BookBuwei Yu, Jiaqiang Zhang, Yiming Zeng, Li Li, Xiangdong Wang, editors.
Summary: With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
Contents:
Values of single-cell sequencing and methylation in molecular diagnosis and therapy
Single-cell sequencing in human diseases
Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application
DNA Methylation in pulmonary fibrosis
Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases
Research advances on DNA methylation in idiopathic pulmonary fibrosis
DNA Methylation in Chronic Obstructive Pulmonary Disease
Single cell sequencing: a new dimension in cancer diagnosis
The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers
Clinical Significance of P16 Gene Methylation in Lung Cancer
Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas
Single Cell Sequencing in GU Malignancies
PI3K Isoform-Selective Inhibitors in Cancer
Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases
Single-cell sequencing in human genital infections
PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease
Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells.