with special reference to ultrasound
Towards a scientific validation of ultrasound for Sjogrens syndrome
Ultrasonographic scoring systems a systematic review
Biopsy of the minor salivary glands in Sjogrens syndrome
Biopsy of the major salivary glands in Sjogrens syndrome, with special reference to B cell proliferation.

Summary: Sjögren's Syndrome is slowly being recognised as one of the most common auto-immune diseases, and considered pivotal in the spectrum of auto-immune disorders. Sjögren's Syndrome in Clinical Practice is a unique, concise book which explores important insights into Sjögren's links with other conditions and devotes itself to shedding new light on this disease. Aimed at young medics but also suitable for the informed lay reader, physicians and pharma, Sjögren's Syndrome in Clinical Practice will help with the diagnosis and treatment of this increasingly recognised disorder.

Contents:
Introduction
Eyes
Mouth and Salivary Glands
Lungs
Skin
Gut
Bladder, Vagina, Kidney
The Nervous System
Joints, Tendons, Muscles
Sjögren's and Lymphoma
Sjögren's Overlaps
General Treatment
Drug Treatment
Diagnosis I: Blood Tests
Diagnosis II: Other Tests
Causes of Sjögrens.

Contents:
Overview of Skeletal Development
Overview of Skeletal Repair (Fracture Healing and Its Assessment)
Generation of Closed Transverse Fractures in Small Animals
The Murine Femoral Bone Graft Model and a Semi-Automated Histomorphometric Analysis Tool
Surgical Induction of Posttraumatic Osteoarthirits
A Mouse Model of Flexor Tendon Repair
Cartilage Explant Cultures
Renal Capsule Transplantations to Assay Skeletal Angiogenesis
Whole Mount Skeletal Staining
Tips and Techniques for Processing and Sectioning Undecalcified Murine Bone Specimens
Preparation of Thin Sections from Non-fixed and Undecalcified Hard Tissues Using Kawamoto's Film Method (2012)
Demineralized Murine Skeletal Histology
Beta-Galactosidase Staining in the Skeleton
Whole-Mount In Situ Hybridization on Murine Skeletogenic Tissues
Non-Radioactive In Situ Hybridization on Skeletal Tissue Sections
Radioactive In Situ Hybridization to Detect Gene Expression in Skeletal Tissue Sections
Proliferation Assays (BrdU and EdU) on Skeletal Tissue Sections
TUNEL Assay on Skeletal Tissue Sections to Detect Apoptosis
Analysis of Chondrogenesis Using Micromass Cultures of Limb Mesenchyme
Isolation and Culture of Murine Primary Chondrocytes
Bone Marrow Stromal Cell Assays : In Vitro and In Vivo
Isolation and Culture of Neonatal Mouse Calvarial Osteoblasts
RANKL-Based Osteoclastogenic Assays from Murine Bone Marrow Cells
Hematopoietic Stem Cell Cultures and Assays.

Summary: From the sternoclavicular joint to the distal phalanx, Skeletal Trauma of the Upper Extremity is a practical, one-volume resource covering all aspects of upper limb trauma and surgery. Comprehensive in scope, it features a multidisciplinary, step-by-step approach to evaluation and management, including concise background information and a detailed focus on practical points and surgical techniques. Written by global experts in traumatology, sports medicine, shoulder, elbow, and hand surgery, this richly illustrated guide brings you into the operating room with leaders in the field. Offers detailed, practical guidance from the originators and/or masters of each procedure, along with multiple, illustrated surgical technique descriptions. Includes pearls and pitfalls, preoperative evaluation and indications, surgical techniques, rehabilitation, and management of complications. Features tables and figures throughout that clearly demonstrate surgical tips and tricks. Identifies controversial topics and covers current challenges such as arthroscopic coracoclavicular/acromioclavicular joint reconstruction, reverse total shoulder arthroplasty for proximal humerus fracture, total elbow arthroplasty for fracture, interosseous membrane reconstruction of the forearm, and many more. Contains more than 500 high-quality illustrations, including anatomical and surgical illustrations, surgical photographs, ultrasounds, and x-rays. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Summary: With a focus on end-of-life discussion in aging and chronically ill populations, this book offers insight into the skill of communicating in complex and emotionally charged discussions. This text is written for all clinicians and professionals in the fields of healthcare and public health who are faced with questions of ethical deliberation when a patient's illness turns from chronic to terminal. This skill is required to manage care well in an age of advanced technology, and numerous autonomous choices. With a palliative care and ethics focus, the manuscript provides case studies illustrating issues which occur in the acuity and chronicity of end of life. Clear tools for clinicians, such as scripting and "the advance care planning video library" are included. The book focuses on the unique concept of outpatient ethics, including readmission prevention and shortened length of stay through good communication for clinicians who will be required to conduct this discussion with patients. The ethical undertone in this text provides a perfect opening for application in healthcare ethics classes, both in fields of public health and healthcare. Medical scholars and physicians, nurse practitioners and physician's assistants, as well as social workers, both in practice and training, will benefit from this text.

Contents:
Introduction to Daniel
Defining the patient population
Ethics and the medicalization of death
Ethics end-of-life cases
The skills of communicating clearly.

Summary: This book provides a practical and pragmatic guide to becoming a successful practitioner. It covers everthing from thinking and judgement to decision making, evidence-based practice and research skills, leadership and managemnt. It also guides the reader towards effective career advancement, getting their work noticed, and staying up to date in their field.--back cover.

Contents:
Introduction
Section 1: Thinking, judgement and decision skills for practice
Judgement and decision-making skills for practice / Priscilla Harries
Shared decision-making skills in practice / Edward A. S. Duncan
Doing reflective practice: being a reflective and resilient practitioner / Elizabeth Anne McKay
Section 2: Professional skills for practice
Assessment skills for practice / Susan Prior ; Nichola Duffy ; Edward A. S. Duncan
Activity analysis / Kirsty Forsyth
Goal setting in occupational therapy: a client-centred perspective / Lesley Scobbie ; Sally Boa
Therapeutic use of self: a model of the intentional relationship / Renne R. Taylor ; Jane Melton
Problem solving / Edward A. S. Duncan
Group skills for practice in occupational therapy / Sharan L. Schwartzberg ; Mary Alicia Barnes
Record and report writing / Lisa McGraw ; Jane Grant
Section 3: Evidence-based and research skills for practice
Finding and appraising the evidence / Edward A. S. Duncan ; M. Clare Taylor
Implementation science / Katrina Bannigan
Section 4: Leadership, supervision and management skills for practice
Improvement science in practice / Lianne McInally
Developing research skills in practice / Edward A.S. Duncan
Presentation and publication skills / Edward A. S. Duncan ; Allister Landrock ; Ann Landrock
Self-care and self-management / Katrina Bannigan
Leadership skills / Charles H. Christiansen
Practice education-Skills for students and educators / Stephen Isbel ; Thomas Bevitt ; Mon-Lin Ye ; Ted Brown
Clinical supervision skills / Jenny Strong ; Amy McKenzie
Professional use of social media / Edward A.S. Duncan.

Summary: This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance of detailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.

Contents:
Part 1 Basics in Rheumatology
1 History-Taking Skills in Rheumatology
2 Approach to Musculoskeletal Examination
3 Laboratory Interpretation of Rheumatic Diseases
4 Pharmacotherapy in Systemic Rheumatic Diseases
5 Radiology in Rheumatology
Part 2 Diagnostic approach to common medical problems in patients with rheumatic diseases
6 Low Back Pain
7 Pulmonary Manifestations of Connective Tissue Diseases
8 Nervous system and rheumatology
9 Diagnostic Approach to Proximal Myopathy
10 Bones and Rheumatology
11 Fever and Rheumatology
12 Thrombosis in Rheuamtological Diseases
13 The Blood in Rheumatology
14 Renal System and Rheumatology
15 Skin Manifestations of Rheumatological Diseases
16 Cardiovascular Diseases and Rheumatology
17 Gestational Rheumatology
18 Perioperative Management of Patients with Rheumatic Diseases
19 The Eye and Rheumatology
20 Vasculitis and Rheumatology
21 Diabetes and Rheumatology
22 Soft Tissue Rheumatic Disorders
23 Gastrointestinal System and Rheumatology
24 Pediatric Rheumatology
Part 3 Classification criteria and guidelines
25 Classification Criteria and Clinical Practice Guidelines for Rheumatic Diseases.

Summary: An era of global population aging is upon us. By 2030, one in eight people will be over age 65. Since women generally live longer than men, the health and welfare of postmenopausal women will become a significant public health concern. This book offers a comprehensive review of the life changes associated with menopause, both at the dermatological and physiological level (e.g., hormonal, immunological) and at the subcellular level. It critically examines the dermatological, biological, and clinical challenges to postmenopausal health and well-being and the current and emerging therapeutic interventions. The authors advocate a holistic approach, emphasizing the need to view the menopause as a life transition with various facets rather than as a series of distinct medical conditions to be managed. Our goal is to offer a comprehensive resource to the researchers, clinicians, physicians, and helping professions whose mission is to promote the health and well-being of women around the world.

Contents:
What is Menopause?
Skin and Menopause
Effect of Supplementations and Vitamins on Menopause
Hormonal Change and Therapy
Menopause and Genital
Menopause and Autoimmune Disease
Hotflahes
Other Therapy for Menopause
Sexual Decline
Menopause Tests
Menopause and Sleep
Menopause and Mental Effects
Menopause and Quality of Life
Menopause and cosmetic procedures.

Summary: This book summarizes the potent effect of ultraviolet radiation (UVR) on the photoaging and cancer formation. Skin is the largest human organ which continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. This protection can be compromised by the aging of the skin which ultimately promotes skin inflammation, impaired wound repair, and increased risk of skin cancer. The book entails mechanistic insights into the UVR-induced immunomodulation and DNA damage in the skin to delineate the pathogenesis, and develop novel ways for prevention of photoaging of the skin cells. It also elucidates the potential of nanotechnology in the treatment of skin cancer. Further, it discusses the bioinformatics approaches to understand the molecular mechanism of photoaging and cancer formation.

Contents:
Chapter 1. Skin anatomy & morphology
Chapter 2. Cellular & Molecular events: skin aging & cancer
Chapter 3. Human skin stem cell and aging
Chapter 4. UV-R induced skin damage: Skin againg & cancer
Chapter 5. UV-R induced immunomodulation :Skin aging & cancer
Chapter 6. UV-R and Role of Pigmentation in skin aging & cancer
Chapter 7. UV-R and Vitamin D synthesis
Chapter 8. UV-R induced melanin chemi-excitation in melanoma pathogenesis
Chapter 9. Future prospective of nanotechnology in skin cancer therapeutics
Chapter 10. Role of bioinformatics in understanding of molecular mechanism and prevention of skin cancer
Chapter 11. UV-R interaction with skin. Cases of study
Chapter 12. Monitoring the genotoxic potential of sunlight and DNA photoprotection of sunscreen.

Summary: This book describes the relationship of the skin with cardiovascular disease. It details the variety of genetic, autoimmune, metabolic and endocrine factors that link the two disciplines. Recognition of one sign or symptom in dermatology can lead to the investigation and discovery of an important related cardiac condition, the recognition of which is important to prevent cardiovascular complications. Similarly, a cardiac condition may be related to an underlying skin condition that requires treatment. Genetic examples of such instances included within the book include: pseudoxanthoma elasticum, epidermolysis bullosa with desmosome defects and plectin defects; Marfan syndrome; Autoimmune conditions include vasculitis, sarcoidosis, lupus; metabolic conditions include insulin resistance, eruptive xanthomas with hypertriglyceridemias and elevated cholesterol; endocrine disorders include thyroid acropachy with atrial fibrillation; insulin resistance with coronary artery disease and psoriasis or hidradenitis suppurativa. Skin and the Heart reviews the effects of genetic, autoimmune and endocrine diseases with connections between skin and heart. It is therefore a key reference for all practitioners and researchers working in both disciplines.

Contents:
I. Embryology. Embryology of the skin ; Embryology of the heart
II. Genetic diseases. Epidermolysis bullosa ; Cutaneous Manifestations of Aortic Disease ; Tuberous Sclerosis Complex: Skin and Heart: Pivotal Common and Early Signs ; Incontinentia pigmenti ; The Heart in Neurofibromatosis 1 ; Cardiocutaneous desmosomal disorders
III. Inflammatory diseases. Lupus erythematosus and other collagen diseases ; Vasculitis ; Behçet's Disease ; Kawasaki disease
IV. Infectious. COVID-19 ; Lyme disease ; Syphillis ; Viral conditions
V. Metabolic and endocrine diseases. Xanthomas and abnormalities of lipid metabolism and storage ; The skin and diabetes ; Lysosomal Storage Disorders: Fabry Disease ; Mastocytosis
VI. Drug reaction. Medication induced cardiotoxic and skin rections ; Cardiovascular side effects of medications for skin diseases ; The importance of cardiac assessment in the era of biologic therapies for psoriasis
VII. Erythoroderma and High output cardiac failure. Erythroderma and cardiac function
VIII. Miscellaneous. Disorders of fluid regulation ; Infantile hemangiomas and the heart ; Erdheim-Chester disease ; Cardiac Implantable Device Related Complications.

Contents:
Filaggrin and skin barrier function
Stratum Corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients
Importance of tight junctions in relation to skin barrier function
Antimicrobial peptides, infections and the skin barrier
Biological variation in skin barrier function: from A (atopic dermatitis) to X (xerosis)
Methods for the assessment of barrier function
In vivo raman confocal spectroscopy in the investigation of the skin barrier
Irritants and skin barrier function
Skin barrier function and allergens
Penetration through the skin barrier
Treatments improving skin barrier function
Standards for the protection of skin barrier function
The role of the skin barrier in occupational skin diseases
Wet work and barrier function
Saving the barrier by prevention.

Summary: The incidence of skin cancer continues to rise, as do the challenges physicians face in treating the growing population of skin cancer patients. Skin Cancer Management: A Practical Approach, 2nd edition addresses the spectrum of skin cancers from the precancerous to the inoperable. In this revised and updated edition, a wide selection of medical treatments and surgical procedures are described in detail and supplemented with an abundance of full-color figures. Numerous case studies help to illustrate the various techniques. .

Contents:
Biopsy Techniques and Interpretation
Topical Therapies for Nonmelanoma Skin Cancers
Chemical Peels for Precancerous Skin Lesions
Photodynamic Therapy
Intralesional and Perilesional Treatment of Skin Cancers
Electrodesiccation and Curettage
Cryosurgery
Optimizing Surgical Outcomes
Anxiolysis, Anesthesia, and Analgesia
Excision Techniques and Materials
Mohs Surgery
Principles of Cutaneous Flap Surgery
Techniques in Skin Grafting
Nail Surgery and Malignant Tumors of the Nail Unit
Practical Management of Melanoma
Skin Cancer in Skin of Color
Management of Skin Cancers in Solid Organ Transplant Recipients
Imaging of Head and Neck Skin Cancer
Radiation Oncology in Skin Cancer Treatment
When to Refer Out
Chemoprevention of Keratinocyte Carcinomas
Systemic Therapy for Locally Advanced and Metastatic Non-Melanoma Skin Cancer.

Contents:
Scope of the Problem
Anatomy of the Skin and Pathophysiology of Radiation Dermatitis
Types of Radiation-Related Skin Reactions
Skin Care Products Used During Radiation Therapy
Head and Neck Cancer
Thoracic Cancers
Breast Cancer
Gastrointestinal Cancer
Genitourinary Cancer
Gynecologic Cancer
Central Nervous System
Pediatrics
Sarcoma
Skin Cancer
Locally Advanced Cancers.

Summary: The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. However, some chemicals act directly on the skin including vesicants sulfur mustard and corrosive compounds such as strong acids or bases, and do not have to gain access to systemic circulation to cause extensive skin damage. Early and rapid skin decontamination is extremely important following exposure to chemical warfare agents and toxic industrial chemicals because it decreases serious skin damage to the patient and, potentially, their doctor. This multi-authored international text pulls together a century of decontamination research and helps the reader expedite solutions that will decrease morbidity and mortality. Complete with dozens of hiqh quality photographs and illustrations, Skin Decontamination aids industrial hygiene, dermatology, occupational physicians and those involved in the public health arena.

Contents:
Chapter 1. Isolated Human and Animal Stratum Corneum As a Partial Model for the 15 Steps of Percutaneous Absorption: Emphasizing Decontamination, Part I
Chapter 2. Isolated Human And Animal Stratum Corneum As A Partial Model For The 15 Steps Of Percutaneous Absorption: Emphasizing Decontamination Part II
Chapter 3. Recent Knowledge: Human/Animal Skin Decontamination
Chapter 4. The Decontamination of Chemically Contaminated Remains
Chapter 5. Effectiveness of Chemical, Biological, Radiological, and Nuclear (CBRN) Skin Decontaminants: Towards Tests Standardization
Chapter 6. Effects of Soap-Water Wash on Human Epidermal Penetration
Chapter 7. Fuller's Earth: Old and Faithful Skin Decontaminant Against Toxic Agents
Chapter 8. Comparison of Four Different Fullers Earth Formulations in Skin Decontamination
Chapter 9. The Mass Decontamination Paradigm: Response Relating to Gas Phase Exposures and Skin Decontamination
Chapter 10. Binding Affinity and Decontamination of Dermal Decontamination Gel (DDGel) to Model Chemical Warfare Agent (CWA) Simulants
Chapter 11. Dermostyx (IB1): High-efficacy and Safe Topical Skin Protectant Against Percutaneous Toxic Agents
Chapter 12. Understanding the Impact of Responder Management Strategies on Public Experiences and Behaviour During Mass Decontamination.

Summary: "Get practical guidance from renowned dermatologist Dr. Thomas Habif and his expert team of co-authors in this user-friendly, focused text. Written specifically for the non-specialist, this easy-to-follow reference offers precisely the diagnostic and treatment information you need to quickly identify the 250 skin disorders you're most likely to see. It's an ideal resource for any medical practitioner who'd rather treat than refer patients with skin disease, as well as an excellent review for board preparation"--Publisher's description.

Contents:
Topical therapy
Eczema
Urticaria
Acne, rosacea and related disorders
Psoriasis and other papulosquamous diseases
Bacterial infections
Sexually transmitted infections
Viral infections
Fungal infections
Exanthems and drug reactions
Hypersensitivity syndromes and vasculitis
Infestations and bites
Vesicular and bullous diseases
Connective tissue diseases
Light-related diseases and disorders of pigmentation
Benign skin tumors
Premalignant and malignant non-melanoma skin tumors
Nevi and malignant melanoma
Vascular tumors and malformations
Hair and nail diseases
Neonatal disease
Cutaneous manifestations of internal disease
Lasers in dermatology
Leishmaniasis
Leprosy (Hansen's diseases)

Summary: This book covers dermatological and related esthetic concerns specific to female patients. Since knowing whats normal is as important as knowing whats not, first chapters covers physiological differences in the skin of women and the changes during puberty, pregnancy, and menopause. Certain commonly encountered dermatoses are more frequent in females chronic telogen effluvium, rosacea, perioral dermatitis, pigmented contact (cosmetic) dermatitis, etc., which are explained in a more focused manner. Dermatoses exclusive to females involving the vulva is discussed at length. These include common papulosquamous conditions such as psoriasis, lichen planus, and lichen sclerosus as well as the uncommon but challenging plasma cell vulvitis. Breast dermatoses also are predominantly encountered in women and are described in detail in this book. Importantly, the safety of drugs and biologics in pregnancy and lactation have been covered too. One section is dedicated to the emotional and psychological burden of skin disease in women and certain disorders requiring psychiatric intervention such as obsessive-compulsive disorder (trichotillomania, trichotemnomania) and body dysmorphic disorder. Furthermore, commonly used cosmeceuticals and frequently performed esthetic procedures such as chemical peels, botulinum toxin, and soft tissue augmentation (fillers) are well explained. Skin diseases in females can cause a significant emotional and psychological impact that can sometimes be more serious than the physical impact. There is a paucity of comprehensive published literature in both journal and books and this book aims to fill that gap. This book is meant as a resource for dermatology residents and trainees, practitioners, and teachers. .

Contents:
Physiology of skin
Pregnancy dermatoses
Skin in pregnancy
Skin changes in Menopause
Acne in women
TSDF in females with skin of color
Rosacea
Hidradenitis suppurativa
Pigmentary disorders in women
Hair disorders
Metabolic syndrome: dermatologic aspects in females
Eczemas in women
Body dysmorphic disorder
DLQI in females : important disorders with low DLQIs
Treatment of cellulite
Breast augmentation - cutaneous aspects & complications
Vaginal rejuvenation
Treatment of the ageing face
The Sensitive Skin-Dos and Donts
A guide to botulinum toxin and fillers
Chemical peels and lasers-special consideration
Sexually transmitted diseases in women
Vulval disorders in women
Tropical diseases in women
Nail Disorders in women
Challenges faced by women dermatologists and training programs available to them.

Summary: As the number of surviving immune suppressed patients continues to rise, skin manifestations of patients have become increasingly important. AIDS patients, and renal, heart, liver, bone marrow, and lung transplant patients are now living longer and immunosuppressive drugs are being used more frequently. Diabetes is rising in the US and around the world, offering its own unique brand of immune suppressed skin diseases. The skin may be the earliest sign of these conditions and be the organ showing the most profound, earliest, and treatment limiting side effects. Skin Diseases in the Immunocompromised is the most comprehensive book on the topic available. It elucidates the signs of immune suppressed skin diseases to afford early diagnosis and management of this ever-increasing diverse group of illnesses. Organized for easy access, this book will be an essential resource for residents and fellows in dermatology and infectious diseases medical professionals.

Contents:
Skin Disorders in Immunocompromised Diabetes Patients
Skin Disorders of AIDS Patients
Skin Disorders in Patients with Primary Immunodeficiencies
Cancer Patients and Skin Disease
Skin Disease in Solid Organ Transplant Patients
Graft vs Host Disease and Skin Manifestations
Cutaneous Reactions to the Biologics
Cutaneous Reactions to Chemotherapy
Cutaneous Reactions to Corticosteroids
Cutaneous Reactions to Tyrosine Kinase Inhibitors
Cutaneous Manifestations of Aging and Immunodeficiency
UVA and UVB Therapy: Practical Applications and Implications for the Immunosuppressed Patient and Skin Disease
Skin Cancer in the Immunocompromised
Radiation Therapy for Non-melanoma Skin Cancer in Immunosuppressed Patients and Cutaneous Toxicity from This Therapy.

Summary: This richly illustrated book is a comprehensive guide to the dermatologic disorders that may be encountered in refugees and other migrants. It will equip readers to diagnose and treat a diverse range of skin diseases and conditions, including, but not limited to, infections caused by bacteria, viruses, fungi, and parasites, dermatologic manifestations of sexually transmitted diseases, dermatoses associated with malnutrition, pigmentary disorders, bullous diseases, connective tissue diseases, and benign and malignant cutaneous neoplasias. Attention is drawn to various neglected tropical skin diseases and to the characteristic signs of torture and genital mutilations. Helpful information is also provided on the significance of skin color and the relevance of ethnic and genetic factors. The clinical chapters are complemented by discussion of the circumstances that give rise to migration, such as poverty, war, and environmental conditions. This enables the reader to gain a more rounded understanding of patients circumstances that in turn will positively impact on patient care. This book will be of wide interest to dermatologists, whether experienced or in training, as well as to general physicians and researchers.

Contents:
Intro
Preface
Contents
Contributors
1: What Does It Mean to Be a Migrant, Asylum Seeker, or Refugee: Current Global Situation
1.1 The Human Rights Paradigm
1.2 Migration: Magnitude and Terminology
1.3 Why People Migrate: "Forced" and "Voluntary" Migrants
References
2: Medical, Social, and Civic Needs of Displaced Persons
References
3: Viral Dermatoses
3.1 Herpes Simplex Virus Infections
3.2 Human Papilloma Virus Infections
3.3 Pityriasis Rosea
References
4: Bacterial Dermatoses
4.1 Introduction
4.2 Clinical Features 4.2.1 Impetigo
4.2.2 Ecthyma
4.2.3 Folliculitis and Furuncles
4.2.4 Carbuncles
4.2.5 Abscess
4.2.6 Suppurative Paronychia
4.2.7 Erythrasma
4.2.8 Pitted Keratolysis
4.2.9 Erysipelas
4.2.10 Systemic Complications
4.3 Management
References
5: Non-Venereal Treponematoses
5.1 Introduction
5.2 Yaws
5.3 Bejel
5.4 Pinta
References
6: Fungal Infections
6.1 Superficial Mycoses
6.1.1 Dermatophytosis
6.1.1.1 Clinical Features and Treatment
6.1.2 Onychomycosis
6.1.3 Superficial Candidosis 6.1.3.1 Clinical Features and Treatment
6.1.3.2 Laboratory Diagnosis
6.1.4 Superficial Malassezia Infection
6.2 Deep Mycoses
6.2.1 Subcutaneous Mycoses
6.2.1.1 Clinical Features and Treatment
6.2.2 Systemic Mycoses
References
7: Protozoan Dermatoses
7.1 Introduction
7.2 Transmission
7.3 Clinical Features of CL
7.4 Diagnosis
7.5 Treatment
References
8: Helminthic Dermatoses
8.1 Nematodes
8.1.1 Cutaneous Larva Migrans (CLM)
8.1.1.1 Global Distribution
8.1.1.2 Diagnosis
8.1.1.3 Differential Diagnosis
8.1.1.4 Treatment 8.1.2 Lymphatic Filariasis
8.1.2.1 Global Distribution
8.1.2.2 Diagnosis
8.1.2.3 Differential Diagnosis
8.1.2.4 Treatment
8.1.3 Gnathostomiasis
8.1.3.1 Global Distribution
8.1.3.2 Diagnosis
8.1.3.3 Treatment
8.1.4 Loiasis
8.1.4.1 Global Distribution
8.1.4.2 Diagnosis
8.1.4.3 Treatment
8.1.5 Onchocerciasis
8.1.5.1 Global Distribution
8.1.5.2 Treatment
8.1.6 Strongyloidiasis
8.1.6.1 Global Distribution
8.1.6.2 Diagnosis
8.1.6.3 Treatment
8.2 Trematodes and Cestodes
8.2.1 Schistosomiasis 8.2.1.1 Global Distribution
8.2.1.2 Diagnosis
8.2.1.3 Treatment
8.2.2 Cysticercosis
8.2.2.1 Treatment
References
9: Dermatoses Caused by Arthropods
9.1 Bites and Stings
9.2 Insect Bites
9.3 Infestations
9.3.1 Scabies
9.3.2 Myiasis
9.3.3 Tungaiasis
9.3.4 Lice (Pediculosis and Pthiriasis)
References
10: Eczema and Dermatitis
10.1 Atopic Dermatitis
10.1.1 Pathogenesis
10.1.2 Epidemiological and Clinical Aspects
10.1.3 Differential Diagnosis
10.1.4 Histopathology
10.1.5 Treatment
10.1.5.1 Topical Therapies

Summary: This book focuses on neglected skin diseases and conditions in resource-poor countries through the lens of livelihoods. These diseases, when neglected, not only affect the skin, but also joint movement and physical appearance, severely influencing the lives and livelihoods of individuals and families in vulnerable communities. The book explores why neglected skin diseases thrive in resource-poor countries, and considers how this cycle might be broken by looking at the impact on livelihoods and access to healthcare in affected communities. The research is shaped by three guiding questions: Firstly, why have some measures been successful in one part of a population and not the other? Secondly, what is unique about vulnerable populations in various parts of the world? And thirdly, can the cycle of debilitating skin diseases and conditions in resource-poor countries be broken? In addressing these concerns, the book excavates past and present efforts in public health measures to combat these diseases, considers the impact of culture and livelihoods, and reviews some of the milestones in disease elimination and eradication. This book will be an indispensable source for health service planners, administrators and practitioners working with vulnerable populations, as well as students and researchers in public health. .

Contents:
Chapter 1:Skin Diseases; Need For Attention
Chapter 2:Types Of Skin Disease And Their Causes
Chapter 3:Impact of Skin Diseases in limited Resource Countries
Chapter 4:Prevention, Treatment And Control Of Skin Diseases
Chapter 5:Potential Public Health Measures To Tackle Skin Diseases
Chapter 6:Case Studies
Chapter 7:Reducing Burden Of Disease
Chapter 8:Milestones; Disease Elimination Success Stories.

Summary: Rheumatologic diseases are highly associated with clinical symptoms of the skin, nails, and mucosal membranes. This book provides the practicing rheumatologist with a rapid, easy to consult reference to help interpret the nature of these cutaneous lesions and then quickly decide upon the appropriate follow-up tests. Utilizing an abundance of informative photographs, it contains all of the essential information needed for early diagnosis and treatment. This comprehensive guide properly orients the practitioner within the challenging world of rheumatologic disorders of the skin and gives insight into when consultation with a dermatologist is advisable.

Contents:
Part I: Presentation of Skin Manifestation
Approach to Patients with Skin Manifestations
Chilblain Lupus Erythematosus
Erythema Nodosum
Livedo Reticularis
Malar Erythema
Purpura
Telangiectasias
Ulceration in Rheumatic Disease
Panniculitis
Diagnosing Puffy Fingers in the Rheumatic Patient
Part II: Methodology
Capillaroscopy
Use of Biopsy
Part III: Inflammatory Joint Disease
Skin Manifestations of Juvenile Idiopathic Arthritis
Psoriasis and Psoriatic Arthritis
Inflammatory Bowel Associated Spondyloarthropathy
Nodules in Rheumatoid Arthritis
Genital Involvement as a Result of Reactive Arthritis
Keratoderma Blennorrhagica as a Result of Reactive Arthritis
Parvovirus B19 Infection
Rheumatic Fever
Part IV: Connective Tissue Diseases
Skin Manifestations of Localized Scleroderma (LS)
Localized Scleroderma of the Face
Skin Manifestations of Raynaud's Phenomenon
Skin Manifestations of Systemic Sclerosis
Skin Manifestations of Neonatal Lupus Erythematosus
Skin Manifestations and Sjgren's Syndrome
Skin Manifestations of Systemic Lupus Erythematosus
Skin Manifestations in Dermatomyositis
Stiff Skin Syndrome
Nephrogenic Systemic Fibrosis
Graft-versus-Host Disease (GvHD): Cutaneous Manifestations
Scleromyxedema
Eosinophilic Fasciitis
Part V: Vasculitides
Kawasaki Disease
Dermatologic Manifestations of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)
Polyarteritis Nodosa
Skin Manifestations in Microscopic Polyangiitis
Henoch Schnlein Purpura
Skin Manifestations and Cryoglobulinemia
Skin Manifestations in Giant Cell Arteritis
Skin Manifestations of Behet's Disease
Familial Mediterranean Fever
Cryopyrin-Associated Periodic Syndromes
Part VI: Other Rheumatic Conditions
Sarcoidosis
Amyloidoses
Hypertrophic Osteoarthropathy.

Summary: In recent years, wound care has gained increasing recognition as a distinct medical specialty. An understanding of the complex mechanisms involved in wound healing facilitates efficient assessment and treatment of patients with wounds, and skin necrosis can be considered the starting point in the entire healing process. This book is the first to discuss skin necrosis as a symptom related to a broad range of pathologies. Richly illustrated, it primarily provides therapeutic strategies and treatment algorithms for different clinical contexts. All chapters were written by renowned specialists in their respected fields and include detailed sample cases and essential take-home messages. In light of the highly interdisciplinary nature of wound management, Skin Necrosis offers an invaluable resource for wound care practitioners and health care professionals across the fields of surgery, dermatology, internal medicine, and nursing.

Contents:
Anterior cranial fossa, nasal cavity, and paranasal sinuses / Sheldon D.S. Derkatch, Ian J. Witterick, Scott V. Bratman, Almudena Perez-Lara, Hugh D. Curtin, and Reza Forghani
Sellar, parasellar, and clival region / Amy W. Lin, Walter Kucharczyk, Ehab Y. Hanna, Brian O'Sullivan, and Eugene Yu
Cerebellopontine angle and jugular fossa / Laila S. Alshafai, Chris Heyn, John A. Rutka, Arjun Sahgal, Vincent Lin, Michael D. Cusimano, Sean Symons, Nabeel S. Alshafai, and Peter Som
Petroclival and lateral skull base / Rickin Shah, Gregory J. Basura, and Ashok Srinivasan
Open and endoscopic approaches to the sinonasal cavity and skull base / Nidal Muhanna, Christopher J. Chin, Allan D. Vescan, and John R. De Almeida
Post-treatment appearance following skull base therapy / Adam A. Dmytriw, John A. Rutka, Arjun Sahgal, Eugene Yu, and Peter Som
Neuroendovascular procedures for skull base neoplasia / Adam A. Dmytriw and Aditya Bharatha
Cross-sectional CT and MRI imaging atlas of the skull base / Almudena Perez-Lara, Eugene Yu, and Reza Forghani.

Contents:
Anterior Skull Base / David SY Sia, Clement Yong, James TPD Hallinan, Vincent Chong
Imaging of the paranasal sinuses and their surgical rleevance / Clement Yong, David SY Sia, James TPD Hallinan, Vincent Chong
The Sphenoid Bone / James TPD Hallinan, David SY Sia, Clement Yong, Vincent Chong
Imaging in endoscopic endonasal skull base surgery / Eric YS Ting, Fiona Ting, Ghim Song Chia, Vincent Chong
Temporal bone inflammatory and infectious diseases / Marc Lemming
Temporal bone tumors / Bert De Foer, Laura Wuyts, Anja Bernaerts, Joost van Dithers, Erwin Offeciers, Jan W. Casselman
Temporal bone trauma / Bert De Foer, Abdellatif, Anja Bernaerts, Joost van Dinther, Erwin Offeciers, Jan W. Casselman
Update on imaging of hearing loss / Lubdha M. Shah, Richard H. Wiggins III
Imaging of the facial nerve / Theresa Kouo, Robert E. Morales, Prashant Raghavan
Imging of the postoperative middle ear, mastoid, and internal auditory canal / Timothy L. Larson, Matthew L. Wong
Petrous apex / Ilona M. Schmalfuss
Imging of the cerebellopontine angle / Margaret N. Chapman, Osamu Sakai
Jugular Foramen / Chih Ching Choong, Eric T.Y. Ting, Vincent Chong
Imaging of the craniovertebral junction / Hon-Man Liu, Ya-Fang Chen
Skull base bone lesions I / Alexandra Borges
Skull Base Bone Lesions II / Alexandra Borges
Neurointerventional Radiology for Skull Base Lesions / Hon-Man Liu, Yen-Heng Lin.

Summary: This book is a comprehensive guide to skull base imaging. Skull base is often a "no mans land" that requires treatment using a team approach between neurosurgeons, head and neck surgeons, vascular interventionalists, radiotherapists, chemotherapists, and other professionals. Imaging of the skull base can be challenging because of its intricate anatomy and the broad breadth of presenting pathology. Although considerably complex, the anatomy is comparatively constant, while presenting pathologic entities may be encountered at myriad stages. Many of the pathologic processes that involve the skull base are rare, causing the average clinician to require help with their diagnosis and treatment. But, before any treatment can begin, these patients must come to imaging and receive the best test to establish the correct diagnosis and make important decisions regarding management and treatment. This book provides a guide to neuroradiologists performing that imaging and as a reference for related physicians and surgeons. The book is divided into nine sections: Pituitary Region, Cerebellopontine Angle, Anterior Cranial Fossa, Middle Cranial Fossa, Craniovertebral Junction, Posterior Cranial Fossa, Inflammatory, Sarcomas, and Anatomy. Within each section, either common findings in those skull areas or different types of sarcomas or inflammatory conditions and their imaging are detailed. The anatomy section gives examples of normal anatomy from which to compare findings against. All current imaging techniques are covered, including: CT, MRI, US, angiography, CT cisternography, nuclear medicine and plain film radiography. Each chapter additionally includes key points, classic clues, incidence, differential diagnosis, recommended treatment, and prognosis. Skull Base Imaging provides a clear and concise reference for all physicians who encounter patients with these complex and relatively rare maladies.

Contents:
Intro
Foreword
Acknowledgments
Contents
About the Authors
Quick Decoder for Acronyms and Abbreviations
Overview
Part I: Pituitary Region
1: Rathke's Cleft Cyst
Imaging
General Imaging Features
CT Features
MRI Features
Clinical Issues
Presentation
Epidemiology and Pathology
Treatment and Prognosis
Differential Diagnosis
A Closer Look
Selected References
2: Pituitary Adenoma
Imaging
General Imaging Features
CT Features
MRI Features
Clinical Issues
Presentation
Epidemiology and Pathology
Treatment and Prognosis Differential Diagnosis (DDx)
A Closer Look
Selected References
3: Craniopharyngioma
Imaging
General Imaging Features
Plain Films
CT Features
MRI Features [2, 3]
Clinical Issues
Presentation
Epidemiology and Pathology
Treatment and Prognosis
Differential Diagnosis (DDx)
A Closer Look
Selected References
4: Ectopic Neurohypophysis
Imaging
General Imaging Features
Plain Films
CT Features
MRI Features [2, 3]
Clinical Issues
Presentation
Epidemiology and Pathology
Treatment and Prognosis
Differential Diagnosis A Closer Look
Selected References
5: Hypothalamic Hamartoma
Imaging
General Imaging Features
CT Features
MRI Features
Clinical Issues
Presentation
Epidemiology and Pathology
Treatment and Prognosis
Differential Diagnosis
A Closer Look
Selected References
6: Neurohypophyseal Sarcoidosis
Imaging
General Imaging Features
CT Features
MRI Features
Clinical Issues
Presentation [1, 2]
Natural History
Epidemiology and Pathology
Treatment
Differential Diagnosis (DDx)
A Closer Look
Selected References 7: Intrasellar Arachnoid Cyst
Imaging
General Imaging Features
CT Features
MRI Features
Clinical Issues
Presentation
Natural History
Epidemiology and Pathology
Treatment
Differential Diagnosis (DDx)
A Closer Look
Selected References
8: Langerhans Cell Histiocytosis
Imaging
General Imaging Features
MRI Features
CT and Plain Film Features
Clinical Issues
Presentation
Natural History
Epidemiology and Pathology
Treatment and Prognosis
Differential Diagnosis
A Closer Look
Selected References
Part II: Cerebellopontine Angle 9: Epidermoid Cyst
Imaging
General Imaging Features
CT Features
MRI Features
T1 Signal
T2 Signal
DWI
CISS and FLAIR
Clinical Issues and Natural History
Presentation
Epidemiology and Pathology
Differential Diagnosis
Treatment and Prognosis
A Closer Look
Selected References
10: CPA Meningioma
Imaging
General Imaging Features
CT Features
MRI Features
Angiographic Features
Clinical Issues and Natural History
Presentation
Epidemiology and Pathology
Treatment
Prognosis
Differential Diagnosis of Solid CPA Masses

Summary: 'Skull Base Surgery' represents a genuinely multi-disciplinary collaborative approach to the standard procedures in skull base surgery. It emphasizes the basic operative steps of each approach and describes variations from the basic approach. Authors from the relevant specialties Neurosurgery, Otolaryngology, Maxillo-Facial Surgery and Plastic Surgery contribute to this new specialty of skull base surgery.

Contents:
Approaches to the Anterior Skull Base
Approaches to Central Skull Base
Approaches to Lateral Skull Base
Index.

Summary: Translational research connects science and clinical medicine from "the bench to the bedside." In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good "brain-gymnastics" for reconsidering the ideas on epilepsy.It provides contemporary knowledge about the neurophysiological and functional anatomical background of major epilepsiesTreats major epilepsies as system epilepsies of brain networksReveals the interrelationship of sleep, epilepsy and cognitive impairment showing how epileptic manifestations became facilitated in NREM sleep and interferes with sleep plastic functions

Contents:
1. Introductory considerations
2. Absence epilepsy as the system epilepsy of the non-rapid eye movement sleep-promoting system
3. Autosomal dominant nocturnal frontal lobe and nocturnal frontal lobe epilepsy as system epilepsies of the ascending cholinergic arousal system
4. Juvenile idiopathic myoclonic epilepsy (Janz Syndrome) as a system epilepsy affecting the corticothalamic system and the frontal motor and cognitive frontal subsystems
5. Medial temporal lobe epilepsy (MTLE): the epilepsy of the hippocampal declarative memory system
6. Idiopathic polyfocal hyperexcitability conditions (HIEC) of childhood and their transition to electrical status epilepticus in sleep
7. Epileptica encephalopathies
8. Summary.

Summary: Over the years there has been growing interest among the scientific community in investigating sleep and how it affects the memory and other brain functions. It is now well established that sleep helps in memory consolidation and induction of neural plasticity, and that short-term deprivation of either total sleep or rapid eye movement sleep alone can induce memory deficits very quickly. Quantitative and qualitative changes in sleep architecture after different training tasks further suggest that discrete memory types may require specific sleep stage/s for optimal memory consolidation, and studies indicate that sleep deprivation alters synaptic plasticity and membrane excitability in the hippocampal neurons and synaptic up-scaling in the cortical neurons. Further, sleep alteration during pregnancy may increase the risk of depression and adversely affect maternal-child relationships, parenting practices, family functioning, and children's development and general wellbeing. This book coherently discusses all these aspects, with a particular focus on the possible role of sleep in memory consolidation and synaptic plasticity. It also highlights the detrimental effects of sleep loss on mental health, the immune system and cognition. This book is a valuable reference resource for students and researchers working in the area of sleep, memory, or neuronal plasticity.

Contents:
The Memory Function of Sleep Across the Lifespan
Sleep Deprivation, Cognitive Functions and Countermeasures
Sleep Loss and Neuronal Stress
The Role of Sleep in Homeostatic Regulation of Ionic Balances and Its Implication in Cognitive Functions
Sleep and Brain Plasticity
The Role of Sleep in Emotional Processing
Sleep, Stress, and Traumatic Memory
The Distinctive Role of NREM and REM sleep in the Consolidation of Fear Memory
Sleep and Appetitive Conditioned Memory.

Contents:
Behavioral and electrophysiological correlates of sleep and sleep homeostasis
Genetic dissection of sleep homeostasis
Sleep deprivation and gene expression
Sleep and synaptic homeostasis
Sleep and synaptic plasticity in the developing and adult brain
Sleep and adult neurogenesis: implications for cognition and mood
Animal studies on the role of sleep in memory: from behavioral performance to molecular mechanisms
A bird's eye view of sleep-dependent memory consolidation
Neuroimaging studies of sleep and memory in humans
The role of sleep in human declarative memory consolidation
Sleep-dependent memory consolidation in healthy aging and mild cognitive impairment
Adenosine, caffeine, and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics
Optogenetic control of hypocretin (orexin) neurons and arousal circuits
Stress, arousal, and sleep
Sleep and emotional functions
Sleep and plasticity in schizophrenia
Chronically restricted or disrupted sleep as a casula factor in the development of depression
Sleep deprivation therapy for depression
Pharmacological treatment of sleep disorders and its relationship with neuroplasticity
Index.

Contents:
Part 1: Introduction
Ch. 1: War, Sleep and PTSD: War and War-related Trauma: An Overview
Ch. 2: Combat-Related Post Traumatic Stress Disorder: Prevalence and Risk Factors
Ch. 3: Sleep as a Mediator of mTBI and PTSD
Ch. 4: Gender Differences in Sleep and War Zone-Related Posttraumatic Stress Disorder
Part 2: Military Deployment and Sleep
Ch. 5: The Role Of Sleep In The Health And Resiliency Of Military Personnel
Ch. 6: Sleep Disturbance during Military Deployment
Ch. 7: Sleep and fatigue issues in military operations
Ch. 8: Suicidal Behavior in Posttraumatic Stress Disorder: Focus on Combat Exposure
Part 3: Neuroscience PTSD and Sleep
Ch. 9: PBRM1: Genetics of Posttraumatic Stress Disorder and Sleep Disturbance
Ch. 10: The Neurocircuitry of Fear and PTSD
Ch. 11: Brain Pathways of Traumatic Memory: Evidence from an Animal Model of PTSD
Ch. 12: Brain Structural Abnormalities in Posttraumatic Stress Disorder and Relations with Sleeping Problems
Ch. 13: PET Ligands Binding Specific Imaging Proteins in the Brain: The Application in PTSD
Part 4: Assessment of Sleep in relation to combat related PTSD
Ch. 14: Assessment of Posttraumatic Stress Disorder
Ch. 15: Sleep Disturbances and Sleep Assessment Methods in PTSD
Ch. 16: Sleep Changes in PTSD
Ch. 17: Actigraphy and PTSD
Ch. 18: The Extreme Nocturnal Manifestation of Trauma: Trauma Associated Sleep Disorder
Ch. 19: PTSD, arousal and disrupted (REM) sleep
Ch. 20: The Psychophysiology of PTSD Nightmares
Ch. 21: Sleep-Disordered Breathing and Posttraumatic Stress Disorder
Ch. 22: Heart Rate Variability, Sleep, and the early detection of Post-Traumatic Stress Disorder
Ch. 23: Sleep, Declarative Memory, and PTSD: Current Status and Future Directions
Part 5: Treatments of sleep disturbances in PTSD
Ch. 24: Psychotherapy Interventions for Comorbid Sleep Disorders and Posttraumatic Stress Disorder
Ch. 25: Cognitive Processing Therapy and Trauma-Related Sleep Disturbance
Ch. 26: Imagery Rehearsal Therapy for PTSD-related Nightmares
Ch. 27: Nightmare Deconstruction and Reprocessing for PTSD Nightmares
Ch. 28: Hypnotic Interventions for Sleep in PTSD
Ch. 29: Medication for sleep problems in posttraumatic stress disorder
Ch. 30: Pharmacology of Sleep and PTSD
Part 6: Specific Populations
Ch. 31: Posttraumatic Stress Disorder in Youth Exposed to War and Terror
Ch. 32: Predicting sleep quality and duration in adulthood from war-related exposure and posttraumatic stress in childhood
Ch. 33: Sleep disorders among Holocaust survivors
Ch.34 : Sleep Studies in Serbian Victims of Torture: analysis of traumatic dreams.

Contents:
Anatomy and physiology of normal sleep / L. Schneider
Anatomy and physiology of the circadian system / R.P. Najjar, J.M. Zeitzer
The functions of sleep and the effects of sleep deprivation / E.H. During, M. Kawai
Sleep and cognitive impairment / B.R. Peters, S.J. Sha, K. Yaffe
Sleep and movement disorders / L. Ashbrook, E.H. During
Sleep and stroke / G.J. Meskill, C. Guilleminault
Sleep and epilepsy / B. Razavi, R.S. Fisher
Central nervous system hypersomnias / J. Cheung, C.M. Ruoff, E. Mignot
Sleep and multiple sclerosis / D.J. Kimbrough, T.J. Braley
Sleep and neuromuscular disease / S. Sakamuri, J.W. Day
Sleep and headache / M. O'Hare, R.P. Cowan
Sleep and the autonomic nervous system / M.G. Miglis.

Contents:
The role of otolarynologist in the treatment of snoring and obstructive sleep apnea
Signs and symptoms of obstructive sleep apnea and upper airway resistance syndrome
Airway evaluation in obstructive sleep apnea
Clinical polysomnography
Home sleep testing
Drug-induced sleep endoscopy (DISE)
Obstructive sleep apnea : decision making and treatment planning
CPAP, APAP, and BiPAP
Analysis of CPAP failures
Oral appliances for OSA
Rationale and indications for surgical treatment
The impact of surgical treatment of OSA on cardiac risk factors
Perioperative and anesthesia management
Friedman tongue position and the staging of obstructive sleep apnea/hypopnea syndrome
Algorithm for surgery : paptopharyngoplasty first and foremost
Algorithm for multilevel treatment : the Riley, Powell, and Liu Stanford experience
Lingual tonsil hypertrophygrading system
The effect of oral positioning on hypopharyngeal airway dimensions
Algorithm for multilevel treatment : Friedman experience
Nasal obstruction and sleep-disordered breathing
Minimally invasive nasal valve repair
Plastic surgery techniques for correction of nasal obstruction
New techniques in nasal valve repair
Inferior turbinate reduction
Role of laser surgery in treatment of OSA
Cautery-assisted palatal stiffening operation and anterior palatoplasty
Injection snoreplasty
Sling snoreplasty
Elevoplasty
Palatal implants for primary snoring : short- and long-term results of a new, minimally invasive surgical technique
Classic uvulopalatopharyngoplasty
Uvulopalatopharyngoplasty : patient selection and effects on the airway
Zeta palatopharyngoplasty (ZPP)
The uvulopalatal flap
Modified uvulopalatopharyngoplasty with uvula preservation
Transpalatal advancement pharyngoplasty
Expansion sphincter pharyngoplasty
Barbed snore surgery (BSS)
Fundamentals of minimally invasive radiofrequency applications in ear, nose, and throat medicine
Radiofrequency tissue effects
Endoscopic coblator open tongue base resection for obstructive sleep apnea
Tongue base stabilization for obstructive sleep apnea and snoring
Endoscopic coblation lingual tonsillectomy
Electrical stimulation of the upper airway
Upper airway stimulation : implanted neurostimulation device treatment of obstructive sleep apnea
Multilevel pharyngeal surgery for obstructive sleep apnea
External submucosal glossectomy
Genioglossus advancement in sleep apnea surgery
Hyoid suspension as the only procedure
Management of the epiglottis
Transoral robotic surgery (TORS) for OSA
Multilevel surgery with or without genioglossal advancement
Maxillofacial surgical techniques for hypopharyngeal obstruction in obstructive sleep apnea
Modified maxillomandibular advancement technique
Distraction osteogenesis maxillary expansion (DOME) for adult obstructive sleep apnea patients
Tracheostomy for sleep apnea
Speech-ready, long-term tube-free tracheostomy for obstructive sleep apnea
The perioperative management of patients with obstructive sleep apnea
Multimodality management of nasopharyngeal stenosis after uvulopalatopharyngoplasty
Current techniques for the treatment of velopharyngeal insufficiency
Uvulopalatopharyngoplasty: analysis of failure
Salvage of failed palate procedures for sleep-disordered breathing
Revision uvulopalatopharyngoplasty (UPPP) for Z-palatoplasty (ZPP)
Management of sleep-related breathing disorders in children
Evaluation and management of persistent pediatric obstructive sleep apnea
Current techniques of adenoidectomy
Intracapsular microdebrider-assisted and coblation tonsillectomy
Laryngomalacia
Drug-induced sleep endoscopy in children
Prevention and correction of pediatric SDB/OSA and post-T&A relapse : a non-surgical orthodontic/dentofacial orthopedic approach
Innovations in surgical treatment of OSA.

Summary: 'Sleep Deprivation and Cognition,' Volume 247 in the Progress in Brain Research series, covers the effects of sleep deprivation, with this new release featuring sections on the Impact of sleep deprivation on long-term memory, Adolescent sleep restriction effects on cognition and mood, Self- regulation and social behavior during sleep deprivation, Experiential decision-making and the effects of sleep loss, Sleep deprivation and dynamic attentional control, a Pharmacogenetic approach to understanding sleep deprivation and cognition, Neuroimaging of functional connectivity in the sleep-deprived brain: what does it tell us?, and more. Key Features: Brings together scientists working in the area of sleep deprivation with scientists involved in research and theory in cognitive neuroscience; Fosters theory-driven research on sleep loss and cognition while also advancing a general understanding of cognitive neuroscience; Provides a foundation for the design of countermeasures to prevent human errors and accidents caused by sleep loss Readership: Everyone working in cognitive neuroscience and everyone studying the effects of sleep deprivation on cognition. -- Provided by publisher.

Summary: The cognitive and behavioral implications of sleep deprivation have been noted in the medical literature for many years. In addition, emerging research continues to demonstrate the contribution of sleep deprivation to some of the most common and costly health conditions today. Sleep Deprivation and Disease provides clinically relevant scientific information to help clinicians, public health professionals, and researchers recognize the ramifications of sleep deprivation across a broad spectrum of health topics. This timely reference covers sleep physiology, experimental approaches to sleep deprivation and measurement of its consequences, as well as health and operational consequences of sleep deprivation. Clinical challenges and areas of uncertainty are also presented in order to encourage future advancements in sleep medicine and help patients avoid the outcomes associated with the myriad causes of sleep deprivation.

Contents:
Part I Introduction
Sleep deprivation: practical and philosophical considerations
Part II Sleep Physiology, measurement, and experimental deprivation
The functional impact of sleep deprivation, sleep restriction, and sleep fragmentation
Methods for human sleep deprivation experiments
Imaging sleep and sleep deprivation
Part III Sleep and the brain
Sleep deprivation and neurological diseases
Sleep deprivation and psychiatric disorders
Sleep deprivation as a therapy for psychiatry
Part IV Sleep and medical topics
Sleep deprivation and human development
Sleep deprivation and pregnancy
Sleep deprivation and metabolism
Sleep deprivation and the cardiovascular system
Sleep deprivation and rheumatologic disease --Sleep deprivation and pain
Sleep loss in older adults: effects on waking performance and sleep-dependent memory consolidation with healthy aging and insomnia
Part V Performance, economics, and operational topics
Noise-induced sleep deprivation: toward sleeping soundly on noisy nights
Sleep deprivation and cognitive performance
Caffeine and naps a countermeasures for sleep loss
Fatigue in the workplace
Sleep deprivation and economic burden.

Summary: This book reviews and discusses the differential diagnoses for the common sleep related complaints encountered in sleep and primary care clinics. It meets the market need for a book that covers differential diagnosis in sleep medicine, and does so in a comprehensive manner. Organized into two sections by age demographic, adult and pediatric, clinical case studies are presented with medications, treatments, diagnoses, and patient medical histories. Specified sleep disorders examined include insomnia, nocturnal awakenings, restless sleeping, nightmares, and sleep apnea. Additionally, chapters include medical questionnaires created for patients in clinical scenarios to aid in learning. Unique and pedagogic, Sleep Disorders is written for physicians who practice in all primary care settings and as well as those sleep physicians in training.

Contents:
Part1. Adult sleep medicine. Sleepiness ; Insomnia ; Nocturnal Awakenings; Restless sleeper ; Breathing Pauses ; Sleep Paralysis ; Nightmares ; Inpatient Sleep Consultation ; Sleep Telemedicine
Part 2. Peds section. Snoring and restlessness during sleep in Children: Unique presentations, Diagnosis and Management ; Restless sleeper ; Obstructive sleep apnea and weight abnormalities in children.

Contents:
Part I: Introduction
Ontogeny of Sleep and Its Functions in Infancy, Childhood and Adolescence
The Discovery of Pediatric Sleep Medicine
Epidemiology of Sleep Disorders in Children and Adolescents
New Directions in the Link between Technology Use and Sleep in Young People
Sleep Laboratory Tests
Sleep Structure and Scoring from Infancy to Adolescence
Algorithm for Differential Diagnosis of Sleep Disorders in Children
Part II: Sleep Disorders
Sleep Disorders in Newborns and Infants
Pediatric Insomnia
Obstructive Sleep Apnea In Children: A Short Primer
Sleep Disorders in Children: Simple Sleep-Related Movement Disorders
Circadian Rhythm Disorders in Childhood
Disorders Associated with Increased Sleepiness
Parasomnias in Children
Sleep and Epilepsy
Sleep in Neurological and Neurodevelopmental Disorders
Sleep in Children with Psychiatric and Behavioral Problems
Childhood Sleep and Medical Disorders.

Summary: This book focuses on the sleep-related disorders in Parkinson's disease (PD), demonstrating that they are among the most common non-motor manifestations of PD and have a significant negative impact on quality of life. Sleep changes may also serve as markers to identify patients in the preclinical stage of PD. This book presents recent major breakthroughs related to sleep disorders in PD, such as REM sleep behavior disorder (RBD), insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. It also discusses the epidemiology, etiology, diagnosis, clinical implications, associated features, evaluation and management of these disorders and suggests some further research directions in these areas in order to develop neuroprotective therapies for PD. Focusing on Chinese PD patients, it addresses traditional Chinese Medicine, and compares the epidemiology and management of PD in China and Western countries to provide a frame of reference values for further studies. Further, it features numerous case reports to enable readers gain a better uderstanding of the subject matter. This comprehensive yet practical book is a valuable resource for scientists and clinicians.

Contents:
Intro
Preface
Acknowledgments
Contents
Part I: General Concepts
1: An Overview of Parkinson's Disease
2: An Overview of Roles of the Basal Ganglia in Sleep-Wake Regulation
2.1 Introduction
2.2 The Roles of the BG in the Sleep-Wake Cycle
2.3 The Role of the Dopaminergic and Adenosinergic System in the BG in the Sleep-Wake Cycle
2.4 A Model of NAc Involvement in Sleep-Wake Regulation
References
Part II: Classification of Sleep Disorders in Parkinson's Disease
3: REM Sleep Behavior Disorder (RBD)
3.1 Case Report
References
4: Insomnia 4.1 Introduction
4.2 Prevalence of Insomnia in Parkinson's Disease
4.3 Risk Factors of Insomnia in Parkinson's Disease
4.4 Etiologic Mechanisms of Insomnia in Parkinson's Disease
4.5 Clinical Manifestations of Insomnia in Parkinson's Disease
4.6 Diagnostic Criteria and Instruments of Insomnia in Parkinson's Disease
4.7 Treatment of Insomnia in Parkinson's Disease
4.8 Concluding Remarks
4.9 Case Report
4.9.1 Clinical Feature
4.9.2 Past History, Family History and Personal History
4.9.3 Physical Examination 4.9.4 Imageological Examination and Scale Assessment
4.9.5 Polysomnography (PSG)
4.9.6 Diagnosis
4.9.7 Treatment
4.9.7.1 Sleep Hygiene
4.9.7.2 Muscle Relaxation Therapy
4.9.7.3 Medication
References
5: Nocturia
5.1 Introduction
5.2 Causes for Nocturia in PD
5.2.1 Reduced Bladder Capacity
5.2.2 Nocturnal Polyuria
5.2.3 Circadian Rhythm Disturbances
5.2.4 Other Possible Mechanism for Nocturia in PD
5.3 Diagnosis and Evaluation of Nocturia in PD [14]
5.3.1 History Taking and Physical Examination
5.3.2 Investigation 5.3.2.1 Routine Test
5.3.2.2 Ultrasonography
5.3.2.3 Urodynamics
5.3.2.4 Other Investigations
5.4 Management and Treatment of Nocturia in PD
5.4.1 Pharmacological Interventions
5.4.1.1 Dopamine Agonists
5.4.1.2 Antimuscarinic Agents
5.4.1.3 Desmopressin
5.4.1.4 Melatonin
5.4.2 Intermittent Catheterization
5.4.3 Botulinum Toxin Injection
5.4.4 Surgical Treatment
5.4.5 Neuromodulation
5.4.6 Lifestyle Change
References
6: Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder
6.1 Introduction 6.2 The Association Between PD and RLS
6.3 Genetic Markers of RLS in PD
6.4 Pathophysiology of RLS in PD
6.5 Imaging of RLS in PD
6.6 Diagnosis of RLS in PD
6.7 Treatment of RLS in PD
References
7: Sleep-Related Breathing Disorders
7.1 Introduction
7.2 Causes of SBD in PD
7.3 Diagnosis [11]
7.3.1 History Taking and Physical Examination
7.3.2 Investigations
7.4 Treartment [14, 15]
7.4.1 Lifestyle Change
7.4.2 Medication
7.4.3 Continuous Positive Airway Pressure Therapy (CPAP)
References
8: Excessive Daytime Sleepiness

Summary: This book is designed to enable (pediatric) dentists to recognize the signs and symptoms of sleep disorders in their pediatric patients, it will help to understand the potential negative impact of a sleep disorder on the metabolic and cognitive neurodevelopment of a child and how to collaborate with others to implement appropriate management, including early (dentofacial) orthopedic intervention when necessary. A detailed examination of craniofacial signs and behavioral symptoms should alert the dentist to the potential presence of (a) sleep disorder(s) in children. The various treatment options other than positive airway pressure (PAP) therapy or adeno-tonsillectomy, which should be considered as potential life-saving short-term solutions, are discussed and shown. Treatment options that are discussed are dentofacial orthopedics (including orthotropics), orthodontics and orofacial myology; sample case outcomes are shown to demonstrate achievable results. Sleep Disorders in Pediatric Dentistry will serve as an excellent clinical guide that takes full account of recent developments in the field and explains the enormous potential that dentist can attribute to the patients overall (future) health. This book is also an excellent introduction for the general dentist to the medical world of (pediatric) sleep disorders. In this book a team of co-authors (2 medical doctors; 3 dental specialists; 3 general dentists and 3 dental hygienists) shared their knowledge that will educate the (pediatric) dentists about Sleep Disorders in Pediatric Dentistry.

Summary: This text highlights the importance of common medical comorbidities and illuminates the salient points for treatment, diagnosis, and management of these conditions as they relate particularly to these special populations. Written by experts in both sleep medicine and psychiatry, the text takes a cutting-edge, reader-friendly approach to topics that include sleep disturbances in pregnancy, sleep tele-medicine, sleep disturbances related to difficulties in schools, and substance-induced disturbances. Each chapter follows a consistent format, making it an excellent tool for the busy clinician who is not able to sift through scientific literature or didactic texts. Sleep Disorders in Selected Psychiatric Settings is an excellent resource for all clinicians who may work with special populations struggling with sleep and psychiatric comorbidities, including psychiatrists, sleep medicine physicians, primary care and family medicine physicians, pediatricians, obstetrics/gynecologists, psychologists and all others.

Contents:
My patient has trouble sleeping in the psych unit
Suicide and Insomnia
Cocaine Induced Insomnia/sleep problems
Cannabis Induced sleep problems
Insomnia and Generalized Anxiety Disorder
Withdrawal insomnia from benzodiazepines
Insomnia and Panic Disorder
People think Alcohol helps with sleep
Sleep apnea in Pregnancy
Stimulant Induced Insomnia in kids
Childhood Narcolepsy and Emotional problems of parents
RLS in Pregnancy
Insomnia in Pregnancy
Change in school time helped my teenager's sleep
Psychosocial issues with being a Sleepy Head
Extreme dreams make me depressed/Epic Dreaming
Sleep Disruption in ICU setting
Sexsomnia on Medications
I have claustrophobia on the CPAP mask. Please Help?.

Summary: In its 2nd Edition this book covers sleep disorders in women at all stages of life, exploring the impact of each reproductive and endocrine stage on both normal sleep and sleep disorders. Includes guidance for physicians on detecting and treating disorders.

Contents:
Intro
Series Editor Introduction
Preface to the Third Edition
Contents
Contributors
Part I: Overview
1: Introduction
References
2: Epidemiology of Sleep Disorders in Women
Introduction
Sleep Disordered Breathing
Primary Snoring
Upper Airway Resistance Syndrome
Obstructive Apnea / Hypopnea Syndrome
Central Sleep Apnea
Obesity Hypoventilation Syndrome
Insomnia
Restless Legs Syndrome (Willis- Ekbom Disease)
Hypersomnia
Parasomnia
REM Behavior Disorder
Conclusion
References
3: Life Cycle Impact on Sleep in Women Sleep Changes in Neonates and Infants
Sleep Changes in Childhood
Sleep Changes Around the Menstrual Cycle
Sex Hormones and Sleep
Sleep at Menarche
Sleep in Pregnancy
Sleep Duration and Sleep Quality in Pregnancy
Sleep in the Peri- and Post-menopausal Stages
Hormonal Changes and Sleep
Age-Related Sleep Changes
Sleep Changes Related to Mood Disorders
Bibliography
4: Normal Reproductive and Endocrine Life Stages: The Impact on Sleep Disorders
Insomnia
Menarche and Adolescence
Child-Bearing Years
Pregnancy
Post-Partum
Menopause and Beyond Restless Legs Syndrome and Periodic Limb Movement Disorder
Menarche and Adolescence
Child-Bearing Years
Menopause and Beyond
Obstructive Sleep Apnea (OSA)
Child-Bearing Years
Pregnancy
Menopause and Beyond
Sleepiness Disorders/Hypersomnias
Menarche and Adolescence
Child-Bearing Years
Menopause and Beyond
Circadian Disorders
Menopause and Beyond
Parasomnias
Menopause and Beyond
Conclusion
References
Part II: Sex and Gender Differences in Sleep
5: Sex Differences in Sleep
Introduction Sex Differences in Sleep Behavior and Sleep Architecture in Adults
When Do Sex Differences in Sleep Emerge? Sleep in Children and Adolescents
Sex Differences in Sleep under Challenge Conditions
The Role of Sex Steroids in Women
Conclusion
References
6: Sex Differences in Sleep Disorders
Introduction
Insomnia
Hypersomnias
Narcolepsy
Idiopathic Hypersomnia
Kleine-Levin Syndrome
Menstrual-Related Hypersomnia
Sleep-Disordered Breathing
Sleep-Related Movement Disorders
Restless Legs Syndrome
Periodic Limb Movement Disorder Other Sleep-Related Movement Disorders
Parasomnias
NREM-Related Parasomnias
Confusional Arousals and Sleep Terrors
Sleepwalking
Sleep-Related Eating Disorder
REM-Related Parasomnias
REM Sleep Behavior Disorder
Nightmare Disorder
Isolated Sleep Paralysis
Other Parasomnias
Exploding Head Syndrome
Sleep-Related Hallucinations
Sleep Enuresis
Circadian Rhythm Sleep Disorders
Conclusion
References
7: Sleep and Its Disorders Among Sexual and Gender Minority Populations
Introduction
Definitions
Minority Stress Theory and Sleep Health

Summary: Since publication of the first edition in 1994, the second edition in 1999, and the third edition in 2009, many new advances in sleep medicine have been made and warrant a fourth edition. This comprehensive text features 19 additional chapters and covers basic science, technical and laboratory aspects and clinical and therapeutic advances in sleep medicine for beginners and seasoned practitioners. With the discovery of new entities, many new techniques and therapies, and evolving basic science understanding of sleep, Sleep Disorders Medicine, Fourth Edition brings old and new knowledge about sleep medicine together succinctly in one place for a deeper understanding of the topic. Neurologists, internists, family physicians, pediatricians, psychiatrists, psychologists, otolaryngologists, dentists, neurosurgeons, neuroscientists, intensivists, anesthesiologists as well as those interested in advancing their knowledge in sleep and its disorders, will find this edition to be an invaluable resource to this bourgeoning field.

Contents:
Part I: Basic science of sleep. Introduction to the topic
Overview of normal sleep
Sleep deprivation and excessive daytime sleepiness
Effects of sleep deprivation and sleepiness on society and driving
Neurobiology of rem sleep, NREM sleep homeostasis, and gamma band oscillations
Basic circadian timing and sleep-wake regulation
Neurotransmitters, neurochemistry, and the clinical pharmacology of sleep
Neurobiology of NREM sleep and thermoregulation in sleep
Phylogeny of sleep
Sleep and anesthesia: different states with shared pathophysiological traits
Physiological changes of sleep
Sleep and immune regulation
Sleep and memory consolidation
Dreaming and sleep disorder
Study design and analysis in sleep medicine
Part II: Technical considerations. Instrumentation, electronics, and signal analysis
An overview of polysomnographic technique
Electroencephalography, electromyography, and electro-oculography: general principles and basic technology
Electrocardiography: principles and applications in sleep medicine
Evaluation and monitoring of respiratory function
Neuroimaging in normal and abnormal sleep
Multiple sleep latency test
Maintenance of wakefulness test
Scoring of normal sleep and arousals
Scoring of sleep-related breathing events
Part III: Clinical topics. Approach to the patient with sleep complaints
International classification of sleep disorders
Epidemiology: principles and application in sleep medicine
Genetics of sleep and sleep disorders
Nutrition and sleep
Sleep duration, morbidity, and mortality
Obstructive sleep apnea syndrome
Central sleep apnea, hypoventilation syndrome, and sleep in high altitude
Positive airway pressure in the treatment of sleep apnea-hypopnea
Preoperative, perioperative, and postoperative evaluation and management of sleep-disordered breathing
Oral appliances and surgical techniques for treatment of obstructive sleep apnea syndrome
Nature, evaluation, and treatment of insomnia
Narcolepsy and idiopathic hypersomnia
Motor control and dyscontrol in sleep
Evaluation and management of RLS and PLMD
Sleep, breathing, and neurologic disorders
Fatigue in clinical practice
Sleep, coma, vegetative and minimally conscious states
Sleep and epilepsy
Dreaming in neurological disorders
Sleep in psychiatric disorders
Sleep disturbances in general medical disorders
Evaluation and management of circadian rhythm sleep disorders
Rapid eye movement sleep behavior disorder
Parasomnias
Sleep disorders in the elderly
Evolution of sleep from birth to adolescence and sleep disorders in children
Sleep and sleep disorders in women
Sleep, violence, and forensic implications
General principle of treatment of sleep dysfunction and pharmacology of drugs used in sleep disorders
Sleep and alternative medicine: I
Approach to sleep disorders in the traditional school of Indian medicine: alternative medicine II
Sleep in extreme environment
Erratum to: sleep disorders medicine
Epilogue.

Summary: For decades heavily sedated ICU patients were assumed to be asleep. However, in the past 20 years, physiologic and epidemiologic studies have established sleep is frequently disrupted in the ICU. The inter-relationship between ICU sleep, delirium, and survivorship has come to the forefront of ICU practice. We now routinely aim for lighter sedation, delirium assessment has become standardized, and knowledge regarding the ICU factors leading to Post- Intensive Care Syndrome (PICS) has evolved. The importance of sleep in routine ICU management was codified for the first time in SCCMs 2018 PADIS guidelines. This state of the art book summarizes current knowledge regarding sleep during critical illness and recovery and how the risk factors, recognition, and outcomes associated with sleep in the ICU differ from those of healthy adults. Chapters address sleep quality in both the research environment and during routine care, the factors that disrupt sleep architecture and circadian biology in the ICU setting, medications that alter sleep architecture and those that can be used to improve it, the relationship between sleep and sedation and between sleep and delirium, and current strategies that can be used to improve sleep in the vulnerable ICU population. Written by experts in the field, Sleep in Critical Illness is a valuable resource for all members of the ICU interprofessional team including critical care physicians, nurses, physician assistants, pharmacists, and respiratory therapists as well as clinicians who consult in the ICU and post-ICU settings. .

Contents:
Characteristics of sleep in critically ill patients. Part I: Sleep fragmentation and sleep stage disruption
Characteristics of sleep in critically ill patients. Part II: Circadian rhythm disruption
Unique neurophysiologic findings in the critically ill: "Atypical sleep and pathologic wakefulness"
Normal sleep compared to altered consciousness during sedation.-Biologic effects of disrupted sleep
Risk factors for disrupted sleep in the ICU
Effects of common ICU medications on sleep
Sleep disruption and its relationship with delirium: Electroencephalographic perspectives
Sleep disruption and its relationship with delirium: Clinical perspectives
Mechanical ventilation and sleep
ICU sleep disruption and its relationship with ICU outcomes
Long-term outcomes--sleep in survivors of critical illness
Methods for routine ICU sleep assessment and monitoring
Best practices for improving sleep in the ICU. Part 1: Non-pharmacologic
Best practices for improving sleep in the ICU. Part II: Pharmacologic
Sleep considerations in critically ill children
Sleep in Critical Illness: Future Directions. .

Summary: This concise text provides a quick reference to clinically relevant material in both sleep medicine and neuromuscular medicine. Divided into ten chapters, the book begins by laying the foundation for understanding sleep issues in neuromuscular disorders and moves on to offering an overview of sleep disorders in various neuromuscular conditions. Chapters feature practical advice in managing sleep issues, including an overview of noninvasive ventilation. The final part of the book provides useful tables, charts, pictures and flow charts for quick reference in sleep medicine and neuromuscular medicine. Filling a critical gap in the literature, this guide helps anyone treating neuromuscular patients understand the basics of sleep and neuromuscular disorders and its management.

Contents:
Sleep stages and cardiorespiratory monitoring
Neuromuscular respiratory weakness and its management
Sleep issues in motor neuron disease
Sleep issues in myopathic and muscular dystrophies
Sleep issues in NMJ disorders
Sleep issues in peripheral neuropathies-sleep apnea
Sleep issues in peripheral neuropathies-movement disorders
Sleep issues in pediatric neuromuscular disorders Part-1
Sleep issues in pediatric neuromuscular disorders Part-2
Basics of non-invasive ventilation
Practical aspects of non-invasive ventilation
Use and role of non-invasive ventilation in neuromuscular disorders
Troubleshooting with non-invasive ventilation- Frequently asked questions and their answers.

Contents:
Preface
Acknowledgements
Introduction
I. Evolution of Sleep Medicine by Historical Periods
Sleep in Ancient Egypt
Sleep Medicine in the Arab Islamic Civilization
Sleep Medicine in Ancient and Traditional India
Sleep Medicine in Ancient and Traditional China
Sleep in the Biblical Period
Sleep in the New Testament
The Greco-Roman Period
The Aztec, Maya, and Inca Civilizations
II. Sleep Medicine from the Medieval Period to the 19th Century
Sleep Medicine in the Middle Ages and the Renaissance
Sleep in the 17th and 18th Centuries
III. The Early Evolution of Modern Sleep Medicine
The Evolution of Sleep Medicine in the 19th and the Early 20th Century
The History of Polysomnography: Tool of Scientific Discovery
IV. Sleep Medicine Societies, Professional Societies, and Journals
A History Behind the Development of Sleep Medicine and Sleep Societies
Development of Sleep Medicine in Europe
Evolution of Sleep Medicine in Japan
History of Japanese Clinical Sleep Medicine
Sleep Medicine around the World (Beyond North American and European Continents)
V. Sleep Disorders in Historic Diseases
Cholera
Encephalities Lethargica
African Sleeping Sickness
Sleep and HIV Disease
VI. Historical Milestones of Individual Sleep Disorders
Evolution of the Classification of Sleep Disorders
History of Epidemiological Research in Sleep Medicine
The Insomnias: Historical Evolution
VII. Neurological Sleep Disorders
Narcolepsy ? Cataplexy Syndrome and Symptomatic Hypersomnia
Idiopathic Hypersomnia
Kleine-Levin Syndrome
Movement Disorders in Sleep
History of Restless Legs Syndrome, Recently Named Willis-Ekbom Disease
Sleep and Stroke
Sleep in Neurodegenerative Diseases
Sleep, Cognitive Dysfunction, and Dementia
Fatal Familial Insomnia and Agrypnia Excitata: Insights into Human Prion Disease Genetics and the Anatomo-Physiology of Wake and Sleep Behaviours
Epilepsy and Sleep
Sleep Disorders after Traumatic Brain Injury: Milestones in Perspective
Headache Syndromes and Sleep
VIII. Psychiatric and Psychological Sleep Disorders
Depression
Schizophrenia and Psychosis
Bipolar Disorder
IX. Respiratory Diseases
A Short History of Obstructive Sleep Apnea Syndrome
Upper Airway Resistance Syndrome: A Short History
Restrictive and Obstructive Lung Diseases and Sleep Disorders
NREM Arousal Parasomnias
REM Sleep Behavior Disorder
Chronobiology and Sleep
X. Medical Disorders and Sleep
Cardiovascular Disease and Sleep Dysfunction
Nonrestorative Sleep, Musculoskeletal Pain, Fatigue in Rheumatic Disorders and Allied Syndromes: A Historical Perspective
Sleep and Pain: Milestones and Advances from Research
Endocrine-Metabolic Disorders and Sleep Medicine
The Gut and Sleep
Impotence and Erectile Problems in Sleep Medicine
Women?s Health and Sleep Disorders
XI. Miscellaneous Important Aspects
The Emergence of Pediatric Sleep Medicine
Sleep Disorders, Cognition, Accidents, and Performance
Sleep Deprivation: Societal Impact and Long Term Consequences
Sleep Models
XII. Evolution of Treatment and Investigative Approaches in Sleep Medicine
A History of Non-Pharmacological Treatments for Insomnia
The Pharmacological Treatment of Sleep Disorders
Psychological Treatment of Insomnia: The Evolution of Behavior Therapy and Cognitive Behavior Therapy
Modafinil: Development and Use of the Compound
Phylogeny in Sleep Medicine
Gamma-Hyroxybutyrate (Sodium Oxybate): From the Initial Synthesis to the Treatment of Narcolepsy Cataplexy and Beyond
Development and Impact of Brain Imaging Techniques.

Summary: This book serves to fill the gap in medical training that neglects the bidirectional relationship between sleep medicine and psychiatry. Written by expert psychiatrists who are also trained in sleep medicine, the text translates between these two fields by covering both the classification of sleep disorders as International Classification of Sleep - third edition (ICSD-3) as it relates to mental health, and also the classification of mental health comorbidities as defined by the Diagnostic and Statistical Manual of Mental Disorders - 5 as they relate to sleep disorders. Chapters also address the neurobiological components of sleep and psychiatric consideration, pharmacological considerations, behavioral therapeutic remedies, and unique challenges in special populations, such as pregnant women, children, and others. Sleep Medicine and Mental Health is an excellent resource for all physicians treating patients with sleep disorders who may also have psychiatric considerations, including psychiatrists, sleep specialists, neurologists, primary care physicians, and all others.

Contents:
Intro
Preface
Introduction
References
Contents
Contributors
Part I: Introduction
1: Introduction to Sleep and Sleep Disorders
Introduction
Functions of Sleep
Normal Sleep and Sleep Architecture
Non-Rapid Eye Movement Stages (NREM)
Rapid Eye Movement Stage (REM)
Process C and Process S
Sleep Changes Over Life Stages
Neurobiology and Neuroanatomy of Sleep
Sleep Disorder Classifications
Effects of Psychotropic Medications on Sleep
Interaction Between Sleep Disorders, Psychiatric Complications, and Medical Problems
Sleep Assessment Measures Conclusion
References
Part II: Insomnia
2: Insomnia
Introduction
Prevalence and Chronicity
Insomnia and Consequences
Models of Insomnia
The Stimulus Control Model
The Three Factor (3-P) Model
The Neurocognitive Model
Diagnosis of Insomnia
Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) [51]
International Classification of Sleep Disorders-Third Edition (ICSD-3) [52]
International Classification of Disorders-Tenth Edition (ICD-10-CM) [53]
Insomnia Subtypes
Adjustment Insomnia (Acute)
Idiopathic Insomnia (Childhood Onset) Paradoxical Insomnia (Sleep State Misperception)
Inadequate Sleep Hygiene
Behavioral Insomnia of Childhood
Psychophysiological Insomnia (Conditioned Insomnia)
Insomnia Due to Mental Disorder
Insomnia Due to Medical Condition
Insomnia Due to Drugs or Substances
Evaluation and Treatment
Conclusion
References
3: Cognitive-Behavioral Therapy for Insomnia (CBT-I)
Introduction
Cognitive-Behavioral Therapy for Insomnia (CBT-I): What Is It?
Sleep Pattern Assessment
Sleep Education
Stimulus Control Therapy
Sleep Restriction Therapy Managing High Arousal and Utilizing Cognitive Restructuring
Creating a Relaxing Environment for Sleep
Cognitive Restructuring
Efficacy of CBT-I
Modality: Does CBT-I Format Affect Improvements in Sleep?
Contraindications to CBT-I
Insomnia, Comorbid Health Conditions, and CBT-I
Physical Health Conditions
Mental Health Conditions
Hypnotic Medication Use and CBT-I
CBT-I by Age Group
Children
Adolescents
Older Adults
CBT-I Limitations
Summary
References
4: Yoga and Mindfulness-Based Cognitive-Behavioral Therapy for Insomnia (Y-MBCTi)
Introduction Approach to Assess Insomnia
Role of Yoga and Mindfulness Interventions in Insomnia
The Components of the Y-MBCTi Model
Goal of Y-MBCTi
Components of Y-MBCTi
Customizations in the Y-MBCTi
Achieving the Meditation Skills Before Implementing the CBT Interventions is the Key to Success in this Therapy
General Instructions on Meditation for Clients Using the Y-MBCTi Model
Instructions for Meditation
The Five-Step SPASM Method for Honing Meditation Skills
General Instructions on Sleep Hygiene for Clients Using the Y-MBCTi Model

Summary: Sleep is considered one of the vital signs and has become an important public health issue in our society. Thus, sleep impacts on overall health and, conversely, certain common medical conditions can impair sleep. Emerging evidence, in conjunction with clinical experience, demonstrates that physical therapy improves several sleep disorders and also optimized sleep contributes to boost rehabilitation. As health care professionals, physical therapists are singularly concerned with well-being and need to be competent to instruct their patients to rest and sleep. This book discusses evidences of physiotherapy and sleep medicine. It elucidates the neurophysiological background and mechanisms for physiotherapeutic resources and techniques, directing the future for promising research in the area. Divided in seven sections, the work initially addresses the basic concepts of sleep and physiotherapy and its relation to practice, including the importance of sleep medicine for health. The second section focuses on the basic conceptions of physical therapists' understanding and working in clinical practice and research with sleep.The next section reviews the most common sleep disturbances such as insomnia, restless legs syndrome, and respiratory sleep disturbances. Special populations, spotlighting childhood and adolescence, women physiologic reproductive stages, sleep and gender, and sleep and pain interactions are also examined. Last sections discuss the physical therapy resources to improve sleep and to treat sleep disturbances. This title is an essential resource not only for graduate students, residents, health professionals and physiotherapists working in prevention and rehabilitation, but also for researchers interested in screening, diagnostic and treatment innovations. It is addressed to neurologists, sleep medicine specialists and physical educators as well.

Contents:
Part I. Basic Concepts. - 1. Sleep: definition, concept, new area for physical therapy
2. Normal Sleep: Interindividual Differences and Sleep Variability
3. Brief history of Sleep Medicine and its importance for overall health
Part II. Sleep medicine for the physical therapist
4. Basic principles of physiotherapeutic sleep practice
5. Sleep physiology and neuroendocrinology for physiotherapists
Part III. Physiotherapeutic management of sleep disturbances
6. Insomnia: an overview
7. Insomnia: Physiotherapeutic approach
8. Restless Legs Syndrome (Willis-Ekbom Disease) and Periodic Limb Movements of Sleep: an overview
9. Restless Legs Syndrome (Willis-Ekbom Disease) and Periodic Limb Movements of Sleep: Physiotherapeutic approach
10. Circadian rhythm sleep disturbances: an overview
11. Physical therapy in circadian rhythm disorders: chrono-rehabilitation?
12. Sleep bruxism: an overview
13. Sleep bruxism: Physiotherapeutic approach
14. Obstructive sleep apnea: an overview
15. Obstructive sleep apnea: Physiotherapeutic approach
16. Central sleep apnea: an overview
17. Central sleep apnea: Physiotherapeutic approach
18. Upper airway resistance syndrome: an overview
19. Upper airway resistance syndrome: Physiotherapeutic approach
20. Narcolepsy: an overview
21. Excessive daytime sleepiness: an overview
22. Narcolepsy and Excessive daytime sleepiness: Physiotherapeutic approach
23. Parassomnias: an overview
Part IV. Sleep in specific conditions
24. Sleep-wake disturbances in childhood and adolescence
25. Sleep and aging
26. Sleep and gender differences
27. Sleep in neurologic diseases
28. Sleep and Chronic Pain Interlaced Influences: Guidance to physiotherapy practice
Part V. Physiotherapeutic resources/methods/techniques to improve sleep
29. Exercise and sleep
30. Hydrotherapeutic resources for sleep management
31. Optimizing behavior strategies for sleep
32. Sleep ergonomics
Part VI. Evidence from basic science and its contribution to physical therapy in sleep medicine
33. Basic research for sleep physiotherapy
34. Sleep and musculoskeletal system
Part VII. Sleep assessment for physical therapy clinical practice
35. Subjective assessment of sleep
36. Objective assessment of sleep
37. Actigraphy.

Summary: A new addition to the Neurology in Practice series, Sleep Medicine in Neurology is a practical guide for neurologists diagnosing and managing sleep disorders in their patients. As a part of the series, various feature boxes are highlighted throughout. ""Tips and Tricks"" give suggestions on how to improve outcomes through practical technique or patient questioning. In addition, ""Caution"" warning boxes supply helpful advice on how to avoid problems and 'Science Revisited' boxes offer quick reminders of the basic science principles necessary for understanding the presented concepts.

Contents:
Introduction to sleep medicine / Douglas B. Kirsch
The history and physical examination of the sleep patient / Sheila C. Tsai
Subjective and objective sleep testing / Martha E. Billings and Nathaniel F. Watson
Using medications to treat insomnia / Andreea Andrei
Approach to a patient with excessive daytime sleepiness / Rajdeep Singh and Aatif M. Husain
Approach to a patient with narcolepsy / Ravichand Madala and Rodney A. Radtke
Evaluation and medical management of sleep disordered breathing / Mihaela H. Bazalakova and Lawrence J. Epstein
Surgical management of sleep disordered breathing / Masayoshi Takashima, Jaime Gateno, Melinda Davis-Malessevich and Robert Busch
Medical comorbidities associated with obstructive sleep apnea / Emerson M. Wickwire and Scott G. Williams
Non-pharmacological treatments of insomnia and circadian rhythm disorder : special focus on neurology patients / Mary Rose
Parasomnias : diagnosis, evaluation, and treatment / Douglas B. Kirsch
Restless leg syndrome, periodic limb movements and other movement disorders in sleep / Raman Malhotra
Sleep and neurological disorders / Maryann C. Deak
Cognition, driving and sleep / Makoto Kawai
Pediatric sleep medicine / Shalini Paruthi.

Summary: This practical text provides knowledge of the basic neuroscience of sleep and sleep disorders as they interrelate with various neurologic conditions. Chapters in the first section cover neural networks involved in normal sleep processes, including dreams and memory. Also discussed are how these neural networks interact in various sleep stages and sleep disorders, such as sleep related movement disorders. The book's second section explores the pathophysiology of sleep disorders in the spectrum of neurologic conditions in both adults and children. This includes sleep changes in patients with dementia, seizures, headaches, and stroke, and other common neurologic disorders. Sleep Neurology fills an important gap in the sleep medicine literature by providing the underpinnings of sleep disorders and will be of great value to students, residents, and clinicians.

Contents:
1. Neurobiology of Wakefulness
2. Neurobiology of Sleep
3. Neurobiology of the Control of Sleep
4. The Neurological Consequences of Sleep Deprivation
5. Neurobiology of Dreams
6. Neurobiology of Memory and Sleep
7. Neurobiology of Insomina
8. Narcolepsy and Central Nervous System Hypersomnias
9. Neurobiology of Parasominas
10. Neurobiology of Sleep Related Movements
11. Sleep in Seziure Disorders
12. Sleep in Headaches
13. Sleep in Cerebral Palsy
14. Sleep and Cerebrovascular Disorder
15. Sleep in Amyotrophic Lateral Sclerosis
16. Sleep After Traumatic Brain Injury
17. Disorders of Sleep and Wakefulness in Parkinson's Disease and other Movement Disorders
18. Sleep in Elderly Adults and in Subjects with Dementia.

Contents:
The history of sleep medicine / Guilleminault, C.
Advanced concepts in the pathophysiology of obstructive sleep apnea / White, D.P.
The history of sleep surgery / Yaremchuk, K., Garcia-Rodriguez, L.
Advances in the diagnosis of obstructive sleep apnea : drug-induced sedated endoscopy / Ravesloot, M., Benoist, L., van Maanen, P., Kezirianl, E.J., de Vries, N.
Novel positional devices for the treatment of positional obstructive sleep apnea, and how this relates to sleep surgery / Ravesloot, M., Benoist, L., van Maanen, P., de Vries, N.
Updated concepts on treatment outcomes for obstructive sleep apnea / Certal, V., Capasso, R.
Updated Friedman staging system for obstructive sleep apnea / Friedman, M., Salapatas, A.M., Bonzelaar, L.B.
Advancements of CPAP therapy for obstructive sleep apnea / Chen, N.-H.
Advances in oral appliances for obstructive sleep apnea / Jacobowitz, O.
Updated nasal surgery for obstructive sleep apnea / Johnson, D.M., Soose, R.J.
Updated palate surgery for obstructive sleep apnea / Li, H.-Y.
Updated hypopharyngeal surgery for sleep apnea / Woodson, B.T.
Updated minimally invasive surgery for sleep-related breathing disorders / Kotecha, B.
Advances in box surgery for obstructive sleep apnea : genioglossus advancement, hyoid suspension, and maxillomandibular advancement / Go, Y.H., Winston, T., Abdullah, V.J., Kim, S.W.
Multilevel obstructive sleep apnea surgery / Li, H.-C., Weaver, E.M., Lin, H.-S., Friedman, M.
Innovative surgery for obstructive sleep apnea : nerve stimulator / Sommer, J.U., Hørmann, K.
Robotic obstructive sleep apnea surgery / Song, T.T., Hsu, P.P.
Pediatric obstructive sleep apnea : where do we stand? / Huang, Y.-S., Guilleminault, C.
Future perspectives in sleep medicine / Huon, L.-K.A., Guilleminault, C.
Future perspectives in sleep surgery / Friedman, M., Salapatas, A.M., Bonzelaar, L.B.

Summary: The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com.

Contents:
Part 1. Basic Principles
1. The Function(s) of Sleep
2. Neuroanatomical and Neurochemical Bases of Vigilance States
3. Omics Approaches in Sleep-Wake Regulation
4. The Role of Glia in Sleep Regulation and Function
5. Sleep- and Wake-Like States in Small 1 Networks In Vivo and In Vitro
Part 2. Optogenetics and Pharmacogenetics
6. Optogenetic Dissection of Sleep-Wake States In Vitro and In Vivo
7. Pharmacosynthetic Deconstruction of Sleep-wake Circuits in the Brain
8. Clinical and Experimental Human Sleep-Wake Pharmacogenetics
Part 3. Sleep-Wake Pathologies
9. Clinical Sleep-Wake Disorders I: Focus on Hypersomnias and Movement Disorders During Sleep
10. Clinical Sleep-Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders
Part 4. Current and New Targets, and Therapeutic Prospects
11. GABA Receptors and the Pharmacology of Sleep
12. Advances of Melatonin-Based Therapies in the Treatment of Disturbed Sleep and Mood
13. Dopamine and Wakefulness: Pharmacology, Genetics, and Circuitry
14. Ketamine-Induced Glutamatergic Mechanisms of Sleep and Wakefulness: Insights for Developing Novel Treatments for Disturbed Sleep and Mood
15. Adenosine and Sleep
Part 5. Outlook
16. Adenosine and Sleep
17. Functional Interactions Between Sleep and Circadian Rhythms in Learning and Learning Disabilities
18. Sleep Physiology, circadian rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics.

Summary: "Human Impact Assessment (HuIA) is a relatively new concept describing an integrated process that encompasses both Health Impact Assessment and Social Impact Assessment and is used to anticipate the effects of programs, projects and decisions on human health and welfare. Sleep occupies approximately one-third of our lives, but its human impact remains largely unrecognized. The prevalence of excessive sleepiness is recognized to be increasing in industrialized societies. Sleepiness and fatigue have high costs in terms of both lives lost and socioeconomic impact. Sleepiness and Human Impact Assessment provides a comprehensive exploration of many different facets of sleepiness in our 24-hour society from the new HuIA point of view. Among the covered issues are the physiology and pathophysiology of sleep, its relationship to daytime alertness, fatigue and drugs, the relevance of sleep-related fatigue in various occupational settings and public safety. This book will be of assistance to physicians, occupational health professionals, ergonomists, researchers and decision-makers as they strive to understand the full significance of sleepiness and to create a culture of accountability in everyday life without sleep-related risks."--Publisher's website.

Summary: This book offers a valuable contribution to the field of minimally invasive coronary intervention, presenting the latest developments in slender catheters, their development and the related research findings. With the growing interest in trans-radial interventions (TRIs) and distal radial approach, "Slender PCI" has been popular in Japan. Although "Slender PCI" started with using a small diameter catheter of a 5Fr Guiding Catheter, recently it becomes a generic term for all minimally invasive catheter Interventions. "Slender PCI" not only makes less painful but also reduces exposure to radiation and contrast agents. In addition, the book highlights the distal radial approach, 5Fr guiding catheter for treating complex lesion, 4Fr guiding catheters, 3Fr diagnosis catheters. The authors share their experiences and know-how throughout, providing abundant illustrations to enhance readers understanding.

Contents:
Intro
Preface
Acknowledgments
Contents
Chapter 1: Introduction
Chapter 2: What Is Slender PCI?
References
Chapter 3: Evidence for Slender Percutaneous Coronary Intervention
3.1 Introduction
3.2 Issues for TRI in the Early Years
3.3 Large Inner Lumen 6 Fr. Guiding Catheter
3.4 Miniaturization of the Outer Diameter of the Guiding Catheter
3.5 Slender Sheath Development
3.6 Slender Techniques
3.7 Evidence of TRI
3.8 Evidence of Small-Sized Guiding Catheter
3.9 Bleeding Complications
3.10 Future Perspectives for Slender PCI
References Chapter 4: Less Invasive Intervention: From a Forearm Radial to Distal Radial Approach
4.1 Introduction
4.1.1 Significance of Radial Artery Occlusion after Radial Access
4.1.2 History of Distal Radial Access
4.1.3 DRA Puncture Technique
4.1.4 Our Experience of DRA Access
4.1.5 Complications of DRA Access
4.1.6 Conclusion
References
Chapter 5: Distal Transradial Access for Arterial Angiography and Interventions: An Overview of Knowledge
5.1 Introduction
5.2 Rationale and Backgrounds
5.2.1 Applied Anatomy
5.2.2 Advantages for the Patient 5.2.3 Advantages for the Operator
5.3 Preparation and Technique
5.3.1 Patient Selection
5.3.2 Patient Preparation
5.3.3 Local Anesthesia
5.3.4 Ultrasound
5.3.5 Puncture Site
5.3.6 Puncture Direction
5.3.7 Puncture and Wire Insertion
5.3.8 Skin Incision
5.3.9 Sheath Selection
5.3.10 Medication
5.3.11 Wire Insertion
5.3.12 Catheter Selection
5.3.13 Hemostasis
5.4 How to Start a (l)dTRA Program
5.4.1 Learning Curve
5.4.2 Preparation
5.4.3 Role of a Proctor
5.4.4 General Recommendations
5.5 Potential Complications 5.5.1 Distal Radial Artery Occlusion (dRAO)
5.5.2 Digital Ischemia
5.5.3 Nerve Damage
5.5.4 Hematoma
5.5.5 Pseudoaneurysm (PSA)
5.5.6 Arteriovenous Fistula (AVF)
5.5.7 Avascular Necrosis Scaphoid (AVN)
5.5.8 Tendinitis
5.5.9 Hand Dysfunction
References
Chapter 6: Ultimate Less Radial Artery Occlusion Hemostasis Method on Slender PCI
6.1 Introduction
6.2 RAO Preventive Strategies History
6.3 Diagnosis and Treatment
6.4 Latest Progress in Reduction of Early RAO
6.5 Importance of Short and Soft Compression 6.6 Our Slender Approach and Postprocedural Care
6.7 Conclusion
References
Chapter 7: Distal Radial Approach for ST Elevation Myocardial Infarction
7.1 Introduction
7.2 Representative Case
7.3 Procedural Considerations
7.3.1 Patient Selection and Exclusion
7.3.2 Puncture
7.3.3 Hemostasis
7.4 Clinical Significance of Distal Transradial Access
7.4.1 Hemorrhagic Complication
7.4.2 Radial Artery Occlusion
7.4.3 Concerns Over Delay in Revascularization (Longer Door-to-Balloon Time)
7.5 Conclusion
References

Contents:
Intro; Preface; Acknowledgements; Contents;
Chapter 1: Introduction; 1.1 Historical Perspectives; 1.1.1 The Sliding Filament Model; 1.1.2 New Experimental Techniques; 1.1.3 Models of Contractility; 1.2 A Short Guide to Contractile Behaviour; 1.3 The Structure of Skeletal Muscle; 1.3.1 Muscle Ultrastructure; References;
Chapter 2: Of Sliding Filaments and Swinging Lever-Arms; 2.1 Contractile Empiricism: Hillś Equations; 2.2 How Myosin Heads Find Actin Sites; 2.2.1 Head-Site Matching for Vernier Models; 2.2.2 Lattice Models: Target Zones, Layer Lines and Azimuthal Matching 2.3 The First Sliding-Filament Model2.4 The Swinging-Lever-Arm Mechanism; 2.4.1 Mechanokinetics of the Working Stroke; 2.4.2 Theory of the Rapid Length-Step Response; References;
Chapter 3: Actin-Myosin Biochemistry and Structure; 3.1 How Myosin and Actin Hydrolyze ATP; 3.1.1 Myosin is an ATPase; 3.1.2 Actomyosin is a Better ATPase; 3.1.3 Steady-State ATP Hydrolysis by Actin-Myosin; 3.2 The Biochemical Contraction Cycle; 3.2.1 Actin Binding Versus Nucleotide Binding; 3.2.2 A Biochemical Cycle for Myosin-S1; 3.2.3 Evidence for Two A.M. ADP States; 3.2.4 Evidence for Two M. ATP States 3.3 Coordinating Lever-Arm Movements with Biochemical Events3.3.1 What Biochemical Event Triggers the Working Stroke?; 3.3.2 The Location of the Repriming Stroke; 3.3.3 An Amalgated Mechanochemical Cycle; 3.4 The Atomic Structure of Myosin Complexes; 3.4.1 Actin Binding; 3.4.2 Phosphate Release and the Working Stroke; 3.4.3 An ADP-Release Stroke; 3.4.4 ATP Binding and Actin Affinity; 3.4.5 The Repriming Stroke and Hydrolysis; 3.4.6 Hydrolysis on Actomyosin?; 3.4.7 The Pathway of the Stroke; References;
Chapter 4: Models for Fully-Activated Muscle; 4.1 Strain-Dependent Kinetics 4.1.1 Kramers' Method for Reaction Rates; 4.1.2 Actin Binding: Swing, Roll and Lock; 4.1.3 The Kinetics of the Working Stroke; 4.1.4 An ADP-Release Stroke; 4.2 The Evolution of Contraction Models; 4.2.1 A Two-State Stroking Model; 4.2.2 The Search for a Simple Vernier Model; 4.2.3 Lattice Models; 4.3 Computational Methods; 4.3.1 Probabilistic Methods; 4.3.2 Monte-Carlo Simulation; 4.4 The Effects of Filament Elasticity; 4.4.1 The Equivalent Lumped Filament Compliance; 4.4.2 Experimental Consequences; 4.5 Target Zones, Dimeric Myosins and Buckling Rods 4.5.1 Calculations with Target Zones and Dimeric Myosins4.5.2 An Updated 5-State Vernier Model; 4.5.3 Buckling Rods; 4.6 Adding Phosphate, ADP or ATP; 4.6.1 Added Phosphate; 4.6.2 Changing ADP or ATP; 4.7 The Effects of Temperature; References;
Chapter 5: Transients, Stability and Oscillations; 5.1 Chemical Jumps and Temperature Jumps; 5.1.1 The Activation Jump; 5.1.2 Pi Jumps; 5.1.3 ATP Jumps; 5.1.4 Temperature Jumps; 5.2 Length Steps; 5.2.1 The Length-Step Response; 5.2.2 Repeated Length Steps; 5.3 Sinusoidal Length Changes; 5.4 Force Steps; 5.4.1 Isotonic Oscillations

Summary: In this book the author describes in detail the history, construction, and examination potential of the slit lamp. In particular, however, he presents a new approach videography that allows the ophthalmologist to document all (!) eye diseases with the slit lamp and a video camera in a practicable, rapid, and affordable manner. The necessary methods, techniques, and equipment, including converging, diverging, and contact lenses, are clearly explained in the text and four didactic videos. The 20 most important videographic settings are described, and recipes for their use are presented, along with diagnostic tips. The accompanying collection of clinical images represents the world's first ever general atlas of ophthalmology from the perspective of the slit lamp. The author has already demonstrated proof of the value of ophthalmological videography in his own practice. It is his hope that this introductory book, with its many images never previously produced with a slit lamp, will stimulate others to exploit the approach's potential.

Contents:
Basics: Appliance Construction. Biomicroscopy: Types of Illumination
Biomicroscopy without Additional Lenses
Biomicroscopy with Additional Lenses
Accessory Equipment for Slit Lamps. Videography with the Slit Lamp: Videography - the Basics
Special Videography Applications
Specific Videographic Settings for Specific Ocular Diseases. History of the Slit Lamp: History of Slit Lamp Construction.

Summary: "A radical new understanding of how medicine is best practiced, from the award-winning author of God's Hotel. Over the years that Victoria Sweet has been a physician, "healthcare" has replaced medicine, "providers" look at their laptops more than at their patients, and costs keep soaring, all in the ruthless pursuit of efficiency. Yet the remedy that economists and policy makers continue to miss is also miraculously simple. Good medicine takes more than amazing technology; it takes time--time to respond to bodies as well as data, time to arrive at the right diagnosis and the right treatment. Sweet knows this because she has learned and lived it over the course of her career. Here she relates unforgettable stories of the teachers, doctors, nurses, and patients through whom she discovered the practice of Slow Medicine, in which she has been a pioneer. Medicine, she makes us see, is a craft and an art as well as a science. It is relational, personal, even spiritual. To do it well requires a hard-won wisdom that no algorithm can replace--that brings together "fast" and "slow" in a truly effective, efficient, sustainable, and humane way of healing"-- Provided by publisher. "The award-winning author of God's Hotel offers a radical reimagining of how we practice medicine"-- Provided by publisher.

Contents:
Medicine without a soul
On the cusp of Aquarius
Dr. Gurushantih and my new white coat
The man with a hole in his head
Dr. Greg's 30 percent solution
A successful petition to the saint of impossible causes
The mantle of Hippocrates
Three prophets, no whale
Visiting day at the henhouse
A slow medicine clinic before its time
Passing the point of no return
Intermission: in which fast medicine and slow medicine come together
Turnaround
A craft, a science, and an art
Upstairs, downstairs
A short pause to recapitulate, or The crack in the cosmic egg
The force that through the green fuse drives the flower
Nothing is better than life
A slow medicine manifesto.

Summary: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

Contents:
Role of small animal imaging. Noninvasive imaging for supporting basic research / Pat Zanzonico
Non-invasive imaging in the pharmaceutical industry / Sally-Ann Ricketts, Paul D. Hockings, John C. Waterton
How to set up a small animal imaging unit / David Stout
Noninvasive small rodent imaging: significance for the 3R principles / Nicolau Beckmann, Peter Maier
Study planning and animal preparation. Institutional preconditions for small animal imaging / René H. Tolba
Statistical considerations for animal imaging studies / Hannes-Friedrich Ulbrich
Animal anesthesia and monitoring / Marc Hein, Anna B. Roehl, René H. Tolba
Drug administration / Klaus Nebendahl, Peter Hauff
Imaging modalities and probes. How to choose the right imaging modality / Fabian Kiessling, Bernd J. Pichler, Peter Hauff
X-ray and X-ray-CT / Willi A. Kalender, Paul Deak, Klaus Engelke, Marek Karolczak
Ct contrast agents / Hubertus Pietsch
Small animal magnetic resonance imaging: basic principles, instrumentation and practical issue / Peter Jakob
Mr contrast agents / Eliana Gianolio, Alessandra Viale, Daniela Delli Castelli, Silvio Aime
Mr spectroscopy / Markus Becker
Ultrasound / Stuart Foster, Catherine Theodoropoulos
Ultrasound contrast agents / Michel Schneider
Imaging modalities and probes. PET and SPECT / Sibylle I. Ziegler
Radiotracer I: standard tracer / Walter Mier, Uwe Haberkorn
Radiotracer II: peptide-based radiopharmaceuticals / Roland Haubner, Clemens Decristoforo
Optical imaging / Ralf B. Schulz, Vasilis Ntziachristos
Optical probes / Kai Licha
Multi-modal imaging and image fusion / Vesna Sossi
Ex vivo validation methods. Ex vivo and in vitro cross calibration methods / Albertine Dubois, Julien Dauguet, Thierry Delzescaux
In vitro methods for in vivo quantitation of PET and SPECT imaging probes: autoradiography and gamma counting / David Stout
Data postprocessing. Qualitative and quantitative data analysis / Felix Gremse, Volkmar Schulz
Guidelines for nuclear image analysis / Martin S. Judenhofer, Stefan Wiehr, Damaris Kukuk, Kristina Fischer, Bernd J. Pichler
Kinetic modelling / J̲örg van den Hoff
Data documentation systems / S̲nke H. Bartling, Wolfhard Semmler
Special applications. Imaging in developmental biology / Katrien Vandoorne, Stav Sapoznik, Tal Raz, Inbal Biton, Michal Neeman
Imaging in gynecology research / Matthias W. Laschke, Michael D. Menger
Imaging in cardiovascular research / Michael Schäfers, Klaus Tiemann, Michael Kuhlmann, Lars Stegger, Klaus Schäfers, Sven Hermann
Imaging in neurology research I: neurooncology / Yannic Waerzeggers, Parisa Monfared, Alexandra Winkeler, Thomas Viel, Andreas H. Jacobs
Imaging in neurology research II: PET imaging of cns disorders / Gjermund Henriksen, Alexander Drzezga
Special applications / Imaging in Neurology Research III: Focus on Neurotransmitter Imaging / Wynne K. Schiffer
Imaging in oncology research / Wolfgang A. Weber, Fabian Kiessling
Imaging in immunology research / Jason T. Lee, Evan D. Nair-Gill, Brian A. Rabinovich, Caius G. Radu, Owen N. Witte.

Contents:
Part one: Clinical signs approach to differential diagnosis
Part two: Systemic approach to differential diagnosis
Part three: Laboratory values and interpretation of results.

Contents:
Cardiopulmonary function / Orton
Cardiopulmonary monitoring and supportive care / Orton
Instrumentation / Orton
Thoracotomy / Orton
Sternotomy / Orton
Minimally-invasive thoracic surgery / Monnet, Orton
Thoracostomy and pleural drainage / Monnet
Thoracic wall / Monnet
Pleural effusions / Monnet
Pneumothorax / Monnet
Thymoma and mediastinal masses / Monnet
Esophagus / Orton
Vascular ring anomalies / Monnet
Trachea / Monnet
Lung / Monnet
Diaphragm / Orton
Pericardium / Monnet, Orton
Strategies for cardiac surgery / Orton
Patent ductus arteriosus / Orton
Pulmonary and aortic valves / Orton
Tricuspid and mitral valves / Orton
Congenital septal defects / Orton
Cor triatriatum and double-chambered right ventricle / Orton
Cardiac neoplasia / Orton
Epicardial pacemaker implantation / Monnet.

Summary: Like many fields of science, the future of medicine is frequently predicted by the science fiction writers of today, very much as many of today's medical advances were presaged by science fiction stories of the past. In this book, physician and science fiction author Brad Aiken conveys his own speculations about our medical future through nine highly entertaining and thought-provoking short stories. Touching upon a great variety of themes, including but not limited to telemedicine and remote surgery, vaccination strategies against unknown deathly pathogens, nanomedicine to cure diseases and retard ageing, bionics, cloning and euthanasia, we get a glimpse of what might be awaiting humanity. Yet, in these stories it is always the protagonists, humans after all, who remain at the center stage, not the new technologies. This provides the fictional material with a unique blend of science fiction and social fantasy. It also warns us to be wary of the pitfalls of too much reliance on dehumanizing technology and to make sure it remains our helper, not our master. Last but not least, an extensive scientific essay investigates the interplay between science fiction and both past and current advances in medical sciences and technology, making the link to the fictional material in the book as well as to the relevant scientific literature.

Contents:
Part I Short Stories
Locked In
Questioning the Tree
Freudian Slipstream
Done That, Never Been There
Hiding from Nobel
The Last Clone
If He Only Had a Brain
Once, On a Blue Moon
A Time to Every Purpose
Part II The Science behind the Fiction: The Invasion of Modern Medicine by Science Fiction.

Summary: This book provides comprehensive coverage of small fiber neuropathy (SFN), from diagnosis to therapy. It focuses on nerve degeneration and neuropathic pain, and their underlying pathology, physiology, psychophysics, genetics and imaging. In particular, this book describes and discusses the major advances in diagnostic techniques for assessing SFN. These include skin biopsy, evoked potentials, quantitative sensory testing and functional studies, as biomarkers of SFN. SFN is a common peripheral nerve disorder, but was often overlooked due to a lack of objective and specific diagnostic tests for the assessment of small nerve fibers. These fibers mediate thermal sensation, pain detection (nociception), and autonomic regulation. Major symptoms of SFN include neuropathic pain, impaired sensation and autonomic dysfunction. Neuropathic pain poses a diagnostic challenge to clinicians, an essential step for selecting appropriate treatment to relieve suffering. SFN frequently develops in systemic diseases such as diabetes mellitus, following chemotherapy, infections etc., or presents as a major feature of various genetic neuropathies (e.g. channelopathy and familial amyloidosis). In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity. This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN. It would be immensely useful for clinicians, neurologists, neuroscientists, diabetologists, and pain specialists. Dr. Sung-Tsang Hsieh is a professor at Department of Neurology and Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. He is also the associate dean of College of Medicine, National Taiwan University, Taiwan. Dr. Praveen Anand is a professor at Department of Clinical Neurology and head of Centre for Clinical Translation, Hammersmith Hospital, UK. Dr. Christopher Gibbons is an associate professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, USA. Dr. Claudia Sommer is a professor of Neurology at the Department of Neurology, Würzburg University Hospital, Germany.

Contents:
Overview of small fiber neuropathy and clinical aspects of small fiber neuropathy
Pathology of small fiber neuropathy: skin biopsy for nociceptive nerve
Neurophysiology: evoked potential
Psychophysics
Autonomic examinations and nerve pathology
Diabetic neuropathy, metabolic syndrome
Genetic small fiber neuropathy
Amyloid neuropathy
Small fiber involvment in conventional large fiber neuropathy
Vasculitis and autoimmune disorders, infectious neuropathy
Pain syndromes
Visceral pain and hypersensitivity disorders
Small fiber pathology in neurodegenerative disorders
Neuropathic pain in small fiber neuropathy
Therapy for small fiber neuropathy.

Summary: This book covers all aspects of small intestinal disease with the aim of providing an up-to-date reference of the highest quality that will assist in everyday clinical practice. After introductory chapters on anatomy, pathophysiology, epidemiology, and signs and symptoms, the roles of different imaging modalities in the diagnosis of small intestinal disease are clearly explained, focusing particularly on capsule endoscopy, device-assisted enteroscopy, CT and MR enterography, and nuclear medicine techniques. A series of chapters then address each of the diseases and conditions that may be encountered. The coverage is wide ranging, including, for example, obscure gastrointestinal bleeding, Crohns disease and other inflammatory conditions, celiac disease, Behcets disease, Meckels diverticulum, intestinal tuberculosis, and various malignancies. Numerous informative clinical cases are presented to identify characteristic imaging findings and assist in treatment decision making. Small intestinal disease continues to represent a significant challenge. The scope and detail of this book will make it an invaluable asset for gastroenterologists and other clinicians.

Contents:
1. Anatomy and physiology of small intestine
2. Epidemiology of small intestinal disease
3. Symptoms and signs of small intestinal disease
4. Diagnostic modalities for small intestinal disease
5. Capsule endoscopy
6. Device assisted small bowel endoscopy
7. Radiology (CT/MR enteroscopy)
8. Nuclear medicine and others
9. Clinical manifestations of small intestinal disease
10. Obscure GI bleeding
11. Vascular lesions
12. Crohns disease
13. Other inflammatory lesions
14. NSAID enteropathy
15. Intestinal tuberculosis
16. Behcet disease
17. Meckels diverticulum
18. Cryptogenic Multifocal Ulcerous Stenosing Enteritis
19. Celiac disease
20. Peutz-Jeghers syndrome
21. Adenocarcinoma
22. Lymphoma
23. GIST
24. Primary lymphangiectasia.

Contents:
Imatinib Mesylate
Dasatinib
Nilotinib
Bosutinib: a potent second-generation tyrosine kinase inhibitor
Ponatinib: a third-generation inhibitor for the treatment of CML
Ruxolitinib
Ibrutinib
Pomalidomide
Enasidenib
Midostaurin: a multiple kinases inhibitor in acute myeloid leukemia and systemic mastocytosis
Venetoclax: targeting BCL2 in hematological cancers
Idelalisib
Carfilzomib
Acalabrutinib, a second-generation Bruton's tyrosine kinase inhibitor.

Summary: Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Contents:
Erlotinib
Lapatinib
Regorafenib
Crizotinib
Cabozantinib: multi-kinase inhibitor of MET, AXL, RET, and VEGFR2
Vemurafenib
Trametinib (GSK1120212)-- Everolimus
Vismodegib
Larotrectinib (LOXO-101)
Palbociclib, the first of a new class of cell cycle inhibitors
Cobimetinib (GDC-0973, XL518)
Lenvatinib: a tyrosine kinase inhibitor of VEGFR 1-3, FGFR 1-4, PDGFRα, KIT and RET
Afatinib
Olaparib
Gefitinib
Alectinib
Osimertinib .

Contents:
Small non-coding RNAs : a quick look in the rearview mirror / Guillaume Clerget, Yoann Abel, and Mathieu Rederstorff
Alcoholic precipitation of small non-coding RNAs / Guillaume Clerget, Valérie Bourguignon-Igel, and Mathieu Rederstorff
Quantification and quality control of a small non-coding RNA preparation / Virginie Marchand and Christiane Branlant
Impact of RNA isolation protocols on RNA detection by Northern blotting / Katrin Damm [and seven others]
Improved Northern blot detection of small RNAs using EDC crosslinking and DNA/LNA probes / Katrin Damm [and seven others]
Direct cloning of double-stranded RNAs / Manli Shen [and three others]
Detection and labeling of small non-coding RNAs by splinted ligation / Gabrielle Bourgeois [and three others]
Fluorescence in situ hybridization of small non-coding RNAs / Valentin Vautrot [and three others]
RT-qPCR-based quantification of small non-coding RNAs / Fjoralba Zeka, Pieter Mestdagh, and Jo Vandesompele
Stem-loop RT-PCR based quantification of small non-coding RNAs / Véronique Salone and Mathieu Rederstorff
miR-RACE : an effective approach to accurately determine the sequence of computationally identified miRNAs / Chen Wang and Jinggui Fang
Probing small non-coding RNAs structures / Jean-Vincent Philippe [and three others]
cDNA library generation for the analysis of small RNAs by high-throughput sequencing / Jennifer Gebetsberger, Roger Fricker, and Norbert Polacek
CLIP-Seq to discover transcriptome-wide imprinting of RNA binding proteins in living cells / Jérôme Saulière and Hervé Le Hir
Microarray analysis of small non-coding RNAs / Michael Karbiener and Marcel Scheideler
RML-RACE, PPM-RACE, and qRT-PCR : an integrated strategy to accurately validate miRNA target genes / Chen Wang and Jinggui Fang
Dual luciferase gene reporter assays to study miRNA function / Thomas Clément, Véronique Salone, and Mathieu Rederstorff
Gene expression knockdown by transfection of siRNAs into mammalian cells / Yoann Abel and Mathieu Rederstorff
Efficient and selective knockdown of small non-coding RNAs / Xue-Hai Liang, Wen Shen, and Stanley T. Crooke
Cell-SELEX : in vitro selection of synthetic small specific ligands / Helena Dickinson [and three others]
Small non-coding RNAs and aptamers in diagnostics and therapeutics / Marissa Leonard, Yijuan Zhang, and Xiaoting Zhang.

Summary: The upcoming trends in healthcare are intended towards improving the overall quality of life. In the past,management of health issues were limited to clinics and hospitals and managing patients data and analyzing it. This procedure was difficult and time consuming. A great effort was also needed in diagnosing the cause and type of disease, but this all has changed now. As advancement in research and technologies, a positive impact on healthcare is seen. This book assesses the need and era of smart healthcare and delivers content relevant to current age and time. It describes the trend, usage and practicality of IWMDs i.e. Wearable Medical Device or Sensors (WMSs) and Implantable Medical Devices (IMDs) and how they enhance the awareness of daily healthcare.It establishes a relation and conjunction of daily healthcare monitoring with clinical healthcare. A healthcare system is called smart when there is an ability to make decisions, which comes from data analytics. Smart healthcare systems possess capability of data analytics and IoT based services which can be implemented on smart phones using cloud technology. This book discusses various research trends and technologies related to innovations and advancements for smart healthcare systems. It also elaborates challenges, scope upcoming techniques, devices and future directions for smart healthcare systems.The proposed book would in particular benefit researchers interested in interdisciplinary sciences, It would also be of value to faculty, research communities, and researchers from diverse disciplines who aspire to create new and innovative research initiatives.

Contents:
Smart Health-An Introduction
Technologies for Smart Health
Telehealth
Algorithms and Software for Smart Health
Scalable Smart Health Systems
Devices, Systems and Infrastructure for Smart Health
Cyber Physical System for Healthcare
Big Data Analytics and Cognitive Computing for Smart Health System
Values and Risks of Smart Health
Challenges/ Opportunities and Future Trends in Smart Health.

Summary: "Smart Nanoparticles for Biomedicine explores smart nanoparticles that change their structural or functional properties in response to specific external stimuli (electric or magnetic fields, electromagnetic radiation, ultrasound, etc.). Particular attention is given to multifunctional nanostructured materials that are pharmacologically active and that can be actuated by virtue of their magnetic, dielectric, optically-active, redox-active, or piezoelectric properties. This important reference resource will be of great value to readers who want to learn more on how smart nanoparticles can be used to create more effective treatment solutions. Nanotechnology has enabled unprecedented control of the interactions between materials and biological entities, from the microscale, to the molecular level. Nanosurfaces and nanostructures have been used to mimic or interact with biological microenvironments, to support specific biological functions, such as cell adhesion, mobility and differentiation, and in tissue healing. Recently, a new paradigm has been proposed for nanomedicine to exploit the intrinsic properties of nanomaterials as active devices rather than as passive structural units or carriers for medications. Discusses the synthesis, characterization and applications of a new generation of smart nanoparticles for nanomedicine applicationsExplores the problems relating to the biocompatibility of a range of nanoparticles, outlining potential solutionsDescribes techniques for manipulating specific classes of nanoparticles for a variety of treatment types"-- Provided by publisher.

Contents:
1. Introduction: Smart Materials in Biomedicine / Elisa Mele
2. Smart Polymeric Nanoparticles / Clara Mattu, Giulia Brachi, Gianluca Ciardelli
3. Smart Liposomes for Drug Delivery / Tianshu Li, Shinji Takeoka
4. Pharmacologically Active Plant-Derived Natural Products / Adela Pintea, Dumitriţa Rugină, Zoriţa Diaconeasa
5. Nanostructured Cyanoacrylates: Biomedical Applications / Ilker S. Bayer
6. Applications of Carbon Nanotubes in the Biomedical Field / Cécilia Ménard-Moyon
7. Carbon Nanomaterials for Nanomedicine / Marta d'Amora, Silvia Giordani
8. Silica Nanoparticle Applications in the Biomedical Field / Larissa B. Capeletti, Lívia M.D. Loiola, Agustin S. Picco, Michelle da Silva Liberato, Mateus B. Cardoso
9. Magnetic Nanoparticles and Their Bioapplications / Christos Tapeinos
10. TiO2 Nanotube Arrays as Smart Platforms for Biomedical Applications / Giada G. Genchi, Yiqi Cao, Tejal A. Desai
11. Antioxidant Inorganic Nanoparticles and Their Potential Applications in Biomedicine / Austin Burns, William T. Self
12. Zinc Oxide Nanostructures in Biomedicine / Luisa Racca, Marta Canta, Bianca Dumontel, Andrea Ancona, Tania Limongi, Nadia Garino, Marco Laurenti, Giancarlo Canavese, Valentina Cauda
13. Smart Inorganic Nanoparticles for Wireless Cell Stimulation / Attilio Marino, Matteo Battaglini, Ilaria Pezzini, Gianni Ciofani
14. Nanosized Optical Thermometers / Satoshi Arai, Madoka Suzuki
15. Advanced Optical Microscopy Techniques for the Investigation of Cell-Nanoparticle Interactions / Natalia Feiner-Gracia, Sílvia Pujals, Pietro Delcanale, Lorenzo Albertazzi.

Summary: This book provides information on how to extract the most from mobile applications and easily adapt and integrate them into daily practice. Today mobile applications that can optimize patient flow, help in examinations, perform anterior/posterior segment imaging, offer differential diagnosis and therapeutic options and even serve as patient drug reminders and councilors are easily available. Most of them have been developed by individuals and as a result lack marketing, even though they are free to download and use. Ophthalmology has always been at the forefront of medicine when it comes to adopting the latest developments -- be they lasers, off-label anti-VEGF drugs or biocompatible implants. Mobile phones and tablets have infiltrated our private and professional lives and they are here to stay. As such, this book explores the endless possibilities that mobile computing offers, and introduces the vista of opportunities for providing better care, one download at a time. As part of the series "Current Practices in Ophthalmology" this volume is intended for residents and fellows in-training, as well as general and specialist ophthalmologists.

Contents:
What are "smart devices"?
Social networking in ophthalmology
Apps and social networking pages for basic workup
Apps and social networking pages for lens disorders
Apps and social networking pages for glaucoma
Apps and social networking pages for retinal diseases
Apps and social networking pages for strabismus and pediatric ophthalmology
Apps and social networking pages for neuro-ophthalmology
Apps and social networking pages for oculoplasty and ocular trauma
Apps and social networking pages for ocular oncology
Teleophthalmology.

Contents:
Section I: Basic principles. A. Fundamentals.
Epidemiology of smell and taste dysfunction
B. Morphophysiology of the olfactory and nasal trigeminal sensory systems. Anatomy of the olfactory system
Development of the human olfactory system
Anatomy of the olfactory mucosa
Olfactory receptor function
Central olfactory structures
Taste and smell processing in the brain
The intranasal trigeminal system
Cranial nerve 13
C. Morphophysiology of the gustatory and oral trigeminal systems. Anatomy and development of the human taste system
Taste receptor function
Central taste anatomy and physiology
The orotrigeminal system
Section II: Clinical aspects. A. Clinical assessment
Health histories and medical evaluations of patients with complaints of chemosensory dysfunction
Psychophysical testing of smell and taste function
Electrophysiologic assessment of olfactory and gustatory function
Neuroimaging of smell and taste
B. Diseases and disorders. Diseases of the nasal cavity
Neurolocalization of taste disorders
Chemosensory dysfunction in neurodegenerative diseases
Systemic diseases and disorders
Toxic exposures and the senses of taste and smell
The influence of head injury on olfactory and gustatory function
Animal models of olfactory dysfunction in neurodegenerative diseases
C. Treatment and management of chemosensory disorders. Treatments for smell and taste disorders: a critical review.

Summary: Loss of the sense of smell or taste is often a sign of neurological disease. Evaluating chemosensation (the senses of smell and taste) during neurological examination can help early detection of neurodegenerative conditions such as Parkinson's and Alzheimer's disease. The importance of such testing is now receiving increasingly high profile in the medical curriculum. In this book, olfactory conditions are completely updated and the sense of taste is now included in similar detail. It is written by experts in the field, covering anatomy and physiology of human olfaction and taste, how they can be measured and their relevance to a wide range of major disorders such as diabetes, kidney disease, Alzheimer's and Parkinson's disease. The 'Olfactory Vector Hypothesis' that suggests a neuropathogen may enter the nose en route to the brain is evaluated in detail. This introduction to smell and taste disorders is an essential guide for neurologists, neurosurgeons, otolaryngologists, medical trainees, and chemosensory scientists.

Contents:
Section 1: Basic sciences. General principles of pharmacology
Data, statistics and clinical trials
Inhalational anaesthetics and medical gases
Intravenous anaesthetics and sedatives
Local anaesthetics
Pain
Nausea and vomiting
Muscle function and neuromuscular blockade
Cardiovascular system
Respiratory system
Renal system
Fluid, electrolyte and acid-base balance
Metabolism, the stress response and thermoregulation
Blood, coagulation and transfusion
Section 2: Physics and apparatus. Basic physics
Equipment
Clinical measurement and monitoring
Section 3: Fundamentals of anaesthesia & perioperative medicine. Quality and safety
Preoperative assessment
Coexisting disease
Consent and information
The practical conduct of anaesthesia
Airway management
Pain management
Local and regional anaesthesia
Complications
Management of critical incidents
Resuscitation
Postoperative care
Section 4: Clinical anaesthesia. The high-risk surgical patient
The older surgical patient
The obese patient
Paediatric anaesthesia
Day surgery
General, gynaecological and genitourinary surgery
Orthopaedic surgery
ENT, maxillofacial and dental surgery
Ophthalmic surgery
Vascular, endocrine and plastic surgery
Neurosurgery
Thoracic surgery
Cardiac surgery
Obstetric anaesthesia and analgesia
Emergency and trauma surgery
Anaesthesia in low and middle-income areas
Anaesthesia outside the operating theatre
Organ transplantation
Intensive care medicine.

Summary: Written and edited by renowned experts in pediatric anesthesia, Smith's Anesthesia for Infants and Children provides clear, concise guidance on effective perioperative care for any type of pediatric surgery. The 10th Edition contains significantly revised content throughout, bringing you fully up to date with recent advances in clinical and basic science that have led to changes in today’s clinical practice.

Contents:
Special Characteristics of Pediatric Anesthesia
Behavioral Development
Respiratory Physiology
Airway Physiology and Development
Cardiovascular Physiology
Regulation of Fluids and Electrolytes
Thermoregulation
Developmental Pharmacology
Intravenous Anesthetics
Inhaled Anesthetics
Local Anesthetics
Opioids
Neuromuscular Blocking Agents
Anesthetic Adjuncts
Psychological Aspects of Pediatric Anesthesia
Preoperative Preparation
Equipment
Monitoring
Normal and Difficult Airway Management
Point of Care Ultrasonography
Induction, Maintenance, and Recovery
Transfusion Medicine
Acute Pain Management
Regional Anesthesia
Chronic Pain Management
Palliative Pain Management
Neonatology for Anesthesiologists
Anesthesia for General Surgery in Neonates
Anesthesia for Fetal Surgery
Anesthesia for Congenital Heart Disease
Anesthesia for Neurosurgery
Anesthesia for Thoracic Surgery
Anesthesia for General Abdominal, Urologic Surgery
Anesthesia for Otorhinolaryngologic Surgery
Anesthesia for Plastic Surgery
Anesthesia for Orthopedic Surgery
Anesthesia for Ophthalmic Surgery
Solid Organ Transplantation
Anesthesia for Conjoined Twins
Anesthesia for Pediatric Trauma
Anesthesia for Burns
Anesthesia for Dental Procedures
Anesthesia and Sedation for Out of OR Procedures
Pediatric Sedation
Anesthesia for Surgical Missions
Endocrine Disorders
Respiratory Disorders
Cardiovascular Disorders
Hematology and Coagulation Disorders
Oncologic Disorders
Genetic and Muscular Disorders
Malignant Hyperthermia
Pediatric Obesity
Special Pediatric Disorders
Dermatology for the Anesthesiologist
Infectious Diseases
Cardiopulmonary Resuscitation
Critical Care Medicine
Cardiac Critical Care Medicine
Safety and Outcome in Pediatric Anesthesia
History of Pediatric Anesthesia
Medicolegal and Ethical Aspects of Pediatric Anesthesia
Education
Statistics

Summary: "A comprehensive, evidence-based introduction to the principles and practices of patient communication in a clinical setting Smith's Patient-Centered Interviewing, Fourth Edition presents a step-by-step methodology for mastering every aspect of the medical interview. Readers will learn how to confidently obtain from patients accurate biomedical facts, as well as critical personal, social, and emotional information, allowing them to make a precise diagnosis, develop effective treatment plans, and forge strong clinician-patient relationships. The most evidence-based guide available on the topic, Smith's Patient-Centered Interviewing, Fourth Edition applies the proven 5-step approach, which integrates patient- and clinician-centered skills to improve effectiveness without adding extra time to the interview duration. The book's user-friendly design features icons, boxed case vignettes, and use of color to highlight key points, and pedagogy includes learning an practice exercises in each chapter"-- Provided by publisher. "Our goal in this text is to present in a logical, step-by-step fashion the behaviors that are necessary to conduct an effective and efficient biopsychosocial interview. Interviewing is the most important and most difficult skill learners must master in their clinical careers. The book is designed for learners in medicine, advanced-practice nursing, physician assistant, and other health-related disciplines where communication and relational skills are central"-- Provided by publisher.

Contents:
Dysmorphology approach and classification
Recognizable patterns of malformation
Deletion, duplication, and microduplication syndromes identifiable using molecular technology
Very small stature, not skeletal dysplasia
Moderate short stature, facial, ± genital
Senile-like appearance
Early overgrowth with associated defects
Unusual brain and/or neuromuscular findings with associated defects
Facial defects as major feature
Facial-limb defects as major feature
Limb defect as major feature
Osteochondrodysplasias
Osteochondrodysplasia with osteopetrosis
Craniosynostosis syndromes
Other skeletal dysplasias
Storage disorders
Connective tissue disorders
Hamartoses
Ectodermal dysplasias
Environmental agents
Miscellaneous syndromes
Miscellaneous sequences
Spectra of defects
Miscellaneous associations
Genetics, genetic counseling, and prevention
Minor anomalies : clues to more serious problems and to the recognition of malformation syndromes
Normal standards.

Summary: This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets. To facilitate understanding, the volume is divided into five parts and covers 16 organs: airways, phasic muscle, tonic muscle, renal pelvis, ureter, urinary bladder, urethra, corporal tissue, prostate, uterus, oviducts, seminal vesicle, artery, vein, microvasculature, and lymphatic vessels. This structure will help readers to comprehend the most up-to-date information on the similarities and differences in the contractile mechanisms driving various smooth muscles as well as their potential manipulations in particular visceral organ pathologies. The vast advancements in gene, electrical recording, and imaging technologies in this field are also discussed, with review of past achievements and consideration of likely future developments. This book will be of worldwide interest to clinicians, students, and researchers alike.

Contents:
PART I: Gastrointestinal tract
Phasic muscle
Spontaneous electrical activity and rhythmicity in gastrointestinal smooth muscles
Tonic muscle (Sphincters)
Generation of tone by gastrointestinal sphincters
PART II: Urinary tract
Renal pelvis
Pacemaker mechanisms driving pyeloureteric peristalsis: modulatory role of interstitial cells
Ureter
Excitation-contraction coupling in ureteric smooth muscle: mechanisms driving ureteric peristalsis
Urinary Bladder
Spontaneous activity and the urinary bladder
Urethra
Spontaneous activity in urethral smooth muscle
PART III: Reproductive organs
Corporal tissue
Ion channels and intracellular calcium signalling in corpus cavernosum
Prostate
Generation and regulation of spontaneous contractions in the prostate gland
Seminal vesicle
Mucosa-dependent, stretch-sensitive spontaneous activity in seminal vesicle
Uterus
The myometrium - from excitation to contractions and labour
Oviducts
Myosalpinx contractions are essential for egg transport along the oviduct and are disrupted in reproductive tract diseases
PART IV: Blood vessels
Artery
Cellular and Ionic Mechanisms of Arterial Vasomotion
Vein
Venous Vasomotion
Microvasculature
Role of pericytes in the initiation and propagation of spontaneous activity in the microvasculature
Lymphatic vessels
Lymphatic vessel pumping
PART V: Airways
Regulation of airway smooth muscle contraction in health and disease.

Summary: "This book provides health science students a review of basic anatomy in a strong clinical context. The book is heavily illustrated. Most figures have been kept simple in order to convey the fundamental floor plans that underlie the organization of body regions. Illustrations summarizing the nerve and blood supply of regions have been retained, as have overviews of the distribution of cranial nerves"--Provided by publisher.

Contents:
Introduction
The back
Upper limb
Thorax, Part I: Thoracic wall
Thorax, Part II: Thoracic cavity
Abdomen, Part I: Abdominal wall
Abdomen, Part II: Abdominal cavity
Pelvis, Part I: Pelvic walls
Pelvis, Part II: Pelvic cavity
Perineum
Lower limb
Head and neck.

Summary: "This book contains the basic neuroanatomical facts necessary for the practice of medicine. It is suitable for medical students, dental students, nurses, and allied health students. Residents find this book useful during their rotations. The functional organization of the nervous system has been emphasized and indicates how injury and disease can result in neurologic deficits. The amount of factual information has been strictly limited to that which is clinically important"--Provided by publisher.

Contents:
Introduction and organization of the nervous system
Neurons and neuroglia
Nerve fibers and peripheral innervation
Spinal cord and ascending, descending, and intersegmental tracts
Brainstem
Cerebellum and its connections
Cerebrum
The structure and functional localization of the cerebral cortex
Reticular formation and limbic system
Basal nuclei (Basal Ganglia)
Cranial nerve nuclei
Thalamus
Hypothalamus
Autonomic nervous system
Meninges
Ventricular system and cerebrospinal fluid
Blood supply of the brain and spinal cord
Nervous system development
Appendix: Neuroanatomical data of clinical significance and clinical neuroanatomy techniques.

Contents:
Will I have to wear a suit? rethinking life after graduate school
Getting your head ready
Should I finish my dissertation?
How to use your grad school years wisely
So what am I going to do?
Myths about post-academic careers
Questions about graduate school and your future
Your eclectic mix
Post-academic profile: Abby Markoe, A.B.D. history of medicine, executive, director
Squashwise
How do I figure out what else to do? soul-searching before job searching
Take inventory
Break it down
Looking backward: seven stories
Guilty pleasures
"This is your brain on graduate school"
No need for a #2 pencil
Where are all those PhDs anyway?
Create your own possibilities
Post-academic profile: Samantha Sutton, PhD in biology, life coach
Asking the big questions: how to figure out if you want them and if they want you
Asking the big questions
Answering the big questions: three strategies
Transitional tales
So what's next?
Post-academic profile: Xiuwen Tu, PhD in physics, Sun Power Corporation, device and characterization engineer
This might hurt a bit: turning a CV into a résumé
Getting ready to write a résumé
Writing a résumé: the first draft
A few more words of advice
After you've drafted a résumé
Case studies and sample résumés
Cover letters that will get you hired
Post-academic profile: Alyssa Picard, PhD in history, staff representative for the Michigan Affiliate of the American Federation of Teachers
Sweaty palms, warm heart: how to turn an interview into a job
Before the interview
During the interview
After the interview
What if the interview doesn't go well?
The job offer (or lack thereof)
Negotiation
Adjusting to your new job
Post-academic profile: Scott Keeter, PhD in political science, director of Survey Research, Pew Research Center for the People & the Press
Conclusion.

Contents:
Why is collecting a blood sample important?
You and your patient
How do you protect your patient and yourself using standard precautions?
Sterility
Disposal of used materials
What is blood?
Recommended volume limits for a single blood draw
How is blood collected?
Blood collection equipment
The phlebotomy area
The test requisition
Representative blood collection tubes
Timed specimens
Approaching the patient
The venipuncture from an arm vein
Recommended order of draw for multiple specimen collection
The difficult venipuncture
Intravenous fluids and the venipuncture
Collection of venous blood gases
Identification and labeling of the blood specimen tube
The difficult patient
The missing patient
The patient has a reaction
The skin puncture
Obtaining blood from babies
The blood smear
The blood culture
Collecting blood specimens under special circumstances
Your safety
Competency assessment
Your attitude
Appendix 1: Drawing blood from existing intravascular devices
Appendix 2: Intraosseous cannulation used for blood analysis and infusion
Appendix 3: Aids for visualizing veins under the skin
Appendix 4: Ultrasound-guided peripheral intravenous cannulation
Appendix 5: Quality assurance
Appendix 6: Additional resources.

Summary: In this New York Times bestseller, Ijeoma Oluo offers a hard-hitting but user-friendly examination of race in America. Widespread reporting on aspects of white supremacy--from police brutality to the mass incarceration of Black Americans--has put a media spotlight on racism in our society. Still, it is a difficult subject to talk about. How do you tell your roommate her jokes are racist? Why did your sister-in-law take umbrage when you asked to touch her hair--and how do you make it right? How do you explain white privilege to your white, privileged friend? In So You Want to Talk About Race, Ijeoma Oluo guides readers of all races through subjects ranging from intersectionality and affirmative action to "model minorities" in an attempt to make the seemingly impossible possible: honest conversations about race and racism, and how they infect almost every aspect of American life.

Contents:
Introduction : so you want to talk about race
Is it really about race?
What is racism?
What if I talk about race wrong?
Why am I always being told to "check my privilege"?
What is intersectionality and why do I need it?
Is police brutality really about race?
How can I talk about affirmative action?
What is the school-to-prison pipeline?
Why can't I say the "N" word?
What is cultural appropriation?
Why can't I touch your hair?
What are microaggressions?
Why are our students so angry?
What is the model minority myth?
But what if I hate Al Sharpton?
I just got called racist, what do I do now?
Talking is great, but what else can I do?

Summary: "This book is about depression in children and teenagers during their school years, from 5 to 18. It is written primarily for parents, but we hope that teachers, social workers, health visitors and family doctors will also find it useful. Why do parents need to know about possible depression in their children? All children get sad and miserable from time to time. Sometimes it is difficult to know if such normal unhappiness needs special attention. We aim to help parents in this situation. This is an example of a situation in which a mother describes how first she thought her son's problem was nothing much to worry about but then she had to change her mind: Ben's mother, a teacher, described the change that came over her ten-year-old son after a short viral illness"-- Provided by publisher.

Summary: "Offering step by step guidance on how to properly document patient care, the Third Edition of SOAP for Family Medicine presents 90 of the most common clinical problems encountered on the wards and clinics in an easy-to-read, two-page layout, using the familiar "SOAP" note format. Emphasizing the patient’s clinical problem, not the diagnosis, this pocket-sized quick reference teaches both clinical reasoning and documentation skills and is ideal for use by medical students, PAs, and NPs during the Family Medicine rotation." -- Provided by the publisher.

Contents:
I: Medicine
II: Obstetrics & Gynecology
III: Pediatrics
IV: Dermatology
V: Orthopedic Conditions
VI: Psychiatry/Psychosocial Issues

Contents:
-- I: Medicine
II: Obstetrics & Gynecology
III: Pediatrics
IV: Dermatology
V: Orthopedic Conditions
VI: Psychiatry/Psychosocial Issues

Summary: "Rather than attempting to summarize the contents of a thousand-page textbook into a miniature form, the SOAP series focuses exclusively on guidance through patient encounters. In a typical use, "finding out where to start" or "refreshing your memory" with SOAP books should be possible in less than a minute. Subjects are always confined to two pages, and the most important points have been highlighted. Topics have been limited to those problems you will most commonly encounter repeatedly during your training, and contents are grouped according to the hospital or clinic setting. Facts and figures that are not particularly helpful to surviving life on the wards, such as demographics, pathophysiology, and busy tables and graphs have purposely been omitted (such details are much better studied in a quiet environment using large and comprehensive texts)"-- Provided by publisher.

Summary: Recognising the structures on the dissection, understanding their relationships and gainingan overview of how they work together assures confident study and transition into clinical practice. The Sobotta Atlas shows authentic illustrations of the highest quality, drawn from genuine specimens, guaranteeingthe best preparation for the gross anatomy class and attestation.

Contents:
General anatomy
Trunk
Upper limb
Lower limb.

Summary: "The Sobotta Atlas shows authentic illustrations of the highest quality, drawn from genuine specimens, guaranteeing the best preparation for the gross anatomy class and attestation. Sobotta focuses on the basics, making it comprehensive. Every tiny structure has been addressed according to current scientific knowledge and can be found in this atlas"-- publisher's description.

Contents:
Organs of the thoracic cavity
Organs of the abdominal cavity
Retroperitoneal space and pelvic cavity.

Contents:
Head
Eye
Ear
Neck
Brain and spinal cord.

Contents:
Head
Neck
Trunk
Upper limb
Lower limb
Cranial nerves.

Summary: "Social (In)Justice and Mental Health introduces readers to the concept of social justice and role that social injustice plays in the identification, diagnosis, and management of mental illnesses and substance use disorders. Unfair and unjust policies and practices, bolstered by deep-seated beliefs about the inferiority of some groups, has led to a small number of people having tremendous advantages, freedoms, and opportunities, while a growing number are denied those liberties and rights. The book provides a framework for thinking about why these inequities exist and persist and provides clinicians with a road map to address these inequalities as they relate to racism, the criminal justice system, and other systems and diagnoses. Social (In)Justice and Mental Health addresses the context in which mental health care is delivered, strategies for raising consciousness in the mental health profession, and ways to improve treatment while redressing injustice"-- Provided by publisher.

Contents:
Social (In)Justice and Mental Health / Ruth S. Shim, Sarah Y. Vinson
Social Injustice and the Social Determinants of Mental Health / Ruth S. Shim, Michael T. Compton
Social Injustice and Mental Health Inequities / Sonya M. Shadravan, Nicolás E. Barceló
Social Injustice and Structural Racism / Matthew L. Edwards, Samuel Ricardo Saenz, Roy Collins, Belinda Bandstra
Social Injustice and the Schooling System / Tiffani Marie, Brennin Y. Brown
Social Injustice and the Child Welfare System / Melissa D. Carter, Courtney L. McMickens
Social Injustice and Urban Development / Jacob Michael Izenberg, Mindy Thompson Fullilove
Social Injustice and the Carceral System / LeRoy E. Reese, Seyi O. Amosu, Sarah Y. Vinson
Social Injustice and the Health Care System / Michelle Ko, Angie Lisbeth Cruz, Janet R. Cummings
Social Injustice and Substance Use Disorders / Jessica Isom, Sonya M. Shadravan, Melvin Wilson
Social Injustice and Schizophrenia / Khalima A. Bolden, Poh Choo How, Swati Rao, Deidre M. Anglin
Social Injustice and Personality Disorders / David Freedman, George W. Woods
Social Injustice and Child Trauma / Walter E. Wilson Jr., Nicole Cotton, Sarah Y. Vinson
Social Justice and Mental Health System Reform / Phillip Murray, Ruth S. Shim
Social Justice and Advocacy / Kali D. Cyrus, Sarah Y. Vinson
Social Justice and Mental Health : A Call to Action / Sarah Y. Vinson, Ruth S. Shim.

Contents:
Preface
A Brief History of Social Psychiatry
Psychiatric Epidemiology and its Applications in Social Psychiatry
Global Mental Health
Psychiatric Reform in Europe
Psychiatric Reform in Greece
Psychoanalysis and public psychiatric care
Mental Health Promotion: good practice in community settings
Social Exclusion and Mental Health in Metropolitan Athens
Psychosocial Rehabilitation and the Recovery Model: Applications in residential units in the community
Mobile Mental Health Units in the Cyclades Islands: Mental Health Care for Adults
Mobile Mental Health Units in the Cyclades Islands: Mental Health Care for Children and Adolescents
A Modern Day Care Centre in Athens
ACT and Home Care
Counselling and Psychodynamic Psychotherapy in community settings
Mental Health Care of itinerant populations in the community
Modern Technologies and Social Psychiatry
Domestic Violence and Mental Health Services in the community: Management and Evaluation
Sexuality in individuals with severe mental illness at PSR units
Evaluating Social Psychiatry Services
Implications of the Socioeconomic Crisis for Staff in Community PSR units: the case of an NGO
Staff Evaluation and Organizational Culture in Mental Health Units
Participation and Empowerment of Users and Families
Involuntary Hospitalization: Legal context, Epidemiology and Outcome
Mental Health and the Financial Crisis.

Summary: This volume brings together research into diverse aspects of social anxiety and its clinical form, social phobia, in adolescents. Development of the condition, clinical manifestations, and evidence-based prevention and treatment strategies are all addressed, with emphasis on ways in which adolescent development and the broader family and peer context are reflected in the manifestation and treatment of symptoms. The first part of the book reviews epidemiological, neurobiological, and sociopsychological research on vulnerability factors that aim to clarify why both social anxiety and phobia intensify in adolescence. The second part focuses on the phenomenology of social anxiety and phobia in different developmental contexts and provides the reader with a review of developmentally-appropriate evidence-based assessment methods. For example, this section includes chapters on social anxiety in the school environment and in romantic relationships, social phobia in the clinical setting. The third section reviews the psychosocial prevention and treatment options for adolescent social anxiety as well as the psychopharmacological treatment of social phobia. Social Anxiety and Phobia in Adolescents will be informative and interesting for all child and adolescent psychiatrists, clinical psychologists, and psychotherapists as well as for school psychologists and counsellors.

Contents:
Background/Theoretical Accounts: The developmental psychopathology of social anxiety and phobia in adolescents
Developmental Epidemiology of Social Anxiety and Social Phobia in Adolescents
Easier to Accelerate Than to Slow Down: Contributions of Developmental Neurobiology for the Understanding of Adolescent Social Anxiety
Developmental Transitions in Adolescence and their Implications for Social Anxiety
Recognition and Manifestations of Adolescent Social Anxiety and Phobia in Diverse Settings: Assessment of Social Anxiety in Adolescents
Social Anxiety and the School Environment of Adolescents
Social Anxiety and Romantic Relationships
Adolescent Social Phobia in Clinical Services
Cognition-focused Interventions for Social Anxiety Disorder Among Adolescents
Interpersonal Approaches to Intervention: Implications for Preventing and Treating Social Anxiety in Adolescents
School-based Interventions for Adolescents with Social Anxiety Disorder
Social Skills-based Treatment for Social Anxiety Disorder in Adolescents
Pharmacotherapy for Adolescent Social Phobia
Concluding Remarks.

Summary: Social Cognition and Interaction Training (SCIT) is a group psychotherapy for individuals with schizophrenia and other psychotic disorders.

Summary: Drawing from the work of academics and practitioners from ten states across the country, this edited volume showcases and synthesises the diversity and richness of efforts to understand and act on the social determinants of health in India, the conditions in which we are born, grow, live work and age. Such an effort is salient in the current era of Sustainable Development Goals (SDG), which have foregrounded the issue of equity and the need for a comprehensive, multi-sectoral agenda for health and development. In India, particularly in the last decade, there have been myriad efforts to more critically theorise and intervene in areas with bearing on health, like conflict, nutrition or urbanisation, or to address the concerns of vulnerable groups like women, children and the elderly. From these efforts emerge lessons of convergence for academic and policymaking institutions in India who are looking to operationalise and bring life to the SDG agenda in India and other Low and Middle Income Country settings. The book comprises eleven chapters and six short commentaries that appear in conversation with each other, as well as an annexure of validated, ready to use indicators for monitoring of social determinants of health.

Summary: This open access book is the first compilation that reviews a wide range of social determinants of health (SDHs) for non-communicable diseases (NCDs) and healthy ageing in Japan. With the highest life expectancy and the largest elderly population in the world, Japan has witnessed health inequality by region and social class becoming more prevalent since the 2000s. The first half of this volume describes in detail major NCDs, such as cancers, heart and kidney diseases, diabetes, stroke, and metabolic syndrome. The second half, on the other hand, explores various SDHs relating to healthy ageing. All chapters review and focus on SDHs, particularly health inequality associated with socio-economic status and social capital, which are widely addressed in the field of social epidemiology. The book makes the argument that "Health for All" advocated by the WHO should be implemented based on social justice and benefits for the greater society. Public health researchers and policymakers, both in Japan and other nations, will gain scientific evidence from this book to prepare for the coming era as ageing becomes a global issue. Katsunori Kondo is Professor of Social Epidemiology and Health Policy, Center for Preventive Medical Sciences and the Graduate School of Medicine, Chiba University, Japan. He is also Head of Department of Gerontological Evaluation at the Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology. .

Contents:
Acknowledgements
Preface
Table of Contents
Editor Bio
The Social Determinants of Health and Trends Concerning Health Disparity
Behavioral Problems in Children
Metabolic Syndorome
Cancer and Socioeconomic Status
Coronary Heart Disease
Stroke
Chronic kidney disease
Diabetes Mellitus
Suicide
Depression
Dementia
Falls and Related Bone Fractures
Malnutrition in Older People
Oral Health
Healthy aging:IADL and functional disability
Life Course Epidemiology
Social capital and health
Access to Healthcare and Health Inequality
Measures of Health Inequality and Health Impact Assessment
What Measures Can Be Taken to Reduce Health Disparity?
Recommendations
Ministeral notification
Monitoring report (1)
Monitoring Report (3)
Monitoring Report (5)
Monitoring Report (8)
Index.

Summary: "Social determinants of health has been defined by the World Health Organization as the conditions in which people are born, grow, live, work, and age. These determinants can include factors such as housing, transportation, education, employment, and access to care. Social Determinants of Health: A Primer for the Practicing Surgeon provides a comprehensive, state-of-the art, definitive reference for the surgical community on this important topic, serving as an invaluable resource for surgeons, physicians, fellows, and residents. Offers unique, practical content from experts in the field, with up-to-date information from both national and world leaders. Covers various aspects of social determinants of health related to the surgical field, including internalization of social determinants of health; social determinants of health and disease initiation, progression, and outcomes; and social determinants of health from a research perspective. Contains chapters on a wide range of topics as social determinants of health in surgery, including intersectionality, insurance, stress, finances, neighborhood, healthcare access, community engagement, literacy, and more. Discusses study design and outcomes, interventions, and future directions in social determinants of health in surgery. Consolidates today's available information on this timely topic into a single, convenient resource.

Contents:
Social Determinants of Health in Surgery Overview
Internalizing Social Determinants of Health: The Ecosocial and Weathering Theories
Allostatic Load--Measurement Issues in Cancer Patients and Other Populations
The Conserved Transcriptional Response to Adversity : Prepared for Social Determinants of Health in Surgery
Finances as a Social Determinant of Health in Surgery
Neighborhood as a Social Determinant of Health in Surgery
Addressing the Social Determinants of Health to Enhance Clinical Trial Participation
Race, Ancestry, and Social Determinants of Health in Surgery
Community Engagement as a Social Determinant of Health in Surgery
Insurance as a Social Determinant of Health in Surgery
Health Literacy
Psychological Stress and the Surgical Stressor
Framing Theoretically Informed Social Determinants of Health Research Questions
Social Determinants of Health: Study Designs and Outcomes
Interventions for Redressing Disparities Related to Social Determinants of Health in Surgery
Future Directions.

Summary: Human societies are influencing nature in such a way that their independent analysis is no longer suitable. Fortunately, social-ecological systems provide a conceptual framework for the interconnected analysis of societies and ecosystems. However, in the case of Latin America, the complexity of social-ecological processes undermined a much-needed compilation of theoretical concepts, methods and case studies. Increasing readers understanding of such systems using a postnormal approach, the book discusses current concepts and methods with examples of studies from eight countries. It is a useful resource for social actors, government decision makers and scholars.

Contents:
Chapter 1
Social-ecological systems and postnormal science
Chapter 2
Studying social-ecological systems from the perspective of social sciences in Latin America
Chapter 3
Simplifying the complexity of social-ecological systems with conceptual models
Chapter 4
Social actors and participative modelling
Chapter 5
Social-ecological systems and human wellbeing
Chapter 6
Poor-people ecologism
Chapter 7
A new environmental governance
Chapter 8
A hierarchical approach for the valuation of multiple ecosystem services
Chapter 9
Novel ecosystems and social-ecological complexities
Chapter 10
Social-ecological systems and the economy of nature: A Latin-American perspective
Chapter 11
Spatial modelling of social-ecological systems: The Arroyo las Conchas watershed, Argentina
Chapter 12
Analyzing social vulnerability to natural disasters in northeast Brazil: catastrophic flooding cycles at Alagoas littoral zone
Chapter 13
San Rafael Reserve, Paraguay: key social actors and sustainability scenarios through environmental governance schemes
Chapter 14
Valuation of hydrological supply in high Andes wetlands of Chinchiná River, Colombia
Chapter 15
Participative management and local institutional strengthening: the successful case of mangle social-ecological systems in Ecuador
Chapter 16
Integrated assessment of the effects of the payment for hydrological services program at Ajusco, Mexico City
Chapter 17
Influence of the rural/urban context in the implementation of forest conservation programs in Mexico: Oaxaca and Mexico City case studies
Chapter 18
Characterizing social-ecological traps: A case study of forest and marine systems in Southern and Austral Chile
Chapter 19
Ecosystem services from a multi-stakeholder perspective: a case study in a Biosphere Reserve in central Chile
Chapter 20
Restoration of riverside forests: contributing to the fisheries management of river Pich is watershed, central jungle, Perú
Chapter 21
The challenge of integrated management of Isla de Chiloé coastal zone
Chapter 22
Social valuation of ecosystem services at local scale: challenges for the management of a multiple-use coastal and marine protected area (MU-CMPA): Isla Grande de Atacama
Chapter 23
Potential futures of social-ecological systems in Latin America.

Contents:
1. Discovering social ecology: a personal journey
2. Historical origins and conceptual foundations of social ecology
3. Deriving core principles of social ecology
4. Rise of the internet- navigating our online and place-based ecologies
5. Promoting personal and public health
6. Confronting complex social problems
7. Managing global environmental change
8. Designing resilient and substainable communities
9. Educating the next generation of social ecologists
10. Epilogue.

Summary: Social Emergency Medicine incorporates consideration of patients social needs and larger structural context into the practice of emergency care and related research. In doing so, the field explores the interplay of social forces and the emergency care system as they influence the well-being of individual patients and the broader community. Social Emergency Medicine recognizes that in many cases typical fixes such as prescriptions and follow-up visits are not enough; the need for housing, a safe neighborhood in which to exercise or socialize, or access to healthy food must be identified and addressed before patients health can be restored. While interest in the subject is growing rapidly, the field of Social Emergency Medicine to date has lacked a foundational text a gap this book seeks to fill. This book includes foundational chapters on the salience of racism, gender and gender identity, immigration, language and literacy, and neighborhood to emergency care. It provides readers with knowledge and resources to assess and assist emergency department patients administrators, and other professionals who recognize that high-quality emergency care extends beyond the ambulance bay.

Contents:
1. History of Social Emergency Medicine
2. Public Health, Population Health, and Health Disparities
3. Race and Racism
4. Gender and Sexual Identity
5. Immigration
6. Language and Literacy
7. Access to Care
8. Frequent Emergency Department Use: A Social Emergency Medicine Perspective
9. Substance Use: A Social Emergency Medicine Perspective
10. Education and Employment
11. Financial Insecurity
12. Food Insecurity
13. Homelessness
14. Housing Instability and Quality
15. Transportation
16. Legal Needs
17. Neighborhoods and the Built Environment
18. Violence
19. Firearm Injury
20. Incarceration
21. Human Trafficking.

Summary: "A quarter century has elapsed since the first edition of this book was published. Since then an enormous body of research has appeared concerning biological and psychological risk factors for personality disorders (PDs), as well as for biological and psychological methods of treatment. However, less attention has been paid to the social context of PDs, i.e., how personality traits and disorders interact with social demands and opportunities. Yet social forces carry important risks for the development of PDs. Personality disorders are rooted in traits. We all have a personality. But it need not become disordered if we can find a social niche that fits our particular characteristics. If we do not find that niche, then psychopathology is more likely to ensue. That is one of the main themes of this new edition. The argument of this book will be backed up by research. Personality traits are heritable variants that lie within a normal range: adaptive under some circumstances but maladaptive under other circumstances. About half of the variance in personality and personality disorders is under genetic influence. Levels of psychosocial risk are complex: some derive from dysfunctional families, but most of the variance is not related to growing up in a specific family. The larger social environment plays a crucial role of its own"-- Provided by publisher.

Contents:
The case for social marketing in public health / Jeff French
Key principal, concepts, and techniques of social marketing / Jeff French
Social marketing planning / Jeff French
Evaluation of social marketing programmes / Adam Crosier and Dominic McVey
Social marketing and public health strategy / Jeff French
Behaviour and how to influence it / Jeff French
Generating insight and building segmentation models in social marketing / Dominic McVey and Adam Crosier
Commissioning social marketing / Jeff French
Social marketing on a small budget / Jeff French
Building social programme coalitions / Jeff French
Ethical issues in social marketing / Lynne Eagle, Stephan Dahl, and David Low
Using digital and social media platforms for social marketing / Melissa K. Blair
Social franchising: Strengthening health systems through private sector approaches / Julie McBride, Kim Longfield, Dana Sievers, and Dominic Montagu.

Summary: Medical professionals are increasingly engaging with social media in an effort to provide credible evidence-based information and combat the misinformation that patients are finding online and bringing to office visits. Medical professionals are uniquely poised to recognize the harm that can come from applying the incorrect information to decisions affecting ones health, while they are also able to serve as valued and knowledgeable experts online and engage with patients and the public to provide accurate, up-to-date information. Social Media for Medical Professionals: Strategies for Successfully Engaging in an Online Worldis a unique, first-of-its-kind resource, providing specific social media strategies for engagement, as well as advice regarding best practices for professionals to maintain at all times. Chapters discuss many aspects pertaining to social media, covering the basics, researching and assessing credible medical information online, and best practices for discussing myths and misconceptions with patients. Later chapters cover the benefits of engaging in social media as a medical professional, strategies for increasing engagement and building an audience, various options and platforms for content creation and finding your niche, doss and donts regarding patient privacy, and strategies for dealing with negative comments online. A uniquely practical resource, Social Media for Medical Professionals: Strategies for Successfully Engaging in an Online World will be of interest to medical professionals across the spectrum of healthcare, from the student to the seasoned clinician, providing valuable perspective on practicing medicine in an evolving digital world.

Contents:
Introduction: What is social media? (Overview of the platforms, ways they are utilized)
Finding medical information online in the digital age (Details about patients using online resources for medical information)
Myths and misconceptions (Dangers of searching online for medical information)
Why should medical professionals get involved? (Benefits of engaging in social media) . Start with a target audience (Who are you trying to reach, how does message change by audience)
If you Tweet it, they will come (Strategies to increase engagement and build a following) .-Content curation (How to identify and use information from credible resources)
Content creation (Discuss all the platforms to build an assortment of content; blog posts, podcasts, YouTube and how to cross promote on social media)
Dos and donts for the medical professional (Patient privacy, subject matter)
How to deal with trolls (Strategies for dealing with negative comments/feedback)
The sky is the limit (Ideas for how to take social media to other venues, promotion in academic centers, research).

Summary: Today's teens are often referred to as Digital Natives due to their upbringing immersed in technological tools including smartphones and social media, while most of us who provide healthcare for this group remain at best, digital immigrants. These technologies present both new opportunities and challenges to teens' health, as well as their education and life experiences. Pediatricians can play a key role in helping teens and their families navigate critical issues such as balancing online and offline lives, as well as understand links between media and health. This issue of AM:STARS is mean.

Summary: "The book's overarching message is an important one: The experience of most people with disabilities is not what nondisabled persons anticipate--contrary to the latter's beliefs and expectations, the former can lead full and normal lives. Thus, The Social Psychology of Disability is designed to counter stereotypical or biased perspectives aimed at an often overlooked minority group."--Publisher information.

Contents:
Overview: The social psychology of disability
Fundamental psychosocial concepts for understanding disability
Challenges: stigma, stereotyping, and disability
Attitudes toward people with disabilities
Coping with and adjusting to disability
Towards an understanding of disability identity
A positive psychology of disability and rehabilitation
The ecology of disability.

Summary: Using current societal dilemmas, this book explores how social factors and social identity influence our health and recovery from illness. It includes recent research to present practitioners, researchers, policymakers and students of many disciplines with the material to support them in better harnessing current knowledge of the impact of social factors on health. The contents will influence collaborative working across policy, disciplinary and practice boundaries to design and deliver healthcare services. The book identifies the importance of social connectedness, social support, agency and self and group efficacy in people's health, longevity and resilience after adversity. Core perspectives include the social identity approach and a values framework for taking public health ethics into decision-making, both of which emphasise valuing people and co-productive relationships. Advocating better targeted mental health promotion and integrated interventions, this book strongly argues for a greater emphasis on social factors in evidence-based and cost-effective practice.

Summary: This book presents state-of-the-art research methods, results, and applications in social media and health research. It aims to help readers better understand the different aspects of using social web platforms in health research. Throughout the chapters, the benefits, limitations, and best practices of using a variety of social web platforms in health research are discussed with concrete use cases. This is an ideal book for biomedical researchers, clinicians, and health consumers (including patients) who are interested in learning how social web platforms impact health and healthcare research.

Contents:
1. A literature Review of Social Media-based Data Mining for Health Outcomes Research
2. Social Media-Based Health Interventions: Where Are We Now?
3. Quantifying and Visualizing the Research Status of Social Media & Health Research Field
4. Social Media in Health Communication
5. Consumers' Selection of Sources in Searching for Health Information
6. Understanding and Bridging the Language and Terminology Gap between Health Professionals and Consumers using Social Media
7. Dissemination of Information on Stigmatized Health Issues on Social Media
8. Learning Wellness Profiles of Users on Social Networks: The Case of Diabetes
9. Social Media and Psychological Disorder
10. Content Analysis of the 2015 #SmearForSmear Campaign Using Deep Learning
11. How to Improve Public Health via Mining Social Media Platforms: A Case Study of Human Papillomaviruses (HPV)
12. Learning Hormonal Therapy Medication Adherence from an Online Breast Cancer Forum
13. Ethics in Health Research using Social Media.

Summary: This volume describes the impact of headache disorders on public health, and their adverse consequences for society. It opens with an overview of relevant headache disorders before describing, qualitatively, how the burdens attributable to these disorders fall upon adults, adolescents and children. In the second section, beginning with a methodological introduction discussing the principles and potential pitfalls of epidemiological studies assessing prevalence, headache-attributed burden and functional impact, the burdens of headache including financial cost are examined quantitatively and in detail. The third section critically reviews society's response, its inadequacies and the scope for improvement. Topics here include the political failure to recognize the public ill-health and cost that are the consequences of inadequate headache care; the role of the WHO in addressing the problem; headache service organization, delivery and quality; and the effectiveness and cost-effectiveness of interventions. The book closes by considering the way forward. This volume contains important messages for primary care and is likely to be of even greater interest to headache specialists and those concerned with public health and health policy. -- Provided by publisher.

Contents:
1 Introduction
PART I HEADACHE and public health 2 The meaning of "headache" in the context of society (overview of headache disorders with societal impact)
3 Headache-attributed burden (the qualitative components)
4 Global surveys: WHO's Atlas of headache disorders and resources in the world
5 Global surveys: GBD 2010
PART II METHODOLOGIES 6 Headache epidemiological studies (a summary of the principles and recommendations with focus on pitfalls)
7 Quantifying headache-attributed burden (specific measures, such as symptom and disability burdens, including headache yesterday, interictal burden, cumulative burden, willingness to pay; generic measures such as quality of life; HARDSHIP)
8 Headache, functional impact and environment (ICF). PART III CONSEQUENCES FOR SOCIETY 9 Epidemiology and burden of headache (published studies to 2007 + LTB studies)
10 Cost (financial cost, including Eurolight)
PART IV SOCIETY'S RESPONSE 10 Political insouciance (the failure to recognize headache as a major cause of public ill-health and societal cost, including messages from WHO's Atlas of headache disorders and resources in the world)
11 Responding with the support of WHO (the Global Campaign against Headache)
12 Societal intervention: headache service organization and delivery
13 Societal intervention: headache service quality
14 Interventions (effectiveness and cost-effectiveness)
15 The way forward.

Summary: This volume examines the most important socio-cultural, political, economic, and policy issues related to emerging infectious diseases in Africa. The volume covers the work of the Global Emerging Pathogens Treatment Consortium (GET); it looks at the challenges of science education and communication in Africa, the global health and governance of pandemics and epidemics, and more. It looks beyond such threats as Ebola, SARS, and Zika to consider the ways communities have sought to contain these and other deadly pathogens. The chapters provide a better understanding of a global health problem from an African perspective, which help clarify to readers why some responses have worked while others have not.Overall, the volume captures the state of the art, science, preparedness, and evolution of a topic important to the health of Africa and the world. It has a broad appeal across disciplines, from medical science and biomedical research, through research ethics, regulation and governance, science and health communication, social sciences, and is also of interest to general readers.

Contents:
Chapter 1: Introduction to socio-ecological dimensions of infectious diseases and health in Southeast Asia.
Part 1: Infectious Diseases and Societies
Chapter 2: Climate, environment and epidemic febrile diseases: A view from Chinese medicine
Chapter 3: Long life of people living with HIV/AIDS and the practice of medical power
Chapter 4: Socio-environmental global changes and infectious diseases: Interdisciplinary approach applied to tourism studies
Part 2: Socio-Ecosystems and Health
Chapter 5: Heavy metals contamination in the ecosystem of Mae Tang reservoir in Northern Thailand
Chapter 6: Water and health: What is the risk and visible burden of the exposure to environmental contaminations? Insights from a questionnaire-based survey in Northern Thailand
Chapter 7: Melioidosis in Laos
Part 3: Global Changes, Land Use Changes and Vector-Borne Diseases
Chapter 8: Adaptation of mosquito vectors to salinity and its impact on mosquito-borne disease transmission in the South and Southeast Asian tropics
Chapter 9: The malaria landscape: Mosquitoes, transmission, landscape, insecticide resistance and integrated control in Thailand
Chapter 10: Rubber plantations as a mosquito box amplification in South and South-East Asia
Part 4: Monitoring and Data Acquisition
Chapter 11: Rescuing public health data
Chapter 12: The new science of metagenomics and the challenges of its use in both developed and developing countries
Chapter 13: Barcoding, biobanking, e banking: From ecological to ethical and legal aspects. Insights from the PathodivSEA project
Part 5: Managing Health Risks
Chapter 14: Methods for prioritization of diseases: Case study of zoonoses in South-East Asia
Chapter 15: Managing global risks: Vietnamese poultry farmers and avian flu
Chapter 16: The OIE Strategy to address threats at the interface between humans, animals and ecosystems
Part 6: Developing Strategies
Chapter 17: Business for biodiversity and ecosystem services
Chapter 18: Bridging the gap between conservation and health
Chapter 19: Implementation of the One health strategy. Lessons learnt from community based natural resource programs for communities' empowerment and equity within an Eco health approach.

Summary: A health and social science resource that consists of data sources suitable for use with statistical software; each consists of one or more data files, related documentation, and SAS and SPSS program statement files. Additionally includes evidence-based interventions & programs and professional education & capacity building tools.

Summary: This pocket book is the first of its kind on sodium fluoride (18F-NaF)-PET and addresses skeletal as well as cardiovascular applications. In malignant metastatic diseases 18F-NaF-PET has already demonstrated its benefits in cancer staging, re-staging, follow-up and response evaluation. It also has an emerging diagnostic role in the calcified soft-tissue metastases of primary bone tumours, and can be applied to evaluate cardiovascular diseases, such as calcifications in heart valves and peripheral vascular disease. The book is divided into 11 chapters: five on oncology, four addressing the general aspects of skeletal conditions, and two on cardiovascular diseases. It offers a valuable guide for referring colleagues, nuclear medicine physicians/radiologists and aid clinicians, and highlights the main applications and limitations of 18F-NaF-PET hybrid imaging (PET/CT).

Contents:
18F-Fluoride Imaging: Tracer and Technique
18F-Fluoride Imaging: Normal variants and artefacts
Sodium fluoride imaging in oncology
18F-Fluoride Imaging: Monitoring therapy
Determination of Skeletal Tumor Burden on 18F-Fluoride PET/CT
18F-Fluoride: Benign Bone Disease
Dynamic 18F-Fluoride Imaging
18F-Fluoride Imaging: Atlas of interesting images (images with specific teaching points, tracer, technique and pitfalls)
Role of Sodium Fluoride-PET in Primary Bone Tumors
18F-Sodium Fluoride Positron Emission Tomography in Cardiac Disease
18F-Sodium Fluoride positron emission tomography / computed tomography imaging of the peripheral vasculature.

Summary: This book explains how the biological systems and their functions are driven by genetic information stored in the DNA, and their expression driven by different factors. The soft computing approach recognizes the different patterns in DNA sequence and try to assign the biological relevance with available information. The book also focuses on using the soft-computing approach to predict protein-protein interactions, gene expression and networks. The insights from these studies can be used in metagenomic data analysis and predicting artificial neural networks.

Contents:
Intro; Preface; Contents; About the Editors;
Chapter 1: Current Scenario on Application of Computational Tools in Biological Systems; 1.1 Introduction; 1.2 Protein Structure Prediction and Interaction; 1.3 Emerging Areas in Tool Development; 1.4 Gene Networks and Plasticity; 1.5 Epigenome: Emerging Area; 1.6 Expanding the Domain of Computational Statistical Analysis; 1.7 Pattern Recognition/Barcoding/Diagnostics; References;
Chapter 2: Diagnostic Prediction Based on Gene Expression Profiles and Artificial Neural Networks; 2.1 Introduction; 2.2 Machine Learning and Artificial Neural Networks. 2.3 Gene Expression Profile2.4 Gene Expression Profile Studies with ANN; 2.4.1 Cancer; 2.4.2 Chemotherapy; 2.4.3 Schizophrenia; 2.5 Perspectives; References;
Chapter 3: Soft Computing Approaches to Extract Biologically Significant Gene Network Modules; 3.1 Introduction; 3.2 Computational Methods for Detecting Network Modules; 3.3 Soft Computing Methods for Network Module Extraction; 3.3.1 Weighted Gene Co-expression Network Analysis (WGCNA); 3.3.2 Fuzzy Network Module Extraction; 3.3.3 GA-RNN Hybrid Approach; 3.3.4 Multisource Integrative Framework; 3.3.5 AutoSOME; 3.4 Assessment. 3.4.1 Dataset3.4.2 Validation; 3.4.2.1 Functional Enrichment Analysis; 3.4.2.2 Topological Validation; 3.4.2.3 Experimental Results; 3.5 Conclusion and Future Scope; References;
Chapter 4: A Hybridization of Artificial Bee Colony with Swarming Approach of Bacterial Foraging Optimization for Multiple Seq ... ; 4.1 Introduction; 4.2 Literature Review; 4.2.1 Genetic Algorithm (GA); 4.2.2 Particle Swarm Optimization (PSO); 4.2.3 Artificial Bee Colony (ABC); 4.2.4 Ant Colony Optimization (ACO); 4.2.5 Bacterial Foraging Optimization (BFO); 4.2.6 Bat and Firefly Optimization; 4.2.7 Cuckoo Search. 4.2.8 Frog Leap Algorithm4.2.9 Multiple Sequence Alignment Using Fuzzy Logic; 4.3 Methodology; 4.3.1 Optimizing the Multi-objectives; 4.3.1.1 Sequence Similarity; 4.3.1.2 Penalty of a Gap; Affine Gap Penalty; Variable Gap Penalty; 4.3.2 Hybrid of ABC-BFO; 4.4 Results; 4.4.1 Applications of MSA; 4.4.2 Statistical Analysis; 4.5 Implementation and Discussion; 4.6 Conclusion; References;
Chapter 5: Construction of Gene Networks Using Expression Profiles; 5.1 Introduction; 5.2 Genetic Regulatory Networks; 5.3 Co-expression Networks; 5.3.1 Identifying Genes with Key Roles. 5.3.2 Construction of Large-Scale Regulatory Networks5.4 Weighted Gene Co-expression Network Analysis (WGCNA); 5.5 Other Gene Co-expression Network Construction Applications; 5.6 Determining the Thresholds and Clusters for Co-expression Networks; 5.7 Network Concepts Useful in Co-expression Network Construction; 5.8 Conclusion; References;
Chapter 6: Bioinformatics Tools for Shotgun Metagenomic Data Analysis; 6.1 Introduction; 6.2 Shotgun Metagenomics; 6.2.1 CAMERA; 6.2.2 MG-RAST; 6.2.3 IMG/M; 6.2.4 METAREP; 6.2.5 CoMet; 6.2.6 METAVIR; 6.2.7 MetaABC; 6.2.8 VIROME; 6.2.9 metaMicrobesOnline.

Summary: "New in the Differential Diagnosis in Surgical Pathology series, this abundantly illustrated title helps you systematically solve tough diagnostic challenges in soft tissue and bone pathology. It uses select images of clinical and pathological findings, together with succinct, expert instructions and diagnostic pearls, to guide you through the decision-making process by distinguishing between commonly confused lesions of soft tissue and bone. By presenting material according to the way pathologists actually work, this user-friendly volume helps you quickly differentiate entities that have overlapping morphologic features"-- Provided by publisher

Summary: In this booklet, experts from across the world, including members of the ISAKOS Knee Arthroplasty Committee, offer clear, up-to-date guidance on all aspects of soft tissue or ligament balancing in primary total knee arthroplasty with the aim of enabling the reader to achieve optimal patient outcomes. After an introduction explaining the normal soft tissue condition in the native knee, surgical procedures are described, including techniques for the management of severe deformity. The most striking feature of the booklet, however, is the many pages devoted to the accurate evaluation and clinical relevance of ligament balancing. Different techniques and devices for intraoperative soft tissue assessment are discussed, highlighting, for example, the use of gap-measuring devices or trial liners with load-bearing sensors to achieve more objective evaluation. Above all, special attention is devoted to the crucial issue of the impact of intraoperative soft tissue balance on postoperative results. In the closing chapter, very experienced surgeons introduce intraoperative troubleshooting in order to assist successful completion of arthroplasty.

Contents:
Native knee: Anatomy and biomechanics
Soft tissue balance in native knee
Knee kinematics in native knee. Operative procedure 1
primary TKA: Primary principals in soft tissue balancing
CR: Measured resection technique
PS: Gap technique
BCR: How to achieve near normal kinematics. Operative procedure 2
primary TKA: Varus knee
severe cases included
Valgus knee
severe cases included
Complicated cases
recurvatum, severe contracture
Increasing ROM. Assessment in primay TKA: Intraoperative assessment
tensor
Intraoperative assessment
navigation
Intraoperative assessment
OrthoSenser. Clinical relevance: primary TKA: Postoperative changes in soft tissue balance
Intraoperative soft tissue balance and postoperative knee kinematics
Intraoperative soft tissue balance and clinical results(ROM, function)
Knee kinematics and patient satisfaction. Patella: Avoiding patellar maltracking
Management of patellar baja and alta. Trouble shooting: Intraoperative MCL injury
Patellar tendon rupture.

Contents:
Critical Concepts in Soft Tissue Pathology
Lipomatous Lesions
Adult Fibroblastic Lesions
Pediatric Fibroblastic Lesions
Fibrohistiocytic Lesions
Pericytic Tumors
Smooth Muscle Tumors
Skeletal Muscle Tumors
Neural and Nerve Sheath Lesions
Vascular Lesions
Chondroid Lesions
Lesions of Uncertain Differentiation
Select Soft Tissue Lesions of the GI Tract.

Summary: This richly illustrated book provides a comprehensive review of the different surgical modalities for hand soft tissue reconstruction. The indications for and relative merits of various techniques are described in detail, emphasizing the role of loco-regional flaps to avoid the need for advanced microsurgical skills needed for other advanced techniques. Numerous illustrations and case descriptions of the common scenarios provide a rich pictorial database of soft tissue coverage options. This illustrative book will be of value in daily practice for plastic and reconstructive surgeons, residents, and medical students.

Contents:
Imaging of tumors and pseudotumours of soft tissues / Valerie Bousson, Jean-Denis Laredo, and Daniel Vanel
Principles of local and systemic treatment of soft tissue sarcomas / Alessandro Gronchi and Paolo G. Casali
Soft tissue sarcomas with spindle cell morphology / Marta Sbaraglia and Angelo Paolo Dei Tos
Soft tissue sarcomas with epithelioid morphology / Marta Sbaraglia and Angelo Paolo Dei Tos
Round cell sarcomas / Alberto Righi, Marco Gambarotti, and Angelo Paolo Dei Tos
Pleomorphic sarcomas / Angelo Paolo Dei Tos
Myxoid sarcomas / Marta Sbaraglia Angelo Paolo Dei Tos
Intermediate malignant and malignant tumors of soft tissue featuring an inflammatory background / Angelo Paolo Dei Tos
Intermediate malignant and malignant tumors of soft tissue resembling normal tissue / Angelo Paolo Dei Tos.

Contents:
Machine generated contents note: ch. 1 Why Wounds Fail to Heal
ch. 2 Initial Evaluation and Management of Complex Traumatic Wounds / Christin A. Harless / Steven L. Moran
ch. 3 Management of Simple Wounds: Local Flaps, Z-Plasty, and Skin Grafts / Emily N. Morgan / George Nanos III
ch. 4 Integra Bilayer Wound Matrix in Combination with Negative Pressure Wound Therapy for Treatment of Extremity Wounds / John B. Hijjawi / Steven L. Moran
ch. 5 Management of Nerve Injuries Following Soft Tissue and Bony Trauma / Kanu Goyal / Ian L. Valerio
ch. 6 Management of Vascular Injuries Following Soft Tissue and Bony Trauma / Ida K. Fox / Amy M. Moore
ch. 7 Restoration of Shoulder External Rotation / Randall R. DeMartino / Gustavo S. Oderich
ch. 8 Rotational Flaps for Rotator Cuff Repair / Kathleen M. Kollitz / Bassem T. Elhassan
ch. 9 Surgical Exposure of the Elbow Following Bony and Soft Tissue Trauma / Kathleen M. Kollitz / Bassem T. Elhassan Note continued: ch. 10 Radial Forearm Flap for Elbow Coverage / Julie E. Adams / Scott P. Steinmann
ch. 11 Anconeus Muscle Flap and Flexor Carpi Ulnaris Muscle Flap for Soft Tissue Coverage of Elbow / Sean R. Cantwell / Brian T. Carlsen
ch. 12 Bipolar Latissimus Dorsi Rotational Flap for Functional Reconstruction of Elbow Flexion / Morad Askari / Bassem T. Elhassan / Steven L. Moran
ch. 13 Fasciotomies for Forearm and I land Compartment Syndrome / Frances Sharpe / Milan Stevanovic
ch. 14 Soft Tissue Management of Delayed Compartment Syndrome / Laura K. Tom / Jeffrey B. Friedrich
ch. 15 Soft Tissue Interposition Flaps in the Management of Heterotopic Ossification and Proximal Radioulnar Synostosis / Milan Stevanovic / Frances Sharpe
ch. 16 Principles of Hand Incisions / M. Claire Manske / Douglas P. Hanel / Seth D. Dodds
ch. 17 Lateral Arm Flap for Hand and Wrist Coverage / Laura W. Lewallen / Marco Rizzo Note continued: ch. 18 Radial Forearm and Radial Forearm Fascial Flap for Coverage of the Dorsum of the Hand and Wrist / Ryan P. Ter Louw / James P. Higgins
ch. 19 Posterior Interosseous Artery Island Flap for Dorsal Hand Coverage / Yoo Joon Sur / Mohamed Morsy / Michel Saint-Cyr
ch. 20 Fillet Flaps in Cases of Mutilating Trauma / Eduardo A. Zancolli
ch. 21 Free Flaps for Upper Extremity Reconstruction and the Anterolateral Thigh Flap / Ryan W. Schmucker / Michael W. Neumeister
ch. 22 Pedicled Flaps from the Groin and Lower Abdomen for Upper Extremity Coverage / Samir Mardini / Harvey Chim / Steven L. Moran / Chih-Hung Lin
ch. 23 Cross-Finger Flaps for Digital Soft Tissue Reconstruction / S. Raja Sabapathy
ch. 24 Heterodigital Arterialized Flap / Nicholas Pulos / Alexander Y. Shin
ch. 25 Homodigital Island Flaps / Shian Chao Tay / Lam Chuan Teoh
ch. 26 First Dorsal Metacarpal Artery Island Flap / Mark Henry Note continued: ch. 27 Flap Reconstruction of the Thumb / Michael Sauerbier / Gunter Germann
ch. 28 Soft Tissue Management Following Traumatic Injury to the Femur / David Elliot / Adam Sierakowski
ch. 29 Management of Soft Tissue Defects Surrounding the Knee and Tibia: The Gastrocnemius Muscle Flap / Thomas F. Higgins / Lance Jacobson
ch. 30 Revision and Infected Total Knee Arthroplasty / Karim Bakri / Steven L. Moran
ch. 31 Pedicled Soleus Muscle Flap for Coverage of the Middle and Distal Third of the Tibia / David J. Jacofsky / Oren Goltzer
ch. 32 Sural Artery Flap / Salvatore C. Lettieri / Steven L. Moran
ch. 33 Propeller Flaps and Keystone Flaps in the Lower Extremity / Michael Sauerbier / Annika Arsalan-Werner
ch. 34 Fasciotomies of the Lower Extremity / Michel Saint-Cyr / Anita T. Mohan
ch. 35 Amputation and Stump Management / Christopher J. Salgado / Harvey Chim / Emily A. Borsting / Jimmy H. Chim / Handel R. Robinson / Yasmina Zoghbi Note continued: ch. 36 Soft Tissue Management of Ankle Fractures and Use of the Gracilis Muscle Flap / Norman S. Turner / Thomas C. Shives
ch. 37 Calcaneal Fractures/Talar Neck Fractures / Steven L. Moran / S. Andrew Sems
ch. 38 Flap Coverage for the Foot / Roy W. Sanders / Hassan R. Mir
ch. 39 Soft Tissue Coverage of the Cervical and Thoracic Spine / L. Scott Levin / William C. Pederson
ch. 40 Soft Tissue Coverage of the Pelvis and Sacrum: Hemipelvectomy and Pedicled Flap Coverage / Christopher J. Salgado / Harvey Chim
ch. 41 Management of Major Upper Limb Amputations / Matt T. Houdek / Peter S. Rose / Franklin H. Sim / Steven L. Moran
ch. 42 Replantation of Digits / S. Raja Sabapathy / Hari Venkatramani.

Summary: The world of soft tissue sarcomas is a highly complex one, due to the large range of tumor types, each of which is characterized by specific features in terms of its epidemiology, pathology diagnosis, clinical behavior, therapy and biomarker pattern (of both diagnostic and therapeutic value). This book offers a practical, clearly structured reference guide, covering all of these aspects for each soft tissue tumor. Thanks to the consistent and user-friendly format, readers can quickly and easily find the information they need; in addition, up-to-date and authoritative literature information helps them to pursue further research. Overall, this book offers professionals and residents in the fields of oncology, surgery, and pathology an essential guide for study, review, and everyday clinical practice.